FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SNAI1-SLC9A8 (FusionGDB2 ID:84401)

Fusion Gene Summary for SNAI1-SLC9A8

check button Fusion gene summary
Fusion gene informationFusion gene name: SNAI1-SLC9A8
Fusion gene ID: 84401
HgeneTgene
Gene symbol

SNAI1

SLC9A8

Gene ID

6615

23315

Gene namesnail family transcriptional repressor 1solute carrier family 9 member A8
SynonymsSLUGH2|SNA|SNAH|SNAIL|SNAIL1|dJ710H13.1NHE-8|NHE8
Cytomap

20q13.13

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein SNAI1protein snaprotein snail homolog 1snail 1 homologsnail 1 zinc finger proteinsnail family zinc finger 1snail homolog 1sodium/hydrogen exchanger 8Na(+)/H(+) exchanger 8solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9 (sodium/hydrogen exchanger), member 8solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000244050, ENST00000541138, 
ENST00000361573, ENST00000417961, 
ENST00000490250, ENST00000539601, 
Fusion gene scores* DoF score2 X 3 X 2=1211 X 14 X 5=770
# samples 416
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/770*10)=-2.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNAI1 [Title/Abstract] AND SLC9A8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSNAI1(48599678)-SLC9A8(48479466), # samples:2
SNAI1(48599678)-SLC9A8(48481265), # samples:2
Anticipated loss of major functional domain due to fusion event.SNAI1-SLC9A8 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SNAI1-SLC9A8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNAI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11912130

HgeneSNAI1

GO:0001837

epithelial to mesenchymal transition

16096638

HgeneSNAI1

GO:0010957

negative regulation of vitamin D biosynthetic process

19502595


check buttonFusion gene breakpoints across SNAI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC9A8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5D6-01ASNAI1chr20

48599677

+SLC9A8chr20

48479465

+
ChimerDB4BRCATCGA-OL-A5D6-01ASNAI1chr20

48599678

+SLC9A8chr20

48479466

+
ChimerDB4BRCATCGA-OL-A5D6-01ASNAI1chr20

48599678

+SLC9A8chr20

48479471

+
ChimerDB4BRCATCGA-OL-A5D6-01ASNAI1chr20

48599678

-SLC9A8chr20

48481265

+
ChimerDB4BRCATCGA-OL-A5D6-01ASNAI1chr20

48599678

+SLC9A8chr20

48481265

+
ChimerDB4BRCATCGA-OL-A5D6SNAI1chr20

48599678

+SLC9A8chr20

48479465

+


Top

Fusion Gene ORF analysis for SNAI1-SLC9A8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000244050ENST00000541138SNAI1chr20

48599678

+SLC9A8chr20

48481265

+
5CDS-intronENST00000244050ENST00000361573SNAI1chr20

48599678

+SLC9A8chr20

48481265

+
5CDS-intronENST00000244050ENST00000417961SNAI1chr20

48599678

+SLC9A8chr20

48481265

+
5CDS-intronENST00000244050ENST00000490250SNAI1chr20

48599677

+SLC9A8chr20

48479465

+
5CDS-intronENST00000244050ENST00000490250SNAI1chr20

48599678

+SLC9A8chr20

48479466

+
5CDS-intronENST00000244050ENST00000490250SNAI1chr20

48599678

+SLC9A8chr20

48479471

+
5CDS-intronENST00000244050ENST00000490250SNAI1chr20

48599678

+SLC9A8chr20

48481265

+
5CDS-intronENST00000244050ENST00000490250SNAI1chr20

48599678

+SLC9A8chr20

48479465

+
5CDS-intronENST00000244050ENST00000539601SNAI1chr20

48599677

+SLC9A8chr20

48479465

+
5CDS-intronENST00000244050ENST00000539601SNAI1chr20

48599678

+SLC9A8chr20

48479466

+
5CDS-intronENST00000244050ENST00000539601SNAI1chr20

48599678

+SLC9A8chr20

48479471

+
5CDS-intronENST00000244050ENST00000539601SNAI1chr20

48599678

+SLC9A8chr20

48481265

+
5CDS-intronENST00000244050ENST00000539601SNAI1chr20

48599678

+SLC9A8chr20

48479465

+
5CDS-intronENST00000244050ENST00000541138SNAI1chr20

48599677

+SLC9A8chr20

48479465

+
5CDS-intronENST00000244050ENST00000541138SNAI1chr20

48599678

+SLC9A8chr20

48479466

+
5CDS-intronENST00000244050ENST00000541138SNAI1chr20

48599678

+SLC9A8chr20

48479471

+
5CDS-intronENST00000244050ENST00000541138SNAI1chr20

48599678

+SLC9A8chr20

48479465

+
Frame-shiftENST00000244050ENST00000361573SNAI1chr20

48599677

+SLC9A8chr20

48479465

+
Frame-shiftENST00000244050ENST00000361573SNAI1chr20

48599678

+SLC9A8chr20

48479466

+
Frame-shiftENST00000244050ENST00000361573SNAI1chr20

48599678

+SLC9A8chr20

48479471

+
Frame-shiftENST00000244050ENST00000361573SNAI1chr20

48599678

+SLC9A8chr20

48479465

+
Frame-shiftENST00000244050ENST00000417961SNAI1chr20

48599677

+SLC9A8chr20

48479465

+
Frame-shiftENST00000244050ENST00000417961SNAI1chr20

48599678

+SLC9A8chr20

48479466

+
Frame-shiftENST00000244050ENST00000417961SNAI1chr20

48599678

+SLC9A8chr20

48479471

+
Frame-shiftENST00000244050ENST00000417961SNAI1chr20

48599678

+SLC9A8chr20

48479465

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SNAI1-SLC9A8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SNAI1chr2048599678+SLC9A8chr2048481264+0.0012908560.9987092
SNAI1chr2048599678+SLC9A8chr2048479465+0.0001075980.99989235
SNAI1chr2048599678+SLC9A8chr2048479465+0.0001075980.99989235
SNAI1chr2048599678+SLC9A8chr2048481264+0.0012908560.9987092
SNAI1chr2048599678+SLC9A8chr2048479465+0.0001075980.99989235
SNAI1chr2048599678+SLC9A8chr2048479465+0.0001075980.99989235

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for SNAI1-SLC9A8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48599678/:48479466)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for SNAI1-SLC9A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for SNAI1-SLC9A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SNAI1-SLC9A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SNAI1-SLC9A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource