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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SNX18-WDR93 (FusionGDB2 ID:84901)

Fusion Gene Summary for SNX18-WDR93

Fusion gene summary

Fusion gene information	Fusion gene name: SNX18-WDR93
	Fusion gene ID: 84901
		Hgene	Tgene
	Gene symbol	SNX18	WDR93
	Gene ID	112574	56964
	Gene name	sorting nexin 18	WD repeat domain 93
	Synonyms	SH3PX2\|SH3PXD3B\|SNAG1	C1d-87\|CFAP297\|FAP297
	Cytomap	5q11.2	15q26.1
	Type of gene	protein-coding	protein-coding
	Description	sorting nexin-18SH3 and PX domain-containing protein 3Bsorting nexin associated golgi protein 1sorting nexin-associated Golgi protein 1	WD repeat-containing protein 93
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000326277, ENST00000343017, ENST00000381410,	ENST00000444934, ENST00000558000, ENST00000268130, ENST00000560294,
Fusion gene scores	* DoF score	4 X 6 X 4=96	7 X 8 X 4=224
	# samples	5	9
	** MAII score	log2(5/96*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SNX18 [Title/Abstract] AND WDR93 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SNX18(53815403)-WDR93(90270388), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SNX18	GO:0006897	endocytosis	20427313
Hgene	SNX18	GO:0043547	positive regulation of GTPase activity	20427313

Fusion gene breakpoints across SNX18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WDR93 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A18V-01A	SNX18	chr5	53815403	-	WDR93	chr15	90270388	+
ChimerDB4	BRCA	TCGA-BH-A18V-01A	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+

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Fusion Gene ORF analysis for SNX18-WDR93

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000326277	ENST00000444934	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
5CDS-intron	ENST00000326277	ENST00000558000	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
5CDS-intron	ENST00000343017	ENST00000444934	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
5CDS-intron	ENST00000343017	ENST00000558000	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
5CDS-intron	ENST00000381410	ENST00000444934	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
5CDS-intron	ENST00000381410	ENST00000558000	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
Frame-shift	ENST00000326277	ENST00000268130	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
Frame-shift	ENST00000326277	ENST00000560294	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
In-frame	ENST00000343017	ENST00000268130	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
In-frame	ENST00000343017	ENST00000560294	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
In-frame	ENST00000381410	ENST00000268130	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+
In-frame	ENST00000381410	ENST00000560294	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000343017

SNX18

chr5

53815403

ENST00000268130

WDR93

chr15

90270388

1581

153

1333

431

ENST00000343017

SNX18

chr5

53815403

ENST00000560294

WDR93

chr15

90270388

1497

153

1249

403

ENST00000381410

SNX18

chr5

53815403

ENST00000268130

WDR93

chr15

90270388

3239

1811

2991

995

ENST00000381410

SNX18

chr5

53815403

ENST00000560294

WDR93

chr15

90270388

3155

1811

2907

967

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000343017	ENST00000268130	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+	0.019163793	0.9808363
ENST00000343017	ENST00000560294	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+	0.024163486	0.9758365
ENST00000381410	ENST00000268130	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+	0.002478642	0.99752134
ENST00000381410	ENST00000560294	SNX18	chr5	53815403	+	WDR93	chr15	90270388	+	0.003404186	0.9965958

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Fusion Genomic Features for SNX18-WDR93

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SNX18	chr5	53815403	+	WDR93	chr15	90270387	+	9.19E-07	0.99999905
SNX18	chr5	53815403	+	WDR93	chr15	90270387	+	9.19E-07	0.99999905

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SNX18-WDR93

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:53815403/chr15:90270388)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000381410

1_61

540

625.0

Domain

SH3

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000381410

276_386

540

625.0

Domain

Tgene

WDR93

chr5:53815403

chr15:90270388

ENST00000268130

410_449

293

687.0

Repeat

Note=WD

Tgene

WDR93

chr5:53815403

chr15:90270388

ENST00000560294

410_449

293

659.0

Repeat

Note=WD

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000326277

1_61

629.0

Domain

SH3

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000326277

276_386

629.0

Domain

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000326277

421_628

629.0

Domain

Note=BAR

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000343017

1_61

592.0

Domain

SH3

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000343017

276_386

592.0

Domain

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000343017

421_628

592.0

Domain

Note=BAR

Hgene

SNX18

chr5:53815403

chr15:90270388

ENST00000381410

421_628

540

625.0

Domain

Note=BAR

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Fusion Gene Sequence for SNX18-WDR93

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>84901_84901_1_SNX18-WDR93_SNX18_chr5_53815403_ENST00000343017_WDR93_chr15_90270388_ENST00000268130_length(transcript)=1581nt_BP=153nt
GTAAAGCCTGGCCCTTAGAGCAGGTGATATGGAGTGTATTGTGCAGGCTGAAAGGGGCGACTTTGACAGCAGTACCACTGTGGGTTTCAG
AATCATATTCTACAGGTGAGGAAGCGAGCAGAGACGTGGACGCCTGGGTCTTTTCCCTAGAGTGCACCACATTCAAAAGCCCCCTGGAAG
TCTTTGCAAAGATCAAGGACTGCTACGGACTGGGCTCCGGGCAGAATCATTTCATCAAGGACAGTCAGTGGGAGCAGCAAGCTGAGATCT
TCAACGCTTCCTACAAGAAGTACCTAGATAGGGAGTGGGAGGAAGAGCCACTCAGTACGGCCACCTTCTATTTCCTTCTTCCTAGCTGCC
TATTTGCAATGCCACCGGAAGTCAAGGGCCCCTCAGGAATGGCCTGTGTCCTTGGTATACACTGGACCAGAAGTCACAATTTCTTCCTGT
ATTCACTAAACCGAACTCTAAAGGATAAAGCTGACCCCGAGGGTGTGTGGCCCTGTGCTGCGCCCATTGCAGTCTCTCAGCTCAGCTGCT
CCTCCTCCTACCTGGTGCTGGCCTGCGAGGATGGTGTGCTCACGCTGTGGGACCTGGCCAAAGGATTCCCTCTTGGGGTCGCTGCTCTTC
CTCAGGGATGTTTCTGCCAAAGCATTCACTTCCTAAAATATTTCTCGGTCCACAAAGGACAGAATATGTATCCTGAAGGTCAAGTGAAAT
CCCAAATGAAATGTGTGGTGCTGTGCACAGACGCCTCCCTCCATCTGGTGGAGGCTAGCGGGACCCAAGGACCCACCATCAGTGTGCTTG
TTGAGAGGCCTGTAAAGCACCTGGATAAAACCATCTGTGCCGTGGCCCCAGTCCCAGCCTTACCTGGCATGGTGCTCATCTTTTCCAAGA
ATGGCTCTGTGTGCCTTATGGATGTGGCCAAGCGTGAAATCATCTGTGCCTTTGCCCCTCCGGGAGCCTTTCCTCTGGAGGTCCCCTGGA
AGCCAGTGTTTGCTGTGTCTCCAGACCATCCATGTTTCCTGCTCCGAGGAGACTATTCACATGAAACTGCGTCCACCGACGATGCTGGAA
TCCAATATTCTGTTTTCTATTTTAATTTTGAGGCCTGCCCACTCCTGGAAAATATCTCAAAAAATTGTACCATTCCTCAAAGGGACTTGG
ATAACATGGCCTTCCCCCAAGCACTGCCACTGGAGAAGAGATGTGAGCGTTTCCTCCAGAAGAGCTATCGGAAGCTGGAGAAGAACCCAG
AGAAGGAGGAGGAGCACTGGGCCCGGCTTCAGAGGTACTCCTTGTCGCTCCAGAGAGAGAACTTCAAGAAGTGAGGCTGCCACCGCCCTG
GGATCTCTGAAAAGGAGGTTTCAGCCACGAGGCAGCTGCTCCCAGGACACTGAGGCCAAGAGAAATGTAACAGAGCCACAGCTCCACAGG
CCTGCACTCGGAGTCTGGGGCCTCTGCAGAGCCAGCAAGGGGAAAAGTATAATCTGGGGGACCTTCAACCACTAAGCCTCTTGTCAGAGC

>84901_84901_1_SNX18-WDR93_SNX18_chr5_53815403_ENST00000343017_WDR93_chr15_90270388_ENST00000268130_length(amino acids)=431AA_BP=39
MCRLKGATLTAVPLWVSESYSTGEEASRDVDAWVFSLECTTFKSPLEVFAKIKDCYGLGSGQNHFIKDSQWEQQAEIFNASYKKYLDREW
EEEPLSTATFYFLLPSCLFAMPPEVKGPSGMACVLGIHWTRSHNFFLYSLNRTLKDKADPEGVWPCAAPIAVSQLSCSSSYLVLACEDGV
LTLWDLAKGFPLGVAALPQGCFCQSIHFLKYFSVHKGQNMYPEGQVKSQMKCVVLCTDASLHLVEASGTQGPTISVLVERPVKHLDKTIC
AVAPVPALPGMVLIFSKNGSVCLMDVAKREIICAFAPPGAFPLEVPWKPVFAVSPDHPCFLLRGDYSHETASTDDAGIQYSVFYFNFEAC

--------------------------------------------------------------
>84901_84901_2_SNX18-WDR93_SNX18_chr5_53815403_ENST00000343017_WDR93_chr15_90270388_ENST00000560294_length(transcript)=1497nt_BP=153nt
GTAAAGCCTGGCCCTTAGAGCAGGTGATATGGAGTGTATTGTGCAGGCTGAAAGGGGCGACTTTGACAGCAGTACCACTGTGGGTTTCAG
AATCATATTCTACAGGTGAGGAAGCGAGCAGAGACGTGGACGCCTGGGTCTTTTCCCTAGAGTGCACCACATTCAAAAGCCCCCTGGAAG
TCTTTGCAAAGATCAAGGACTGCTACGGACTGGGCTCCGGGCAGAATCATTTCATCAAGGACAGTCAGTGGGAGCAGCAAGCTGAGATCT
TCAACGCTTCCTACAAGAAGTACCTAGATAGGGAGTGGGAGGAAGAGCCACTCAGTACGGCCACCTTCTATTTCCTTCTTCCTAGCTGCC
TATTTGCAATGCCACCGGAAGTCAAGGGCCCCTCAGGAATGGCCTGTGTCCTTGGTATACACTGGACCAGAAGTCACAATTTCTTCCTGT
ATTCACTAAACCGAACTCTAAAGGATAAAGCTGACCCCGAGGGTGTGTGGCCCTGTGCTGCGCCCATTGCAGTCTCTCAGCTCAGCTGCT
CCTCCTCCTACCTGGTGCTGGCCTGCGAGGATGGTGTGCTCACGCTGTGGGACCTGGCCAAAGGACAGAATATGTATCCTGAAGGTCAAG
TGAAATCCCAAATGAAATGTGTGGTGCTGTGCACAGACGCCTCCCTCCATCTGGTGGAGGCTAGCGGGACCCAAGGACCCACCATCAGTG
TGCTTGTTGAGAGGCCTGTAAAGCACCTGGATAAAACCATCTGTGCCGTGGCCCCAGTCCCAGCCTTACCTGGCATGGTGCTCATCTTTT
CCAAGAATGGCTCTGTGTGCCTTATGGATGTGGCCAAGCGTGAAATCATCTGTGCCTTTGCCCCTCCGGGAGCCTTTCCTCTGGAGGTCC
CCTGGAAGCCAGTGTTTGCTGTGTCTCCAGACCATCCATGTTTCCTGCTCCGAGGAGACTATTCACATGAAACTGCGTCCACCGACGATG
CTGGAATCCAATATTCTGTTTTCTATTTTAATTTTGAGGCCTGCCCACTCCTGGAAAATATCTCAAAAAATTGTACCATTCCTCAAAGGG
ACTTGGATAACATGGCCTTCCCCCAAGCACTGCCACTGGAGAAGAGATGTGAGCGTTTCCTCCAGAAGAGCTATCGGAAGCTGGAGAAGA
ACCCAGAGAAGGAGGAGGAGCACTGGGCCCGGCTTCAGAGGTACTCCTTGTCGCTCCAGAGAGAGAACTTCAAGAAGTGAGGCTGCCACC
GCCCTGGGATCTCTGAAAAGGAGGTTTCAGCCACGAGGCAGCTGCTCCCAGGACACTGAGGCCAAGAGAAATGTAACAGAGCCACAGCTC
CACAGGCCTGCACTCGGAGTCTGGGGCCTCTGCAGAGCCAGCAAGGGGAAAAGTATAATCTGGGGGACCTTCAACCACTAAGCCTCTTGT

>84901_84901_2_SNX18-WDR93_SNX18_chr5_53815403_ENST00000343017_WDR93_chr15_90270388_ENST00000560294_length(amino acids)=403AA_BP=39
MCRLKGATLTAVPLWVSESYSTGEEASRDVDAWVFSLECTTFKSPLEVFAKIKDCYGLGSGQNHFIKDSQWEQQAEIFNASYKKYLDREW
EEEPLSTATFYFLLPSCLFAMPPEVKGPSGMACVLGIHWTRSHNFFLYSLNRTLKDKADPEGVWPCAAPIAVSQLSCSSSYLVLACEDGV
LTLWDLAKGQNMYPEGQVKSQMKCVVLCTDASLHLVEASGTQGPTISVLVERPVKHLDKTICAVAPVPALPGMVLIFSKNGSVCLMDVAK
REIICAFAPPGAFPLEVPWKPVFAVSPDHPCFLLRGDYSHETASTDDAGIQYSVFYFNFEACPLLENISKNCTIPQRDLDNMAFPQALPL

--------------------------------------------------------------
>84901_84901_3_SNX18-WDR93_SNX18_chr5_53815403_ENST00000381410_WDR93_chr15_90270388_ENST00000268130_length(transcript)=3239nt_BP=1811nt
GGCGCTGCGAAGTGGAGGCGCTGCGAGCGGAGCCGCGCGGAGGGCGCGACCGGCTGGTCCGGGCAGCGTGGGTTTGCCGCCTTCGGGGCT
CCAGTCCGCGCGCCAGGGCTCGAGCAGTACCGCGGGCCCCTCAGGTGGGCCTCGGCTCGGGACGCCGGGAGTCGGGACCGCCAGTCGGGG
CGCCGGGACCATGGCGCTGCGCGCCCGGGCGCTGTACGACTTCAGGTCGGAGAACCCAGGAGAGATCTCGCTGCGAGAGCACGAGGTGCT
GAGCCTGTGCAGCGAGCAGGACATCGAGGGCTGGCTCGAGGGGGTCAACAGCCGCGGCGACCGCGGCCTCTTCCCGGCCTCCTATGTGCA
GGTGATCCGCGCCCCCGAGCCTGGCCCGGCGGGAGACGGCGGCCCGGGCGCCCCGGCCCGCTACGCCAATGTGCCCCCCGGGGGCTTCGA
GCCCCTGCCTGTCGCGCCCCCCGCCTCCTTCAAGCCGCCGCCTGACGCCTTCCAGGCGCTGCTGCAGCCACAGCAGGCGCCGCCTCCGAG
CACCTTCCAGCCGCCCGGCGCGGGCTTCCCGTACGGCGGGGGCGCCCTGCAGCCGTCGCCTCAGCAGCTCTACGGCGGCTACCAGGCCAG
CCAAGGCAGCGATGATGACTGGGACGACGAGTGGGACGACAGCTCCACGGTGGCGGACGAGCCGGGCGCTCTGGGCAGCGGAGCATACCC
GGACCTCGACGGCTCGTCTTCGGCGGGTGTGGGCGCAGCCGGCCGCTACCGCCTGTCCACGCGCTCCGACCTGTCCCTGGGTTCCCGCGG
CGGCTCGGTCCCCCCGCAGCACCACCCGTCGGGGCCCAAGAGCTCGGCCACCGTGAGCCGCAACCTCAATCGCTTCTCCACCTTCGTCAA
GTCCGGCGGGGAGGCCTTCGTGCTGGGGGAGGCGTCAGGCTTCGTGAAGGACGGGGACAAGCTGTGCGTGGTGCTGGGGCCCTATGGCCC
CGAGTGGCAGGAGAACCCCTACCCGTTCCAGTGCACCATCGACGACCCCACCAAGCAGACCAAGTTCAAGGGCATGAAGAGCTACATCTC
CTACAAGCTGGTGCCCACGCACACGCAGGTGCCGGTGCATCGGCGCTACAAGCACTTCGACTGGCTGTACGCGCGCCTGGCGGAGAAGTT
CCCGGTCATCTCCGTGCCCCACCTGCCCGAGAAGCAGGCCACCGGCCGCTTCGAGGAGGACTTCATCTCTAAGCGCAGGAAGGGCCTGAT
CTGGTGGATGAACCACATGGCCAGCCACCCAGTGCTGGCGCAGTGCGACGTCTTCCAGCACTTCCTGACGTGCCCCAGCAGCACCGACGA
GAAAGCCTGGAAGCAGGGCAAGAGGAAGGCCGAGAAGGACGAGATGGTGGGCGCCAACTTCTTCCTGACCCTTAGCACGCCCCCCGCCGC
TGCCCTTGACCTGCAGGAGGTGGAGAGCAAGATCGACGGCTTCAAGTGCTTCACCAAGAAGATGGACGACAGCGCGCTGCAGCTCAACCA
CACGGCCAACGAGTTCGCGCGCAAGCAGGTGACCGGCTTCAAAAAGGAGTATCAGAAGGTGGGCCAGTCCTTCCGCGGCCTCAGCCAGGC
CTTTGAGCTGGACCAGCAGGCCTTCTCGGTGGGCCTGAACCAGGCTATCGCCTTCACCGGAGATGCCTATGACGCCATTGGCGAGCTCTT
CGCGGAGCAGCCCAGGCAGGACCTGGATCCCGTCATGGACCTATTAGCGCTGTATCAGGGGCATCTGGCTAACTTCCCGGACATCATCCA
CGTTCAGAAAGGCACCACATTCAAAAGCCCCCTGGAAGTCTTTGCAAAGATCAAGGACTGCTACGGACTGGGCTCCGGGCAGAATCATTT
CATCAAGGACAGTCAGTGGGAGCAGCAAGCTGAGATCTTCAACGCTTCCTACAAGAAGTACCTAGATAGGGAGTGGGAGGAAGAGCCACT
CAGTACGGCCACCTTCTATTTCCTTCTTCCTAGCTGCCTATTTGCAATGCCACCGGAAGTCAAGGGCCCCTCAGGAATGGCCTGTGTCCT
TGGTATACACTGGACCAGAAGTCACAATTTCTTCCTGTATTCACTAAACCGAACTCTAAAGGATAAAGCTGACCCCGAGGGTGTGTGGCC
CTGTGCTGCGCCCATTGCAGTCTCTCAGCTCAGCTGCTCCTCCTCCTACCTGGTGCTGGCCTGCGAGGATGGTGTGCTCACGCTGTGGGA
CCTGGCCAAAGGATTCCCTCTTGGGGTCGCTGCTCTTCCTCAGGGATGTTTCTGCCAAAGCATTCACTTCCTAAAATATTTCTCGGTCCA
CAAAGGACAGAATATGTATCCTGAAGGTCAAGTGAAATCCCAAATGAAATGTGTGGTGCTGTGCACAGACGCCTCCCTCCATCTGGTGGA
GGCTAGCGGGACCCAAGGACCCACCATCAGTGTGCTTGTTGAGAGGCCTGTAAAGCACCTGGATAAAACCATCTGTGCCGTGGCCCCAGT
CCCAGCCTTACCTGGCATGGTGCTCATCTTTTCCAAGAATGGCTCTGTGTGCCTTATGGATGTGGCCAAGCGTGAAATCATCTGTGCCTT
TGCCCCTCCGGGAGCCTTTCCTCTGGAGGTCCCCTGGAAGCCAGTGTTTGCTGTGTCTCCAGACCATCCATGTTTCCTGCTCCGAGGAGA
CTATTCACATGAAACTGCGTCCACCGACGATGCTGGAATCCAATATTCTGTTTTCTATTTTAATTTTGAGGCCTGCCCACTCCTGGAAAA
TATCTCAAAAAATTGTACCATTCCTCAAAGGGACTTGGATAACATGGCCTTCCCCCAAGCACTGCCACTGGAGAAGAGATGTGAGCGTTT
CCTCCAGAAGAGCTATCGGAAGCTGGAGAAGAACCCAGAGAAGGAGGAGGAGCACTGGGCCCGGCTTCAGAGGTACTCCTTGTCGCTCCA
GAGAGAGAACTTCAAGAAGTGAGGCTGCCACCGCCCTGGGATCTCTGAAAAGGAGGTTTCAGCCACGAGGCAGCTGCTCCCAGGACACTG
AGGCCAAGAGAAATGTAACAGAGCCACAGCTCCACAGGCCTGCACTCGGAGTCTGGGGCCTCTGCAGAGCCAGCAAGGGGAAAAGTATAA

>84901_84901_3_SNX18-WDR93_SNX18_chr5_53815403_ENST00000381410_WDR93_chr15_90270388_ENST00000268130_length(amino acids)=995AA_BP=602
MRSGGAASGAARRARPAGPGSVGLPPSGLQSARQGSSSTAGPSGGPRLGTPGVGTASRGAGTMALRARALYDFRSENPGEISLREHEVLS
LCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPST
FQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGG
SVPPQHHPSGPKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISY
KLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEK
AWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAF
ELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGTTFKSPLEVFAKIKDCYGLGSGQNHFI
KDSQWEQQAEIFNASYKKYLDREWEEEPLSTATFYFLLPSCLFAMPPEVKGPSGMACVLGIHWTRSHNFFLYSLNRTLKDKADPEGVWPC
AAPIAVSQLSCSSSYLVLACEDGVLTLWDLAKGFPLGVAALPQGCFCQSIHFLKYFSVHKGQNMYPEGQVKSQMKCVVLCTDASLHLVEA
SGTQGPTISVLVERPVKHLDKTICAVAPVPALPGMVLIFSKNGSVCLMDVAKREIICAFAPPGAFPLEVPWKPVFAVSPDHPCFLLRGDY
SHETASTDDAGIQYSVFYFNFEACPLLENISKNCTIPQRDLDNMAFPQALPLEKRCERFLQKSYRKLEKNPEKEEEHWARLQRYSLSLQR

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>84901_84901_4_SNX18-WDR93_SNX18_chr5_53815403_ENST00000381410_WDR93_chr15_90270388_ENST00000560294_length(transcript)=3155nt_BP=1811nt
GGCGCTGCGAAGTGGAGGCGCTGCGAGCGGAGCCGCGCGGAGGGCGCGACCGGCTGGTCCGGGCAGCGTGGGTTTGCCGCCTTCGGGGCT
CCAGTCCGCGCGCCAGGGCTCGAGCAGTACCGCGGGCCCCTCAGGTGGGCCTCGGCTCGGGACGCCGGGAGTCGGGACCGCCAGTCGGGG
CGCCGGGACCATGGCGCTGCGCGCCCGGGCGCTGTACGACTTCAGGTCGGAGAACCCAGGAGAGATCTCGCTGCGAGAGCACGAGGTGCT
GAGCCTGTGCAGCGAGCAGGACATCGAGGGCTGGCTCGAGGGGGTCAACAGCCGCGGCGACCGCGGCCTCTTCCCGGCCTCCTATGTGCA
GGTGATCCGCGCCCCCGAGCCTGGCCCGGCGGGAGACGGCGGCCCGGGCGCCCCGGCCCGCTACGCCAATGTGCCCCCCGGGGGCTTCGA
GCCCCTGCCTGTCGCGCCCCCCGCCTCCTTCAAGCCGCCGCCTGACGCCTTCCAGGCGCTGCTGCAGCCACAGCAGGCGCCGCCTCCGAG
CACCTTCCAGCCGCCCGGCGCGGGCTTCCCGTACGGCGGGGGCGCCCTGCAGCCGTCGCCTCAGCAGCTCTACGGCGGCTACCAGGCCAG
CCAAGGCAGCGATGATGACTGGGACGACGAGTGGGACGACAGCTCCACGGTGGCGGACGAGCCGGGCGCTCTGGGCAGCGGAGCATACCC
GGACCTCGACGGCTCGTCTTCGGCGGGTGTGGGCGCAGCCGGCCGCTACCGCCTGTCCACGCGCTCCGACCTGTCCCTGGGTTCCCGCGG
CGGCTCGGTCCCCCCGCAGCACCACCCGTCGGGGCCCAAGAGCTCGGCCACCGTGAGCCGCAACCTCAATCGCTTCTCCACCTTCGTCAA
GTCCGGCGGGGAGGCCTTCGTGCTGGGGGAGGCGTCAGGCTTCGTGAAGGACGGGGACAAGCTGTGCGTGGTGCTGGGGCCCTATGGCCC
CGAGTGGCAGGAGAACCCCTACCCGTTCCAGTGCACCATCGACGACCCCACCAAGCAGACCAAGTTCAAGGGCATGAAGAGCTACATCTC
CTACAAGCTGGTGCCCACGCACACGCAGGTGCCGGTGCATCGGCGCTACAAGCACTTCGACTGGCTGTACGCGCGCCTGGCGGAGAAGTT
CCCGGTCATCTCCGTGCCCCACCTGCCCGAGAAGCAGGCCACCGGCCGCTTCGAGGAGGACTTCATCTCTAAGCGCAGGAAGGGCCTGAT
CTGGTGGATGAACCACATGGCCAGCCACCCAGTGCTGGCGCAGTGCGACGTCTTCCAGCACTTCCTGACGTGCCCCAGCAGCACCGACGA
GAAAGCCTGGAAGCAGGGCAAGAGGAAGGCCGAGAAGGACGAGATGGTGGGCGCCAACTTCTTCCTGACCCTTAGCACGCCCCCCGCCGC
TGCCCTTGACCTGCAGGAGGTGGAGAGCAAGATCGACGGCTTCAAGTGCTTCACCAAGAAGATGGACGACAGCGCGCTGCAGCTCAACCA
CACGGCCAACGAGTTCGCGCGCAAGCAGGTGACCGGCTTCAAAAAGGAGTATCAGAAGGTGGGCCAGTCCTTCCGCGGCCTCAGCCAGGC
CTTTGAGCTGGACCAGCAGGCCTTCTCGGTGGGCCTGAACCAGGCTATCGCCTTCACCGGAGATGCCTATGACGCCATTGGCGAGCTCTT
CGCGGAGCAGCCCAGGCAGGACCTGGATCCCGTCATGGACCTATTAGCGCTGTATCAGGGGCATCTGGCTAACTTCCCGGACATCATCCA
CGTTCAGAAAGGCACCACATTCAAAAGCCCCCTGGAAGTCTTTGCAAAGATCAAGGACTGCTACGGACTGGGCTCCGGGCAGAATCATTT
CATCAAGGACAGTCAGTGGGAGCAGCAAGCTGAGATCTTCAACGCTTCCTACAAGAAGTACCTAGATAGGGAGTGGGAGGAAGAGCCACT
CAGTACGGCCACCTTCTATTTCCTTCTTCCTAGCTGCCTATTTGCAATGCCACCGGAAGTCAAGGGCCCCTCAGGAATGGCCTGTGTCCT
TGGTATACACTGGACCAGAAGTCACAATTTCTTCCTGTATTCACTAAACCGAACTCTAAAGGATAAAGCTGACCCCGAGGGTGTGTGGCC
CTGTGCTGCGCCCATTGCAGTCTCTCAGCTCAGCTGCTCCTCCTCCTACCTGGTGCTGGCCTGCGAGGATGGTGTGCTCACGCTGTGGGA
CCTGGCCAAAGGACAGAATATGTATCCTGAAGGTCAAGTGAAATCCCAAATGAAATGTGTGGTGCTGTGCACAGACGCCTCCCTCCATCT
GGTGGAGGCTAGCGGGACCCAAGGACCCACCATCAGTGTGCTTGTTGAGAGGCCTGTAAAGCACCTGGATAAAACCATCTGTGCCGTGGC
CCCAGTCCCAGCCTTACCTGGCATGGTGCTCATCTTTTCCAAGAATGGCTCTGTGTGCCTTATGGATGTGGCCAAGCGTGAAATCATCTG
TGCCTTTGCCCCTCCGGGAGCCTTTCCTCTGGAGGTCCCCTGGAAGCCAGTGTTTGCTGTGTCTCCAGACCATCCATGTTTCCTGCTCCG
AGGAGACTATTCACATGAAACTGCGTCCACCGACGATGCTGGAATCCAATATTCTGTTTTCTATTTTAATTTTGAGGCCTGCCCACTCCT
GGAAAATATCTCAAAAAATTGTACCATTCCTCAAAGGGACTTGGATAACATGGCCTTCCCCCAAGCACTGCCACTGGAGAAGAGATGTGA
GCGTTTCCTCCAGAAGAGCTATCGGAAGCTGGAGAAGAACCCAGAGAAGGAGGAGGAGCACTGGGCCCGGCTTCAGAGGTACTCCTTGTC
GCTCCAGAGAGAGAACTTCAAGAAGTGAGGCTGCCACCGCCCTGGGATCTCTGAAAAGGAGGTTTCAGCCACGAGGCAGCTGCTCCCAGG
ACACTGAGGCCAAGAGAAATGTAACAGAGCCACAGCTCCACAGGCCTGCACTCGGAGTCTGGGGCCTCTGCAGAGCCAGCAAGGGGAAAA
GTATAATCTGGGGGACCTTCAACCACTAAGCCTCTTGTCAGAGCCCTCAGGCAGGCAGATGTGTCACCCAAATAAACAGTGATATTGTCT

>84901_84901_4_SNX18-WDR93_SNX18_chr5_53815403_ENST00000381410_WDR93_chr15_90270388_ENST00000560294_length(amino acids)=967AA_BP=602
MRSGGAASGAARRARPAGPGSVGLPPSGLQSARQGSSSTAGPSGGPRLGTPGVGTASRGAGTMALRARALYDFRSENPGEISLREHEVLS
LCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPST
FQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGG
SVPPQHHPSGPKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISY
KLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEK
AWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAF
ELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGTTFKSPLEVFAKIKDCYGLGSGQNHFI
KDSQWEQQAEIFNASYKKYLDREWEEEPLSTATFYFLLPSCLFAMPPEVKGPSGMACVLGIHWTRSHNFFLYSLNRTLKDKADPEGVWPC
AAPIAVSQLSCSSSYLVLACEDGVLTLWDLAKGQNMYPEGQVKSQMKCVVLCTDASLHLVEASGTQGPTISVLVERPVKHLDKTICAVAP
VPALPGMVLIFSKNGSVCLMDVAKREIICAFAPPGAFPLEVPWKPVFAVSPDHPCFLLRGDYSHETASTDDAGIQYSVFYFNFEACPLLE

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Top

Fusion Gene PPI Analysis for SNX18-WDR93

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SNX18-WDR93

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SNX18-WDR93

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source