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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SNRPA1-PHRF1 (FusionGDB2 ID:84753)

Fusion Gene Summary for SNRPA1-PHRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRPA1-PHRF1
Fusion gene ID: 84753
HgeneTgene
Gene symbol

SNRPA1

PHRF1

Gene ID

6627

57661

Gene namesmall nuclear ribonucleoprotein polypeptide A'PHD and ring finger domains 1
SynonymsLea1|U2A'PPP1R125|RNF221
Cytomap

15q26.3

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionU2 small nuclear ribonucleoprotein A'U2 small nuclear ribonucleoprotein polypeptide A'U2 snRNP A'PHD and RING finger domain-containing protein 1CTD-binding SR-like protein rA9protein phosphatase 1, regulatory subunit 125
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000560856, ENST00000254193, 
ENST00000264555, ENST00000413872, 
ENST00000416188, ENST00000533464, 
Fusion gene scores* DoF score4 X 2 X 2=164 X 5 X 4=80
# samples 44
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNRPA1 [Title/Abstract] AND PHRF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSNRPA1(101832167)-PHRF1(601574), # samples:2
Anticipated loss of major functional domain due to fusion event.SNRPA1-PHRF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SNRPA1-PHRF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNRPA1

GO:0000398

mRNA splicing, via spliceosome

28076346|28781166


check buttonFusion gene breakpoints across SNRPA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHRF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08G-01ASNRPA1chr15

101832167

-PHRF1chr11

601574

+
ChimerDB4BRCATCGA-A8-A08G-01ASNRPA1chr15

101832167

-PHRF1chr11

605119

+


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Fusion Gene ORF analysis for SNRPA1-PHRF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000560856ENST00000264555SNRPA1chr15

101832167

-PHRF1chr11

601574

+
5UTR-3CDSENST00000560856ENST00000264555SNRPA1chr15

101832167

-PHRF1chr11

605119

+
5UTR-3CDSENST00000560856ENST00000413872SNRPA1chr15

101832167

-PHRF1chr11

601574

+
5UTR-3CDSENST00000560856ENST00000413872SNRPA1chr15

101832167

-PHRF1chr11

605119

+
5UTR-3CDSENST00000560856ENST00000416188SNRPA1chr15

101832167

-PHRF1chr11

601574

+
5UTR-3CDSENST00000560856ENST00000416188SNRPA1chr15

101832167

-PHRF1chr11

605119

+
5UTR-3CDSENST00000560856ENST00000533464SNRPA1chr15

101832167

-PHRF1chr11

601574

+
5UTR-3CDSENST00000560856ENST00000533464SNRPA1chr15

101832167

-PHRF1chr11

605119

+
Frame-shiftENST00000254193ENST00000264555SNRPA1chr15

101832167

-PHRF1chr11

601574

+
Frame-shiftENST00000254193ENST00000413872SNRPA1chr15

101832167

-PHRF1chr11

601574

+
Frame-shiftENST00000254193ENST00000416188SNRPA1chr15

101832167

-PHRF1chr11

601574

+
Frame-shiftENST00000254193ENST00000533464SNRPA1chr15

101832167

-PHRF1chr11

601574

+
In-frameENST00000254193ENST00000264555SNRPA1chr15

101832167

-PHRF1chr11

605119

+
In-frameENST00000254193ENST00000413872SNRPA1chr15

101832167

-PHRF1chr11

605119

+
In-frameENST00000254193ENST00000416188SNRPA1chr15

101832167

-PHRF1chr11

605119

+
In-frameENST00000254193ENST00000533464SNRPA1chr15

101832167

-PHRF1chr11

605119

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254193SNRPA1chr15101832167-ENST00000264555PHRF1chr11605119+46253827341791368
ENST00000254193SNRPA1chr15101832167-ENST00000413872PHRF1chr11605119+43643827341761367
ENST00000254193SNRPA1chr15101832167-ENST00000533464PHRF1chr11605119+43673827341791368
ENST00000254193SNRPA1chr15101832167-ENST00000416188PHRF1chr11605119+43643827341761367

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254193ENST00000264555SNRPA1chr15101832167-PHRF1chr11605119+0.00861530.99138474
ENST00000254193ENST00000413872SNRPA1chr15101832167-PHRF1chr11605119+0.0113136740.9886863
ENST00000254193ENST00000533464SNRPA1chr15101832167-PHRF1chr11605119+0.0114827260.9885173
ENST00000254193ENST00000416188SNRPA1chr15101832167-PHRF1chr11605119+0.0113136740.9886863

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Fusion Genomic Features for SNRPA1-PHRF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SNRPA1chr15101832166-PHRF1chr11601573+8.68E-060.9999913
SNRPA1chr15101832166-PHRF1chr11605118+9.25E-101
SNRPA1chr15101832166-PHRF1chr11601573+8.68E-060.9999913
SNRPA1chr15101832166-PHRF1chr11605118+9.25E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SNRPA1-PHRF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:101832167/chr11:601574)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNRPA1chr15:101832167chr11:605119ENST00000254193-3920_41103256.0RepeatNote=LRR 1
HgeneSNRPA1chr15:101832167chr11:605119ENST00000254193-3943_64103256.0RepeatNote=LRR 2
HgeneSNRPA1chr15:101832167chr11:605119ENST00000254193-3965_86103256.0RepeatNote=LRR 3
TgenePHRF1chr15:101832167chr11:605119ENST000002645559181549_15793841650.0Coiled coilOntology_term=ECO:0000255
TgenePHRF1chr15:101832167chr11:605119ENST000004161889181549_15793841649.0Coiled coilOntology_term=ECO:0000255
TgenePHRF1chr15:101832167chr11:605119ENST00000264555918983_11813841650.0Compositional biasNote=Arg-rich
TgenePHRF1chr15:101832167chr11:605119ENST00000416188918983_11813841649.0Compositional biasNote=Arg-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNRPA1chr15:101832167chr11:605119ENST00000254193-39123_161103256.0DomainNote=LRRCT
HgeneSNRPA1chr15:101832167chr11:605119ENST00000254193-3989_110103256.0RepeatNote=LRR 4
TgenePHRF1chr15:101832167chr11:605119ENST00000264555918178_1813841650.0Compositional biasNote=Poly-Glu
TgenePHRF1chr15:101832167chr11:605119ENST00000264555918262_4013841650.0Compositional biasNote=Arg-rich
TgenePHRF1chr15:101832167chr11:605119ENST00000416188918178_1813841649.0Compositional biasNote=Poly-Glu
TgenePHRF1chr15:101832167chr11:605119ENST00000416188918262_4013841649.0Compositional biasNote=Arg-rich
TgenePHRF1chr15:101832167chr11:605119ENST00000264555918108_1493841650.0Zinc fingerRING-type%3B degenerate
TgenePHRF1chr15:101832167chr11:605119ENST00000264555918183_2333841650.0Zinc fingerPHD-type
TgenePHRF1chr15:101832167chr11:605119ENST00000416188918108_1493841649.0Zinc fingerRING-type%3B degenerate
TgenePHRF1chr15:101832167chr11:605119ENST00000416188918183_2333841649.0Zinc fingerPHD-type


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Fusion Gene Sequence for SNRPA1-PHRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84753_84753_1_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000264555_length(transcript)=4625nt_BP=382nt
GGGGCACGCTGGGACGTCTCGCTGGCGGGAGGCCACGGGCTTTCCACAGCGCGGGGGAACGGGAGGCTGCAGGATGGTCAAGCTGACGGC
GGAGCTGATCGAGCAGGCGGCGCAGTACACCAACGCGGTGCGCGACCGGGAGCTGGACCTCCGGGGGTATAAAATTCCCGTCATTGAAAA
TCTAGGTGCTACGTTAGACCAGTTTGATGCTATTGATTTTTCTGACAATGAGATCAGGAAACTGGATGGTTTTCCTTTGTTGAGAAGACT
GAAAACATTGTTAGTGAACAACAACAGAATATGCCGTATAGGTGAGGGACTTGATCAGGCTCTGCCCTGTCTGACAGAACTCATTCTCAC
CAATAATAGTCTCGTGGAACTGAGTGAAGCCACCACTCGCTCTCGAATCGCGCGGACGCTGGGCCTGCGCAGGCCTGTTCACAGCAGCTG
CATCCCGTCAGTGTTGAAGCCAGTGGAGCCCTCTTTGGGGCTGCTGAGAGCGGATATTGGAGCTGCCTCTCTGTCTCTGTTTGGAGATCC
TTATGAGCTGGATCCCTTCGACAGCAGTGAAGAGCTTTCTGCAAACCCTCTTTCCCCTCTGAGTGCCAAGAGACGGGCTCTGTCCCGGTC
AGCCCTGCAGTCCCACCAGCCCGTGGCCAGGCCCGTCTCCGTGGGGCTTTCCAGGAGGCGCCTCCCTGCCGCGGTGCCAGAGCCAGACTT
GGAGGAGGAGCCAGTGCCTGACCTGCTGGGCAGCATCCTGTCGGGCCAGAGCCTCCTGATGCTGGGCAGCAGTGATGTCATCATCCACCG
CGACGGCTCCCTCAGCGCCAAGAGGGCGGCTCCAGTTTCTTTTCAGCGAAACTCAGGCAGTCTGTCCAGAGGGGAAGAAGGATTCAAGGG
CTGCCTGCAGCCCCGAGCACTGCCCTCCGGGAGCCCGGCCCAAGGCCCGTCAGGAAACAGGCCACAGAGCACAGGGCTCAGCTGTCAAGG
CAGGTCCCGCACCCCCGCCCGCACCGCGGGGGCGCCTGTGAGGCTGGACTTGCCAGCAGCCCCTGGGGCGGTTCAGGCTCGGAACTTGTC
AAATGGGAGTGTGCCTGGCTTCAGACAGAGCCACAGCCCCTGGTTCAACGGCACCAACAAGCACACCTTGCCCCTTGCCTCTGCCGCGTC
TAAGATCTCAAGCAGAGATTCTAAGCCCCCATGTCGCAGTGTGGTGCCGGGGCCTCCCCTGAAGCCAGCGCCCAGAAGAACAGACATCTC
TGAGCTACCCAGGATACCAAAGATCAGGAGAGATGACGGTGGTGGCAGACGGGATGCGGCCCCGGCCCACGGGCAGAGCATTGAGATCCC
CAGTGCCTGCATCAGCCGACTGACTGGCAGGGAGGGCACCGGGCAGCCAGGGCGAGGCACACGGGCAGAGAGCGAGGCCAGCAGCAGGGT
GCCCCGGGAGCCCGGGGTGCACACGGGCAGCTCCCGGCCCCCAGCCCCCAGCTCCCATGGCAGTTTGGCCCCACTGGGACCATCAAGAGG
GAAAGGGGTCGGGTCGACCTTTGAGAGCTTCCGGATCAATATTCCTGGAAACATGGCACATTCCAGCCAGCTCTCCAGCCCTGGCTTCTG
TAACACGTTCCGGCCTGTGGACGATAAGGAGCAGAGGAAGGAGAACCCCTCACCCCTCTTCTCCATCAAGAAGACGAAGCAGCTGCGGAG
CGAGGTCTACGACCCATCCGACCCCACCGGCTCCGACTCCAGCGCCCCTGGCAGCAGCCCCGAGAGGTCTGGCCCCGGCCTCCTGCCCTC
TGAGATCACACGAACCATCTCCATCAACAGCCCGAAGGCCCAGACGGTGCAGGCTGTGCGCTGCGTCACCTCCTACACGGTGGAGAGCAT
CTTTGGTACAGAGCCCGAACCCCCTCTCGGACCGTCCTCCGCCATGTCCAAGCTCCGGGGTGCAGTGGCTGCCGAGGGGGCCTCTGACAC
GGAGCGAGAGGAGCCCACAGAGAGCCAGGGCCTGGCTGCCCGGCTGCGGAGGCCATCCCCCCCAGAGCCCTGGGATGAGGAGGATGGGGC
GTCTTGCAGCACCTTCTTTGGCTCTGAGGAGCGGACGGTGACCTGTGTGACTGTCGTGGAGCCGGAAGCCCCACCCAGCCCGGACGTGCT
GCAGGCTGCCACCCACAGAGTCGTGGAGCTCAGGCCCCCTTCCCGGTCCCGCTCCACATCCAGCTCCCGCAGCAGGAAGAAGGCCAAGAG
GAAGAGGGTGTCCAGGGAGCACGGACGGACGCGCTCTGGGACGCGCTCTGAATCCAGGGACAGGAGCTCGAGGTCAGCGTCACCATCAGT
GGGTGAGGAGCGCCCCAGGAGGCAGCGGTCCAAGGCCAAGAGCCGGCGGTCCTCCAGTGACCGCTCCAGCAGCCGAGAGCGAGCTAAGAG
GAAGAAAGCCAAGGACAAGAGCAGGGAGCACAGGCGGGGCCCCTGGGGCCACAGCCGGAGGACGTCCCGGTCGCGGTCGGGGAGCCCTGG
CAGCTCTTCCTATGAGCACTATGAGAGTAGGAAGAAGAAGAAAAGGAGATCAGCGTCCAGACCTCGGGGAAGGGAGTGCTCCCCCACCAG
CAGCCTGGAGAGGCTCTGCAGGCACAAGCATCAGCGGGAACGCAGCCACGAGCGGCCAGACAGGAAGGAGAGTGTGGCGTGGCCCCGAGA
CCGGAGGAAGCGGAGGTCCCGGTCCCCAAGCTCGGAGCACAGGGCACGGGAGCACAGGCGGCCTCGGTCCCGTGAGAAGTGGCCGCAGAC
CCGGTCCCATTCCCCAGAGAGGAAGGGGGCTGTGAGGGAGGCTTCCCCAGCGCCCCTTGCACAGGGGGAGCCAGGGCGGGAAGACCTCCC
CACCAGGTTGCCAGCCTTGGGGGAAGCACATGTCTCGCCGGAGGTGGCTACGGCCGACAAGGCCCCCCTGCAGGCTCCCCCTGTCCTGGA
GGTGGCAGCTGAGTGTGAGCCGGACGACCTGGACCTGGATTATGGCGACTCCGTGGAGGCCGGACACGTCTTTGATGATTTCTCAAGCGA
CGCCGTTTTCATCCAGCTCGATGACATGAGCTCGCCACCTTCTCCCGAAAGCACAGACTCTTCCCCGGAGCGAGACTTCCCACTGAAGCC
TGCGTTGCCCCCAGCCAGCCTGGCCGTGGCCGCCATCCAGAGGGAGGTGTCATTGATGCACGATGAAGACCCTTCGCAGCCCCCACCCCT
GCCAGAGGGCACCCAGGAGCCACATTTGCTCAGGCCGGACGCGGCTGAGAAGGCTGAGGCACCCAGTTCCCCGGATGTGGCGCCTGCGGG
GAAGGAAGACAGCCCCTCTGCGAGTGGGAGGGTACAGGAGGCAGCCCGGCCTGAGGAGGTGGTTTCGCAGACCCCCCTGCTGCGGTCCAG
AGCCCTGGTGAAGCGGGTCACCTGGAACCTGCAGGAGTCGGAGAGCAGCGCCCCCGCCGAGGACAGAGCCCCCCGGGCACCACTTCACAG
GCCACAGAAGCCCCGAGAAGGAGCCTGGGACATGGAGGATGTGGCCCCCACAGGGGTCAGGCAGGTGTTCTCCGAGCTGCCCTTTCCCAG
TCACGTGCTTCCGGAACCCGGGTTCCCAGACACAGACCCCTCTCAGGTTTACAGCCCCGGCCTGCCGCCTGCCCCGGCCCAGCCCTCAAG
CATCCCACCCTGCGCACTGGTCAGCCAGCCCACGGTCCAGTTCATCCTTCAGGGGAGCCTGCCGCTAGTGGGCTGTGGGGCAGCACAGAC
CCTGGCCCCAGTGCCCGCTGCCCTGACCCCAGCCTCAGAGCCAGCCAGTCAAGCCACTGCAGCCAGCAACTCGGAGGAGAAGACCCCGGC
CCCCAGGCTAGCTGCGGAGAAAACCAAGAAGGAGGAGTACATGAAGAAGCTGCACATGCAGGAGCGTGCTGTGGAGGAGGTGAAGCTGGC
CATCAAGCCCTTCTACCAGAAGAGGGAGGTGACCAAGGAGGAGTACAAGGACATCCTGCGCAAGGCCGTGCAGAAGATCTGCCACAGCAA
GAGTGGAGAGATCAACCCCGTGAAGGTGGCCAACCTGGTGAAGGCGTACGTGGACAAGTACAGGCACATGCGCAGGCACAAGAAACCAGA
GGCCGGGGAGGAGCCGCCCACGCAGGGGGCCGAGGGCTGAGGCCAGGCAATCACGGGCTATGCCCGGGGAGCTGTCGGGAGTGGCGGGAA
TCGGGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAATCGGGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAAATGGGGGGCATC
ACCATGCCTGCCGTCGGGTTCCTGCGCTGACACCTGGTCTGTGCACCTGTGTTGCTCACAGTTGAAAACTGGACACTTTTGTATGTATAT
TATAGAGACACTGTTTCCATTCTAATTTATCAAAAATGGATTATCTTTAGAAACCTCTTGATTGACTTACTACTTGGAAGATAAAGCACT
TGGTGATCAAGAGGGGCTCCTGGTGGGGTGGCGCGTCCTTGATAAATCTCTAGGTGGCCTCCCGCCAACAGCTGCTGTGTACCTTTGGCT

>84753_84753_1_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000264555_length(amino acids)=1368AA_BP=103
MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCL
TELILTNNSLVELSEATTRSRIARTLGLRRPVHSSCIPSVLKPVEPSLGLLRADIGAASLSLFGDPYELDPFDSSEELSANPLSPLSAKR
RALSRSALQSHQPVARPVSVGLSRRRLPAAVPEPDLEEEPVPDLLGSILSGQSLLMLGSSDVIIHRDGSLSAKRAAPVSFQRNSGSLSRG
EEGFKGCLQPRALPSGSPAQGPSGNRPQSTGLSCQGRSRTPARTAGAPVRLDLPAAPGAVQARNLSNGSVPGFRQSHSPWFNGTNKHTLP
LASAASKISSRDSKPPCRSVVPGPPLKPAPRRTDISELPRIPKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGTGQPGRGTRAES
EASSRVPREPGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCNTFRPVDDKEQRKENPSPLFSIKK
TKQLRSEVYDPSDPTGSDSSAPGSSPERSGPGLLPSEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAVAA
EGASDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPPSPDVLQAATHRVVELRPPSRSRSTSSSRS
RKKAKRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRS
RSGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQRERSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSR
EKWPQTRSHSPERKGAVREASPAPLAQGEPGREDLPTRLPALGEAHVSPEVATADKAPLQAPPVLEVAAECEPDDLDLDYGDSVEAGHVF
DDFSSDAVFIQLDDMSSPPSPESTDSSPERDFPLKPALPPASLAVAAIQREVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSP
DVAPAGKEDSPSASGRVQEAARPEEVVSQTPLLRSRALVKRVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFS
ELPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALVSQPTVQFILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNS
EEKTPAPRLAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQKICHSKSGEINPVKVANLVKAYVDKYRHMR

--------------------------------------------------------------
>84753_84753_2_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000413872_length(transcript)=4364nt_BP=382nt
GGGGCACGCTGGGACGTCTCGCTGGCGGGAGGCCACGGGCTTTCCACAGCGCGGGGGAACGGGAGGCTGCAGGATGGTCAAGCTGACGGC
GGAGCTGATCGAGCAGGCGGCGCAGTACACCAACGCGGTGCGCGACCGGGAGCTGGACCTCCGGGGGTATAAAATTCCCGTCATTGAAAA
TCTAGGTGCTACGTTAGACCAGTTTGATGCTATTGATTTTTCTGACAATGAGATCAGGAAACTGGATGGTTTTCCTTTGTTGAGAAGACT
GAAAACATTGTTAGTGAACAACAACAGAATATGCCGTATAGGTGAGGGACTTGATCAGGCTCTGCCCTGTCTGACAGAACTCATTCTCAC
CAATAATAGTCTCGTGGAACTGAGTGAAGCCACCACTCGCTCTCGAATCGCGCGGACGCTGGGCCTGCGCAGGCCTGTTCACAGCAGCTG
CATCCCGTCAGTGTTGAAGCCAGTGGAGCCCTCTTTGGGGCTGCTGAGAGCGGATATTGGAGCTGCCTCTCTGTCTCTGTTTGGAGATCC
TTATGAGCTGGATCCCTTCGACAGTGAAGAGCTTTCTGCAAACCCTCTTTCCCCTCTGAGTGCCAAGAGACGGGCTCTGTCCCGGTCAGC
CCTGCAGTCCCACCAGCCCGTGGCCAGGCCCGTCTCCGTGGGGCTTTCCAGGAGGCGCCTCCCTGCCGCGGTGCCAGAGCCAGACTTGGA
GGAGGAGCCAGTGCCTGACCTGCTGGGCAGCATCCTGTCGGGCCAGAGCCTCCTGATGCTGGGCAGCAGTGATGTCATCATCCACCGCGA
CGGCTCCCTCAGCGCCAAGAGGGCGGCTCCAGTTTCTTTTCAGCGAAACTCAGGCAGTCTGTCCAGAGGGGAAGAAGGATTCAAGGGCTG
CCTGCAGCCCCGAGCACTGCCCTCCGGGAGCCCGGCCCAAGGCCCGTCAGGAAACAGGCCACAGAGCACAGGGCTCAGCTGTCAAGGCAG
GTCCCGCACCCCCGCCCGCACCGCGGGGGCGCCTGTGAGGCTGGACTTGCCAGCAGCCCCTGGGGCGGTTCAGGCTCGGAACTTGTCAAA
TGGGAGTGTGCCTGGCTTCAGACAGAGCCACAGCCCCTGGTTCAACGGCACCAACAAGCACACCTTGCCCCTTGCCTCTGCCGCGTCTAA
GATCTCAAGCAGAGATTCTAAGCCCCCATGTCGCAGTGTGGTGCCGGGGCCTCCCCTGAAGCCAGCGCCCAGAAGAACAGACATCTCTGA
GCTACCCAGGATACCAAAGATCAGGAGAGATGACGGTGGTGGCAGACGGGATGCGGCCCCGGCCCACGGGCAGAGCATTGAGATCCCCAG
TGCCTGCATCAGCCGACTGACTGGCAGGGAGGGCACCGGGCAGCCAGGGCGAGGCACACGGGCAGAGAGCGAGGCCAGCAGCAGGGTGCC
CCGGGAGCCCGGGGTGCACACGGGCAGCTCCCGGCCCCCAGCCCCCAGCTCCCATGGCAGTTTGGCCCCACTGGGACCATCAAGAGGGAA
AGGGGTCGGGTCGACCTTTGAGAGCTTCCGGATCAATATTCCTGGAAACATGGCACATTCCAGCCAGCTCTCCAGCCCTGGCTTCTGTAA
CACGTTCCGGCCTGTGGACGATAAGGAGCAGAGGAAGGAGAACCCCTCACCCCTCTTCTCCATCAAGAAGACGAAGCAGCTGCGGAGCGA
GGTCTACGACCCATCCGACCCCACCGGCTCCGACTCCAGCGCCCCTGGCAGCAGCCCCGAGAGGTCTGGCCCCGGCCTCCTGCCCTCTGA
GATCACACGAACCATCTCCATCAACAGCCCGAAGGCCCAGACGGTGCAGGCTGTGCGCTGCGTCACCTCCTACACGGTGGAGAGCATCTT
TGGTACAGAGCCCGAACCCCCTCTCGGACCGTCCTCCGCCATGTCCAAGCTCCGGGGTGCAGTGGCTGCCGAGGGGGCCTCTGACACGGA
GCGAGAGGAGCCCACAGAGAGCCAGGGCCTGGCTGCCCGGCTGCGGAGGCCATCCCCCCCAGAGCCCTGGGATGAGGAGGATGGGGCGTC
TTGCAGCACCTTCTTTGGCTCTGAGGAGCGGACGGTGACCTGTGTGACTGTCGTGGAGCCGGAAGCCCCACCCAGCCCGGACGTGCTGCA
GGCTGCCACCCACAGAGTCGTGGAGCTCAGGCCCCCTTCCCGGTCCCGCTCCACATCCAGCTCCCGCAGCAGGAAGAAGGCCAAGAGGAA
GAGGGTGTCCAGGGAGCACGGACGGACGCGCTCTGGGACGCGCTCTGAATCCAGGGACAGGAGCTCGAGGTCAGCGTCACCATCAGTGGG
TGAGGAGCGCCCCAGGAGGCAGCGGTCCAAGGCCAAGAGCCGGCGGTCCTCCAGTGACCGCTCCAGCAGCCGAGAGCGAGCTAAGAGGAA
GAAAGCCAAGGACAAGAGCAGGGAGCACAGGCGGGGCCCCTGGGGCCACAGCCGGAGGACGTCCCGGTCGCGGTCGGGGAGCCCTGGCAG
CTCTTCCTATGAGCACTATGAGAGTAGGAAGAAGAAGAAAAGGAGATCAGCGTCCAGACCTCGGGGAAGGGAGTGCTCCCCCACCAGCAG
CCTGGAGAGGCTCTGCAGGCACAAGCATCAGCGGGAACGCAGCCACGAGCGGCCAGACAGGAAGGAGAGTGTGGCGTGGCCCCGAGACCG
GAGGAAGCGGAGGTCCCGGTCCCCAAGCTCGGAGCACAGGGCACGGGAGCACAGGCGGCCTCGGTCCCGTGAGAAGTGGCCGCAGACCCG
GTCCCATTCCCCAGAGAGGAAGGGGGCTGTGAGGGAGGCTTCCCCAGCGCCCCTTGCACAGGGGGAGCCAGGGCGGGAAGACCTCCCCAC
CAGGTTGCCAGCCTTGGGGGAAGCACATGTCTCGCCGGAGGTGGCTACGGCCGACAAGGCCCCCCTGCAGGCTCCCCCTGTCCTGGAGGT
GGCAGCTGAGTGTGAGCCGGACGACCTGGACCTGGATTATGGCGACTCCGTGGAGGCCGGACACGTCTTTGATGATTTCTCAAGCGACGC
CGTTTTCATCCAGCTCGATGACATGAGCTCGCCACCTTCTCCCGAAAGCACAGACTCTTCCCCGGAGCGAGACTTCCCACTGAAGCCTGC
GTTGCCCCCAGCCAGCCTGGCCGTGGCCGCCATCCAGAGGGAGGTGTCATTGATGCACGATGAAGACCCTTCGCAGCCCCCACCCCTGCC
AGAGGGCACCCAGGAGCCACATTTGCTCAGGCCGGACGCGGCTGAGAAGGCTGAGGCACCCAGTTCCCCGGATGTGGCGCCTGCGGGGAA
GGAAGACAGCCCCTCTGCGAGTGGGAGGGTACAGGAGGCAGCCCGGCCTGAGGAGGTGGTTTCGCAGACCCCCCTGCTGCGGTCCAGAGC
CCTGGTGAAGCGGGTCACCTGGAACCTGCAGGAGTCGGAGAGCAGCGCCCCCGCCGAGGACAGAGCCCCCCGGGCACCACTTCACAGGCC
ACAGAAGCCCCGAGAAGGAGCCTGGGACATGGAGGATGTGGCCCCCACAGGGGTCAGGCAGGTGTTCTCCGAGCTGCCCTTTCCCAGTCA
CGTGCTTCCGGAACCCGGGTTCCCAGACACAGACCCCTCTCAGGTTTACAGCCCCGGCCTGCCGCCTGCCCCGGCCCAGCCCTCAAGCAT
CCCACCCTGCGCACTGGTCAGCCAGCCCACGGTCCAGTTCATCCTTCAGGGGAGCCTGCCGCTAGTGGGCTGTGGGGCAGCACAGACCCT
GGCCCCAGTGCCCGCTGCCCTGACCCCAGCCTCAGAGCCAGCCAGTCAAGCCACTGCAGCCAGCAACTCGGAGGAGAAGACCCCGGCCCC
CAGGCTAGCTGCGGAGAAAACCAAGAAGGAGGAGTACATGAAGAAGCTGCACATGCAGGAGCGTGCTGTGGAGGAGGTGAAGCTGGCCAT
CAAGCCCTTCTACCAGAAGAGGGAGGTGACCAAGGAGGAGTACAAGGACATCCTGCGCAAGGCCGTGCAGAAGATCTGCCACAGCAAGAG
TGGAGAGATCAACCCCGTGAAGGTGGCCAACCTGGTGAAGGCGTACGTGGACAAGTACAGGCACATGCGCAGGCACAAGAAACCAGAGGC
CGGGGAGGAGCCGCCCACGCAGGGGGCCGAGGGCTGAGGCCAGGCAATCACGGGCTATGCCCGGGGAGCTGTCGGGAGTGGCGGGAATCG
GGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAATCGGGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAAATGGGGGGCATCACC

>84753_84753_2_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000413872_length(amino acids)=1367AA_BP=103
MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCL
TELILTNNSLVELSEATTRSRIARTLGLRRPVHSSCIPSVLKPVEPSLGLLRADIGAASLSLFGDPYELDPFDSEELSANPLSPLSAKRR
ALSRSALQSHQPVARPVSVGLSRRRLPAAVPEPDLEEEPVPDLLGSILSGQSLLMLGSSDVIIHRDGSLSAKRAAPVSFQRNSGSLSRGE
EGFKGCLQPRALPSGSPAQGPSGNRPQSTGLSCQGRSRTPARTAGAPVRLDLPAAPGAVQARNLSNGSVPGFRQSHSPWFNGTNKHTLPL
ASAASKISSRDSKPPCRSVVPGPPLKPAPRRTDISELPRIPKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGTGQPGRGTRAESE
ASSRVPREPGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCNTFRPVDDKEQRKENPSPLFSIKKT
KQLRSEVYDPSDPTGSDSSAPGSSPERSGPGLLPSEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAVAAE
GASDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPPSPDVLQAATHRVVELRPPSRSRSTSSSRSR
KKAKRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRSR
SGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQRERSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSRE
KWPQTRSHSPERKGAVREASPAPLAQGEPGREDLPTRLPALGEAHVSPEVATADKAPLQAPPVLEVAAECEPDDLDLDYGDSVEAGHVFD
DFSSDAVFIQLDDMSSPPSPESTDSSPERDFPLKPALPPASLAVAAIQREVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSPD
VAPAGKEDSPSASGRVQEAARPEEVVSQTPLLRSRALVKRVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFSE
LPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALVSQPTVQFILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNSE
EKTPAPRLAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQKICHSKSGEINPVKVANLVKAYVDKYRHMRR

--------------------------------------------------------------
>84753_84753_3_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000416188_length(transcript)=4364nt_BP=382nt
GGGGCACGCTGGGACGTCTCGCTGGCGGGAGGCCACGGGCTTTCCACAGCGCGGGGGAACGGGAGGCTGCAGGATGGTCAAGCTGACGGC
GGAGCTGATCGAGCAGGCGGCGCAGTACACCAACGCGGTGCGCGACCGGGAGCTGGACCTCCGGGGGTATAAAATTCCCGTCATTGAAAA
TCTAGGTGCTACGTTAGACCAGTTTGATGCTATTGATTTTTCTGACAATGAGATCAGGAAACTGGATGGTTTTCCTTTGTTGAGAAGACT
GAAAACATTGTTAGTGAACAACAACAGAATATGCCGTATAGGTGAGGGACTTGATCAGGCTCTGCCCTGTCTGACAGAACTCATTCTCAC
CAATAATAGTCTCGTGGAACTGAGTGAAGCCACCACTCGCTCTCGAATCGCGCGGACGCTGGGCCTGCGCAGGCCTGTTCACAGCAGCTG
CATCCCGTCAGTGTTGAAGCCAGTGGAGCCCTCTTTGGGGCTGCTGAGAGCGGATATTGGAGCTGCCTCTCTGTCTCTGTTTGGAGATCC
TTATGAGCTGGATCCCTTCGACAGTGAAGAGCTTTCTGCAAACCCTCTTTCCCCTCTGAGTGCCAAGAGACGGGCTCTGTCCCGGTCAGC
CCTGCAGTCCCACCAGCCCGTGGCCAGGCCCGTCTCCGTGGGGCTTTCCAGGAGGCGCCTCCCTGCCGCGGTGCCAGAGCCAGACTTGGA
GGAGGAGCCAGTGCCTGACCTGCTGGGCAGCATCCTGTCGGGCCAGAGCCTCCTGATGCTGGGCAGCAGTGATGTCATCATCCACCGCGA
CGGCTCCCTCAGCGCCAAGAGGGCGGCTCCAGTTTCTTTTCAGCGAAACTCAGGCAGTCTGTCCAGAGGGGAAGAAGGATTCAAGGGCTG
CCTGCAGCCCCGAGCACTGCCCTCCGGGAGCCCGGCCCAAGGCCCGTCAGGAAACAGGCCACAGAGCACAGGGCTCAGCTGTCAAGGCAG
GTCCCGCACCCCCGCCCGCACCGCGGGGGCGCCTGTGAGGCTGGACTTGCCAGCAGCCCCTGGGGCGGTTCAGGCTCGGAACTTGTCAAA
TGGGAGTGTGCCTGGCTTCAGACAGAGCCACAGCCCCTGGTTCAACGGCACCAACAAGCACACCTTGCCCCTTGCCTCTGCCGCGTCTAA
GATCTCAAGCAGAGATTCTAAGCCCCCATGTCGCAGTGTGGTGCCGGGGCCTCCCCTGAAGCCAGCGCCCAGAAGAACAGACATCTCTGA
GCTACCCAGGATACCAAAGATCAGGAGAGATGACGGTGGTGGCAGACGGGATGCGGCCCCGGCCCACGGGCAGAGCATTGAGATCCCCAG
TGCCTGCATCAGCCGACTGACTGGCAGGGAGGGCACCGGGCAGCCAGGGCGAGGCACACGGGCAGAGAGCGAGGCCAGCAGCAGGGTGCC
CCGGGAGCCCGGGGTGCACACGGGCAGCTCCCGGCCCCCAGCCCCCAGCTCCCATGGCAGTTTGGCCCCACTGGGACCATCAAGAGGGAA
AGGGGTCGGGTCGACCTTTGAGAGCTTCCGGATCAATATTCCTGGAAACATGGCACATTCCAGCCAGCTCTCCAGCCCTGGCTTCTGTAA
CACGTTCCGGCCTGTGGACGATAAGGAGCAGAGGAAGGAGAACCCCTCACCCCTCTTCTCCATCAAGAAGACGAAGCAGCTGCGGAGCGA
GGTCTACGACCCATCCGACCCCACCGGCTCCGACTCCAGCGCCCCTGGCAGCAGCCCCGAGAGGTCTGGCCCCGGCCTCCTGCCCTCTGA
GATCACACGAACCATCTCCATCAACAGCCCGAAGGCCCAGACGGTGCAGGCTGTGCGCTGCGTCACCTCCTACACGGTGGAGAGCATCTT
TGGTACAGAGCCCGAACCCCCTCTCGGACCGTCCTCCGCCATGTCCAAGCTCCGGGGTGCAGTGGCTGCCGAGGGGGCCTCTGACACGGA
GCGAGAGGAGCCCACAGAGAGCCAGGGCCTGGCTGCCCGGCTGCGGAGGCCATCCCCCCCAGAGCCCTGGGATGAGGAGGATGGGGCGTC
TTGCAGCACCTTCTTTGGCTCTGAGGAGCGGACGGTGACCTGTGTGACTGTCGTGGAGCCGGAAGCCCCACCCAGCCCGGACGTGCTGCA
GGCTGCCACCCACAGAGTCGTGGAGCTCAGGCCCCCTTCCCGGTCCCGCTCCACATCCAGCTCCCGCAGCAGGAAGAAGGCCAAGAGGAA
GAGGGTGTCCAGGGAGCACGGACGGACGCGCTCTGGGACGCGCTCTGAATCCAGGGACAGGAGCTCGAGGTCAGCGTCACCATCAGTGGG
TGAGGAGCGCCCCAGGAGGCAGCGGTCCAAGGCCAAGAGCCGGCGGTCCTCCAGTGACCGCTCCAGCAGCCGAGAGCGAGCTAAGAGGAA
GAAAGCCAAGGACAAGAGCAGGGAGCACAGGCGGGGCCCCTGGGGCCACAGCCGGAGGACGTCCCGGTCGCGGTCGGGGAGCCCTGGCAG
CTCTTCCTATGAGCACTATGAGAGTAGGAAGAAGAAGAAAAGGAGATCAGCGTCCAGACCTCGGGGAAGGGAGTGCTCCCCCACCAGCAG
CCTGGAGAGGCTCTGCAGGCACAAGCATCAGCGGGAACGCAGCCACGAGCGGCCAGACAGGAAGGAGAGTGTGGCGTGGCCCCGAGACCG
GAGGAAGCGGAGGTCCCGGTCCCCAAGCTCGGAGCACAGGGCACGGGAGCACAGGCGGCCTCGGTCCCGTGAGAAGTGGCCGCAGACCCG
GTCCCATTCCCCAGAGAGGAAGGGGGCTGTGAGGGAGGCTTCCCCAGCGCCCCTTGCACAGGGGGAGCCAGGGCGGGAAGACCTCCCCAC
CAGGTTGCCAGCCTTGGGGGAAGCACATGTCTCGCCGGAGGTGGCTACGGCCGACAAGGCCCCCCTGCAGGCTCCCCCTGTCCTGGAGGT
GGCAGCTGAGTGTGAGCCGGACGACCTGGACCTGGATTATGGCGACTCCGTGGAGGCCGGACACGTCTTTGATGATTTCTCAAGCGACGC
CGTTTTCATCCAGCTCGATGACATGAGCTCGCCACCTTCTCCCGAAAGCACAGACTCTTCCCCGGAGCGAGACTTCCCACTGAAGCCTGC
GTTGCCCCCAGCCAGCCTGGCCGTGGCCGCCATCCAGAGGGAGGTGTCATTGATGCACGATGAAGACCCTTCGCAGCCCCCACCCCTGCC
AGAGGGCACCCAGGAGCCACATTTGCTCAGGCCGGACGCGGCTGAGAAGGCTGAGGCACCCAGTTCCCCGGATGTGGCGCCTGCGGGGAA
GGAAGACAGCCCCTCTGCGAGTGGGAGGGTACAGGAGGCAGCCCGGCCTGAGGAGGTGGTTTCGCAGACCCCCCTGCTGCGGTCCAGAGC
CCTGGTGAAGCGGGTCACCTGGAACCTGCAGGAGTCGGAGAGCAGCGCCCCCGCCGAGGACAGAGCCCCCCGGGCACCACTTCACAGGCC
ACAGAAGCCCCGAGAAGGAGCCTGGGACATGGAGGATGTGGCCCCCACAGGGGTCAGGCAGGTGTTCTCCGAGCTGCCCTTTCCCAGTCA
CGTGCTTCCGGAACCCGGGTTCCCAGACACAGACCCCTCTCAGGTTTACAGCCCCGGCCTGCCGCCTGCCCCGGCCCAGCCCTCAAGCAT
CCCACCCTGCGCACTGGTCAGCCAGCCCACGGTCCAGTTCATCCTTCAGGGGAGCCTGCCGCTAGTGGGCTGTGGGGCAGCACAGACCCT
GGCCCCAGTGCCCGCTGCCCTGACCCCAGCCTCAGAGCCAGCCAGTCAAGCCACTGCAGCCAGCAACTCGGAGGAGAAGACCCCGGCCCC
CAGGCTAGCTGCGGAGAAAACCAAGAAGGAGGAGTACATGAAGAAGCTGCACATGCAGGAGCGTGCTGTGGAGGAGGTGAAGCTGGCCAT
CAAGCCCTTCTACCAGAAGAGGGAGGTGACCAAGGAGGAGTACAAGGACATCCTGCGCAAGGCCGTGCAGAAGATCTGCCACAGCAAGAG
TGGAGAGATCAACCCCGTGAAGGTGGCCAACCTGGTGAAGGCGTACGTGGACAAGTACAGGCACATGCGCAGGCACAAGAAACCAGAGGC
CGGGGAGGAGCCGCCCACGCAGGGGGCCGAGGGCTGAGGCCAGGCAATCACGGGCTATGCCCGGGGAGCTGTCGGGAGTGGCGGGAATCG
GGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAATCGGGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAAATGGGGGGCATCACC

>84753_84753_3_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000416188_length(amino acids)=1367AA_BP=103
MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCL
TELILTNNSLVELSEATTRSRIARTLGLRRPVHSSCIPSVLKPVEPSLGLLRADIGAASLSLFGDPYELDPFDSEELSANPLSPLSAKRR
ALSRSALQSHQPVARPVSVGLSRRRLPAAVPEPDLEEEPVPDLLGSILSGQSLLMLGSSDVIIHRDGSLSAKRAAPVSFQRNSGSLSRGE
EGFKGCLQPRALPSGSPAQGPSGNRPQSTGLSCQGRSRTPARTAGAPVRLDLPAAPGAVQARNLSNGSVPGFRQSHSPWFNGTNKHTLPL
ASAASKISSRDSKPPCRSVVPGPPLKPAPRRTDISELPRIPKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGTGQPGRGTRAESE
ASSRVPREPGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCNTFRPVDDKEQRKENPSPLFSIKKT
KQLRSEVYDPSDPTGSDSSAPGSSPERSGPGLLPSEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAVAAE
GASDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPPSPDVLQAATHRVVELRPPSRSRSTSSSRSR
KKAKRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRSR
SGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQRERSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSRE
KWPQTRSHSPERKGAVREASPAPLAQGEPGREDLPTRLPALGEAHVSPEVATADKAPLQAPPVLEVAAECEPDDLDLDYGDSVEAGHVFD
DFSSDAVFIQLDDMSSPPSPESTDSSPERDFPLKPALPPASLAVAAIQREVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSPD
VAPAGKEDSPSASGRVQEAARPEEVVSQTPLLRSRALVKRVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFSE
LPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALVSQPTVQFILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNSE
EKTPAPRLAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQKICHSKSGEINPVKVANLVKAYVDKYRHMRR

--------------------------------------------------------------
>84753_84753_4_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000533464_length(transcript)=4367nt_BP=382nt
GGGGCACGCTGGGACGTCTCGCTGGCGGGAGGCCACGGGCTTTCCACAGCGCGGGGGAACGGGAGGCTGCAGGATGGTCAAGCTGACGGC
GGAGCTGATCGAGCAGGCGGCGCAGTACACCAACGCGGTGCGCGACCGGGAGCTGGACCTCCGGGGGTATAAAATTCCCGTCATTGAAAA
TCTAGGTGCTACGTTAGACCAGTTTGATGCTATTGATTTTTCTGACAATGAGATCAGGAAACTGGATGGTTTTCCTTTGTTGAGAAGACT
GAAAACATTGTTAGTGAACAACAACAGAATATGCCGTATAGGTGAGGGACTTGATCAGGCTCTGCCCTGTCTGACAGAACTCATTCTCAC
CAATAATAGTCTCGTGGAACTGAGTGAAGCCACCACTCGCTCTCGAATCGCGCGGACGCTGGGCCTGCGCAGGCCTGTTCACAGCAGCTG
CATCCCGTCAGTGTTGAAGCCAGTGGAGCCCTCTTTGGGGCTGCTGAGAGCGGATATTGGAGCTGCCTCTCTGTCTCTGTTTGGAGATCC
TTATGAGCTGGATCCCTTCGACAGCAGTGAAGAGCTTTCTGCAAACCCTCTTTCCCCTCTGAGTGCCAAGAGACGGGCTCTGTCCCGGTC
AGCCCTGCAGTCCCACCAGCCCGTGGCCAGGCCCGTCTCCGTGGGGCTTTCCAGGAGGCGCCTCCCTGCCGCGGTGCCAGAGCCAGACTT
GGAGGAGGAGCCAGTGCCTGACCTGCTGGGCAGCATCCTGTCGGGCCAGAGCCTCCTGATGCTGGGCAGCAGTGATGTCATCATCCACCG
CGACGGCTCCCTCAGCGCCAAGAGGGCGGCTCCAGTTTCTTTTCAGCGAAACTCAGGCAGTCTGTCCAGAGGGGAAGAAGGATTCAAGGG
CTGCCTGCAGCCCCGAGCACTGCCCTCCGGGAGCCCGGCCCAAGGCCCGTCAGGAAACAGGCCACAGAGCACAGGGCTCAGCTGTCAAGG
CAGGTCCCGCACCCCCGCCCGCACCGCGGGGGCGCCTGTGAGGCTGGACTTGCCAGCAGCCCCTGGGGCGGTTCAGGCTCGGAACTTGTC
AAATGGGAGTGTGCCTGGCTTCAGACAGAGCCACAGCCCCTGGTTCAACGGCACCAACAAGCACACCTTGCCCCTTGCCTCTGCCGCGTC
TAAGATCTCAAGCAGAGATTCTAAGCCCCCATGTCGCAGTGTGGTGCCGGGGCCTCCCCTGAAGCCAGCGCCCAGAAGAACAGACATCTC
TGAGCTACCCAGGATACCAAAGATCAGGAGAGATGACGGTGGTGGCAGACGGGATGCGGCCCCGGCCCACGGGCAGAGCATTGAGATCCC
CAGTGCCTGCATCAGCCGACTGACTGGCAGGGAGGGCACCGGGCAGCCAGGGCGAGGCACACGGGCAGAGAGCGAGGCCAGCAGCAGGGT
GCCCCGGGAGCCCGGGGTGCACACGGGCAGCTCCCGGCCCCCAGCCCCCAGCTCCCATGGCAGTTTGGCCCCACTGGGACCATCAAGAGG
GAAAGGGGTCGGGTCGACCTTTGAGAGCTTCCGGATCAATATTCCTGGAAACATGGCACATTCCAGCCAGCTCTCCAGCCCTGGCTTCTG
TAACACGTTCCGGCCTGTGGACGATAAGGAGCAGAGGAAGGAGAACCCCTCACCCCTCTTCTCCATCAAGAAGACGAAGCAGCTGCGGAG
CGAGGTCTACGACCCATCCGACCCCACCGGCTCCGACTCCAGCGCCCCTGGCAGCAGCCCCGAGAGGTCTGGCCCCGGCCTCCTGCCCTC
TGAGATCACACGAACCATCTCCATCAACAGCCCGAAGGCCCAGACGGTGCAGGCTGTGCGCTGCGTCACCTCCTACACGGTGGAGAGCAT
CTTTGGTACAGAGCCCGAACCCCCTCTCGGACCGTCCTCCGCCATGTCCAAGCTCCGGGGTGCAGTGGCTGCCGAGGGGGCCTCTGACAC
GGAGCGAGAGGAGCCCACAGAGAGCCAGGGCCTGGCTGCCCGGCTGCGGAGGCCATCCCCCCCAGAGCCCTGGGATGAGGAGGATGGGGC
GTCTTGCAGCACCTTCTTTGGCTCTGAGGAGCGGACGGTGACCTGTGTGACTGTCGTGGAGCCGGAAGCCCCACCCAGCCCGGACGTGCT
GCAGGCTGCCACCCACAGAGTCGTGGAGCTCAGGCCCCCTTCCCGGTCCCGCTCCACATCCAGCTCCCGCAGCAGGAAGAAGGCCAAGAG
GAAGAGGGTGTCCAGGGAGCACGGACGGACGCGCTCTGGGACGCGCTCTGAATCCAGGGACAGGAGCTCGAGGTCAGCGTCACCATCAGT
GGGTGAGGAGCGCCCCAGGAGGCAGCGGTCCAAGGCCAAGAGCCGGCGGTCCTCCAGTGACCGCTCCAGCAGCCGAGAGCGAGCTAAGAG
GAAGAAAGCCAAGGACAAGAGCAGGGAGCACAGGCGGGGCCCCTGGGGCCACAGCCGGAGGACGTCCCGGTCGCGGTCGGGGAGCCCTGG
CAGCTCTTCCTATGAGCACTATGAGAGTAGGAAGAAGAAGAAAAGGAGATCAGCGTCCAGACCTCGGGGAAGGGAGTGCTCCCCCACCAG
CAGCCTGGAGAGGCTCTGCAGGCACAAGCATCAGCGGGAACGCAGCCACGAGCGGCCAGACAGGAAGGAGAGTGTGGCGTGGCCCCGAGA
CCGGAGGAAGCGGAGGTCCCGGTCCCCAAGCTCGGAGCACAGGGCACGGGAGCACAGGCGGCCTCGGTCCCGTGAGAAGTGGCCGCAGAC
CCGGTCCCATTCCCCAGAGAGGAAGGGGGCTGTGAGGGAGGCTTCCCCAGCGCCCCTTGCACAGGGGGAGCCAGGGCGGGAAGACCTCCC
CACCAGGTTGCCAGCCTTGGGGGAAGCACATGTCTCGCCGGAGGTGGCTACGGCCGACAAGGCCCCCCTGCAGGCTCCCCCTGTCCTGGA
GGTGGCAGCTGAGTGTGAGCCGGACGACCTGGACCTGGATTATGGCGACTCCGTGGAGGCCGGACACGTCTTTGATGATTTCTCAAGCGA
CGCCGTTTTCATCCAGCTCGATGACATGAGCTCGCCACCTTCTCCCGAAAGCACAGACTCTTCCCCGGAGCGAGACTTCCCACTGAAGCC
TGCGTTGCCCCCAGCCAGCCTGGCCGTGGCCGCCATCCAGAGGGAGGTGTCATTGATGCACGATGAAGACCCTTCGCAGCCCCCACCCCT
GCCAGAGGGCACCCAGGAGCCACATTTGCTCAGGCCGGACGCGGCTGAGAAGGCTGAGGCACCCAGTTCCCCGGATGTGGCGCCTGCGGG
GAAGGAAGACAGCCCCTCTGCGAGTGGGAGGGTACAGGAGGCAGCCCGGCCTGAGGAGGTGGTTTCGCAGACCCCCCTGCTGCGGTCCAG
AGCCCTGGTGAAGCGGGTCACCTGGAACCTGCAGGAGTCGGAGAGCAGCGCCCCCGCCGAGGACAGAGCCCCCCGGGCACCACTTCACAG
GCCACAGAAGCCCCGAGAAGGAGCCTGGGACATGGAGGATGTGGCCCCCACAGGGGTCAGGCAGGTGTTCTCCGAGCTGCCCTTTCCCAG
TCACGTGCTTCCGGAACCCGGGTTCCCAGACACAGACCCCTCTCAGGTTTACAGCCCCGGCCTGCCGCCTGCCCCGGCCCAGCCCTCAAG
CATCCCACCCTGCGCACTGGTCAGCCAGCCCACGGTCCAGTTCATCCTTCAGGGGAGCCTGCCGCTAGTGGGCTGTGGGGCAGCACAGAC
CCTGGCCCCAGTGCCCGCTGCCCTGACCCCAGCCTCAGAGCCAGCCAGTCAAGCCACTGCAGCCAGCAACTCGGAGGAGAAGACCCCGGC
CCCCAGGCTAGCTGCGGAGAAAACCAAGAAGGAGGAGTACATGAAGAAGCTGCACATGCAGGAGCGTGCTGTGGAGGAGGTGAAGCTGGC
CATCAAGCCCTTCTACCAGAAGAGGGAGGTGACCAAGGAGGAGTACAAGGACATCCTGCGCAAGGCCGTGCAGAAGATCTGCCACAGCAA
GAGTGGAGAGATCAACCCCGTGAAGGTGGCCAACCTGGTGAAGGCGTACGTGGACAAGTACAGGCACATGCGCAGGCACAAGAAACCAGA
GGCCGGGGAGGAGCCGCCCACGCAGGGGGCCGAGGGCTGAGGCCAGGCAATCACGGGCTATGCCCGGGGAGCTGTCGGGAGTGGCGGGAA
TCGGGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAATCGGGGCCATGCCCGGGGAGCTGTCGGGAGTGGCGGGAAATGGGGGGCATC

>84753_84753_4_SNRPA1-PHRF1_SNRPA1_chr15_101832167_ENST00000254193_PHRF1_chr11_605119_ENST00000533464_length(amino acids)=1368AA_BP=103
MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCL
TELILTNNSLVELSEATTRSRIARTLGLRRPVHSSCIPSVLKPVEPSLGLLRADIGAASLSLFGDPYELDPFDSSEELSANPLSPLSAKR
RALSRSALQSHQPVARPVSVGLSRRRLPAAVPEPDLEEEPVPDLLGSILSGQSLLMLGSSDVIIHRDGSLSAKRAAPVSFQRNSGSLSRG
EEGFKGCLQPRALPSGSPAQGPSGNRPQSTGLSCQGRSRTPARTAGAPVRLDLPAAPGAVQARNLSNGSVPGFRQSHSPWFNGTNKHTLP
LASAASKISSRDSKPPCRSVVPGPPLKPAPRRTDISELPRIPKIRRDDGGGRRDAAPAHGQSIEIPSACISRLTGREGTGQPGRGTRAES
EASSRVPREPGVHTGSSRPPAPSSHGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCNTFRPVDDKEQRKENPSPLFSIKK
TKQLRSEVYDPSDPTGSDSSAPGSSPERSGPGLLPSEITRTISINSPKAQTVQAVRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAVAA
EGASDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPPSPDVLQAATHRVVELRPPSRSRSTSSSRS
RKKAKRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRS
RSGSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRHKHQRERSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSR
EKWPQTRSHSPERKGAVREASPAPLAQGEPGREDLPTRLPALGEAHVSPEVATADKAPLQAPPVLEVAAECEPDDLDLDYGDSVEAGHVF
DDFSSDAVFIQLDDMSSPPSPESTDSSPERDFPLKPALPPASLAVAAIQREVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSP
DVAPAGKEDSPSASGRVQEAARPEEVVSQTPLLRSRALVKRVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFS
ELPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALVSQPTVQFILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNS
EEKTPAPRLAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVTKEEYKDILRKAVQKICHSKSGEINPVKVANLVKAYVDKYRHMR

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Fusion Gene PPI Analysis for SNRPA1-PHRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SNRPA1-PHRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SNRPA1-PHRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource