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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AUNIP-MTFR1L (FusionGDB2 ID:8475)

Fusion Gene Summary for AUNIP-MTFR1L

check button Fusion gene summary
Fusion gene informationFusion gene name: AUNIP-MTFR1L
Fusion gene ID: 8475
HgeneTgene
Gene symbol

AUNIP

MTFR1L

Gene ID

79000

56181

Gene nameaurora kinase A and ninein interacting proteinmitochondrial fission regulator 1 like
SynonymsAIBP|C1orf135FAM54B|HYST1888|MST116|MSTP116
Cytomap

1p36.11

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionaurora kinase A and ninein-interacting proteinaurora A-binding proteinmitochondrial fission regulator 1-likefamily with sequence similarity 54 member Bprotein FAM54B
Modification date2020031320200313
UniProtAcc

Q9H7T9

Q9H019

Ensembl transtripts involved in fusion geneENST00000538789, ENST00000374298, 
ENST00000481602, 		ENST00000374300, 
ENST00000374301, ENST00000374303, 
ENST00000374307, ENST00000466284, 
ENST00000469815, ENST00000474295, 
ENST00000524618, ENST00000526894, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 6 X 2=60
# samples 36
** MAII scorelog2(3/8*10)=1.90689059560852log2(6/60*10)=0
Context

PubMed: AUNIP [Title/Abstract] AND MTFR1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAUNIP(26158412)-MTFR1L(26158628), # samples:1
AUNIP(26158412)-MTFR1L(26158481), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAUNIP

GO:0000724

double-strand break repair via homologous recombination

29042561

HgeneAUNIP

GO:2001033

negative regulation of double-strand break repair via nonhomologous end joining

29042561


check buttonFusion gene breakpoints across AUNIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTFR1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW948901AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
ChiTaRS5.0N/ABE768339AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-


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Fusion Gene ORF analysis for AUNIP-MTFR1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000538789ENST00000374300AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-3UTRENST00000538789ENST00000374301AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-3UTRENST00000538789ENST00000374303AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-3UTRENST00000538789ENST00000374307AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-3UTRENST00000538789ENST00000466284AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-3UTRENST00000538789ENST00000466284AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
5CDS-3UTRENST00000538789ENST00000469815AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-3UTRENST00000538789ENST00000469815AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
5CDS-3UTRENST00000538789ENST00000474295AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-3UTRENST00000538789ENST00000474295AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
5CDS-3UTRENST00000538789ENST00000524618AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-intronENST00000538789ENST00000374300AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
5CDS-intronENST00000538789ENST00000374301AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
5CDS-intronENST00000538789ENST00000374307AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
5CDS-intronENST00000538789ENST00000524618AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
5CDS-intronENST00000538789ENST00000526894AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
5CDS-intronENST00000538789ENST00000526894AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
In-frameENST00000538789ENST00000374303AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3CDSENST00000374298ENST00000374303AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3CDSENST00000481602ENST00000374303AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3UTRENST00000374298ENST00000374300AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000374298ENST00000374301AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000374298ENST00000374303AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000374298ENST00000374307AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000374298ENST00000466284AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000374298ENST00000466284AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3UTRENST00000374298ENST00000469815AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000374298ENST00000469815AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3UTRENST00000374298ENST00000474295AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000374298ENST00000474295AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3UTRENST00000374298ENST00000524618AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000374300AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000374301AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000374303AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000374307AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000466284AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000466284AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3UTRENST00000481602ENST00000469815AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000469815AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3UTRENST00000481602ENST00000474295AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-3UTRENST00000481602ENST00000474295AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-3UTRENST00000481602ENST00000524618AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-intronENST00000374298ENST00000374300AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000374298ENST00000374301AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000374298ENST00000374307AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000374298ENST00000524618AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000374298ENST00000526894AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-intronENST00000374298ENST00000526894AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000481602ENST00000374300AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000481602ENST00000374301AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000481602ENST00000374307AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000481602ENST00000524618AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-
intron-intronENST00000481602ENST00000526894AUNIPchr1

26158412

-MTFR1Lchr1

26158628

-
intron-intronENST00000481602ENST00000526894AUNIPchr1

26158412

-MTFR1Lchr1

26158481

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AUNIP-MTFR1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AUNIP-MTFR1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:26158412/chr1:26158628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AUNIP

Q9H7T9

MTFR1L

Q9H019

FUNCTION: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670). {ECO:0000269|PubMed:20596670, ECO:0000269|PubMed:29042561}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AUNIP-MTFR1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AUNIP-MTFR1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneAUNIPchr1:26158412chr1:26158481ENST00000538789-44187_357427.0372.0AURKA
HgeneAUNIPchr1:26158412chr1:26158481ENST00000538789-44281_357427.0372.0RBBP8/CtIP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAUNIPchr1:26158412chr1:26158481ENST00000374298-13187_3570358.0AURKA
HgeneAUNIPchr1:26158412chr1:26158481ENST00000374298-13281_3570358.0RBBP8/CtIP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AUNIP-MTFR1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AUNIP-MTFR1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource