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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMURF1-CDK14 (FusionGDB2 ID:84307)

Fusion Gene Summary for SMURF1-CDK14

check button Fusion gene summary
Fusion gene informationFusion gene name: SMURF1-CDK14
Fusion gene ID: 84307
HgeneTgene
Gene symbol

SMURF1

CDK14

Gene ID

57154

5218

Gene nameSMAD specific E3 ubiquitin protein ligase 1cyclin dependent kinase 14
Synonyms-PFTAIRE1|PFTK1
Cytomap

7q22.1

7q21.13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase SMURF1E3 ubiquitin ligase SMURF1HECT-type E3 ubiquitin transferase SMURF1Smad ubiquitination regulatory factor 1Smad-specific E3 ubiquitin ligase 1hSMURF1cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1
Modification date2020031320200313
UniProtAcc.

O94921

Ensembl transtripts involved in fusion geneENST00000361125, ENST00000361368, 
ENST00000480055, 		ENST00000496279, 
ENST00000265741, ENST00000380050, 
ENST00000406263, ENST00000436577, 
Fusion gene scores* DoF score19 X 8 X 12=182422 X 24 X 12=6336
# samples 2432
** MAII scorelog2(24/1824*10)=-2.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/6336*10)=-4.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMURF1 [Title/Abstract] AND CDK14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMURF1(98658222)-CDK14(90675212), # samples:3
Anticipated loss of major functional domain due to fusion event.SMURF1-CDK14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SMURF1-CDK14 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SMURF1-CDK14 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMURF1

GO:0000209

protein polyubiquitination

19937093

HgeneSMURF1

GO:0006511

ubiquitin-dependent protein catabolic process

10458166|12151385|19937093

HgeneSMURF1

GO:0006611

protein export from nucleus

11278251

HgeneSMURF1

GO:0016567

protein ubiquitination

11278251

HgeneSMURF1

GO:0030154

cell differentiation

10458166

HgeneSMURF1

GO:0030509

BMP signaling pathway

21572392

HgeneSMURF1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

11278251|12151385

HgeneSMURF1

GO:0030514

negative regulation of BMP signaling pathway

27214554

HgeneSMURF1

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

11278251|12151385

HgeneSMURF1

GO:0032801

receptor catabolic process

12151385

HgeneSMURF1

GO:0034394

protein localization to cell surface

12151385

HgeneSMURF1

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

11278251

HgeneSMURF1

GO:1903861

positive regulation of dendrite extension

23999003

TgeneCDK14

GO:0000086

G2/M transition of mitotic cell cycle

20059949

TgeneCDK14

GO:0060828

regulation of canonical Wnt signaling pathway

20059949


check buttonFusion gene breakpoints across SMURF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDK14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8484-01ASMURF1chr7

98658222

-CDK14chr7

90675212

+
ChimerDB4STADTCGA-BR-8484SMURF1chr7

98658221

-CDK14chr7

90675211

+
ChimerDB4STADTCGA-BR-8484SMURF1chr7

98658221

-CDK14chr7

90741856

+
ChimerDB4STADTCGA-BR-8484SMURF1chr7

98659421

-CDK14chr7

90675211

+


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Fusion Gene ORF analysis for SMURF1-CDK14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361125ENST00000496279SMURF1chr7

98658222

-CDK14chr7

90675212

+
5CDS-intronENST00000361125ENST00000496279SMURF1chr7

98658221

-CDK14chr7

90675211

+
5CDS-intronENST00000361125ENST00000496279SMURF1chr7

98658221

-CDK14chr7

90741856

+
5CDS-intronENST00000361125ENST00000496279SMURF1chr7

98659421

-CDK14chr7

90675211

+
5CDS-intronENST00000361368ENST00000496279SMURF1chr7

98658222

-CDK14chr7

90675212

+
5CDS-intronENST00000361368ENST00000496279SMURF1chr7

98658221

-CDK14chr7

90675211

+
5CDS-intronENST00000361368ENST00000496279SMURF1chr7

98658221

-CDK14chr7

90741856

+
5CDS-intronENST00000361368ENST00000496279SMURF1chr7

98659421

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000265741SMURF1chr7

98658222

-CDK14chr7

90675212

+
5UTR-3CDSENST00000480055ENST00000265741SMURF1chr7

98658221

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000265741SMURF1chr7

98658221

-CDK14chr7

90741856

+
5UTR-3CDSENST00000480055ENST00000265741SMURF1chr7

98659421

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000380050SMURF1chr7

98658222

-CDK14chr7

90675212

+
5UTR-3CDSENST00000480055ENST00000380050SMURF1chr7

98658221

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000380050SMURF1chr7

98658221

-CDK14chr7

90741856

+
5UTR-3CDSENST00000480055ENST00000380050SMURF1chr7

98659421

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000406263SMURF1chr7

98658222

-CDK14chr7

90675212

+
5UTR-3CDSENST00000480055ENST00000406263SMURF1chr7

98658221

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000406263SMURF1chr7

98658221

-CDK14chr7

90741856

+
5UTR-3CDSENST00000480055ENST00000406263SMURF1chr7

98659421

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000436577SMURF1chr7

98658222

-CDK14chr7

90675212

+
5UTR-3CDSENST00000480055ENST00000436577SMURF1chr7

98658221

-CDK14chr7

90675211

+
5UTR-3CDSENST00000480055ENST00000436577SMURF1chr7

98658221

-CDK14chr7

90741856

+
5UTR-3CDSENST00000480055ENST00000436577SMURF1chr7

98659421

-CDK14chr7

90675211

+
5UTR-intronENST00000480055ENST00000496279SMURF1chr7

98658222

-CDK14chr7

90675212

+
5UTR-intronENST00000480055ENST00000496279SMURF1chr7

98658221

-CDK14chr7

90675211

+
5UTR-intronENST00000480055ENST00000496279SMURF1chr7

98658221

-CDK14chr7

90741856

+
5UTR-intronENST00000480055ENST00000496279SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000265741SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361125ENST00000265741SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000265741SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000380050SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361125ENST00000380050SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000380050SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000406263SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361125ENST00000406263SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000406263SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000436577SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361125ENST00000436577SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361125ENST00000436577SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000265741SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361368ENST00000265741SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000265741SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000380050SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361368ENST00000380050SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000380050SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000406263SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361368ENST00000406263SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000406263SMURF1chr7

98659421

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000436577SMURF1chr7

98658222

-CDK14chr7

90675212

+
Frame-shiftENST00000361368ENST00000436577SMURF1chr7

98658221

-CDK14chr7

90675211

+
Frame-shiftENST00000361368ENST00000436577SMURF1chr7

98659421

-CDK14chr7

90675211

+
In-frameENST00000361125ENST00000265741SMURF1chr7

98658221

-CDK14chr7

90741856

+
In-frameENST00000361125ENST00000380050SMURF1chr7

98658221

-CDK14chr7

90741856

+
In-frameENST00000361125ENST00000406263SMURF1chr7

98658221

-CDK14chr7

90741856

+
In-frameENST00000361125ENST00000436577SMURF1chr7

98658221

-CDK14chr7

90741856

+
In-frameENST00000361368ENST00000265741SMURF1chr7

98658221

-CDK14chr7

90741856

+
In-frameENST00000361368ENST00000380050SMURF1chr7

98658221

-CDK14chr7

90741856

+
In-frameENST00000361368ENST00000406263SMURF1chr7

98658221

-CDK14chr7

90741856

+
In-frameENST00000361368ENST00000436577SMURF1chr7

98658221

-CDK14chr7

90741856

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361368SMURF1chr798658221-ENST00000380050CDK14chr790741856+415244220697225
ENST00000361368SMURF1chr798658221-ENST00000265741CDK14chr790741856+415144220697225
ENST00000361368SMURF1chr798658221-ENST00000406263CDK14chr790741856+414744220697225
ENST00000361368SMURF1chr798658221-ENST00000436577CDK14chr790741856+92444220697225
ENST00000361125SMURF1chr798658221-ENST00000380050CDK14chr790741856+4233523101778225
ENST00000361125SMURF1chr798658221-ENST00000265741CDK14chr790741856+4232523101778225
ENST00000361125SMURF1chr798658221-ENST00000406263CDK14chr790741856+4228523101778225
ENST00000361125SMURF1chr798658221-ENST00000436577CDK14chr790741856+1005523101778225

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361368ENST00000380050SMURF1chr798658221-CDK14chr790741856+0.0046270980.99537295
ENST00000361368ENST00000265741SMURF1chr798658221-CDK14chr790741856+0.005862940.99413705
ENST00000361368ENST00000406263SMURF1chr798658221-CDK14chr790741856+0.0062888860.9937111
ENST00000361368ENST00000436577SMURF1chr798658221-CDK14chr790741856+0.0198685420.98013145
ENST00000361125ENST00000380050SMURF1chr798658221-CDK14chr790741856+0.004793340.99520665
ENST00000361125ENST00000265741SMURF1chr798658221-CDK14chr790741856+0.0060739050.9939261
ENST00000361125ENST00000406263SMURF1chr798658221-CDK14chr790741856+0.0065056840.99349433
ENST00000361125ENST00000436577SMURF1chr798658221-CDK14chr790741856+0.0147059690.985294

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Fusion Genomic Features for SMURF1-CDK14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMURF1chr798659421-CDK14chr790675211+0.0046296310.9953703
SMURF1chr798658221-CDK14chr790675211+0.0001714130.9998286
SMURF1chr798658221-CDK14chr790675211+0.0001714130.9998286
SMURF1chr798658221-CDK14chr790741856+3.40E-070.99999964
SMURF1chr798659421-CDK14chr790675211+0.0046296310.9953703
SMURF1chr798658221-CDK14chr790675211+0.0001714130.9998286
SMURF1chr798658221-CDK14chr790675211+0.0001714130.9998286
SMURF1chr798658221-CDK14chr790741856+3.40E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SMURF1-CDK14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:98658222/chr7:90675212)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDK14

O94921

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361125-3191_12067758.0DomainC2
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361125-319234_26767758.0DomainWW 1
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361125-319306_33967758.0DomainWW 2
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361125-319420_75767758.0DomainHECT
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361368-3181_12067732.0DomainC2
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361368-318234_26767732.0DomainWW 1
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361368-318306_33967732.0DomainWW 2
HgeneSMURF1chr7:98658221chr7:90741856ENST00000361368-318420_75767732.0DomainHECT
TgeneCDK14chr7:98658221chr7:90741856ENST000002657411014135_4193661522.6666666666667DomainProtein kinase
TgeneCDK14chr7:98658221chr7:90741856ENST000003800501115135_4193841538.0DomainProtein kinase
TgeneCDK14chr7:98658221chr7:90741856ENST000004062631014135_4193381422.0DomainProtein kinase
TgeneCDK14chr7:98658221chr7:90741856ENST000002657411014141_1493661522.6666666666667Nucleotide bindingATP
TgeneCDK14chr7:98658221chr7:90741856ENST000003800501115141_1493841538.0Nucleotide bindingATP
TgeneCDK14chr7:98658221chr7:90741856ENST000004062631014141_1493381422.0Nucleotide bindingATP


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Fusion Gene Sequence for SMURF1-CDK14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84307_84307_1_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000265741_length(transcript)=4232nt_BP=523nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTGTCGTGGATG
GGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCTATGTGAACC
ATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGTATTTTAGTG
ACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTGGAGAAAGCA
TGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGCACACAGGAT
TAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTCTTTCGCTCC
CTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCATTTGGATAC
CTTGTGATTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCATGTATTCTTTTCAGTCTTTTGTGTTTGATTTTGTT
TGATTTCCCTCTGCAGCACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAATACATTAAGACAACACATTTGGTGT
TCACACTTCTTCAGTAATGTCTGAACTTGAAAGCCACAGAGTGGCATAAAACAATGTGTGTTTTCTTTGAGAGCAGTGCACATTTTGCAA
CCACTAGGAAGGAAATTTTCTGCTAAAGCAAACCCCTGTTCTCTGACTTGACAACTTGGCCCCGGACTGTGGGGCCCCACCTGTTGCTTA
CCTTTTGAGGTAATTTTGCAAATGTGGTTTTTTTACTTGGAAATAACTGCACATTTATATATAGGATATTGGACTCTGCTTAGCATTTTC
AAGCCACATAGCATGACTGTTTTTTGAATAGGTTGGAATTGAAAAAACAATTATCAAACGTTAAGAACAAAGACAGGGATAAATTGCTTA
CATTTCAACCTCTGGAGATTGAGGTAACTTTTTGTGTCTGGGTCTTGTCAACATCTAATTTTTTTCCATCCATTCTGTTACACTTTGTAT
TTTCTAACTGGAGAAAAGAGTGAGGAACAGAATGTTTTAAATCTGGTGCAAAAGAACTATATCTGCTGGATGAGCCTTGAAAGCAGTCTT
GGCCTGTTAGGGCTTACAAAGTAAATTACAAAGTGATCCAGTTCAAAGTTTGCTTAGTTACAACAAAGCACCTTTAAAAAAAATACATTT
TAAAAAAACATTCCAAGCCAATTGGAAGACATCATTGGGTTCTTACTTTAAGACATCTCCTGGAATAACTGTTCAAATGCAGGTTTTAGA
AACAATGCAGGAATCTTGCTTTAAAGATGAAAAAGGGAATGGGCCAGCTTCCCTTACTCAAGGAGTTGAGGGACCTTGGAGGATGAAGGC
GAGTATGTGACACTGGAGAAAAGTGGACCAGGCATGTCTTTTGCTTTGATCTGGAGGGAGGGCTGCCTGATGCAGGCCGGCTCCCAGTGG
GGCAGGCCTCGCTGCAGAATGCCCAGTAGTACTGCGGCCAAGGGGACAGTTAGGAGACTTCATCTAAAGCATGAAACCTAGCTCCTCTAC
ACACAAATTCCTATGGAAATACCTTTGTGTACAGTGTCTTACATTTTCCTATTAGTCAGAAAGAAGGAGAGAATGAGTGAGTGCTTGAAA
TGTGTCATACTGTTTTAGGATCAAGACTAGGAATTAGGAGCCAGGTTGACAAGGACTTTTTCTGAGAGTTGGGTGAGGGTAAAGCTTTTC
TATAATCAAGCTCAATACACCAAGGAAACTGGATCCAGAATTCCTAAACTTTAAAATGGTACTGTCTGCGGAGTGGAGTATGGATGGTTA
TGTCAAAGTCATAGTTCATCCTATCCAGATGTAGCATTCATGGTAAACTTTTAAGTGCTAAGCAAGGAATTATTTACTGATTGGTTTTAA
AGAGAGCAGAAAACACCCAAGTGTAGAATGTCTACTGTTTGCTACCTAGAAATCTTTTCCATTCCTCTTTCATACATTCCAACCCACTGG
AAGTCTTTAGAGGTATTTTGATTTAAAGTATACTTAAATTAGGATTTCTTAAAGAAAACATAGGGAGAAAACTTTACATGCAATTAAAAA
TGGACTTTCCTGTGATTTGTTTTTAATCATTCATTTGGAGAAGAGGCATGACCTTTGTATTTCACTAAGTTTAAAGCAAGAGCAACTGAT
GATTAAATGTTGCTTTTTAATAAGGTTTTTAACTTGAAAATTTGAAAATATTTAATGTTGAAAGACTTCAATTAGGGCTATTAGAGTTAT
ATCTCCCTGTCGTAGGCAGCTTCTTCGGAGAAGTGAAATATAACATTACTCAGTGGACGGAGAAATCTGTTTTGTTACAGAGACATGCCT
CTCAGAAGGTCAGGAGGTTTTGAGTACCTATCCTTGCCACCCATACAGGAAATCCAAAGTTTGGTGTCTCTCTCTCTCTGTCTCTTTCTT
TCTCTTTCTCCCCCCAAACCCCTCTCACTCCCTCCCTCCCTCTCTCCTTCCCCTATTTGCAATCATATTCTCCCTCTGCTTCTTTTCTCT
TCTGCCCTCCTTGTGGGCAGTCATGAAAATCAATTCAGACTGTGTTGATTAGCAGATTTATTATTCTATTGAGAAAGCACTGGAATGTTT
TGTGAGATTATTTTTATATGAAGGAATAGCCTGAACTCAAACAGATGGTAAGAATAGTACAAACACCTTAGCACATCACTGCACACACAG
TATTCTGAAAGGAGATTTGACACTTAATTCCCATTTTCTTAAAATAACAGTTTTGTTGACTTAAAAATATGAGATACATAGGATGTGAAA
AAAAATGTTTGCAGTACTCAGCAAAAAATAGGGTACATAAAGCAGGGTGGCTGTCCATCCACTGATTCTGGGGTGAGAAGCGATTTCTAC
CTCGCAAGAGTGACTAGAAAGTTTCTAGGAGCACCTCCAGGCTTGCAAAGAAAGTGAGGCCTCTTGGTATCCTTTCCTCAGTGTGTATAT
GACAGCCAGTATAATCAATACCCTAGGTTATGCGTCTATATGATACTCATCTGTGAATATTATTGGTTTTGTAATCTTTGTTATATAAGA
GGATGTTTAGGCTGTATATACTGGGGTAGATTATTGCCTGCCCCTTATACATAGGAATATGCTGCATAATTGCGCATAACTTCCATCTCC
CTTACTGGCTTGTAGGCAGAGGAAACTGTATATGTTACTGCCTTGTACTTTTCTCATACACCAAAAACACACCAAAAAAATCAATAAAAT
AAGCAATCTTCTATTCTCATTCCTTTTCCCACAGCAGCATATTTTAGAGGCACATACAAAACCTACATTCTCTAGTTGGGAGTGGATTTT
TAAAGTTTTCCTTTTATCTTTTATTTTTTTTTGTATGATGCACTGAGATGTGTACTTTCTAACAGGGGATTGGTACCTAAGAAATGTGGT
AGCATTATTCAGAAAACTATTATACTTTCAAATGACACATAGTAAGGAGAATGGAATAATACATGTTGCATATTTGTTACCAGTTGTAAT
TTGTCTGTATTATGAAAGATGTAATGGTTTGTCAGCTGTCACTGTTGTTTTCTTGTAACATGATATGGAATAAAGTATAGCAGAATCTCC

>84307_84307_1_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000265741_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------
>84307_84307_2_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000380050_length(transcript)=4233nt_BP=523nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTGTCGTGGATG
GGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCTATGTGAACC
ATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGTATTTTAGTG
ACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTGGAGAAAGCA
TGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGCACACAGGAT
TAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTCTTTCGCTCC
CTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCATTTGGATAC
CTTGTGATTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCATGTATTCTTTTCAGTCTTTTGTGTTTGATTTTGTT
TGATTTCCCTCTGCAGCACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAATACATTAAGACAACACATTTGGTGT
TCACACTTCTTCAGTAATGTCTGAACTTGAAAGCCACAGAGTGGCATAAAACAATGTGTGTTTTCTTTGAGAGCAGTGCACATTTTGCAA
CCACTAGGAAGGAAATTTTCTGCTAAAGCAAACCCCTGTTCTCTGACTTGACAACTTGGCCCCGGACTGTGGGGCCCCACCTGTTGCTTA
CCTTTTGAGGTAATTTTGCAAATGTGGTTTTTTTACTTGGAAATAACTGCACATTTATATATAGGATATTGGACTCTGCTTAGCATTTTC
AAGCCACATAGCATGACTGTTTTTTGAATAGGTTGGAATTGAAAAAACAATTATCAAACGTTAAGAACAAAGACAGGGATAAATTGCTTA
CATTTCAACCTCTGGAGATTGAGGTAACTTTTTGTGTCTGGGTCTTGTCAACATCTAATTTTTTTCCATCCATTCTGTTACACTTTGTAT
TTTCTAACTGGAGAAAAGAGTGAGGAACAGAATGTTTTAAATCTGGTGCAAAAGAACTATATCTGCTGGATGAGCCTTGAAAGCAGTCTT
GGCCTGTTAGGGCTTACAAAGTAAATTACAAAGTGATCCAGTTCAAAGTTTGCTTAGTTACAACAAAGCACCTTTAAAAAAAATACATTT
TAAAAAAACATTCCAAGCCAATTGGAAGACATCATTGGGTTCTTACTTTAAGACATCTCCTGGAATAACTGTTCAAATGCAGGTTTTAGA
AACAATGCAGGAATCTTGCTTTAAAGATGAAAAAGGGAATGGGCCAGCTTCCCTTACTCAAGGAGTTGAGGGACCTTGGAGGATGAAGGC
GAGTATGTGACACTGGAGAAAAGTGGACCAGGCATGTCTTTTGCTTTGATCTGGAGGGAGGGCTGCCTGATGCAGGCCGGCTCCCAGTGG
GGCAGGCCTCGCTGCAGAATGCCCAGTAGTACTGCGGCCAAGGGGACAGTTAGGAGACTTCATCTAAAGCATGAAACCTAGCTCCTCTAC
ACACAAATTCCTATGGAAATACCTTTGTGTACAGTGTCTTACATTTTCCTATTAGTCAGAAAGAAGGAGAGAATGAGTGAGTGCTTGAAA
TGTGTCATACTGTTTTAGGATCAAGACTAGGAATTAGGAGCCAGGTTGACAAGGACTTTTTCTGAGAGTTGGGTGAGGGTAAAGCTTTTC
TATAATCAAGCTCAATACACCAAGGAAACTGGATCCAGAATTCCTAAACTTTAAAATGGTACTGTCTGCGGAGTGGAGTATGGATGGTTA
TGTCAAAGTCATAGTTCATCCTATCCAGATGTAGCATTCATGGTAAACTTTTAAGTGCTAAGCAAGGAATTATTTACTGATTGGTTTTAA
AGAGAGCAGAAAACACCCAAGTGTAGAATGTCTACTGTTTGCTACCTAGAAATCTTTTCCATTCCTCTTTCATACATTCCAACCCACTGG
AAGTCTTTAGAGGTATTTTGATTTAAAGTATACTTAAATTAGGATTTCTTAAAGAAAACATAGGGAGAAAACTTTACATGCAATTAAAAA
TGGACTTTCCTGTGATTTGTTTTTAATCATTCATTTGGAGAAGAGGCATGACCTTTGTATTTCACTAAGTTTAAAGCAAGAGCAACTGAT
GATTAAATGTTGCTTTTTAATAAGGTTTTTAACTTGAAAATTTGAAAATATTTAATGTTGAAAGACTTCAATTAGGGCTATTAGAGTTAT
ATCTCCCTGTCGTAGGCAGCTTCTTCGGAGAAGTGAAATATAACATTACTCAGTGGACGGAGAAATCTGTTTTGTTACAGAGACATGCCT
CTCAGAAGGTCAGGAGGTTTTGAGTACCTATCCTTGCCACCCATACAGGAAATCCAAAGTTTGGTGTCTCTCTCTCTCTGTCTCTTTCTT
TCTCTTTCTCCCCCCAAACCCCTCTCACTCCCTCCCTCCCTCTCTCCTTCCCCTATTTGCAATCATATTCTCCCTCTGCTTCTTTTCTCT
TCTGCCCTCCTTGTGGGCAGTCATGAAAATCAATTCAGACTGTGTTGATTAGCAGATTTATTATTCTATTGAGAAAGCACTGGAATGTTT
TGTGAGATTATTTTTATATGAAGGAATAGCCTGAACTCAAACAGATGGTAAGAATAGTACAAACACCTTAGCACATCACTGCACACACAG
TATTCTGAAAGGAGATTTGACACTTAATTCCCATTTTCTTAAAATAACAGTTTTGTTGACTTAAAAATATGAGATACATAGGATGTGAAA
AAAAATGTTTGCAGTACTCAGCAAAAAATAGGGTACATAAAGCAGGGTGGCTGTCCATCCACTGATTCTGGGGTGAGAAGCGATTTCTAC
CTCGCAAGAGTGACTAGAAAGTTTCTAGGAGCACCTCCAGGCTTGCAAAGAAAGTGAGGCCTCTTGGTATCCTTTCCTCAGTGTGTATAT
GACAGCCAGTATAATCAATACCCTAGGTTATGCGTCTATATGATACTCATCTGTGAATATTATTGGTTTTGTAATCTTTGTTATATAAGA
GGATGTTTAGGCTGTATATACTGGGGTAGATTATTGCCTGCCCCTTATACATAGGAATATGCTGCATAATTGCGCATAACTTCCATCTCC
CTTACTGGCTTGTAGGCAGAGGAAACTGTATATGTTACTGCCTTGTACTTTTCTCATACACCAAAAACACACCAAAAAAATCAATAAAAT
AAGCAATCTTCTATTCTCATTCCTTTTCCCACAGCAGCATATTTTAGAGGCACATACAAAACCTACATTCTCTAGTTGGGAGTGGATTTT
TAAAGTTTTCCTTTTATCTTTTATTTTTTTTTGTATGATGCACTGAGATGTGTACTTTCTAACAGGGGATTGGTACCTAAGAAATGTGGT
AGCATTATTCAGAAAACTATTATACTTTCAAATGACACATAGTAAGGAGAATGGAATAATACATGTTGCATATTTGTTACCAGTTGTAAT
TTGTCTGTATTATGAAAGATGTAATGGTTTGTCAGCTGTCACTGTTGTTTTCTTGTAACATGATATGGAATAAAGTATAGCAGAATCTCC

>84307_84307_2_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000380050_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------
>84307_84307_3_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000406263_length(transcript)=4228nt_BP=523nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTGTCGTGGATG
GGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCTATGTGAACC
ATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGTATTTTAGTG
ACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTGGAGAAAGCA
TGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGCACACAGGAT
TAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTCTTTCGCTCC
CTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCATTTGGATAC
CTTGTGATTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCATGTATTCTTTTCAGTCTTTTGTGTTTGATTTTGTT
TGATTTCCCTCTGCAGCACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAATACATTAAGACAACACATTTGGTGT
TCACACTTCTTCAGTAATGTCTGAACTTGAAAGCCACAGAGTGGCATAAAACAATGTGTGTTTTCTTTGAGAGCAGTGCACATTTTGCAA
CCACTAGGAAGGAAATTTTCTGCTAAAGCAAACCCCTGTTCTCTGACTTGACAACTTGGCCCCGGACTGTGGGGCCCCACCTGTTGCTTA
CCTTTTGAGGTAATTTTGCAAATGTGGTTTTTTTACTTGGAAATAACTGCACATTTATATATAGGATATTGGACTCTGCTTAGCATTTTC
AAGCCACATAGCATGACTGTTTTTTGAATAGGTTGGAATTGAAAAAACAATTATCAAACGTTAAGAACAAAGACAGGGATAAATTGCTTA
CATTTCAACCTCTGGAGATTGAGGTAACTTTTTGTGTCTGGGTCTTGTCAACATCTAATTTTTTTCCATCCATTCTGTTACACTTTGTAT
TTTCTAACTGGAGAAAAGAGTGAGGAACAGAATGTTTTAAATCTGGTGCAAAAGAACTATATCTGCTGGATGAGCCTTGAAAGCAGTCTT
GGCCTGTTAGGGCTTACAAAGTAAATTACAAAGTGATCCAGTTCAAAGTTTGCTTAGTTACAACAAAGCACCTTTAAAAAAAATACATTT
TAAAAAAACATTCCAAGCCAATTGGAAGACATCATTGGGTTCTTACTTTAAGACATCTCCTGGAATAACTGTTCAAATGCAGGTTTTAGA
AACAATGCAGGAATCTTGCTTTAAAGATGAAAAAGGGAATGGGCCAGCTTCCCTTACTCAAGGAGTTGAGGGACCTTGGAGGATGAAGGC
GAGTATGTGACACTGGAGAAAAGTGGACCAGGCATGTCTTTTGCTTTGATCTGGAGGGAGGGCTGCCTGATGCAGGCCGGCTCCCAGTGG
GGCAGGCCTCGCTGCAGAATGCCCAGTAGTACTGCGGCCAAGGGGACAGTTAGGAGACTTCATCTAAAGCATGAAACCTAGCTCCTCTAC
ACACAAATTCCTATGGAAATACCTTTGTGTACAGTGTCTTACATTTTCCTATTAGTCAGAAAGAAGGAGAGAATGAGTGAGTGCTTGAAA
TGTGTCATACTGTTTTAGGATCAAGACTAGGAATTAGGAGCCAGGTTGACAAGGACTTTTTCTGAGAGTTGGGTGAGGGTAAAGCTTTTC
TATAATCAAGCTCAATACACCAAGGAAACTGGATCCAGAATTCCTAAACTTTAAAATGGTACTGTCTGCGGAGTGGAGTATGGATGGTTA
TGTCAAAGTCATAGTTCATCCTATCCAGATGTAGCATTCATGGTAAACTTTTAAGTGCTAAGCAAGGAATTATTTACTGATTGGTTTTAA
AGAGAGCAGAAAACACCCAAGTGTAGAATGTCTACTGTTTGCTACCTAGAAATCTTTTCCATTCCTCTTTCATACATTCCAACCCACTGG
AAGTCTTTAGAGGTATTTTGATTTAAAGTATACTTAAATTAGGATTTCTTAAAGAAAACATAGGGAGAAAACTTTACATGCAATTAAAAA
TGGACTTTCCTGTGATTTGTTTTTAATCATTCATTTGGAGAAGAGGCATGACCTTTGTATTTCACTAAGTTTAAAGCAAGAGCAACTGAT
GATTAAATGTTGCTTTTTAATAAGGTTTTTAACTTGAAAATTTGAAAATATTTAATGTTGAAAGACTTCAATTAGGGCTATTAGAGTTAT
ATCTCCCTGTCGTAGGCAGCTTCTTCGGAGAAGTGAAATATAACATTACTCAGTGGACGGAGAAATCTGTTTTGTTACAGAGACATGCCT
CTCAGAAGGTCAGGAGGTTTTGAGTACCTATCCTTGCCACCCATACAGGAAATCCAAAGTTTGGTGTCTCTCTCTCTCTGTCTCTTTCTT
TCTCTTTCTCCCCCCAAACCCCTCTCACTCCCTCCCTCCCTCTCTCCTTCCCCTATTTGCAATCATATTCTCCCTCTGCTTCTTTTCTCT
TCTGCCCTCCTTGTGGGCAGTCATGAAAATCAATTCAGACTGTGTTGATTAGCAGATTTATTATTCTATTGAGAAAGCACTGGAATGTTT
TGTGAGATTATTTTTATATGAAGGAATAGCCTGAACTCAAACAGATGGTAAGAATAGTACAAACACCTTAGCACATCACTGCACACACAG
TATTCTGAAAGGAGATTTGACACTTAATTCCCATTTTCTTAAAATAACAGTTTTGTTGACTTAAAAATATGAGATACATAGGATGTGAAA
AAAAATGTTTGCAGTACTCAGCAAAAAATAGGGTACATAAAGCAGGGTGGCTGTCCATCCACTGATTCTGGGGTGAGAAGCGATTTCTAC
CTCGCAAGAGTGACTAGAAAGTTTCTAGGAGCACCTCCAGGCTTGCAAAGAAAGTGAGGCCTCTTGGTATCCTTTCCTCAGTGTGTATAT
GACAGCCAGTATAATCAATACCCTAGGTTATGCGTCTATATGATACTCATCTGTGAATATTATTGGTTTTGTAATCTTTGTTATATAAGA
GGATGTTTAGGCTGTATATACTGGGGTAGATTATTGCCTGCCCCTTATACATAGGAATATGCTGCATAATTGCGCATAACTTCCATCTCC
CTTACTGGCTTGTAGGCAGAGGAAACTGTATATGTTACTGCCTTGTACTTTTCTCATACACCAAAAACACACCAAAAAAATCAATAAAAT
AAGCAATCTTCTATTCTCATTCCTTTTCCCACAGCAGCATATTTTAGAGGCACATACAAAACCTACATTCTCTAGTTGGGAGTGGATTTT
TAAAGTTTTCCTTTTATCTTTTATTTTTTTTTGTATGATGCACTGAGATGTGTACTTTCTAACAGGGGATTGGTACCTAAGAAATGTGGT
AGCATTATTCAGAAAACTATTATACTTTCAAATGACACATAGTAAGGAGAATGGAATAATACATGTTGCATATTTGTTACCAGTTGTAAT

>84307_84307_3_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000406263_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------
>84307_84307_4_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000436577_length(transcript)=1005nt_BP=523nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTGTCGTGGATG
GGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCTATGTGAACC
ATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGTATTTTAGTG
ACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTGGAGAAAGCA
TGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGCACACAGGAT
TAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTCTTTCGCTCC
CTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCATTTGGATAC

>84307_84307_4_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361125_CDK14_chr7_90741856_ENST00000436577_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------
>84307_84307_5_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000265741_length(transcript)=4151nt_BP=442nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTG
TCGTGGATGGGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCT
ATGTGAACCATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGT
ATTTTAGTGACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTG
GAGAAAGCATGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGC
ACACAGGATTAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTC
TTTCGCTCCCTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCA
TTTGGATACCTTGTGATTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCATGTATTCTTTTCAGTCTTTTGTGTTT
GATTTTGTTTGATTTCCCTCTGCAGCACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAATACATTAAGACAACAC
ATTTGGTGTTCACACTTCTTCAGTAATGTCTGAACTTGAAAGCCACAGAGTGGCATAAAACAATGTGTGTTTTCTTTGAGAGCAGTGCAC
ATTTTGCAACCACTAGGAAGGAAATTTTCTGCTAAAGCAAACCCCTGTTCTCTGACTTGACAACTTGGCCCCGGACTGTGGGGCCCCACC
TGTTGCTTACCTTTTGAGGTAATTTTGCAAATGTGGTTTTTTTACTTGGAAATAACTGCACATTTATATATAGGATATTGGACTCTGCTT
AGCATTTTCAAGCCACATAGCATGACTGTTTTTTGAATAGGTTGGAATTGAAAAAACAATTATCAAACGTTAAGAACAAAGACAGGGATA
AATTGCTTACATTTCAACCTCTGGAGATTGAGGTAACTTTTTGTGTCTGGGTCTTGTCAACATCTAATTTTTTTCCATCCATTCTGTTAC
ACTTTGTATTTTCTAACTGGAGAAAAGAGTGAGGAACAGAATGTTTTAAATCTGGTGCAAAAGAACTATATCTGCTGGATGAGCCTTGAA
AGCAGTCTTGGCCTGTTAGGGCTTACAAAGTAAATTACAAAGTGATCCAGTTCAAAGTTTGCTTAGTTACAACAAAGCACCTTTAAAAAA
AATACATTTTAAAAAAACATTCCAAGCCAATTGGAAGACATCATTGGGTTCTTACTTTAAGACATCTCCTGGAATAACTGTTCAAATGCA
GGTTTTAGAAACAATGCAGGAATCTTGCTTTAAAGATGAAAAAGGGAATGGGCCAGCTTCCCTTACTCAAGGAGTTGAGGGACCTTGGAG
GATGAAGGCGAGTATGTGACACTGGAGAAAAGTGGACCAGGCATGTCTTTTGCTTTGATCTGGAGGGAGGGCTGCCTGATGCAGGCCGGC
TCCCAGTGGGGCAGGCCTCGCTGCAGAATGCCCAGTAGTACTGCGGCCAAGGGGACAGTTAGGAGACTTCATCTAAAGCATGAAACCTAG
CTCCTCTACACACAAATTCCTATGGAAATACCTTTGTGTACAGTGTCTTACATTTTCCTATTAGTCAGAAAGAAGGAGAGAATGAGTGAG
TGCTTGAAATGTGTCATACTGTTTTAGGATCAAGACTAGGAATTAGGAGCCAGGTTGACAAGGACTTTTTCTGAGAGTTGGGTGAGGGTA
AAGCTTTTCTATAATCAAGCTCAATACACCAAGGAAACTGGATCCAGAATTCCTAAACTTTAAAATGGTACTGTCTGCGGAGTGGAGTAT
GGATGGTTATGTCAAAGTCATAGTTCATCCTATCCAGATGTAGCATTCATGGTAAACTTTTAAGTGCTAAGCAAGGAATTATTTACTGAT
TGGTTTTAAAGAGAGCAGAAAACACCCAAGTGTAGAATGTCTACTGTTTGCTACCTAGAAATCTTTTCCATTCCTCTTTCATACATTCCA
ACCCACTGGAAGTCTTTAGAGGTATTTTGATTTAAAGTATACTTAAATTAGGATTTCTTAAAGAAAACATAGGGAGAAAACTTTACATGC
AATTAAAAATGGACTTTCCTGTGATTTGTTTTTAATCATTCATTTGGAGAAGAGGCATGACCTTTGTATTTCACTAAGTTTAAAGCAAGA
GCAACTGATGATTAAATGTTGCTTTTTAATAAGGTTTTTAACTTGAAAATTTGAAAATATTTAATGTTGAAAGACTTCAATTAGGGCTAT
TAGAGTTATATCTCCCTGTCGTAGGCAGCTTCTTCGGAGAAGTGAAATATAACATTACTCAGTGGACGGAGAAATCTGTTTTGTTACAGA
GACATGCCTCTCAGAAGGTCAGGAGGTTTTGAGTACCTATCCTTGCCACCCATACAGGAAATCCAAAGTTTGGTGTCTCTCTCTCTCTGT
CTCTTTCTTTCTCTTTCTCCCCCCAAACCCCTCTCACTCCCTCCCTCCCTCTCTCCTTCCCCTATTTGCAATCATATTCTCCCTCTGCTT
CTTTTCTCTTCTGCCCTCCTTGTGGGCAGTCATGAAAATCAATTCAGACTGTGTTGATTAGCAGATTTATTATTCTATTGAGAAAGCACT
GGAATGTTTTGTGAGATTATTTTTATATGAAGGAATAGCCTGAACTCAAACAGATGGTAAGAATAGTACAAACACCTTAGCACATCACTG
CACACACAGTATTCTGAAAGGAGATTTGACACTTAATTCCCATTTTCTTAAAATAACAGTTTTGTTGACTTAAAAATATGAGATACATAG
GATGTGAAAAAAAATGTTTGCAGTACTCAGCAAAAAATAGGGTACATAAAGCAGGGTGGCTGTCCATCCACTGATTCTGGGGTGAGAAGC
GATTTCTACCTCGCAAGAGTGACTAGAAAGTTTCTAGGAGCACCTCCAGGCTTGCAAAGAAAGTGAGGCCTCTTGGTATCCTTTCCTCAG
TGTGTATATGACAGCCAGTATAATCAATACCCTAGGTTATGCGTCTATATGATACTCATCTGTGAATATTATTGGTTTTGTAATCTTTGT
TATATAAGAGGATGTTTAGGCTGTATATACTGGGGTAGATTATTGCCTGCCCCTTATACATAGGAATATGCTGCATAATTGCGCATAACT
TCCATCTCCCTTACTGGCTTGTAGGCAGAGGAAACTGTATATGTTACTGCCTTGTACTTTTCTCATACACCAAAAACACACCAAAAAAAT
CAATAAAATAAGCAATCTTCTATTCTCATTCCTTTTCCCACAGCAGCATATTTTAGAGGCACATACAAAACCTACATTCTCTAGTTGGGA
GTGGATTTTTAAAGTTTTCCTTTTATCTTTTATTTTTTTTTGTATGATGCACTGAGATGTGTACTTTCTAACAGGGGATTGGTACCTAAG
AAATGTGGTAGCATTATTCAGAAAACTATTATACTTTCAAATGACACATAGTAAGGAGAATGGAATAATACATGTTGCATATTTGTTACC
AGTTGTAATTTGTCTGTATTATGAAAGATGTAATGGTTTGTCAGCTGTCACTGTTGTTTTCTTGTAACATGATATGGAATAAAGTATAGC

>84307_84307_5_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000265741_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------
>84307_84307_6_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000380050_length(transcript)=4152nt_BP=442nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTG
TCGTGGATGGGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCT
ATGTGAACCATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGT
ATTTTAGTGACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTG
GAGAAAGCATGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGC
ACACAGGATTAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTC
TTTCGCTCCCTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCA
TTTGGATACCTTGTGATTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCATGTATTCTTTTCAGTCTTTTGTGTTT
GATTTTGTTTGATTTCCCTCTGCAGCACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAATACATTAAGACAACAC
ATTTGGTGTTCACACTTCTTCAGTAATGTCTGAACTTGAAAGCCACAGAGTGGCATAAAACAATGTGTGTTTTCTTTGAGAGCAGTGCAC
ATTTTGCAACCACTAGGAAGGAAATTTTCTGCTAAAGCAAACCCCTGTTCTCTGACTTGACAACTTGGCCCCGGACTGTGGGGCCCCACC
TGTTGCTTACCTTTTGAGGTAATTTTGCAAATGTGGTTTTTTTACTTGGAAATAACTGCACATTTATATATAGGATATTGGACTCTGCTT
AGCATTTTCAAGCCACATAGCATGACTGTTTTTTGAATAGGTTGGAATTGAAAAAACAATTATCAAACGTTAAGAACAAAGACAGGGATA
AATTGCTTACATTTCAACCTCTGGAGATTGAGGTAACTTTTTGTGTCTGGGTCTTGTCAACATCTAATTTTTTTCCATCCATTCTGTTAC
ACTTTGTATTTTCTAACTGGAGAAAAGAGTGAGGAACAGAATGTTTTAAATCTGGTGCAAAAGAACTATATCTGCTGGATGAGCCTTGAA
AGCAGTCTTGGCCTGTTAGGGCTTACAAAGTAAATTACAAAGTGATCCAGTTCAAAGTTTGCTTAGTTACAACAAAGCACCTTTAAAAAA
AATACATTTTAAAAAAACATTCCAAGCCAATTGGAAGACATCATTGGGTTCTTACTTTAAGACATCTCCTGGAATAACTGTTCAAATGCA
GGTTTTAGAAACAATGCAGGAATCTTGCTTTAAAGATGAAAAAGGGAATGGGCCAGCTTCCCTTACTCAAGGAGTTGAGGGACCTTGGAG
GATGAAGGCGAGTATGTGACACTGGAGAAAAGTGGACCAGGCATGTCTTTTGCTTTGATCTGGAGGGAGGGCTGCCTGATGCAGGCCGGC
TCCCAGTGGGGCAGGCCTCGCTGCAGAATGCCCAGTAGTACTGCGGCCAAGGGGACAGTTAGGAGACTTCATCTAAAGCATGAAACCTAG
CTCCTCTACACACAAATTCCTATGGAAATACCTTTGTGTACAGTGTCTTACATTTTCCTATTAGTCAGAAAGAAGGAGAGAATGAGTGAG
TGCTTGAAATGTGTCATACTGTTTTAGGATCAAGACTAGGAATTAGGAGCCAGGTTGACAAGGACTTTTTCTGAGAGTTGGGTGAGGGTA
AAGCTTTTCTATAATCAAGCTCAATACACCAAGGAAACTGGATCCAGAATTCCTAAACTTTAAAATGGTACTGTCTGCGGAGTGGAGTAT
GGATGGTTATGTCAAAGTCATAGTTCATCCTATCCAGATGTAGCATTCATGGTAAACTTTTAAGTGCTAAGCAAGGAATTATTTACTGAT
TGGTTTTAAAGAGAGCAGAAAACACCCAAGTGTAGAATGTCTACTGTTTGCTACCTAGAAATCTTTTCCATTCCTCTTTCATACATTCCA
ACCCACTGGAAGTCTTTAGAGGTATTTTGATTTAAAGTATACTTAAATTAGGATTTCTTAAAGAAAACATAGGGAGAAAACTTTACATGC
AATTAAAAATGGACTTTCCTGTGATTTGTTTTTAATCATTCATTTGGAGAAGAGGCATGACCTTTGTATTTCACTAAGTTTAAAGCAAGA
GCAACTGATGATTAAATGTTGCTTTTTAATAAGGTTTTTAACTTGAAAATTTGAAAATATTTAATGTTGAAAGACTTCAATTAGGGCTAT
TAGAGTTATATCTCCCTGTCGTAGGCAGCTTCTTCGGAGAAGTGAAATATAACATTACTCAGTGGACGGAGAAATCTGTTTTGTTACAGA
GACATGCCTCTCAGAAGGTCAGGAGGTTTTGAGTACCTATCCTTGCCACCCATACAGGAAATCCAAAGTTTGGTGTCTCTCTCTCTCTGT
CTCTTTCTTTCTCTTTCTCCCCCCAAACCCCTCTCACTCCCTCCCTCCCTCTCTCCTTCCCCTATTTGCAATCATATTCTCCCTCTGCTT
CTTTTCTCTTCTGCCCTCCTTGTGGGCAGTCATGAAAATCAATTCAGACTGTGTTGATTAGCAGATTTATTATTCTATTGAGAAAGCACT
GGAATGTTTTGTGAGATTATTTTTATATGAAGGAATAGCCTGAACTCAAACAGATGGTAAGAATAGTACAAACACCTTAGCACATCACTG
CACACACAGTATTCTGAAAGGAGATTTGACACTTAATTCCCATTTTCTTAAAATAACAGTTTTGTTGACTTAAAAATATGAGATACATAG
GATGTGAAAAAAAATGTTTGCAGTACTCAGCAAAAAATAGGGTACATAAAGCAGGGTGGCTGTCCATCCACTGATTCTGGGGTGAGAAGC
GATTTCTACCTCGCAAGAGTGACTAGAAAGTTTCTAGGAGCACCTCCAGGCTTGCAAAGAAAGTGAGGCCTCTTGGTATCCTTTCCTCAG
TGTGTATATGACAGCCAGTATAATCAATACCCTAGGTTATGCGTCTATATGATACTCATCTGTGAATATTATTGGTTTTGTAATCTTTGT
TATATAAGAGGATGTTTAGGCTGTATATACTGGGGTAGATTATTGCCTGCCCCTTATACATAGGAATATGCTGCATAATTGCGCATAACT
TCCATCTCCCTTACTGGCTTGTAGGCAGAGGAAACTGTATATGTTACTGCCTTGTACTTTTCTCATACACCAAAAACACACCAAAAAAAT
CAATAAAATAAGCAATCTTCTATTCTCATTCCTTTTCCCACAGCAGCATATTTTAGAGGCACATACAAAACCTACATTCTCTAGTTGGGA
GTGGATTTTTAAAGTTTTCCTTTTATCTTTTATTTTTTTTTGTATGATGCACTGAGATGTGTACTTTCTAACAGGGGATTGGTACCTAAG
AAATGTGGTAGCATTATTCAGAAAACTATTATACTTTCAAATGACACATAGTAAGGAGAATGGAATAATACATGTTGCATATTTGTTACC
AGTTGTAATTTGTCTGTATTATGAAAGATGTAATGGTTTGTCAGCTGTCACTGTTGTTTTCTTGTAACATGATATGGAATAAAGTATAGC

>84307_84307_6_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000380050_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------
>84307_84307_7_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000406263_length(transcript)=4147nt_BP=442nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTG
TCGTGGATGGGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCT
ATGTGAACCATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGT
ATTTTAGTGACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTG
GAGAAAGCATGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGC
ACACAGGATTAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTC
TTTCGCTCCCTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCA
TTTGGATACCTTGTGATTTCCAAGAACTACGTGAAGATTAAGCTTTGCTTACTGATACATGGCATGTATTCTTTTCAGTCTTTTGTGTTT
GATTTTGTTTGATTTCCCTCTGCAGCACAGCGTCTCTGTAAAGGTTTTTATGCTTTCACCAGCCATGTCTTAAATACATTAAGACAACAC
ATTTGGTGTTCACACTTCTTCAGTAATGTCTGAACTTGAAAGCCACAGAGTGGCATAAAACAATGTGTGTTTTCTTTGAGAGCAGTGCAC
ATTTTGCAACCACTAGGAAGGAAATTTTCTGCTAAAGCAAACCCCTGTTCTCTGACTTGACAACTTGGCCCCGGACTGTGGGGCCCCACC
TGTTGCTTACCTTTTGAGGTAATTTTGCAAATGTGGTTTTTTTACTTGGAAATAACTGCACATTTATATATAGGATATTGGACTCTGCTT
AGCATTTTCAAGCCACATAGCATGACTGTTTTTTGAATAGGTTGGAATTGAAAAAACAATTATCAAACGTTAAGAACAAAGACAGGGATA
AATTGCTTACATTTCAACCTCTGGAGATTGAGGTAACTTTTTGTGTCTGGGTCTTGTCAACATCTAATTTTTTTCCATCCATTCTGTTAC
ACTTTGTATTTTCTAACTGGAGAAAAGAGTGAGGAACAGAATGTTTTAAATCTGGTGCAAAAGAACTATATCTGCTGGATGAGCCTTGAA
AGCAGTCTTGGCCTGTTAGGGCTTACAAAGTAAATTACAAAGTGATCCAGTTCAAAGTTTGCTTAGTTACAACAAAGCACCTTTAAAAAA
AATACATTTTAAAAAAACATTCCAAGCCAATTGGAAGACATCATTGGGTTCTTACTTTAAGACATCTCCTGGAATAACTGTTCAAATGCA
GGTTTTAGAAACAATGCAGGAATCTTGCTTTAAAGATGAAAAAGGGAATGGGCCAGCTTCCCTTACTCAAGGAGTTGAGGGACCTTGGAG
GATGAAGGCGAGTATGTGACACTGGAGAAAAGTGGACCAGGCATGTCTTTTGCTTTGATCTGGAGGGAGGGCTGCCTGATGCAGGCCGGC
TCCCAGTGGGGCAGGCCTCGCTGCAGAATGCCCAGTAGTACTGCGGCCAAGGGGACAGTTAGGAGACTTCATCTAAAGCATGAAACCTAG
CTCCTCTACACACAAATTCCTATGGAAATACCTTTGTGTACAGTGTCTTACATTTTCCTATTAGTCAGAAAGAAGGAGAGAATGAGTGAG
TGCTTGAAATGTGTCATACTGTTTTAGGATCAAGACTAGGAATTAGGAGCCAGGTTGACAAGGACTTTTTCTGAGAGTTGGGTGAGGGTA
AAGCTTTTCTATAATCAAGCTCAATACACCAAGGAAACTGGATCCAGAATTCCTAAACTTTAAAATGGTACTGTCTGCGGAGTGGAGTAT
GGATGGTTATGTCAAAGTCATAGTTCATCCTATCCAGATGTAGCATTCATGGTAAACTTTTAAGTGCTAAGCAAGGAATTATTTACTGAT
TGGTTTTAAAGAGAGCAGAAAACACCCAAGTGTAGAATGTCTACTGTTTGCTACCTAGAAATCTTTTCCATTCCTCTTTCATACATTCCA
ACCCACTGGAAGTCTTTAGAGGTATTTTGATTTAAAGTATACTTAAATTAGGATTTCTTAAAGAAAACATAGGGAGAAAACTTTACATGC
AATTAAAAATGGACTTTCCTGTGATTTGTTTTTAATCATTCATTTGGAGAAGAGGCATGACCTTTGTATTTCACTAAGTTTAAAGCAAGA
GCAACTGATGATTAAATGTTGCTTTTTAATAAGGTTTTTAACTTGAAAATTTGAAAATATTTAATGTTGAAAGACTTCAATTAGGGCTAT
TAGAGTTATATCTCCCTGTCGTAGGCAGCTTCTTCGGAGAAGTGAAATATAACATTACTCAGTGGACGGAGAAATCTGTTTTGTTACAGA
GACATGCCTCTCAGAAGGTCAGGAGGTTTTGAGTACCTATCCTTGCCACCCATACAGGAAATCCAAAGTTTGGTGTCTCTCTCTCTCTGT
CTCTTTCTTTCTCTTTCTCCCCCCAAACCCCTCTCACTCCCTCCCTCCCTCTCTCCTTCCCCTATTTGCAATCATATTCTCCCTCTGCTT
CTTTTCTCTTCTGCCCTCCTTGTGGGCAGTCATGAAAATCAATTCAGACTGTGTTGATTAGCAGATTTATTATTCTATTGAGAAAGCACT
GGAATGTTTTGTGAGATTATTTTTATATGAAGGAATAGCCTGAACTCAAACAGATGGTAAGAATAGTACAAACACCTTAGCACATCACTG
CACACACAGTATTCTGAAAGGAGATTTGACACTTAATTCCCATTTTCTTAAAATAACAGTTTTGTTGACTTAAAAATATGAGATACATAG
GATGTGAAAAAAAATGTTTGCAGTACTCAGCAAAAAATAGGGTACATAAAGCAGGGTGGCTGTCCATCCACTGATTCTGGGGTGAGAAGC
GATTTCTACCTCGCAAGAGTGACTAGAAAGTTTCTAGGAGCACCTCCAGGCTTGCAAAGAAAGTGAGGCCTCTTGGTATCCTTTCCTCAG
TGTGTATATGACAGCCAGTATAATCAATACCCTAGGTTATGCGTCTATATGATACTCATCTGTGAATATTATTGGTTTTGTAATCTTTGT
TATATAAGAGGATGTTTAGGCTGTATATACTGGGGTAGATTATTGCCTGCCCCTTATACATAGGAATATGCTGCATAATTGCGCATAACT
TCCATCTCCCTTACTGGCTTGTAGGCAGAGGAAACTGTATATGTTACTGCCTTGTACTTTTCTCATACACCAAAAACACACCAAAAAAAT
CAATAAAATAAGCAATCTTCTATTCTCATTCCTTTTCCCACAGCAGCATATTTTAGAGGCACATACAAAACCTACATTCTCTAGTTGGGA
GTGGATTTTTAAAGTTTTCCTTTTATCTTTTATTTTTTTTTGTATGATGCACTGAGATGTGTACTTTCTAACAGGGGATTGGTACCTAAG
AAATGTGGTAGCATTATTCAGAAAACTATTATACTTTCAAATGACACATAGTAAGGAGAATGGAATAATACATGTTGCATATTTGTTACC
AGTTGTAATTTGTCTGTATTATGAAAGATGTAATGGTTTGTCAGCTGTCACTGTTGTTTTCTTGTAACATGATATGGAATAAAGTATAGC

>84307_84307_7_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000406263_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------
>84307_84307_8_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000436577_length(transcript)=924nt_BP=442nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGTGTTATGTGCCAAGAACCTTGCAAAGAAAGACTTCTTCAGGCTCCCTGACCCTTTTGCAAAGATTG
TCGTGGATGGGTCTGGGCAGTGCCACTCAACCGACACTGTGAAAAACACATTGGACCCAAAGTGGAACCAGCACTATGATCTGCTCAGCT
ATGTGAACCATGCAGAGGACCTGGCCTCCAAGCTCCTACAATGTTCCCCAAAGAACAGACTGTCGGCACAGGCTGCCTTGAGCCACGAGT
ATTTTAGTGACCTGCCGCCACGGCTATGGGAACTCACCGACATGTCTTCTATTTTTACTGTCCCAAATGTGAGATTGCAACCAGAAGCTG
GAGAAAGCATGCGGGCCTTTGGGAAAAACAATAGTTATGGCAAAAGTCTATCAAACAGCAAGCACTGACAAGCAGCACATTCTCAAGAGC
ACACAGGATTAAGTTGTCATCATTCTGGGAAGAAAAAAAAAACATTAATGAAGAGGCCAATAATATGAAGGGAATCATGGATCAGTTTTC
TTTCGCTCCCTGTGGTGGATTTCACTTACAAGAAAATTGAAGCTGGCAAGACCCTGTTTTCTCTGCAATTTATTTAAAACCTTGCACGCA

>84307_84307_8_SMURF1-CDK14_SMURF1_chr7_98658221_ENST00000361368_CDK14_chr7_90741856_ENST00000436577_length(amino acids)=225AA_BP=141
MEAARVRAPQQAPISRLDHPPAARTPGPRSLCPGSDPGAQPGAVTLRRRRRGRAGPGWGAVALDPRLPDRWREMSNPGTRRNGSSIKIRL
TVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMURF1-CDK14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMURF1-CDK14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMURF1-CDK14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource