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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMYD3-WLS (FusionGDB2 ID:84387)

Fusion Gene Summary for SMYD3-WLS

check button Fusion gene summary
Fusion gene informationFusion gene name: SMYD3-WLS
Fusion gene ID: 84387
HgeneTgene
Gene symbol

SMYD3

WLS

Gene ID

64754

79971

Gene nameSET and MYND domain containing 3Wnt ligand secretion mediator
SynonymsKMT3E|ZMYND1|ZNFN3A1|bA74P14.1C1orf139|EVI|GPR177|MRP|mig-14
Cytomap

1q44

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1protein wntless homologG protein-coupled receptor 177integral membrane protein GPR177protein evenness interrupted homologputative NF-kappa-B-activating protein 373putative NFkB activating protein 373wntless Wnt ligand secretion mediator
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000388985, ENST00000403792, 
ENST00000490107, ENST00000541742, 
ENST00000366517, 		ENST00000370971, 
ENST00000370976, ENST00000491811, 
ENST00000262348, ENST00000354777, 
ENST00000540432, 
Fusion gene scores* DoF score22 X 13 X 10=286013 X 8 X 7=728
# samples 2413
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/728*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMYD3 [Title/Abstract] AND WLS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMYD3(246518333)-WLS(68659910), # samples:3
Anticipated loss of major functional domain due to fusion event.SMYD3-WLS seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SMYD3-WLS seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SMYD3-WLS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SMYD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1N6-01ASMYD3chr1

246518333

-WLSchr1

68659910

-


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Fusion Gene ORF analysis for SMYD3-WLS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000388985ENST00000370971SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000388985ENST00000370976SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000388985ENST00000491811SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000403792ENST00000370971SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000403792ENST00000370976SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000403792ENST00000491811SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000490107ENST00000370971SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000490107ENST00000370976SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000490107ENST00000491811SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000541742ENST00000370971SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000541742ENST00000370976SMYD3chr1

246518333

-WLSchr1

68659910

-
5CDS-intronENST00000541742ENST00000491811SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000388985ENST00000262348SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000388985ENST00000354777SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000388985ENST00000540432SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000403792ENST00000262348SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000403792ENST00000354777SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000403792ENST00000540432SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000490107ENST00000262348SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000490107ENST00000354777SMYD3chr1

246518333

-WLSchr1

68659910

-
Frame-shiftENST00000490107ENST00000540432SMYD3chr1

246518333

-WLSchr1

68659910

-
In-frameENST00000541742ENST00000262348SMYD3chr1

246518333

-WLSchr1

68659910

-
In-frameENST00000541742ENST00000354777SMYD3chr1

246518333

-WLSchr1

68659910

-
In-frameENST00000541742ENST00000540432SMYD3chr1

246518333

-WLSchr1

68659910

-
intron-3CDSENST00000366517ENST00000262348SMYD3chr1

246518333

-WLSchr1

68659910

-
intron-3CDSENST00000366517ENST00000354777SMYD3chr1

246518333

-WLSchr1

68659910

-
intron-3CDSENST00000366517ENST00000540432SMYD3chr1

246518333

-WLSchr1

68659910

-
intron-intronENST00000366517ENST00000370971SMYD3chr1

246518333

-WLSchr1

68659910

-
intron-intronENST00000366517ENST00000370976SMYD3chr1

246518333

-WLSchr1

68659910

-
intron-intronENST00000366517ENST00000491811SMYD3chr1

246518333

-WLSchr1

68659910

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541742SMYD3chr1246518333-ENST00000540432WLSchr168659910-18861812101712500
ENST00000541742SMYD3chr1246518333-ENST00000354777WLSchr168659910-18661812041706500
ENST00000541742SMYD3chr1246518333-ENST00000262348WLSchr168659910-25691812101700496

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541742ENST00000540432SMYD3chr1246518333-WLSchr168659910-0.0031163130.9968837
ENST00000541742ENST00000354777SMYD3chr1246518333-WLSchr168659910-0.0031051110.99689484
ENST00000541742ENST00000262348SMYD3chr1246518333-WLSchr168659910-0.0016332710.9983668

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Fusion Genomic Features for SMYD3-WLS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMYD3-WLS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:246518333/chr1:68659910)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMYD3chr1:246518333chr1:68659910ENST00000388985-21214_1676429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246518333chr1:68659910ENST00000490107-21214_1617370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246518333chr1:68659910ENST00000541742-21214_1617370.0RegionS-adenosyl-L-methionine binding
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012254_26835542.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012290_30335542.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012325_33135542.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012353_38035542.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST0000026234801237_23235542.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012402_43135542.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012453_47135542.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012493_54135542.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012254_26835544.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012290_30335544.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012325_33135544.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012353_38035544.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST0000035477701237_23235544.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012402_43135544.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012453_47135544.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012493_54135544.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST000003709760111_150451.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011254_2680451.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011290_3030451.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011325_3310451.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011353_3800451.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST0000037097601137_2320451.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011402_4310451.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011453_4710451.0Topological domainLumenal
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011493_5410451.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012233_25335542.0TransmembraneHelical%3B Name%3D2
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012269_28935542.0TransmembraneHelical%3B Name%3D3
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012304_32435542.0TransmembraneHelical%3B Name%3D4
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012332_35235542.0TransmembraneHelical%3B Name%3D5
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012381_40135542.0TransmembraneHelical%3B Name%3D6
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012432_45235542.0TransmembraneHelical%3B Name%3D7
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012472_49235542.0TransmembraneHelical%3B Name%3D8
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012233_25335544.0TransmembraneHelical%3B Name%3D2
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012269_28935544.0TransmembraneHelical%3B Name%3D3
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012304_32435544.0TransmembraneHelical%3B Name%3D4
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012332_35235544.0TransmembraneHelical%3B Name%3D5
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012381_40135544.0TransmembraneHelical%3B Name%3D6
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012432_45235544.0TransmembraneHelical%3B Name%3D7
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012472_49235544.0TransmembraneHelical%3B Name%3D8
TgeneWLSchr1:246518333chr1:68659910ENST0000037097601116_360451.0TransmembraneHelical%3B Name%3D1
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011233_2530451.0TransmembraneHelical%3B Name%3D2
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011269_2890451.0TransmembraneHelical%3B Name%3D3
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011304_3240451.0TransmembraneHelical%3B Name%3D4
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011332_3520451.0TransmembraneHelical%3B Name%3D5
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011381_4010451.0TransmembraneHelical%3B Name%3D6
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011432_4520451.0TransmembraneHelical%3B Name%3D7
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011472_4920451.0TransmembraneHelical%3B Name%3D8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMYD3chr1:246518333chr1:68659910ENST00000388985-2124_24076429.0DomainSET
HgeneSMYD3chr1:246518333chr1:68659910ENST00000490107-2124_24017370.0DomainSET
HgeneSMYD3chr1:246518333chr1:68659910ENST00000541742-2124_24017370.0DomainSET
HgeneSMYD3chr1:246518333chr1:68659910ENST00000388985-212205_20676429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246518333chr1:68659910ENST00000490107-212205_20617370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246518333chr1:68659910ENST00000541742-212205_20617370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246518333chr1:68659910ENST00000388985-21249_8776429.0Zinc fingerMYND-type
HgeneSMYD3chr1:246518333chr1:68659910ENST00000490107-21249_8717370.0Zinc fingerMYND-type
HgeneSMYD3chr1:246518333chr1:68659910ENST00000541742-21249_8717370.0Zinc fingerMYND-type
TgeneWLSchr1:246518333chr1:68659910ENST000002623480121_1535542.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST000003547770121_1535544.0Topological domainCytoplasmic
TgeneWLSchr1:246518333chr1:68659910ENST0000026234801216_3635542.0TransmembraneHelical%3B Name%3D1
TgeneWLSchr1:246518333chr1:68659910ENST0000035477701216_3635544.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for SMYD3-WLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84387_84387_1_SMYD3-WLS_SMYD3_chr1_246518333_ENST00000541742_WLS_chr1_68659910_ENST00000262348_length(transcript)=2569nt_BP=181nt
GAGGTGGATTTGAGAGATACCTCCCCTCCTTCTGCTCAGCTGCCTTGCAGTAATTAAACTCTTTCTCTGCTGCAACACCCCTACTGTTCT
CCGTGTATTGGCTTTTCTGGGCAGCAGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCA
GCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCT
TGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCAC
ATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAA
ATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGA
GTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATG
GAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAG
ATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATC
TTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATT
TCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGC
ATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTAT
TGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTC
TACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTT
CTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTAT
GAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTA
ACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTC
TTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGCGATCTGGGTGTCCATAGTGGGGAAGAA
CTCCAGCTCACCACCACTATCACCCATGTGGACGGACCCACTGAGATCTACAAGTTGACCCGCAAGGAGGCCCAGGAGTAGGAGGCTGCA
GCGCCCGGCTGGGACGGTCTCTCCATACCCCAGCCCCTCTAACTAGAGTGGGGAGCATGCCAGAGAGAGCTCAATGTACAAATGAATGCC
TCATGGCTCTTAGCTGTGGTTTCTTGGACCAGCGGCATGGACATTTGTCAGTTTGCCTTCTGACGGTAGCTTTTGGAGGAAGATTCCTGC
AGCCACTAATGCATTGTGTATGATAACAAAAACTCTGGTATGACACATTTTCTGTGATCATTGTTAATTAGTGACATAGTAACATCTGTA
GCAGCTGGTTAGTAAACCTCATGTGGGGGTGGGGTGGGGGTGTATTCCTTGGGGGATGGTTTGGGCCGAATGGGGAGTGGAATATTTGAC
ATTTTTCCTGTTTTAAATTCTAGGATAGATTTTAACATCCTTTGCGGTCCCAGTCCAAGGTAGGCTGGTGTCATAGTCTTCTCACTCCTA
ATCCATGACCACTGTTTTTTTCCTATTTATATCACCAGGTAGCCCACTGAGTTAATATTTAAGTTGTCAATAGATAAGTGTCCCTGTTTT
GTGGCATAATATAACTGAATTTCATGAGAAGATTTATTCCACCAGGGGTATTTCAGCTTTGAAACCAAATCTGTGTATCTAATACTAACC
AATCTGTTGGATGTGGGTTTTAAAAAATGTTTGCTAAACTACCCAAGTAAGATTTACTGTATTAAATGGCCTTCGGGTCTGAAAAGCTTT
TTTAACTTCTTGCTTAAAATGCGTTTTATTTTGATAAGATACTTCAAATAGCCTCCAAAAGTGTAGATCCAATCATTTAAATAAACCTGT

>84387_84387_1_SMYD3-WLS_SMYD3_chr1_246518333_ENST00000541742_WLS_chr1_68659910_ENST00000262348_length(amino acids)=496AA_BP=
MSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMD
VSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIH
QNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFW
IIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFR
NISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPS

--------------------------------------------------------------
>84387_84387_2_SMYD3-WLS_SMYD3_chr1_246518333_ENST00000541742_WLS_chr1_68659910_ENST00000354777_length(transcript)=1866nt_BP=181nt
GAGGTGGATTTGAGAGATACCTCCCCTCCTTCTGCTCAGCTGCCTTGCAGTAATTAAACTCTTTCTCTGCTGCAACACCCCTACTGTTCT
CCGTGTATTGGCTTTTCTGGGCAGCAGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCA
GGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGA
CCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCC
CTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGA
GAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCA
CGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATT
GGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAG
GATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATC
ATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATG
ACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTC
TATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAG
CAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGT
ATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGC
TTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGG
CTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAA
GGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCT
CTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGT
GCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTC
AACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACATTGATTGTACTTGTATACGCACACAAATACACTCATTT

>84387_84387_2_SMYD3-WLS_SMYD3_chr1_246518333_ENST00000541742_WLS_chr1_68659910_ENST00000354777_length(amino acids)=500AA_BP=
MSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMD
VSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIH
QNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFW
IIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFR
NISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPS

--------------------------------------------------------------
>84387_84387_3_SMYD3-WLS_SMYD3_chr1_246518333_ENST00000541742_WLS_chr1_68659910_ENST00000540432_length(transcript)=1886nt_BP=181nt
GAGGTGGATTTGAGAGATACCTCCCCTCCTTCTGCTCAGCTGCCTTGCAGTAATTAAACTCTTTCTCTGCTGCAACACCCCTACTGTTCT
CCGTGTATTGGCTTTTCTGGGCAGCAGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCA
GCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCT
TGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCAC
ATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAA
ATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGA
GTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATG
GAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAG
ATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATC
TTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATT
TCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGC
ATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTAT
TGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTC
TACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTT
CTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTAT
GAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTA
ACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTC
TTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAA
GATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATT
TGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACATTGATTGTACTTGTATACGCACACAAATACAC

>84387_84387_3_SMYD3-WLS_SMYD3_chr1_246518333_ENST00000541742_WLS_chr1_68659910_ENST00000540432_length(amino acids)=500AA_BP=
MSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMD
VSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIH
QNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFW
IIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFR
NISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMYD3-WLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWLSchr1:246518333chr1:68659910ENST00000262348012101_23235.333333333333336542.0Wnt proteins
TgeneWLSchr1:246518333chr1:68659910ENST00000354777012101_23235.333333333333336544.0Wnt proteins
TgeneWLSchr1:246518333chr1:68659910ENST00000370976011101_2320451.0Wnt proteins


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMYD3-WLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMYD3-WLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource