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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SNHG14-STARD3 (FusionGDB2 ID:84515)

Fusion Gene Summary for SNHG14-STARD3

Fusion gene summary

Fusion gene information	Fusion gene name: SNHG14-STARD3
	Fusion gene ID: 84515
		Hgene	Tgene
	Gene symbol	SNHG14	STARD3
	Gene ID	104472715	10948
	Gene name	small nucleolar RNA host gene 14	StAR related lipid transfer domain containing 3
	Synonyms	115HG\|IC-SNURF-SNRPN\|LNCAT\|NCRNA00214\|U-UBE3A-ATS\|UBE3A-AS\|UBE3A-AS1\|UBE3A-ATS\|UBE3AATS	CAB1\|MLN64\|es64
	Cytomap	15q11.2	17q12
	Type of gene	ncRNA	protein-coding
	Description	UBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)	stAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein related
	Modification date	20200303	20200313
	UniProtAcc	.	STARD3NL
	Ensembl transtripts involved in fusion gene	ENST00000452731, ENST00000363358, ENST00000365067, ENST00000365306, ENST00000384430, ENST00000384733, ENST00000390982, ENST00000414175, ENST00000424208, ENST00000424333, ENST00000441592, ENST00000450809, ENST00000453082, ENST00000456576, ENST00000459433, ENST00000516123, ENST00000546682, ENST00000547292, ENST00000549804, ENST00000551077, ENST00000551361, ENST00000551631, ENST00000551938, ENST00000553108, ENST00000553134, ENST00000553149, ENST00000554726, ENST00000580438,	ENST00000336308, ENST00000394250, ENST00000544210, ENST00000578232, ENST00000580611,
Fusion gene scores	* DoF score	24 X 26 X 4=2496	15 X 10 X 10=1500
	# samples	27	24
	** MAII score	log2(27/2496*10)=-3.20858662181142 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/1500*10)=-2.64385618977472 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SNHG14 [Title/Abstract] AND STARD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SNHG14(25497480)-STARD3(37816464), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	STARD3	GO:0030301	cholesterol transport	28377464
Tgene	STARD3	GO:0099044	vesicle tethering to endoplasmic reticulum	24105263\|28377464

Fusion gene breakpoints across SNHG14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STARD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-UL-AAZ6-01A	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+

Top

Fusion Gene ORF analysis for SNHG14-STARD3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000452731	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
3UTR-intron	ENST00000452731	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
3UTR-intron	ENST00000452731	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
3UTR-intron	ENST00000452731	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
3UTR-intron	ENST00000452731	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000363358	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000365067	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000365306	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000384430	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000384733	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000390982	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000414175	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000424208	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000424333	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000441592	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000450809	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000453082	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000456576	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000459433	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000516123	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000546682	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000547292	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000549804	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000551077	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000551361	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000551631	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000551938	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000553108	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000553134	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000553149	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000554726	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-3CDS	ENST00000580438	ENST00000336308	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000363358	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000363358	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000363358	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000363358	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365067	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365067	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365067	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365067	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365306	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365306	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365306	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000365306	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384430	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384430	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384430	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384430	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384733	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384733	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384733	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000384733	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000390982	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000390982	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000390982	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000390982	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000414175	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000414175	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000414175	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000414175	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424208	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424208	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424208	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424208	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424333	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424333	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424333	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000424333	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000441592	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000441592	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000441592	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000441592	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000450809	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000450809	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000450809	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000450809	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000453082	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000453082	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000453082	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000453082	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000456576	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000456576	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000456576	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000456576	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000459433	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000459433	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000459433	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000459433	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000516123	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000516123	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000516123	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000516123	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000546682	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000546682	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000546682	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000546682	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000547292	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000547292	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000547292	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000547292	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000549804	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000549804	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000549804	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000549804	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551077	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551077	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551077	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551077	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551361	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551361	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551361	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551361	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551631	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551631	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551631	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551631	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551938	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551938	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551938	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000551938	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553108	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553108	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553108	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553108	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553134	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553134	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553134	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553134	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553149	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553149	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553149	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000553149	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000554726	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000554726	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000554726	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000554726	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000580438	ENST00000394250	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000580438	ENST00000544210	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000580438	ENST00000578232	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+
intron-intron	ENST00000580438	ENST00000580611	SNHG14	chr15	25497480	+	STARD3	chr17	37816464	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for SNHG14-STARD3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SNHG14	chr15	25497480	+	STARD3	chr17	37816463	+	0.00019603	0.99980396
SNHG14	chr15	25497480	+	STARD3	chr17	37816463	+	0.00019603	0.99980396

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SNHG14-STARD3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:25497480/:37816464)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	STARD3 STARD3NL
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	234

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for SNHG14-STARD3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SNHG14-STARD3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SNHG14-STARD3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SNHG14-STARD3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source