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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SNX5-EIF3C (FusionGDB2 ID:85009)

Fusion Gene Summary for SNX5-EIF3C

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX5-EIF3C
Fusion gene ID: 85009
HgeneTgene
Gene symbol

SNX5

EIF3C

Gene ID

27131

8663

Gene namesorting nexin 5eukaryotic translation initiation factor 3 subunit C
Synonyms-EIF3CL|EIF3S8|eIF3-p110
Cytomap

20p11.23

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-5eukaryotic translation initiation factor 3 subunit Ccell migration-inducing protein 17eIF3 p110eukaryotic translation initiation factor 3 subunit 8eukaryotic translation initiation factor 3, subunit 8 (110kD)eukaryotic translation initiation factor 3
Modification date2020032020200322
UniProtAcc.

B5ME19

Ensembl transtripts involved in fusion geneENST00000377759, ENST00000377768, 
ENST00000481323, ENST00000486039, 
ENST00000606602, ENST00000483485, 
ENST00000606557, 		ENST00000565099, 
ENST00000331666, ENST00000395587, 
ENST00000564243, ENST00000566501, 
ENST00000566866, 
Fusion gene scores* DoF score8 X 8 X 5=3208 X 8 X 3=192
# samples 88
** MAII scorelog2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNX5 [Title/Abstract] AND EIF3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSNX5(17949017)-EIF3C(28737925), # samples:1
Anticipated loss of major functional domain due to fusion event.SNX5-EIF3C seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SNX5-EIF3C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNX5

GO:0006907

pinocytosis

18854019

TgeneEIF3C

GO:0006413

translational initiation

17581632


check buttonFusion gene breakpoints across SNX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1733SNX5chr20

17949017

-EIF3Cchr16

28737925

+


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Fusion Gene ORF analysis for SNX5-EIF3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377759ENST00000565099SNX5chr20

17949017

-EIF3Cchr16

28737925

+
5CDS-intronENST00000377768ENST00000565099SNX5chr20

17949017

-EIF3Cchr16

28737925

+
5CDS-intronENST00000481323ENST00000565099SNX5chr20

17949017

-EIF3Cchr16

28737925

+
5CDS-intronENST00000486039ENST00000565099SNX5chr20

17949017

-EIF3Cchr16

28737925

+
5CDS-intronENST00000606602ENST00000565099SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000377759ENST00000331666SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000377759ENST00000395587SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000377759ENST00000564243SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000377759ENST00000566501SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000377759ENST00000566866SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000481323ENST00000331666SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000481323ENST00000395587SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000481323ENST00000564243SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000481323ENST00000566501SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000481323ENST00000566866SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000486039ENST00000331666SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000486039ENST00000395587SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000486039ENST00000564243SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000486039ENST00000566501SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000486039ENST00000566866SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000606602ENST00000331666SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000606602ENST00000395587SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000606602ENST00000564243SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000606602ENST00000566501SNX5chr20

17949017

-EIF3Cchr16

28737925

+
Frame-shiftENST00000606602ENST00000566866SNX5chr20

17949017

-EIF3Cchr16

28737925

+
In-frameENST00000377768ENST00000331666SNX5chr20

17949017

-EIF3Cchr16

28737925

+
In-frameENST00000377768ENST00000395587SNX5chr20

17949017

-EIF3Cchr16

28737925

+
In-frameENST00000377768ENST00000564243SNX5chr20

17949017

-EIF3Cchr16

28737925

+
In-frameENST00000377768ENST00000566501SNX5chr20

17949017

-EIF3Cchr16

28737925

+
In-frameENST00000377768ENST00000566866SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000483485ENST00000331666SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000483485ENST00000395587SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000483485ENST00000564243SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000483485ENST00000566501SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000483485ENST00000566866SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000606557ENST00000331666SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000606557ENST00000395587SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000606557ENST00000564243SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000606557ENST00000566501SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-3CDSENST00000606557ENST00000566866SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-intronENST00000483485ENST00000565099SNX5chr20

17949017

-EIF3Cchr16

28737925

+
intron-intronENST00000606557ENST00000565099SNX5chr20

17949017

-EIF3Cchr16

28737925

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377768SNX5chr2017949017-ENST00000566501EIF3Cchr1628737925+17893643781703441
ENST00000377768SNX5chr2017949017-ENST00000331666EIF3Cchr1628737925+19213643781703441
ENST00000377768SNX5chr2017949017-ENST00000395587EIF3Cchr1628737925+19183643781703441
ENST00000377768SNX5chr2017949017-ENST00000564243EIF3Cchr1628737925+17873643781703441
ENST00000377768SNX5chr2017949017-ENST00000566866EIF3Cchr1628737925+17883643781703441

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377768ENST00000566501SNX5chr2017949017-EIF3Cchr1628737925+0.0180473330.9819527
ENST00000377768ENST00000331666SNX5chr2017949017-EIF3Cchr1628737925+0.0143986020.98560137
ENST00000377768ENST00000395587SNX5chr2017949017-EIF3Cchr1628737925+0.0144484510.9855516
ENST00000377768ENST00000564243SNX5chr2017949017-EIF3Cchr1628737925+0.0182591430.98174083
ENST00000377768ENST00000566866SNX5chr2017949017-EIF3Cchr1628737925+0.018020150.98197985

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Fusion Genomic Features for SNX5-EIF3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SNX5chr2017949017-EIF3Cchr1628737925+7.84E-121
SNX5chr2017949017-EIF3Cchr1628737925+7.84E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SNX5-EIF3C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:17949017/chr16:28737925)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF3C

B5ME19

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003316661221673_849467914.0DomainPCI
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003955871221673_849467914.0DomainPCI
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005665011221673_849467914.0DomainPCI
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005668661120673_849467914.0DomainPCI

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX5chr20:17949017chr16:28737925ENST00000377759-113202_40417405.0DomainNote=BAR
HgeneSNX5chr20:17949017chr16:28737925ENST00000377759-11325_17217405.0DomainPX
HgeneSNX5chr20:17949017chr16:28737925ENST00000377768-214202_40417405.0DomainNote=BAR
HgeneSNX5chr20:17949017chr16:28737925ENST00000377768-21425_17217405.0DomainPX
HgeneSNX5chr20:17949017chr16:28737925ENST00000377759-113113_11617405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17949017chr16:28737925ENST00000377759-113183_20017405.0RegionMembrane-binding amphipathic helix
HgeneSNX5chr20:17949017chr16:28737925ENST00000377759-11340_4617405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17949017chr16:28737925ENST00000377759-11399_10517405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17949017chr16:28737925ENST00000377768-214113_11617405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17949017chr16:28737925ENST00000377768-214183_20017405.0RegionMembrane-binding amphipathic helix
HgeneSNX5chr20:17949017chr16:28737925ENST00000377768-21440_4617405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17949017chr16:28737925ENST00000377768-21499_10517405.0RegionPhosphatidylinositol bisphosphate binding
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003316661221164_189467914.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003316661221243_246467914.0Compositional biasNote=Poly-Glu
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003316661221291_294467914.0Compositional biasNote=Poly-Glu
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003955871221164_189467914.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003955871221243_246467914.0Compositional biasNote=Poly-Glu
TgeneEIF3Cchr20:17949017chr16:28737925ENST000003955871221291_294467914.0Compositional biasNote=Poly-Glu
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005665011221164_189467914.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005665011221243_246467914.0Compositional biasNote=Poly-Glu
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005665011221291_294467914.0Compositional biasNote=Poly-Glu
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005668661120164_189467914.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005668661120243_246467914.0Compositional biasNote=Poly-Glu
TgeneEIF3Cchr20:17949017chr16:28737925ENST000005668661120291_294467914.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for SNX5-EIF3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85009_85009_1_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000331666_length(transcript)=1921nt_BP=364nt
GGCCTCCGCCAACGCGCCACCAGTTAGAGGCAGGGAGTACCTCTCCGAGCGGAAGGGCCGGCGTCTCCGAAGCGCGGGAGCCTCCAAATC
GCGCCCTTCTGCTCTCACGAGATCTGGTGACGTCAGCGCTCGCTGCCATCTTGGACTCGGGCTGAGTAATAAATTCCCCCCGCACCGAAA
CGCGGTCTTTCTCTAGACGCGTCTTGCTGGGAGAGTGTCCGTTGCTTCCCGTCCGTGTCGCGGCCCTGCGGTTGGCGGCCTCCTCGTGGA
GCGGAGCAAGGCCAGGCGGCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAG
CAAGAGTACGTGGAGCACTTGAAGGATGAGGCCCAGGTGTGTGCCATCATCGAGCGTGTGCAGCGCTACCTGGAGGAGAAGGGCACTACC
GAGGAGGTCTGCCGCATCTACCTGCTGCGCATCCTGCACACCTACTACAAGTTTGATTACAAGGCCCATCAGCGACAGCTGACCCCGCCT
GAGGGCTCCTCAAAGTCTGAGCAAGACCAGGCAGAAAATGAGGGCGAGGACTCGGCTGTGTTGATGGAGAGACTGTGCAAGTACATCTAC
GCCAAGGACCGCACAGACCGGATCCGCACATGTGCCATCCTCTGCCACATCTACCACCATGCTCTGCACTCGCGCTGGTACCAGGCCCGC
GACCTCATGCTCATGAGCCACTTGCAGGACAACATTCAGCATGCAGACCCGCCAGTGCAGATCCTTTACAACCGCACCATGGTGCAGCTG
GGCATCTGTGCCTTCCGCCAAGGCCTGACCAAGGACGCACACAACGCCCTGCTGGACATCCAGTCGAGTGGCCGAGCCAAGGAGCTTCTG
GGCCAGGGCCTGCTGCTGCGCAGCCTGCAGGAGCGCAACCAGGAGCAGGAGAAGGTGGAGCGGCGCCGTCAGGTCCCCTTCCACCTGCAC
ATCAACCTGGAGCTGCTGGAGTGTGTCTACCTGGTGTCTGCCATGCTCCTGGAGATCCCCTACATGGCCGCCCATGAGAGCGATGCCCGC
CGACGCATGATCAGCAAGCAGTTCCACCACCAGCTGCGCGTGGGCGAGCGACAGCCCCTGCTGGGTCCCCCTGAGTCCATGCGGGAACAT
GTGGTCGCTGCCTCCAAGGCCATGAAGATGGGTGACTGGAAGACCTGTCACAGTTTTATCATCAATGAGAAGATGAATGGGAAAGTGTGG
GACCTTTTCCCCGAGGCTGACAAAGTCCGCACCATGCTGGTTAGGAAGATCCAGGAAGAGTCACTGAGGACCTACCTCTTCACCTACAGC
AGTGTCTATGACTCCATCAGCATGGAGACGCTGTCAGACATGTTTGAGCTGGATCTGCCCACTGTGCACTCCATCATCAGCAAAATGATC
ATTAATGAGGAGCTGATGGCCTCCCTGGACCAGCCAACACAGACAGTGGTGATGCACCGCACTGAGCCCACTGCCCAGCAGAACCTGGCT
CTGCAGCTGGCCGAGAAGCTGGGCAGCCTGGTGGAGAACAACGAACGGGTGTTTGACCACAAGCAGGGCACCTACGGGGGCTACTTCCGA
GACCAGAAGGACGGCTACCGCAAAAACGAGGGCTACATGCGCCGCGGTGGCTACCGCCAGCAGCAGTCTCAGACGGCCTACTGAGCTCTC
CACTCTGTTTCCCGCCTGGGCCATCCAACCTTGAAGTCCTAAACCACACCTCAGTCACTAAAGGTCTGTTTAAAGTTGTTCTGGTTGATT
GCTTGTTGCCACAAAGGTGTGTTGAGCCCATTCATTTGCTGATTATATTTCTGAGCTGCTACCACATGACAGACACAAGGCTCAGATGAA

>85009_85009_1_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000331666_length(amino acids)=441AA_BP=
MKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTD
RIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLL
RSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASK
AMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELM

--------------------------------------------------------------
>85009_85009_2_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000395587_length(transcript)=1918nt_BP=364nt
GGCCTCCGCCAACGCGCCACCAGTTAGAGGCAGGGAGTACCTCTCCGAGCGGAAGGGCCGGCGTCTCCGAAGCGCGGGAGCCTCCAAATC
GCGCCCTTCTGCTCTCACGAGATCTGGTGACGTCAGCGCTCGCTGCCATCTTGGACTCGGGCTGAGTAATAAATTCCCCCCGCACCGAAA
CGCGGTCTTTCTCTAGACGCGTCTTGCTGGGAGAGTGTCCGTTGCTTCCCGTCCGTGTCGCGGCCCTGCGGTTGGCGGCCTCCTCGTGGA
GCGGAGCAAGGCCAGGCGGCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAG
CAAGAGTACGTGGAGCACTTGAAGGATGAGGCCCAGGTGTGTGCCATCATCGAGCGTGTGCAGCGCTACCTGGAGGAGAAGGGCACTACC
GAGGAGGTCTGCCGCATCTACCTGCTGCGCATCCTGCACACCTACTACAAGTTTGATTACAAGGCCCATCAGCGACAGCTGACCCCGCCT
GAGGGCTCCTCAAAGTCTGAGCAAGACCAGGCAGAAAATGAGGGCGAGGACTCGGCTGTGTTGATGGAGAGACTGTGCAAGTACATCTAC
GCCAAGGACCGCACAGACCGGATCCGCACATGTGCCATCCTCTGCCACATCTACCACCATGCTCTGCACTCGCGCTGGTACCAGGCCCGC
GACCTCATGCTCATGAGCCACTTGCAGGACAACATTCAGCATGCAGACCCGCCAGTGCAGATCCTTTACAACCGCACCATGGTGCAGCTG
GGCATCTGTGCCTTCCGCCAAGGCCTGACCAAGGACGCACACAACGCCCTGCTGGACATCCAGTCGAGTGGCCGAGCCAAGGAGCTTCTG
GGCCAGGGCCTGCTGCTGCGCAGCCTGCAGGAGCGCAACCAGGAGCAGGAGAAGGTGGAGCGGCGCCGTCAGGTCCCCTTCCACCTGCAC
ATCAACCTGGAGCTGCTGGAGTGTGTCTACCTGGTGTCTGCCATGCTCCTGGAGATCCCCTACATGGCCGCCCATGAGAGCGATGCCCGC
CGACGCATGATCAGCAAGCAGTTCCACCACCAGCTGCGCGTGGGCGAGCGACAGCCCCTGCTGGGTCCCCCTGAGTCCATGCGGGAACAT
GTGGTCGCTGCCTCCAAGGCCATGAAGATGGGTGACTGGAAGACCTGTCACAGTTTTATCATCAATGAGAAGATGAATGGGAAAGTGTGG
GACCTTTTCCCCGAGGCTGACAAAGTCCGCACCATGCTGGTTAGGAAGATCCAGGAAGAGTCACTGAGGACCTACCTCTTCACCTACAGC
AGTGTCTATGACTCCATCAGCATGGAGACGCTGTCAGACATGTTTGAGCTGGATCTGCCCACTGTGCACTCCATCATCAGCAAAATGATC
ATTAATGAGGAGCTGATGGCCTCCCTGGACCAGCCAACACAGACAGTGGTGATGCACCGCACTGAGCCCACTGCCCAGCAGAACCTGGCT
CTGCAGCTGGCCGAGAAGCTGGGCAGCCTGGTGGAGAACAACGAACGGGTGTTTGACCACAAGCAGGGCACCTACGGGGGCTACTTCCGA
GACCAGAAGGACGGCTACCGCAAAAACGAGGGCTACATGCGCCGCGGTGGCTACCGCCAGCAGCAGTCTCAGACGGCCTACTGAGCTCTC
CACTCTGTTTCCCGCCTGGGCCATCCAACCTTGAAGTCCTAAACCACACCTCAGTCACTAAAGGTCTGTTTAAAGTTGTTCTGGTTGATT
GCTTGTTGCCACAAAGGTGTGTTGAGCCCATTCATTTGCTGATTATATTTCTGAGCTGCTACCACATGACAGACACAAGGCTCAGATGAA

>85009_85009_2_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000395587_length(amino acids)=441AA_BP=
MKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTD
RIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLL
RSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASK
AMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELM

--------------------------------------------------------------
>85009_85009_3_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000564243_length(transcript)=1787nt_BP=364nt
GGCCTCCGCCAACGCGCCACCAGTTAGAGGCAGGGAGTACCTCTCCGAGCGGAAGGGCCGGCGTCTCCGAAGCGCGGGAGCCTCCAAATC
GCGCCCTTCTGCTCTCACGAGATCTGGTGACGTCAGCGCTCGCTGCCATCTTGGACTCGGGCTGAGTAATAAATTCCCCCCGCACCGAAA
CGCGGTCTTTCTCTAGACGCGTCTTGCTGGGAGAGTGTCCGTTGCTTCCCGTCCGTGTCGCGGCCCTGCGGTTGGCGGCCTCCTCGTGGA
GCGGAGCAAGGCCAGGCGGCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAG
CAAGAGTACGTGGAGCACTTGAAGGATGAGGCCCAGGTGTGTGCCATCATCGAGCGTGTGCAGCGCTACCTGGAGGAGAAGGGCACTACC
GAGGAGGTCTGCCGCATCTACCTGCTGCGCATCCTGCACACCTACTACAAGTTTGATTACAAGGCCCATCAGCGACAGCTGACCCCGCCT
GAGGGCTCCTCAAAGTCTGAGCAAGACCAGGCAGAAAATGAGGGCGAGGACTCGGCTGTGTTGATGGAGAGACTGTGCAAGTACATCTAC
GCCAAGGACCGCACAGACCGGATCCGCACATGTGCCATCCTCTGCCACATCTACCACCATGCTCTGCACTCGCGCTGGTACCAGGCCCGC
GACCTCATGCTCATGAGCCACTTGCAGGACAACATTCAGCATGCAGACCCGCCAGTGCAGATCCTTTACAACCGCACCATGGTGCAGCTG
GGCATCTGTGCCTTCCGCCAAGGCCTGACCAAGGACGCACACAACGCCCTGCTGGACATCCAGTCGAGTGGCCGAGCCAAGGAGCTTCTG
GGCCAGGGCCTGCTGCTGCGCAGCCTGCAGGAGCGCAACCAGGAGCAGGAGAAGGTGGAGCGGCGCCGTCAGGTCCCCTTCCACCTGCAC
ATCAACCTGGAGCTGCTGGAGTGTGTCTACCTGGTGTCTGCCATGCTCCTGGAGATCCCCTACATGGCCGCCCATGAGAGCGATGCCCGC
CGACGCATGATCAGCAAGCAGTTCCACCACCAGCTGCGCGTGGGCGAGCGACAGCCCCTGCTGGGTCCCCCTGAGTCCATGCGGGAACAT
GTGGTCGCTGCCTCCAAGGCCATGAAGATGGGTGACTGGAAGACCTGTCACAGTTTTATCATCAATGAGAAGATGAATGGGAAAGTGTGG
GACCTTTTCCCCGAGGCTGACAAAGTCCGCACCATGCTGGTTAGGAAGATCCAGGAAGAGTCACTGAGGACCTACCTCTTCACCTACAGC
AGTGTCTATGACTCCATCAGCATGGAGACGCTGTCAGACATGTTTGAGCTGGATCTGCCCACTGTGCACTCCATCATCAGCAAAATGATC
ATTAATGAGGAGCTGATGGCCTCCCTGGACCAGCCAACACAGACAGTGGTGATGCACCGCACTGAGCCCACTGCCCAGCAGAACCTGGCT
CTGCAGCTGGCCGAGAAGCTGGGCAGCCTGGTGGAGAACAACGAACGGGTGTTTGACCACAAGCAGGGCACCTACGGGGGCTACTTCCGA
GACCAGAAGGACGGCTACCGCAAAAACGAGGGCTACATGCGCCGCGGTGGCTACCGCCAGCAGCAGTCTCAGACGGCCTACTGAGCTCTC

>85009_85009_3_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000564243_length(amino acids)=441AA_BP=
MKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTD
RIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLL
RSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASK
AMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELM

--------------------------------------------------------------
>85009_85009_4_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000566501_length(transcript)=1789nt_BP=364nt
GGCCTCCGCCAACGCGCCACCAGTTAGAGGCAGGGAGTACCTCTCCGAGCGGAAGGGCCGGCGTCTCCGAAGCGCGGGAGCCTCCAAATC
GCGCCCTTCTGCTCTCACGAGATCTGGTGACGTCAGCGCTCGCTGCCATCTTGGACTCGGGCTGAGTAATAAATTCCCCCCGCACCGAAA
CGCGGTCTTTCTCTAGACGCGTCTTGCTGGGAGAGTGTCCGTTGCTTCCCGTCCGTGTCGCGGCCCTGCGGTTGGCGGCCTCCTCGTGGA
GCGGAGCAAGGCCAGGCGGCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAG
CAAGAGTACGTGGAGCACTTGAAGGATGAGGCCCAGGTGTGTGCCATCATCGAGCGTGTGCAGCGCTACCTGGAGGAGAAGGGCACTACC
GAGGAGGTCTGCCGCATCTACCTGCTGCGCATCCTGCACACCTACTACAAGTTTGATTACAAGGCCCATCAGCGACAGCTGACCCCGCCT
GAGGGCTCCTCAAAGTCTGAGCAAGACCAGGCAGAAAATGAGGGCGAGGACTCGGCTGTGTTGATGGAGAGACTGTGCAAGTACATCTAC
GCCAAGGACCGCACAGACCGGATCCGCACATGTGCCATCCTCTGCCACATCTACCACCATGCTCTGCACTCGCGCTGGTACCAGGCCCGC
GACCTCATGCTCATGAGCCACTTGCAGGACAACATTCAGCATGCAGACCCGCCAGTGCAGATCCTTTACAACCGCACCATGGTGCAGCTG
GGCATCTGTGCCTTCCGCCAAGGCCTGACCAAGGACGCACACAACGCCCTGCTGGACATCCAGTCGAGTGGCCGAGCCAAGGAGCTTCTG
GGCCAGGGCCTGCTGCTGCGCAGCCTGCAGGAGCGCAACCAGGAGCAGGAGAAGGTGGAGCGGCGCCGTCAGGTCCCCTTCCACCTGCAC
ATCAACCTGGAGCTGCTGGAGTGTGTCTACCTGGTGTCTGCCATGCTCCTGGAGATCCCCTACATGGCCGCCCATGAGAGCGATGCCCGC
CGACGCATGATCAGCAAGCAGTTCCACCACCAGCTGCGCGTGGGCGAGCGACAGCCCCTGCTGGGTCCCCCTGAGTCCATGCGGGAACAT
GTGGTCGCTGCCTCCAAGGCCATGAAGATGGGTGACTGGAAGACCTGTCACAGTTTTATCATCAATGAGAAGATGAATGGGAAAGTGTGG
GACCTTTTCCCCGAGGCTGACAAAGTCCGCACCATGCTGGTTAGGAAGATCCAGGAAGAGTCACTGAGGACCTACCTCTTCACCTACAGC
AGTGTCTATGACTCCATCAGCATGGAGACGCTGTCAGACATGTTTGAGCTGGATCTGCCCACTGTGCACTCCATCATCAGCAAAATGATC
ATTAATGAGGAGCTGATGGCCTCCCTGGACCAGCCAACACAGACAGTGGTGATGCACCGCACTGAGCCCACTGCCCAGCAGAACCTGGCT
CTGCAGCTGGCCGAGAAGCTGGGCAGCCTGGTGGAGAACAACGAACGGGTGTTTGACCACAAGCAGGGCACCTACGGGGGCTACTTCCGA
GACCAGAAGGACGGCTACCGCAAAAACGAGGGCTACATGCGCCGCGGTGGCTACCGCCAGCAGCAGTCTCAGACGGCCTACTGAGCTCTC

>85009_85009_4_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000566501_length(amino acids)=441AA_BP=
MKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTD
RIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLL
RSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASK
AMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELM

--------------------------------------------------------------
>85009_85009_5_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000566866_length(transcript)=1788nt_BP=364nt
GGCCTCCGCCAACGCGCCACCAGTTAGAGGCAGGGAGTACCTCTCCGAGCGGAAGGGCCGGCGTCTCCGAAGCGCGGGAGCCTCCAAATC
GCGCCCTTCTGCTCTCACGAGATCTGGTGACGTCAGCGCTCGCTGCCATCTTGGACTCGGGCTGAGTAATAAATTCCCCCCGCACCGAAA
CGCGGTCTTTCTCTAGACGCGTCTTGCTGGGAGAGTGTCCGTTGCTTCCCGTCCGTGTCGCGGCCCTGCGGTTGGCGGCCTCCTCGTGGA
GCGGAGCAAGGCCAGGCGGCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAG
CAAGAGTACGTGGAGCACTTGAAGGATGAGGCCCAGGTGTGTGCCATCATCGAGCGTGTGCAGCGCTACCTGGAGGAGAAGGGCACTACC
GAGGAGGTCTGCCGCATCTACCTGCTGCGCATCCTGCACACCTACTACAAGTTTGATTACAAGGCCCATCAGCGACAGCTGACCCCGCCT
GAGGGCTCCTCAAAGTCTGAGCAAGACCAGGCAGAAAATGAGGGCGAGGACTCGGCTGTGTTGATGGAGAGACTGTGCAAGTACATCTAC
GCCAAGGACCGCACAGACCGGATCCGCACATGTGCCATCCTCTGCCACATCTACCACCATGCTCTGCACTCGCGCTGGTACCAGGCCCGC
GACCTCATGCTCATGAGCCACTTGCAGGACAACATTCAGCATGCAGACCCGCCAGTGCAGATCCTTTACAACCGCACCATGGTGCAGCTG
GGCATCTGTGCCTTCCGCCAAGGCCTGACCAAGGACGCACACAACGCCCTGCTGGACATCCAGTCGAGTGGCCGAGCCAAGGAGCTTCTG
GGCCAGGGCCTGCTGCTGCGCAGCCTGCAGGAGCGCAACCAGGAGCAGGAGAAGGTGGAGCGGCGCCGTCAGGTCCCCTTCCACCTGCAC
ATCAACCTGGAGCTGCTGGAGTGTGTCTACCTGGTGTCTGCCATGCTCCTGGAGATCCCCTACATGGCCGCCCATGAGAGCGATGCCCGC
CGACGCATGATCAGCAAGCAGTTCCACCACCAGCTGCGCGTGGGCGAGCGACAGCCCCTGCTGGGTCCCCCTGAGTCCATGCGGGAACAT
GTGGTCGCTGCCTCCAAGGCCATGAAGATGGGTGACTGGAAGACCTGTCACAGTTTTATCATCAATGAGAAGATGAATGGGAAAGTGTGG
GACCTTTTCCCCGAGGCTGACAAAGTCCGCACCATGCTGGTTAGGAAGATCCAGGAAGAGTCACTGAGGACCTACCTCTTCACCTACAGC
AGTGTCTATGACTCCATCAGCATGGAGACGCTGTCAGACATGTTTGAGCTGGATCTGCCCACTGTGCACTCCATCATCAGCAAAATGATC
ATTAATGAGGAGCTGATGGCCTCCCTGGACCAGCCAACACAGACAGTGGTGATGCACCGCACTGAGCCCACTGCCCAGCAGAACCTGGCT
CTGCAGCTGGCCGAGAAGCTGGGCAGCCTGGTGGAGAACAACGAACGGGTGTTTGACCACAAGCAGGGCACCTACGGGGGCTACTTCCGA
GACCAGAAGGACGGCTACCGCAAAAACGAGGGCTACATGCGCCGCGGTGGCTACCGCCAGCAGCAGTCTCAGACGGCCTACTGAGCTCTC

>85009_85009_5_SNX5-EIF3C_SNX5_chr20_17949017_ENST00000377768_EIF3C_chr16_28737925_ENST00000566866_length(amino acids)=441AA_BP=
MKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTD
RIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLL
RSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASK
AMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SNX5-EIF3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSNX5chr20:17949017chr16:28737925ENST00000377759-113169_26117.0405.0DOCK1
HgeneSNX5chr20:17949017chr16:28737925ENST00000377768-214169_26117.0405.0DOCK1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SNX5-EIF3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SNX5-EIF3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource