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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATXN7L1-EFCAB10 (FusionGDB2 ID:8453)

Fusion Gene Summary for ATXN7L1-EFCAB10

check button Fusion gene summary
Fusion gene informationFusion gene name: ATXN7L1-EFCAB10
Fusion gene ID: 8453
HgeneTgene
Gene symbol

ATXN7L1

EFCAB10

Gene ID

222255

100130771

Gene nameataxin 7 like 1EF-hand calcium binding domain 10
SynonymsATXN7L4-
Cytomap

7q22.3

7q22.3

Type of geneprotein-codingprotein-coding
Descriptionataxin-7-like protein 1ataxin 7-like 4ataxin-7-like protein 4EF-hand calcium-binding domain-containing protein 10EF-hand domain-containing protein
Modification date2020031320200313
UniProtAcc

Q9ULK2

A6NFE3

Ensembl transtripts involved in fusion geneENST00000318724, ENST00000419735, 
ENST00000478915, ENST00000388807, 
ENST00000472910, ENST00000477775, 
ENST00000490493, ENST00000460135, 
ENST00000480514, ENST00000485614, 
ENST00000486180, 
Fusion gene scores* DoF score13 X 10 X 5=6503 X 2 X 3=18
# samples 133
** MAII scorelog2(13/650*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATXN7L1 [Title/Abstract] AND EFCAB10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATXN7L1(105429050)-EFCAB10(105210018), # samples:1
EFCAB10(105208833)-ATXN7L1(105458723), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATXN7L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EFCAB10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-6743-01AATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-


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Fusion Gene ORF analysis for ATXN7L1-EFCAB10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000318724ENST00000490493ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
5CDS-5UTRENST00000419735ENST00000490493ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
5CDS-5UTRENST00000478915ENST00000490493ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
5CDS-intronENST00000318724ENST00000460135ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
5CDS-intronENST00000419735ENST00000460135ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
5CDS-intronENST00000478915ENST00000460135ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000318724ENST00000480514ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000318724ENST00000485614ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000318724ENST00000486180ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000419735ENST00000480514ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000419735ENST00000485614ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000419735ENST00000486180ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000478915ENST00000480514ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000478915ENST00000485614ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
In-frameENST00000478915ENST00000486180ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000388807ENST00000480514ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000388807ENST00000485614ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000388807ENST00000486180ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000472910ENST00000480514ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000472910ENST00000485614ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000472910ENST00000486180ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000477775ENST00000480514ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000477775ENST00000485614ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-3CDSENST00000477775ENST00000486180ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-5UTRENST00000388807ENST00000490493ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-5UTRENST00000472910ENST00000490493ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-5UTRENST00000477775ENST00000490493ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-intronENST00000388807ENST00000460135ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-intronENST00000472910ENST00000460135ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-
intron-intronENST00000477775ENST00000460135ATXN7L1chr7

105429050

-EFCAB10chr7

105210018

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000419735ATXN7L1chr7105429050-ENST00000480514EFCAB10chr7105210018-99840146678210
ENST00000419735ATXN7L1chr7105429050-ENST00000485614EFCAB10chr7105210018-106140146744232
ENST00000419735ATXN7L1chr7105429050-ENST00000486180EFCAB10chr7105210018-182240146690214
ENST00000318724ATXN7L1chr7105429050-ENST00000480514EFCAB10chr7105210018-97637924656210
ENST00000318724ATXN7L1chr7105429050-ENST00000485614EFCAB10chr7105210018-103937924722232
ENST00000318724ATXN7L1chr7105429050-ENST00000486180EFCAB10chr7105210018-180037924668214
ENST00000478915ATXN7L1chr7105429050-ENST00000480514EFCAB10chr7105210018-8022053482159
ENST00000478915ATXN7L1chr7105429050-ENST00000485614EFCAB10chr7105210018-8652053548181
ENST00000478915ATXN7L1chr7105429050-ENST00000486180EFCAB10chr7105210018-16262053494163

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000419735ENST00000480514ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0014088540.9985911
ENST00000419735ENST00000485614ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0010156120.9989844
ENST00000419735ENST00000486180ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0012143530.9987857
ENST00000318724ENST00000480514ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0009943510.9990056
ENST00000318724ENST00000485614ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0007317830.99926823
ENST00000318724ENST00000486180ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0010078830.99899215
ENST00000478915ENST00000480514ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0030378180.99696213
ENST00000478915ENST00000485614ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0013485420.99865144
ENST00000478915ENST00000486180ATXN7L1chr7105429050-EFCAB10chr7105210018-0.0041558170.9958442

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Fusion Genomic Features for ATXN7L1-EFCAB10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATXN7L1-EFCAB10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:105429050/chr7:105210018)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATXN7L1

Q9ULK2

EFCAB10

A6NFE3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEFCAB10chr7:105429050chr7:105210018ENST000004805140563_9835128.0DomainEF-hand

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000318724-34364_417118147.0Compositional biasNote=Ser-rich
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000318724-34536_847118147.0Compositional biasNote=Ser-rich
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000419735-312364_417118862.0Compositional biasNote=Ser-rich
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000419735-312536_847118862.0Compositional biasNote=Ser-rich
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000477775-110364_4170739.0Compositional biasNote=Ser-rich
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000477775-110536_8470739.0Compositional biasNote=Ser-rich
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000318724-34284_351118147.0DomainSCA7
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000419735-312284_351118862.0DomainSCA7
HgeneATXN7L1chr7:105429050chr7:105210018ENST00000477775-110284_3510739.0DomainSCA7


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Fusion Gene Sequence for ATXN7L1-EFCAB10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8453_8453_1_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000318724_EFCAB10_chr7_105210018_ENST00000480514_length(transcript)=976nt_BP=379nt
ACTCAATGTCGGAACGTTCCGAAGATGACGTCGGAGCGTTCTCGAATCCCGTGTCTCTCGGCTGCTGCTGCCGAAGGAACAGGGAAAAAG
CAACAAGAAGGAAGAGCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAAACCCTGGTCCTCCTGGATCGAC
GCCGCCAAATTACACTGCTCCGACAATGTAGATTTAGAAGAGGCTGGAAAAGAGGGTGGAAAAAGCAGGGAGGTTATGAGGCTTAATAAA
GAAGATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTGTAACCAGGTCGTCAAGCCACAG
GTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGCAAAAGTAACAGGCGTGGCGTTT
CCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCACCATATCATTTGTGCAGTATAAA
GAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAACTTTGGATAAATTCAAGGAGGAA
GTGAACAAGAGGATGAAGGAAATATGATGTATACATCCAGCTTCTCTACAAGCATTTGCCAGAAAATTTTAAATAAGGAGAAACAAAGCT
GCTGCTCCAACTGAAGTAAATGGTCTCGTAACGTCAGCAGCAACGGGCAAGCCGAACTGGACAGGGACATCACTGCCTGCTCTGACTGAG
ATGGCAAGGACAACCATCTGGAAAAAACACATTTTTACCAAAAAATTTTCATCAGTTTCTATTTTTCAAGTTTTTAAATCATTTTAAATT

>8453_8453_1_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000318724_EFCAB10_chr7_105210018_ENST00000480514_length(amino acids)=210AA_BP=0
MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNVDLEEAGKEGGKSREVMRLNKEDMHLFGH
YPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVAFPFFMDNSNIVAMFEMMDSSGRGTISFVQYKEALKTLGL

--------------------------------------------------------------
>8453_8453_2_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000318724_EFCAB10_chr7_105210018_ENST00000485614_length(transcript)=1039nt_BP=379nt
ACTCAATGTCGGAACGTTCCGAAGATGACGTCGGAGCGTTCTCGAATCCCGTGTCTCTCGGCTGCTGCTGCCGAAGGAACAGGGAAAAAG
CAACAAGAAGGAAGAGCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAAACCCTGGTCCTCCTGGATCGAC
GCCGCCAAATTACACTGCTCCGACAATGTAGATTTAGAAGAGGCTGGAAAAGAGGGTGGAAAAAGCAGGGAGGTTATGAGGCTTAATAAA
GAAGATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTGTAACCAGGTCGTCAAGCCACAG
GTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGCAAAAGTAACAGGCGTGGCGTTT
CCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCACCATATCATTTGTGCAGTATAAA
GAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAACTTTGGATAAATTCAAGGAGGAA
GTGAACAAGAGGATGAAGGAAATATGTGAGAAAACAAAGGGAAAAGATTCCGAGTCATATCAAACTGCAGCTGGGCTGCTCCTCCTTCAT
TGAAGTGATTAGCAAGAATTATCTGAAACAAAGAATAATTCATATAACAGTTGTCTTTATTATCACAGCCCAAAAACAGTCTATTCTTAC
TTACTTCTTGGTAGATGTATACATCCAGCTTCTCTACAAGCATTTGCCAGAAAATTTTAAATAAGGAGAAACAAAGCTGCTGCTCCAACT
GAAGTAAATGGTCTCGTAACGTCAGCAGCAACGGGCAAGCCGAACTGGACAGGGACATCACTGCCTGCTCTGACTGAGATGGCAAGGACA

>8453_8453_2_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000318724_EFCAB10_chr7_105210018_ENST00000485614_length(amino acids)=232AA_BP=0
MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNVDLEEAGKEGGKSREVMRLNKEDMHLFGH
YPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVAFPFFMDNSNIVAMFEMMDSSGRGTISFVQYKEALKTLGL

--------------------------------------------------------------
>8453_8453_3_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000318724_EFCAB10_chr7_105210018_ENST00000486180_length(transcript)=1800nt_BP=379nt
ACTCAATGTCGGAACGTTCCGAAGATGACGTCGGAGCGTTCTCGAATCCCGTGTCTCTCGGCTGCTGCTGCCGAAGGAACAGGGAAAAAG
CAACAAGAAGGAAGAGCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAAACCCTGGTCCTCCTGGATCGAC
GCCGCCAAATTACACTGCTCCGACAATGTAGATTTAGAAGAGGCTGGAAAAGAGGGTGGAAAAAGCAGGGAGGTTATGAGGCTTAATAAA
GAAGATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTGTAACCAGGTCGTCAAGCCACAG
GTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGCAAAAGTAACAGGCGTGGCGTTT
CCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCACCATATCATTTGTGCAGTATAAA
GAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAACTTTGGATAAATTCAAGGAGGAA
GTGAACAAGAGGATGAAGGAAATATGGTCAGCATTTTAATAACACCATAAATCCAAGATAATAAGTAATTCTATAAAGTTTTCCAGTTTC
ATTAATTCAGAATTTCATCATATAACTTGAAATCCAATTGGCTTCCTCTTTCTTAGAAACAAAAACCAAAGAAACCTTTTTCTGAAAGAC
ATTATTTTCCAGTATTAGGCCAATTTGTCCTCAAATTAAGTAGAATCTCAACATCTTGTTGAGCCAGTTTGTAAATTCCAACTTCATTTA
ATGCTGCTGTGGCAGGAAGCTGCCCTGAAGCTGACTGCAGTACATCTTTCAGCAGTAGTGCAGAACCGACGTTCAAATTCAAAACAATAC
AGGCTTCTTTTATACTGTTTAGGGAAAACAAAGGAGGGAAATGAGATCTCCATTATCTGCATCAATTATATTACAATTTTGAGAATCCTA
AACAGCTTCTCTGCACTGCTGGTCCACATGTTCTCTATAAAAATATTTATGGATTTATTATTTGGTTCTTTTAACATGGTAAGACTACAC
AGGTGCAGAGTTGCTATTTCTTTAGATTACTATAAGGTAATACGATCCCTATTTCAATATGTATCCGTTATTTCCCTAAATACAATACTT
AATATTAACACTATATTAAATATAGCTATAACTTTAGGTAGATTAGAACATGGGAAAAGACAAAAATAAGAGATAAATGAAAGCAGCAGA
AAGAACATTAAAATAAATTTTAAAAACAGTCCTATGAAACGTGTAAACATAAGCTTTCATTTTATAAGTCTAAAAGGAATGCTTTATAAC
CTCACAAAACCCAAACATAATTTAAATTTTACTTTTTTTTTTTGAGACATGGTCTTGCTCTGTCACCTAGGCTGGAGTGAAACTGCACGA
TCATAGCTCACTACAGCCTCAGCCTCTCAAGTAGCTAGGACTACAGGTCCACACCCCCACACCTGGCTTTTTTTTGTTTGTTCATTTTAA
TACTTTCTGTAGAGATGGAGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACAGCTGGCCTCAAGCAATTCTCCCACCTCTGCCTCCCAAA
GTACTGGGATTACAGATGTGGGCTACTATGCCTGGCCTATAAATTTTAGATCAACAAATTCTGAAACTATAATTATATTTAGAACCAAAA

>8453_8453_3_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000318724_EFCAB10_chr7_105210018_ENST00000486180_length(amino acids)=214AA_BP=0
MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNVDLEEAGKEGGKSREVMRLNKEDMHLFGH
YPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVAFPFFMDNSNIVAMFEMMDSSGRGTISFVQYKEALKTLGL

--------------------------------------------------------------
>8453_8453_4_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000419735_EFCAB10_chr7_105210018_ENST00000480514_length(transcript)=998nt_BP=401nt
CCCTCCCTCCCCCTTTCAGAACACTCAATGTCGGAACGTTCCGAAGATGACGTCGGAGCGTTCTCGAATCCCGTGTCTCTCGGCTGCTGC
TGCCGAAGGAACAGGGAAAAAGCAACAAGAAGGAAGAGCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAA
ACCCTGGTCCTCCTGGATCGACGCCGCCAAATTACACTGCTCCGACAATGTAGATTTAGAAGAGGCTGGAAAAGAGGGTGGAAAAAGCAG
GGAGGTTATGAGGCTTAATAAAGAAGATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTG
TAACCAGGTCGTCAAGCCACAGGTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGC
AAAAGTAACAGGCGTGGCGTTTCCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCAC
CATATCATTTGTGCAGTATAAAGAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAAC
TTTGGATAAATTCAAGGAGGAAGTGAACAAGAGGATGAAGGAAATATGATGTATACATCCAGCTTCTCTACAAGCATTTGCCAGAAAATT
TTAAATAAGGAGAAACAAAGCTGCTGCTCCAACTGAAGTAAATGGTCTCGTAACGTCAGCAGCAACGGGCAAGCCGAACTGGACAGGGAC
ATCACTGCCTGCTCTGACTGAGATGGCAAGGACAACCATCTGGAAAAAACACATTTTTACCAAAAAATTTTCATCAGTTTCTATTTTTCA
AGTTTTTAAATCATTTTAAATTTGAGGAAGTGTTCTGTCCTAGGGCATTTTGGATAAGAAAAAATATACAGCCTAACATTAAAAGCTCTA

>8453_8453_4_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000419735_EFCAB10_chr7_105210018_ENST00000480514_length(amino acids)=210AA_BP=0
MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNVDLEEAGKEGGKSREVMRLNKEDMHLFGH
YPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVAFPFFMDNSNIVAMFEMMDSSGRGTISFVQYKEALKTLGL

--------------------------------------------------------------
>8453_8453_5_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000419735_EFCAB10_chr7_105210018_ENST00000485614_length(transcript)=1061nt_BP=401nt
CCCTCCCTCCCCCTTTCAGAACACTCAATGTCGGAACGTTCCGAAGATGACGTCGGAGCGTTCTCGAATCCCGTGTCTCTCGGCTGCTGC
TGCCGAAGGAACAGGGAAAAAGCAACAAGAAGGAAGAGCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAA
ACCCTGGTCCTCCTGGATCGACGCCGCCAAATTACACTGCTCCGACAATGTAGATTTAGAAGAGGCTGGAAAAGAGGGTGGAAAAAGCAG
GGAGGTTATGAGGCTTAATAAAGAAGATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTG
TAACCAGGTCGTCAAGCCACAGGTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGC
AAAAGTAACAGGCGTGGCGTTTCCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCAC
CATATCATTTGTGCAGTATAAAGAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAAC
TTTGGATAAATTCAAGGAGGAAGTGAACAAGAGGATGAAGGAAATATGTGAGAAAACAAAGGGAAAAGATTCCGAGTCATATCAAACTGC
AGCTGGGCTGCTCCTCCTTCATTGAAGTGATTAGCAAGAATTATCTGAAACAAAGAATAATTCATATAACAGTTGTCTTTATTATCACAG
CCCAAAAACAGTCTATTCTTACTTACTTCTTGGTAGATGTATACATCCAGCTTCTCTACAAGCATTTGCCAGAAAATTTTAAATAAGGAG
AAACAAAGCTGCTGCTCCAACTGAAGTAAATGGTCTCGTAACGTCAGCAGCAACGGGCAAGCCGAACTGGACAGGGACATCACTGCCTGC

>8453_8453_5_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000419735_EFCAB10_chr7_105210018_ENST00000485614_length(amino acids)=232AA_BP=0
MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNVDLEEAGKEGGKSREVMRLNKEDMHLFGH
YPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVAFPFFMDNSNIVAMFEMMDSSGRGTISFVQYKEALKTLGL

--------------------------------------------------------------
>8453_8453_6_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000419735_EFCAB10_chr7_105210018_ENST00000486180_length(transcript)=1822nt_BP=401nt
CCCTCCCTCCCCCTTTCAGAACACTCAATGTCGGAACGTTCCGAAGATGACGTCGGAGCGTTCTCGAATCCCGTGTCTCTCGGCTGCTGC
TGCCGAAGGAACAGGGAAAAAGCAACAAGAAGGAAGAGCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAA
ACCCTGGTCCTCCTGGATCGACGCCGCCAAATTACACTGCTCCGACAATGTAGATTTAGAAGAGGCTGGAAAAGAGGGTGGAAAAAGCAG
GGAGGTTATGAGGCTTAATAAAGAAGATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTG
TAACCAGGTCGTCAAGCCACAGGTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGC
AAAAGTAACAGGCGTGGCGTTTCCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCAC
CATATCATTTGTGCAGTATAAAGAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAAC
TTTGGATAAATTCAAGGAGGAAGTGAACAAGAGGATGAAGGAAATATGGTCAGCATTTTAATAACACCATAAATCCAAGATAATAAGTAA
TTCTATAAAGTTTTCCAGTTTCATTAATTCAGAATTTCATCATATAACTTGAAATCCAATTGGCTTCCTCTTTCTTAGAAACAAAAACCA
AAGAAACCTTTTTCTGAAAGACATTATTTTCCAGTATTAGGCCAATTTGTCCTCAAATTAAGTAGAATCTCAACATCTTGTTGAGCCAGT
TTGTAAATTCCAACTTCATTTAATGCTGCTGTGGCAGGAAGCTGCCCTGAAGCTGACTGCAGTACATCTTTCAGCAGTAGTGCAGAACCG
ACGTTCAAATTCAAAACAATACAGGCTTCTTTTATACTGTTTAGGGAAAACAAAGGAGGGAAATGAGATCTCCATTATCTGCATCAATTA
TATTACAATTTTGAGAATCCTAAACAGCTTCTCTGCACTGCTGGTCCACATGTTCTCTATAAAAATATTTATGGATTTATTATTTGGTTC
TTTTAACATGGTAAGACTACACAGGTGCAGAGTTGCTATTTCTTTAGATTACTATAAGGTAATACGATCCCTATTTCAATATGTATCCGT
TATTTCCCTAAATACAATACTTAATATTAACACTATATTAAATATAGCTATAACTTTAGGTAGATTAGAACATGGGAAAAGACAAAAATA
AGAGATAAATGAAAGCAGCAGAAAGAACATTAAAATAAATTTTAAAAACAGTCCTATGAAACGTGTAAACATAAGCTTTCATTTTATAAG
TCTAAAAGGAATGCTTTATAACCTCACAAAACCCAAACATAATTTAAATTTTACTTTTTTTTTTTGAGACATGGTCTTGCTCTGTCACCT
AGGCTGGAGTGAAACTGCACGATCATAGCTCACTACAGCCTCAGCCTCTCAAGTAGCTAGGACTACAGGTCCACACCCCCACACCTGGCT
TTTTTTTGTTTGTTCATTTTAATACTTTCTGTAGAGATGGAGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACAGCTGGCCTCAAGCAAT
TCTCCCACCTCTGCCTCCCAAAGTACTGGGATTACAGATGTGGGCTACTATGCCTGGCCTATAAATTTTAGATCAACAAATTCTGAAACT

>8453_8453_6_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000419735_EFCAB10_chr7_105210018_ENST00000486180_length(amino acids)=214AA_BP=0
MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNVDLEEAGKEGGKSREVMRLNKEDMHLFGH
YPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVAFPFFMDNSNIVAMFEMMDSSGRGTISFVQYKEALKTLGL

--------------------------------------------------------------
>8453_8453_7_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000478915_EFCAB10_chr7_105210018_ENST00000480514_length(transcript)=802nt_BP=205nt
GCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAAACCCTGGTCCTCCTGGATCGACGCCGCCAAATTACAC
TGCTCCGACAATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTGTAACCAGGTCGTCAAG
CCACAGGTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGCAAAAGTAACAGGCGTG
GCGTTTCCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCACCATATCATTTGTGCAG
TATAAAGAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAACTTTGGATAAATTCAAG
GAGGAAGTGAACAAGAGGATGAAGGAAATATGATGTATACATCCAGCTTCTCTACAAGCATTTGCCAGAAAATTTTAAATAAGGAGAAAC
AAAGCTGCTGCTCCAACTGAAGTAAATGGTCTCGTAACGTCAGCAGCAACGGGCAAGCCGAACTGGACAGGGACATCACTGCCTGCTCTG
ACTGAGATGGCAAGGACAACCATCTGGAAAAAACACATTTTTACCAAAAAATTTTCATCAGTTTCTATTTTTCAAGTTTTTAAATCATTT

>8453_8453_7_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000478915_EFCAB10_chr7_105210018_ENST00000480514_length(amino acids)=159AA_BP=0
MATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVA

--------------------------------------------------------------
>8453_8453_8_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000478915_EFCAB10_chr7_105210018_ENST00000485614_length(transcript)=865nt_BP=205nt
GCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAAACCCTGGTCCTCCTGGATCGACGCCGCCAAATTACAC
TGCTCCGACAATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTGTAACCAGGTCGTCAAG
CCACAGGTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGCAAAAGTAACAGGCGTG
GCGTTTCCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCACCATATCATTTGTGCAG
TATAAAGAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAACTTTGGATAAATTCAAG
GAGGAAGTGAACAAGAGGATGAAGGAAATATGTGAGAAAACAAAGGGAAAAGATTCCGAGTCATATCAAACTGCAGCTGGGCTGCTCCTC
CTTCATTGAAGTGATTAGCAAGAATTATCTGAAACAAAGAATAATTCATATAACAGTTGTCTTTATTATCACAGCCCAAAAACAGTCTAT
TCTTACTTACTTCTTGGTAGATGTATACATCCAGCTTCTCTACAAGCATTTGCCAGAAAATTTTAAATAAGGAGAAACAAAGCTGCTGCT
CCAACTGAAGTAAATGGTCTCGTAACGTCAGCAGCAACGGGCAAGCCGAACTGGACAGGGACATCACTGCCTGCTCTGACTGAGATGGCA

>8453_8453_8_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000478915_EFCAB10_chr7_105210018_ENST00000485614_length(amino acids)=181AA_BP=0
MATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVA
FPFFMDNSNIVAMFEMMDSSGRGTISFVQYKEALKTLGLCTEDEDLQDDGHKITLDKFKEEVNKRMKEICEKTKGKDSESYQTAAGLLLL

--------------------------------------------------------------
>8453_8453_9_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000478915_EFCAB10_chr7_105210018_ENST00000486180_length(transcript)=1626nt_BP=205nt
GCAATGGCGACACTGGATCGCAAAGTGCCCAGTCCGGAGGCGTTTCTGGGCAAACCCTGGTCCTCCTGGATCGACGCCGCCAAATTACAC
TGCTCCGACAATATGCACTTATTTGGCCATTACCCAGCACATGACGACTTCTATCTCGTAGTGTGCAGTGCCTGTAACCAGGTCGTCAAG
CCACAGGTTTTCCAGTCGCACTGCGAAAAACCAAAAGAATATTTAATATCTCTATTGGAACGACTGAGAATTGCAAAAGTAACAGGCGTG
GCGTTTCCTTTCTTTATGGATAACTCTAACATTGTGGCTATGTTTGAGATGATGGACTCCTCAGGCAGAGGCACCATATCATTTGTGCAG
TATAAAGAAGCCCTAAAAACCCTGGGTCTATGCACTGAAGATGAAGATTTACAAGATGATGGACATAAAATAACTTTGGATAAATTCAAG
GAGGAAGTGAACAAGAGGATGAAGGAAATATGGTCAGCATTTTAATAACACCATAAATCCAAGATAATAAGTAATTCTATAAAGTTTTCC
AGTTTCATTAATTCAGAATTTCATCATATAACTTGAAATCCAATTGGCTTCCTCTTTCTTAGAAACAAAAACCAAAGAAACCTTTTTCTG
AAAGACATTATTTTCCAGTATTAGGCCAATTTGTCCTCAAATTAAGTAGAATCTCAACATCTTGTTGAGCCAGTTTGTAAATTCCAACTT
CATTTAATGCTGCTGTGGCAGGAAGCTGCCCTGAAGCTGACTGCAGTACATCTTTCAGCAGTAGTGCAGAACCGACGTTCAAATTCAAAA
CAATACAGGCTTCTTTTATACTGTTTAGGGAAAACAAAGGAGGGAAATGAGATCTCCATTATCTGCATCAATTATATTACAATTTTGAGA
ATCCTAAACAGCTTCTCTGCACTGCTGGTCCACATGTTCTCTATAAAAATATTTATGGATTTATTATTTGGTTCTTTTAACATGGTAAGA
CTACACAGGTGCAGAGTTGCTATTTCTTTAGATTACTATAAGGTAATACGATCCCTATTTCAATATGTATCCGTTATTTCCCTAAATACA
ATACTTAATATTAACACTATATTAAATATAGCTATAACTTTAGGTAGATTAGAACATGGGAAAAGACAAAAATAAGAGATAAATGAAAGC
AGCAGAAAGAACATTAAAATAAATTTTAAAAACAGTCCTATGAAACGTGTAAACATAAGCTTTCATTTTATAAGTCTAAAAGGAATGCTT
TATAACCTCACAAAACCCAAACATAATTTAAATTTTACTTTTTTTTTTTGAGACATGGTCTTGCTCTGTCACCTAGGCTGGAGTGAAACT
GCACGATCATAGCTCACTACAGCCTCAGCCTCTCAAGTAGCTAGGACTACAGGTCCACACCCCCACACCTGGCTTTTTTTTGTTTGTTCA
TTTTAATACTTTCTGTAGAGATGGAGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACAGCTGGCCTCAAGCAATTCTCCCACCTCTGCCT
CCCAAAGTACTGGGATTACAGATGTGGGCTACTATGCCTGGCCTATAAATTTTAGATCAACAAATTCTGAAACTATAATTATATTTAGAA

>8453_8453_9_ATXN7L1-EFCAB10_ATXN7L1_chr7_105429050_ENST00000478915_EFCAB10_chr7_105210018_ENST00000486180_length(amino acids)=163AA_BP=0
MATLDRKVPSPEAFLGKPWSSWIDAAKLHCSDNMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCEKPKEYLISLLERLRIAKVTGVA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATXN7L1-EFCAB10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATXN7L1-EFCAB10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATXN7L1-EFCAB10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource