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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SMU1-FAM219A (FusionGDB2 ID:84297)

Fusion Gene Summary for SMU1-FAM219A

Fusion gene summary

Fusion gene information	Fusion gene name: SMU1-FAM219A
	Fusion gene ID: 84297
		Hgene	Tgene
	Gene symbol	SMU1	FAM219A
	Gene ID	55234	203259
	Gene name	SMU1 DNA replication regulator and spliceosomal factor	family with sequence similarity 219 member A
	Synonyms	BWD\|SMU-1\|fSAP57	C9orf25
	Cytomap	9p21.1	9p13.3
	Type of gene	protein-coding	protein-coding
	Description	WD40 repeat-containing protein SMU1DNA replication regulator and spliceosomal factorbrain-enriched WD-repeat proteinfunctional spliceosome-associated protein 57smu-1 suppressor of mec-8 and unc-52 homologsmu-1 suppressor of mec-8 and unc-52 protein h	protein FAM219Auncharacterized protein C9orf25
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IW50
	Ensembl transtripts involved in fusion gene	ENST00000536631, ENST00000397149,	ENST00000297620, ENST00000379078, ENST00000379080, ENST00000379081, ENST00000379084, ENST00000379087, ENST00000379089, ENST00000445726,
Fusion gene scores	* DoF score	9 X 7 X 7=441	5 X 4 X 3=60
	# samples	9	5
	** MAII score	log2(9/441*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SMU1 [Title/Abstract] AND FAM219A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMU1(33053121)-FAM219A(34405962), # samples:2
Anticipated loss of major functional domain due to fusion event.	SMU1-FAM219A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SMU1	GO:0000398	mRNA splicing, via spliceosome	28781166

Fusion gene breakpoints across SMU1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM219A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-D1-A3DG-01A	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-

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Fusion Gene ORF analysis for SMU1-FAM219A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000536631	ENST00000297620	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
Frame-shift	ENST00000536631	ENST00000379078	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
Frame-shift	ENST00000536631	ENST00000379080	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
Frame-shift	ENST00000536631	ENST00000379081	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
Frame-shift	ENST00000536631	ENST00000379084	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
Frame-shift	ENST00000536631	ENST00000379087	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
Frame-shift	ENST00000536631	ENST00000379089	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
Frame-shift	ENST00000536631	ENST00000445726	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000297620	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000379078	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000379080	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000379081	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000379084	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000379087	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000379089	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-
In-frame	ENST00000397149	ENST00000445726	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000397149	SMU1	chr9	33053121	-	ENST00000379081	FAM219A	chr9	34405962	-	4568	1341	51	1787	578
ENST00000397149	SMU1	chr9	33053121	-	ENST00000379087	FAM219A	chr9	34405962	-	4565	1341	51	1784	577
ENST00000397149	SMU1	chr9	33053121	-	ENST00000379080	FAM219A	chr9	34405962	-	4616	1341	51	1835	594
ENST00000397149	SMU1	chr9	33053121	-	ENST00000379084	FAM219A	chr9	34405962	-	1885	1341	51	1778	575
ENST00000397149	SMU1	chr9	33053121	-	ENST00000379089	FAM219A	chr9	34405962	-	4616	1341	51	1835	594
ENST00000397149	SMU1	chr9	33053121	-	ENST00000445726	FAM219A	chr9	34405962	-	4618	1341	51	1838	595
ENST00000397149	SMU1	chr9	33053121	-	ENST00000297620	FAM219A	chr9	34405962	-	4562	1341	51	1787	578
ENST00000397149	SMU1	chr9	33053121	-	ENST00000379078	FAM219A	chr9	34405962	-	1762	1341	51	1754	567

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000397149	ENST00000379081	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.000906314	0.99909365
ENST00000397149	ENST00000379087	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.000853846	0.9991461
ENST00000397149	ENST00000379080	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.000838157	0.99916184
ENST00000397149	ENST00000379084	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.00134852	0.99865156
ENST00000397149	ENST00000379089	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.000838157	0.99916184
ENST00000397149	ENST00000445726	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.000892413	0.99910754
ENST00000397149	ENST00000297620	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.00089727	0.9991027
ENST00000397149	ENST00000379078	SMU1	chr9	33053121	-	FAM219A	chr9	34405962	-	0.001532279	0.99846774

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Fusion Genomic Features for SMU1-FAM219A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMU1-FAM219A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33053121/chr9:34405962)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FAM219A Q8IW50
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

40_92

430

514.0

Domain

CTLH

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

6_38

430

514.0

Domain

LisH

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

212_253

430

514.0

Repeat

WD 1

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

262_303

430

514.0

Repeat

WD 2

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

305_346

430

514.0

Repeat

WD 3

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

347_386

430

514.0

Repeat

WD 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

395_436

430

514.0

Repeat

WD 5

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

440_479

430

514.0

Repeat

WD 6

Hgene

SMU1

chr9:33053121

chr9:34405962

ENST00000397149

482_513

430

514.0

Repeat

WD 7

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Fusion Gene Sequence for SMU1-FAM219A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>84297_84297_1_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000297620_length(transcript)=4562nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATG
GGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTCATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGAC
CAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACGGACAGCGATGATGACTTTGACATGTCTAGATACTCCTCCTCCGGCTACTCC
TCTGCTGAGCAGATCAACCAAGATTTGAACATCCAGCTGCTGAAGGACGGCTACCGGTTAGATGAGATCCCCGACGACGAGGACCTAGAC
CTCATCCCCCCCAAGTCCGTGAACCCCACGTGCATGTGCTGCCAGGCCACGTCCTCCACCGCCTGCCACATTCAGTAGCGGGCGGGGCCA
CTGCGGTCGCCGGGGCGGGGCCGCCAAGGGCCGGGTAGGACGGGCAGAGGCCGACCCCTTCCCAGCTCGTCTGCCTGCCCCCGGCCCCGC
GCCCCTACAGCCGCCAACCTCGTATAACAGTCATTGCTTCCTCCTATGGTAGGACGTGTACCTCTGTGTGTTCATGGAGCTGGAGAAACC
AAAACTGGGTCTCTCTCCACCCGGGAGCTGAGGAGGGGTGGGGGCCGTTTGTTCAGTTACCTGGGGGAACCTCACCCAGCACCCTGCCCC
GCTTCCCAGGGCTGGCCAAGAGAGAAGACTGGACGGCAGGGAGGTCAACATTAACGAGTGGGGGGATCACAAAGCCAGGGGCTTGGCCCC
ACCCCAGCGAAGCCATGAACTCCCAAGCCCCGGCCTCAGCCTAACCAGGAAAGGGGCTCGGAGGGAGAAAGGCCCAGGGCAGTGGGGACG
GGTCCCAGCACCTCGGAGCCCCCTTCACACGCCCCCTACCGGCCCATGTTTCTATTTGCATTTCCCCCTCCTCAGATGGGAAGCCTGGCA
AAGCTGCCCAACCGGGTAGTGCCCCTCACCCATCGGATCACTGCCTTCTTCCTCCTCTTGCCCCATTCACCCGCTTCCTTGCACTCTGGG
AGTGGGGCAGGGTAAGGTGGGCCTTACAGACAGGCTGAGGTTTGGGTGGTGTGATCTGTCCTAATTGGCCCCTCACCAATGCATCTATCT
GTCTGCCACCAGCCCACCCCACCCTGCCCCCACCCTCACCCACGCTTCTGCTCATTGGTCTCAATCCCAGCCTGGAAGCAGGGAGTAAGG
CTGGACTCCAATGGCCCATTCCCCTCACCCCAGCCCAAGACGTGGGAGGCTGCTTCCCAGTAAGAATCCAGGAGCAAGCTTTGGTGAATC
CAGTGGGCTGAGTGGCTCTATGGATGTGGTTGTTTGGATGTGGTAGGGAGTGCTTAGCAGAATGTGTGTGTATCTCTGAGGCTGTCAGGG
GGTGGGTGGGTGTGTGTCTCTGTTGGACCTGTCTCTCCTCAGTCTATTCCTGTCATAGATGTGGGTGTCCCTGGTAGGGAAGTGCCTGTG
TGGTCTGTTTACAGTGCAGAAGGCGGCTCAGCAGTGCAATGGGCTGACAGCCTTGGACCGGGAGTCAGAAGCCTGGGTTCTGGTTGTAGC
TCTGGCCCCTCCCTGTGATCTTCAACAAGCCACTTGCTTTCTCTCGTCTTCAGTTTCCTCAACTAGAAAATGAACAGCAGCTGAAATTAT
GTTGAAGATCCTTTTATACCTGAAAGAGTTTCTTCATAGAAATTTCTGTGGTGGGGAGGGGGCAATCTCTGTGTGTCTCAGTATACCTAA
AGGTTGGGGTGGGGCGGAGTTGTGTGTCTCTGTAGAAAGGCGAAGGGGCAGTTCCTATCAGGACTGTGTATGTCTGAGCACATGTGGCTC
TGTTTGGGATTACGTGTTTGTCTGTGAATGTGTGTGTGTGTTGGAGGGTTGTCTATTGTGTGTGGCTGTATAGGGTGTCTGTAGATCAAG
ATGTGTATACAGCTGCTTCTGCTATTGCTGGTTTGGGGGAGGGGACTGGAAAGCTGAGACTGAAAATCAAGAGGGAAGAGGTGAGGAAGG
CCCACCCCTGGGGCTGGGCAGTGTAGACCTGCCACCGTGTGAAGAAAAATGAAAGCACAGATAGCCTAAGACTGCACAGGCCTGTGCCCA
CATACCTTATAGCACAGGCCCAGGTGGATCATCTCATGCTAACACCCCACATGTGCTGGTGGATCCACTCCCATGGATCCACTCACATGC
TGCAGGCATGCAGTAGACTCACCCACAGCCCACTCTCTGGACACCAATCCTGGGAGGTGGGAGCTGGAATGGGGAGCAATGAGAGGAGGG
AGTGAGACTGTTGGCTTAGGAAGGGTGGTACCTCTCCCTGCATCATACCCAGGAACTGCCAGCTCCAAAATATTGGGGTACAGCTCACCA
CCCCCCACTCCGCCAACCCATTCCTACCTCCTCTAGTGCAGGGACCCAAGTTAGATGATGAGAAAATGCCAAACAAAGGGAGGCAAGGAC
AGAGAAGGTACCTGCAGGACCCACAAGGCCCATACTGGCCCCCATCTGAACCCACCTCTCCCACCCAGATCAACATCCCCCCAACCCCTG
TGCCCCCATCATCTGGACCCCAGAGCCAGCCCTCCCACTACCACCACCACCACCCCGGGGCTCCTTGGCTCACCTTTCTAGAACATGGGT
ACCTCCTCTTTTTGGGGGCTCATTTAGACTGCTGCCTTTGCTGCTGACTTGCAGTGTGACTCGGGCCCATTGTTCAATCTCTGTGGCCCT
GAGACACCAGGGAAAATCTCCCCCCCCACAGGACATACTAGTTCCCTGGCAGGCAAGGGCTTCCAACTGAGGCAGTGCATGTGTGGCAGA
GAGAGGCAGGAAGCTGGCAGTGGCAGCTTCTGTGTCTAGGGAGGGGTGTGGCTCCCTCCTTCCCTGTCTGGGAGGTTGGAGGGAAGAATC
TAGGCCTTAGCTTGCCCTCCTGCCACCCTTCCCCTTGTAGATACTGCCTTAACACTCCCTCCTCTCTCAGCTGTGGCTGCCACCCAGCCA
GGTTTCTCCGTGCTCACTAATTTATTTCCAGGAAGGTGTGTGGAAGACATGAGCCGTGTATAATATTTTTTTTAACATTTTCATTGCAGT

>84297_84297_1_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000297620_length(amino acids)=578AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREEKQR
ELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYSSAEQINQDLNIQLLKDG

--------------------------------------------------------------
>84297_84297_2_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379078_length(transcript)=1762nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGGTGAGTCAGTAGCCATGAATTACAAACCATCCCCGCTCCAAGTGAAGCTG
GAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATGGGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTC
ATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGACCAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACG
GACAGGTGTGTATGGGGGCTTGGGGGTAGCTGGGCAGCCCAAAGGAACCTGTATAGCACAAGTGGGCTGTACAGGCCACACCTGCTATAT

>84297_84297_2_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379078_length(amino acids)=567AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREGESV
AMNYKPSPLQVKLEKQRELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDRCVWGLGGSWAAQRNL

--------------------------------------------------------------
>84297_84297_3_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379080_length(transcript)=4616nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGGTGAGTCAGTAGCCATGAATTACAAACCATCCCCGCTCCAAGTGAAGCTG
GAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATGGGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTC
ATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGACCAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACG
GACAGCGATGATGACTTTGACATGTCTAGATACTCCTCCTCCGGCTACTCCTCTGCTGAGATCAACCAAGATTTGAACATCCAGCTGCTG
AAGGACGGCTACCGGTTAGATGAGATCCCCGACGACGAGGACCTAGACCTCATCCCCCCCAAGTCCGTGAACCCCACGTGCATGTGCTGC
CAGGCCACGTCCTCCACCGCCTGCCACATTCAGTAGCGGGCGGGGCCACTGCGGTCGCCGGGGCGGGGCCGCCAAGGGCCGGGTAGGACG
GGCAGAGGCCGACCCCTTCCCAGCTCGTCTGCCTGCCCCCGGCCCCGCGCCCCTACAGCCGCCAACCTCGTATAACAGTCATTGCTTCCT
CCTATGGTAGGACGTGTACCTCTGTGTGTTCATGGAGCTGGAGAAACCAAAACTGGGTCTCTCTCCACCCGGGAGCTGAGGAGGGGTGGG
GGCCGTTTGTTCAGTTACCTGGGGGAACCTCACCCAGCACCCTGCCCCGCTTCCCAGGGCTGGCCAAGAGAGAAGACTGGACGGCAGGGA
GGTCAACATTAACGAGTGGGGGGATCACAAAGCCAGGGGCTTGGCCCCACCCCAGCGAAGCCATGAACTCCCAAGCCCCGGCCTCAGCCT
AACCAGGAAAGGGGCTCGGAGGGAGAAAGGCCCAGGGCAGTGGGGACGGGTCCCAGCACCTCGGAGCCCCCTTCACACGCCCCCTACCGG
CCCATGTTTCTATTTGCATTTCCCCCTCCTCAGATGGGAAGCCTGGCAAAGCTGCCCAACCGGGTAGTGCCCCTCACCCATCGGATCACT
GCCTTCTTCCTCCTCTTGCCCCATTCACCCGCTTCCTTGCACTCTGGGAGTGGGGCAGGGTAAGGTGGGCCTTACAGACAGGCTGAGGTT
TGGGTGGTGTGATCTGTCCTAATTGGCCCCTCACCAATGCATCTATCTGTCTGCCACCAGCCCACCCCACCCTGCCCCCACCCTCACCCA
CGCTTCTGCTCATTGGTCTCAATCCCAGCCTGGAAGCAGGGAGTAAGGCTGGACTCCAATGGCCCATTCCCCTCACCCCAGCCCAAGACG
TGGGAGGCTGCTTCCCAGTAAGAATCCAGGAGCAAGCTTTGGTGAATCCAGTGGGCTGAGTGGCTCTATGGATGTGGTTGTTTGGATGTG
GTAGGGAGTGCTTAGCAGAATGTGTGTGTATCTCTGAGGCTGTCAGGGGGTGGGTGGGTGTGTGTCTCTGTTGGACCTGTCTCTCCTCAG
TCTATTCCTGTCATAGATGTGGGTGTCCCTGGTAGGGAAGTGCCTGTGTGGTCTGTTTACAGTGCAGAAGGCGGCTCAGCAGTGCAATGG
GCTGACAGCCTTGGACCGGGAGTCAGAAGCCTGGGTTCTGGTTGTAGCTCTGGCCCCTCCCTGTGATCTTCAACAAGCCACTTGCTTTCT
CTCGTCTTCAGTTTCCTCAACTAGAAAATGAACAGCAGCTGAAATTATGTTGAAGATCCTTTTATACCTGAAAGAGTTTCTTCATAGAAA
TTTCTGTGGTGGGGAGGGGGCAATCTCTGTGTGTCTCAGTATACCTAAAGGTTGGGGTGGGGCGGAGTTGTGTGTCTCTGTAGAAAGGCG
AAGGGGCAGTTCCTATCAGGACTGTGTATGTCTGAGCACATGTGGCTCTGTTTGGGATTACGTGTTTGTCTGTGAATGTGTGTGTGTGTT
GGAGGGTTGTCTATTGTGTGTGGCTGTATAGGGTGTCTGTAGATCAAGATGTGTATACAGCTGCTTCTGCTATTGCTGGTTTGGGGGAGG
GGACTGGAAAGCTGAGACTGAAAATCAAGAGGGAAGAGGTGAGGAAGGCCCACCCCTGGGGCTGGGCAGTGTAGACCTGCCACCGTGTGA
AGAAAAATGAAAGCACAGATAGCCTAAGACTGCACAGGCCTGTGCCCACATACCTTATAGCACAGGCCCAGGTGGATCATCTCATGCTAA
CACCCCACATGTGCTGGTGGATCCACTCCCATGGATCCACTCACATGCTGCAGGCATGCAGTAGACTCACCCACAGCCCACTCTCTGGAC
ACCAATCCTGGGAGGTGGGAGCTGGAATGGGGAGCAATGAGAGGAGGGAGTGAGACTGTTGGCTTAGGAAGGGTGGTACCTCTCCCTGCA
TCATACCCAGGAACTGCCAGCTCCAAAATATTGGGGTACAGCTCACCACCCCCCACTCCGCCAACCCATTCCTACCTCCTCTAGTGCAGG
GACCCAAGTTAGATGATGAGAAAATGCCAAACAAAGGGAGGCAAGGACAGAGAAGGTACCTGCAGGACCCACAAGGCCCATACTGGCCCC
CATCTGAACCCACCTCTCCCACCCAGATCAACATCCCCCCAACCCCTGTGCCCCCATCATCTGGACCCCAGAGCCAGCCCTCCCACTACC
ACCACCACCACCCCGGGGCTCCTTGGCTCACCTTTCTAGAACATGGGTACCTCCTCTTTTTGGGGGCTCATTTAGACTGCTGCCTTTGCT
GCTGACTTGCAGTGTGACTCGGGCCCATTGTTCAATCTCTGTGGCCCTGAGACACCAGGGAAAATCTCCCCCCCCACAGGACATACTAGT
TCCCTGGCAGGCAAGGGCTTCCAACTGAGGCAGTGCATGTGTGGCAGAGAGAGGCAGGAAGCTGGCAGTGGCAGCTTCTGTGTCTAGGGA
GGGGTGTGGCTCCCTCCTTCCCTGTCTGGGAGGTTGGAGGGAAGAATCTAGGCCTTAGCTTGCCCTCCTGCCACCCTTCCCCTTGTAGAT
ACTGCCTTAACACTCCCTCCTCTCTCAGCTGTGGCTGCCACCCAGCCAGGTTTCTCCGTGCTCACTAATTTATTTCCAGGAAGGTGTGTG
GAAGACATGAGCCGTGTATAATATTTTTTTTAACATTTTCATTGCAGTATTGACCATCATCCTTGGTTGTGTATCGTGTAACACAAATAA

>84297_84297_3_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379080_length(amino acids)=594AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREGESV
AMNYKPSPLQVKLEKQRELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYS

--------------------------------------------------------------
>84297_84297_4_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379081_length(transcript)=4568nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATG
GGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTCATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGAC
CAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACGGACAGCGATGATGACTTTGACATGTCTAGATACTCCTCCTCCGGCTACTCC
TCTGCTGAGCAGATCAACCAAGATTTGAACATCCAGCTGCTGAAGGACGGCTACCGGTTAGATGAGATCCCCGACGACGAGGACCTAGAC
CTCATCCCCCCCAAGTCCGTGAACCCCACGTGCATGTGCTGCCAGGCCACGTCCTCCACCGCCTGCCACATTCAGTAGCGGGCGGGGCCA
CTGCGGTCGCCGGGGCGGGGCCGCCAAGGGCCGGGTAGGACGGGCAGAGGCCGACCCCTTCCCAGCTCGTCTGCCTGCCCCCGGCCCCGC
GCCCCTACAGCCGCCAACCTCGTATAACAGTCATTGCTTCCTCCTATGGTAGGACGTGTACCTCTGTGTGTTCATGGAGCTGGAGAAACC
AAAACTGGGTCTCTCTCCACCCGGGAGCTGAGGAGGGGTGGGGGCCGTTTGTTCAGTTACCTGGGGGAACCTCACCCAGCACCCTGCCCC
GCTTCCCAGGGCTGGCCAAGAGAGAAGACTGGACGGCAGGGAGGTCAACATTAACGAGTGGGGGGATCACAAAGCCAGGGGCTTGGCCCC
ACCCCAGCGAAGCCATGAACTCCCAAGCCCCGGCCTCAGCCTAACCAGGAAAGGGGCTCGGAGGGAGAAAGGCCCAGGGCAGTGGGGACG
GGTCCCAGCACCTCGGAGCCCCCTTCACACGCCCCCTACCGGCCCATGTTTCTATTTGCATTTCCCCCTCCTCAGATGGGAAGCCTGGCA
AAGCTGCCCAACCGGGTAGTGCCCCTCACCCATCGGATCACTGCCTTCTTCCTCCTCTTGCCCCATTCACCCGCTTCCTTGCACTCTGGG
AGTGGGGCAGGGTAAGGTGGGCCTTACAGACAGGCTGAGGTTTGGGTGGTGTGATCTGTCCTAATTGGCCCCTCACCAATGCATCTATCT
GTCTGCCACCAGCCCACCCCACCCTGCCCCCACCCTCACCCACGCTTCTGCTCATTGGTCTCAATCCCAGCCTGGAAGCAGGGAGTAAGG
CTGGACTCCAATGGCCCATTCCCCTCACCCCAGCCCAAGACGTGGGAGGCTGCTTCCCAGTAAGAATCCAGGAGCAAGCTTTGGTGAATC
CAGTGGGCTGAGTGGCTCTATGGATGTGGTTGTTTGGATGTGGTAGGGAGTGCTTAGCAGAATGTGTGTGTATCTCTGAGGCTGTCAGGG
GGTGGGTGGGTGTGTGTCTCTGTTGGACCTGTCTCTCCTCAGTCTATTCCTGTCATAGATGTGGGTGTCCCTGGTAGGGAAGTGCCTGTG
TGGTCTGTTTACAGTGCAGAAGGCGGCTCAGCAGTGCAATGGGCTGACAGCCTTGGACCGGGAGTCAGAAGCCTGGGTTCTGGTTGTAGC
TCTGGCCCCTCCCTGTGATCTTCAACAAGCCACTTGCTTTCTCTCGTCTTCAGTTTCCTCAACTAGAAAATGAACAGCAGCTGAAATTAT
GTTGAAGATCCTTTTATACCTGAAAGAGTTTCTTCATAGAAATTTCTGTGGTGGGGAGGGGGCAATCTCTGTGTGTCTCAGTATACCTAA
AGGTTGGGGTGGGGCGGAGTTGTGTGTCTCTGTAGAAAGGCGAAGGGGCAGTTCCTATCAGGACTGTGTATGTCTGAGCACATGTGGCTC
TGTTTGGGATTACGTGTTTGTCTGTGAATGTGTGTGTGTGTTGGAGGGTTGTCTATTGTGTGTGGCTGTATAGGGTGTCTGTAGATCAAG
ATGTGTATACAGCTGCTTCTGCTATTGCTGGTTTGGGGGAGGGGACTGGAAAGCTGAGACTGAAAATCAAGAGGGAAGAGGTGAGGAAGG
CCCACCCCTGGGGCTGGGCAGTGTAGACCTGCCACCGTGTGAAGAAAAATGAAAGCACAGATAGCCTAAGACTGCACAGGCCTGTGCCCA
CATACCTTATAGCACAGGCCCAGGTGGATCATCTCATGCTAACACCCCACATGTGCTGGTGGATCCACTCCCATGGATCCACTCACATGC
TGCAGGCATGCAGTAGACTCACCCACAGCCCACTCTCTGGACACCAATCCTGGGAGGTGGGAGCTGGAATGGGGAGCAATGAGAGGAGGG
AGTGAGACTGTTGGCTTAGGAAGGGTGGTACCTCTCCCTGCATCATACCCAGGAACTGCCAGCTCCAAAATATTGGGGTACAGCTCACCA
CCCCCCACTCCGCCAACCCATTCCTACCTCCTCTAGTGCAGGGACCCAAGTTAGATGATGAGAAAATGCCAAACAAAGGGAGGCAAGGAC
AGAGAAGGTACCTGCAGGACCCACAAGGCCCATACTGGCCCCCATCTGAACCCACCTCTCCCACCCAGATCAACATCCCCCCAACCCCTG
TGCCCCCATCATCTGGACCCCAGAGCCAGCCCTCCCACTACCACCACCACCACCCCGGGGCTCCTTGGCTCACCTTTCTAGAACATGGGT
ACCTCCTCTTTTTGGGGGCTCATTTAGACTGCTGCCTTTGCTGCTGACTTGCAGTGTGACTCGGGCCCATTGTTCAATCTCTGTGGCCCT
GAGACACCAGGGAAAATCTCCCCCCCCACAGGACATACTAGTTCCCTGGCAGGCAAGGGCTTCCAACTGAGGCAGTGCATGTGTGGCAGA
GAGAGGCAGGAAGCTGGCAGTGGCAGCTTCTGTGTCTAGGGAGGGGTGTGGCTCCCTCCTTCCCTGTCTGGGAGGTTGGAGGGAAGAATC
TAGGCCTTAGCTTGCCCTCCTGCCACCCTTCCCCTTGTAGATACTGCCTTAACACTCCCTCCTCTCTCAGCTGTGGCTGCCACCCAGCCA
GGTTTCTCCGTGCTCACTAATTTATTTCCAGGAAGGTGTGTGGAAGACATGAGCCGTGTATAATATTTTTTTTAACATTTTCATTGCAGT

>84297_84297_4_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379081_length(amino acids)=578AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREEKQR
ELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYSSAEQINQDLNIQLLKDG

--------------------------------------------------------------
>84297_84297_5_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379084_length(transcript)=1885nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATG
GGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTCATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGAC
CAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACGGACAGCGATGATGACTTTGACATGTCTAGATACTCCTCCTCCGGCTACTCC
TCTGCTGAGCAGATCAACCAAGATTTGAACATCCAGCTGCTGAAGGACGGCTACCGGTTAGATGAGATCCCCGACGACGAGGACCTAGAC
CTCATCCCCCCCAACCAGGTTTCTCCGTGCTCACTAATTTATTTCCAGGAAGGTGTGTGGAAGACATGAGCCGTGTATAATATTTTTTTT

>84297_84297_5_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379084_length(amino acids)=575AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREEKQR
ELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYSSAEQINQDLNIQLLKDG

--------------------------------------------------------------
>84297_84297_6_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379087_length(transcript)=4565nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATG
GGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTCATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGAC
CAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACGGACAGCGATGATGACTTTGACATGTCTAGATACTCCTCCTCCGGCTACTCC
TCTGCTGAGATCAACCAAGATTTGAACATCCAGCTGCTGAAGGACGGCTACCGGTTAGATGAGATCCCCGACGACGAGGACCTAGACCTC
ATCCCCCCCAAGTCCGTGAACCCCACGTGCATGTGCTGCCAGGCCACGTCCTCCACCGCCTGCCACATTCAGTAGCGGGCGGGGCCACTG
CGGTCGCCGGGGCGGGGCCGCCAAGGGCCGGGTAGGACGGGCAGAGGCCGACCCCTTCCCAGCTCGTCTGCCTGCCCCCGGCCCCGCGCC
CCTACAGCCGCCAACCTCGTATAACAGTCATTGCTTCCTCCTATGGTAGGACGTGTACCTCTGTGTGTTCATGGAGCTGGAGAAACCAAA
ACTGGGTCTCTCTCCACCCGGGAGCTGAGGAGGGGTGGGGGCCGTTTGTTCAGTTACCTGGGGGAACCTCACCCAGCACCCTGCCCCGCT
TCCCAGGGCTGGCCAAGAGAGAAGACTGGACGGCAGGGAGGTCAACATTAACGAGTGGGGGGATCACAAAGCCAGGGGCTTGGCCCCACC
CCAGCGAAGCCATGAACTCCCAAGCCCCGGCCTCAGCCTAACCAGGAAAGGGGCTCGGAGGGAGAAAGGCCCAGGGCAGTGGGGACGGGT
CCCAGCACCTCGGAGCCCCCTTCACACGCCCCCTACCGGCCCATGTTTCTATTTGCATTTCCCCCTCCTCAGATGGGAAGCCTGGCAAAG
CTGCCCAACCGGGTAGTGCCCCTCACCCATCGGATCACTGCCTTCTTCCTCCTCTTGCCCCATTCACCCGCTTCCTTGCACTCTGGGAGT
GGGGCAGGGTAAGGTGGGCCTTACAGACAGGCTGAGGTTTGGGTGGTGTGATCTGTCCTAATTGGCCCCTCACCAATGCATCTATCTGTC
TGCCACCAGCCCACCCCACCCTGCCCCCACCCTCACCCACGCTTCTGCTCATTGGTCTCAATCCCAGCCTGGAAGCAGGGAGTAAGGCTG
GACTCCAATGGCCCATTCCCCTCACCCCAGCCCAAGACGTGGGAGGCTGCTTCCCAGTAAGAATCCAGGAGCAAGCTTTGGTGAATCCAG
TGGGCTGAGTGGCTCTATGGATGTGGTTGTTTGGATGTGGTAGGGAGTGCTTAGCAGAATGTGTGTGTATCTCTGAGGCTGTCAGGGGGT
GGGTGGGTGTGTGTCTCTGTTGGACCTGTCTCTCCTCAGTCTATTCCTGTCATAGATGTGGGTGTCCCTGGTAGGGAAGTGCCTGTGTGG
TCTGTTTACAGTGCAGAAGGCGGCTCAGCAGTGCAATGGGCTGACAGCCTTGGACCGGGAGTCAGAAGCCTGGGTTCTGGTTGTAGCTCT
GGCCCCTCCCTGTGATCTTCAACAAGCCACTTGCTTTCTCTCGTCTTCAGTTTCCTCAACTAGAAAATGAACAGCAGCTGAAATTATGTT
GAAGATCCTTTTATACCTGAAAGAGTTTCTTCATAGAAATTTCTGTGGTGGGGAGGGGGCAATCTCTGTGTGTCTCAGTATACCTAAAGG
TTGGGGTGGGGCGGAGTTGTGTGTCTCTGTAGAAAGGCGAAGGGGCAGTTCCTATCAGGACTGTGTATGTCTGAGCACATGTGGCTCTGT
TTGGGATTACGTGTTTGTCTGTGAATGTGTGTGTGTGTTGGAGGGTTGTCTATTGTGTGTGGCTGTATAGGGTGTCTGTAGATCAAGATG
TGTATACAGCTGCTTCTGCTATTGCTGGTTTGGGGGAGGGGACTGGAAAGCTGAGACTGAAAATCAAGAGGGAAGAGGTGAGGAAGGCCC
ACCCCTGGGGCTGGGCAGTGTAGACCTGCCACCGTGTGAAGAAAAATGAAAGCACAGATAGCCTAAGACTGCACAGGCCTGTGCCCACAT
ACCTTATAGCACAGGCCCAGGTGGATCATCTCATGCTAACACCCCACATGTGCTGGTGGATCCACTCCCATGGATCCACTCACATGCTGC
AGGCATGCAGTAGACTCACCCACAGCCCACTCTCTGGACACCAATCCTGGGAGGTGGGAGCTGGAATGGGGAGCAATGAGAGGAGGGAGT
GAGACTGTTGGCTTAGGAAGGGTGGTACCTCTCCCTGCATCATACCCAGGAACTGCCAGCTCCAAAATATTGGGGTACAGCTCACCACCC
CCCACTCCGCCAACCCATTCCTACCTCCTCTAGTGCAGGGACCCAAGTTAGATGATGAGAAAATGCCAAACAAAGGGAGGCAAGGACAGA
GAAGGTACCTGCAGGACCCACAAGGCCCATACTGGCCCCCATCTGAACCCACCTCTCCCACCCAGATCAACATCCCCCCAACCCCTGTGC
CCCCATCATCTGGACCCCAGAGCCAGCCCTCCCACTACCACCACCACCACCCCGGGGCTCCTTGGCTCACCTTTCTAGAACATGGGTACC
TCCTCTTTTTGGGGGCTCATTTAGACTGCTGCCTTTGCTGCTGACTTGCAGTGTGACTCGGGCCCATTGTTCAATCTCTGTGGCCCTGAG
ACACCAGGGAAAATCTCCCCCCCCACAGGACATACTAGTTCCCTGGCAGGCAAGGGCTTCCAACTGAGGCAGTGCATGTGTGGCAGAGAG
AGGCAGGAAGCTGGCAGTGGCAGCTTCTGTGTCTAGGGAGGGGTGTGGCTCCCTCCTTCCCTGTCTGGGAGGTTGGAGGGAAGAATCTAG
GCCTTAGCTTGCCCTCCTGCCACCCTTCCCCTTGTAGATACTGCCTTAACACTCCCTCCTCTCTCAGCTGTGGCTGCCACCCAGCCAGGT
TTCTCCGTGCTCACTAATTTATTTCCAGGAAGGTGTGTGGAAGACATGAGCCGTGTATAATATTTTTTTTAACATTTTCATTGCAGTATT

>84297_84297_6_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379087_length(amino acids)=577AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREEKQR
ELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYSSAEINQDLNIQLLKDGY

--------------------------------------------------------------
>84297_84297_7_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379089_length(transcript)=4616nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGGTGAGTCAGTAGCCATGAATTACAAACCATCCCCGCTCCAAGTGAAGCTG
GAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATGGGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTC
ATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGACCAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACG
GACAGCGATGATGACTTTGACATGTCTAGATACTCCTCCTCCGGCTACTCCTCTGCTGAGATCAACCAAGATTTGAACATCCAGCTGCTG
AAGGACGGCTACCGGTTAGATGAGATCCCCGACGACGAGGACCTAGACCTCATCCCCCCCAAGTCCGTGAACCCCACGTGCATGTGCTGC
CAGGCCACGTCCTCCACCGCCTGCCACATTCAGTAGCGGGCGGGGCCACTGCGGTCGCCGGGGCGGGGCCGCCAAGGGCCGGGTAGGACG
GGCAGAGGCCGACCCCTTCCCAGCTCGTCTGCCTGCCCCCGGCCCCGCGCCCCTACAGCCGCCAACCTCGTATAACAGTCATTGCTTCCT
CCTATGGTAGGACGTGTACCTCTGTGTGTTCATGGAGCTGGAGAAACCAAAACTGGGTCTCTCTCCACCCGGGAGCTGAGGAGGGGTGGG
GGCCGTTTGTTCAGTTACCTGGGGGAACCTCACCCAGCACCCTGCCCCGCTTCCCAGGGCTGGCCAAGAGAGAAGACTGGACGGCAGGGA
GGTCAACATTAACGAGTGGGGGGATCACAAAGCCAGGGGCTTGGCCCCACCCCAGCGAAGCCATGAACTCCCAAGCCCCGGCCTCAGCCT
AACCAGGAAAGGGGCTCGGAGGGAGAAAGGCCCAGGGCAGTGGGGACGGGTCCCAGCACCTCGGAGCCCCCTTCACACGCCCCCTACCGG
CCCATGTTTCTATTTGCATTTCCCCCTCCTCAGATGGGAAGCCTGGCAAAGCTGCCCAACCGGGTAGTGCCCCTCACCCATCGGATCACT
GCCTTCTTCCTCCTCTTGCCCCATTCACCCGCTTCCTTGCACTCTGGGAGTGGGGCAGGGTAAGGTGGGCCTTACAGACAGGCTGAGGTT
TGGGTGGTGTGATCTGTCCTAATTGGCCCCTCACCAATGCATCTATCTGTCTGCCACCAGCCCACCCCACCCTGCCCCCACCCTCACCCA
CGCTTCTGCTCATTGGTCTCAATCCCAGCCTGGAAGCAGGGAGTAAGGCTGGACTCCAATGGCCCATTCCCCTCACCCCAGCCCAAGACG
TGGGAGGCTGCTTCCCAGTAAGAATCCAGGAGCAAGCTTTGGTGAATCCAGTGGGCTGAGTGGCTCTATGGATGTGGTTGTTTGGATGTG
GTAGGGAGTGCTTAGCAGAATGTGTGTGTATCTCTGAGGCTGTCAGGGGGTGGGTGGGTGTGTGTCTCTGTTGGACCTGTCTCTCCTCAG
TCTATTCCTGTCATAGATGTGGGTGTCCCTGGTAGGGAAGTGCCTGTGTGGTCTGTTTACAGTGCAGAAGGCGGCTCAGCAGTGCAATGG
GCTGACAGCCTTGGACCGGGAGTCAGAAGCCTGGGTTCTGGTTGTAGCTCTGGCCCCTCCCTGTGATCTTCAACAAGCCACTTGCTTTCT
CTCGTCTTCAGTTTCCTCAACTAGAAAATGAACAGCAGCTGAAATTATGTTGAAGATCCTTTTATACCTGAAAGAGTTTCTTCATAGAAA
TTTCTGTGGTGGGGAGGGGGCAATCTCTGTGTGTCTCAGTATACCTAAAGGTTGGGGTGGGGCGGAGTTGTGTGTCTCTGTAGAAAGGCG
AAGGGGCAGTTCCTATCAGGACTGTGTATGTCTGAGCACATGTGGCTCTGTTTGGGATTACGTGTTTGTCTGTGAATGTGTGTGTGTGTT
GGAGGGTTGTCTATTGTGTGTGGCTGTATAGGGTGTCTGTAGATCAAGATGTGTATACAGCTGCTTCTGCTATTGCTGGTTTGGGGGAGG
GGACTGGAAAGCTGAGACTGAAAATCAAGAGGGAAGAGGTGAGGAAGGCCCACCCCTGGGGCTGGGCAGTGTAGACCTGCCACCGTGTGA
AGAAAAATGAAAGCACAGATAGCCTAAGACTGCACAGGCCTGTGCCCACATACCTTATAGCACAGGCCCAGGTGGATCATCTCATGCTAA
CACCCCACATGTGCTGGTGGATCCACTCCCATGGATCCACTCACATGCTGCAGGCATGCAGTAGACTCACCCACAGCCCACTCTCTGGAC
ACCAATCCTGGGAGGTGGGAGCTGGAATGGGGAGCAATGAGAGGAGGGAGTGAGACTGTTGGCTTAGGAAGGGTGGTACCTCTCCCTGCA
TCATACCCAGGAACTGCCAGCTCCAAAATATTGGGGTACAGCTCACCACCCCCCACTCCGCCAACCCATTCCTACCTCCTCTAGTGCAGG
GACCCAAGTTAGATGATGAGAAAATGCCAAACAAAGGGAGGCAAGGACAGAGAAGGTACCTGCAGGACCCACAAGGCCCATACTGGCCCC
CATCTGAACCCACCTCTCCCACCCAGATCAACATCCCCCCAACCCCTGTGCCCCCATCATCTGGACCCCAGAGCCAGCCCTCCCACTACC
ACCACCACCACCCCGGGGCTCCTTGGCTCACCTTTCTAGAACATGGGTACCTCCTCTTTTTGGGGGCTCATTTAGACTGCTGCCTTTGCT
GCTGACTTGCAGTGTGACTCGGGCCCATTGTTCAATCTCTGTGGCCCTGAGACACCAGGGAAAATCTCCCCCCCCACAGGACATACTAGT
TCCCTGGCAGGCAAGGGCTTCCAACTGAGGCAGTGCATGTGTGGCAGAGAGAGGCAGGAAGCTGGCAGTGGCAGCTTCTGTGTCTAGGGA
GGGGTGTGGCTCCCTCCTTCCCTGTCTGGGAGGTTGGAGGGAAGAATCTAGGCCTTAGCTTGCCCTCCTGCCACCCTTCCCCTTGTAGAT
ACTGCCTTAACACTCCCTCCTCTCTCAGCTGTGGCTGCCACCCAGCCAGGTTTCTCCGTGCTCACTAATTTATTTCCAGGAAGGTGTGTG
GAAGACATGAGCCGTGTATAATATTTTTTTTAACATTTTCATTGCAGTATTGACCATCATCCTTGGTTGTGTATCGTGTAACACAAATAA

>84297_84297_7_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000379089_length(amino acids)=594AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREGESV
AMNYKPSPLQVKLEKQRELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYS

--------------------------------------------------------------
>84297_84297_8_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000445726_length(transcript)=4618nt_BP=1341nt
CGCGACTGGCCTTGAGGGAGAGCTGGGGCCTGCTCCCGGAGAGATACGGCTATGTCGATCGAAATCGAATCTTCGGATGTGATCCGCCTT
ATTATGCAGTACTTGAAGGAGAACAGTTTACATCGGGCGTTAGCCACCTTGCAGGAGGAGACTACTGTGTCTCTGAATACTGTGGACAGC
ATTGAGAGTTTTGTGGCTGACATTAACAGTGGCCATTGGGATACTGTGTTGCAGGCTATACAGTCTCTGAAATTGCCAGACAAAACCCTC
ATTGACCTCTATGAACAGGTTGTTCTGGAATTGATAGAGCTCCGTGAATTGGGTGCTGCCAGGTCACTTTTGAGACAGACTGATCCCATG
ATCATGTTAAAACAAACACAGCCAGAGCGATATATTCATCTGGAGAACCTTTTGGCCAGGTCTTACTTTGATCCTCGTGAGGCATACCCA
GATGGAAGTAGCAAAGAAAAGAGAAGAGCAGCAATTGCCCAGGCCTTAGCTGGCGAAGTCAGTGTGGTGCCTCCATCTCGTCTCATGGCA
TTGCTGGGACAGGCACTGAAGTGGCAGCAGCATCAGGGATTGCTTCCTCCTGGTATGACCATAGATTTGTTTCGAGGCAAGGCAGCTGTC
AAAGATGTGGAAGAAGAAAAGTTTCCTACACAACTGAGCAGGCATATTAAGTTTGGTCAGAAATCACATGTGGAGTGTGCTCGATTTTCT
CCAGATGGTCAGTATTTGGTCACTGGGTCTGTTGATGGATTCATTGAAGTATGGAACTTTACTACTGGAAAAATCAGAAAGGATCTTAAG
TACCAGGCCCAAGATAACTTTATGATGATGGATGATGCTGTCCTCTGCATGTGTTTCAGCAGAGATACAGAAATGTTAGCAACTGGGGCC
CAAGATGGAAAAATCAAGGTGTGGAAGATTCAGAGTGGACAATGTTTAAGGAGATTTGAGAGGGCACACAGTAAGGGTGTCACCTGTCTA
AGCTTTTCTAAGGATAGCAGTCAGATCCTTAGTGCTTCTTTTGACCAGACAATTAGAATTCATGGTTTAAAATCTGGGAAAACCCTGAAG
GAATTTCGTGGCCATTCCTCCTTTGTTAACGAAGCAACATTTACACAAGATGGACATTACATTATTAGTGCATCCTCTGATGGCACTGTA
AAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTG
ATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGGACCCAGCC
GCCGCCTCCATCTCTGACGGAGACTGTGACGCCCGGGAGGGTGAGTCAGTAGCCATGAATTACAAACCATCCCCGCTCCAAGTGAAGCTG
GAGAAGCAGCGGGAGCTGGCCCGGAAGGGCTCCCTGAAGAATGGCAGCATGGGTAGCCCTGTCAACCAGCAACCCAAGAAGAACAATGTC
ATGGCCCGAACAAGGCTGGTCGTCCCCAATAAAGGCTACTCCTCACTTGACCAGAGCCCTGATGAGAAGCCACTGGTAGCCCTTGACACG
GACAGCGATGATGACTTTGACATGTCTAGATACTCCTCCTCCGGCTACTCCTCTGCTGAGCAGATCAACCAAGATTTGAACATCCAGCTG
CTGAAGGACGGCTACCGGTTAGATGAGATCCCCGACGACGAGGACCTAGACCTCATCCCCCCCAAGTCCGTGAACCCCACGTGCATGTGC
TGCCAGGCCACGTCCTCCACCGCCTGCCACATTCAGTAGCGGGCGGGGCCACTGCGGTCGCCGGGGCGGGGCCGCCAAGGGCCGGGTAGG
ACGGGCAGAGGCCGACCCCTTCCCAGCTCGTCTGCCTGCCCCCGGCCCCGCGCCCCTACAGCCGCCAACCTCGTATAACAGTCATTGCTT
CCTCCTATGGTAGGACGTGTACCTCTGTGTGTTCATGGAGCTGGAGAAACCAAAACTGGGTCTCTCTCCACCCGGGAGCTGAGGAGGGGT
GGGGGCCGTTTGTTCAGTTACCTGGGGGAACCTCACCCAGCACCCTGCCCCGCTTCCCAGGGCTGGCCAAGAGAGAAGACTGGACGGCAG
GGAGGTCAACATTAACGAGTGGGGGGATCACAAAGCCAGGGGCTTGGCCCCACCCCAGCGAAGCCATGAACTCCCAAGCCCCGGCCTCAG
CCTAACCAGGAAAGGGGCTCGGAGGGAGAAAGGCCCAGGGCAGTGGGGACGGGTCCCAGCACCTCGGAGCCCCCTTCACACGCCCCCTAC
CGGCCCATGTTTCTATTTGCATTTCCCCCTCCTCAGATGGGAAGCCTGGCAAAGCTGCCCAACCGGGTAGTGCCCCTCACCCATCGGATC
ACTGCCTTCTTCCTCCTCTTGCCCCATTCACCCGCTTCCTTGCACTCTGGGAGTGGGGCAGGGTAAGGTGGGCCTTACAGACAGGCTGAG
GTTTGGGTGGTGTGATCTGTCCTAATTGGCCCCTCACCAATGCATCTATCTGTCTGCCACCAGCCCACCCCACCCTGCCCCCACCCTCAC
CCACGCTTCTGCTCATTGGTCTCAATCCCAGCCTGGAAGCAGGGAGTAAGGCTGGACTCCAATGGCCCATTCCCCTCACCCCAGCCCAAG
ACGTGGGAGGCTGCTTCCCAGTAAGAATCCAGGAGCAAGCTTTGGTGAATCCAGTGGGCTGAGTGGCTCTATGGATGTGGTTGTTTGGAT
GTGGTAGGGAGTGCTTAGCAGAATGTGTGTGTATCTCTGAGGCTGTCAGGGGGTGGGTGGGTGTGTGTCTCTGTTGGACCTGTCTCTCCT
CAGTCTATTCCTGTCATAGATGTGGGTGTCCCTGGTAGGGAAGTGCCTGTGTGGTCTGTTTACAGTGCAGAAGGCGGCTCAGCAGTGCAA
TGGGCTGACAGCCTTGGACCGGGAGTCAGAAGCCTGGGTTCTGGTTGTAGCTCTGGCCCCTCCCTGTGATCTTCAACAAGCCACTTGCTT
TCTCTCGTCTTCAGTTTCCTCAACTAGAAAATGAACAGCAGCTGAAATTATGTTGAAGATCCTTTTATACCTGAAAGAGTTTCTTCATAG
AAATTTCTGTGGTGGGGAGGGGGCAATCTCTGTGTGTCTCAGTATACCTAAAGGTTGGGGTGGGGCGGAGTTGTGTGTCTCTGTAGAAAG
GCGAAGGGGCAGTTCCTATCAGGACTGTGTATGTCTGAGCACATGTGGCTCTGTTTGGGATTACGTGTTTGTCTGTGAATGTGTGTGTGT
GTTGGAGGGTTGTCTATTGTGTGTGGCTGTATAGGGTGTCTGTAGATCAAGATGTGTATACAGCTGCTTCTGCTATTGCTGGTTTGGGGG
AGGGGACTGGAAAGCTGAGACTGAAAATCAAGAGGGAAGAGGTGAGGAAGGCCCACCCCTGGGGCTGGGCAGTGTAGACCTGCCACCGTG
TGAAGAAAAATGAAAGCACAGATAGCCTAAGACTGCACAGGCCTGTGCCCACATACCTTATAGCACAGGCCCAGGTGGATCATCTCATGC
TAACACCCCACATGTGCTGGTGGATCCACTCCCATGGATCCACTCACATGCTGCAGGCATGCAGTAGACTCACCCACAGCCCACTCTCTG
GACACCAATCCTGGGAGGTGGGAGCTGGAATGGGGAGCAATGAGAGGAGGGAGTGAGACTGTTGGCTTAGGAAGGGTGGTACCTCTCCCT
GCATCATACCCAGGAACTGCCAGCTCCAAAATATTGGGGTACAGCTCACCACCCCCCACTCCGCCAACCCATTCCTACCTCCTCTAGTGC
AGGGACCCAAGTTAGATGATGAGAAAATGCCAAACAAAGGGAGGCAAGGACAGAGAAGGTACCTGCAGGACCCACAAGGCCCATACTGGC
CCCCATCTGAACCCACCTCTCCCACCCAGATCAACATCCCCCCAACCCCTGTGCCCCCATCATCTGGACCCCAGAGCCAGCCCTCCCACT
ACCACCACCACCACCCCGGGGCTCCTTGGCTCACCTTTCTAGAACATGGGTACCTCCTCTTTTTGGGGGCTCATTTAGACTGCTGCCTTT
GCTGCTGACTTGCAGTGTGACTCGGGCCCATTGTTCAATCTCTGTGGCCCTGAGACACCAGGGAAAATCTCCCCCCCCACAGGACATACT
AGTTCCCTGGCAGGCAAGGGCTTCCAACTGAGGCAGTGCATGTGTGGCAGAGAGAGGCAGGAAGCTGGCAGTGGCAGCTTCTGTGTCTAG
GGAGGGGTGTGGCTCCCTCCTTCCCTGTCTGGGAGGTTGGAGGGAAGAATCTAGGCCTTAGCTTGCCCTCCTGCCACCCTTCCCCTTGTA
GATACTGCCTTAACACTCCCTCCTCTCTCAGCTGTGGCTGCCACCCAGCCAGGTTTCTCCGTGCTCACTAATTTATTTCCAGGAAGGTGT
GTGGAAGACATGAGCCGTGTATAATATTTTTTTTAACATTTTCATTGCAGTATTGACCATCATCCTTGGTTGTGTATCGTGTAACACAAA

>84297_84297_8_SMU1-FAM219A_SMU1_chr9_33053121_ENST00000397149_FAM219A_chr9_34405962_ENST00000445726_length(amino acids)=595AA_BP=429
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELREL
GAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM
CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQDPAAASISDGDCDAREGESV
AMNYKPSPLQVKLEKQRELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQSPDEKPLVALDTDSDDDFDMSRYSSSGYS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SMU1-FAM219A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SMU1-FAM219A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SMU1-FAM219A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source