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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SOCS7-SRCIN1 (FusionGDB2 ID:85104)

Fusion Gene Summary for SOCS7-SRCIN1

Fusion gene summary

Fusion gene information	Fusion gene name: SOCS7-SRCIN1
	Fusion gene ID: 85104
		Hgene	Tgene
	Gene symbol	SOCS7	SRCIN1
	Gene ID	122809	80725
	Gene name	suppressor of cytokine signaling 4	SRC kinase signaling inhibitor 1
	Synonyms	SOCS7	P140\|SNIP
	Cytomap	14q22.3	17q12
	Type of gene	protein-coding	protein-coding
	Description	suppressor of cytokine signaling 4SH2 domain containing SOCS box proteinSOCS-4SOCS-7suppressor of cytokine signaling 7	SRC kinase signaling inhibitor 1P130Cas-associated proteinSNAP-25-interacting proteinSNAP25-interacting proteinp140Cap
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000331159, ENST00000577233,	ENST00000398579, ENST00000264659, ENST00000578925,
Fusion gene scores	* DoF score	11 X 7 X 7=539	12 X 10 X 6=720
	# samples	13	11
	** MAII score	log2(13/539*10)=-2.05177364972405 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/720*10)=-2.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SOCS7 [Title/Abstract] AND SRCIN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SOCS7(36533668)-SRCIN1(36705446), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SOCS7	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	15590694
Tgene	SRCIN1	GO:0061098	positive regulation of protein tyrosine kinase activity	17525734
Tgene	SRCIN1	GO:0061099	negative regulation of protein tyrosine kinase activity	17525734

Fusion gene breakpoints across SOCS7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SRCIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A07I-01A	SOCS7	chr17	36533668	-	SRCIN1	chr17	36705446	-
ChimerDB4	BRCA	TCGA-A8-A07I-01A	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-

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Fusion Gene ORF analysis for SOCS7-SRCIN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000331159	ENST00000398579	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-
5CDS-5UTR	ENST00000577233	ENST00000398579	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-
In-frame	ENST00000331159	ENST00000264659	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-
In-frame	ENST00000331159	ENST00000578925	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-
In-frame	ENST00000577233	ENST00000264659	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-
In-frame	ENST00000577233	ENST00000578925	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000331159	SOCS7	chr17	36533668	+	ENST00000264659	SRCIN1	chr17	36705446	-	5275	1404	14	1993	659
ENST00000331159	SOCS7	chr17	36533668	+	ENST00000578925	SRCIN1	chr17	36705446	-	2847	1404	14	1993	659
ENST00000577233	SOCS7	chr17	36533668	+	ENST00000264659	SRCIN1	chr17	36705446	-	5360	1489	0	2078	692
ENST00000577233	SOCS7	chr17	36533668	+	ENST00000578925	SRCIN1	chr17	36705446	-	2932	1489	0	2078	692

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000331159	ENST00000264659	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-	0.026988517	0.97301143
ENST00000331159	ENST00000578925	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-	0.055897817	0.9441021
ENST00000577233	ENST00000264659	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-	0.020826532	0.9791734
ENST00000577233	ENST00000578925	SOCS7	chr17	36533668	+	SRCIN1	chr17	36705446	-	0.0442541	0.95574594

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Fusion Genomic Features for SOCS7-SRCIN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SOCS7-SRCIN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:36533668/chr17:36705446)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

141_148

496

404.0

Compositional bias

Note=Poly-Gly

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

180_187

496

404.0

Compositional bias

Note=Poly-Gln

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

188_197

496

404.0

Compositional bias

Note=Poly-Pro

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

303_312

496

404.0

Compositional bias

Note=Poly-Pro

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

343_350

496

404.0

Compositional bias

Note=Poly-Pro

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

82_97

496

404.0

Compositional bias

Note=Poly-Pro

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

400_509

496

404.0

Domain

SH2

Hgene

SOCS7

chr17:36533668

chr17:36705446

ENST00000577233

504_554

496

404.0

Domain

SOCS box

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SRCIN1

chr17:36533668

chr17:36705446

ENST00000264659

654_674

987

1184.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SRCIN1

chr17:36533668

chr17:36705446

ENST00000264659

726_746

987

1184.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SRCIN1

chr17:36533668

chr17:36705446

ENST00000264659

471_504

987

1184.0

Compositional bias

Note=Pro-rich

Tgene

SRCIN1

chr17:36533668

chr17:36705446

ENST00000264659

956_1014

987

1184.0

Compositional bias

Note=Pro-rich

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Fusion Gene Sequence for SOCS7-SRCIN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>85104_85104_1_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000331159_SRCIN1_chr17_36705446_ENST00000264659_length(transcript)=5275nt_BP=1404nt
CCCGGCCGCCGCAGCTGATGGTGTTCCGCAACGTGGGTCGGCCGCCGGAGGAGGAGGACGTGGAGGCGGCCCCGGAGCCGGGACCCTCGG
AACTGCTGTGTCCCCGGCACCGCTGTGCCCTGGACCCCAAGGCCCTGCCGCCGGGCTTGGCGCTCGAGCGGACCTGGGGCCCGGCGGCTG
GACTAGAGGCGCAGTTGGCGGCTCTGGGGCTCGGGCAGCCGGCGGGGCCGGGGGTCAAGACAGTCGGTGGGGGTTGCTGCCCGTGTCCGT
GTCCTCCTCAGCCGCCCCCTCCGCAGCCCCAGCCGCCTGCTGCCGCCCCGCAGGCCGGGGAGGACCCCACGGAAACGAGCGACGCGCTGC
TGGTCCTGGAGGGCTTGGAATCGGAGGCCGAGAGCCTGGAGACTAACAGCTGCTCGGAAGAGGAGCTCAGCAGCCCGGGTCGCGGAGGAG
GAGGGGGCGGCCGGCTTCTGCTGCAGCCCCCAGGCCCTGAATTACCTCCGGTGCCCTTCCCGCTGCAGGACTTGGTCCCTCTGGGGCGCC
TGAGTAGAGGGGAGCAGCAGCAGCAGCAGCAGCAGCAACCTCCCCCGCCCCCGCCTCCTCCCGGGCCCCTCCGGCCACTCGCGGGTCCTT
CTCGGAAGGGCTCCTTCAAAATCCGCCTCAGTCGCCTCTTTCGCACCAAGAGCTGCAACGGTGGCTCCGGCGGTGGGGATGGGACCGGCA
AGAGGCCTTCTGGAGAGCTGGCTGCTTCAGCTGCGAGCCTGACAGACATGGGAGGCTCTGCGGGCCGGGAGCTGGACGCGGGGAGGAAAC
CCAAGTTGACAAGAACTCAAAGTGCCTTTTCTCCGGTCTCCTTCAGCCCCCTGTTCACAGGTGAAACTGTGTCGCTTGTGGATGTGGACA
TTTCTCAGCGGGGCCTGACCTCTCCACACCCTCCAACTCCCCCTCCTCCTCCGAGAAGAAGCCTCAGCCTCCTAGATGCATTTCCCCGGA
TTGCTCCCATCCGAGCAGCTGAATCCCTGCACAGCCAACCCCCACAGCACCTCCAGTGTCCCCTCTACCGGCCTGACTCGAGCAGCTTTG
CAGCCAGCCTTCGAGAGTTGGAGAAGTGTGGTTGGTATTGGGGGCCAATGAATTGGGAAGATGCAGAGATGAAGCTGAAAGGGAAACCAG
ATGGTTCTTTCCTGGTACGAGACAGTTCTGATCCTCGTTACATCCTGAGCCTCAGTTTCCGATCACAGGGTATCACCCACCACACTAGAA
TGGAGCACTACAGAGGAACCTTCAGCCTGTGGTGTCATCCCAAGTTTGAGGACCGCTGTCAATCTGTTGTAGAGTTTATTAAGAGAGCCA
TTATGCACTCCAAGAATGGAAAGTTTCTCTATTTCTTAAGATCCAGGGTTCCAGATGAGTTGACCGTGCCCCGATACCGCACAGAGAAGC
CCTCCAAGTCGCCCCCACCGCCCCCTCCCCGCCGGAGCTTCCCCTCCTCCCATGGCCTGACCACCACACGTACCGGAGAGGTGGTGGTCA
CCAGCAAGAAGGACTCGGCCTTCATCAAGAAGGCTGAGTCCGAGGAGCTGGAGGTGCAGAAGCCCCAGGTGAAGCTGCGCCGGGCTGTGT
CTGAGGTGGCCCGCCCAGCCTCCACACCACCCATCATGGCCTCGGCCATCAAGGACGAGGATGACGAGGATCGCATCATCGCAGAGCTAG
AGAGTGGCGGAGGCAGTGTACCACCCATGAAGGTGGTGACTCCGGGGGCCTCTCGGCTGAAGGCGGCCCAGGGCCAGGCGGGCAGCCCCG
ACAAAAGCAAACATGGCAAGCAGAGGGCCGAGTACATGCGGATCCAGGCCCAGCAGCAGGCCACTAAACCATCTAAAGAGATGAGCGGGT
CGAATGAGACCTCGAGCCCAGTCTCAGAAAAGCCCTCGGCTTCCAGAACCTCTATCCCTGTATTGACTTCCTTTGGGGCAAGGAATTCTT
CCATCTCCTTCTAGAAGCCCCTCACCCCGCTGCCCCGCCTGTCCCCCTCCCTCACTCCTGCCATTTCTCCCCTCTCTTCCTTCATCTCCA
CCCCACCCCACCCTACTCTCCAGACGCCCTGAGGGGTGTGCCCTGAAGAGGAGGGTGCGGCCCTCCTCAGCGACCCCTACCCATCATCTG
TTGGTGTTTTTGGTTTTGTTTTTTTTTTTTTTTTTAACAATTAACTTTTAATTATCTTTTTTTAAACAGTAAAACTAAAAACCAAACACA
CCACCTTCCTTGATCCCAGCTGGCCTCTCGCTGGCCGCACCTGTCACATCTCTCCTTCTTCTCTTTCACCACTCTTTCCCCCAGTCCATC
CTGAAGCTCCTGCACCCCCTTCCCGCCTTCCCCTCACTTCCCAAGAATACTCCAAACAAACTCTGAACCACGGAGACTTGGAGCAGTGGG
AGACCCCTCTCCCGTTTCTCGATACCTTCCTGGAGGAACGCGGGGACATCGGACCAACCCATACATCAAGCCAGAGAGCGGGGCTTAGGG
AGACTGGCCTTGGAGATGCCCCACTCCCTGTCTAAGCTCCGACAAGACTGTGACTTCCTCTGTGGCTGCTCTGCCTCCTCCCACTCACAC
CCAAGTGGGCCTGGAGTAGAGACGGACAGGCTGGAGACGAGGCCGGAGTTTGAGAGGCCTCAGGGTGGGTGTGAGGCCATGGAGTCTGTA
TCCCTGGGGAGGCGCTGGCCTCCTGGGCCTTGCCGTCCAGTGGGGAGTGGAGGGCAGAGGCCCTTTGGTCTGCTGGCTGTGGAGGGTGGG
TTGCACGGACAGCCGGATATCGGGGACACTGCCTTGGGAGAGGGCGGCCCGGACGGGTATTTGGTACTTTTAGTTTCCTGATTTAGCACT
TTAAATGGCATTAACTTATTGAATGGGGATGGGGTGGGCAAGAGTGAGGGGCCTAGAAAACCAGGTTTTGTGGCTTGCAGTTGGGGGAAG
GGTCTGGTTTGAGGGAAATGGGAGGGTCGAGAGGGGCTTGACGGGGAGCACTGAAGACACCTGGGACCCGCAGGTGGGGTGACTTGAACT
TCAGTCATCCTCTTGGCAATTTGAGGGTTTTCCCAGGAAAGGATGAGACGTAGTTTTTCAATGGGGCTCTGGTGACCCTGGTGAGATGTC
TGAAGGTCCCTGAGGCCTGACCATCCAGCCAGCGCCCCTGGCCTGTGGACGCCCTGCCTGCCCTGCAGAGGCGGTTGGCAGTGCCGCCTG
GCTTTTGGCCGGGTCCTGGGGAGGCAGAGAGAGGCCAATTTTGGTTCTCACTCCTGGCCCCCCAGAGGGCACAGTGAGGAGCCGGTAGGG
AGAGGATAGGAGAAGAGGAGGAGGAGGAGCGGGGTCCCCGGCCGCAGGATTCCCACTTGGAGCACAAAGTGAAGTAAGCACAGGGGAGGG
GGACTAGAATCAGTCCCCCATAGCAAGCACAGAAAGGAGGAGCTGCGCAGAAGGCAGAGCCCCCCAGACCCTGGGGCCTGGCTGGGGAAG
GTCCGCACCTGGGGAGAGCTGGGAGCTGTTGAAGGTTTGGGGGGAGGGGAAACGGGTTGTGTTTCTTCATTTCTTTTTTTGTTTTTGCCT
TTGTTGGTTCATCCTTGTTTTCTAGCTTTGGATCATTTTTGTACCAAGGCGAGCAAGCCTTTTTGAAAAATAACAAAAGAGGAAAAAAAA
AATCCCTCCTGGAAAAAAAAAAAAACCCTGGAAAATAGAAAAAAAAAAAAGGACCTCATAAATGATGCAATTACTTTTAATTGCAGGCAA
CTCTTTACATTTAAGTGAAGTGTCTTAACATTTTATATTGTTTTAAAAATATATTTACATATTATATATATAATATACGTAATATAAATA
TATATAAATATTTAAAAAAGAAAAAAAAAAGAAAACCACGGCACTCTCCCTGGCCACTGTTTTGGCGGGGGAGGGGGGCTGGGGGGCGGG
CACGTCGGCCTGGCTTCTGTGGTCCCAGTGAAATGGTCTGGTTTGATTTGGCTGTACAGAGACCCCCTGACTTGGGAGGGGAGGGGGGAG
TGGTGCCCCCTCCTCCCTCCACTCCATTACTCTCTGCTTGCTACTTCGCTTGCCCCCAGCTCCCACCCTCAGCCCTGTGACTGGAATGTG
TGCCCCACCGTCATTGTCCTGAGTTGAATGTCCCTTTGTGGGGGAGGTGGGGGGGGCAGTGTCCATCCACGAAGGGGCAGAAGGAGGGAG
CCACGTGCCCCGCCCCACCCGCTCGGGTGAAGCCCAGTGGGATTTGCATCTTTCTTTCTCTTTGGTTCCTGCACATTTATGGGCTGGGAG
GCATCCGTGTGGAATTGCGTGCAGCCTGTGTGTGTGCTGGCACAAGCCCATGCACTGTGTGTGCAGACGCATGGGGCCTGCACCCACAGG
CATGGCCGAGCACATGTGTGGGGGAAGGCGTGGGCACATAGGTGCATGTAACCTGTTTGGGCATTGGCACGTGCCTACCTGCATGTTAGC
GTGAGAGGAGCTTTGTGTGTGAGAACATGTGTAATGTGTGTGCAGACATGCCGAGAGCCAGAGACTTGTGTGTGGGCCACGTACATGTGG
ATAGAGACGCATACATGGAGGTGCATGTAATCTGTGTCTCCGAGTGTGTGTGTGCAGGTATGTGTGCTGGTGCAGACCCAAGTGTGTGGG
TGTGCCTCTGTGTGCGTGTGTTCCATCATCCCTGCACCACTGGCTCCAGATCCCTTCCTGAGCCCCCGTCCCCGCTGGCCCTCTCACAGC
CTGCAGCACATCAGTGCCCCCAGCTGCATGCGCCTCGCTGCTCTGTCCATCAGTGTGTGCTTGACCAAGAGAAAACTAAGACGTCTCGGG
GGACCCCTGTACCTGGTCCTCTCAGCCCCCGCCCACTGTGCTGTGTTACTCGCATGGGGGATTTCCTGCCCCTTCCACAATATGCTGTTT
CCCCAGGAGCCTCAGGCCTGAGGCTCTGAGTGGGGTCCCCAGGGGGCCCCCCGGGGTGAGCCCCGGCTCCACACCCTGCCCCATCCACCC
TGTAGGGCCCATGTTGGTGTAGCAGTGATGGCTTCTGTGGATATTCTGTGACCTCTGTCGGTGTAACTTGACAATTTCTAAATGGAAAAG
GGTTGCTGTGTTTTCTCTGTCTCTCTTTTTTAATGTCCTTTTTTCTTCTCCCCCGCTCCCTGCTCTCTTTCCTTTTCAGTTTTTCTAGCC

>85104_85104_1_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000331159_SRCIN1_chr17_36705446_ENST00000264659_length(amino acids)=659AA_BP=453
MMVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQP
PPPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGE
QQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTR
TQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLR
ELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSK
NGKFLYFLRSRVPDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVAR
PASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETS

--------------------------------------------------------------
>85104_85104_2_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000331159_SRCIN1_chr17_36705446_ENST00000578925_length(transcript)=2847nt_BP=1404nt
CCCGGCCGCCGCAGCTGATGGTGTTCCGCAACGTGGGTCGGCCGCCGGAGGAGGAGGACGTGGAGGCGGCCCCGGAGCCGGGACCCTCGG
AACTGCTGTGTCCCCGGCACCGCTGTGCCCTGGACCCCAAGGCCCTGCCGCCGGGCTTGGCGCTCGAGCGGACCTGGGGCCCGGCGGCTG
GACTAGAGGCGCAGTTGGCGGCTCTGGGGCTCGGGCAGCCGGCGGGGCCGGGGGTCAAGACAGTCGGTGGGGGTTGCTGCCCGTGTCCGT
GTCCTCCTCAGCCGCCCCCTCCGCAGCCCCAGCCGCCTGCTGCCGCCCCGCAGGCCGGGGAGGACCCCACGGAAACGAGCGACGCGCTGC
TGGTCCTGGAGGGCTTGGAATCGGAGGCCGAGAGCCTGGAGACTAACAGCTGCTCGGAAGAGGAGCTCAGCAGCCCGGGTCGCGGAGGAG
GAGGGGGCGGCCGGCTTCTGCTGCAGCCCCCAGGCCCTGAATTACCTCCGGTGCCCTTCCCGCTGCAGGACTTGGTCCCTCTGGGGCGCC
TGAGTAGAGGGGAGCAGCAGCAGCAGCAGCAGCAGCAACCTCCCCCGCCCCCGCCTCCTCCCGGGCCCCTCCGGCCACTCGCGGGTCCTT
CTCGGAAGGGCTCCTTCAAAATCCGCCTCAGTCGCCTCTTTCGCACCAAGAGCTGCAACGGTGGCTCCGGCGGTGGGGATGGGACCGGCA
AGAGGCCTTCTGGAGAGCTGGCTGCTTCAGCTGCGAGCCTGACAGACATGGGAGGCTCTGCGGGCCGGGAGCTGGACGCGGGGAGGAAAC
CCAAGTTGACAAGAACTCAAAGTGCCTTTTCTCCGGTCTCCTTCAGCCCCCTGTTCACAGGTGAAACTGTGTCGCTTGTGGATGTGGACA
TTTCTCAGCGGGGCCTGACCTCTCCACACCCTCCAACTCCCCCTCCTCCTCCGAGAAGAAGCCTCAGCCTCCTAGATGCATTTCCCCGGA
TTGCTCCCATCCGAGCAGCTGAATCCCTGCACAGCCAACCCCCACAGCACCTCCAGTGTCCCCTCTACCGGCCTGACTCGAGCAGCTTTG
CAGCCAGCCTTCGAGAGTTGGAGAAGTGTGGTTGGTATTGGGGGCCAATGAATTGGGAAGATGCAGAGATGAAGCTGAAAGGGAAACCAG
ATGGTTCTTTCCTGGTACGAGACAGTTCTGATCCTCGTTACATCCTGAGCCTCAGTTTCCGATCACAGGGTATCACCCACCACACTAGAA
TGGAGCACTACAGAGGAACCTTCAGCCTGTGGTGTCATCCCAAGTTTGAGGACCGCTGTCAATCTGTTGTAGAGTTTATTAAGAGAGCCA
TTATGCACTCCAAGAATGGAAAGTTTCTCTATTTCTTAAGATCCAGGGTTCCAGATGAGTTGACCGTGCCCCGATACCGCACAGAGAAGC
CCTCCAAGTCGCCCCCACCGCCCCCTCCCCGCCGGAGCTTCCCCTCCTCCCATGGCCTGACCACCACACGTACCGGAGAGGTGGTGGTCA
CCAGCAAGAAGGACTCGGCCTTCATCAAGAAGGCTGAGTCCGAGGAGCTGGAGGTGCAGAAGCCCCAGGTGAAGCTGCGCCGGGCTGTGT
CTGAGGTGGCCCGCCCAGCCTCCACACCACCCATCATGGCCTCGGCCATCAAGGACGAGGATGACGAGGATCGCATCATCGCAGAGCTAG
AGAGTGGCGGAGGCAGTGTACCACCCATGAAGGTGGTGACTCCGGGGGCCTCTCGGCTGAAGGCGGCCCAGGGCCAGGCGGGCAGCCCCG
ACAAAAGCAAACATGGCAAGCAGAGGGCCGAGTACATGCGGATCCAGGCCCAGCAGCAGGCCACTAAACCATCTAAAGAGATGAGCGGGT
CGAATGAGACCTCGAGCCCAGTCTCAGAAAAGCCCTCGGCTTCCAGAACCTCTATCCCTGTATTGACTTCCTTTGGGGCAAGGAATTCTT
CCATCTCCTTCTAGAAGCCCCTCACCCCGCTGCCCCGCCTGTCCCCCTCCCTCACTCCTGCCATTTCTCCCCTCTCTTCCTTCATCTCCA
CCCCACCCCACCCTACTCTCCAGACGCCCTGAGGGGTGTGCCCTGAAGAGGAGGGTGCGGCCCTCCTCAGCGACCCCTACCCATCATCTG
TTGGTGTTTTTGGTTTTGTTTTTTTTTTTTTTTTTAACAATTAACTTTTAATTATCTTTTTTTAAACAGTAAAACTAAAAACCAAACACA
CCACCTTCCTTGATCCCAGCTGGCCTCTCGCTGGCCGCACCTGTCACATCTCTCCTTCTTCTCTTTCACCACTCTTTCCCCCAGTCCATC
CTGAAGCTCCTGCACCCCCTTCCCGCCTTCCCCTCACTTCCCAAGAATACTCCAAACAAACTCTGAACCACGGAGACTTGGAGCAGTGGG
AGACCCCTCTCCCGTTTCTCGATACCTTCCTGGAGGAACGCGGGGACATCGGACCAACCCATACATCAAGCCAGAGAGCGGGGCTTAGGG
AGACTGGCCTTGGAGATGCCCCACTCCCTGTCTAAGCTCCGACAAGACTGTGACTTCCTCTGTGGCTGCTCTGCCTCCTCCCACTCACAC
CCAAGTGGGCCTGGAGTAGAGACGGACAGGCTGGAGACGAGGCCGGAGTTTGAGAGGCCTCAGGGTGGGTGTGAGGCCATGGAGTCTGTA
TCCCTGGGGAGGCGCTGGCCTCCTGGGCCTTGCCGTCCAGTGGGGAGTGGAGGGCAGAGGCCCTTTGGTCTGCTGGCTGTGGAGGGTGGG

>85104_85104_2_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000331159_SRCIN1_chr17_36705446_ENST00000578925_length(amino acids)=659AA_BP=453
MMVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQP
PPPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGE
QQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTR
TQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLR
ELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSK
NGKFLYFLRSRVPDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVAR
PASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETS

--------------------------------------------------------------
>85104_85104_3_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000577233_SRCIN1_chr17_36705446_ENST00000264659_length(transcript)=5360nt_BP=1489nt
ATGGTGTTCCGCAACGTGGGTCGGCCGCCGGAGGAGGAGGACGTGGAGGCGGCCCCGGAGCCGGGACCCTCGGAACTGCTGTGTCCCCGG
CACCGCTGTGCCCTGGACCCCAAGGCCCTGCCGCCGGGCTTGGCGCTCGAGCGGACCTGGGGCCCGGCGGCTGGACTAGAGGCGCAGTTG
GCGGCTCTGGGGCTCGGGCAGCCGGCGGGGCCGGGGGTCAAGACAGTCGGTGGGGGTTGCTGCCCGTGTCCGTGTCCTCCTCAGCCGCCC
CCTCCGCAGCCCCAGCCGCCTGCTGCCGCCCCGCAGGCCGGGGAGGACCCCACGGAAACGAGCGACGCGCTGCTGGTCCTGGAGGGCTTG
GAATCGGAGGCCGAGAGCCTGGAGACTAACAGCTGCTCGGAAGAGGAGCTCAGCAGCCCGGGTCGCGGAGGAGGAGGGGGCGGCCGGCTT
CTGCTGCAGCCCCCAGGCCCTGAATTACCTCCGGTGCCCTTCCCGCTGCAGGACTTGGTCCCTCTGGGGCGCCTGAGTAGAGGGGAGCAG
CAGCAGCAGCAGCAGCAGCAACCTCCCCCGCCCCCGCCTCCTCCCGGGCCCCTCCGGCCACTCGCGGGTCCTTCTCGGAAGGGCTCCTTC
AAAATCCGCCTCAGTCGCCTCTTTCGCACCAAGAGCTGCAACGGTGGCTCCGGCGGTGGGGATGGGACCGGCAAGAGGCCTTCTGGAGAG
CTGGCTGCTTCAGCTGCGAGCCTGACAGACATGGGAGGCTCTGCGGGCCGGGAGCTGGACGCGGGGAGGAAACCCAAGTTGACAAGAACT
CAAAGTGCCTTTTCTCCGGTCTCCTTCAGCCCCCTGTTCACAGGTGAAACTGTGTCGCTTGTGGATGTGGACATTTCTCAGCGGGGCCTG
ACCTCTCCACACCCTCCAACTCCCCCTCCTCCTCCGAGAAGAAGCCTCAGCCTCCTAGATGATATCAGTGGGACGCTGCCTACATCTGTC
CTTGTGGCTCCGATGGGGTCTTCCTTGCAGTCTTTCCCCCTACCTCCGCCTCCTCCACCCCATGCCCCAGATGCATTTCCCCGGATTGCT
CCCATCCGAGCAGCTGAATCCCTGCACAGCCAACCCCCACAGCACCTCCAGTGTCCCCTCTACCGGCCTGACTCGAGCAGCTTTGCAGCC
AGCCTTCGAGAGTTGGAGAAGTGTGGTTGGTATTGGGGGCCAATGAATTGGGAAGATGCAGAGATGAAGCTGAAAGGGAAACCAGATGGT
TCTTTCCTGGTACGAGACAGTTCTGATCCTCGTTACATCCTGAGCCTCAGTTTCCGATCACAGGGTATCACCCACCACACTAGAATGGAG
CACTACAGAGGAACCTTCAGCCTGTGGTGTCATCCCAAGTTTGAGGACCGCTGTCAATCTGTTGTAGAGTTTATTAAGAGAGCCATTATG
CACTCCAAGAATGGAAAGTTTCTCTATTTCTTAAGATCCAGGGTTCCAGATGAGTTGACCGTGCCCCGATACCGCACAGAGAAGCCCTCC
AAGTCGCCCCCACCGCCCCCTCCCCGCCGGAGCTTCCCCTCCTCCCATGGCCTGACCACCACACGTACCGGAGAGGTGGTGGTCACCAGC
AAGAAGGACTCGGCCTTCATCAAGAAGGCTGAGTCCGAGGAGCTGGAGGTGCAGAAGCCCCAGGTGAAGCTGCGCCGGGCTGTGTCTGAG
GTGGCCCGCCCAGCCTCCACACCACCCATCATGGCCTCGGCCATCAAGGACGAGGATGACGAGGATCGCATCATCGCAGAGCTAGAGAGT
GGCGGAGGCAGTGTACCACCCATGAAGGTGGTGACTCCGGGGGCCTCTCGGCTGAAGGCGGCCCAGGGCCAGGCGGGCAGCCCCGACAAA
AGCAAACATGGCAAGCAGAGGGCCGAGTACATGCGGATCCAGGCCCAGCAGCAGGCCACTAAACCATCTAAAGAGATGAGCGGGTCGAAT
GAGACCTCGAGCCCAGTCTCAGAAAAGCCCTCGGCTTCCAGAACCTCTATCCCTGTATTGACTTCCTTTGGGGCAAGGAATTCTTCCATC
TCCTTCTAGAAGCCCCTCACCCCGCTGCCCCGCCTGTCCCCCTCCCTCACTCCTGCCATTTCTCCCCTCTCTTCCTTCATCTCCACCCCA
CCCCACCCTACTCTCCAGACGCCCTGAGGGGTGTGCCCTGAAGAGGAGGGTGCGGCCCTCCTCAGCGACCCCTACCCATCATCTGTTGGT
GTTTTTGGTTTTGTTTTTTTTTTTTTTTTTAACAATTAACTTTTAATTATCTTTTTTTAAACAGTAAAACTAAAAACCAAACACACCACC
TTCCTTGATCCCAGCTGGCCTCTCGCTGGCCGCACCTGTCACATCTCTCCTTCTTCTCTTTCACCACTCTTTCCCCCAGTCCATCCTGAA
GCTCCTGCACCCCCTTCCCGCCTTCCCCTCACTTCCCAAGAATACTCCAAACAAACTCTGAACCACGGAGACTTGGAGCAGTGGGAGACC
CCTCTCCCGTTTCTCGATACCTTCCTGGAGGAACGCGGGGACATCGGACCAACCCATACATCAAGCCAGAGAGCGGGGCTTAGGGAGACT
GGCCTTGGAGATGCCCCACTCCCTGTCTAAGCTCCGACAAGACTGTGACTTCCTCTGTGGCTGCTCTGCCTCCTCCCACTCACACCCAAG
TGGGCCTGGAGTAGAGACGGACAGGCTGGAGACGAGGCCGGAGTTTGAGAGGCCTCAGGGTGGGTGTGAGGCCATGGAGTCTGTATCCCT
GGGGAGGCGCTGGCCTCCTGGGCCTTGCCGTCCAGTGGGGAGTGGAGGGCAGAGGCCCTTTGGTCTGCTGGCTGTGGAGGGTGGGTTGCA
CGGACAGCCGGATATCGGGGACACTGCCTTGGGAGAGGGCGGCCCGGACGGGTATTTGGTACTTTTAGTTTCCTGATTTAGCACTTTAAA
TGGCATTAACTTATTGAATGGGGATGGGGTGGGCAAGAGTGAGGGGCCTAGAAAACCAGGTTTTGTGGCTTGCAGTTGGGGGAAGGGTCT
GGTTTGAGGGAAATGGGAGGGTCGAGAGGGGCTTGACGGGGAGCACTGAAGACACCTGGGACCCGCAGGTGGGGTGACTTGAACTTCAGT
CATCCTCTTGGCAATTTGAGGGTTTTCCCAGGAAAGGATGAGACGTAGTTTTTCAATGGGGCTCTGGTGACCCTGGTGAGATGTCTGAAG
GTCCCTGAGGCCTGACCATCCAGCCAGCGCCCCTGGCCTGTGGACGCCCTGCCTGCCCTGCAGAGGCGGTTGGCAGTGCCGCCTGGCTTT
TGGCCGGGTCCTGGGGAGGCAGAGAGAGGCCAATTTTGGTTCTCACTCCTGGCCCCCCAGAGGGCACAGTGAGGAGCCGGTAGGGAGAGG
ATAGGAGAAGAGGAGGAGGAGGAGCGGGGTCCCCGGCCGCAGGATTCCCACTTGGAGCACAAAGTGAAGTAAGCACAGGGGAGGGGGACT
AGAATCAGTCCCCCATAGCAAGCACAGAAAGGAGGAGCTGCGCAGAAGGCAGAGCCCCCCAGACCCTGGGGCCTGGCTGGGGAAGGTCCG
CACCTGGGGAGAGCTGGGAGCTGTTGAAGGTTTGGGGGGAGGGGAAACGGGTTGTGTTTCTTCATTTCTTTTTTTGTTTTTGCCTTTGTT
GGTTCATCCTTGTTTTCTAGCTTTGGATCATTTTTGTACCAAGGCGAGCAAGCCTTTTTGAAAAATAACAAAAGAGGAAAAAAAAAATCC
CTCCTGGAAAAAAAAAAAAACCCTGGAAAATAGAAAAAAAAAAAAGGACCTCATAAATGATGCAATTACTTTTAATTGCAGGCAACTCTT
TACATTTAAGTGAAGTGTCTTAACATTTTATATTGTTTTAAAAATATATTTACATATTATATATATAATATACGTAATATAAATATATAT
AAATATTTAAAAAAGAAAAAAAAAAGAAAACCACGGCACTCTCCCTGGCCACTGTTTTGGCGGGGGAGGGGGGCTGGGGGGCGGGCACGT
CGGCCTGGCTTCTGTGGTCCCAGTGAAATGGTCTGGTTTGATTTGGCTGTACAGAGACCCCCTGACTTGGGAGGGGAGGGGGGAGTGGTG
CCCCCTCCTCCCTCCACTCCATTACTCTCTGCTTGCTACTTCGCTTGCCCCCAGCTCCCACCCTCAGCCCTGTGACTGGAATGTGTGCCC
CACCGTCATTGTCCTGAGTTGAATGTCCCTTTGTGGGGGAGGTGGGGGGGGCAGTGTCCATCCACGAAGGGGCAGAAGGAGGGAGCCACG
TGCCCCGCCCCACCCGCTCGGGTGAAGCCCAGTGGGATTTGCATCTTTCTTTCTCTTTGGTTCCTGCACATTTATGGGCTGGGAGGCATC
CGTGTGGAATTGCGTGCAGCCTGTGTGTGTGCTGGCACAAGCCCATGCACTGTGTGTGCAGACGCATGGGGCCTGCACCCACAGGCATGG
CCGAGCACATGTGTGGGGGAAGGCGTGGGCACATAGGTGCATGTAACCTGTTTGGGCATTGGCACGTGCCTACCTGCATGTTAGCGTGAG
AGGAGCTTTGTGTGTGAGAACATGTGTAATGTGTGTGCAGACATGCCGAGAGCCAGAGACTTGTGTGTGGGCCACGTACATGTGGATAGA
GACGCATACATGGAGGTGCATGTAATCTGTGTCTCCGAGTGTGTGTGTGCAGGTATGTGTGCTGGTGCAGACCCAAGTGTGTGGGTGTGC
CTCTGTGTGCGTGTGTTCCATCATCCCTGCACCACTGGCTCCAGATCCCTTCCTGAGCCCCCGTCCCCGCTGGCCCTCTCACAGCCTGCA
GCACATCAGTGCCCCCAGCTGCATGCGCCTCGCTGCTCTGTCCATCAGTGTGTGCTTGACCAAGAGAAAACTAAGACGTCTCGGGGGACC
CCTGTACCTGGTCCTCTCAGCCCCCGCCCACTGTGCTGTGTTACTCGCATGGGGGATTTCCTGCCCCTTCCACAATATGCTGTTTCCCCA
GGAGCCTCAGGCCTGAGGCTCTGAGTGGGGTCCCCAGGGGGCCCCCCGGGGTGAGCCCCGGCTCCACACCCTGCCCCATCCACCCTGTAG
GGCCCATGTTGGTGTAGCAGTGATGGCTTCTGTGGATATTCTGTGACCTCTGTCGGTGTAACTTGACAATTTCTAAATGGAAAAGGGTTG
CTGTGTTTTCTCTGTCTCTCTTTTTTAATGTCCTTTTTTCTTCTCCCCCGCTCCCTGCTCTCTTTCCTTTTCAGTTTTTCTAGCCAAGTG

>85104_85104_3_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000577233_SRCIN1_chr17_36705446_ENST00000264659_length(amino acids)=692AA_BP=486
MVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQPP
PPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQ
QQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTRT
QSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIA
PIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRME
HYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTS
KKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDK

--------------------------------------------------------------
>85104_85104_4_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000577233_SRCIN1_chr17_36705446_ENST00000578925_length(transcript)=2932nt_BP=1489nt
ATGGTGTTCCGCAACGTGGGTCGGCCGCCGGAGGAGGAGGACGTGGAGGCGGCCCCGGAGCCGGGACCCTCGGAACTGCTGTGTCCCCGG
CACCGCTGTGCCCTGGACCCCAAGGCCCTGCCGCCGGGCTTGGCGCTCGAGCGGACCTGGGGCCCGGCGGCTGGACTAGAGGCGCAGTTG
GCGGCTCTGGGGCTCGGGCAGCCGGCGGGGCCGGGGGTCAAGACAGTCGGTGGGGGTTGCTGCCCGTGTCCGTGTCCTCCTCAGCCGCCC
CCTCCGCAGCCCCAGCCGCCTGCTGCCGCCCCGCAGGCCGGGGAGGACCCCACGGAAACGAGCGACGCGCTGCTGGTCCTGGAGGGCTTG
GAATCGGAGGCCGAGAGCCTGGAGACTAACAGCTGCTCGGAAGAGGAGCTCAGCAGCCCGGGTCGCGGAGGAGGAGGGGGCGGCCGGCTT
CTGCTGCAGCCCCCAGGCCCTGAATTACCTCCGGTGCCCTTCCCGCTGCAGGACTTGGTCCCTCTGGGGCGCCTGAGTAGAGGGGAGCAG
CAGCAGCAGCAGCAGCAGCAACCTCCCCCGCCCCCGCCTCCTCCCGGGCCCCTCCGGCCACTCGCGGGTCCTTCTCGGAAGGGCTCCTTC
AAAATCCGCCTCAGTCGCCTCTTTCGCACCAAGAGCTGCAACGGTGGCTCCGGCGGTGGGGATGGGACCGGCAAGAGGCCTTCTGGAGAG
CTGGCTGCTTCAGCTGCGAGCCTGACAGACATGGGAGGCTCTGCGGGCCGGGAGCTGGACGCGGGGAGGAAACCCAAGTTGACAAGAACT
CAAAGTGCCTTTTCTCCGGTCTCCTTCAGCCCCCTGTTCACAGGTGAAACTGTGTCGCTTGTGGATGTGGACATTTCTCAGCGGGGCCTG
ACCTCTCCACACCCTCCAACTCCCCCTCCTCCTCCGAGAAGAAGCCTCAGCCTCCTAGATGATATCAGTGGGACGCTGCCTACATCTGTC
CTTGTGGCTCCGATGGGGTCTTCCTTGCAGTCTTTCCCCCTACCTCCGCCTCCTCCACCCCATGCCCCAGATGCATTTCCCCGGATTGCT
CCCATCCGAGCAGCTGAATCCCTGCACAGCCAACCCCCACAGCACCTCCAGTGTCCCCTCTACCGGCCTGACTCGAGCAGCTTTGCAGCC
AGCCTTCGAGAGTTGGAGAAGTGTGGTTGGTATTGGGGGCCAATGAATTGGGAAGATGCAGAGATGAAGCTGAAAGGGAAACCAGATGGT
TCTTTCCTGGTACGAGACAGTTCTGATCCTCGTTACATCCTGAGCCTCAGTTTCCGATCACAGGGTATCACCCACCACACTAGAATGGAG
CACTACAGAGGAACCTTCAGCCTGTGGTGTCATCCCAAGTTTGAGGACCGCTGTCAATCTGTTGTAGAGTTTATTAAGAGAGCCATTATG
CACTCCAAGAATGGAAAGTTTCTCTATTTCTTAAGATCCAGGGTTCCAGATGAGTTGACCGTGCCCCGATACCGCACAGAGAAGCCCTCC
AAGTCGCCCCCACCGCCCCCTCCCCGCCGGAGCTTCCCCTCCTCCCATGGCCTGACCACCACACGTACCGGAGAGGTGGTGGTCACCAGC
AAGAAGGACTCGGCCTTCATCAAGAAGGCTGAGTCCGAGGAGCTGGAGGTGCAGAAGCCCCAGGTGAAGCTGCGCCGGGCTGTGTCTGAG
GTGGCCCGCCCAGCCTCCACACCACCCATCATGGCCTCGGCCATCAAGGACGAGGATGACGAGGATCGCATCATCGCAGAGCTAGAGAGT
GGCGGAGGCAGTGTACCACCCATGAAGGTGGTGACTCCGGGGGCCTCTCGGCTGAAGGCGGCCCAGGGCCAGGCGGGCAGCCCCGACAAA
AGCAAACATGGCAAGCAGAGGGCCGAGTACATGCGGATCCAGGCCCAGCAGCAGGCCACTAAACCATCTAAAGAGATGAGCGGGTCGAAT
GAGACCTCGAGCCCAGTCTCAGAAAAGCCCTCGGCTTCCAGAACCTCTATCCCTGTATTGACTTCCTTTGGGGCAAGGAATTCTTCCATC
TCCTTCTAGAAGCCCCTCACCCCGCTGCCCCGCCTGTCCCCCTCCCTCACTCCTGCCATTTCTCCCCTCTCTTCCTTCATCTCCACCCCA
CCCCACCCTACTCTCCAGACGCCCTGAGGGGTGTGCCCTGAAGAGGAGGGTGCGGCCCTCCTCAGCGACCCCTACCCATCATCTGTTGGT
GTTTTTGGTTTTGTTTTTTTTTTTTTTTTTAACAATTAACTTTTAATTATCTTTTTTTAAACAGTAAAACTAAAAACCAAACACACCACC
TTCCTTGATCCCAGCTGGCCTCTCGCTGGCCGCACCTGTCACATCTCTCCTTCTTCTCTTTCACCACTCTTTCCCCCAGTCCATCCTGAA
GCTCCTGCACCCCCTTCCCGCCTTCCCCTCACTTCCCAAGAATACTCCAAACAAACTCTGAACCACGGAGACTTGGAGCAGTGGGAGACC
CCTCTCCCGTTTCTCGATACCTTCCTGGAGGAACGCGGGGACATCGGACCAACCCATACATCAAGCCAGAGAGCGGGGCTTAGGGAGACT
GGCCTTGGAGATGCCCCACTCCCTGTCTAAGCTCCGACAAGACTGTGACTTCCTCTGTGGCTGCTCTGCCTCCTCCCACTCACACCCAAG
TGGGCCTGGAGTAGAGACGGACAGGCTGGAGACGAGGCCGGAGTTTGAGAGGCCTCAGGGTGGGTGTGAGGCCATGGAGTCTGTATCCCT
GGGGAGGCGCTGGCCTCCTGGGCCTTGCCGTCCAGTGGGGAGTGGAGGGCAGAGGCCCTTTGGTCTGCTGGCTGTGGAGGGTGGGTTGCA

>85104_85104_4_SOCS7-SRCIN1_SOCS7_chr17_36533668_ENST00000577233_SRCIN1_chr17_36705446_ENST00000578925_length(amino acids)=692AA_BP=486
MVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQPP
PPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQ
QQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTRT
QSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIA
PIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRME
HYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTS
KKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SOCS7-SRCIN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SRCIN1	chr17:36533668	chr17:36705446	ENST00000264659		14	19	647_697	987.3333333333334	1184.0	SNAP25

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SOCS7-SRCIN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SOCS7-SRCIN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source