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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SMURF1-PTCD1 (FusionGDB2 ID:84322)

Fusion Gene Summary for SMURF1-PTCD1

Fusion gene summary

Fusion gene information	Fusion gene name: SMURF1-PTCD1
	Fusion gene ID: 84322
		Hgene	Tgene
	Gene symbol	SMURF1	PTCD1
	Gene ID	57154	26024
	Gene name	SMAD specific E3 ubiquitin protein ligase 1	pentatricopeptide repeat domain 1
	Synonyms	-	-
	Cytomap	7q22.1	7q22.1
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase SMURF1E3 ubiquitin ligase SMURF1HECT-type E3 ubiquitin transferase SMURF1Smad ubiquitination regulatory factor 1Smad-specific E3 ubiquitin ligase 1hSMURF1	pentatricopeptide repeat-containing protein 1, mitochondrial
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000361125, ENST00000361368, ENST00000480055,	ENST00000485746, ENST00000292478, ENST00000555673,
Fusion gene scores	* DoF score	19 X 8 X 12=1824	3 X 2 X 3=18
	# samples	24	4
	** MAII score	log2(24/1824*10)=-2.92599941855622 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SMURF1 [Title/Abstract] AND PTCD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMURF1(98741348)-PTCD1(99027429), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SMURF1	GO:0000209	protein polyubiquitination	19937093
Hgene	SMURF1	GO:0006511	ubiquitin-dependent protein catabolic process	10458166\|12151385\|19937093
Hgene	SMURF1	GO:0006611	protein export from nucleus	11278251
Hgene	SMURF1	GO:0016567	protein ubiquitination	11278251
Hgene	SMURF1	GO:0030154	cell differentiation	10458166
Hgene	SMURF1	GO:0030509	BMP signaling pathway	21572392
Hgene	SMURF1	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	11278251\|12151385
Hgene	SMURF1	GO:0030514	negative regulation of BMP signaling pathway	27214554
Hgene	SMURF1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	11278251\|12151385
Hgene	SMURF1	GO:0032801	receptor catabolic process	12151385
Hgene	SMURF1	GO:0034394	protein localization to cell surface	12151385
Hgene	SMURF1	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	11278251
Hgene	SMURF1	GO:1903861	positive regulation of dendrite extension	23999003
Tgene	PTCD1	GO:0042780	tRNA 3'-end processing	21857155

Fusion gene breakpoints across SMURF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PTCD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OQ-01A	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
ChimerDB4	ESCA	TCGA-L5-A4OQ	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-

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Fusion Gene ORF analysis for SMURF1-PTCD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000361125	ENST00000485746	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
5CDS-5UTR	ENST00000361125	ENST00000485746	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
5CDS-5UTR	ENST00000361368	ENST00000485746	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
5CDS-5UTR	ENST00000361368	ENST00000485746	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361125	ENST00000292478	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361125	ENST00000292478	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361125	ENST00000555673	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361125	ENST00000555673	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361368	ENST00000292478	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361368	ENST00000292478	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361368	ENST00000555673	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
In-frame	ENST00000361368	ENST00000555673	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
intron-3CDS	ENST00000480055	ENST00000292478	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
intron-3CDS	ENST00000480055	ENST00000292478	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
intron-3CDS	ENST00000480055	ENST00000555673	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
intron-3CDS	ENST00000480055	ENST00000555673	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-
intron-5UTR	ENST00000480055	ENST00000485746	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-
intron-5UTR	ENST00000480055	ENST00000485746	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361368	SMURF1	chr7	98741348	-	ENST00000292478	PTCD1	chr7	99027429	-	5031	294	294	1802	502
ENST00000361368	SMURF1	chr7	98741348	-	ENST00000555673	PTCD1	chr7	99027429	-	2021	294	294	1802	502
ENST00000361125	SMURF1	chr7	98741348	-	ENST00000292478	PTCD1	chr7	99027429	-	5112	375	375	1883	502
ENST00000361125	SMURF1	chr7	98741348	-	ENST00000555673	PTCD1	chr7	99027429	-	2102	375	375	1883	502
ENST00000361368	SMURF1	chr7	98741349	-	ENST00000292478	PTCD1	chr7	99027429	-	5031	294	294	1802	502
ENST00000361368	SMURF1	chr7	98741349	-	ENST00000555673	PTCD1	chr7	99027429	-	2021	294	294	1802	502
ENST00000361125	SMURF1	chr7	98741349	-	ENST00000292478	PTCD1	chr7	99027429	-	5112	375	375	1883	502
ENST00000361125	SMURF1	chr7	98741349	-	ENST00000555673	PTCD1	chr7	99027429	-	2102	375	375	1883	502

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361368	ENST00000292478	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-	0.005317466	0.9946825
ENST00000361368	ENST00000555673	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-	0.017284036	0.98271596
ENST00000361125	ENST00000292478	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-	0.0055393	0.9944607
ENST00000361125	ENST00000555673	SMURF1	chr7	98741348	-	PTCD1	chr7	99027429	-	0.015550864	0.9844491
ENST00000361368	ENST00000292478	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-	0.005317466	0.9946825
ENST00000361368	ENST00000555673	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-	0.017284036	0.98271596
ENST00000361125	ENST00000292478	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-	0.0055393	0.9944607
ENST00000361125	ENST00000555673	SMURF1	chr7	98741349	-	PTCD1	chr7	99027429	-	0.015550864	0.9844491

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Fusion Genomic Features for SMURF1-PTCD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMURF1-PTCD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:98741348/chr7:99027429)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

207_245

198

701.0

Repeat

Note=PPR 3

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

246_280

198

701.0

Repeat

Note=PPR 4

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

281_317

198

701.0

Repeat

Note=PPR 5

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

318_354

198

701.0

Repeat

Note=PPR 6

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

519_553

198

701.0

Repeat

Note=PPR 7

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

554_585

198

701.0

Repeat

Note=PPR 8

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

586_620

198

701.0

Repeat

Note=PPR 9

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

207_245

198

701.0

Repeat

Note=PPR 3

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

246_280

198

701.0

Repeat

Note=PPR 4

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

281_317

198

701.0

Repeat

Note=PPR 5

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

318_354

198

701.0

Repeat

Note=PPR 6

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

519_553

198

701.0

Repeat

Note=PPR 7

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

554_585

198

701.0

Repeat

Note=PPR 8

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

586_620

198

701.0

Repeat

Note=PPR 9

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361125

1_120

758.0

Domain

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361125

234_267

758.0

Domain

WW 1

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361125

306_339

758.0

Domain

WW 2

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361125

420_757

758.0

Domain

HECT

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361368

1_120

732.0

Domain

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361368

234_267

732.0

Domain

WW 1

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361368

306_339

732.0

Domain

WW 2

Hgene

SMURF1

chr7:98741348

chr7:99027429

ENST00000361368

420_757

732.0

Domain

HECT

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361125

1_120

758.0

Domain

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361125

234_267

758.0

Domain

WW 1

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361125

306_339

758.0

Domain

WW 2

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361125

420_757

758.0

Domain

HECT

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361368

1_120

732.0

Domain

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361368

234_267

732.0

Domain

WW 1

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361368

306_339

732.0

Domain

WW 2

Hgene

SMURF1

chr7:98741349

chr7:99027429

ENST00000361368

420_757

732.0

Domain

HECT

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

135_171

198

701.0

Repeat

Note=PPR 1

Tgene

PTCD1

chr7:98741348

chr7:99027429

ENST00000292478

172_206

198

701.0

Repeat

Note=PPR 2

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

135_171

198

701.0

Repeat

Note=PPR 1

Tgene

PTCD1

chr7:98741349

chr7:99027429

ENST00000292478

172_206

198

701.0

Repeat

Note=PPR 2

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Fusion Gene Sequence for SMURF1-PTCD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>84322_84322_1_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361125_PTCD1_chr7_99027429_ENST00000292478_length(transcript)=5112nt_BP=375nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAGTCCCCCTGG
AAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATACCACGCGCTG
CTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTCACAGAGGAG
ACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATGCTGAGTCTA
GGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCCTCAGAGCTG
CTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAGGCAGGCAAC
CTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAGCCTCCGGAA
GCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCCCTGAAGCCA
CCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACCCCAGCTGAC
CGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTCACGCTACTG
GCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTGACATTCTTT
AACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGCCTCGTCCCC
AACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAGTCCCAGGTG
ACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTGAAGGACATG
AAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGGTACCAAGGG
AAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACCCCGCACCCC
TGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGGTGATGGGAG
CACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGGGGAAGAGCC
AGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAGGTCCAAGTG
CAGCTCCAGCCACCTTTGCGTGTCACCTTCACGGGACTTCCAGCTCCAGCTACCTTTGTGTGTCACCTCACACACCACAAGGGGGCTGGG
GCATCTGGTCCCTGGGGCCTGGGCCGCCCCGCCGGGTTCCATAGGCCGATGCTCTGAAAGAAGAGACGTGGGGCTCGAGAGATTTAAAGA
TTTTATTTTTACAAATCACAGCTGATAGACAGCGAAGCCTTCCCCATAGAGACCGTGCTCCAACTCGGGCCTGGGGCACTGCTCGCTGCT
CCCAGGAAGGGGGTGGCGTGACAGGCAGGAACCTGCGAAGTCCAGAGTCCAGGGTGGAGCGCGCCAGCCTCAGCCAGAGCAGCCACGACA
GCCACAGTGTGTGCACTCGATGATGCGGCCCTGCAACGGAGGAGGACAGTGAGACGATGCCACTGCGCCACGCTCGCCCCTGCACACTCA
CATATGTGGCAACCCTCCCACGAAGGACCTGCCACCATGCCATATAGGGACACACCTCAGAAACCCTTCCTTGACAGCTCTGGACAGGGA
AAATTTGGCTCCCTCATGAAGGTAGAACCAGCTGCTGTTGACACCGAGGTTACATCTGTATGTCTATTTATAATATGTTCTGCAAATCCA
ACACACGTTTGCCAATCAAGAAAAAGAAATCGGTGTGAATGAGTCTCGTTATTCTGCTAAGTGAGCATGACAGACCCTGCGATGAGCAGA
CGTGGCTCTGCTACTGTTTGGGGACTTCAGGGGGGCCTCTGGGCTGGTACACTCTGGTGGGGGAAGAGGGCAGGAGACTATGCACTTGAG
TCACACCCTTCTGGCCCAGAGCCCCCCAGAAAGAAGGGTCTTGTCCCCCAGGCCTGGTGCGGCCCAACACTTGGCCAGCCAGAAAGCCCT
AGAACAGTGGCTTGTGTTTATTTTACTTTTTCAAGTTCTTTTTTTGGAAGAACAAGACCATAGTTTAAGTAAACAGGATCCTCTGGTGAA
ACCCAGGTAAGTCTACAGCGGGCTGTTTTGGCCACAGGGCTGAAGCAGCACCCCAGCCCACCAGCCCCTGACCTGGACTCCTTGTGGAAT
CTGGGCACTCAGAGGAAGGGGGCTTCTGCCACTCTGCCACCTGTCCCTGCCTCCATCAGAAAACCAACACCCCAGTCTTCCGTCGGGGAG
GCGGCCCTTGCTCGCCCCCACTGCTCAGTACCCAAGTCCTCAGCATCCAGCCACAGCTCTCCATTGTCAGTCTCACTGCAGCATAAAGGG
GACTCATGTGAAGAGGCCCCTGTGTGGAGCTGGGGAAAAGAAGGCCAGGCTGGCAGATGGGCGGTGGGGCCAACAACTGTGCTGAGGGGC
TGCACTGAGCGGCCACTGCTGTGACTCTGCCTCGGGCCACAGCTGCCTTTCAGAGGGGCTTGGAACCGGATGGAGCTCAGCTCCTGTCCC
TCAGCACCACTCCTGAGGCGCCTGGCCTAGGAGTGGTACTTGGAACAGAAAGTTCTGAAAGAAGAAACACAGTGGGCTGGGCGCAGTAGC
TCATGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGAGCAACATTGAGAA
ACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGTCCCAGCTACTCAGGAGGATGAGGCAGGAGAACC
GCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATGGCATCACTGCACTCCAGCCTGGGCGACAAAGCAAGACTCCGTCTTGGGGG
GGCGGGAAAGATAGTGATGGTAATGTTAAAGTATCACTGTGAGGACTGAAAGGGACAGGAACTCACTGGTTGTCCTTCCCTGATGTCACC
CTGCCACCACCTTGGGATTAGGGCTCCCCACCACCATTTCCTAAGTGAGGAAAGGGGTTCAGTAATTTGCCCAAAAGTGGAGTTGAGATT
GACCCCAGACCTAACAAACACACAGCCACACGCTGCCTCACATGGATTCCTGAATACAGGGACCCACTCCCACGAGGGAGAGCCAGCAGG
ACATCCAGGGACAAAACGACATTCCAGCCCAACCAAATAACATAAGATCCCTTGCAGTCGACTAAGGCAGAATTTTGAGCTGAAAACAAC
ACCAAGCTTGAGTGTCAGACATTACCACTTCCAGCTTGCTTTTGGGCACGCGGCAGATGCAGTTCGTCCCGAAGTTGGTGTCCCGTGTCT
GAATGCACCGCAGGCAGCACAAGTTCTCATATCCTTGCTTTTTCCATTTTGCAATCAGGTTTTTGTCTGCATAGCCTTCTTTAATACAAT
ATTCATAGAGTTCTGTCAAAAAGATGGGGAAAGAGCATCAGGCCATGGTCTAAAAACCTTCCCCACCCTTGATCAAAAAAAGCATTCAGG
CCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAGGACCAGCCCG
GCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTACTCGGGCGTGGTAGCAGCTGTAATCCCAGCTACTTAGGAGGCTGAG
GCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGTAGTGACCTGAGGTCGTGCCACTGGACTCCAGCCTGGGTGACAGCGAAACTCCA
TCTCAAAAAAAAAAAGGCATTCAGTATTGCAACGGGACAGTCCTTGGAGGAGGAACAAAAAAAAAAAGTACTTAGGCCAGGCAAGGTGCC
TCACACCTGTAATCCCAGCACTTTTGGAAGCCAACGCCAGAGGATCATTTGAGTTAAGAAACCAGCCTGGGCCAAGGGCCCATCTCCACA
AAAAATTTAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTCACAGCTACTCAGGAGGTTGAGGTGAGAGGATCCCTTGAGCCCAGA

>84322_84322_1_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361125_PTCD1_chr7_99027429_ENST00000292478_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------
>84322_84322_2_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361125_PTCD1_chr7_99027429_ENST00000555673_length(transcript)=2102nt_BP=375nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAGTCCCCCTGG
AAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATACCACGCGCTG
CTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTCACAGAGGAG
ACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATGCTGAGTCTA
GGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCCTCAGAGCTG
CTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAGGCAGGCAAC
CTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAGCCTCCGGAA
GCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCCCTGAAGCCA
CCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACCCCAGCTGAC
CGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTCACGCTACTG
GCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTGACATTCTTT
AACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGCCTCGTCCCC
AACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAGTCCCAGGTG
ACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTGAAGGACATG
AAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGGTACCAAGGG
AAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACCCCGCACCCC
TGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGGTGATGGGAG
CACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGGGGAAGAGCC
AGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAGGTCCAAGTG

>84322_84322_2_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361125_PTCD1_chr7_99027429_ENST00000555673_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------
>84322_84322_3_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361368_PTCD1_chr7_99027429_ENST00000292478_length(transcript)=5031nt_BP=294nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAG
TCCCCCTGGAAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATAC
CACGCGCTGCTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTC
ACAGAGGAGACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATG
CTGAGTCTAGGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCC
TCAGAGCTGCTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAG
GCAGGCAACCTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAG
CCTCCGGAAGCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCC
CTGAAGCCACCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACC
CCAGCTGACCGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTC
ACGCTACTGGCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTG
ACATTCTTTAACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGC
CTCGTCCCCAACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAG
TCCCAGGTGACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTG
AAGGACATGAAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGG
TACCAAGGGAAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACC
CCGCACCCCTGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGG
TGATGGGAGCACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGG
GGAAGAGCCAGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAG
GTCCAAGTGCAGCTCCAGCCACCTTTGCGTGTCACCTTCACGGGACTTCCAGCTCCAGCTACCTTTGTGTGTCACCTCACACACCACAAG
GGGGCTGGGGCATCTGGTCCCTGGGGCCTGGGCCGCCCCGCCGGGTTCCATAGGCCGATGCTCTGAAAGAAGAGACGTGGGGCTCGAGAG
ATTTAAAGATTTTATTTTTACAAATCACAGCTGATAGACAGCGAAGCCTTCCCCATAGAGACCGTGCTCCAACTCGGGCCTGGGGCACTG
CTCGCTGCTCCCAGGAAGGGGGTGGCGTGACAGGCAGGAACCTGCGAAGTCCAGAGTCCAGGGTGGAGCGCGCCAGCCTCAGCCAGAGCA
GCCACGACAGCCACAGTGTGTGCACTCGATGATGCGGCCCTGCAACGGAGGAGGACAGTGAGACGATGCCACTGCGCCACGCTCGCCCCT
GCACACTCACATATGTGGCAACCCTCCCACGAAGGACCTGCCACCATGCCATATAGGGACACACCTCAGAAACCCTTCCTTGACAGCTCT
GGACAGGGAAAATTTGGCTCCCTCATGAAGGTAGAACCAGCTGCTGTTGACACCGAGGTTACATCTGTATGTCTATTTATAATATGTTCT
GCAAATCCAACACACGTTTGCCAATCAAGAAAAAGAAATCGGTGTGAATGAGTCTCGTTATTCTGCTAAGTGAGCATGACAGACCCTGCG
ATGAGCAGACGTGGCTCTGCTACTGTTTGGGGACTTCAGGGGGGCCTCTGGGCTGGTACACTCTGGTGGGGGAAGAGGGCAGGAGACTAT
GCACTTGAGTCACACCCTTCTGGCCCAGAGCCCCCCAGAAAGAAGGGTCTTGTCCCCCAGGCCTGGTGCGGCCCAACACTTGGCCAGCCA
GAAAGCCCTAGAACAGTGGCTTGTGTTTATTTTACTTTTTCAAGTTCTTTTTTTGGAAGAACAAGACCATAGTTTAAGTAAACAGGATCC
TCTGGTGAAACCCAGGTAAGTCTACAGCGGGCTGTTTTGGCCACAGGGCTGAAGCAGCACCCCAGCCCACCAGCCCCTGACCTGGACTCC
TTGTGGAATCTGGGCACTCAGAGGAAGGGGGCTTCTGCCACTCTGCCACCTGTCCCTGCCTCCATCAGAAAACCAACACCCCAGTCTTCC
GTCGGGGAGGCGGCCCTTGCTCGCCCCCACTGCTCAGTACCCAAGTCCTCAGCATCCAGCCACAGCTCTCCATTGTCAGTCTCACTGCAG
CATAAAGGGGACTCATGTGAAGAGGCCCCTGTGTGGAGCTGGGGAAAAGAAGGCCAGGCTGGCAGATGGGCGGTGGGGCCAACAACTGTG
CTGAGGGGCTGCACTGAGCGGCCACTGCTGTGACTCTGCCTCGGGCCACAGCTGCCTTTCAGAGGGGCTTGGAACCGGATGGAGCTCAGC
TCCTGTCCCTCAGCACCACTCCTGAGGCGCCTGGCCTAGGAGTGGTACTTGGAACAGAAAGTTCTGAAAGAAGAAACACAGTGGGCTGGG
CGCAGTAGCTCATGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGAGCAA
CATTGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGTCCCAGCTACTCAGGAGGATGAGGC
AGGAGAACCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATGGCATCACTGCACTCCAGCCTGGGCGACAAAGCAAGACTCCG
TCTTGGGGGGGCGGGAAAGATAGTGATGGTAATGTTAAAGTATCACTGTGAGGACTGAAAGGGACAGGAACTCACTGGTTGTCCTTCCCT
GATGTCACCCTGCCACCACCTTGGGATTAGGGCTCCCCACCACCATTTCCTAAGTGAGGAAAGGGGTTCAGTAATTTGCCCAAAAGTGGA
GTTGAGATTGACCCCAGACCTAACAAACACACAGCCACACGCTGCCTCACATGGATTCCTGAATACAGGGACCCACTCCCACGAGGGAGA
GCCAGCAGGACATCCAGGGACAAAACGACATTCCAGCCCAACCAAATAACATAAGATCCCTTGCAGTCGACTAAGGCAGAATTTTGAGCT
GAAAACAACACCAAGCTTGAGTGTCAGACATTACCACTTCCAGCTTGCTTTTGGGCACGCGGCAGATGCAGTTCGTCCCGAAGTTGGTGT
CCCGTGTCTGAATGCACCGCAGGCAGCACAAGTTCTCATATCCTTGCTTTTTCCATTTTGCAATCAGGTTTTTGTCTGCATAGCCTTCTT
TAATACAATATTCATAGAGTTCTGTCAAAAAGATGGGGAAAGAGCATCAGGCCATGGTCTAAAAACCTTCCCCACCCTTGATCAAAAAAA
GCATTCAGGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAGG
ACCAGCCCGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTACTCGGGCGTGGTAGCAGCTGTAATCCCAGCTACTTAG
GAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGTAGTGACCTGAGGTCGTGCCACTGGACTCCAGCCTGGGTGACAGC
GAAACTCCATCTCAAAAAAAAAAAGGCATTCAGTATTGCAACGGGACAGTCCTTGGAGGAGGAACAAAAAAAAAAAGTACTTAGGCCAGG
CAAGGTGCCTCACACCTGTAATCCCAGCACTTTTGGAAGCCAACGCCAGAGGATCATTTGAGTTAAGAAACCAGCCTGGGCCAAGGGCCC
ATCTCCACAAAAAATTTAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTCACAGCTACTCAGGAGGTTGAGGTGAGAGGATCCCTT

>84322_84322_3_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361368_PTCD1_chr7_99027429_ENST00000292478_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------
>84322_84322_4_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361368_PTCD1_chr7_99027429_ENST00000555673_length(transcript)=2021nt_BP=294nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAG
TCCCCCTGGAAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATAC
CACGCGCTGCTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTC
ACAGAGGAGACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATG
CTGAGTCTAGGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCC
TCAGAGCTGCTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAG
GCAGGCAACCTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAG
CCTCCGGAAGCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCC
CTGAAGCCACCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACC
CCAGCTGACCGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTC
ACGCTACTGGCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTG
ACATTCTTTAACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGC
CTCGTCCCCAACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAG
TCCCAGGTGACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTG
AAGGACATGAAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGG
TACCAAGGGAAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACC
CCGCACCCCTGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGG
TGATGGGAGCACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGG
GGAAGAGCCAGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAG

>84322_84322_4_SMURF1-PTCD1_SMURF1_chr7_98741348_ENST00000361368_PTCD1_chr7_99027429_ENST00000555673_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------
>84322_84322_5_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361125_PTCD1_chr7_99027429_ENST00000292478_length(transcript)=5112nt_BP=375nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAGTCCCCCTGG
AAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATACCACGCGCTG
CTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTCACAGAGGAG
ACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATGCTGAGTCTA
GGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCCTCAGAGCTG
CTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAGGCAGGCAAC
CTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAGCCTCCGGAA
GCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCCCTGAAGCCA
CCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACCCCAGCTGAC
CGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTCACGCTACTG
GCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTGACATTCTTT
AACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGCCTCGTCCCC
AACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAGTCCCAGGTG
ACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTGAAGGACATG
AAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGGTACCAAGGG
AAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACCCCGCACCCC
TGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGGTGATGGGAG
CACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGGGGAAGAGCC
AGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAGGTCCAAGTG
CAGCTCCAGCCACCTTTGCGTGTCACCTTCACGGGACTTCCAGCTCCAGCTACCTTTGTGTGTCACCTCACACACCACAAGGGGGCTGGG
GCATCTGGTCCCTGGGGCCTGGGCCGCCCCGCCGGGTTCCATAGGCCGATGCTCTGAAAGAAGAGACGTGGGGCTCGAGAGATTTAAAGA
TTTTATTTTTACAAATCACAGCTGATAGACAGCGAAGCCTTCCCCATAGAGACCGTGCTCCAACTCGGGCCTGGGGCACTGCTCGCTGCT
CCCAGGAAGGGGGTGGCGTGACAGGCAGGAACCTGCGAAGTCCAGAGTCCAGGGTGGAGCGCGCCAGCCTCAGCCAGAGCAGCCACGACA
GCCACAGTGTGTGCACTCGATGATGCGGCCCTGCAACGGAGGAGGACAGTGAGACGATGCCACTGCGCCACGCTCGCCCCTGCACACTCA
CATATGTGGCAACCCTCCCACGAAGGACCTGCCACCATGCCATATAGGGACACACCTCAGAAACCCTTCCTTGACAGCTCTGGACAGGGA
AAATTTGGCTCCCTCATGAAGGTAGAACCAGCTGCTGTTGACACCGAGGTTACATCTGTATGTCTATTTATAATATGTTCTGCAAATCCA
ACACACGTTTGCCAATCAAGAAAAAGAAATCGGTGTGAATGAGTCTCGTTATTCTGCTAAGTGAGCATGACAGACCCTGCGATGAGCAGA
CGTGGCTCTGCTACTGTTTGGGGACTTCAGGGGGGCCTCTGGGCTGGTACACTCTGGTGGGGGAAGAGGGCAGGAGACTATGCACTTGAG
TCACACCCTTCTGGCCCAGAGCCCCCCAGAAAGAAGGGTCTTGTCCCCCAGGCCTGGTGCGGCCCAACACTTGGCCAGCCAGAAAGCCCT
AGAACAGTGGCTTGTGTTTATTTTACTTTTTCAAGTTCTTTTTTTGGAAGAACAAGACCATAGTTTAAGTAAACAGGATCCTCTGGTGAA
ACCCAGGTAAGTCTACAGCGGGCTGTTTTGGCCACAGGGCTGAAGCAGCACCCCAGCCCACCAGCCCCTGACCTGGACTCCTTGTGGAAT
CTGGGCACTCAGAGGAAGGGGGCTTCTGCCACTCTGCCACCTGTCCCTGCCTCCATCAGAAAACCAACACCCCAGTCTTCCGTCGGGGAG
GCGGCCCTTGCTCGCCCCCACTGCTCAGTACCCAAGTCCTCAGCATCCAGCCACAGCTCTCCATTGTCAGTCTCACTGCAGCATAAAGGG
GACTCATGTGAAGAGGCCCCTGTGTGGAGCTGGGGAAAAGAAGGCCAGGCTGGCAGATGGGCGGTGGGGCCAACAACTGTGCTGAGGGGC
TGCACTGAGCGGCCACTGCTGTGACTCTGCCTCGGGCCACAGCTGCCTTTCAGAGGGGCTTGGAACCGGATGGAGCTCAGCTCCTGTCCC
TCAGCACCACTCCTGAGGCGCCTGGCCTAGGAGTGGTACTTGGAACAGAAAGTTCTGAAAGAAGAAACACAGTGGGCTGGGCGCAGTAGC
TCATGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGAGCAACATTGAGAA
ACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGTCCCAGCTACTCAGGAGGATGAGGCAGGAGAACC
GCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATGGCATCACTGCACTCCAGCCTGGGCGACAAAGCAAGACTCCGTCTTGGGGG
GGCGGGAAAGATAGTGATGGTAATGTTAAAGTATCACTGTGAGGACTGAAAGGGACAGGAACTCACTGGTTGTCCTTCCCTGATGTCACC
CTGCCACCACCTTGGGATTAGGGCTCCCCACCACCATTTCCTAAGTGAGGAAAGGGGTTCAGTAATTTGCCCAAAAGTGGAGTTGAGATT
GACCCCAGACCTAACAAACACACAGCCACACGCTGCCTCACATGGATTCCTGAATACAGGGACCCACTCCCACGAGGGAGAGCCAGCAGG
ACATCCAGGGACAAAACGACATTCCAGCCCAACCAAATAACATAAGATCCCTTGCAGTCGACTAAGGCAGAATTTTGAGCTGAAAACAAC
ACCAAGCTTGAGTGTCAGACATTACCACTTCCAGCTTGCTTTTGGGCACGCGGCAGATGCAGTTCGTCCCGAAGTTGGTGTCCCGTGTCT
GAATGCACCGCAGGCAGCACAAGTTCTCATATCCTTGCTTTTTCCATTTTGCAATCAGGTTTTTGTCTGCATAGCCTTCTTTAATACAAT
ATTCATAGAGTTCTGTCAAAAAGATGGGGAAAGAGCATCAGGCCATGGTCTAAAAACCTTCCCCACCCTTGATCAAAAAAAGCATTCAGG
CCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAGGACCAGCCCG
GCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTACTCGGGCGTGGTAGCAGCTGTAATCCCAGCTACTTAGGAGGCTGAG
GCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGTAGTGACCTGAGGTCGTGCCACTGGACTCCAGCCTGGGTGACAGCGAAACTCCA
TCTCAAAAAAAAAAAGGCATTCAGTATTGCAACGGGACAGTCCTTGGAGGAGGAACAAAAAAAAAAAGTACTTAGGCCAGGCAAGGTGCC
TCACACCTGTAATCCCAGCACTTTTGGAAGCCAACGCCAGAGGATCATTTGAGTTAAGAAACCAGCCTGGGCCAAGGGCCCATCTCCACA
AAAAATTTAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTCACAGCTACTCAGGAGGTTGAGGTGAGAGGATCCCTTGAGCCCAGA

>84322_84322_5_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361125_PTCD1_chr7_99027429_ENST00000292478_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------
>84322_84322_6_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361125_PTCD1_chr7_99027429_ENST00000555673_length(transcript)=2102nt_BP=375nt
GGCAGCGGCGGAAGCGGCGAGGGCGGCGGGCGTCCGGCTCTGAGGTGGTGGAGGCGGCGGAGGCGGCGGCGGAGGCGGCGGCGGCTCGGG
ACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCCGGACGCCTG
GGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGGCCGGGCCGG
GCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCTCCAGCATCA
AGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAGTCCCCCTGG
AAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATACCACGCGCTG
CTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTCACAGAGGAG
ACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATGCTGAGTCTA
GGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCCTCAGAGCTG
CTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAGGCAGGCAAC
CTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAGCCTCCGGAA
GCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCCCTGAAGCCA
CCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACCCCAGCTGAC
CGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTCACGCTACTG
GCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTGACATTCTTT
AACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGCCTCGTCCCC
AACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAGTCCCAGGTG
ACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTGAAGGACATG
AAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGGTACCAAGGG
AAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACCCCGCACCCC
TGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGGTGATGGGAG
CACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGGGGAAGAGCC
AGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAGGTCCAAGTG

>84322_84322_6_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361125_PTCD1_chr7_99027429_ENST00000555673_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------
>84322_84322_7_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361368_PTCD1_chr7_99027429_ENST00000292478_length(transcript)=5031nt_BP=294nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAG
TCCCCCTGGAAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATAC
CACGCGCTGCTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTC
ACAGAGGAGACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATG
CTGAGTCTAGGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCC
TCAGAGCTGCTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAG
GCAGGCAACCTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAG
CCTCCGGAAGCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCC
CTGAAGCCACCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACC
CCAGCTGACCGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTC
ACGCTACTGGCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTG
ACATTCTTTAACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGC
CTCGTCCCCAACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAG
TCCCAGGTGACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTG
AAGGACATGAAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGG
TACCAAGGGAAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACC
CCGCACCCCTGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGG
TGATGGGAGCACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGG
GGAAGAGCCAGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAG
GTCCAAGTGCAGCTCCAGCCACCTTTGCGTGTCACCTTCACGGGACTTCCAGCTCCAGCTACCTTTGTGTGTCACCTCACACACCACAAG
GGGGCTGGGGCATCTGGTCCCTGGGGCCTGGGCCGCCCCGCCGGGTTCCATAGGCCGATGCTCTGAAAGAAGAGACGTGGGGCTCGAGAG
ATTTAAAGATTTTATTTTTACAAATCACAGCTGATAGACAGCGAAGCCTTCCCCATAGAGACCGTGCTCCAACTCGGGCCTGGGGCACTG
CTCGCTGCTCCCAGGAAGGGGGTGGCGTGACAGGCAGGAACCTGCGAAGTCCAGAGTCCAGGGTGGAGCGCGCCAGCCTCAGCCAGAGCA
GCCACGACAGCCACAGTGTGTGCACTCGATGATGCGGCCCTGCAACGGAGGAGGACAGTGAGACGATGCCACTGCGCCACGCTCGCCCCT
GCACACTCACATATGTGGCAACCCTCCCACGAAGGACCTGCCACCATGCCATATAGGGACACACCTCAGAAACCCTTCCTTGACAGCTCT
GGACAGGGAAAATTTGGCTCCCTCATGAAGGTAGAACCAGCTGCTGTTGACACCGAGGTTACATCTGTATGTCTATTTATAATATGTTCT
GCAAATCCAACACACGTTTGCCAATCAAGAAAAAGAAATCGGTGTGAATGAGTCTCGTTATTCTGCTAAGTGAGCATGACAGACCCTGCG
ATGAGCAGACGTGGCTCTGCTACTGTTTGGGGACTTCAGGGGGGCCTCTGGGCTGGTACACTCTGGTGGGGGAAGAGGGCAGGAGACTAT
GCACTTGAGTCACACCCTTCTGGCCCAGAGCCCCCCAGAAAGAAGGGTCTTGTCCCCCAGGCCTGGTGCGGCCCAACACTTGGCCAGCCA
GAAAGCCCTAGAACAGTGGCTTGTGTTTATTTTACTTTTTCAAGTTCTTTTTTTGGAAGAACAAGACCATAGTTTAAGTAAACAGGATCC
TCTGGTGAAACCCAGGTAAGTCTACAGCGGGCTGTTTTGGCCACAGGGCTGAAGCAGCACCCCAGCCCACCAGCCCCTGACCTGGACTCC
TTGTGGAATCTGGGCACTCAGAGGAAGGGGGCTTCTGCCACTCTGCCACCTGTCCCTGCCTCCATCAGAAAACCAACACCCCAGTCTTCC
GTCGGGGAGGCGGCCCTTGCTCGCCCCCACTGCTCAGTACCCAAGTCCTCAGCATCCAGCCACAGCTCTCCATTGTCAGTCTCACTGCAG
CATAAAGGGGACTCATGTGAAGAGGCCCCTGTGTGGAGCTGGGGAAAAGAAGGCCAGGCTGGCAGATGGGCGGTGGGGCCAACAACTGTG
CTGAGGGGCTGCACTGAGCGGCCACTGCTGTGACTCTGCCTCGGGCCACAGCTGCCTTTCAGAGGGGCTTGGAACCGGATGGAGCTCAGC
TCCTGTCCCTCAGCACCACTCCTGAGGCGCCTGGCCTAGGAGTGGTACTTGGAACAGAAAGTTCTGAAAGAAGAAACACAGTGGGCTGGG
CGCAGTAGCTCATGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGAGCAA
CATTGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGCATGCCTGTAGTCCCAGCTACTCAGGAGGATGAGGC
AGGAGAACCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATGGCATCACTGCACTCCAGCCTGGGCGACAAAGCAAGACTCCG
TCTTGGGGGGGCGGGAAAGATAGTGATGGTAATGTTAAAGTATCACTGTGAGGACTGAAAGGGACAGGAACTCACTGGTTGTCCTTCCCT
GATGTCACCCTGCCACCACCTTGGGATTAGGGCTCCCCACCACCATTTCCTAAGTGAGGAAAGGGGTTCAGTAATTTGCCCAAAAGTGGA
GTTGAGATTGACCCCAGACCTAACAAACACACAGCCACACGCTGCCTCACATGGATTCCTGAATACAGGGACCCACTCCCACGAGGGAGA
GCCAGCAGGACATCCAGGGACAAAACGACATTCCAGCCCAACCAAATAACATAAGATCCCTTGCAGTCGACTAAGGCAGAATTTTGAGCT
GAAAACAACACCAAGCTTGAGTGTCAGACATTACCACTTCCAGCTTGCTTTTGGGCACGCGGCAGATGCAGTTCGTCCCGAAGTTGGTGT
CCCGTGTCTGAATGCACCGCAGGCAGCACAAGTTCTCATATCCTTGCTTTTTCCATTTTGCAATCAGGTTTTTGTCTGCATAGCCTTCTT
TAATACAATATTCATAGAGTTCTGTCAAAAAGATGGGGAAAGAGCATCAGGCCATGGTCTAAAAACCTTCCCCACCCTTGATCAAAAAAA
GCATTCAGGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAGG
ACCAGCCCGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTACTCGGGCGTGGTAGCAGCTGTAATCCCAGCTACTTAG
GAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGTAGTGACCTGAGGTCGTGCCACTGGACTCCAGCCTGGGTGACAGC
GAAACTCCATCTCAAAAAAAAAAAGGCATTCAGTATTGCAACGGGACAGTCCTTGGAGGAGGAACAAAAAAAAAAAGTACTTAGGCCAGG
CAAGGTGCCTCACACCTGTAATCCCAGCACTTTTGGAAGCCAACGCCAGAGGATCATTTGAGTTAAGAAACCAGCCTGGGCCAAGGGCCC
ATCTCCACAAAAAATTTAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTCACAGCTACTCAGGAGGTTGAGGTGAGAGGATCCCTT

>84322_84322_7_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361368_PTCD1_chr7_99027429_ENST00000292478_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------
>84322_84322_8_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361368_PTCD1_chr7_99027429_ENST00000555673_length(transcript)=2021nt_BP=294nt
CGGCTCGGGACTGGGCTCGGCTGGAAGCAGCGAGGGTCAGAGCGCCGCAGCAAGCGCCGATCTCCCGGCTCGACCATCCGCCTGCCGCCC
GGACGCCTGGGCCGCGGAGTTTGTGTCCCGGCTCGGACCCCGGCGCCCAGCCCGGAGCCGTAACCTTGAGGCGGCGGCGGCGGGGCCGGG
CCGGGCCGGGCTGGGGGGCGGTGGCGCTGGATCCGCGGCTGCCCGATCGTTGGCGGGAGATGTCGAACCCCGGGACACGCAGGAACGGCT
CCAGCATCAAGATCCGTCTGACAGATGAAAAAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAG
TCCCCCTGGAAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCCAAAAACTTCGAGCTCAACTTGAAAACATAC
CACGCGCTGCTGAAGATGGCTGCCAAGTGCGCAGACCTTAGGATGTGCCTCGATGTGTTCAAGGAAATCATCCACAAAGGGCACGTGGTC
ACAGAGGAGACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTCCGGTACGCCCTCCAGGTGTGGCGGCTGATG
CTGAGTCTAGGGCTACAGCCGAGCCGGGACAGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCC
TCAGAGCTGCTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGGCAGCGGCCAAGGAGGACAGCCCAGGCCAAG
GCAGGCAACCTCATGTCAGCCATGCTGCATGTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAG
CCTCCGGAAGCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCCAGCCACACAGCAGCCCTCACCGCAGTGGCC
CTGAAGCCACCTCCCGTGGAGCTGGAAGTCAACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACC
CCAGCTGACCGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAGCACAGGCAGCAGCCCGACATCAGGACCCTC
ACGCTACTGGCCGAGGTGGTGGAGTCCGGGAGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTG
ACATTCTTTAACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAGGCGCTGTTGCCGGTCCTGGCAAAGAGGGGC
CTCGTCCCCAACCTGCAGACATTCTGCAACCTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAGAAG
TCCCAGGTGACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAGCTGAACTACACCTATCTCATCAGCATCTTG
AAGGACATGAAGCAGAACAGGGTCCCGGTGAACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGG
TACCAAGGGAAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAGTGGCTGACAGTGATGCCCGCAGAGGAAACC
CCGCACCCCTGGCAGAAGTTCCGGACCAAGCCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGG
TGATGGGAGCACAGCTGGAACAATGTGCTCGGCCCCCAGTGCTCTGTGGGAGCCCCAGGACAAGTGAGCTGGTGTCACCTCCTGCCTGGG
GGAAGAGCCAGGCCCTGAGGAACAGCCGCAGCGTGTCACAGGTGTTGGTGAGGACACACACTAGGCCCAAGGTGCCTGTGCTCCCAGCAG

>84322_84322_8_SMURF1-PTCD1_SMURF1_chr7_98741349_ENST00000361368_PTCD1_chr7_99027429_ENST00000555673_length(amino acids)=502AA_BP=0
MKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFL
LMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAM
LHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALI
GGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTF
CNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SMURF1-PTCD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SMURF1-PTCD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SMURF1-PTCD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source