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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SOGA1-SAMHD1 (FusionGDB2 ID:85139)

Fusion Gene Summary for SOGA1-SAMHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: SOGA1-SAMHD1
Fusion gene ID: 85139
HgeneTgene
Gene symbol

SOGA1

SAMHD1

Gene ID

140710

25939

Gene namesuppressor of glucose, autophagy associated 1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
SynonymsC20orf117|KIAA0889|SOGACHBL2|DCIP|HDDC1|MOP-5|SBBI88|hSAMHD1
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein SOGA1SOGA family member 1suppressor of glucose by autophagysuppressor of glucose from autophagysuppressor of glucose, autophagy-associated protein 1deoxynucleoside triphosphate triphosphohydrolase SAMHD1SAM domain and HD domain 1SAM domain and HD domain-containing protein 1dNTPasedendritic cell-derived IFNG-induced proteinmonocyte protein 5
Modification date2020031320200313
UniProtAcc

O94964

.
Ensembl transtripts involved in fusion geneENST00000237536, ENST00000357779, 
ENST00000456801, ENST00000279034, 
ENST00000373694, ENST00000262878, 
Fusion gene scores* DoF score9 X 10 X 7=6306 X 7 X 5=210
# samples 1511
** MAII scorelog2(15/630*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/210*10)=-0.932885804141463
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOGA1 [Title/Abstract] AND SAMHD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSOGA1(35457456)-SAMHD1(35547922), # samples:2
Anticipated loss of major functional domain due to fusion event.SOGA1-SAMHD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SOGA1-SAMHD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSAMHD1

GO:0000724

double-strand break repair via homologous recombination

28834754|29670289

TgeneSAMHD1

GO:0006203

dGTP catabolic process

24217394

TgeneSAMHD1

GO:0006974

cellular response to DNA damage stimulus

28834754|29670289

TgeneSAMHD1

GO:0009264

deoxyribonucleotide catabolic process

23601106|26294762

TgeneSAMHD1

GO:0045088

regulation of innate immune response

29670289

TgeneSAMHD1

GO:0046061

dATP catabolic process

24141705

TgeneSAMHD1

GO:0051289

protein homotetramerization

23601106|24217394|26294762

TgeneSAMHD1

GO:0051607

defense response to virus

23601106|26294762

TgeneSAMHD1

GO:0060339

negative regulation of type I interferon-mediated signaling pathway

29670289

TgeneSAMHD1

GO:0110025

DNA strand resection involved in replication fork processing

28834754|29670289


check buttonFusion gene breakpoints across SOGA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SAMHD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A140-01ASOGA1chr20

35421652

-SAMHD1chr20

35563592

-
ChimerDB4BRCATCGA-OL-A5D7-01ASOGA1chr20

35457457

-SAMHD1chr20

35547922

-
ChimerDB4BRCATCGA-OL-A5D7SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
ChimerDB4OVTCGA-04-1517-01ASOGA1chr20

35467620

-SAMHD1chr20

35547922

-
ChimerDB4OVTCGA-04-1517SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
ChimerDB4OVTCGA-23-1120-01ASOGA1chr20

35407338

-SAMHD1chr20

35533826

-
ChimerDB4OVTCGA-23-1120-01ASOGA1chr20

35412288

-SAMHD1chr20

35532652

-
ChimerDB4OVTCGA-23-1120-01ASOGA1chr20

35421652

-SAMHD1chr20

35532652

-


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Fusion Gene ORF analysis for SOGA1-SAMHD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000237536ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
5CDS-5UTRENST00000357779ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
5CDS-5UTRENST00000456801ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
5CDS-intronENST00000237536ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
5CDS-intronENST00000357779ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
5CDS-intronENST00000456801ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
Frame-shiftENST00000279034ENST00000262878SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
Frame-shiftENST00000279034ENST00000262878SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
Frame-shiftENST00000279034ENST00000262878SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
Frame-shiftENST00000279034ENST00000262878SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
Frame-shiftENST00000279034ENST00000373694SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
Frame-shiftENST00000279034ENST00000373694SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
Frame-shiftENST00000279034ENST00000373694SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
Frame-shiftENST00000279034ENST00000373694SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
Frame-shiftENST00000357779ENST00000262878SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000262878SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000262878SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000262878SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
Frame-shiftENST00000357779ENST00000373694SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000373694SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000373694SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
Frame-shiftENST00000357779ENST00000373694SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
Frame-shiftENST00000456801ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
Frame-shiftENST00000456801ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
In-frameENST00000237536ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
In-frameENST00000237536ENST00000262878SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
In-frameENST00000237536ENST00000262878SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
In-frameENST00000237536ENST00000262878SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
In-frameENST00000237536ENST00000262878SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
In-frameENST00000237536ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
In-frameENST00000237536ENST00000373694SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
In-frameENST00000237536ENST00000373694SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
In-frameENST00000237536ENST00000373694SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
In-frameENST00000237536ENST00000373694SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
intron-3CDSENST00000237536ENST00000262878SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-3CDSENST00000237536ENST00000262878SOGA1chr20

35412288

-SAMHD1chr20

35532652

-
intron-3CDSENST00000279034ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
intron-3CDSENST00000279034ENST00000262878SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-3CDSENST00000279034ENST00000262878SOGA1chr20

35412288

-SAMHD1chr20

35532652

-
intron-3CDSENST00000279034ENST00000262878SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
intron-3CDSENST00000357779ENST00000262878SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-3CDSENST00000357779ENST00000262878SOGA1chr20

35412288

-SAMHD1chr20

35532652

-
intron-3CDSENST00000456801ENST00000262878SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
intron-3CDSENST00000456801ENST00000262878SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
intron-3CDSENST00000456801ENST00000262878SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
intron-3CDSENST00000456801ENST00000262878SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
intron-3CDSENST00000456801ENST00000262878SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-3CDSENST00000456801ENST00000262878SOGA1chr20

35412288

-SAMHD1chr20

35532652

-
intron-3CDSENST00000456801ENST00000373694SOGA1chr20

35457457

-SAMHD1chr20

35547922

-
intron-3CDSENST00000456801ENST00000373694SOGA1chr20

35457456

-SAMHD1chr20

35547922

-
intron-3CDSENST00000456801ENST00000373694SOGA1chr20

35467620

-SAMHD1chr20

35547922

-
intron-3CDSENST00000456801ENST00000373694SOGA1chr20

35467619

-SAMHD1chr20

35547922

-
intron-5UTRENST00000279034ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35563592

-
intron-intronENST00000237536ENST00000373694SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-intronENST00000237536ENST00000373694SOGA1chr20

35412288

-SAMHD1chr20

35532652

-
intron-intronENST00000279034ENST00000373694SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-intronENST00000279034ENST00000373694SOGA1chr20

35412288

-SAMHD1chr20

35532652

-
intron-intronENST00000279034ENST00000373694SOGA1chr20

35421652

-SAMHD1chr20

35532652

-
intron-intronENST00000357779ENST00000373694SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-intronENST00000357779ENST00000373694SOGA1chr20

35412288

-SAMHD1chr20

35532652

-
intron-intronENST00000456801ENST00000373694SOGA1chr20

35407338

-SAMHD1chr20

35533826

-
intron-intronENST00000456801ENST00000373694SOGA1chr20

35412288

-SAMHD1chr20

35532652

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000237536SOGA1chr2035421652-ENST00000262878SAMHD1chr2035563592-9411517519267072171
ENST00000237536SOGA1chr2035421652-ENST00000262878SAMHD1chr2035532652-8349517519256451817

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000237536ENST00000262878SOGA1chr2035421652-SAMHD1chr2035563592-0.0042120910.9957879
ENST00000237536ENST00000262878SOGA1chr2035421652-SAMHD1chr2035532652-0.0066018440.9933982

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Fusion Genomic Features for SOGA1-SAMHD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SOGA1-SAMHD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:35457456/chr20:35547922)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SOGA1

O94964

.
FUNCTION: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSAMHD1chr20:35421652chr20:35563592ENST00000262878216164_316116627.0DomainHD
TgeneSAMHD1chr20:35421652chr20:35563592ENST00000262878216137_145116627.0Nucleotide bindingGTP
TgeneSAMHD1chr20:35421652chr20:35563592ENST00000262878216352_354116627.0Nucleotide bindingdNTP
TgeneSAMHD1chr20:35457456chr20:35547922ENST00000262878516352_354232627.0Nucleotide bindingdNTP
TgeneSAMHD1chr20:35457457chr20:35547922ENST00000262878516352_354232627.0Nucleotide bindingdNTP
TgeneSAMHD1chr20:35467619chr20:35547922ENST00000262878516352_354232627.0Nucleotide bindingdNTP
TgeneSAMHD1chr20:35467620chr20:35547922ENST00000262878516352_354232627.0Nucleotide bindingdNTP
TgeneSAMHD1chr20:35421652chr20:35563592ENST00000262878216309_315116627.0RegionSubstrate binding
TgeneSAMHD1chr20:35421652chr20:35563592ENST00000262878216370_375116627.0RegionSubstrate binding
TgeneSAMHD1chr20:35457456chr20:35547922ENST00000262878516309_315232627.0RegionSubstrate binding
TgeneSAMHD1chr20:35457456chr20:35547922ENST00000262878516370_375232627.0RegionSubstrate binding
TgeneSAMHD1chr20:35457457chr20:35547922ENST00000262878516309_315232627.0RegionSubstrate binding
TgeneSAMHD1chr20:35457457chr20:35547922ENST00000262878516370_375232627.0RegionSubstrate binding
TgeneSAMHD1chr20:35467619chr20:35547922ENST00000262878516309_315232627.0RegionSubstrate binding
TgeneSAMHD1chr20:35467619chr20:35547922ENST00000262878516370_375232627.0RegionSubstrate binding
TgeneSAMHD1chr20:35467620chr20:35547922ENST00000262878516309_315232627.0RegionSubstrate binding
TgeneSAMHD1chr20:35467620chr20:35547922ENST00000262878516370_375232627.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSAMHD1chr20:35421652chr20:35532652ENST000002628781116164_316470627.0DomainHD
TgeneSAMHD1chr20:35421652chr20:35532652ENST00000262878111645_110470627.0DomainSAM
TgeneSAMHD1chr20:35421652chr20:35563592ENST0000026287821645_110116627.0DomainSAM
TgeneSAMHD1chr20:35457456chr20:35547922ENST00000262878516164_316232627.0DomainHD
TgeneSAMHD1chr20:35457456chr20:35547922ENST0000026287851645_110232627.0DomainSAM
TgeneSAMHD1chr20:35457457chr20:35547922ENST00000262878516164_316232627.0DomainHD
TgeneSAMHD1chr20:35457457chr20:35547922ENST0000026287851645_110232627.0DomainSAM
TgeneSAMHD1chr20:35467619chr20:35547922ENST00000262878516164_316232627.0DomainHD
TgeneSAMHD1chr20:35467619chr20:35547922ENST0000026287851645_110232627.0DomainSAM
TgeneSAMHD1chr20:35467620chr20:35547922ENST00000262878516164_316232627.0DomainHD
TgeneSAMHD1chr20:35467620chr20:35547922ENST0000026287851645_110232627.0DomainSAM
TgeneSAMHD1chr20:35421652chr20:35532652ENST000002628781116137_145470627.0Nucleotide bindingGTP
TgeneSAMHD1chr20:35421652chr20:35532652ENST000002628781116352_354470627.0Nucleotide bindingdNTP
TgeneSAMHD1chr20:35457456chr20:35547922ENST00000262878516137_145232627.0Nucleotide bindingGTP
TgeneSAMHD1chr20:35457457chr20:35547922ENST00000262878516137_145232627.0Nucleotide bindingGTP
TgeneSAMHD1chr20:35467619chr20:35547922ENST00000262878516137_145232627.0Nucleotide bindingGTP
TgeneSAMHD1chr20:35467620chr20:35547922ENST00000262878516137_145232627.0Nucleotide bindingGTP
TgeneSAMHD1chr20:35421652chr20:35532652ENST000002628781116309_315470627.0RegionSubstrate binding
TgeneSAMHD1chr20:35421652chr20:35532652ENST000002628781116370_375470627.0RegionSubstrate binding


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Fusion Gene Sequence for SOGA1-SAMHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85139_85139_1_SOGA1-SAMHD1_SOGA1_chr20_35421652_ENST00000237536_SAMHD1_chr20_35532652_ENST00000262878_length(transcript)=8349nt_BP=5175nt
CGGGCCGCAGCCGGACTCGGAGCCCGAGGGAGCGATCGGCGTGCGGGCGGCGGGGGCCCGGGCGCGCTCCGGGGGCGCGGCGAGGCCGAG
GGGGCGGGCGCCGGGCGGAGCCGCAGCCGGAGCCGGGGCGCCTGGAGGCGGTCGGGCCGCACTCTCCGAGCCCAGAGCAGCGGAGAGACC
GCGCGGCGGGGCTTGGGACGGGGACGCGGTGTCGGGGCCGAGGTGGGCCGAGAGCAGCCGCAGCCCCAGCGGCCGGAGCCGCGCCGGGTC
CCTCCCCAGGGACGTCGAGGCCGGGCGGGCCTGGGCCATGCGCGCAGCTCGCTGAGGCCGAGGGAGGCCGCGATGGAGGCGCCGGCGGCC
GAGCCCCCGGTCCGGGGCTGCGGTCCCCAGCCCGCGCCTGCACCCGCGCCTGCCCCGGAGAGGAAAAAGAGCCACCGCGCGCCGTCGCCG
GCCCGGCCCAAAGACGTGGCCGGCTGGTCGCTGGCTAAGGGCCGCCGCGGCCCAGGCCCGGGCTCAGCAGTCGCCTGCAGCGCCGCGTTC
TCCTCACGGCCGGACAAGAAGGGGCGCGCAGTGGCTCCCGGGGCGCGCGGTGCGGGTGTGCGGGTGGCCGGGGTCCGCACCGGGGTCCGT
GCCAAGGGCCGTCCGCGCTCGGGTGCGGGGCCGCGACCGCCACCGCCGCCCCCCAGCCTCACGGATAGCAGCTCGGAGGTGTCGGACTGC
GCGTCGGAGGAGGCGCGCCTGCTGGGCCTGGAGCTGGCGCTGAGCAGCGACGCCGAGTCCGCGGCCGGGGGCCCGGCGGGGGTCCGTACG
GGGCAGCCGGCCCAGCCCGCGCCCTCCGCGCAGCAGCCCCCGCGGCCGCCCGCCTCCCCGGACGAGCCGTCGGTGGCCGCGTCGTCGGTG
GGCAGCAGCCGCTTGCCGCTCAGCGCCTCGCTTGCCTTCTCCGACCTCACCGAGGAGATGCTGGACTGCGGGCCCAGCGGCTTGGTGCGG
GAGCTGGAGGAGCTGCGCTCGGAGAACGACTATCTCAAGGACGAGATTGAGGAGCTGCGGGCCGAGATGCTGGAGATGCGGGACGTCTAT
ATGGAGGAGGACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGCCGCATCCTGCAGTACCGGCTGCGC
AAAGCCGAGCGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGTCTGGAGCAGGATGTCAAGGTCTCT
AAGGACATCTCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAGGAGGAGAACGAAGAGCTTCGTCAG
CGGCTCATCGAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGCATTCCTTGAAGAAAAGAGGAACCCGC
TCCCTGGGGAAGGCCGATAAGAAGACTTTGGTGCAGGAGGACAGTGCAGACCTGAAGTGCCAGTTGCACTTTGCAAAGGAGGAGTCAGCC
CTCATGTGCAAGAAGCTCACTAAGCTTGCCAAGGAGAATGACAGCATGAAGGAGGAGCTGCTGAAGTACCGCTCGCTCTATGGGGACCTG
GACAGCGCGCTGTCAGCCGAGGAGCTGGCCGATGCCCCCCACTCGCGGGAGACCGAGCTGAAGGTGCACCTGAAGCTGGTGGAGGAGGAA
GCCAACCTGCTGAGCCGCCGCATCGTGGAGCTGGAGGTGGAGAACCGAGGCCTGCGGGCTGAGATGGACGACATGAAGGATCATGGAGGT
GGCTGTGGGGGTCCTGAGGCACGCCTGGCCTTCTCCGCGCTGGGTGGCGGAGAGTGCGGGGAGAGCTTGGCAGAGCTGCGGCGACACCTG
CAGTTTGTCGAAGAGGAGGCCGAGCTGCTGCGGCGCTCCTCTGCCGAGCTCGAGGACCAGAACAAGCTGCTGCTGAACGAGCTGGCCAAG
TTCCGCTCGGAGCACGAGCTGGACGTGGCGCTGTCGGAGGACAGTTGTTCTGTGCTCAGCGAACCTTCACAGGAGGAGCTGGCGGCCGCC
AAGCTGCAGATCGGCGAGCTCAGCGGCAAGGTCAAGAAGCTGCAGTACGAGAACCGCGTGCTCCTCTCCAACCTCCAGCGCTGTGACCTC
GCCTCCTGCCAGAGTACGCGGCCCATGCTGGAGACGGACGCCGAGGCCGGGGACTCTGCCCAGTGTGTGCCTGCTCCCCTGGGCGAGACA
CACGAGTCCCATGCGGTCCGACTCTGCAGAGCCAGGGAGGCCGAGGTGCTGCCTGGGCTGAGAGAGCAGGCCGCCCTGGTCAGTAAGGCC
ATCGATGTCCTGGTGGCTGATGCCAATGGCTTCACGGCTGGCCTCCGGCTGTGTCTGGACAACGAGTGTGCTGACTTCCGGCTGCATGAG
GCCCCCGACAACAGCGAGGGCCCCAGGGACACCAAGCTCATCCATGCCATCCTGGTGCGCCTGAGCGTGCTGCAGCAGGAGCTGAATGCC
TTCACGCGGAAGGCAGATGCAGTCCTCGGGTGCTCTGTCAAGGAACAGCAGGAGTCCTTCTCATCACTGCCCCCCTTGGGCTCCCAGGGG
CTCTCTAAGGAGATTCTTCTGGCAAAAGACCTTGGCTCAGACTTTCAGCCACCTGACTTCAGGGACCTGCCGGAATGGGAGCCCAGGATC
CGAGAGGCTTTCCGCACTGGTGACTTGGACTCTAAGCCCGACCCCAGCCGGAGCTTCAGGCCTTACCGAGCTGAAGACAATGATTCCTAT
GCCTCTGAGATCAAGGAGCTGCAGCTGGTGCTGGCTGAGGCCCACGACAGCCTCCGGGGCTTGCAAGAGCAGCTCTCCCAGGAGCGGCAG
CTACGAAAGGAGGAGGCCGACAATTTCAACCAGAAAATGGTCCAGCTGAAGGAGGACCAGCAGAGGGCGCTCCTGAGGCGGGAGTTTGAG
CTGCAGAGTCTGAGCCTCCAGCGGAGGCTGGAGCAGAAATTCTGGAGCCAGGAGAAGAACATGCTGGTGCAGGAGTCCCAGCAATTCAAG
CACAACTTCCTGCTGCTCTTCATGAAGCTCAGGTGGTTCCTCAAGCGCTGGCGGCAGGGCAAGGTTTTGCCCAGCGAAGGGGATGACTTC
CTCGAGGTGAACAGCATGAAGGAGCTGTACTTGCTGATGGAGGAAGAGGAGATAAACGCTCAGCATTCTGATAACAAGGCCTGCACGGGG
GACAGCTGGACCCAGAACACGCCCAATGAGTACATCAAGACACTGGCCGACATGAAGGTGACGCTGAAGGAGCTGTGCTGGCTGCTCCGG
GATGAACGCCGTGGTCTGACGGAGCTTCAGCAACAGTTTGCCAAGGCCAAGGCTACCTGGGAGACAGAGCGGGCAGAGCTCAAGGGCCAT
ACCTCCCAGATGGAGCTGAAGACAGGGAAGGGGGCCGGGGAGCGGGCAGGGCCCGACTGGAAGGCAGCCCTACAGCGGGAGCGTGAGGAG
CAGCAGCACCTCCTAGCTGAGTCCTACAGCGCTGTCATGGAGCTGACTCGGCAGCTGCAGATCAGTGAGCGCAACTGGAGCCAGGAAAAG
CTGCAGCTGGTGGAGCGGCTGCAGGGTGAGAAGCAGCAGGTGGAGCAGCAGGTGAAGGAGCTGCAGAACCGCCTAAGCCAGCTGCAGAAG
GCTGCCGACCCCTGGGTCCTGAAGCACTCGGAGCTGGAGAAGCAGGACAACAGCTGGAAGGAGACACGCAGTGAGAAGATCCACGACAAG
GAGGCTGTTTCCGAAGTTGAGCTTGGAGGAAATGGTTTAAAGAGAACCAAATCTGTTTCTTCCATGTCTGAGTTTGAAAGTTTGCTCGAC
TGTTCCCCTTACCTTGCTGGCGGAGATGCCCGGGGCAAGAAGCTGCCTAACAACCCTGCCTTTGGCTTTGTGAGCTCCGAGCCAGGGGAT
CCAGAGAAAGACACCAAGGAGAAGCCTGGGCTCTCGTCGAGGGACTGCAACCACCTGGGTGCCCTGGCCTGCCAGGACCCCCCAGGGAGG
CAGATGCAGCGCAGCTACACGGCTCCTGACAAGACGGGCATCCGAGTCTACTATAGTCCCCCGGTGGCCCGGCGCCTCGGAGTCCCTGTG
GTTCATGACAAAGAGGGCAAGATCATTATCGAGCCCGGCTTCCTCTTCACCACAGCCAAGCCCAAAGAGTCGGCCGAGGCTGATGGGCTG
GCTGAGAGCTCCTATGGTCGGTGGCTCTGCAACTTCTCACGGCAGCGCCTGGACGGAGGCTCAGCGGGCAGCCCCTCGGCGGCCGGGCCT
GGCTTCCCAGCGGCCCTGCATGACTTTGAGATGTCAGGCAACATGAGTGATGACATGAAGGAGATCACCAACTGTGTGCGCCAGGCCATG
CGCTCCGGCTCACTGGAGAGGAAAGTGAAGAGCACATCCAGCCAGACGGTGGGCCTGGCCAGTGTGGGCACACAGACCATCCGCACGGTC
AGCGTGGGCCTGCAGACCGACCCACCCCGCAGCAGCCTCCATGGCAAGGCCTGGTCACCCCGCAGCTCTTCGCTCGTGTCTGTGCGCAGC
AAGCAGATCTCCTCCTCCCTGGACAAGGTCCATTCGCGCATCGAGCGGCCCTGCTGCTCCCCCAAGTATGGCTCACCAAAGCTCCAGAGG
CGGTCTGTGTCCAAGCTGGACAGCAGCAAGGACCGCAGCCTGTGGAACCTGCACCAGGGCAAGCAGAACGGCTCGGCCTGGGCCCGCTCC
ACCACCACGCGGGACAGCCCTGTATTGAGAAACATCAACGATGGACTCTCCAGCCTCTTCAGTGTGGTGGAGCACTCAGGGAGCACGGAG
TCTGTCTGGAAACTAGGCATGTCTGAGACGCGGGCCAAGCCCGAGCCTCCCAAGTACGGCATTGTGCAGGAATTCTTCCGTAATGTGTGT
GGCCGGGCACCGAGCCCCACCTCATCAGCAGGAGAGGAGGGCACCAAGAAGCCAGAGCCCCTCTCCCCAGCCAGCTACCATCAGCCAGAG
GGTGTGGCCAGGATCCTGAACAAGAAGGCAGCCAAGTTGGGCAGCAGTGAGGAGGTCAGACTCACCATGCTCCCCCAGGTGGGGAAGGAT
GGTGTCCTCCGGGACGGAGATGGAGCCGTGGTCCTTCCCAATGAGGAGGACTATGAATCTCTTCCAAAAGAGGTTGCCAGTGCTAAACCC
AAAGTATTGCTAGACGTGAAACTGAAGGCTGAAGATTTTATAGTGGATGTTATCAACATGGATTATGGAATGCAAGAAAAGAATCCAATT
GATCATGTTAGCTTCTATTGTAAGACTGCCCCCAACAGAGCAATCAGGATTACTAAAAACCAGGTTTCACAACTTCTGCCAGAGAAATTT
GCAGAGCAGCTGATTCGAGTATATTGTAAGAAGGTGGACAGAAAGAGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGTGCAGAC
AGAAATTTCACCAAGCCGCAGGATGGCGATGTTATAGCCCCACTCATAACACCTCAAAAAAAGGAATGGAACGACAGTACTTCAGTCCAA
AATCCAACTCGCCTCCGAGAAGCATCCAAAAGCAGAGTCCAGCTTTTTAAAGATGACCCAATGTGAATGTCTGTAGTCAGTTGTTTACAA
ACTCCCTCTCCTGCACAATTCATTTAGAGGCTTCAATCATAGAATTCTGCAAATTAATGACAACTCATGCTTTAATTTTGTATTTTGAAT
GTACACGCATGCTGAAGCTAAGTAACTTTTAATCAAAGAAATAAGATGGTATTAGGCAAATCTTACTATACTATGAAAAGCATTACCTTG
CCTATTTTTAATATTATTAAAGCCTTTCTCCTTCAGTAGTCTATTTTCTTAGAATAACAACTCTTTTATCTATTCTGAACTCTATTTTTT
TTCTTTTTTAAGAGACAAGGTTTTGCTCTGTTGCCCAGCTTGGACTCGAACTTTCCTGGGCTCAAGCGACCCTCCTGCCTCAGCCCCCCA
AGTAGCTGGGACTAAAGTCATGTGCCACCACACCCAGCTTACTCTGAACTTTTATGACAGATGATTGTTTTTTGTTTTTAATGTAGAAAT
GAGACAAGGGTACAAATTGGAACTAGAAATTGACATTGTCATTGACAAACATGGCTAAAAACAAAACATCAAATCCTGCCCCCGTGAAGA
GTTCCCTGTCACCTCAAGTTTGAGGATAGTCCTCTAAGAGTGACCTAAGCATAAGTGAAAGACACCTCCCCTCACCCTTCTAGCCCCCTA
CAAGGTGCCAGGTTGGGGTAAAGAGTTGGAGATGATGGCCAGGAGTGGCCTCCAACACGCTGGTGAGAGGCCTGATTAGGTTTTGGGGAA
GATCTGAGAGCTCTGGCCTCTTCGTGAGTGGAACATAAAGCCGCCTCTTGTTGGGAGATCCTACCCCAGTGACAGAGGAATCCCCCAAAC
TAGGCTGTGCCCTGGCTCCGTGGCGGCTCCAGACCCGGGTAGTGCCTTTGTCCCCTGAATACTCACTCCCCCGGTCCAGAGGGCCTTCCC
ACTGCCCAGCCTGGAGAAGGCCTCCCCTGACCTGCTCTCTCAGTATCCTGGAGAGCTGGCCAGAGGCCATCACAGGCATCATCCTCAGAG
CTCCTCAGACCTGGGACTTTGTTTTTGCTGGTTCAGTGCATTTTGTGTATTTAAGAGCAAACACTAGCCAGGCGTGGCGGCGTGTGCCTG
TAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATTGCTCGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCACGCCATTGCACT
CCAGCCTGGGTGACAGAGTGAGACTCCATCTCCAAAAAAAAAAGCACAAACACTGCACTGCCTGTGCTGAAATTAGTGACCACCCAGTGG
GCTCCAGGCTCCGCTAGGTAACTTCGTTTTCCCAGCAGTGGAGTGGGCACCACCTTGGTGGGGCAGTGCCCCTGTGCCCAGGGCACACCT
CATTCCCAGTTCTATAGCAATTCACCAAGAACAAAGTCTGCAGTTAGAGCCAAAGCTGGTGGTGGCCAGAGGGTGCTGAAGATACAGGCC
AGTGGGGATGGGAGCCATGAGCCCCGAATGTCTTCTGCTCTGATGCTCCCCGGACTAAGCCTCCCTGGCACACTGGGAGTGAGGGGCAGC
CTGAGCAAGTAGGGGAACTCAGACCACAGGCCAGCAGATTTCCCAGCAGTCCATCACTGGCCACCGTGTAGCCAGATTCTGTTCCGTCCA
CACTGGGGTGAAGAGTACTTGGAATGTCTGCCATCCTGTATGATCACCCCACCCCCTGTCCATCCATCAGTAGATAATAAGGGTTGGTTA
CAATTCATAAGAGAATAGTTAAAACACTTCTCCTCTCATGCCTACCATGGTGCTGTATCAAGGGGATTTGTTCACATATGGGCTCAGCAA
CGCACAAGTGAGGTCAGCCATGGCACTAGGTCATTCCCATTTTAGCCAAGGTGCCTCTATAGGGGTCAGACATCATGTGCCCAGACCTAA
GGTCAGGAATGTCATATTTTTCTGTTAAAATCATTTTATTTCTGTGTATCTTACCTTTAAATCATTGTGGTTTACTCTGAGATTCTGTAG
TCCTAATATTGTATCATTGTGCTGTCTGCAAAACAACTTGAATCTATTTTGTTTGCATCTTTTGTTACATGTAACGCAGCTGTACTTTAT
GTTCTTTGCAACTGTTTCCATTATGAGAACGCTGTGCTATTTACAAGGTTACATTTTTCTTGGCCAGGCGAGGTGGTCATGCCTGTAATC
CCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGAGGTAAAGAGTTGAGACCAGCCTGGCTAGCATGGCGAAACCCAGTCTCTACTA
AAAATACAAAAATTAGCCGGGTGAAATTAGCCGGGCGTGGTGGTGTGTGCTTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATC
GCTTGAATCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATCAGGCCACTGCACTCCAGCCTCGGGGTCAAGAGCGAAACTCTGTCTCAAAC
AAAAAGAAAGAAAGGAAGGAAGGAAGGAGGGAAGGAAGGAAGGAAAGAGAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAGAAAGAAAT
ATCTTTGCTATTTGTATAAAAATGGAAATTTTAACAGCTTAGCCTCTAGAGAGTTACTGAACGTGGTTACCTTGGGAATGTAAATAGAAC

>85139_85139_1_SOGA1-SAMHD1_SOGA1_chr20_35421652_ENST00000237536_SAMHD1_chr20_35532652_ENST00000262878_length(amino acids)=1817AA_BP=1661
MGRGRGVGAEVGREQPQPQRPEPRRVPPQGRRGRAGLGHARSSLRPREAAMEAPAAEPPVRGCGPQPAPAPAPAPERKKSHRAPSPARPK
DVAGWSLAKGRRGPGPGSAVACSAAFSSRPDKKGRAVAPGARGAGVRVAGVRTGVRAKGRPRSGAGPRPPPPPPSLTDSSSEVSDCASEE
ARLLGLELALSSDAESAAGGPAGVRTGQPAQPAPSAQQPPRPPASPDEPSVAASSVGSSRLPLSASLAFSDLTEEMLDCGPSGLVRELEE
LRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDIS
MRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCK
KLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGG
PEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQI
GELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVL
VADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKE
ILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE
EADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVN
SMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQM
ELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADP
WVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKD
TKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAEADGLAESS
YGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKSTSSQTVGLASVGTQTIRTVSVGL
QTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSSKDRSLWNLHQGKQNGSAWARSTTTR
DSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPKYGIVQEFFRNVCGRAPSPTSSAGEEGTKKPEPLSPASYHQPEGVAR
ILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEEDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS
FYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWNDSTSVQNPTR

--------------------------------------------------------------
>85139_85139_2_SOGA1-SAMHD1_SOGA1_chr20_35421652_ENST00000237536_SAMHD1_chr20_35563592_ENST00000262878_length(transcript)=9411nt_BP=5175nt
CGGGCCGCAGCCGGACTCGGAGCCCGAGGGAGCGATCGGCGTGCGGGCGGCGGGGGCCCGGGCGCGCTCCGGGGGCGCGGCGAGGCCGAG
GGGGCGGGCGCCGGGCGGAGCCGCAGCCGGAGCCGGGGCGCCTGGAGGCGGTCGGGCCGCACTCTCCGAGCCCAGAGCAGCGGAGAGACC
GCGCGGCGGGGCTTGGGACGGGGACGCGGTGTCGGGGCCGAGGTGGGCCGAGAGCAGCCGCAGCCCCAGCGGCCGGAGCCGCGCCGGGTC
CCTCCCCAGGGACGTCGAGGCCGGGCGGGCCTGGGCCATGCGCGCAGCTCGCTGAGGCCGAGGGAGGCCGCGATGGAGGCGCCGGCGGCC
GAGCCCCCGGTCCGGGGCTGCGGTCCCCAGCCCGCGCCTGCACCCGCGCCTGCCCCGGAGAGGAAAAAGAGCCACCGCGCGCCGTCGCCG
GCCCGGCCCAAAGACGTGGCCGGCTGGTCGCTGGCTAAGGGCCGCCGCGGCCCAGGCCCGGGCTCAGCAGTCGCCTGCAGCGCCGCGTTC
TCCTCACGGCCGGACAAGAAGGGGCGCGCAGTGGCTCCCGGGGCGCGCGGTGCGGGTGTGCGGGTGGCCGGGGTCCGCACCGGGGTCCGT
GCCAAGGGCCGTCCGCGCTCGGGTGCGGGGCCGCGACCGCCACCGCCGCCCCCCAGCCTCACGGATAGCAGCTCGGAGGTGTCGGACTGC
GCGTCGGAGGAGGCGCGCCTGCTGGGCCTGGAGCTGGCGCTGAGCAGCGACGCCGAGTCCGCGGCCGGGGGCCCGGCGGGGGTCCGTACG
GGGCAGCCGGCCCAGCCCGCGCCCTCCGCGCAGCAGCCCCCGCGGCCGCCCGCCTCCCCGGACGAGCCGTCGGTGGCCGCGTCGTCGGTG
GGCAGCAGCCGCTTGCCGCTCAGCGCCTCGCTTGCCTTCTCCGACCTCACCGAGGAGATGCTGGACTGCGGGCCCAGCGGCTTGGTGCGG
GAGCTGGAGGAGCTGCGCTCGGAGAACGACTATCTCAAGGACGAGATTGAGGAGCTGCGGGCCGAGATGCTGGAGATGCGGGACGTCTAT
ATGGAGGAGGACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGCCGCATCCTGCAGTACCGGCTGCGC
AAAGCCGAGCGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGTCTGGAGCAGGATGTCAAGGTCTCT
AAGGACATCTCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAGGAGGAGAACGAAGAGCTTCGTCAG
CGGCTCATCGAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGCATTCCTTGAAGAAAAGAGGAACCCGC
TCCCTGGGGAAGGCCGATAAGAAGACTTTGGTGCAGGAGGACAGTGCAGACCTGAAGTGCCAGTTGCACTTTGCAAAGGAGGAGTCAGCC
CTCATGTGCAAGAAGCTCACTAAGCTTGCCAAGGAGAATGACAGCATGAAGGAGGAGCTGCTGAAGTACCGCTCGCTCTATGGGGACCTG
GACAGCGCGCTGTCAGCCGAGGAGCTGGCCGATGCCCCCCACTCGCGGGAGACCGAGCTGAAGGTGCACCTGAAGCTGGTGGAGGAGGAA
GCCAACCTGCTGAGCCGCCGCATCGTGGAGCTGGAGGTGGAGAACCGAGGCCTGCGGGCTGAGATGGACGACATGAAGGATCATGGAGGT
GGCTGTGGGGGTCCTGAGGCACGCCTGGCCTTCTCCGCGCTGGGTGGCGGAGAGTGCGGGGAGAGCTTGGCAGAGCTGCGGCGACACCTG
CAGTTTGTCGAAGAGGAGGCCGAGCTGCTGCGGCGCTCCTCTGCCGAGCTCGAGGACCAGAACAAGCTGCTGCTGAACGAGCTGGCCAAG
TTCCGCTCGGAGCACGAGCTGGACGTGGCGCTGTCGGAGGACAGTTGTTCTGTGCTCAGCGAACCTTCACAGGAGGAGCTGGCGGCCGCC
AAGCTGCAGATCGGCGAGCTCAGCGGCAAGGTCAAGAAGCTGCAGTACGAGAACCGCGTGCTCCTCTCCAACCTCCAGCGCTGTGACCTC
GCCTCCTGCCAGAGTACGCGGCCCATGCTGGAGACGGACGCCGAGGCCGGGGACTCTGCCCAGTGTGTGCCTGCTCCCCTGGGCGAGACA
CACGAGTCCCATGCGGTCCGACTCTGCAGAGCCAGGGAGGCCGAGGTGCTGCCTGGGCTGAGAGAGCAGGCCGCCCTGGTCAGTAAGGCC
ATCGATGTCCTGGTGGCTGATGCCAATGGCTTCACGGCTGGCCTCCGGCTGTGTCTGGACAACGAGTGTGCTGACTTCCGGCTGCATGAG
GCCCCCGACAACAGCGAGGGCCCCAGGGACACCAAGCTCATCCATGCCATCCTGGTGCGCCTGAGCGTGCTGCAGCAGGAGCTGAATGCC
TTCACGCGGAAGGCAGATGCAGTCCTCGGGTGCTCTGTCAAGGAACAGCAGGAGTCCTTCTCATCACTGCCCCCCTTGGGCTCCCAGGGG
CTCTCTAAGGAGATTCTTCTGGCAAAAGACCTTGGCTCAGACTTTCAGCCACCTGACTTCAGGGACCTGCCGGAATGGGAGCCCAGGATC
CGAGAGGCTTTCCGCACTGGTGACTTGGACTCTAAGCCCGACCCCAGCCGGAGCTTCAGGCCTTACCGAGCTGAAGACAATGATTCCTAT
GCCTCTGAGATCAAGGAGCTGCAGCTGGTGCTGGCTGAGGCCCACGACAGCCTCCGGGGCTTGCAAGAGCAGCTCTCCCAGGAGCGGCAG
CTACGAAAGGAGGAGGCCGACAATTTCAACCAGAAAATGGTCCAGCTGAAGGAGGACCAGCAGAGGGCGCTCCTGAGGCGGGAGTTTGAG
CTGCAGAGTCTGAGCCTCCAGCGGAGGCTGGAGCAGAAATTCTGGAGCCAGGAGAAGAACATGCTGGTGCAGGAGTCCCAGCAATTCAAG
CACAACTTCCTGCTGCTCTTCATGAAGCTCAGGTGGTTCCTCAAGCGCTGGCGGCAGGGCAAGGTTTTGCCCAGCGAAGGGGATGACTTC
CTCGAGGTGAACAGCATGAAGGAGCTGTACTTGCTGATGGAGGAAGAGGAGATAAACGCTCAGCATTCTGATAACAAGGCCTGCACGGGG
GACAGCTGGACCCAGAACACGCCCAATGAGTACATCAAGACACTGGCCGACATGAAGGTGACGCTGAAGGAGCTGTGCTGGCTGCTCCGG
GATGAACGCCGTGGTCTGACGGAGCTTCAGCAACAGTTTGCCAAGGCCAAGGCTACCTGGGAGACAGAGCGGGCAGAGCTCAAGGGCCAT
ACCTCCCAGATGGAGCTGAAGACAGGGAAGGGGGCCGGGGAGCGGGCAGGGCCCGACTGGAAGGCAGCCCTACAGCGGGAGCGTGAGGAG
CAGCAGCACCTCCTAGCTGAGTCCTACAGCGCTGTCATGGAGCTGACTCGGCAGCTGCAGATCAGTGAGCGCAACTGGAGCCAGGAAAAG
CTGCAGCTGGTGGAGCGGCTGCAGGGTGAGAAGCAGCAGGTGGAGCAGCAGGTGAAGGAGCTGCAGAACCGCCTAAGCCAGCTGCAGAAG
GCTGCCGACCCCTGGGTCCTGAAGCACTCGGAGCTGGAGAAGCAGGACAACAGCTGGAAGGAGACACGCAGTGAGAAGATCCACGACAAG
GAGGCTGTTTCCGAAGTTGAGCTTGGAGGAAATGGTTTAAAGAGAACCAAATCTGTTTCTTCCATGTCTGAGTTTGAAAGTTTGCTCGAC
TGTTCCCCTTACCTTGCTGGCGGAGATGCCCGGGGCAAGAAGCTGCCTAACAACCCTGCCTTTGGCTTTGTGAGCTCCGAGCCAGGGGAT
CCAGAGAAAGACACCAAGGAGAAGCCTGGGCTCTCGTCGAGGGACTGCAACCACCTGGGTGCCCTGGCCTGCCAGGACCCCCCAGGGAGG
CAGATGCAGCGCAGCTACACGGCTCCTGACAAGACGGGCATCCGAGTCTACTATAGTCCCCCGGTGGCCCGGCGCCTCGGAGTCCCTGTG
GTTCATGACAAAGAGGGCAAGATCATTATCGAGCCCGGCTTCCTCTTCACCACAGCCAAGCCCAAAGAGTCGGCCGAGGCTGATGGGCTG
GCTGAGAGCTCCTATGGTCGGTGGCTCTGCAACTTCTCACGGCAGCGCCTGGACGGAGGCTCAGCGGGCAGCCCCTCGGCGGCCGGGCCT
GGCTTCCCAGCGGCCCTGCATGACTTTGAGATGTCAGGCAACATGAGTGATGACATGAAGGAGATCACCAACTGTGTGCGCCAGGCCATG
CGCTCCGGCTCACTGGAGAGGAAAGTGAAGAGCACATCCAGCCAGACGGTGGGCCTGGCCAGTGTGGGCACACAGACCATCCGCACGGTC
AGCGTGGGCCTGCAGACCGACCCACCCCGCAGCAGCCTCCATGGCAAGGCCTGGTCACCCCGCAGCTCTTCGCTCGTGTCTGTGCGCAGC
AAGCAGATCTCCTCCTCCCTGGACAAGGTCCATTCGCGCATCGAGCGGCCCTGCTGCTCCCCCAAGTATGGCTCACCAAAGCTCCAGAGG
CGGTCTGTGTCCAAGCTGGACAGCAGCAAGGACCGCAGCCTGTGGAACCTGCACCAGGGCAAGCAGAACGGCTCGGCCTGGGCCCGCTCC
ACCACCACGCGGGACAGCCCTGTATTGAGAAACATCAACGATGGACTCTCCAGCCTCTTCAGTGTGGTGGAGCACTCAGGGAGCACGGAG
TCTGTCTGGAAACTAGGCATGTCTGAGACGCGGGCCAAGCCCGAGCCTCCCAAGTACGGCATTGTGCAGGAATTCTTCCGTAATGTGTGT
GGCCGGGCACCGAGCCCCACCTCATCAGCAGGAGAGGAGGGCACCAAGAAGCCAGAGCCCCTCTCCCCAGCCAGCTACCATCAGCCAGAG
GGTGTGGCCAGGATCCTGAACAAGAAGGCAGCCAAGTTGGGCAGCAGTGAGGAGGTCAGACTCACCATGCTCCCCCAGGTGGGGAAGGAT
GGTGTCCTCCGGGACGGAGATGGAGCCGTGGTCCTTCCCAATGAGGTAATTAATGATCCTATCCATGGCCACATTGAGCTCCACCCTCTC
CTCGTCCGAATCATTGATACACCTCAATTTCAACGTCTTCGATACATCAAACAGCTGGGAGGTGGTTACTATGTTTTTCCAGGAGCTTCA
CACAATCGATTTGAGCATAGTCTAGGGGTGGGGTATCTAGCAGGATGTCTAGTTCACGCACTGGGTGAAAAACAACCAGAGCTGCAGATA
AGTGAACGAGATGTTCTCTGTGTTCAGATTGCTGGACTTTGTCATGATCTCGGTCATGGGCCATTTTCTCACATGTTTGATGGACGATTT
ATTCCACTTGCTCGCCCGGAGGTGAAATGGACGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAG
CCTGTCATGGAACAATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAA
GATTCATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGAC
AAATGGGATTATTTTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGT
GAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGT
AGAGCTTATCAACACAAAGTTGGCAACATTATTGATACAATGATTACAGATGCTTTCCTCAAAGCAGATGACTACATAGAGATTACAGGT
GCTGGAGGAAAAAAGTATCGCATTTCTACAGCAATTGACGACATGGAAGCCTATACTAAGCTGACAGATAACATTTTTCTGGAGATTTTA
TACTCTACTGATCCCAAATTGAAAGACGCACGAGAGATTTTAAAACAAATTGAATACCGTAATCTATTCAAGTATGTGGGTGAGACGCAG
CCAACAGGACAAATAAAGATTAAAAGGGAGGACTATGAATCTCTTCCAAAAGAGGTTGCCAGTGCTAAACCCAAAGTATTGCTAGACGTG
AAACTGAAGGCTGAAGATTTTATAGTGGATGTTATCAACATGGATTATGGAATGCAAGAAAAGAATCCAATTGATCATGTTAGCTTCTAT
TGTAAGACTGCCCCCAACAGAGCAATCAGGATTACTAAAAACCAGGTTTCACAACTTCTGCCAGAGAAATTTGCAGAGCAGCTGATTCGA
GTATATTGTAAGAAGGTGGACAGAAAGAGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGTGCAGACAGAAATTTCACCAAGCCG
CAGGATGGCGATGTTATAGCCCCACTCATAACACCTCAAAAAAAGGAATGGAACGACAGTACTTCAGTCCAAAATCCAACTCGCCTCCGA
GAAGCATCCAAAAGCAGAGTCCAGCTTTTTAAAGATGACCCAATGTGAATGTCTGTAGTCAGTTGTTTACAAACTCCCTCTCCTGCACAA
TTCATTTAGAGGCTTCAATCATAGAATTCTGCAAATTAATGACAACTCATGCTTTAATTTTGTATTTTGAATGTACACGCATGCTGAAGC
TAAGTAACTTTTAATCAAAGAAATAAGATGGTATTAGGCAAATCTTACTATACTATGAAAAGCATTACCTTGCCTATTTTTAATATTATT
AAAGCCTTTCTCCTTCAGTAGTCTATTTTCTTAGAATAACAACTCTTTTATCTATTCTGAACTCTATTTTTTTTCTTTTTTAAGAGACAA
GGTTTTGCTCTGTTGCCCAGCTTGGACTCGAACTTTCCTGGGCTCAAGCGACCCTCCTGCCTCAGCCCCCCAAGTAGCTGGGACTAAAGT
CATGTGCCACCACACCCAGCTTACTCTGAACTTTTATGACAGATGATTGTTTTTTGTTTTTAATGTAGAAATGAGACAAGGGTACAAATT
GGAACTAGAAATTGACATTGTCATTGACAAACATGGCTAAAAACAAAACATCAAATCCTGCCCCCGTGAAGAGTTCCCTGTCACCTCAAG
TTTGAGGATAGTCCTCTAAGAGTGACCTAAGCATAAGTGAAAGACACCTCCCCTCACCCTTCTAGCCCCCTACAAGGTGCCAGGTTGGGG
TAAAGAGTTGGAGATGATGGCCAGGAGTGGCCTCCAACACGCTGGTGAGAGGCCTGATTAGGTTTTGGGGAAGATCTGAGAGCTCTGGCC
TCTTCGTGAGTGGAACATAAAGCCGCCTCTTGTTGGGAGATCCTACCCCAGTGACAGAGGAATCCCCCAAACTAGGCTGTGCCCTGGCTC
CGTGGCGGCTCCAGACCCGGGTAGTGCCTTTGTCCCCTGAATACTCACTCCCCCGGTCCAGAGGGCCTTCCCACTGCCCAGCCTGGAGAA
GGCCTCCCCTGACCTGCTCTCTCAGTATCCTGGAGAGCTGGCCAGAGGCCATCACAGGCATCATCCTCAGAGCTCCTCAGACCTGGGACT
TTGTTTTTGCTGGTTCAGTGCATTTTGTGTATTTAAGAGCAAACACTAGCCAGGCGTGGCGGCGTGTGCCTGTAGTCCCAGCTACTTGGG
AGGCTGAGGCAGGAGGATTGCTCGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCACGCCATTGCACTCCAGCCTGGGTGACAGAG
TGAGACTCCATCTCCAAAAAAAAAAGCACAAACACTGCACTGCCTGTGCTGAAATTAGTGACCACCCAGTGGGCTCCAGGCTCCGCTAGG
TAACTTCGTTTTCCCAGCAGTGGAGTGGGCACCACCTTGGTGGGGCAGTGCCCCTGTGCCCAGGGCACACCTCATTCCCAGTTCTATAGC
AATTCACCAAGAACAAAGTCTGCAGTTAGAGCCAAAGCTGGTGGTGGCCAGAGGGTGCTGAAGATACAGGCCAGTGGGGATGGGAGCCAT
GAGCCCCGAATGTCTTCTGCTCTGATGCTCCCCGGACTAAGCCTCCCTGGCACACTGGGAGTGAGGGGCAGCCTGAGCAAGTAGGGGAAC
TCAGACCACAGGCCAGCAGATTTCCCAGCAGTCCATCACTGGCCACCGTGTAGCCAGATTCTGTTCCGTCCACACTGGGGTGAAGAGTAC
TTGGAATGTCTGCCATCCTGTATGATCACCCCACCCCCTGTCCATCCATCAGTAGATAATAAGGGTTGGTTACAATTCATAAGAGAATAG
TTAAAACACTTCTCCTCTCATGCCTACCATGGTGCTGTATCAAGGGGATTTGTTCACATATGGGCTCAGCAACGCACAAGTGAGGTCAGC
CATGGCACTAGGTCATTCCCATTTTAGCCAAGGTGCCTCTATAGGGGTCAGACATCATGTGCCCAGACCTAAGGTCAGGAATGTCATATT
TTTCTGTTAAAATCATTTTATTTCTGTGTATCTTACCTTTAAATCATTGTGGTTTACTCTGAGATTCTGTAGTCCTAATATTGTATCATT
GTGCTGTCTGCAAAACAACTTGAATCTATTTTGTTTGCATCTTTTGTTACATGTAACGCAGCTGTACTTTATGTTCTTTGCAACTGTTTC
CATTATGAGAACGCTGTGCTATTTACAAGGTTACATTTTTCTTGGCCAGGCGAGGTGGTCATGCCTGTAATCCCAGCACTTTGGGAGGCC
AAGGTGGGCGGATCACTTGAGGTAAAGAGTTGAGACCAGCCTGGCTAGCATGGCGAAACCCAGTCTCTACTAAAAATACAAAAATTAGCC
GGGTGAAATTAGCCGGGCGTGGTGGTGTGTGCTTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGCA
GAGGTTGCAGTGAGCCAAGATCAGGCCACTGCACTCCAGCCTCGGGGTCAAGAGCGAAACTCTGTCTCAAACAAAAAGAAAGAAAGGAAG
GAAGGAAGGAGGGAAGGAAGGAAGGAAAGAGAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAGAAAGAAATATCTTTGCTATTTGTATA
AAAATGGAAATTTTAACAGCTTAGCCTCTAGAGAGTTACTGAACGTGGTTACCTTGGGAATGTAAATAGAACTGCAAATTAAAATGACTG

>85139_85139_2_SOGA1-SAMHD1_SOGA1_chr20_35421652_ENST00000237536_SAMHD1_chr20_35563592_ENST00000262878_length(amino acids)=2171AA_BP=1661
MGRGRGVGAEVGREQPQPQRPEPRRVPPQGRRGRAGLGHARSSLRPREAAMEAPAAEPPVRGCGPQPAPAPAPAPERKKSHRAPSPARPK
DVAGWSLAKGRRGPGPGSAVACSAAFSSRPDKKGRAVAPGARGAGVRVAGVRTGVRAKGRPRSGAGPRPPPPPPSLTDSSSEVSDCASEE
ARLLGLELALSSDAESAAGGPAGVRTGQPAQPAPSAQQPPRPPASPDEPSVAASSVGSSRLPLSASLAFSDLTEEMLDCGPSGLVRELEE
LRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDIS
MRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCK
KLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGG
PEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQI
GELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVL
VADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKE
ILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKE
EADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVN
SMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQM
ELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADP
WVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKD
TKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAEADGLAESS
YGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKSTSSQTVGLASVGTQTIRTVSVGL
QTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSSKDRSLWNLHQGKQNGSAWARSTTTR
DSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPKYGIVQEFFRNVCGRAPSPTSSAGEEGTKKPEPLSPASYHQPEGVAR
ILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRF
EHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVME
QYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDN
ELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTD
PKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTA
PNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWNDSTSVQNPTRLREASK

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Fusion Gene PPI Analysis for SOGA1-SAMHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SOGA1-SAMHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SOGA1-SAMHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource