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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATXN2L-TCF25 (FusionGDB2 ID:8427)

Fusion Gene Summary for ATXN2L-TCF25

check button Fusion gene summary
Fusion gene informationFusion gene name: ATXN2L-TCF25
Fusion gene ID: 8427
HgeneTgene
Gene symbol

ATXN2L

TCF25

Gene ID

11273

22980

Gene nameataxin 2 liketranscription factor 25
SynonymsA2D|A2LG|A2LP|A2RPFKSG26|Hulp1|NULP1|PRO2620|hKIAA1049
Cytomap

16p11.2

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionataxin-2-like proteinataxin 2 related proteinataxin-2 domain proteintranscription factor 25TCF-25nuclear localized protein 1transcription factor 25 (basic helix-loop-helix)
Modification date2020032020200313
UniProtAcc

Q8WWM7

.
Ensembl transtripts involved in fusion geneENST00000325215, ENST00000336783, 
ENST00000340394, ENST00000382686, 
ENST00000395547, ENST00000564304, 
ENST00000570200, ENST00000565845, 
ENST00000263347, ENST00000563406, 
ENST00000263346, 
Fusion gene scores* DoF score4 X 5 X 3=6015 X 14 X 9=1890
# samples 519
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1890*10)=-3.31431491077749
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATXN2L [Title/Abstract] AND TCF25 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATXN2L(28834879)-TCF25(89976998), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATXN2L

GO:0010603

regulation of cytoplasmic mRNA processing body assembly

23209657

TgeneTCF25

GO:0000122

negative regulation of transcription by RNA polymerase II

16574069


check buttonFusion gene breakpoints across ATXN2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TCF25 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A7HVATXN2Lchr16

28834879

+TCF25chr16

89976998

+


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Fusion Gene ORF analysis for ATXN2L-TCF25

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000325215ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000325215ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000336783ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000336783ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000340394ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000340394ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000382686ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000382686ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000395547ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000395547ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000564304ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000564304ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000570200ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
5CDS-intronENST00000570200ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
In-frameENST00000325215ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
In-frameENST00000336783ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
In-frameENST00000340394ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
In-frameENST00000382686ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
In-frameENST00000395547ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
In-frameENST00000564304ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
In-frameENST00000570200ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
intron-3CDSENST00000565845ENST00000263346ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
intron-intronENST00000565845ENST00000263347ATXN2Lchr16

28834879

+TCF25chr16

89976998

+
intron-intronENST00000565845ENST00000563406ATXN2Lchr16

28834879

+TCF25chr16

89976998

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340394ATXN2Lchr1628834879+ENST00000263346TCF25chr1689976998+889511212742176
ENST00000325215ATXN2Lchr1628834879+ENST00000263346TCF25chr1689976998+844466167697176
ENST00000382686ATXN2Lchr1628834879+ENST00000263346TCF25chr1689976998+844466167697176
ENST00000395547ATXN2Lchr1628834879+ENST00000263346TCF25chr1689976998+844466167697176
ENST00000336783ATXN2Lchr1628834879+ENST00000263346TCF25chr1689976998+844466167697176
ENST00000564304ATXN2Lchr1628834879+ENST00000263346TCF25chr1689976998+842464165695176
ENST00000570200ATXN2Lchr1628834879+ENST00000263346TCF25chr1689976998+6853078538176

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340394ENST00000263346ATXN2Lchr1628834879+TCF25chr1689976998+0.0080839550.991916
ENST00000325215ENST00000263346ATXN2Lchr1628834879+TCF25chr1689976998+0.0072988560.9927012
ENST00000382686ENST00000263346ATXN2Lchr1628834879+TCF25chr1689976998+0.0072988560.9927012
ENST00000395547ENST00000263346ATXN2Lchr1628834879+TCF25chr1689976998+0.0072988560.9927012
ENST00000336783ENST00000263346ATXN2Lchr1628834879+TCF25chr1689976998+0.0072988560.9927012
ENST00000564304ENST00000263346ATXN2Lchr1628834879+TCF25chr1689976998+0.0073532440.9926468
ENST00000570200ENST00000263346ATXN2Lchr1628834879+TCF25chr1689976998+0.0034346450.9965654

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Fusion Genomic Features for ATXN2L-TCF25


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATXN2Lchr1628834879+TCF25chr1689976998+0.071313690.9286863
ATXN2Lchr1628834879+TCF25chr1689976998+0.071313690.9286863

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATXN2L-TCF25


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:28834879/chr16:89976998)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATXN2L

Q8WWM7

.
FUNCTION: Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000325215+1234_84991063.0Compositional biasNote=Pro-rich
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000336783+1224_84991076.0Compositional biasNote=Pro-rich
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000340394+1234_84991045.0Compositional biasNote=Pro-rich
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000382686+1234_84991045.0Compositional biasNote=Pro-rich
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000395547+1244_84991112.6666666666667Compositional biasNote=Pro-rich
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000570200+1234_84991063.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATXN2L-TCF25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8427_8427_1_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000325215_TCF25_chr16_89976998_ENST00000263346_length(transcript)=844nt_BP=466nt
CCGCGGTCTTCTCTCTCCACCCCCGACACCGCGGGGCTCCCCCCGCCCGCCCACGGCGGGCCCCGGCTGCCCGATCCCCCTCGCTTCCCG
CGCTCTCCAGCGGGGCCCCAGCCCCGGCCCCCTCTCTCCCTCCCTTCTCTCTAATTCCCCTTCCGGACGCTGCCATCATGTTGAAGCCTC
AGCCGCTACAACAGCCCTCCCAGCCCCAGCAGCCGCCCCCCACGCAACAGGCCGTGGCCCGTCGGCCCCCCGGGGGCACCAGCCCTCCCA
ACGGCGGCCTCCCGGGGCCGCTGGCCACCTCTGCGGCTCCTCCCGGGCCTCCAGCGGCCGCCTCCCCCTGCCTGGGGCCTGTGGCCGCTG
CCGGGAGCGGGCTCCGCCGGGGAGCCGAAGGCATCTTGGCGCCGCAGCCGCCGCCGCCGCAGCAACACCAGGAGAGGCCGGGGGCAGCCG
CCATCGGCAGCGCCAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATGGAGG
GGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATGGCCA
ACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACCGAAA
AGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTGAGTGTGTCGCTCCCTGGTCCA

>8427_8427_1_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000325215_TCF25_chr16_89976998_ENST00000263346_length(amino acids)=176AA_BP=3
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQER

--------------------------------------------------------------
>8427_8427_2_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000336783_TCF25_chr16_89976998_ENST00000263346_length(transcript)=844nt_BP=466nt
CCGCGGTCTTCTCTCTCCACCCCCGACACCGCGGGGCTCCCCCCGCCCGCCCACGGCGGGCCCCGGCTGCCCGATCCCCCTCGCTTCCCG
CGCTCTCCAGCGGGGCCCCAGCCCCGGCCCCCTCTCTCCCTCCCTTCTCTCTAATTCCCCTTCCGGACGCTGCCATCATGTTGAAGCCTC
AGCCGCTACAACAGCCCTCCCAGCCCCAGCAGCCGCCCCCCACGCAACAGGCCGTGGCCCGTCGGCCCCCCGGGGGCACCAGCCCTCCCA
ACGGCGGCCTCCCGGGGCCGCTGGCCACCTCTGCGGCTCCTCCCGGGCCTCCAGCGGCCGCCTCCCCCTGCCTGGGGCCTGTGGCCGCTG
CCGGGAGCGGGCTCCGCCGGGGAGCCGAAGGCATCTTGGCGCCGCAGCCGCCGCCGCCGCAGCAACACCAGGAGAGGCCGGGGGCAGCCG
CCATCGGCAGCGCCAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATGGAGG
GGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATGGCCA
ACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACCGAAA
AGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTGAGTGTGTCGCTCCCTGGTCCA

>8427_8427_2_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000336783_TCF25_chr16_89976998_ENST00000263346_length(amino acids)=176AA_BP=3
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQER

--------------------------------------------------------------
>8427_8427_3_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000340394_TCF25_chr16_89976998_ENST00000263346_length(transcript)=889nt_BP=511nt
AGCCGCGAGACCCCCTCCCCTTCCGCCTCGCGGCGCTTCCTCGCGCCGCGGTCTTCTCTCTCCACCCCCGACACCGCGGGGCTCCCCCCG
CCCGCCCACGGCGGGCCCCGGCTGCCCGATCCCCCTCGCTTCCCGCGCTCTCCAGCGGGGCCCCAGCCCCGGCCCCCTCTCTCCCTCCCT
TCTCTCTAATTCCCCTTCCGGACGCTGCCATCATGTTGAAGCCTCAGCCGCTACAACAGCCCTCCCAGCCCCAGCAGCCGCCCCCCACGC
AACAGGCCGTGGCCCGTCGGCCCCCCGGGGGCACCAGCCCTCCCAACGGCGGCCTCCCGGGGCCGCTGGCCACCTCTGCGGCTCCTCCCG
GGCCTCCAGCGGCCGCCTCCCCCTGCCTGGGGCCTGTGGCCGCTGCCGGGAGCGGGCTCCGCCGGGGAGCCGAAGGCATCTTGGCGCCGC
AGCCGCCGCCGCCGCAGCAACACCAGGAGAGGCCGGGGGCAGCCGCCATCGGCAGCGCCAGGCTAAGTCCTATCAGCCATGGAAACACCA
TTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATGGAGGGGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACC
AGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATGGCCAACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTG
AGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACCGAAAAGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGC

>8427_8427_3_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000340394_TCF25_chr16_89976998_ENST00000263346_length(amino acids)=176AA_BP=3
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQER

--------------------------------------------------------------
>8427_8427_4_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000382686_TCF25_chr16_89976998_ENST00000263346_length(transcript)=844nt_BP=466nt
CCGCGGTCTTCTCTCTCCACCCCCGACACCGCGGGGCTCCCCCCGCCCGCCCACGGCGGGCCCCGGCTGCCCGATCCCCCTCGCTTCCCG
CGCTCTCCAGCGGGGCCCCAGCCCCGGCCCCCTCTCTCCCTCCCTTCTCTCTAATTCCCCTTCCGGACGCTGCCATCATGTTGAAGCCTC
AGCCGCTACAACAGCCCTCCCAGCCCCAGCAGCCGCCCCCCACGCAACAGGCCGTGGCCCGTCGGCCCCCCGGGGGCACCAGCCCTCCCA
ACGGCGGCCTCCCGGGGCCGCTGGCCACCTCTGCGGCTCCTCCCGGGCCTCCAGCGGCCGCCTCCCCCTGCCTGGGGCCTGTGGCCGCTG
CCGGGAGCGGGCTCCGCCGGGGAGCCGAAGGCATCTTGGCGCCGCAGCCGCCGCCGCCGCAGCAACACCAGGAGAGGCCGGGGGCAGCCG
CCATCGGCAGCGCCAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATGGAGG
GGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATGGCCA
ACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACCGAAA
AGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTGAGTGTGTCGCTCCCTGGTCCA

>8427_8427_4_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000382686_TCF25_chr16_89976998_ENST00000263346_length(amino acids)=176AA_BP=3
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQER

--------------------------------------------------------------
>8427_8427_5_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000395547_TCF25_chr16_89976998_ENST00000263346_length(transcript)=844nt_BP=466nt
CCGCGGTCTTCTCTCTCCACCCCCGACACCGCGGGGCTCCCCCCGCCCGCCCACGGCGGGCCCCGGCTGCCCGATCCCCCTCGCTTCCCG
CGCTCTCCAGCGGGGCCCCAGCCCCGGCCCCCTCTCTCCCTCCCTTCTCTCTAATTCCCCTTCCGGACGCTGCCATCATGTTGAAGCCTC
AGCCGCTACAACAGCCCTCCCAGCCCCAGCAGCCGCCCCCCACGCAACAGGCCGTGGCCCGTCGGCCCCCCGGGGGCACCAGCCCTCCCA
ACGGCGGCCTCCCGGGGCCGCTGGCCACCTCTGCGGCTCCTCCCGGGCCTCCAGCGGCCGCCTCCCCCTGCCTGGGGCCTGTGGCCGCTG
CCGGGAGCGGGCTCCGCCGGGGAGCCGAAGGCATCTTGGCGCCGCAGCCGCCGCCGCCGCAGCAACACCAGGAGAGGCCGGGGGCAGCCG
CCATCGGCAGCGCCAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATGGAGG
GGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATGGCCA
ACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACCGAAA
AGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTGAGTGTGTCGCTCCCTGGTCCA

>8427_8427_5_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000395547_TCF25_chr16_89976998_ENST00000263346_length(amino acids)=176AA_BP=3
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQER

--------------------------------------------------------------
>8427_8427_6_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000564304_TCF25_chr16_89976998_ENST00000263346_length(transcript)=842nt_BP=464nt
GCGGTCTTCTCTCTCCACCCCCGACACCGCGGGGCTCCCCCCGCCCGCCCACGGCGGGCCCCGGCTGCCCGATCCCCCTCGCTTCCCGCG
CTCTCCAGCGGGGCCCCAGCCCCGGCCCCCTCTCTCCCTCCCTTCTCTCTAATTCCCCTTCCGGACGCTGCCATCATGTTGAAGCCTCAG
CCGCTACAACAGCCCTCCCAGCCCCAGCAGCCGCCCCCCACGCAACAGGCCGTGGCCCGTCGGCCCCCCGGGGGCACCAGCCCTCCCAAC
GGCGGCCTCCCGGGGCCGCTGGCCACCTCTGCGGCTCCTCCCGGGCCTCCAGCGGCCGCCTCCCCCTGCCTGGGGCCTGTGGCCGCTGCC
GGGAGCGGGCTCCGCCGGGGAGCCGAAGGCATCTTGGCGCCGCAGCCGCCGCCGCCGCAGCAACACCAGGAGAGGCCGGGGGCAGCCGCC
ATCGGCAGCGCCAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGTTGCCAAACTATACCATGGAGGGG
GAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGGCTGTGCGCGACATGATGGCCAAC
TTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAGCGTCCGCAGAGGTGACCGAAAAG
CCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTGAGTGTGTCGCTCCCTGGTCCACT

>8427_8427_6_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000564304_TCF25_chr16_89976998_ENST00000263346_length(amino acids)=176AA_BP=3
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQER

--------------------------------------------------------------
>8427_8427_7_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000570200_TCF25_chr16_89976998_ENST00000263346_length(transcript)=685nt_BP=307nt
CTGCCATCATGTTGAAGCCTCAGCCGCTACAACAGCCCTCCCAGCCCCAGCAGCCGCCCCCCACGCAACAGGCCGTGGCCCGTCGGCCCC
CCGGGGGCACCAGCCCTCCCAACGGCGGCCTCCCGGGGCCGCTGGCCACCTCTGCGGCTCCTCCCGGGCCTCCAGCGGCCGCCTCCCCCT
GCCTGGGGCCTGTGGCCGCTGCCGGGAGCGGGCTCCGCCGGGGAGCCGAAGGCATCTTGGCGCCGCAGCCGCCGCCGCCGCAGCAACACC
AGGAGAGGCCGGGGGCAGCCGCCATCGGCAGCGCCAGGCTAAGTCCTATCAGCCATGGAAACACCATTGCTCTCTTCTTCCGGTCACTGT
TGCCAAACTATACCATGGAGGGGGAGAGGCCCGAGGAAGGAGTGGCTGGGGGTCTGAACCGCAACCAGGGCCTGAACAGGCTGATGCTGG
CTGTGCGCGACATGATGGCCAACTTCCACCTCAACGACCTGGAGGCGCCGCACGAGGACGACGCTGAGGGGGAGGGGGAGTGGGACTGAG
CGTCCGCAGAGGTGACCGAAAAGCCGTATGATGATGTTCCCGATTTCTCTGTTGGTCGGAGTCGGCCAGTTGCCTGAAGTAGGGAAGCTG

>8427_8427_7_ATXN2L-TCF25_ATXN2L_chr16_28834879_ENST00000570200_TCF25_chr16_89976998_ENST00000263346_length(amino acids)=176AA_BP=3
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQER

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Fusion Gene PPI Analysis for ATXN2L-TCF25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000325215+12398_12199.666666666666671063.0MPL
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000336783+12298_12199.666666666666671076.0MPL
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000340394+12398_12199.666666666666671045.0MPL
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000382686+12398_12199.666666666666671045.0MPL
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000395547+12498_12199.666666666666671112.6666666666667MPL
HgeneATXN2Lchr16:28834879chr16:89976998ENST00000570200+12398_12199.666666666666671063.0MPL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATXN2L-TCF25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATXN2L-TCF25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource