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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SMS-DYRK2 (FusionGDB2 ID:84280)

Fusion Gene Summary for SMS-DYRK2

Fusion gene summary

Fusion gene information	Fusion gene name: SMS-DYRK2
	Fusion gene ID: 84280
		Hgene	Tgene
	Gene symbol	SMS	DYRK2
	Gene ID	10743	8445
	Gene name	retinoic acid induced 1	dual specificity tyrosine phosphorylation regulated kinase 2
	Synonyms	SMCR\|SMS	-
	Cytomap	17p11.2	12q15
	Type of gene	protein-coding	protein-coding
	Description	retinoic acid-induced protein 1Smith-Magenis syndrome chromosome region	dual specificity tyrosine-phosphorylation-regulated kinase 2dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q92630
	Ensembl transtripts involved in fusion gene	ENST00000478094, ENST00000379404, ENST00000404933, ENST00000415881,	ENST00000344096, ENST00000537632, ENST00000393555,
Fusion gene scores	* DoF score	4 X 1 X 4=16	8 X 5 X 7=280
	# samples	4	8
	** MAII score	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SMS [Title/Abstract] AND DYRK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMS(21958991)-DYRK2(68043577), # samples:2
Anticipated loss of major functional domain due to fusion event.	SMS-DYRK2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. SMS-DYRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SMS-DYRK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SMS-DYRK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SMS-DYRK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SMS	GO:0045893	positive regulation of transcription, DNA-templated	22578325
Tgene	DYRK2	GO:0006468	protein phosphorylation	11311121
Tgene	DYRK2	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17349958
Tgene	DYRK2	GO:0045725	positive regulation of glycogen biosynthetic process	11311121

Fusion gene breakpoints across SMS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DYRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A14T-01A	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
ChimerDB4	BRCA	TCGA-E2-A14T-01A	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+

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Fusion Gene ORF analysis for SMS-DYRK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000478094	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
3UTR-3CDS	ENST00000478094	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
3UTR-3UTR	ENST00000478094	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
3UTR-5UTR	ENST00000478094	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
3UTR-intron	ENST00000478094	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
3UTR-intron	ENST00000478094	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
5CDS-3UTR	ENST00000379404	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
5CDS-3UTR	ENST00000404933	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
5CDS-5UTR	ENST00000379404	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
5CDS-5UTR	ENST00000404933	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
5CDS-intron	ENST00000379404	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
5CDS-intron	ENST00000379404	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
5CDS-intron	ENST00000404933	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
5CDS-intron	ENST00000404933	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
5UTR-3CDS	ENST00000415881	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
5UTR-3CDS	ENST00000415881	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
5UTR-3UTR	ENST00000415881	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
5UTR-5UTR	ENST00000415881	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
5UTR-intron	ENST00000415881	ENST00000393555	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
5UTR-intron	ENST00000415881	ENST00000537632	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
Frame-shift	ENST00000379404	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
Frame-shift	ENST00000404933	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68050886	+
In-frame	ENST00000379404	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+
In-frame	ENST00000404933	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000404933

SMS

chrX

21958991

ENST00000344096

DYRK2

chr12

68043577

8751

301

252

2057

601

ENST00000379404

SMS

chrX

21958991

ENST00000344096

DYRK2

chr12

68043577

8609

159

110

1915

601

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000404933	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+	0.000686637	0.99931335
ENST00000379404	ENST00000344096	SMS	chrX	21958991	+	DYRK2	chr12	68043577	+	0.000671921	0.99932814

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Fusion Genomic Features for SMS-DYRK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SMS	chrX	21958991	+	DYRK2	chr12	68043576	+	0.003124736	0.9968753
SMS	chrX	21958991	+	DYRK2	chr12	68050885	+	2.58E-07	0.99999976
SMS	chrX	21958991	+	DYRK2	chr12	68043576	+	0.003124736	0.9968753
SMS	chrX	21958991	+	DYRK2	chr12	68050885	+	2.58E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMS-DYRK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:21958991/chr12:68043577)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DYRK2 Q92630
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269\|PubMed:11311121, ECO:0000269\|PubMed:12588975, ECO:0000269\|PubMed:14593110, ECO:0000269\|PubMed:15910284, ECO:0000269\|PubMed:16511445, ECO:0000269\|PubMed:16611631, ECO:0000269\|PubMed:17349958, ECO:0000269\|PubMed:18455992, ECO:0000269\|PubMed:18599021, ECO:0000269\|PubMed:19287380, ECO:0000269\|PubMed:22307329, ECO:0000269\|PubMed:22878263, ECO:0000269\|PubMed:23362280, ECO:0000269\|PubMed:9748265}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DYRK2

chrX:21958991

chr12:68043577

ENST00000344096

222_535

602.0

Domain

Protein kinase

Tgene

DYRK2

chrX:21958991

chr12:68043577

ENST00000393555

222_535

529.0

Domain

Protein kinase

Tgene

DYRK2

chrX:21958991

chr12:68043577

ENST00000344096

228_236

602.0

Nucleotide binding

ATP

Tgene

DYRK2

chrX:21958991

chr12:68043577

ENST00000344096

301_304

602.0

Nucleotide binding

ATP

Tgene

DYRK2

chrX:21958991

chr12:68043577

ENST00000393555

228_236

529.0

Nucleotide binding

ATP

Tgene

DYRK2

chrX:21958991

chr12:68043577

ENST00000393555

301_304

529.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMS

chrX:21958991

chr12:68043577

ENST00000379404

122_362

314.0

Domain

PABS

Hgene

SMS

chrX:21958991

chr12:68043577

ENST00000404933

122_362

367.0

Domain

PABS

Hgene

SMS

chrX:21958991

chr12:68043577

ENST00000379404

255_256

314.0

Region

Note=S-adenosylmethioninamine binding

Hgene

SMS

chrX:21958991

chr12:68043577

ENST00000404933

255_256

367.0

Region

Note=S-adenosylmethioninamine binding

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Fusion Gene Sequence for SMS-DYRK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>84280_84280_1_SMS-DYRK2_SMS_chrX_21958991_ENST00000379404_DYRK2_chr12_68043577_ENST00000344096_length(transcript)=8609nt_BP=159nt
GGCCTCCCCGGGCGCAGCACACTCCCAGCCGGCCGCAGCCTGACACGCCGCGCGGCCCCCCAGTCTCCCGCGGCTGCTCCCCCAGGCATG
GCACAGGGCCTCGCCTCACTATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGGCCGAGGTGGGGACAGCGCCG
TTCGTCAGCTTCAGGCTTCCCCGGGGCTCGGTGCAGGGGCCACCCGGAGCGGAGTGGGGACTGGCCCGCCCTCCCCCATCGCCCTGCCGC
CTCTCCGGGCCAGCAACGCTGCCGCCGCAGCCCACACGATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTCGGCAGCCACG
CTCACGGACAGATCCAGGTTCAACAGTTGTTTGAGGATAACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAG
TGGGCAAAACGGGCTTGCCAGTGGTGCCAGAGCGGCAGCTGGACAGCATTCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGG
AAGGCATGGGGAAGGTGAAAGCCACCCCCATGACACCTGAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCATG
AGATTTTCAGCTACCCTGAAATATATTTCTTGGGTCTAAATGCTAAGAAGCGCCAGGGCATGACAGGTGGGCCCAACAATGGTGGCTATG
ATGATGACCAGGGATCATATGTGCAGGTGCCCCACGATCACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTTG
GGCAGGTGGTCAAGGCCTACGATCACAAAGTCCACCAGCACGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCAG
CGGAGGAGATCCGAATCCTGGAACACCTGCGGAAGCAGGACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCC
GCAACCACATCTGCATGACGTTTGAGCTGCTGAGCATGAACCTCTATGAGCTCATCAAGAAGAATAAATTCCAGGGCTTCAGTCTGCCTT
TGGTTCGCAAGTTTGCCCACTCGATTCTGCAGTGCTTGGATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAACA
TTTTGTTAAAGCAGCAGGGTAGAAGCGGTATTAAAGTAATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTACACGTACATCC
AGTCGCGTTTTTACCGGGCTCCAGAAGTGATCCTTGGGGCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAG
AGCTCCTGACGGGTTACCCCCTCTTGCCTGGGGAAGATGAAGGGGACCAGCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGA
AACTGCTGGATGCATCCAAACGAGCCAAAAATTTTGTGAGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGCT
CTGTGGTCCTAAACGGAGGCCGTTCCCGGAGGGGGAAACTGAGGGGCCCACCGGAGAGCAGAGAGTGGGGGAACGCGCTGAAGGGGTGTG
ATGATCCCCTTTTCCTTGACTTCTTAAAACAGTGTTTAGAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCCT
GGCTGAGGAGGCGGTTGCCAAAGCCTCCCACCGGGGAGAAAACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATAT
CCAAGTTACCTCCACCTTCTAGCTCAGCTTCCAAACTGAGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGA
CAGTGTTGCCAAAACTTGTTAGCTGAGCTCACGTCCCCTGATGCTGGTAACCTGAAAGATACGACATTGCTGAGCCTTACTGGGTTGAAA
AGGAGTAGCTCAGACCTGTTTTTATTTGCTCAATAACTCTACTCATTTGTATCTTTTCAGCACTTAATTTTAATGTAAGAAAGTTGTTCA
TTTTGTTTTTATAAAATACATGAGGACAATGCTTTAAGTTTTTATACTTTCAGAAACTTTTTGTGTTCTAAAAGTACAATGAGCCTTACT
GTATTTAGTGTGGCAGAATAATAACATCAGTGGCAGGCCACTGATTACTTCATGACTGCCACGCATTTACAGATTGGTGTCAAAGACATT
CACTATGTTTTTATGGTTCATGTTATATCCTCCCCAGGGTGACAGCCCCTTAAGGCCCTCCTTTTCCCTCCATGCTCCAGGTCCATGCAC
AGGTGTAGCATGTCCTGCTTCCGTTTTTCATAAATTAATCTGGGTGTTGGGGGTAGTGGGAGGAGAACGGTCAGAATCAAAGTGACATTC
TAAGAAAAACTGTACCTTAGAGATTTTCCTCTAGTGCTCAAACAAATACAAAATAAGATCCCCAAGGTTTAAACTGCCCAGTTAGCATTC
TGACATTCTAAAAGCCGGCAAAGCAGCTTTTAGTGGATAAATGGGAATGGAAACGTGTGTGTTCCTCCAAATTTTCTAGTATGATCGGTG
AGCTGTTTTGTAAAGAAGCCTCATATTACAGAGTTGCTTTTGCACCTAAATTTAGAATTGTATTCCATGAACTGTTCCTCCCTTTTCTCT
GCTTTTCTCCTCTCTGTTCCTCTTTTAATACCACACGTCTGTTGCTTGCATTTAGTTTGTCTTCTTCCTTCAGCTGTGTATCCCAGACTG
TTAATACAGAAAAGAGACATTTCAGCTGTGATTATGACCATTGTTTCATATTCCAATTAAAAAAAGAACAGCAGCCTAGCTACTTAAGGT
GGGGATTTCCATAGTTCCAAAGAAGATTTAGCAGATTAGAGTGAGTTCACACTTTTCAGGTGCCACTGTAAGGTTCTCTCAGCCTGGGAA
ACTATCAACTCTTTCTTTAAAAAGAAAGAGGGTTGAAAATCCTCTGGACGAACAGAAGTCACTTTGGCTGTTCAGTAAGGCCAATGTTAA
CAACACGTTTAGAGGAGGAAAAGTTCAACCTCAAGTTAAATGGTTTGACTTATTCTTCGTATCATTAGAAGAACCCCAGAGATAGCATTC
CTCTATTTTATTTTACTTTCTTTTGGATTGCACTGATTGTTTTTGTGGGAATGACACTTTATCTGGCAAAGTAACTGAGAGTTTGGTAAA
AGAATATTTTCTTCTCTGAATAATAATTATTTTCACAGTGAAAATTTCAGTATTTTATCACTAATGTATGAGCAATGATCTATATCAATT
TCAAGGCACGTGAAAAAAATTTTTTAGTATGTGCAATTTAATATAGAAAGATTTCTGCCTGTTTGGACAATAGGTTTTGGGTAGTACAGA
TTAGGATAAGTAAGCTTATATATGCACAGAGATTATTGTATTACCTGTAAATTGATTTACAAGTACTTAAAAGCGTGGTCCCCAGTGAGG
CCAAGAAAGTTTCCGGTTAAGTTCTTTAATAATAATCCTACAGTTTATCTTAAGAAAAAAAAAAAGGTTTGAAAAAAACACTTTAATTTA
GGCTTCGTTGGTTGATGGTGGAAAAAAATGCTCAGGAAATATTTCAGATATTTGCCAAAAAACCAGTAATAAGGTTACCTTATTAAAATA
GTGATATTTGCTTTACTATTTAAGGTGTCACTGATAAATTAATTTGTACTTCTGTGTTTAGAAATTATAGCTTCTTTTCCCTTAGTCAAA
TTTTTTAGCATATTATACACATTTCTGTGTAATCTGTGGAAGTGCAATAATATGTTAGTAAGTTACATTTTAAATAATGCTCATGTGACA
ATACTCCCAATCAATGGCTTATAGAATTTAAAGATCTGTATATTAGATTTTGGCTTAAAGGCATGAGAAGTATAAGACTTGGTTTGGTGG
CTTTGTAAGACCACCAGCCTCTTAATGATGGTTAGCTTCTTTAGGTCATTAAATCAATAAAAACATATAATGCTGTTTTGCTCTTCTAAT
GCTCCTCTTCCATTTCCAGTTATCTTCACATTTACATTTAAATATACAAACCTGAGCCTGCCATTATTAATTTCCCTATAAAATGACGAT
ACATGTGAACATTTATAAATGGACTAATACTGCTTGTCTTTCCCCCACCGCACAAAACTGGTTCTTAAGATGCCAGCAATGAATTTGAGA
CTATCTTTATTTATAAATGGAAACCGGAAACTTTTATACCAAACTATAATAATGTGCAGCACTGTAGGGCTTTTTTTTTTTTCCCTCCAA
ATACAGTGAAATTTTTTTATTCACAAGAGCTGCCACATCTCAGCATTTAGTAATAGAGCTGCTTTAATAAAATTCTAGTTTGATTGTCAT
GTCAAAAAAAGAAAAATGTTGCATCTTTGTGATTTTAAAACATAAATTAATGAAGGCTCTGATAGGCTATTAGGAGTTGGCTTGGAAACA
GTTTTTGGTCTCACAGGTTACCATTGTTTGGGGATGTCTGAGCTGTTTTCAGATCTAGGAATAGCACAGTGTTGTCTTGTCTTTGGCAGT
CTCATTTGGCTCTGTTTCTTGCACCACCAGCGTGTTCATTACCACTTAAATATATTGCTACAGCAGTGGAACAACAGAGTGGTGCAAGAC
ACTGTAGATTAACGGTAGAGGAGAAATTGTGCCCTTAGTGTTAACAATGTGCCTTTTGTTCTGAATGCCATGTTGTAGGGCATGCATTTT
TTGGCCTCTTTAACTCTTCGAATTCTAGTCAGTAAGAATGGAACCCATCTCTGCAAAGATACATCTGTCTTAAATATCTAGTTACAGGCC
TTAATAGAAACCATAAGGCATGACTCATCTTCAGGCACTGAAAAAAGATAACCATCAGGTAGTGTTACACAAGGACTTCCTATATTTAAG
GGGTTAAAGATGGTCTTTGTTGTATCTTAACATCAGACTGATTTTTACATTTTTTTTTTGTTATGCTAACACTAGACAAAAATCAACTGT
ATTTGTAAAAATTTACCTCAAACCATTTAATTTTATAGTGTGATTAATCCCAGGGCATTTGGTATGAACCAAAGTGCATTCCTTTTATAT
GTGCCTGGCTCTAGTAAGGATGGCCAGGGATTTTTACAATTTGGGTGCAAGGCACTTAAGCCACTTTTAAACTTAATGGGTGGTTTGGGG
TCGTGTTAAATGACTCCATCAGAATGTTAGAAAACACTTTAGGCATCAGTAGCATTGGGCCATATTGGAATCCTAAAGTGTGAATTATTT
TAAGGAGAGCATTCATTTTTGTAATTTTTTTCATCAAAAATATTTCTGGTAAGCAGAAGACTTTTTAAAAAAACTGATCTGGTCTCGGTA
AAGGTTTTAATATTGCCCAACATAATGCTGTAATAGCATTAAAAAAAGTATTTGTGAACTCTGTTTCTTAGGGGCTTGTACATCTCTCTG
CTATGGACATACATAAAATTAATTGTAATTATACTCAGCTCAACTGCTACAGTTCTGTCTAGGCAGTGGCTTGGGTTTTTATCGAGCAAC
AACTTAGACACGTGACTGTAATATGCTGCAACTGTGTGTACTGAAAATATGTGAAAATGGTTGAATGTGGACTGTGTATATATGTATGTA
AAAATTTCTGTGAGATGCTGCTGTCGCCACTTAACATTAAATATGTTCTAGTGGATTTTAATCCTAGTGGCCAGTTCTATGATACTGTAT
GTATTATACAGCTGATGACAGGAGTAAGACTGTTTAGTGAATATCTGTTAAATTTTATTGTTGTGGCCAGAGATAATTTCAGAATAAAAT
TTTAATGTCCTACCTTACTTCTCTCCCCTTTCTAACTATAATTTAACTCCTGATCTATTTCTGGTATTATCCTTTGTCAATTAGCCTGGA
GAGGGTTTAGAATGCAAAATGGATAGCTCTATATCAGGGTCTTGAGAAGTTAAAATAATTCATTCTACTAGTTTGTTCATAGCAATACTT
TATTAGTTCAATATAAGTATGCAGATTCCAAGTGGAAAAACAAAGGTTTTAGTAAGTAGTTCTTGCTTTTCCCAGGATATTCTATTCCTT
CACCTGTCAGATTTTTATGTTAACTTTTTTATATATAGCCTCTGCTGTGTTCTTTATTATGCTAGAGCTTCATATCTTCTTTTATTTTAA
CCTTCACAATGATAGTTAAGCTGGGGGAGCAGAACCTGTCAATTATTCCCCACCAGTCTTCATTCTTTTCTCTGCACAAGTTCTGGTAAA
TTATTCTAATGTGCTCTAACCAGTTCCACCCAATGTTTTTTAATGCTTATGAGTTTGCAGTTTTTGTACTTGGTGGTCTCTGTGGTTCAC
ATTTTTTTGTGTTGTAGTGTCTCCTGCCTCGGTTGGCTCAGAAAATAAGGCCTAGGAACTGCAATTAGCTCATGATTTGTCAAGTTCAGT
TAGTACCAAGCTAAGAGTTTACTTACAGATGACAGCAAGCAGATGCTCTAGTAATTCGTCAGACATTGCAGGGATATTGTGTAGTCAGAT
ATTACCCTCTTGTGGAAAGAACTACCTCACATCATTATTTATTTCCCTTCTGTTACCAACAGCCAAGGAATTACTTAGTGTGGCTCCCTG
CATCAATACTGGGATATGCTTAAACAAGGGAATGCCATAAGAGTTCCCAATTGCCTCGTCATAGCCTGGGCCATAGATTTTTGTTACTGC
TAATCTTGCTTCTTAAAGTTCACACCCAGTGCAAAAAACCCAATCAGCAAACTAACCCCAAAATCCAATATATTTAGAAATGTAAGTGTT
AAGAGATGTGCATTATGTACAAAATTGAAAATTGGTGCTAAAGTGGCAATGTCAATTTAAAATTTCTTGTCCAGATCTGACTGACTGACT
CAGGAGATTATAGTTCCTACTCATTCTCTTTCCTTTTATCAGATCTTTCAAAAGCGCTTTTTAAAATTGATCAATGTGCAATTCTGTTTG
AGTCTCTACAGTCCTATCCCTTTTGGAATGAACAGCTACACAAATAAATATTCTTGGAACTTCGAAGTTGTCTTCAAACTAGCTCTAGAA
AATGTCCCTAGTTGACATTAGTGTTGGTCTGTTAGAAGGGGAAATTGATTTGACTGCTTCATGTTTTGAAAAGAGCATTAAGAGGGATTT
GAGGAAGGTATATGTGGCTTTCTTTTTTTTTCTTAAGTTTGAATTACACTTGATTTCCTTTGGGTTATTAGGCAGATAAACCCTTGTCAT
TAGTAATACTTAGCACTGTCCAAAATGAAAAATGACTGCCAGTGTGTTGCACATACATAAGAAAATTACATCTTACTGCGAAGTCTTTGG
TTTGTTTCCTTATTTGGTTTGACTTTGACTTACTATTTTGCTATGGTCATATCCTTAATATCTGCGGTACATTTCATATATATATATGGG
GTGGGAGCATAATTGCCATTCCCATGTGTCTCAAGGAAGCTTAATGAGGAAACTAATGAGTTAATATTAACTCTTCTGAAGAAAGCTGAC
ATTTTAGGAGTATTAAGTCATCTGTCGTTAAGGAGCAGCAAGAATATATTATGATTGTATCACATGTTCCAGAAGAGCATTACCCCTTAC
ATAGAAAGCTCCTTGGAGATTTCATGATGTTGGATGAACATCAGTTTATCCTTATACATCCCTATGAGCTATAATTATCCTCATTTGATA
CTTGAGGAAACTGAAGTGACTTGCTCCAAAGTTGACTACAAAAACATTGCAGTTTGAGGCTTAGGTTGTAATCAGGTAATTTTGGTCTTG
GACAGTAAGGGAAAATCCATAATACATAAAACACAAAAGTTTAGAAAGGGGGGGAAGTTGAGCTAGCAATGGGCATTTCTATTATTTAAG
TTACATATCAGTTTCCAGGAATATTTTTCAAATGGGACAAACTAAAAAGTTGAGGACTAGAGCATCGTAGTGTCTAAGTGCACCTAATAA
CTTAATGCATGTGCACACACCCTCAGTTAATTTGTAAGAGAGTGACTTCTCATTGTTATTTGTGGAGAGGCTAATTATAGTAGCTTCATT
CTTTATTTTCTGTGTTCTTAAATTTTTTTTTACATTTGAAAGTATGAAAATACTATTTTTGACACTTTACTGATACTCAGGGATTAAAAG
TTAAATTTTACTGACTGTAGCAGCAGGTAAATCTCTTAAATTTACTCAGGTTTCCTATCCTTTGCCTCCATATTTAAGAAAATATAGAAT
GCCTGCCAGGGAAATATATAAAAATAAAAATTTCAAATACAATTTTAAAATACCAATTTGTAAATAAACCAATTTTACAAACTAAAATAT
TGTGTCTTTCCTTGCTTTTTATCCCAATTTATCTCCCCTCCTAAGTTTGAGGAGTTTTATATATTAAGGCTATTTCTTCATTTGTAAAAA
TGAAGTATGCTATTTGCAAAGCAAAAGCCCATGAAAAGCCCCAAATCATTTAAGTAAAGCTTACTGAATTGTTTTCAATTGTTTTGGGAG

>84280_84280_1_SMS-DYRK2_SMS_chrX_21958991_ENST00000379404_DYRK2_chr12_68043577_ENST00000344096_length(amino acids)=601AA_BP=16
MAAARHSTLDFMLGAKGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQV
QQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRIL
EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK
RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP

--------------------------------------------------------------
>84280_84280_2_SMS-DYRK2_SMS_chrX_21958991_ENST00000404933_DYRK2_chr12_68043577_ENST00000344096_length(transcript)=8751nt_BP=301nt
GTTTCCACCATTAGCGAGGCCTCACACCCGGCGCTCCAAGTTCGGGGCTGGAGGCGTCCCGGCTTCCTCCCTCCCGGAGCGGGACCGGCC
CCGCCCCCGCGCCCCGGGTCGCTCCCGGCGGCCCCTCCCACCTCCTAGTCCTGGCCTCCCCGGGCGCAGCACACTCCCAGCCGGCCGCAG
CCTGACACGCCGCGCGGCCCCCCAGTCTCCCGCGGCTGCTCCCCCAGGCATGGCACAGGGCCTCGCCTCACTATGGCAGCAGCACGGCAC
AGCACGCTCGACTTCATGCTCGGCGCCAAAGGCCGAGGTGGGGACAGCGCCGTTCGTCAGCTTCAGGCTTCCCCGGGGCTCGGTGCAGGG
GCCACCCGGAGCGGAGTGGGGACTGGCCCGCCCTCCCCCATCGCCCTGCCGCCTCTCCGGGCCAGCAACGCTGCCGCCGCAGCCCACACG
ATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTCGGCAGCCACGCTCACGGACAGATCCAGGTTCAACAGTTGTTTGAGGAT
AACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAGTGGGCAAAACGGGCTTGCCAGTGGTGCCAGAGCGGCAG
CTGGACAGCATTCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGGAAGGCATGGGGAAGGTGAAAGCCACCCCCATGACACCT
GAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCATGAGATTTTCAGCTACCCTGAAATATATTTCTTGGGTCTA
AATGCTAAGAAGCGCCAGGGCATGACAGGTGGGCCCAACAATGGTGGCTATGATGATGACCAGGGATCATATGTGCAGGTGCCCCACGAT
CACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTTGGGCAGGTGGTCAAGGCCTACGATCACAAAGTCCACCAG
CACGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCAGCGGAGGAGATCCGAATCCTGGAACACCTGCGGAAGCAG
GACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCCGCAACCACATCTGCATGACGTTTGAGCTGCTGAGCATG
AACCTCTATGAGCTCATCAAGAAGAATAAATTCCAGGGCTTCAGTCTGCCTTTGGTTCGCAAGTTTGCCCACTCGATTCTGCAGTGCTTG
GATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAACATTTTGTTAAAGCAGCAGGGTAGAAGCGGTATTAAAGTA
ATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTACACGTACATCCAGTCGCGTTTTTACCGGGCTCCAGAAGTGATCCTTGGG
GCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAGAGCTCCTGACGGGTTACCCCCTCTTGCCTGGGGAAGAT
GAAGGGGACCAGCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGAAACTGCTGGATGCATCCAAACGAGCCAAAAATTTTGTG
AGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGCTCTGTGGTCCTAAACGGAGGCCGTTCCCGGAGGGGGAAA
CTGAGGGGCCCACCGGAGAGCAGAGAGTGGGGGAACGCGCTGAAGGGGTGTGATGATCCCCTTTTCCTTGACTTCTTAAAACAGTGTTTA
GAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCCTGGCTGAGGAGGCGGTTGCCAAAGCCTCCCACCGGGGAG
AAAACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATATCCAAGTTACCTCCACCTTCTAGCTCAGCTTCCAAACTG
AGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGACAGTGTTGCCAAAACTTGTTAGCTGAGCTCACGTCCCC
TGATGCTGGTAACCTGAAAGATACGACATTGCTGAGCCTTACTGGGTTGAAAAGGAGTAGCTCAGACCTGTTTTTATTTGCTCAATAACT
CTACTCATTTGTATCTTTTCAGCACTTAATTTTAATGTAAGAAAGTTGTTCATTTTGTTTTTATAAAATACATGAGGACAATGCTTTAAG
TTTTTATACTTTCAGAAACTTTTTGTGTTCTAAAAGTACAATGAGCCTTACTGTATTTAGTGTGGCAGAATAATAACATCAGTGGCAGGC
CACTGATTACTTCATGACTGCCACGCATTTACAGATTGGTGTCAAAGACATTCACTATGTTTTTATGGTTCATGTTATATCCTCCCCAGG
GTGACAGCCCCTTAAGGCCCTCCTTTTCCCTCCATGCTCCAGGTCCATGCACAGGTGTAGCATGTCCTGCTTCCGTTTTTCATAAATTAA
TCTGGGTGTTGGGGGTAGTGGGAGGAGAACGGTCAGAATCAAAGTGACATTCTAAGAAAAACTGTACCTTAGAGATTTTCCTCTAGTGCT
CAAACAAATACAAAATAAGATCCCCAAGGTTTAAACTGCCCAGTTAGCATTCTGACATTCTAAAAGCCGGCAAAGCAGCTTTTAGTGGAT
AAATGGGAATGGAAACGTGTGTGTTCCTCCAAATTTTCTAGTATGATCGGTGAGCTGTTTTGTAAAGAAGCCTCATATTACAGAGTTGCT
TTTGCACCTAAATTTAGAATTGTATTCCATGAACTGTTCCTCCCTTTTCTCTGCTTTTCTCCTCTCTGTTCCTCTTTTAATACCACACGT
CTGTTGCTTGCATTTAGTTTGTCTTCTTCCTTCAGCTGTGTATCCCAGACTGTTAATACAGAAAAGAGACATTTCAGCTGTGATTATGAC
CATTGTTTCATATTCCAATTAAAAAAAGAACAGCAGCCTAGCTACTTAAGGTGGGGATTTCCATAGTTCCAAAGAAGATTTAGCAGATTA
GAGTGAGTTCACACTTTTCAGGTGCCACTGTAAGGTTCTCTCAGCCTGGGAAACTATCAACTCTTTCTTTAAAAAGAAAGAGGGTTGAAA
ATCCTCTGGACGAACAGAAGTCACTTTGGCTGTTCAGTAAGGCCAATGTTAACAACACGTTTAGAGGAGGAAAAGTTCAACCTCAAGTTA
AATGGTTTGACTTATTCTTCGTATCATTAGAAGAACCCCAGAGATAGCATTCCTCTATTTTATTTTACTTTCTTTTGGATTGCACTGATT
GTTTTTGTGGGAATGACACTTTATCTGGCAAAGTAACTGAGAGTTTGGTAAAAGAATATTTTCTTCTCTGAATAATAATTATTTTCACAG
TGAAAATTTCAGTATTTTATCACTAATGTATGAGCAATGATCTATATCAATTTCAAGGCACGTGAAAAAAATTTTTTAGTATGTGCAATT
TAATATAGAAAGATTTCTGCCTGTTTGGACAATAGGTTTTGGGTAGTACAGATTAGGATAAGTAAGCTTATATATGCACAGAGATTATTG
TATTACCTGTAAATTGATTTACAAGTACTTAAAAGCGTGGTCCCCAGTGAGGCCAAGAAAGTTTCCGGTTAAGTTCTTTAATAATAATCC
TACAGTTTATCTTAAGAAAAAAAAAAAGGTTTGAAAAAAACACTTTAATTTAGGCTTCGTTGGTTGATGGTGGAAAAAAATGCTCAGGAA
ATATTTCAGATATTTGCCAAAAAACCAGTAATAAGGTTACCTTATTAAAATAGTGATATTTGCTTTACTATTTAAGGTGTCACTGATAAA
TTAATTTGTACTTCTGTGTTTAGAAATTATAGCTTCTTTTCCCTTAGTCAAATTTTTTAGCATATTATACACATTTCTGTGTAATCTGTG
GAAGTGCAATAATATGTTAGTAAGTTACATTTTAAATAATGCTCATGTGACAATACTCCCAATCAATGGCTTATAGAATTTAAAGATCTG
TATATTAGATTTTGGCTTAAAGGCATGAGAAGTATAAGACTTGGTTTGGTGGCTTTGTAAGACCACCAGCCTCTTAATGATGGTTAGCTT
CTTTAGGTCATTAAATCAATAAAAACATATAATGCTGTTTTGCTCTTCTAATGCTCCTCTTCCATTTCCAGTTATCTTCACATTTACATT
TAAATATACAAACCTGAGCCTGCCATTATTAATTTCCCTATAAAATGACGATACATGTGAACATTTATAAATGGACTAATACTGCTTGTC
TTTCCCCCACCGCACAAAACTGGTTCTTAAGATGCCAGCAATGAATTTGAGACTATCTTTATTTATAAATGGAAACCGGAAACTTTTATA
CCAAACTATAATAATGTGCAGCACTGTAGGGCTTTTTTTTTTTTCCCTCCAAATACAGTGAAATTTTTTTATTCACAAGAGCTGCCACAT
CTCAGCATTTAGTAATAGAGCTGCTTTAATAAAATTCTAGTTTGATTGTCATGTCAAAAAAAGAAAAATGTTGCATCTTTGTGATTTTAA
AACATAAATTAATGAAGGCTCTGATAGGCTATTAGGAGTTGGCTTGGAAACAGTTTTTGGTCTCACAGGTTACCATTGTTTGGGGATGTC
TGAGCTGTTTTCAGATCTAGGAATAGCACAGTGTTGTCTTGTCTTTGGCAGTCTCATTTGGCTCTGTTTCTTGCACCACCAGCGTGTTCA
TTACCACTTAAATATATTGCTACAGCAGTGGAACAACAGAGTGGTGCAAGACACTGTAGATTAACGGTAGAGGAGAAATTGTGCCCTTAG
TGTTAACAATGTGCCTTTTGTTCTGAATGCCATGTTGTAGGGCATGCATTTTTTGGCCTCTTTAACTCTTCGAATTCTAGTCAGTAAGAA
TGGAACCCATCTCTGCAAAGATACATCTGTCTTAAATATCTAGTTACAGGCCTTAATAGAAACCATAAGGCATGACTCATCTTCAGGCAC
TGAAAAAAGATAACCATCAGGTAGTGTTACACAAGGACTTCCTATATTTAAGGGGTTAAAGATGGTCTTTGTTGTATCTTAACATCAGAC
TGATTTTTACATTTTTTTTTTGTTATGCTAACACTAGACAAAAATCAACTGTATTTGTAAAAATTTACCTCAAACCATTTAATTTTATAG
TGTGATTAATCCCAGGGCATTTGGTATGAACCAAAGTGCATTCCTTTTATATGTGCCTGGCTCTAGTAAGGATGGCCAGGGATTTTTACA
ATTTGGGTGCAAGGCACTTAAGCCACTTTTAAACTTAATGGGTGGTTTGGGGTCGTGTTAAATGACTCCATCAGAATGTTAGAAAACACT
TTAGGCATCAGTAGCATTGGGCCATATTGGAATCCTAAAGTGTGAATTATTTTAAGGAGAGCATTCATTTTTGTAATTTTTTTCATCAAA
AATATTTCTGGTAAGCAGAAGACTTTTTAAAAAAACTGATCTGGTCTCGGTAAAGGTTTTAATATTGCCCAACATAATGCTGTAATAGCA
TTAAAAAAAGTATTTGTGAACTCTGTTTCTTAGGGGCTTGTACATCTCTCTGCTATGGACATACATAAAATTAATTGTAATTATACTCAG
CTCAACTGCTACAGTTCTGTCTAGGCAGTGGCTTGGGTTTTTATCGAGCAACAACTTAGACACGTGACTGTAATATGCTGCAACTGTGTG
TACTGAAAATATGTGAAAATGGTTGAATGTGGACTGTGTATATATGTATGTAAAAATTTCTGTGAGATGCTGCTGTCGCCACTTAACATT
AAATATGTTCTAGTGGATTTTAATCCTAGTGGCCAGTTCTATGATACTGTATGTATTATACAGCTGATGACAGGAGTAAGACTGTTTAGT
GAATATCTGTTAAATTTTATTGTTGTGGCCAGAGATAATTTCAGAATAAAATTTTAATGTCCTACCTTACTTCTCTCCCCTTTCTAACTA
TAATTTAACTCCTGATCTATTTCTGGTATTATCCTTTGTCAATTAGCCTGGAGAGGGTTTAGAATGCAAAATGGATAGCTCTATATCAGG
GTCTTGAGAAGTTAAAATAATTCATTCTACTAGTTTGTTCATAGCAATACTTTATTAGTTCAATATAAGTATGCAGATTCCAAGTGGAAA
AACAAAGGTTTTAGTAAGTAGTTCTTGCTTTTCCCAGGATATTCTATTCCTTCACCTGTCAGATTTTTATGTTAACTTTTTTATATATAG
CCTCTGCTGTGTTCTTTATTATGCTAGAGCTTCATATCTTCTTTTATTTTAACCTTCACAATGATAGTTAAGCTGGGGGAGCAGAACCTG
TCAATTATTCCCCACCAGTCTTCATTCTTTTCTCTGCACAAGTTCTGGTAAATTATTCTAATGTGCTCTAACCAGTTCCACCCAATGTTT
TTTAATGCTTATGAGTTTGCAGTTTTTGTACTTGGTGGTCTCTGTGGTTCACATTTTTTTGTGTTGTAGTGTCTCCTGCCTCGGTTGGCT
CAGAAAATAAGGCCTAGGAACTGCAATTAGCTCATGATTTGTCAAGTTCAGTTAGTACCAAGCTAAGAGTTTACTTACAGATGACAGCAA
GCAGATGCTCTAGTAATTCGTCAGACATTGCAGGGATATTGTGTAGTCAGATATTACCCTCTTGTGGAAAGAACTACCTCACATCATTAT
TTATTTCCCTTCTGTTACCAACAGCCAAGGAATTACTTAGTGTGGCTCCCTGCATCAATACTGGGATATGCTTAAACAAGGGAATGCCAT
AAGAGTTCCCAATTGCCTCGTCATAGCCTGGGCCATAGATTTTTGTTACTGCTAATCTTGCTTCTTAAAGTTCACACCCAGTGCAAAAAA
CCCAATCAGCAAACTAACCCCAAAATCCAATATATTTAGAAATGTAAGTGTTAAGAGATGTGCATTATGTACAAAATTGAAAATTGGTGC
TAAAGTGGCAATGTCAATTTAAAATTTCTTGTCCAGATCTGACTGACTGACTCAGGAGATTATAGTTCCTACTCATTCTCTTTCCTTTTA
TCAGATCTTTCAAAAGCGCTTTTTAAAATTGATCAATGTGCAATTCTGTTTGAGTCTCTACAGTCCTATCCCTTTTGGAATGAACAGCTA
CACAAATAAATATTCTTGGAACTTCGAAGTTGTCTTCAAACTAGCTCTAGAAAATGTCCCTAGTTGACATTAGTGTTGGTCTGTTAGAAG
GGGAAATTGATTTGACTGCTTCATGTTTTGAAAAGAGCATTAAGAGGGATTTGAGGAAGGTATATGTGGCTTTCTTTTTTTTTCTTAAGT
TTGAATTACACTTGATTTCCTTTGGGTTATTAGGCAGATAAACCCTTGTCATTAGTAATACTTAGCACTGTCCAAAATGAAAAATGACTG
CCAGTGTGTTGCACATACATAAGAAAATTACATCTTACTGCGAAGTCTTTGGTTTGTTTCCTTATTTGGTTTGACTTTGACTTACTATTT
TGCTATGGTCATATCCTTAATATCTGCGGTACATTTCATATATATATATGGGGTGGGAGCATAATTGCCATTCCCATGTGTCTCAAGGAA
GCTTAATGAGGAAACTAATGAGTTAATATTAACTCTTCTGAAGAAAGCTGACATTTTAGGAGTATTAAGTCATCTGTCGTTAAGGAGCAG
CAAGAATATATTATGATTGTATCACATGTTCCAGAAGAGCATTACCCCTTACATAGAAAGCTCCTTGGAGATTTCATGATGTTGGATGAA
CATCAGTTTATCCTTATACATCCCTATGAGCTATAATTATCCTCATTTGATACTTGAGGAAACTGAAGTGACTTGCTCCAAAGTTGACTA
CAAAAACATTGCAGTTTGAGGCTTAGGTTGTAATCAGGTAATTTTGGTCTTGGACAGTAAGGGAAAATCCATAATACATAAAACACAAAA
GTTTAGAAAGGGGGGGAAGTTGAGCTAGCAATGGGCATTTCTATTATTTAAGTTACATATCAGTTTCCAGGAATATTTTTCAAATGGGAC
AAACTAAAAAGTTGAGGACTAGAGCATCGTAGTGTCTAAGTGCACCTAATAACTTAATGCATGTGCACACACCCTCAGTTAATTTGTAAG
AGAGTGACTTCTCATTGTTATTTGTGGAGAGGCTAATTATAGTAGCTTCATTCTTTATTTTCTGTGTTCTTAAATTTTTTTTTACATTTG
AAAGTATGAAAATACTATTTTTGACACTTTACTGATACTCAGGGATTAAAAGTTAAATTTTACTGACTGTAGCAGCAGGTAAATCTCTTA
AATTTACTCAGGTTTCCTATCCTTTGCCTCCATATTTAAGAAAATATAGAATGCCTGCCAGGGAAATATATAAAAATAAAAATTTCAAAT
ACAATTTTAAAATACCAATTTGTAAATAAACCAATTTTACAAACTAAAATATTGTGTCTTTCCTTGCTTTTTATCCCAATTTATCTCCCC
TCCTAAGTTTGAGGAGTTTTATATATTAAGGCTATTTCTTCATTTGTAAAAATGAAGTATGCTATTTGCAAAGCAAAAGCCCATGAAAAG
CCCCAAATCATTTAAGTAAAGCTTACTGAATTGTTTTCAATTGTTTTGGGAGAAATGTAACTAATTATAAGCAATTTATGTGGACCAGCA

>84280_84280_2_SMS-DYRK2_SMS_chrX_21958991_ENST00000404933_DYRK2_chr12_68043577_ENST00000344096_length(amino acids)=601AA_BP=16
MAAARHSTLDFMLGAKGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQV
QQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRIL
EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK
RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SMS-DYRK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SMS-DYRK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SMS-DYRK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source