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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SNRNP200-SDCCAG8 (FusionGDB2 ID:84719)

Fusion Gene Summary for SNRNP200-SDCCAG8

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRNP200-SDCCAG8
Fusion gene ID: 84719
HgeneTgene
Gene symbol

SNRNP200

SDCCAG8

Gene ID

23020

10806

Gene namesmall nuclear ribonucleoprotein U5 subunit 200SHH signaling and ciliogenesis regulator SDCCAG8
SynonymsASCC3L1|BRR2|HELIC2|RP33|U5-200KDBBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP
Cytomap

2q11.2

1q43-q44

Type of geneprotein-codingprotein-coding
DescriptionU5 small nuclear ribonucleoprotein 200 kDa helicaseBRR2 homologU5 snRNP-specific 200 kDa proteinactivating signal cointegrator 1 complex subunit 3-like 1bad response to refrigeration 2 homologsmall nuclear ribonucleoprotein 200kDa (U5)small nuclear serologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000323853, ENST00000349783, 
ENST00000391846, ENST00000496361, 
ENST00000343783, ENST00000355875, 
ENST00000366541, 
Fusion gene scores* DoF score12 X 12 X 5=72022 X 19 X 10=4180
# samples 1326
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4180*10)=-4.00691941393979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNRNP200 [Title/Abstract] AND SDCCAG8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSNRNP200(96950917)-SDCCAG8(243493841), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNRNP200

GO:0000398

mRNA splicing, via spliceosome

8670905|29301961


check buttonFusion gene breakpoints across SNRNP200 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SDCCAG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-R5-A7ZFSNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+


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Fusion Gene ORF analysis for SNRNP200-SDCCAG8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000323853ENST00000391846SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
5CDS-intronENST00000323853ENST00000496361SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
In-frameENST00000323853ENST00000343783SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
In-frameENST00000323853ENST00000355875SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
In-frameENST00000323853ENST00000366541SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
intron-3CDSENST00000349783ENST00000343783SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
intron-3CDSENST00000349783ENST00000355875SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
intron-3CDSENST00000349783ENST00000366541SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
intron-intronENST00000349783ENST00000391846SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+
intron-intronENST00000349783ENST00000496361SNRNP200chr2

96950917

-SDCCAG8chr1

243493841

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323853SNRNP200chr296950917-ENST00000355875SDCCAG8chr1243493841+561742427853151745
ENST00000323853SNRNP200chr296950917-ENST00000366541SDCCAG8chr1243493841+562342427853151745
ENST00000323853SNRNP200chr296950917-ENST00000343783SDCCAG8chr1243493841+562142427853151745

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323853ENST00000355875SNRNP200chr296950917-SDCCAG8chr1243493841+0.002957990.997042
ENST00000323853ENST00000366541SNRNP200chr296950917-SDCCAG8chr1243493841+0.0028848680.99711514
ENST00000323853ENST00000343783SNRNP200chr296950917-SDCCAG8chr1243493841+0.0028845380.9971155

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Fusion Genomic Features for SNRNP200-SDCCAG8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SNRNP200chr296950917-SDCCAG8chr1243493841+0.0029479410.9970521
SNRNP200chr296950917-SDCCAG8chr1243493841+0.0029479410.9970521

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SNRNP200-SDCCAG8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:96950917/chr1:243493841)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-304554_8413882137.0Coiled coilOntology_term=ECO:0000255
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-3045490_67313882137.0DomainHelicase ATP-binding 1
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-3045684_92113882137.0DomainHelicase C-terminal 1
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-3045981_128613882137.0DomainNote=SEC63 1
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-3045615_61813882137.0MotifNote=DEIH box
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-30451350_135713882137.0Nucleotide bindingATP
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-3045503_51013882137.0Nucleotide bindingATP
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000391846010129_1750361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000391846010223_2730361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000391846010348_7070361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000366541818534_692356714.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000391846010534_6920361.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000391846010216_7130361.0RegionSufficient for homodimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-30451337_151213882137.0DomainHelicase ATP-binding 2
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-30451545_175313882137.0DomainHelicase C-terminal 2
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-30451812_212413882137.0DomainNote=SEC63 2
HgeneSNRNP200chr2:96950917chr1:243493841ENST00000323853-30451454_145713882137.0MotifNote=DEVH box
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000366541818129_175356714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000366541818223_273356714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000366541818348_707356714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr2:96950917chr1:243493841ENST00000366541818216_713356714.0RegionSufficient for homodimerization


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Fusion Gene Sequence for SNRNP200-SDCCAG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84719_84719_1_SNRNP200-SDCCAG8_SNRNP200_chr2_96950917_ENST00000323853_SDCCAG8_chr1_243493841_ENST00000343783_length(transcript)=5621nt_BP=4242nt
CGGGAGCAGAGATCTGCGGCCGTTTGCAGCTTGCGGTAGGGAGGCGTGGTGGTCTGAAGCCTCCGAGCAGCCGCGGCCATGGCGGATGTA
ACCGCCCGTAGTCTGCAATACGAGTACAAGGCGAACTCGAATCTTGTGCTCCAAGCTGACCGTTCTCTCATTGACCGGACCCGCCGGGAT
GAACCCACAGGAGAGGTGCTGTCCCTTGTTGGGAAGCTGGAGGGCACCCGTATGGGAGACAAGGCTCAACGGACCAAACCGCAGATGCAG
GAGGAAAGAAGAGCCAAGCGAAGAAAGCGTGATGAGGACCGGCATGACATCAACAAGATGAAGGGTTATACTCTGCTGTCGGAGGGCATT
GATGAGATGGTGGGCATCATCTACAAGCCCAAAACTAAAGAGACTCGGGAGACCTATGAGGTGCTACTCAGCTTCATCCAGGCTGCTCTT
GGGGACCAGCCACGTGATATCCTTTGTGGGGCAGCTGATGAAGTTCTAGCTGTTCTAAAGAATGAAAAGCTGCGGGACAAGGAAAGGCGA
AAGGAGATTGACCTGCTGCTGGGTCAAACAGATGATACCAGATACCATGTGCTAGTGAACCTGGGCAAAAAGATCACAGACTATGGTGGA
GATAAGGAAATCCAAAATATGGATGACAACATTGATGAGACATACGGTGTGAATGTGCAGTTTGAGTCTGATGAGGAGGAAGGTGATGAA
GACGTATACGGGGAGGTTCGAGAAGAGGCATCTGATGATGACATGGAAGGGGACGAGGCTGTCGTGCGCTGCACCCTCTCGGCTAATCTC
GTAGCCTCAGGTGAACTGATGAGTTCCAAGAAGAAGGATTTGCACCCTCGGGATATTGATGCATTTTGGCTGCAGCGGCAGCTCAGTCGT
TTCTATGATGATGCCATCGTGTCGCAGAAGAAGGCAGATGAAGTATTGGAGATTTTGAAGACGGCCAGTGATGATCGGGAATGTGAAAAT
CAGCTGGTTCTGCTGCTTGGTTTCAACACCTTTGATTTCATTAAAGTGTTGCGGCAGCACAGGATGATGATTTTATACTGTACCTTGCTG
GCCAGTGCACAAAGTGAAGCTGAAAAGGAAAGGATTATGGGAAAGATGGAAGCTGACCCAGAGCTATCCAAGTTCCTCTACCAGCTTCAT
GAAACCGAGAAGGAGGATCTGATCCGAGAGGAAAGGTCCCGGAGAGAGCGAGTGCGTCAGTCTCGAATGGACACAGATCTGGAAACCATG
GATCTCGACCAGGGTGGAGAGGCACTGGCTCCACGGCAGGTTCTGGACTTGGAGGACCTGGTTTTTACCCAAGGGAGCCACTTTATGGCC
AATAAACGCTGTCAGCTTCCTGATGGATCCTTCCGTCGCCAGCGTAAGGGCTATGAAGAGGTGCATGTGCCTGCTCTGAAGCCCAAGCCC
TTTGGCTCAGAAGAACAACTGCTTCCAGTGGAAAAGCTGCCAAAGTATGCCCAGGCTGGGTTTGAGGGCTTCAAAACACTGAATCGGATC
CAGAGTAAGCTCTACCGTGCTGCCCTTGAGACGGATGAGAATCTGCTGCTGTGTGCTCCTACTGGTGCTGGGAAGACCAACGTGGCCCTG
ATGTGCATGCTCCGAGAGATTGGGAAACACATAAACATGGACGGCACCATCAATGTGGATGACTTCAAGATTATCTACATTGCCCCCATG
CGCTCCTTGGTGCAGGAGATGGTGGGCAGCTTTGGAAAGCGCCTGGCCACTTATGGCATCACTGTTGCTGAACTGACTGGGGACCACCAG
CTGTGCAAAGAAGAGATCAGTGCCACTCAGATCATCGTCTGCACCCCCGAGAAGTGGGACATCATCACCCGCAAGGGTGGTGAGCGCACC
TACACCCAGCTGGTGCGGCTCATCATTCTGGATGAGATTCATCTTCTCCACGATGACAGAGGTCCTGTCTTAGAAGCTTTAGTGGCCAGG
GCCATCCGAAACATTGAGATGACCCAAGAGGATGTCCGACTCATTGGTCTCAGTGCCACCCTACCCAACTATGAAGATGTAGCCACCTTT
CTACGTGTTGACCCTGCCAAGGGTCTCTTTTACTTTGACAACAGCTTCCGTCCAGTGCCTCTGGAACAGACATATGTGGGTATCACAGAG
AAAAAAGCTATCAAGCGTTTCCAGATCATGAATGAAATCGTCTATGAAAAAATCATGGAACATGCTGGAAAAAATCAGGTGCTGGTGTTT
GTCCACTCCCGGAAGGAGACTGGAAAGACAGCCAGGGCCATCCGGGACATGTGCCTAGAAAAGGACACTCTGGGTCTGTTTCTGAGGGAG
GGCTCAGCCTCCACAGAAGTCCTGCGAACAGAAGCTGAGCAGTGCAAGAACCTAGAGCTGAAGGATCTTCTGCCTTATGGCTTTGCTATT
CATCACGCAGGCATGACCAGGGTTGACCGAACACTCGTGGAGGATCTTTTTGCTGATAAACATATTCAGGTTTTAGTTTCCACAGCAACT
CTAGCTTGGGGTGTGAATCTCCCTGCACATACAGTCATCATCAAAGGCACCCAGGTGTACAGTCCAGAGAAGGGGCGTTGGACAGAACTG
GGAGCACTGGACATTCTGCAGATGCTGGGACGTGCCGGAAGACCCCAGTATGACACCAAGGGTGAAGGCATACTCATCACATCTCATGGG
GAGCTACAGTACTACCTGTCCCTCCTCAATCAACAACTTCCTATTGAAAGCCAGATGGTTTCAAAGCTTCCTGACATGCTCAATGCAGAA
ATCGTGCTAGGAAATGTCCAGAATGCCAAGGATGCGGTGAACTGGCTGGGCTATGCCTACCTCTATATCCGAATGCTGCGATCCCCAACC
CTCTATGGCATCTCTCATGATGACCTCAAGGGAGATCCCCTGCTGGACCAGCGCCGACTAGATCTGGTTCATACAGCTGCCCTGATGCTG
GACAAGAACAATCTGGTCAAGTACGACAAGAAGACGGGCAACTTCCAGGTGACAGAACTGGGCCGTATAGCCAGCCACTACTACATCACC
AATGATACAGTGCAGACTTACAACCAGCTGCTGAAGCCCACCCTGAGTGAGATTGAGCTTTTCAGGGTCTTCTCATTGTCCTCTGAGTTC
AAGAACATCACAGTGAGAGAGGAGGAGAAGCTGGAGCTGCAGAAGTTGCTGGAGAGGGTGCCTATCCCTGTAAAGGAGAGCATTGAGGAA
CCCAGTGCTAAGATCAACGTTCTTCTGCAAGCCTTCATCTCACAGCTGAAATTGGAGGGCTTTGCACTGATGGCTGACATGGTGTATGTC
ACACAGTCGGCTGGCCGGTTGATGCGAGCGATATTTGAAATTGTCCTGAACCGAGGTTGGGCACAGCTTACAGACAAGACCCTGAACCTC
TGCAAGATGATCGACAAACGCATGTGGCAGTCCATGTGTCCTCTGCGCCAGTTCCGGAAACTCCCTGAGGAAGTAGTGAAGAAGATTGAG
AAGAAGAATTTCCCCTTTGAGCGTCTGTACGACCTGAATCATAATGAGATTGGGGAGCTTATCCGCATGCCAAAGATGGGGAAGACCATC
CACAAATATGTCCATCTGTTTCCCAAGTTGGAGTTGTCAGTGCACCTGCAGCCTATCACACGCTCCACCCTGAAGGTGGAGCTGACCATC
ACGCCAGACTTCCAGTGGGATGAAAAGGTGCATGGTTCATCCGAGGCTTTTTGGATTCTGGTGGAGGATGTGGACAGCGAGGTGATTCTG
CACCATGAGTATTTTCTCCTCAAGGCCAAGTACGCCCAGGACGAGCACCTCATTACATTCTTCGTGCCTGTCTTTGAACCGCTGCCCCCT
CAGTACTTCATCCGAGTGGTGTCTGACCGCTGGCTCTCTTGTGAGACCCAGCTGCCTGTCTCCTTCCGGCACCTGATCTTGCCGGAGAAG
TACCCCCCTCCAACCGAACTTTTGGACCTGCAGCCCTTGCCCGTGTCTGCTCTGAGAAACAGTGCCTTTGAGAGTCTTTACCAAGATAAA
TTTCCTTTCTTCAATCCCATCCAGACCCAGGTGTTTAACACTGTATACAACAGTGACGACAACGTGTTTGTGGGGGCCCCCACGGGCAGC
GGGAAGACTATTTGTGCAGAGTTTGCCATCCTGCGAATGCTGCTGCAGAGCTCGGAGGGGCGCTGTGTGTACATCACCCCCATGGAGGCC
CTGGCAGAGCAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAG
CAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCT
CAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAG
CTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAA
AAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAA
AGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAG
CACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAA
AGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAG
AATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCT
CAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCAT
GGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGC
AAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGAT
TGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACC
ACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAG
CTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGC

>84719_84719_1_SNRNP200-SDCCAG8_SNRNP200_chr2_96950917_ENST00000323853_SDCCAG8_chr1_243493841_ENST00000343783_length(amino acids)=1745AA_BP=1387
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLL
SEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQR
QLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPAL
KPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEA
LVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLV
STATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASH
YYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKM
GKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGA
PTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKM
LILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRI
ELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLL
LTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLV

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>84719_84719_2_SNRNP200-SDCCAG8_SNRNP200_chr2_96950917_ENST00000323853_SDCCAG8_chr1_243493841_ENST00000355875_length(transcript)=5617nt_BP=4242nt
CGGGAGCAGAGATCTGCGGCCGTTTGCAGCTTGCGGTAGGGAGGCGTGGTGGTCTGAAGCCTCCGAGCAGCCGCGGCCATGGCGGATGTA
ACCGCCCGTAGTCTGCAATACGAGTACAAGGCGAACTCGAATCTTGTGCTCCAAGCTGACCGTTCTCTCATTGACCGGACCCGCCGGGAT
GAACCCACAGGAGAGGTGCTGTCCCTTGTTGGGAAGCTGGAGGGCACCCGTATGGGAGACAAGGCTCAACGGACCAAACCGCAGATGCAG
GAGGAAAGAAGAGCCAAGCGAAGAAAGCGTGATGAGGACCGGCATGACATCAACAAGATGAAGGGTTATACTCTGCTGTCGGAGGGCATT
GATGAGATGGTGGGCATCATCTACAAGCCCAAAACTAAAGAGACTCGGGAGACCTATGAGGTGCTACTCAGCTTCATCCAGGCTGCTCTT
GGGGACCAGCCACGTGATATCCTTTGTGGGGCAGCTGATGAAGTTCTAGCTGTTCTAAAGAATGAAAAGCTGCGGGACAAGGAAAGGCGA
AAGGAGATTGACCTGCTGCTGGGTCAAACAGATGATACCAGATACCATGTGCTAGTGAACCTGGGCAAAAAGATCACAGACTATGGTGGA
GATAAGGAAATCCAAAATATGGATGACAACATTGATGAGACATACGGTGTGAATGTGCAGTTTGAGTCTGATGAGGAGGAAGGTGATGAA
GACGTATACGGGGAGGTTCGAGAAGAGGCATCTGATGATGACATGGAAGGGGACGAGGCTGTCGTGCGCTGCACCCTCTCGGCTAATCTC
GTAGCCTCAGGTGAACTGATGAGTTCCAAGAAGAAGGATTTGCACCCTCGGGATATTGATGCATTTTGGCTGCAGCGGCAGCTCAGTCGT
TTCTATGATGATGCCATCGTGTCGCAGAAGAAGGCAGATGAAGTATTGGAGATTTTGAAGACGGCCAGTGATGATCGGGAATGTGAAAAT
CAGCTGGTTCTGCTGCTTGGTTTCAACACCTTTGATTTCATTAAAGTGTTGCGGCAGCACAGGATGATGATTTTATACTGTACCTTGCTG
GCCAGTGCACAAAGTGAAGCTGAAAAGGAAAGGATTATGGGAAAGATGGAAGCTGACCCAGAGCTATCCAAGTTCCTCTACCAGCTTCAT
GAAACCGAGAAGGAGGATCTGATCCGAGAGGAAAGGTCCCGGAGAGAGCGAGTGCGTCAGTCTCGAATGGACACAGATCTGGAAACCATG
GATCTCGACCAGGGTGGAGAGGCACTGGCTCCACGGCAGGTTCTGGACTTGGAGGACCTGGTTTTTACCCAAGGGAGCCACTTTATGGCC
AATAAACGCTGTCAGCTTCCTGATGGATCCTTCCGTCGCCAGCGTAAGGGCTATGAAGAGGTGCATGTGCCTGCTCTGAAGCCCAAGCCC
TTTGGCTCAGAAGAACAACTGCTTCCAGTGGAAAAGCTGCCAAAGTATGCCCAGGCTGGGTTTGAGGGCTTCAAAACACTGAATCGGATC
CAGAGTAAGCTCTACCGTGCTGCCCTTGAGACGGATGAGAATCTGCTGCTGTGTGCTCCTACTGGTGCTGGGAAGACCAACGTGGCCCTG
ATGTGCATGCTCCGAGAGATTGGGAAACACATAAACATGGACGGCACCATCAATGTGGATGACTTCAAGATTATCTACATTGCCCCCATG
CGCTCCTTGGTGCAGGAGATGGTGGGCAGCTTTGGAAAGCGCCTGGCCACTTATGGCATCACTGTTGCTGAACTGACTGGGGACCACCAG
CTGTGCAAAGAAGAGATCAGTGCCACTCAGATCATCGTCTGCACCCCCGAGAAGTGGGACATCATCACCCGCAAGGGTGGTGAGCGCACC
TACACCCAGCTGGTGCGGCTCATCATTCTGGATGAGATTCATCTTCTCCACGATGACAGAGGTCCTGTCTTAGAAGCTTTAGTGGCCAGG
GCCATCCGAAACATTGAGATGACCCAAGAGGATGTCCGACTCATTGGTCTCAGTGCCACCCTACCCAACTATGAAGATGTAGCCACCTTT
CTACGTGTTGACCCTGCCAAGGGTCTCTTTTACTTTGACAACAGCTTCCGTCCAGTGCCTCTGGAACAGACATATGTGGGTATCACAGAG
AAAAAAGCTATCAAGCGTTTCCAGATCATGAATGAAATCGTCTATGAAAAAATCATGGAACATGCTGGAAAAAATCAGGTGCTGGTGTTT
GTCCACTCCCGGAAGGAGACTGGAAAGACAGCCAGGGCCATCCGGGACATGTGCCTAGAAAAGGACACTCTGGGTCTGTTTCTGAGGGAG
GGCTCAGCCTCCACAGAAGTCCTGCGAACAGAAGCTGAGCAGTGCAAGAACCTAGAGCTGAAGGATCTTCTGCCTTATGGCTTTGCTATT
CATCACGCAGGCATGACCAGGGTTGACCGAACACTCGTGGAGGATCTTTTTGCTGATAAACATATTCAGGTTTTAGTTTCCACAGCAACT
CTAGCTTGGGGTGTGAATCTCCCTGCACATACAGTCATCATCAAAGGCACCCAGGTGTACAGTCCAGAGAAGGGGCGTTGGACAGAACTG
GGAGCACTGGACATTCTGCAGATGCTGGGACGTGCCGGAAGACCCCAGTATGACACCAAGGGTGAAGGCATACTCATCACATCTCATGGG
GAGCTACAGTACTACCTGTCCCTCCTCAATCAACAACTTCCTATTGAAAGCCAGATGGTTTCAAAGCTTCCTGACATGCTCAATGCAGAA
ATCGTGCTAGGAAATGTCCAGAATGCCAAGGATGCGGTGAACTGGCTGGGCTATGCCTACCTCTATATCCGAATGCTGCGATCCCCAACC
CTCTATGGCATCTCTCATGATGACCTCAAGGGAGATCCCCTGCTGGACCAGCGCCGACTAGATCTGGTTCATACAGCTGCCCTGATGCTG
GACAAGAACAATCTGGTCAAGTACGACAAGAAGACGGGCAACTTCCAGGTGACAGAACTGGGCCGTATAGCCAGCCACTACTACATCACC
AATGATACAGTGCAGACTTACAACCAGCTGCTGAAGCCCACCCTGAGTGAGATTGAGCTTTTCAGGGTCTTCTCATTGTCCTCTGAGTTC
AAGAACATCACAGTGAGAGAGGAGGAGAAGCTGGAGCTGCAGAAGTTGCTGGAGAGGGTGCCTATCCCTGTAAAGGAGAGCATTGAGGAA
CCCAGTGCTAAGATCAACGTTCTTCTGCAAGCCTTCATCTCACAGCTGAAATTGGAGGGCTTTGCACTGATGGCTGACATGGTGTATGTC
ACACAGTCGGCTGGCCGGTTGATGCGAGCGATATTTGAAATTGTCCTGAACCGAGGTTGGGCACAGCTTACAGACAAGACCCTGAACCTC
TGCAAGATGATCGACAAACGCATGTGGCAGTCCATGTGTCCTCTGCGCCAGTTCCGGAAACTCCCTGAGGAAGTAGTGAAGAAGATTGAG
AAGAAGAATTTCCCCTTTGAGCGTCTGTACGACCTGAATCATAATGAGATTGGGGAGCTTATCCGCATGCCAAAGATGGGGAAGACCATC
CACAAATATGTCCATCTGTTTCCCAAGTTGGAGTTGTCAGTGCACCTGCAGCCTATCACACGCTCCACCCTGAAGGTGGAGCTGACCATC
ACGCCAGACTTCCAGTGGGATGAAAAGGTGCATGGTTCATCCGAGGCTTTTTGGATTCTGGTGGAGGATGTGGACAGCGAGGTGATTCTG
CACCATGAGTATTTTCTCCTCAAGGCCAAGTACGCCCAGGACGAGCACCTCATTACATTCTTCGTGCCTGTCTTTGAACCGCTGCCCCCT
CAGTACTTCATCCGAGTGGTGTCTGACCGCTGGCTCTCTTGTGAGACCCAGCTGCCTGTCTCCTTCCGGCACCTGATCTTGCCGGAGAAG
TACCCCCCTCCAACCGAACTTTTGGACCTGCAGCCCTTGCCCGTGTCTGCTCTGAGAAACAGTGCCTTTGAGAGTCTTTACCAAGATAAA
TTTCCTTTCTTCAATCCCATCCAGACCCAGGTGTTTAACACTGTATACAACAGTGACGACAACGTGTTTGTGGGGGCCCCCACGGGCAGC
GGGAAGACTATTTGTGCAGAGTTTGCCATCCTGCGAATGCTGCTGCAGAGCTCGGAGGGGCGCTGTGTGTACATCACCCCCATGGAGGCC
CTGGCAGAGCAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAG
CAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCT
CAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAG
CTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAA
AAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAA
AGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAG
CACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAA
AGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAG
AATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCT
CAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCAT
GGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGC
AAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGAT
TGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACC
ACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAG
CTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGC

>84719_84719_2_SNRNP200-SDCCAG8_SNRNP200_chr2_96950917_ENST00000323853_SDCCAG8_chr1_243493841_ENST00000355875_length(amino acids)=1745AA_BP=1387
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLL
SEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQR
QLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPAL
KPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEA
LVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLV
STATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASH
YYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKM
GKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGA
PTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKM
LILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRI
ELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLL
LTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLV

--------------------------------------------------------------
>84719_84719_3_SNRNP200-SDCCAG8_SNRNP200_chr2_96950917_ENST00000323853_SDCCAG8_chr1_243493841_ENST00000366541_length(transcript)=5623nt_BP=4242nt
CGGGAGCAGAGATCTGCGGCCGTTTGCAGCTTGCGGTAGGGAGGCGTGGTGGTCTGAAGCCTCCGAGCAGCCGCGGCCATGGCGGATGTA
ACCGCCCGTAGTCTGCAATACGAGTACAAGGCGAACTCGAATCTTGTGCTCCAAGCTGACCGTTCTCTCATTGACCGGACCCGCCGGGAT
GAACCCACAGGAGAGGTGCTGTCCCTTGTTGGGAAGCTGGAGGGCACCCGTATGGGAGACAAGGCTCAACGGACCAAACCGCAGATGCAG
GAGGAAAGAAGAGCCAAGCGAAGAAAGCGTGATGAGGACCGGCATGACATCAACAAGATGAAGGGTTATACTCTGCTGTCGGAGGGCATT
GATGAGATGGTGGGCATCATCTACAAGCCCAAAACTAAAGAGACTCGGGAGACCTATGAGGTGCTACTCAGCTTCATCCAGGCTGCTCTT
GGGGACCAGCCACGTGATATCCTTTGTGGGGCAGCTGATGAAGTTCTAGCTGTTCTAAAGAATGAAAAGCTGCGGGACAAGGAAAGGCGA
AAGGAGATTGACCTGCTGCTGGGTCAAACAGATGATACCAGATACCATGTGCTAGTGAACCTGGGCAAAAAGATCACAGACTATGGTGGA
GATAAGGAAATCCAAAATATGGATGACAACATTGATGAGACATACGGTGTGAATGTGCAGTTTGAGTCTGATGAGGAGGAAGGTGATGAA
GACGTATACGGGGAGGTTCGAGAAGAGGCATCTGATGATGACATGGAAGGGGACGAGGCTGTCGTGCGCTGCACCCTCTCGGCTAATCTC
GTAGCCTCAGGTGAACTGATGAGTTCCAAGAAGAAGGATTTGCACCCTCGGGATATTGATGCATTTTGGCTGCAGCGGCAGCTCAGTCGT
TTCTATGATGATGCCATCGTGTCGCAGAAGAAGGCAGATGAAGTATTGGAGATTTTGAAGACGGCCAGTGATGATCGGGAATGTGAAAAT
CAGCTGGTTCTGCTGCTTGGTTTCAACACCTTTGATTTCATTAAAGTGTTGCGGCAGCACAGGATGATGATTTTATACTGTACCTTGCTG
GCCAGTGCACAAAGTGAAGCTGAAAAGGAAAGGATTATGGGAAAGATGGAAGCTGACCCAGAGCTATCCAAGTTCCTCTACCAGCTTCAT
GAAACCGAGAAGGAGGATCTGATCCGAGAGGAAAGGTCCCGGAGAGAGCGAGTGCGTCAGTCTCGAATGGACACAGATCTGGAAACCATG
GATCTCGACCAGGGTGGAGAGGCACTGGCTCCACGGCAGGTTCTGGACTTGGAGGACCTGGTTTTTACCCAAGGGAGCCACTTTATGGCC
AATAAACGCTGTCAGCTTCCTGATGGATCCTTCCGTCGCCAGCGTAAGGGCTATGAAGAGGTGCATGTGCCTGCTCTGAAGCCCAAGCCC
TTTGGCTCAGAAGAACAACTGCTTCCAGTGGAAAAGCTGCCAAAGTATGCCCAGGCTGGGTTTGAGGGCTTCAAAACACTGAATCGGATC
CAGAGTAAGCTCTACCGTGCTGCCCTTGAGACGGATGAGAATCTGCTGCTGTGTGCTCCTACTGGTGCTGGGAAGACCAACGTGGCCCTG
ATGTGCATGCTCCGAGAGATTGGGAAACACATAAACATGGACGGCACCATCAATGTGGATGACTTCAAGATTATCTACATTGCCCCCATG
CGCTCCTTGGTGCAGGAGATGGTGGGCAGCTTTGGAAAGCGCCTGGCCACTTATGGCATCACTGTTGCTGAACTGACTGGGGACCACCAG
CTGTGCAAAGAAGAGATCAGTGCCACTCAGATCATCGTCTGCACCCCCGAGAAGTGGGACATCATCACCCGCAAGGGTGGTGAGCGCACC
TACACCCAGCTGGTGCGGCTCATCATTCTGGATGAGATTCATCTTCTCCACGATGACAGAGGTCCTGTCTTAGAAGCTTTAGTGGCCAGG
GCCATCCGAAACATTGAGATGACCCAAGAGGATGTCCGACTCATTGGTCTCAGTGCCACCCTACCCAACTATGAAGATGTAGCCACCTTT
CTACGTGTTGACCCTGCCAAGGGTCTCTTTTACTTTGACAACAGCTTCCGTCCAGTGCCTCTGGAACAGACATATGTGGGTATCACAGAG
AAAAAAGCTATCAAGCGTTTCCAGATCATGAATGAAATCGTCTATGAAAAAATCATGGAACATGCTGGAAAAAATCAGGTGCTGGTGTTT
GTCCACTCCCGGAAGGAGACTGGAAAGACAGCCAGGGCCATCCGGGACATGTGCCTAGAAAAGGACACTCTGGGTCTGTTTCTGAGGGAG
GGCTCAGCCTCCACAGAAGTCCTGCGAACAGAAGCTGAGCAGTGCAAGAACCTAGAGCTGAAGGATCTTCTGCCTTATGGCTTTGCTATT
CATCACGCAGGCATGACCAGGGTTGACCGAACACTCGTGGAGGATCTTTTTGCTGATAAACATATTCAGGTTTTAGTTTCCACAGCAACT
CTAGCTTGGGGTGTGAATCTCCCTGCACATACAGTCATCATCAAAGGCACCCAGGTGTACAGTCCAGAGAAGGGGCGTTGGACAGAACTG
GGAGCACTGGACATTCTGCAGATGCTGGGACGTGCCGGAAGACCCCAGTATGACACCAAGGGTGAAGGCATACTCATCACATCTCATGGG
GAGCTACAGTACTACCTGTCCCTCCTCAATCAACAACTTCCTATTGAAAGCCAGATGGTTTCAAAGCTTCCTGACATGCTCAATGCAGAA
ATCGTGCTAGGAAATGTCCAGAATGCCAAGGATGCGGTGAACTGGCTGGGCTATGCCTACCTCTATATCCGAATGCTGCGATCCCCAACC
CTCTATGGCATCTCTCATGATGACCTCAAGGGAGATCCCCTGCTGGACCAGCGCCGACTAGATCTGGTTCATACAGCTGCCCTGATGCTG
GACAAGAACAATCTGGTCAAGTACGACAAGAAGACGGGCAACTTCCAGGTGACAGAACTGGGCCGTATAGCCAGCCACTACTACATCACC
AATGATACAGTGCAGACTTACAACCAGCTGCTGAAGCCCACCCTGAGTGAGATTGAGCTTTTCAGGGTCTTCTCATTGTCCTCTGAGTTC
AAGAACATCACAGTGAGAGAGGAGGAGAAGCTGGAGCTGCAGAAGTTGCTGGAGAGGGTGCCTATCCCTGTAAAGGAGAGCATTGAGGAA
CCCAGTGCTAAGATCAACGTTCTTCTGCAAGCCTTCATCTCACAGCTGAAATTGGAGGGCTTTGCACTGATGGCTGACATGGTGTATGTC
ACACAGTCGGCTGGCCGGTTGATGCGAGCGATATTTGAAATTGTCCTGAACCGAGGTTGGGCACAGCTTACAGACAAGACCCTGAACCTC
TGCAAGATGATCGACAAACGCATGTGGCAGTCCATGTGTCCTCTGCGCCAGTTCCGGAAACTCCCTGAGGAAGTAGTGAAGAAGATTGAG
AAGAAGAATTTCCCCTTTGAGCGTCTGTACGACCTGAATCATAATGAGATTGGGGAGCTTATCCGCATGCCAAAGATGGGGAAGACCATC
CACAAATATGTCCATCTGTTTCCCAAGTTGGAGTTGTCAGTGCACCTGCAGCCTATCACACGCTCCACCCTGAAGGTGGAGCTGACCATC
ACGCCAGACTTCCAGTGGGATGAAAAGGTGCATGGTTCATCCGAGGCTTTTTGGATTCTGGTGGAGGATGTGGACAGCGAGGTGATTCTG
CACCATGAGTATTTTCTCCTCAAGGCCAAGTACGCCCAGGACGAGCACCTCATTACATTCTTCGTGCCTGTCTTTGAACCGCTGCCCCCT
CAGTACTTCATCCGAGTGGTGTCTGACCGCTGGCTCTCTTGTGAGACCCAGCTGCCTGTCTCCTTCCGGCACCTGATCTTGCCGGAGAAG
TACCCCCCTCCAACCGAACTTTTGGACCTGCAGCCCTTGCCCGTGTCTGCTCTGAGAAACAGTGCCTTTGAGAGTCTTTACCAAGATAAA
TTTCCTTTCTTCAATCCCATCCAGACCCAGGTGTTTAACACTGTATACAACAGTGACGACAACGTGTTTGTGGGGGCCCCCACGGGCAGC
GGGAAGACTATTTGTGCAGAGTTTGCCATCCTGCGAATGCTGCTGCAGAGCTCGGAGGGGCGCTGTGTGTACATCACCCCCATGGAGGCC
CTGGCAGAGCAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAG
CAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCT
CAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAG
CTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAA
AAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAA
AGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAG
CACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAA
AGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAG
AATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCT
CAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCAT
GGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGC
AAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGAT
TGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACC
ACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAG
CTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGC

>84719_84719_3_SNRNP200-SDCCAG8_SNRNP200_chr2_96950917_ENST00000323853_SDCCAG8_chr1_243493841_ENST00000366541_length(amino acids)=1745AA_BP=1387
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLL
SEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQR
QLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPAL
KPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEA
LVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLV
STATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASH
YYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKM
GKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGA
PTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKM
LILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRI
ELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLL
LTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLV

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Fusion Gene PPI Analysis for SNRNP200-SDCCAG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SNRNP200-SDCCAG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SNRNP200-SDCCAG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource