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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AURKA-ACACA (FusionGDB2 ID:8481)

Fusion Gene Summary for AURKA-ACACA

check button Fusion gene summary
Fusion gene informationFusion gene name: AURKA-ACACA
Fusion gene ID: 8481
HgeneTgene
Gene symbol

AURKA

ACACA

Gene ID

6790

31

Gene nameaurora kinase Aacetyl-CoA carboxylase alpha
SynonymsAIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7ACAC|ACACAD|ACC|ACC1|ACCA
Cytomap

20q13.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionaurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase aacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha
Modification date2020032920200313
UniProtAcc

O14965

Q13085

Ensembl transtripts involved in fusion geneENST00000312783, ENST00000347343, 
ENST00000371356, ENST00000395907, 
ENST00000395909, ENST00000395911, 
ENST00000395913, ENST00000395914, 
ENST00000395915, 		ENST00000335166, 
ENST00000353139, ENST00000360679, 
ENST00000361253, ENST00000394406, 
ENST00000416895, ENST00000588142, 
ENST00000589665, 
Fusion gene scores* DoF score6 X 8 X 3=14420 X 22 X 7=3080
# samples 821
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3080*10)=-3.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AURKA [Title/Abstract] AND ACACA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAURKA(54959325)-ACACA(35697127), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAURKA

GO:0006468

protein phosphorylation

21600873|21820309

HgeneAURKA

GO:0009611

response to wounding

19435814

HgeneAURKA

GO:0032091

negative regulation of protein binding

21820309

HgeneAURKA

GO:0097421

liver regeneration

19435814


check buttonFusion gene breakpoints across AURKA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ACACA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP224535AURKAchr20

54959325

-ACACAchr17

35697127

+


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Fusion Gene ORF analysis for AURKA-ACACA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000312783ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000312783ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000312783ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000312783ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000312783ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000312783ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000312783ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000312783ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000347343ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000371356ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395907ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395909ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395911ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395913ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395914ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000335166AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000353139AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000360679AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000361253AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000394406AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000416895AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000588142AURKAchr20

54959325

-ACACAchr17

35697127

+
5CDS-intronENST00000395915ENST00000589665AURKAchr20

54959325

-ACACAchr17

35697127

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AURKA-ACACA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AURKA-ACACA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:54959325/:35697127)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AURKA

O14965

ACACA

Q13085

FUNCTION: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Necessary for proper cilia disassembly prior to mitosis (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AURKA-ACACA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AURKA-ACACA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AURKA-ACACA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AURKA-ACACA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource