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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SNX5-PCSK2 (FusionGDB2 ID:85011)

Fusion Gene Summary for SNX5-PCSK2

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX5-PCSK2
Fusion gene ID: 85011
HgeneTgene
Gene symbol

SNX5

PCSK2

Gene ID

27131

5126

Gene namesorting nexin 5proprotein convertase subtilisin/kexin type 2
Synonyms-NEC 2|NEC-2|NEC2|PC2|SPC2
Cytomap

20p11.23

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-5neuroendocrine convertase 2KEX2-like endoprotease 2prohormone convertase 2
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377759, ENST00000377768, 
ENST00000483485, ENST00000481323, 
ENST00000486039, ENST00000606557, 
ENST00000606602, 		ENST00000459871, 
ENST00000262545, ENST00000377899, 
ENST00000536609, 
Fusion gene scores* DoF score8 X 8 X 5=3204 X 6 X 4=96
# samples 85
** MAII scorelog2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNX5 [Title/Abstract] AND PCSK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSNX5(17933231)-PCSK2(17338972), # samples:3
Anticipated loss of major functional domain due to fusion event.SNX5-PCSK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNX5

GO:0006907

pinocytosis

18854019

TgenePCSK2

GO:0006508

proteolysis

7626024

TgenePCSK2

GO:0016486

peptide hormone processing

28719828

TgenePCSK2

GO:0030070

insulin processing

7626024


check buttonFusion gene breakpoints across SNX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PCSK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A19L-06ASNX5chr20

17933231

-PCSK2chr20

17338972

+


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Fusion Gene ORF analysis for SNX5-PCSK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377759ENST00000459871SNX5chr20

17933231

-PCSK2chr20

17338972

+
5CDS-intronENST00000377768ENST00000459871SNX5chr20

17933231

-PCSK2chr20

17338972

+
5UTR-3CDSENST00000483485ENST00000262545SNX5chr20

17933231

-PCSK2chr20

17338972

+
5UTR-3CDSENST00000483485ENST00000377899SNX5chr20

17933231

-PCSK2chr20

17338972

+
5UTR-3CDSENST00000483485ENST00000536609SNX5chr20

17933231

-PCSK2chr20

17338972

+
5UTR-intronENST00000483485ENST00000459871SNX5chr20

17933231

-PCSK2chr20

17338972

+
Frame-shiftENST00000377768ENST00000262545SNX5chr20

17933231

-PCSK2chr20

17338972

+
Frame-shiftENST00000377768ENST00000377899SNX5chr20

17933231

-PCSK2chr20

17338972

+
Frame-shiftENST00000377768ENST00000536609SNX5chr20

17933231

-PCSK2chr20

17338972

+
In-frameENST00000377759ENST00000262545SNX5chr20

17933231

-PCSK2chr20

17338972

+
In-frameENST00000377759ENST00000377899SNX5chr20

17933231

-PCSK2chr20

17338972

+
In-frameENST00000377759ENST00000536609SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000481323ENST00000262545SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000481323ENST00000377899SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000481323ENST00000536609SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000486039ENST00000262545SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000486039ENST00000377899SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000486039ENST00000536609SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000606557ENST00000262545SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000606557ENST00000377899SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000606557ENST00000536609SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000606602ENST00000262545SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000606602ENST00000377899SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-3CDSENST00000606602ENST00000536609SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-intronENST00000481323ENST00000459871SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-intronENST00000486039ENST00000459871SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-intronENST00000606557ENST00000459871SNX5chr20

17933231

-PCSK2chr20

17338972

+
intron-intronENST00000606602ENST00000459871SNX5chr20

17933231

-PCSK2chr20

17338972

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377759SNX5chr2017933231-ENST00000377899PCSK2chr2017338972+4951808732442789
ENST00000377759SNX5chr2017933231-ENST00000262545PCSK2chr2017338972+4951808732442789
ENST00000377759SNX5chr2017933231-ENST00000536609PCSK2chr2017338972+2656808732442789

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377759ENST00000377899SNX5chr2017933231-PCSK2chr2017338972+0.0013481460.9986519
ENST00000377759ENST00000262545SNX5chr2017933231-PCSK2chr2017338972+0.0013481460.9986519
ENST00000377759ENST00000536609SNX5chr2017933231-PCSK2chr2017338972+0.007219580.9927804

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Fusion Genomic Features for SNX5-PCSK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SNX5chr2017933230-PCSK2chr2017338971+0.0020548440.99794513
SNX5chr2017933230-PCSK2chr2017338971+0.0020548440.99794513

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SNX5-PCSK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:17933231/chr20:17338972)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX5chr20:17933231chr20:17338972ENST00000377759-51325_172171405.0DomainPX
HgeneSNX5chr20:17933231chr20:17338972ENST00000377768-61425_172171405.0DomainPX
HgeneSNX5chr20:17933231chr20:17338972ENST00000377759-513113_116171405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17933231chr20:17338972ENST00000377759-51340_46171405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17933231chr20:17338972ENST00000377759-51399_105171405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17933231chr20:17338972ENST00000377768-614113_116171405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17933231chr20:17338972ENST00000377768-61440_46171405.0RegionPhosphatidylinositol bisphosphate binding
HgeneSNX5chr20:17933231chr20:17338972ENST00000377768-61499_105171405.0RegionPhosphatidylinositol bisphosphate binding
TgenePCSK2chr20:17933231chr20:17338972ENST00000262545112129_45394639.0DomainPeptidase S8
TgenePCSK2chr20:17933231chr20:17338972ENST00000262545112461_59794639.0DomainP/Homo B
TgenePCSK2chr20:17933231chr20:17338972ENST00000377899213129_45375620.0DomainPeptidase S8
TgenePCSK2chr20:17933231chr20:17338972ENST00000377899213461_59775620.0DomainP/Homo B
TgenePCSK2chr20:17933231chr20:17338972ENST00000536609011129_45359604.0DomainPeptidase S8
TgenePCSK2chr20:17933231chr20:17338972ENST00000536609011461_59759604.0DomainP/Homo B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX5chr20:17933231chr20:17338972ENST00000377759-513202_404171405.0DomainNote=BAR
HgeneSNX5chr20:17933231chr20:17338972ENST00000377768-614202_404171405.0DomainNote=BAR
HgeneSNX5chr20:17933231chr20:17338972ENST00000377759-513183_200171405.0RegionMembrane-binding amphipathic helix
HgeneSNX5chr20:17933231chr20:17338972ENST00000377768-614183_200171405.0RegionMembrane-binding amphipathic helix


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Fusion Gene Sequence for SNX5-PCSK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85011_85011_1_SNX5-PCSK2_SNX5_chr20_17933231_ENST00000377759_PCSK2_chr20_17338972_ENST00000262545_length(transcript)=4951nt_BP=808nt
TCCTCGTGGAGCGGAGCAAGGGTAGGCCCCACGTGGCGTCTTTGCCCGGCTCCAAGATGGACGGCAGCGGGGACTGGGAGGCTGCTCTGG
GGGAGCACGTGGCGCCCTGCTCGCCTGCTCCCGGGGCAGCTGGGATGGTGGCGGAGTCCGGAGGCCTCCTGCCGCCGTCGGGCAGGGAGG
CCGGCGGAGGCGGGGCCGTGGCCGCCCCCGAGAGGCGCCCAGGCGGCGGCGGCGGCGGCCCAGCTTCTTCTTTCCTCGCACAGCCAGGCG
GCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAGCAAGCTGAGATCTGTATC
TGTGGACCTGAATGTTGATCCCTCGCTTCAGATTGACATACCTGATGCGCTCAGTGAGAGAGACAAAGTCAAATTTACAGTGCACACAAA
GACCACACTGCCCACGTTTCAGAGCCCAGAGTTTTCTGTTACAAGGCAACATGAAGACTTTGTGTGGCTACATGACACTCTTATTGAAAC
AACAGACTATGCTGGGCTTATTATTCCACCTGCTCCTACGAAGCCCGACTTTGATGGTCCTCGAGAGAAGATGCAGAAACTGGGAGAAGG
TGAAGGGTCTATGACCAAAGAAGAATTTGCCAAGATGAAACAAGAACTGGAAGCTGAGTATCTCGCTGTGTTTAAGAAGACTGTGTCCTC
CCATGAAGTCTTTCTTCAGCGGCTTTCTTCTCACCCTGTTCTCAGTAAAGATCGCAACTTTCATGTTTTCCTGGAATATGATCAGGATGT
AAAGATGGCTTTGCAGCAGGAAGGATTTGACCGAAAAAAGCGAGGTTACAGAGACATCAATGAGATCGACATCAACATGAACGATCCTCT
TTTTACAAAGCAGTGGTATCTGATCAATACTGGGCAAGCTGATGGCACTCCTGGCCTTGATTTGAATGTGGCTGAAGCCTGGGAGCTGGG
ATACACAGGGAAAGGTGTTACCATTGGAATTATGGATGATGGGATTGACTATCTCCACCCGGACCTGGCCTCCAACTATAATGCCGAAGC
AAGTTACGACTTCAGCAGCAACGACCCCTATCCTTACCCTCGGTACACAGATGACTGGTTTAACAGCCACGGGACCCGATGTGCAGGAGA
AGTTTCTGCTGCCGCCAACAACAATATCTGTGGAGTTGGAGTAGCATACAACTCCAAGGTTGCAGGCATCCGGATGCTGGACCAGCCATT
CATGACAGACATCATCGAGGCCTCCTCCATCAGTCATATGCCACAGCTGATTGACATCTACAGCGCCAGCTGGGGCCCCACAGACAACGG
CAAGACAGTGGATGGGCCCCGGGAGCTCACGCTGCAGGCCATGGCCGATGGCGTGAACAAGGGCCGCGGCGGCAAAGGCAGCATCTACGT
GTGGGCCTCCGGGGACGGCGGCAGCTATGACGACTGCAACTGCGACGGCTACGCCTCCAGCATGTGGACCATCTCCATCAACTCAGCCAT
CAACGACGGCAGGACTGCCCTGTACGACGAGAGCTGCTCTTCCACCTTGGCTTCCACCTTCAGCAACGGGAGGAAAAGGAACCCCGAGGC
CGGTGTGGCAACCACAGATTTGTACGGCAACTGCACTCTGAGGCATTCTGGGACATCTGCAGCTGCCCCCGAGGCAGCTGGTGTGTTTGC
ACTGGCTCTGGAGGCTAACCTGGGTCTGACCTGGCGGGACATGCAGCATCTGACTGTGCTCACCTCCAAACGGAACCAGCTTCACGACGA
GGTCCATCAGTGGCGGCGCAATGGGGTCGGCCTGGAATTTAATCACCTCTTTGGCTACGGGGTCCTTGATGCAGGTGCCATGGTGAAAAT
GGCTAAAGACTGGAAAACCGTGCCTGAGAGATTCCACTGTGTGGGAGGCTCCGTGCAGGACCCTGAGAAAATACCATCCACTGGCAAGTT
GGTGCTGACACTCACAACCGACGCCTGTGAGGGGAAGGAAAATTTTGTCCGCTACCTGGAGCATGTCCAGGCTGTCATCACGGTCAACGC
AACCAGAAGAGGAGACCTGAACATCAACATGACTTCCCCTATGGGCACCAAGTCCATTTTGCTGAGCCGGCGTCCAAGGGATGACGACTC
CAAGGTGGGCTTTGACAAGTGGCCTTTCATGACCACTCACACGTGGGGGGAAGACGCCCGAGGCACCTGGACCCTGGAGCTGGGATTTGT
CGGCAGCGCCCCGCAGAAGGGGGTGCTGAAGGAGTGGACCCTGATGCTGCATGGCACTCAGAGTGCCCCGTACATCGACCAGGTGGTGCG
GGATTACCAGTCCAAGTTGGCCATGTCCAAGAAAGAGGAGCTGGAGGAAGAGCTGGACGAAGCCGTGGAGAGAAGCCTGAAAAGCATCCT
TAACAAGAACTAGCGCTGCACATCCGCCTTTCCCACCGCCCTCCCTCCCCAGCTCCGCCTCTGTCCTCGCTCCACGTTTCAGGCAGGCAC
CTAGCAATTCCATCACCCGTACAGGCAATTCCGTCTTCTTAATCTGAAGCTTCACTCACTGTCAATGATTATTTTCATTACAATGGAAAC
AATCTTTTTTACTCTATGCCCCAAATATAGCGTTCCCAACAACATCCATGTCCTATGTGTGACTCTAAATTCTTTATTTCTGTCATTCAA
ATGGGTGATATCCTGAAAAAAAAAAAAAAAAAAAAACTGGGACAGCTTTCCCCTCATTTTTTTTTTTGTTTCTGAGAAAAGAACGTATTT
TAAAAGCCACATAGAGTGACTCCAAGAACAATTGTCCATGGTCTCAAACAAGGGGCTGTTACATAACAAGAAAATCAAAGCTGAGGACAG
GGTGTGAGCGCCACATCTCTGAAAGCACAGGAGACACTGTGCTATAAATCCTTTGGGGAGCGATGTTTTGAATTTAGTGAGATTTACCAG
GGATGTAGATTAAGGTGATGTGATTCAAAAGATGCCATTCATAGAGAGCCCTAGTTACTGCATGGGGAAAGAGATCCAGGAAGCATGAGT
GCTGGATATTTTACTACCAATGCCAAGATAATTCACTCTACTCAGCCGGCGTGGCAAATATAAAACTTACAGAGCGTGGCTGTGCTCTCA
CCAGCTGCTGCTCTGAGTTATGTTAAAATCCGCTAGAGCAGCCCAAATTTTTCTCAGTTTGTATAGAGTTCATCCCAGCCCCAATTTTCT
GGGGCTCCTCACATAGCTACCCAAAAGAGAAAAAAAATTAAGACAAGCCTGGCAACACACCTGGTGAAGAGTAGTTTACTAGCTTTTCAA
ACAAGAATGTCCCTTTTCCTAAGTCACTTTGAGGTGTCTCAATCTGATCTGAGTGAGAGGCGACAGGAGTATTTTTTTTTTTTTACAGCT
TTACACACACAGATGTGGGCTTTGATTTCCAAGTAATATAATGGAAGAGAAATCTCATACTCCCCCACAGTTTGATGTCATTAATGTGTT
GGGAAAAAGGCCTCTGTCCCGGAAGAGTCATGGGAGGTGAAAGGGGCACGTTTGAAGATGCGAGCGCTATCTTCACATAGTTCTCCAGTT
GTATGGAGCCTCTTCTGCCAAGAGAGGGCCATGCAATTCATCCCAGAGGAACCTGAGGCCTGAAGGAGGTGAGAGAAGACCTCTGTGAGG
AAAGCACACAGTCACCTTCTCGGCAACTAAGCAGTCCCTGAGACCATTTAACATGCAACCCGAAGGTTATGGTCAATCCCAAAAGTCACC
ACTCCATTCCCAACTAGACATTACCAAAGTGACCTACCCAGAGATTGCTTCTCATCCCCAGTCCCAATGCACATCCATTCCCAAGAAATG
CTTTGTCTTCAGCCTCTCCAGGCACCATCTCCCTTCCTGTGGGAGCAGAGAGCTTAGCCTGGAGCACCTTTCCTTCAAGCCAGCAACACA
GAGCACTAGGTTCAATTCCCTGAAGGTGGCCACTTTAAGAGAGAAATCTGAAAACCCCATTTGCTTTCTTTTCTCCCATATTGGCATGGA
TTTCTGTCTTCTCTAACACCTTGTGACCTTCTCTATATCATGCTTTAAAGTGTAATAATATGATTTTTTAAAAGAAATTTATTACTTGTT
GCAAAGGTCTTTTTAAACCAGTTTAGATTTCAAGAAAAAATAAATGGAAATCATCGAAAATTCATTTCACATTAATGGTCTAAAAATAAA
CCAAAGGACATTATGTGTGCATGTGTGTATAAGTGCACACAGAAATATATATACATATGTAGACTATATACATGTGTGTATATATGTGTA
TATATACATACACTTGTATAAATGTATATACACATATACCTATAATGTGTGTATGTGTATTTATTGAAGAAACAGATACCATACTCATTT
CTAAAAGAATATTCAGAGAATATCAAGATGATTCTGGCTGAAAAAGGCCAGTGGAAATTCAGGTGAAAATGTTCATCAATTCCCATTGCA
TCACCTCTGTAATTTTTCAGCTCTCTGTATAAACATTAAATGTCTTATATAGCAGCAAAAATATAAAATAGTTGTCCATATTTTCACAGG
TGTGGTGTAATTTATAAAATTAGAAAGCAACTTATCAGCTACTTAAGAGAAATGGCAAGTTTTGATATGAGTATACAATATATAAAAATA
TATATAGTGCTATATATATAAATATTTGGTCTCTATTTCATTTTTTGCATCAGTATTAATACTAAAATATGTCTCGCTAGTGATGTTTTT
ATGATATCCCTGATCCTAACTGAAGAGACAGTTATTTATAGTCATTTATTTTAAAAAATGAAAATAAGTGAATAATAATTAGGTTAACAT
TGTTGCTCCCTGTGACAAAATTTTATAAGCAAATTTCAAAAGACATGTTGTAAATTAGGAGGCTCAACAATAAAACATTATGCTCCAGAA

>85011_85011_1_SNX5-PCSK2_SNX5_chr20_17933231_ENST00000377759_PCSK2_chr20_17338972_ENST00000262545_length(amino acids)=789AA_BP=35
MGGCSGGARGALLACSRGSWDGGGVRRPPAAVGQGGRRRRGRGRPREAPRRRRRRPSFFFPRTARRPLLESRVAMAAVPELLQQQEEDRS
KLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKM
QKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDVKMALQQEGFDRKKRGYRDINEIDI
NMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHG
TRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGG
KGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPE
AAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKI
PSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWT

--------------------------------------------------------------
>85011_85011_2_SNX5-PCSK2_SNX5_chr20_17933231_ENST00000377759_PCSK2_chr20_17338972_ENST00000377899_length(transcript)=4951nt_BP=808nt
TCCTCGTGGAGCGGAGCAAGGGTAGGCCCCACGTGGCGTCTTTGCCCGGCTCCAAGATGGACGGCAGCGGGGACTGGGAGGCTGCTCTGG
GGGAGCACGTGGCGCCCTGCTCGCCTGCTCCCGGGGCAGCTGGGATGGTGGCGGAGTCCGGAGGCCTCCTGCCGCCGTCGGGCAGGGAGG
CCGGCGGAGGCGGGGCCGTGGCCGCCCCCGAGAGGCGCCCAGGCGGCGGCGGCGGCGGCCCAGCTTCTTCTTTCCTCGCACAGCCAGGCG
GCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAGCAAGCTGAGATCTGTATC
TGTGGACCTGAATGTTGATCCCTCGCTTCAGATTGACATACCTGATGCGCTCAGTGAGAGAGACAAAGTCAAATTTACAGTGCACACAAA
GACCACACTGCCCACGTTTCAGAGCCCAGAGTTTTCTGTTACAAGGCAACATGAAGACTTTGTGTGGCTACATGACACTCTTATTGAAAC
AACAGACTATGCTGGGCTTATTATTCCACCTGCTCCTACGAAGCCCGACTTTGATGGTCCTCGAGAGAAGATGCAGAAACTGGGAGAAGG
TGAAGGGTCTATGACCAAAGAAGAATTTGCCAAGATGAAACAAGAACTGGAAGCTGAGTATCTCGCTGTGTTTAAGAAGACTGTGTCCTC
CCATGAAGTCTTTCTTCAGCGGCTTTCTTCTCACCCTGTTCTCAGTAAAGATCGCAACTTTCATGTTTTCCTGGAATATGATCAGGATGT
AAAGATGGCTTTGCAGCAGGAAGGATTTGACCGAAAAAAGCGAGGTTACAGAGACATCAATGAGATCGACATCAACATGAACGATCCTCT
TTTTACAAAGCAGTGGTATCTGATCAATACTGGGCAAGCTGATGGCACTCCTGGCCTTGATTTGAATGTGGCTGAAGCCTGGGAGCTGGG
ATACACAGGGAAAGGTGTTACCATTGGAATTATGGATGATGGGATTGACTATCTCCACCCGGACCTGGCCTCCAACTATAATGCCGAAGC
AAGTTACGACTTCAGCAGCAACGACCCCTATCCTTACCCTCGGTACACAGATGACTGGTTTAACAGCCACGGGACCCGATGTGCAGGAGA
AGTTTCTGCTGCCGCCAACAACAATATCTGTGGAGTTGGAGTAGCATACAACTCCAAGGTTGCAGGCATCCGGATGCTGGACCAGCCATT
CATGACAGACATCATCGAGGCCTCCTCCATCAGTCATATGCCACAGCTGATTGACATCTACAGCGCCAGCTGGGGCCCCACAGACAACGG
CAAGACAGTGGATGGGCCCCGGGAGCTCACGCTGCAGGCCATGGCCGATGGCGTGAACAAGGGCCGCGGCGGCAAAGGCAGCATCTACGT
GTGGGCCTCCGGGGACGGCGGCAGCTATGACGACTGCAACTGCGACGGCTACGCCTCCAGCATGTGGACCATCTCCATCAACTCAGCCAT
CAACGACGGCAGGACTGCCCTGTACGACGAGAGCTGCTCTTCCACCTTGGCTTCCACCTTCAGCAACGGGAGGAAAAGGAACCCCGAGGC
CGGTGTGGCAACCACAGATTTGTACGGCAACTGCACTCTGAGGCATTCTGGGACATCTGCAGCTGCCCCCGAGGCAGCTGGTGTGTTTGC
ACTGGCTCTGGAGGCTAACCTGGGTCTGACCTGGCGGGACATGCAGCATCTGACTGTGCTCACCTCCAAACGGAACCAGCTTCACGACGA
GGTCCATCAGTGGCGGCGCAATGGGGTCGGCCTGGAATTTAATCACCTCTTTGGCTACGGGGTCCTTGATGCAGGTGCCATGGTGAAAAT
GGCTAAAGACTGGAAAACCGTGCCTGAGAGATTCCACTGTGTGGGAGGCTCCGTGCAGGACCCTGAGAAAATACCATCCACTGGCAAGTT
GGTGCTGACACTCACAACCGACGCCTGTGAGGGGAAGGAAAATTTTGTCCGCTACCTGGAGCATGTCCAGGCTGTCATCACGGTCAACGC
AACCAGAAGAGGAGACCTGAACATCAACATGACTTCCCCTATGGGCACCAAGTCCATTTTGCTGAGCCGGCGTCCAAGGGATGACGACTC
CAAGGTGGGCTTTGACAAGTGGCCTTTCATGACCACTCACACGTGGGGGGAAGACGCCCGAGGCACCTGGACCCTGGAGCTGGGATTTGT
CGGCAGCGCCCCGCAGAAGGGGGTGCTGAAGGAGTGGACCCTGATGCTGCATGGCACTCAGAGTGCCCCGTACATCGACCAGGTGGTGCG
GGATTACCAGTCCAAGTTGGCCATGTCCAAGAAAGAGGAGCTGGAGGAAGAGCTGGACGAAGCCGTGGAGAGAAGCCTGAAAAGCATCCT
TAACAAGAACTAGCGCTGCACATCCGCCTTTCCCACCGCCCTCCCTCCCCAGCTCCGCCTCTGTCCTCGCTCCACGTTTCAGGCAGGCAC
CTAGCAATTCCATCACCCGTACAGGCAATTCCGTCTTCTTAATCTGAAGCTTCACTCACTGTCAATGATTATTTTCATTACAATGGAAAC
AATCTTTTTTACTCTATGCCCCAAATATAGCGTTCCCAACAACATCCATGTCCTATGTGTGACTCTAAATTCTTTATTTCTGTCATTCAA
ATGGGTGATATCCTGAAAAAAAAAAAAAAAAAAAAACTGGGACAGCTTTCCCCTCATTTTTTTTTTTGTTTCTGAGAAAAGAACGTATTT
TAAAAGCCACATAGAGTGACTCCAAGAACAATTGTCCATGGTCTCAAACAAGGGGCTGTTACATAACAAGAAAATCAAAGCTGAGGACAG
GGTGTGAGCGCCACATCTCTGAAAGCACAGGAGACACTGTGCTATAAATCCTTTGGGGAGCGATGTTTTGAATTTAGTGAGATTTACCAG
GGATGTAGATTAAGGTGATGTGATTCAAAAGATGCCATTCATAGAGAGCCCTAGTTACTGCATGGGGAAAGAGATCCAGGAAGCATGAGT
GCTGGATATTTTACTACCAATGCCAAGATAATTCACTCTACTCAGCCGGCGTGGCAAATATAAAACTTACAGAGCGTGGCTGTGCTCTCA
CCAGCTGCTGCTCTGAGTTATGTTAAAATCCGCTAGAGCAGCCCAAATTTTTCTCAGTTTGTATAGAGTTCATCCCAGCCCCAATTTTCT
GGGGCTCCTCACATAGCTACCCAAAAGAGAAAAAAAATTAAGACAAGCCTGGCAACACACCTGGTGAAGAGTAGTTTACTAGCTTTTCAA
ACAAGAATGTCCCTTTTCCTAAGTCACTTTGAGGTGTCTCAATCTGATCTGAGTGAGAGGCGACAGGAGTATTTTTTTTTTTTTACAGCT
TTACACACACAGATGTGGGCTTTGATTTCCAAGTAATATAATGGAAGAGAAATCTCATACTCCCCCACAGTTTGATGTCATTAATGTGTT
GGGAAAAAGGCCTCTGTCCCGGAAGAGTCATGGGAGGTGAAAGGGGCACGTTTGAAGATGCGAGCGCTATCTTCACATAGTTCTCCAGTT
GTATGGAGCCTCTTCTGCCAAGAGAGGGCCATGCAATTCATCCCAGAGGAACCTGAGGCCTGAAGGAGGTGAGAGAAGACCTCTGTGAGG
AAAGCACACAGTCACCTTCTCGGCAACTAAGCAGTCCCTGAGACCATTTAACATGCAACCCGAAGGTTATGGTCAATCCCAAAAGTCACC
ACTCCATTCCCAACTAGACATTACCAAAGTGACCTACCCAGAGATTGCTTCTCATCCCCAGTCCCAATGCACATCCATTCCCAAGAAATG
CTTTGTCTTCAGCCTCTCCAGGCACCATCTCCCTTCCTGTGGGAGCAGAGAGCTTAGCCTGGAGCACCTTTCCTTCAAGCCAGCAACACA
GAGCACTAGGTTCAATTCCCTGAAGGTGGCCACTTTAAGAGAGAAATCTGAAAACCCCATTTGCTTTCTTTTCTCCCATATTGGCATGGA
TTTCTGTCTTCTCTAACACCTTGTGACCTTCTCTATATCATGCTTTAAAGTGTAATAATATGATTTTTTAAAAGAAATTTATTACTTGTT
GCAAAGGTCTTTTTAAACCAGTTTAGATTTCAAGAAAAAATAAATGGAAATCATCGAAAATTCATTTCACATTAATGGTCTAAAAATAAA
CCAAAGGACATTATGTGTGCATGTGTGTATAAGTGCACACAGAAATATATATACATATGTAGACTATATACATGTGTGTATATATGTGTA
TATATACATACACTTGTATAAATGTATATACACATATACCTATAATGTGTGTATGTGTATTTATTGAAGAAACAGATACCATACTCATTT
CTAAAAGAATATTCAGAGAATATCAAGATGATTCTGGCTGAAAAAGGCCAGTGGAAATTCAGGTGAAAATGTTCATCAATTCCCATTGCA
TCACCTCTGTAATTTTTCAGCTCTCTGTATAAACATTAAATGTCTTATATAGCAGCAAAAATATAAAATAGTTGTCCATATTTTCACAGG
TGTGGTGTAATTTATAAAATTAGAAAGCAACTTATCAGCTACTTAAGAGAAATGGCAAGTTTTGATATGAGTATACAATATATAAAAATA
TATATAGTGCTATATATATAAATATTTGGTCTCTATTTCATTTTTTGCATCAGTATTAATACTAAAATATGTCTCGCTAGTGATGTTTTT
ATGATATCCCTGATCCTAACTGAAGAGACAGTTATTTATAGTCATTTATTTTAAAAAATGAAAATAAGTGAATAATAATTAGGTTAACAT
TGTTGCTCCCTGTGACAAAATTTTATAAGCAAATTTCAAAAGACATGTTGTAAATTAGGAGGCTCAACAATAAAACATTATGCTCCAGAA

>85011_85011_2_SNX5-PCSK2_SNX5_chr20_17933231_ENST00000377759_PCSK2_chr20_17338972_ENST00000377899_length(amino acids)=789AA_BP=35
MGGCSGGARGALLACSRGSWDGGGVRRPPAAVGQGGRRRRGRGRPREAPRRRRRRPSFFFPRTARRPLLESRVAMAAVPELLQQQEEDRS
KLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKM
QKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDVKMALQQEGFDRKKRGYRDINEIDI
NMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHG
TRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGG
KGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPE
AAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKI
PSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWT

--------------------------------------------------------------
>85011_85011_3_SNX5-PCSK2_SNX5_chr20_17933231_ENST00000377759_PCSK2_chr20_17338972_ENST00000536609_length(transcript)=2656nt_BP=808nt
TCCTCGTGGAGCGGAGCAAGGGTAGGCCCCACGTGGCGTCTTTGCCCGGCTCCAAGATGGACGGCAGCGGGGACTGGGAGGCTGCTCTGG
GGGAGCACGTGGCGCCCTGCTCGCCTGCTCCCGGGGCAGCTGGGATGGTGGCGGAGTCCGGAGGCCTCCTGCCGCCGTCGGGCAGGGAGG
CCGGCGGAGGCGGGGCCGTGGCCGCCCCCGAGAGGCGCCCAGGCGGCGGCGGCGGCGGCCCAGCTTCTTCTTTCCTCGCACAGCCAGGCG
GCCCCTGCTCGAGTCCCGCGTCGCCATGGCCGCGGTTCCCGAGTTGCTGCAGCAGCAGGAGGAGGACCGCAGCAAGCTGAGATCTGTATC
TGTGGACCTGAATGTTGATCCCTCGCTTCAGATTGACATACCTGATGCGCTCAGTGAGAGAGACAAAGTCAAATTTACAGTGCACACAAA
GACCACACTGCCCACGTTTCAGAGCCCAGAGTTTTCTGTTACAAGGCAACATGAAGACTTTGTGTGGCTACATGACACTCTTATTGAAAC
AACAGACTATGCTGGGCTTATTATTCCACCTGCTCCTACGAAGCCCGACTTTGATGGTCCTCGAGAGAAGATGCAGAAACTGGGAGAAGG
TGAAGGGTCTATGACCAAAGAAGAATTTGCCAAGATGAAACAAGAACTGGAAGCTGAGTATCTCGCTGTGTTTAAGAAGACTGTGTCCTC
CCATGAAGTCTTTCTTCAGCGGCTTTCTTCTCACCCTGTTCTCAGTAAAGATCGCAACTTTCATGTTTTCCTGGAATATGATCAGGATGT
AAAGATGGCTTTGCAGCAGGAAGGATTTGACCGAAAAAAGCGAGGTTACAGAGACATCAATGAGATCGACATCAACATGAACGATCCTCT
TTTTACAAAGCAGTGGTATCTGATCAATACTGGGCAAGCTGATGGCACTCCTGGCCTTGATTTGAATGTGGCTGAAGCCTGGGAGCTGGG
ATACACAGGGAAAGGTGTTACCATTGGAATTATGGATGATGGGATTGACTATCTCCACCCGGACCTGGCCTCCAACTATAATGCCGAAGC
AAGTTACGACTTCAGCAGCAACGACCCCTATCCTTACCCTCGGTACACAGATGACTGGTTTAACAGCCACGGGACCCGATGTGCAGGAGA
AGTTTCTGCTGCCGCCAACAACAATATCTGTGGAGTTGGAGTAGCATACAACTCCAAGGTTGCAGGCATCCGGATGCTGGACCAGCCATT
CATGACAGACATCATCGAGGCCTCCTCCATCAGTCATATGCCACAGCTGATTGACATCTACAGCGCCAGCTGGGGCCCCACAGACAACGG
CAAGACAGTGGATGGGCCCCGGGAGCTCACGCTGCAGGCCATGGCCGATGGCGTGAACAAGGGCCGCGGCGGCAAAGGCAGCATCTACGT
GTGGGCCTCCGGGGACGGCGGCAGCTATGACGACTGCAACTGCGACGGCTACGCCTCCAGCATGTGGACCATCTCCATCAACTCAGCCAT
CAACGACGGCAGGACTGCCCTGTACGACGAGAGCTGCTCTTCCACCTTGGCTTCCACCTTCAGCAACGGGAGGAAAAGGAACCCCGAGGC
CGGTGTGGCAACCACAGATTTGTACGGCAACTGCACTCTGAGGCATTCTGGGACATCTGCAGCTGCCCCCGAGGCAGCTGGTGTGTTTGC
ACTGGCTCTGGAGGCTAACCTGGGTCTGACCTGGCGGGACATGCAGCATCTGACTGTGCTCACCTCCAAACGGAACCAGCTTCACGACGA
GGTCCATCAGTGGCGGCGCAATGGGGTCGGCCTGGAATTTAATCACCTCTTTGGCTACGGGGTCCTTGATGCAGGTGCCATGGTGAAAAT
GGCTAAAGACTGGAAAACCGTGCCTGAGAGATTCCACTGTGTGGGAGGCTCCGTGCAGGACCCTGAGAAAATACCATCCACTGGCAAGTT
GGTGCTGACACTCACAACCGACGCCTGTGAGGGGAAGGAAAATTTTGTCCGCTACCTGGAGCATGTCCAGGCTGTCATCACGGTCAACGC
AACCAGAAGAGGAGACCTGAACATCAACATGACTTCCCCTATGGGCACCAAGTCCATTTTGCTGAGCCGGCGTCCAAGGGATGACGACTC
CAAGGTGGGCTTTGACAAGTGGCCTTTCATGACCACTCACACGTGGGGGGAAGACGCCCGAGGCACCTGGACCCTGGAGCTGGGATTTGT
CGGCAGCGCCCCGCAGAAGGGGGTGCTGAAGGAGTGGACCCTGATGCTGCATGGCACTCAGAGTGCCCCGTACATCGACCAGGTGGTGCG
GGATTACCAGTCCAAGTTGGCCATGTCCAAGAAAGAGGAGCTGGAGGAAGAGCTGGACGAAGCCGTGGAGAGAAGCCTGAAAAGCATCCT
TAACAAGAACTAGCGCTGCACATCCGCCTTTCCCACCGCCCTCCCTCCCCAGCTCCGCCTCTGTCCTCGCTCCACGTTTCAGGCAGGCAC
CTAGCAATTCCATCACCCGTACAGGCAATTCCGTCTTCTTAATCTGAAGCTTCACTCACTGTCAATGATTATTTTCATTACAATGGAAAC

>85011_85011_3_SNX5-PCSK2_SNX5_chr20_17933231_ENST00000377759_PCSK2_chr20_17338972_ENST00000536609_length(amino acids)=789AA_BP=35
MGGCSGGARGALLACSRGSWDGGGVRRPPAAVGQGGRRRRGRGRPREAPRRRRRRPSFFFPRTARRPLLESRVAMAAVPELLQQQEEDRS
KLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKM
QKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDVKMALQQEGFDRKKRGYRDINEIDI
NMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHG
TRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGG
KGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPE
AAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKI
PSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SNX5-PCSK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSNX5chr20:17933231chr20:17338972ENST00000377759-513169_261171.0405.0DOCK1
HgeneSNX5chr20:17933231chr20:17338972ENST00000377768-614169_261171.0405.0DOCK1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SNX5-PCSK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SNX5-PCSK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource