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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SNX5-MATN2 (FusionGDB2 ID:85010)

Fusion Gene Summary for SNX5-MATN2

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX5-MATN2
Fusion gene ID: 85010
HgeneTgene
Gene symbol

SNX5

MATN2

Gene ID

27131

4147

Gene namesorting nexin 5matrilin 2
Synonyms--
Cytomap

20p11.23

8q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-5matrilin-2testis tissue sperm-binding protein Li 94mP
Modification date2020032020200313
UniProtAcc.

O00339

Ensembl transtripts involved in fusion geneENST00000377759, ENST00000377768, 
ENST00000483485, ENST00000481323, 
ENST00000486039, ENST00000606557, 
ENST00000606602, 		ENST00000518238, 
ENST00000520016, ENST00000522025, 
ENST00000254898, ENST00000521689, 
ENST00000524308, 
Fusion gene scores* DoF score8 X 8 X 5=32013 X 15 X 10=1950
# samples 819
** MAII scorelog2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1950*10)=-3.35940280030603
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNX5 [Title/Abstract] AND MATN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSNX5(17928129)-MATN2(98943180), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNX5

GO:0006907

pinocytosis

18854019


check buttonFusion gene breakpoints across SNX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MATN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8ERSNX5chr20

17928129

-MATN2chr8

98943180

+


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Fusion Gene ORF analysis for SNX5-MATN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377759ENST00000518238SNX5chr20

17928129

-MATN2chr8

98943180

+
5CDS-intronENST00000377759ENST00000520016SNX5chr20

17928129

-MATN2chr8

98943180

+
5CDS-intronENST00000377759ENST00000522025SNX5chr20

17928129

-MATN2chr8

98943180

+
5CDS-intronENST00000377768ENST00000518238SNX5chr20

17928129

-MATN2chr8

98943180

+
5CDS-intronENST00000377768ENST00000520016SNX5chr20

17928129

-MATN2chr8

98943180

+
5CDS-intronENST00000377768ENST00000522025SNX5chr20

17928129

-MATN2chr8

98943180

+
5UTR-3CDSENST00000483485ENST00000254898SNX5chr20

17928129

-MATN2chr8

98943180

+
5UTR-3CDSENST00000483485ENST00000521689SNX5chr20

17928129

-MATN2chr8

98943180

+
5UTR-3CDSENST00000483485ENST00000524308SNX5chr20

17928129

-MATN2chr8

98943180

+
5UTR-intronENST00000483485ENST00000518238SNX5chr20

17928129

-MATN2chr8

98943180

+
5UTR-intronENST00000483485ENST00000520016SNX5chr20

17928129

-MATN2chr8

98943180

+
5UTR-intronENST00000483485ENST00000522025SNX5chr20

17928129

-MATN2chr8

98943180

+
Frame-shiftENST00000377768ENST00000254898SNX5chr20

17928129

-MATN2chr8

98943180

+
Frame-shiftENST00000377768ENST00000521689SNX5chr20

17928129

-MATN2chr8

98943180

+
Frame-shiftENST00000377768ENST00000524308SNX5chr20

17928129

-MATN2chr8

98943180

+
In-frameENST00000377759ENST00000254898SNX5chr20

17928129

-MATN2chr8

98943180

+
In-frameENST00000377759ENST00000521689SNX5chr20

17928129

-MATN2chr8

98943180

+
In-frameENST00000377759ENST00000524308SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000481323ENST00000254898SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000481323ENST00000521689SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000481323ENST00000524308SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000486039ENST00000254898SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000486039ENST00000521689SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000486039ENST00000524308SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000606557ENST00000254898SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000606557ENST00000521689SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000606557ENST00000524308SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000606602ENST00000254898SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000606602ENST00000521689SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-3CDSENST00000606602ENST00000524308SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000481323ENST00000518238SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000481323ENST00000520016SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000481323ENST00000522025SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000486039ENST00000518238SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000486039ENST00000520016SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000486039ENST00000522025SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000606557ENST00000518238SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000606557ENST00000520016SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000606557ENST00000522025SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000606602ENST00000518238SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000606602ENST00000520016SNX5chr20

17928129

-MATN2chr8

98943180

+
intron-intronENST00000606602ENST00000522025SNX5chr20

17928129

-MATN2chr8

98943180

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377759SNX5chr2017928129-ENST00000521689MATN2chr898943180+431113737340441323
ENST00000377759SNX5chr2017928129-ENST00000254898MATN2chr898943180+510913737341041343
ENST00000377759SNX5chr2017928129-ENST00000524308MATN2chr898943180+447713737339781301

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377759ENST00000521689SNX5chr2017928129-MATN2chr898943180+0.0012403050.99875975
ENST00000377759ENST00000254898SNX5chr2017928129-MATN2chr898943180+0.0007437020.9992563
ENST00000377759ENST00000524308SNX5chr2017928129-MATN2chr898943180+0.0012419090.9987581

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Fusion Genomic Features for SNX5-MATN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SNX5chr2017928129-MATN2chr898943180+2.25E-060.99999774
SNX5chr2017928129-MATN2chr898943180+2.25E-060.99999774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SNX5-MATN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:17928129/chr8:98943180)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MATN2

O00339

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in matrix assembly. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX5chr20:17928129chr8:98943180ENST00000377759-111325_172359405.0DomainPX
HgeneSNX5chr20:17928129chr8:98943180ENST00000377768-121425_172359405.0DomainPX
HgeneSNX5chr20:17928129chr8:98943180ENST00000377759-1113113_116359405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17928129chr8:98943180ENST00000377759-1113183_200359405.0RegionMembrane-binding amphipathic helix
HgeneSNX5chr20:17928129chr8:98943180ENST00000377759-111340_46359405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17928129chr8:98943180ENST00000377759-111399_105359405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17928129chr8:98943180ENST00000377768-1214113_116359405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17928129chr8:98943180ENST00000377768-1214183_200359405.0RegionMembrane-binding amphipathic helix
HgeneSNX5chr20:17928129chr8:98943180ENST00000377768-121440_46359405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17928129chr8:98943180ENST00000377768-121499_105359405.0RegionPhosphatidylinositol bisphosphate binding
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018917_95547957.0Coiled coilOntology_term=ECO:0000255
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119917_95547938.0Coiled coilOntology_term=ECO:0000255
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018917_9550673.0Coiled coilOntology_term=ECO:0000255
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118917_95547916.0Coiled coilOntology_term=ECO:0000255
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018238_27847957.0DomainEGF-like 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018279_31947957.0DomainEGF-like 2
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018320_36047957.0DomainEGF-like 3
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018402_44247957.0DomainEGF-like 5
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018443_48347957.0DomainEGF-like 6
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018484_52447957.0DomainEGF-like 7
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018525_56547957.0DomainEGF-like 8
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018566_60647957.0DomainEGF-like 9
TgeneMATN2chr20:17928129chr8:98943180ENST0000052001601857_23247957.0DomainVWFA 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018607_64747957.0DomainEGF-like 10
TgeneMATN2chr20:17928129chr8:98943180ENST00000520016018655_83047957.0DomainVWFA 2
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119238_27847938.0DomainEGF-like 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119279_31947938.0DomainEGF-like 2
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119320_36047938.0DomainEGF-like 3
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119402_44247938.0DomainEGF-like 5
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119443_48347938.0DomainEGF-like 6
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119484_52447938.0DomainEGF-like 7
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119525_56547938.0DomainEGF-like 8
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119566_60647938.0DomainEGF-like 9
TgeneMATN2chr20:17928129chr8:98943180ENST0000052168911957_23247938.0DomainVWFA 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119607_64747938.0DomainEGF-like 10
TgeneMATN2chr20:17928129chr8:98943180ENST00000521689119655_83047938.0DomainVWFA 2
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018238_2780673.0DomainEGF-like 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018279_3190673.0DomainEGF-like 2
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018320_3600673.0DomainEGF-like 3
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018402_4420673.0DomainEGF-like 5
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018443_4830673.0DomainEGF-like 6
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018484_5240673.0DomainEGF-like 7
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018525_5650673.0DomainEGF-like 8
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018566_6060673.0DomainEGF-like 9
TgeneMATN2chr20:17928129chr8:98943180ENST0000052202501857_2320673.0DomainVWFA 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018607_6470673.0DomainEGF-like 10
TgeneMATN2chr20:17928129chr8:98943180ENST00000522025018655_8300673.0DomainVWFA 2
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118238_27847916.0DomainEGF-like 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118279_31947916.0DomainEGF-like 2
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118320_36047916.0DomainEGF-like 3
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118402_44247916.0DomainEGF-like 5
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118443_48347916.0DomainEGF-like 6
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118484_52447916.0DomainEGF-like 7
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118525_56547916.0DomainEGF-like 8
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118566_60647916.0DomainEGF-like 9
TgeneMATN2chr20:17928129chr8:98943180ENST0000052430811857_23247916.0DomainVWFA 1
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118607_64747916.0DomainEGF-like 10
TgeneMATN2chr20:17928129chr8:98943180ENST00000524308118655_83047916.0DomainVWFA 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX5chr20:17928129chr8:98943180ENST00000377759-1113202_404359405.0DomainNote=BAR
HgeneSNX5chr20:17928129chr8:98943180ENST00000377768-1214202_404359405.0DomainNote=BAR


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Fusion Gene Sequence for SNX5-MATN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85010_85010_1_SNX5-MATN2_SNX5_chr20_17928129_ENST00000377759_MATN2_chr8_98943180_ENST00000254898_length(transcript)=5109nt_BP=1373nt
TCCTCGTGGAGCGGAGCAAGGGTAGGCCCCACGTGGCGTCTTTGCCCGGCTCCAAGATGGACGGCAGCGGGGACTGGGAGGCTGCTCTGG
GGGAGCACGTGGCGCCCTGCTCGCCTGCTCCCGGGGCAGCTGGGATGGTGGCGGAGTCCGGAGGCCTCCTGCCGCCGTCGGGCAGGGAGG
CCGGCGGAGGCGGGGCCGTGGCCGCCCCCGAGAGGCGCCCAGGCGGCGGCGGCGGCGGCCCAGCTTCTTCTTTCCTCGCACAGCCAGGCG
GCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAGCAAGCTGAGATCTGTATC
TGTGGACCTGAATGTTGATCCCTCGCTTCAGATTGACATACCTGATGCGCTCAGTGAGAGAGACAAAGTCAAATTTACAGTGCACACAAA
GACCACACTGCCCACGTTTCAGAGCCCAGAGTTTTCTGTTACAAGGCAACATGAAGACTTTGTGTGGCTACATGACACTCTTATTGAAAC
AACAGACTATGCTGGGCTTATTATTCCACCTGCTCCTACGAAGCCCGACTTTGATGGTCCTCGAGAGAAGATGCAGAAACTGGGAGAAGG
TGAAGGGTCTATGACCAAAGAAGAATTTGCCAAGATGAAACAAGAACTGGAAGCTGAGTATCTCGCTGTGTTTAAGAAGACTGTGTCCTC
CCATGAAGTCTTTCTTCAGCGGCTTTCTTCTCACCCTGTTCTCAGTAAAGATCGCAACTTTCATGTTTTCCTGGAATATGATCAGGATCT
AAGTGTTAGGCGGAAAAATACTAAAGAGATGTTTGGTGGCTTCTTCAAAAGTGTGGTGAAAAGTGCTGATGAAGTCCTTTTTACTGGAGT
TAAGGAGGTAGATGACTTCTTTGAGCAAGAGAAGAACTTCCTTATTAACTATTACAATAGGATCAAAGATTCTTGTGTGAAAGCTGACAA
AATGACCAGATCTCATAAAAATGTTGCCGATGACTATATCCACACCGCAGCCTGCTTACATAGCCTGGCTTTAGAAGAGCCCACAGTCAT
CAAAAAGTACCTATTGAAGGTTGCTGAGCTATTTGAAAAACTAAGGAAAGTAGAGGGTCGAGTTTCATCAGATGAAGATTTGAAGCTAAC
AGAGCTCCTCCGATACTACATGCTCAACATTGAAGCTGCTAAGGATCTCTTATACAGACGCACCAAAGCCCTCATTGACTATGAGAACTC
AAACAAAGCTCTGGATAAGGCCCGGTTAAAGAGCAAAGACGTCAAGTTGGCTGAGGCACACCAGCAGGAGTGCTGCCAGAAATTTGAACA
ACTTTCCGAATCTGCAAAAGAAGAGAGTTCCTGTGAGAACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACAC
CCATGACTATGCAAAGGTCAAGGAGTTCATCGTGGACATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCA
ATATGGCAGCACTGTCAAGAATGAGTTCTCCCTCAAGACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCT
GTCCACGGGCACCATGACTGGGCTGGCCATCCAGTATGCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAA
TGTGCCACGGGTCATAATGATCGTGACAGATGGGAGACCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCT
AATCTTTGCCATTGGTGTGGGCCAGGTAGACTTCAACACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGC
CAATTTCAGCCAGATTGAGACGCTGACCTCCGTGTTCCAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGC
CCACTTCTGCATCAACATCCCTGGCTCATACGTCTGCAGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAATCCA
GGATCTGTGTGCCATGGAGGACCACAACTGTGAGCAGCTCTGTGTGAATGTGCCGGGCTCCTTCGTCTGCCAGTGCTACAGTGGCTACGC
CCTGGCTGAGGATGGGAAGAGGTGTGTGGCTGTGGACTACTGTGCCTCAGAAAACCACGGATGTGAACATGAGTGTGTAAATGCTGATGG
CTCCTACCTTTGCCAGTGCCATGAAGGATTTGCTCTTAACCCAGATAAAAAAACGTGCACAAAGATAGACTACTGTGCCTCATCTAATCA
CGGATGTCAGCACGAGTGTGTTAACACAGATGATTCCTATTCCTGCCACTGCCTGAAAGGCTTTACCCTGAATCCAGATAAGAAAACCTG
CAGAAGGATCAACTACTGTGCACTGAACAAACCGGGCTGTGAGCATGAGTGCGTCAACATGGAGGAGAGCTACTACTGCCGCTGCCACCG
TGGCTACACTCTGGACCCCAATGGCAAAACCTGCAGCCGAGTGGACCACTGTGCACAGCAGGACCATGGCTGTGAGCAGCTGTGTCTGAA
CACGGAGGATTCCTTCGTCTGCCAGTGCTCAGAAGGCTTCCTCATCAACGAGGACCTCAAGACCTGCTCCCGGGTGGATTACTGCCTGCT
GAGTGACCATGGTTGTGAATACTCCTGTGTCAACATGGACAGATCCTTTGCCTGTCAGTGTCCTGAGGGACACGTGCTCCGCAGCGATGG
GAAGACGTGTGCAAAATTGGACTCTTGTGCTCTGGGGGACCACGGTTGTGAACATTCGTGTGTAAGCAGTGAAGATTCGTTTGTGTGCCA
GTGCTTTGAAGGTTATATACTCCGTGAAGATGGAAAAACCTGCAGAAGGAAAGATGTCTGCCAAGCTATAGACCATGGCTGTGAACACAT
TTGTGTGAACAGTGATGACTCATACACGTGCGAGTGCTTGGAGGGATTCCGGCTCGCTGAGGATGGGAAACGCTGCCGAAGGAAGGATGT
CTGCAAATCAACCCACCATGGCTGCGAACACATTTGTGTTAATAATGGGAATTCCTACATCTGCAAATGCTCAGAGGGATTTGTTCTAGC
TGAGGACGGAAGACGGTGCAAGAAATGCACTGAAGGCCCAATTGACCTGGTCTTTGTGATCGATGGATCCAAGAGTCTTGGAGAAGAGAA
TTTTGAGGTCGTGAAGCAGTTTGTCACTGGAATTATAGATTCCTTGACAATTTCCCCCAAAGCCGCTCGAGTGGGGCTGCTCCAGTATTC
CACACAGGTCCACACAGAGTTCACTCTGAGAAACTTCAACTCAGCCAAAGACATGAAAAAAGCCGTGGCCCACATGAAATACATGGGAAA
GGGCTCTATGACTGGGCTGGCCCTGAAACACATGTTTGAGAGAAGTTTTACCCAAGGAGAAGGGGCCAGGCCCCTTTCCACAAGGGTGCC
CAGAGCAGCCATTGTGTTCACCGACGGACGGGCTCAGGATGACGTCTCCGAGTGGGCCAGTAAAGCCAAGGCCAATGGTATCACTATGTA
TGCTGTTGGGGTAGGAAAAGCCATTGAGGAGGAACTACAAGAGATTGCCTCTGAGCCCACAAACAAGCATCTCTTCTATGCCGAAGACTT
CAGCACAATGGATGAGATAAGTGAAAAACTCAAGAAAGGCATCTGTGAAGCTCTAGAAGACTCCGATGGAAGACAGGACTCTCCAGCAGG
GGAACTGCCAAAAACGGTCCAACAGCCAACAGAATCTGAGCCAGTCACCATAAATATCCAAGACCTACTTTCCTGTTCTAATTTTGCAGT
GCAACACAGATATCTGTTTGAAGAAGACAATCTTTTACGGTCTACACAAAAGCTTTCCCATTCAACAAAACCTTCAGGAAGCCCTTTGGA
AGAAAAACACGATCAATGCAAATGTGAAAACCTTATAATGTTCCAGAACCTTGCAAACGAAGAAGTAAGAAAATTAACACAGCGTTTACT
AGAAGAAATGACACAGAGAATGGAAGCCCTGGAAAATCGCCTGAGATACAGATGAAGATTAGAAATCGCGACACATTTGTAGTCATTGTA
TCACGGATTACAATGAACGCAGTGCAGAGCCCCAAAGCTCAGGCTATTGTTAAATCAATAATGTTGTGAAGTAAAACAATCAGTACTGAG
AAACCTGGTTTGCCACAGAACAAAGACAAGAAGTATACACTAACTTGTATAAATTTATCTAGGAAAAAAATCCTTCAGAATTCTAAGATG
AATTTACCAGGTGAGAATGAATAAGCTATGCAAGGTATTTTGTAATATACTGTGGACACAACTTGCTTCTGCCTCATCCTGCCTTAGTGT
GCAATCTCATTTGACTATACGATAAAGTTTGCACAGTCTTACTTCTGTAGAACACTGGCCATAGGAAATGCTGTTTTTTTGTACTGGACT
TTACCTTGATATATGTATATGGATGTATGCATAAAATCATAGGACATATGTACTTGTGGAACAAGTTGGATTTTTTATACAATATTAAAA
TTCACCACTTCAGAGAATGGTATTCAGTGCAAAAATTCTTAGTTTAACTTTAAATGGAAGATATGTATGTATGAGAAATGGCCAACATGC
CTATGAAAAAAATGCTGAATCTCATCAGTAATCAGGAAAATGCAGGTTAAAACAATACCATTTTTCACCCATCAGCTTAGCAAAAATGAG
TATATTTTTTAACAAGTGTTGGTAAGGATGTGGAAATGTGAGGTTCTTGTAGTAAGAATGCAAATGGCACTCTTTGTAGAGTAAGTCTGT
TGACATCTCATAAAACTGAAAATGCACACAACCCTGTAAATCTAGCAACTGCACTCAGTTGATTTCAGCCCATACATACAAAGAGACCTG
CATAAGAATGTTACTAGGCTTTGTAAAAGCAAAAAATAAGGAACAACTTAAACATCATCAGAAGGGGAACTGATAAACTCTGGTGTAATC

>85010_85010_1_SNX5-MATN2_SNX5_chr20_17928129_ENST00000377759_MATN2_chr8_98943180_ENST00000254898_length(amino acids)=1343AA_BP=433
MGGCSGGARGALLACSRGSWDGGGVRRPPAAVGQGGRRRRGRGRPREAPRRRRRRPSFFFPRTARRPLLESRVAMAAVPELLQQQEEDRS
KLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKM
QKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADE
VLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSD
EDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEESSCENKRADLVFIIDS
SRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGA
RPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCST
LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE
CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESY
YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH
VLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR
CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARV
GLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKA
NGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTESEPVTINIQDLLS

--------------------------------------------------------------
>85010_85010_2_SNX5-MATN2_SNX5_chr20_17928129_ENST00000377759_MATN2_chr8_98943180_ENST00000521689_length(transcript)=4311nt_BP=1373nt
TCCTCGTGGAGCGGAGCAAGGGTAGGCCCCACGTGGCGTCTTTGCCCGGCTCCAAGATGGACGGCAGCGGGGACTGGGAGGCTGCTCTGG
GGGAGCACGTGGCGCCCTGCTCGCCTGCTCCCGGGGCAGCTGGGATGGTGGCGGAGTCCGGAGGCCTCCTGCCGCCGTCGGGCAGGGAGG
CCGGCGGAGGCGGGGCCGTGGCCGCCCCCGAGAGGCGCCCAGGCGGCGGCGGCGGCGGCCCAGCTTCTTCTTTCCTCGCACAGCCAGGCG
GCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAGCAAGCTGAGATCTGTATC
TGTGGACCTGAATGTTGATCCCTCGCTTCAGATTGACATACCTGATGCGCTCAGTGAGAGAGACAAAGTCAAATTTACAGTGCACACAAA
GACCACACTGCCCACGTTTCAGAGCCCAGAGTTTTCTGTTACAAGGCAACATGAAGACTTTGTGTGGCTACATGACACTCTTATTGAAAC
AACAGACTATGCTGGGCTTATTATTCCACCTGCTCCTACGAAGCCCGACTTTGATGGTCCTCGAGAGAAGATGCAGAAACTGGGAGAAGG
TGAAGGGTCTATGACCAAAGAAGAATTTGCCAAGATGAAACAAGAACTGGAAGCTGAGTATCTCGCTGTGTTTAAGAAGACTGTGTCCTC
CCATGAAGTCTTTCTTCAGCGGCTTTCTTCTCACCCTGTTCTCAGTAAAGATCGCAACTTTCATGTTTTCCTGGAATATGATCAGGATCT
AAGTGTTAGGCGGAAAAATACTAAAGAGATGTTTGGTGGCTTCTTCAAAAGTGTGGTGAAAAGTGCTGATGAAGTCCTTTTTACTGGAGT
TAAGGAGGTAGATGACTTCTTTGAGCAAGAGAAGAACTTCCTTATTAACTATTACAATAGGATCAAAGATTCTTGTGTGAAAGCTGACAA
AATGACCAGATCTCATAAAAATGTTGCCGATGACTATATCCACACCGCAGCCTGCTTACATAGCCTGGCTTTAGAAGAGCCCACAGTCAT
CAAAAAGTACCTATTGAAGGTTGCTGAGCTATTTGAAAAACTAAGGAAAGTAGAGGGTCGAGTTTCATCAGATGAAGATTTGAAGCTAAC
AGAGCTCCTCCGATACTACATGCTCAACATTGAAGCTGCTAAGGATCTCTTATACAGACGCACCAAAGCCCTCATTGACTATGAGAACTC
AAACAAAGCTCTGGATAAGGCCCGGTTAAAGAGCAAAGACGTCAAGTTGGCTGAGGCACACCAGCAGGAGTGCTGCCAGAAATTTGAACA
ACTTTCCGAATCTGCAAAAGAAGAGAGTTCCTGTGAGAACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACAC
CCATGACTATGCAAAGGTCAAGGAGTTCATCGTGGACATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCA
ATATGGCAGCACTGTCAAGAATGAGTTCTCCCTCAAGACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCT
GTCCACGGGCACCATGACTGGGCTGGCCATCCAGTATGCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAA
TGTGCCACGGGTCATAATGATCGTGACAGATGGGAGACCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCT
AATCTTTGCCATTGGTGTGGGCCAGGTAGACTTCAACACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGC
CAATTTCAGCCAGATTGAGACGCTGACCTCCGTGTTCCAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGC
CCACTTCTGCATCAACATCCCTGGCTCATACGTCTGCAGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAATCCA
GGATCTGTGTGCCATGGAGGACCACAACTGTGAGCAGCTCTGTGTGAATGTGCCGGGCTCCTTCGTCTGCCAGTGCTACAGTGGCTACGC
CCTGGCTGAGGATGGGAAGAGGTGTGTGGCTGTGGACTACTGTGCCTCAGAAAACCACGGATGTGAACATGAGTGTGTAAATGCTGATGG
CTCCTACCTTTGCCAGTGCCATGAAGGATTTGCTCTTAACCCAGATAAAAAAACGTGCACAAAGATAGACTACTGTGCCTCATCTAATCA
CGGATGTCAGCACGAGTGTGTTAACACAGATGATTCCTATTCCTGCCACTGCCTGAAAGGCTTTACCCTGAATCCAGATAAGAAAACCTG
CAGAAGGATCAACTACTGTGCACTGAACAAACCGGGCTGTGAGCATGAGTGCGTCAACATGGAGGAGAGCTACTACTGCCGCTGCCACCG
TGGCTACACTCTGGACCCCAATGGCAAAACCTGCAGCCGAGTGGACCACTGTGCACAGCAGGACCATGGCTGTGAGCAGCTGTGTCTGAA
CACGGAGGATTCCTTCGTCTGCCAGTGCTCAGAAGGCTTCCTCATCAACGAGGACCTCAAGACCTGCTCCCGGGTGGATTACTGCCTGCT
GAGTGACCATGGTTGTGAATACTCCTGTGTCAACATGGACAGATCCTTTGCCTGTCAGTGTCCTGAGGGACACGTGCTCCGCAGCGATGG
GAAGACGTGTGCAAAATTGGACTCTTGTGCTCTGGGGGACCACGGTTGTGAACATTCGTGTGTAAGCAGTGAAGATTCGTTTGTGTGCCA
GTGCTTTGAAGGTTATATACTCCGTGAAGATGGAAAAACCTGCAGAAGGAAAGATGTCTGCCAAGCTATAGACCATGGCTGTGAACACAT
TTGTGTGAACAGTGATGACTCATACACGTGCGAGTGCTTGGAGGGATTCCGGCTCGCTGAGGATGGGAAACGCTGCCGAAGGAAGGATGT
CTGCAAATCAACCCACCATGGCTGCGAACACATTTGTGTTAATAATGGGAATTCCTACATCTGCAAATGCTCAGAGGGATTTGTTCTAGC
TGAGGACGGAAGACGGTGCAAGAAATGCACTGAAGGCCCAATTGACCTGGTCTTTGTGATCGATGGATCCAAGAGTCTTGGAGAAGAGAA
TTTTGAGGTCGTGAAGCAGTTTGTCACTGGAATTATAGATTCCTTGACAATTTCCCCCAAAGCCGCTCGAGTGGGGCTGCTCCAGTATTC
CACACAGGTCCACACAGAGTTCACTCTGAGAAACTTCAACTCAGCCAAAGACATGAAAAAAGCCGTGGCCCACATGAAATACATGGGAAA
GGGCTCTATGACTGGGCTGGCCCTGAAACACATGTTTGAGAGAAGTTTTACCCAAGGAGAAGGGGCCAGGCCCCTTTCCACAAGGGTGCC
CAGAGCAGCCATTGTGTTCACCGACGGACGGGCTCAGGATGACGTCTCCGAGTGGGCCAGTAAAGCCAAGGCCAATGGTATCACTATGTA
TGCTGTTGGGGTAGGAAAAGCCATTGAGGAGGAACTACAAGAGATTGCCTCTGAGCCCACAAACAAGCATCTCTTCTATGCCGAAGACTT
CAGCACAATGGATGAGATAAGTGAAAAACTCAAGAAAGGCATCTGTGAAGCTCTAGAAGACTCCGATGGAAGACAGGACTCTCCAGCAGG
GGAACTGCCAAAAACGGTCCAACAGCCAACAGTGCAACACAGATATCTGTTTGAAGAAGACAATCTTTTACGGTCTACACAAAAGCTTTC
CCATTCAACAAAACCTTCAGGAAGCCCTTTGGAAGAAAAACACGATCAATGCAAATGTGAAAACCTTATAATGTTCCAGAACCTTGCAAA
CGAAGAAGTAAGAAAATTAACACAGCGCTTAGAAGAAATGACACAGAGAATGGAAGCCCTGGAAAATCGCCTGAGATACAGATGAAGATT
AGAAATCGCGACACATTTGTAGTCATTGTATCACGGATTACAATGAACGCAGTGCAGAGCCCCAAAGCTCAGGCTATTGTTAAATCAATA
ATGTTGTGAAGTAAAACAATCAGTACTGAGAAACCTGGTTTGCCACAGAACAAAGACAAGAAGTATACACTAACTTGTATAAATTTATCT

>85010_85010_2_SNX5-MATN2_SNX5_chr20_17928129_ENST00000377759_MATN2_chr8_98943180_ENST00000521689_length(amino acids)=1323AA_BP=433
MGGCSGGARGALLACSRGSWDGGGVRRPPAAVGQGGRRRRGRGRPREAPRRRRRRPSFFFPRTARRPLLESRVAMAAVPELLQQQEEDRS
KLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKM
QKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADE
VLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSD
EDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEESSCENKRADLVFIIDS
SRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGA
RPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCST
LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE
CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESY
YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH
VLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR
CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARV
GLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKA
NGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLR

--------------------------------------------------------------
>85010_85010_3_SNX5-MATN2_SNX5_chr20_17928129_ENST00000377759_MATN2_chr8_98943180_ENST00000524308_length(transcript)=4477nt_BP=1373nt
TCCTCGTGGAGCGGAGCAAGGGTAGGCCCCACGTGGCGTCTTTGCCCGGCTCCAAGATGGACGGCAGCGGGGACTGGGAGGCTGCTCTGG
GGGAGCACGTGGCGCCCTGCTCGCCTGCTCCCGGGGCAGCTGGGATGGTGGCGGAGTCCGGAGGCCTCCTGCCGCCGTCGGGCAGGGAGG
CCGGCGGAGGCGGGGCCGTGGCCGCCCCCGAGAGGCGCCCAGGCGGCGGCGGCGGCGGCCCAGCTTCTTCTTTCCTCGCACAGCCAGGCG
GCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAGCAAGCTGAGATCTGTATC
TGTGGACCTGAATGTTGATCCCTCGCTTCAGATTGACATACCTGATGCGCTCAGTGAGAGAGACAAAGTCAAATTTACAGTGCACACAAA
GACCACACTGCCCACGTTTCAGAGCCCAGAGTTTTCTGTTACAAGGCAACATGAAGACTTTGTGTGGCTACATGACACTCTTATTGAAAC
AACAGACTATGCTGGGCTTATTATTCCACCTGCTCCTACGAAGCCCGACTTTGATGGTCCTCGAGAGAAGATGCAGAAACTGGGAGAAGG
TGAAGGGTCTATGACCAAAGAAGAATTTGCCAAGATGAAACAAGAACTGGAAGCTGAGTATCTCGCTGTGTTTAAGAAGACTGTGTCCTC
CCATGAAGTCTTTCTTCAGCGGCTTTCTTCTCACCCTGTTCTCAGTAAAGATCGCAACTTTCATGTTTTCCTGGAATATGATCAGGATCT
AAGTGTTAGGCGGAAAAATACTAAAGAGATGTTTGGTGGCTTCTTCAAAAGTGTGGTGAAAAGTGCTGATGAAGTCCTTTTTACTGGAGT
TAAGGAGGTAGATGACTTCTTTGAGCAAGAGAAGAACTTCCTTATTAACTATTACAATAGGATCAAAGATTCTTGTGTGAAAGCTGACAA
AATGACCAGATCTCATAAAAATGTTGCCGATGACTATATCCACACCGCAGCCTGCTTACATAGCCTGGCTTTAGAAGAGCCCACAGTCAT
CAAAAAGTACCTATTGAAGGTTGCTGAGCTATTTGAAAAACTAAGGAAAGTAGAGGGTCGAGTTTCATCAGATGAAGATTTGAAGCTAAC
AGAGCTCCTCCGATACTACATGCTCAACATTGAAGCTGCTAAGGATCTCTTATACAGACGCACCAAAGCCCTCATTGACTATGAGAACTC
AAACAAAGCTCTGGATAAGGCCCGGTTAAAGAGCAAAGACGTCAAGTTGGCTGAGGCACACCAGCAGGAGTGCTGCCAGAAATTTGAACA
ACTTTCCGAATCTGCAAAAGAAGAGAGTTCCTGTGAGAACAAGCGGGCAGACCTGGTTTTCATCATTGACAGCTCTCGCAGTGTCAACAC
CCATGACTATGCAAAGGTCAAGGAGTTCATCGTGGACATCTTGCAATTCTTGGACATTGGTCCTGATGTCACCCGAGTGGGCCTGCTCCA
ATATGGCAGCACTGTCAAGAATGAGTTCTCCCTCAAGACCTTCAAGAGGAAGTCCGAGGTGGAGCGTGCTGTCAAGAGGATGCGGCATCT
GTCCACGGGCACCATGACTGGGCTGGCCATCCAGTATGCCCTGAACATCGCATTCTCAGAAGCAGAGGGGGCCCGGCCCCTGAGGGAGAA
TGTGCCACGGGTCATAATGATCGTGACAGATGGGAGACCTCAGGACTCCGTGGCCGAGGTGGCTGCTAAGGCACGGGACACGGGCATCCT
AATCTTTGCCATTGGTGTGGGCCAGGTAGACTTCAACACCTTGAAGTCCATTGGGAGTGAGCCCCATGAGGACCATGTCTTCCTTGTGGC
CAATTTCAGCCAGATTGAGACGCTGACCTCCGTGTTCCAGAAGAAGTTGTGCACGGCCCATATGTGCAGCACCCTGGAGCATAACTGTGC
CCACTTCTGCATCAACATCCCTGGCTCATACGTCTGCAGGTGCAAACAAGGCTACATTCTCAACTCGGATCAGACGACTTGCAGAATCCA
GGATCTGTGTGCCATGGAGGACCACAACTGTGAGCAGCTCTGTGTGAATGTGCCGGGCTCCTTCGTCTGCCAGTGCTACAGTGGCTACGC
CCTGGCTGAGGATGGGAAGAGGTGTGTGGCTGTGGACTACTGTGCCTCAGAAAACCACGGATGTGAACATGAGTGTGTAAATGCTGATGG
CTCCTACCTTTGCCAGTGCCATGAAGGATTTGCTCTTAACCCAGATAAAAAAACGTGCACAAGGATCAACTACTGTGCACTGAACAAACC
GGGCTGTGAGCATGAGTGCGTCAACATGGAGGAGAGCTACTACTGCCGCTGCCACCGTGGCTACACTCTGGACCCCAATGGCAAAACCTG
CAGCCGAGTGGACCACTGTGCACAGCAGGACCATGGCTGTGAGCAGCTGTGTCTGAACACGGAGGATTCCTTCGTCTGCCAGTGCTCAGA
AGGCTTCCTCATCAACGAGGACCTCAAGACCTGCTCCCGGGTGGATTACTGCCTGCTGAGTGACCATGGTTGTGAATACTCCTGTGTCAA
CATGGACAGATCCTTTGCCTGTCAGTGTCCTGAGGGACACGTGCTCCGCAGCGATGGGAAGACGTGTGCAAAATTGGACTCTTGTGCTCT
GGGGGACCACGGTTGTGAACATTCGTGTGTAAGCAGTGAAGATTCGTTTGTGTGCCAGTGCTTTGAAGGTTATATACTCCGTGAAGATGG
AAAAACCTGCAGAAGGAAAGATGTCTGCCAAGCTATAGACCATGGCTGTGAACACATTTGTGTGAACAGTGATGACTCATACACGTGCGA
GTGCTTGGAGGGATTCCGGCTCGCTGAGGATGGGAAACGCTGCCGAAGGAAGGATGTCTGCAAATCAACCCACCATGGCTGCGAACACAT
TTGTGTTAATAATGGGAATTCCTACATCTGCAAATGCTCAGAGGGATTTGTTCTAGCTGAGGACGGAAGACGGTGCAAGAAATGCACTGA
AGGCCCAATTGACCTGGTCTTTGTGATCGATGGATCCAAGAGTCTTGGAGAAGAGAATTTTGAGGTCGTGAAGCAGTTTGTCACTGGAAT
TATAGATTCCTTGACAATTTCCCCCAAAGCCGCTCGAGTGGGGCTGCTCCAGTATTCCACACAGGTCCACACAGAGTTCACTCTGAGAAA
CTTCAACTCAGCCAAAGACATGAAAAAAGCCGTGGCCCACATGAAATACATGGGAAAGGGCTCTATGACTGGGCTGGCCCTGAAACACAT
GTTTGAGAGAAGTTTTACCCAAGGAGAAGGGGCCAGGCCCCTTTCCACAAGGGTGCCCAGAGCAGCCATTGTGTTCACCGACGGACGGGC
TCAGGATGACGTCTCCGAGTGGGCCAGTAAAGCCAAGGCCAATGGTATCACTATGTATGCTGTTGGGGTAGGAAAAGCCATTGAGGAGGA
ACTACAAGAGATTGCCTCTGAGCCCACAAACAAGCATCTCTTCTATGCCGAAGACTTCAGCACAATGGATGAGATAAGTGAAAAACTCAA
GAAAGGCATCTGTGAAGCTCTAGAAGACTCCGATGGAAGACAGGACTCTCCAGCAGGGGAACTGCCAAAAACGGTCCAACAGCCAACAGA
ATCTGAGCCAGTCACCATAAATATCCAAGACCTACTTTCCTGTTCTAATTTTGCAGTGCAACACAGATATCTGTTTGAAGAAGACAATCT
TTTACGGTCTACACAAAAGCTTTCCCATTCAACAAAACCTTCAGGAAGCCCTTTGGAAGAAAAACACGATCAATGCAAATGTGAAAACCT
TATAATGTTCCAGAACCTTGCAAACGAAGAAGTAAGAAAATTAACACAGCGCTTAGAAGAAATGACACAGAGAATGGAAGCCCTGGAAAA
TCGCCTGAGATACAGATGAAGATTAGAAATCGCGACACATTTGTAGTCATTGTATCACGGATTACAATGAACGCAGTGCAGAGCCCCAAA
GCTCAGGCTATTGTTAAATCAATAATGTTGTGAAGTAAAACAATCAGTACTGAGAAACCTGGTTTGCCACAGAACAAAGACAAGAAGTAT
ACACTAACTTGTATAAATTTATCTAGGAAAAAAATCCTTCAGAATTCTAAGATGAATTTACCAGGTGAGAATGAATAAGCTATGCAAGGT
ATTTTGTAATATACTGTGGACACAACTTGCTTCTGCCTCATCCTGCCTTAGTGTGCAATCTCATTTGACTATACGATAAAGTTTGCACAG
TCTTACTTCTGTAGAACACTGGCCATAGGAAATGCTGTTTTTTTGTACTGGACTTTACCTTGATATATGTATATGGATGTATGCATAAAA

>85010_85010_3_SNX5-MATN2_SNX5_chr20_17928129_ENST00000377759_MATN2_chr8_98943180_ENST00000524308_length(amino acids)=1301AA_BP=433
MGGCSGGARGALLACSRGSWDGGGVRRPPAAVGQGGRRRRGRGRPREAPRRRRRRPSFFFPRTARRPLLESRVAMAAVPELLQQQEEDRS
KLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKM
QKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADE
VLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSD
EDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEESSCENKRADLVFIIDS
SRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGA
RPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCST
LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE
CVNADGSYLCQCHEGFALNPDKKTCTRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSF
VCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGY
ILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRR
CKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTG
LALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDE
ISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQ

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Top

Fusion Gene PPI Analysis for SNX5-MATN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSNX5chr20:17928129chr8:98943180ENST00000377759-1113169_261359.3333333333333405.0DOCK1
HgeneSNX5chr20:17928129chr8:98943180ENST00000377768-1214169_261359.3333333333333405.0DOCK1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SNX5-MATN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SNX5-MATN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource