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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SORBS2-ASPH (FusionGDB2 ID:85185)

Fusion Gene Summary for SORBS2-ASPH

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2-ASPH
Fusion gene ID: 85185
HgeneTgene
Gene symbol

SORBS2

ASPH

Gene ID

8470

444

Gene namesorbin and SH3 domain containing 2aspartate beta-hydroxylase
SynonymsARGBP2|PRO0618AAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin
Cytomap

4q35.1

8q12.3

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2aspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase
Modification date2020031320200315
UniProtAcc.

Q6ICH7

Ensembl transtripts involved in fusion geneENST00000319471, ENST00000355634, 
ENST00000393528, ENST00000448662, 
ENST00000449407, ENST00000284776, 
ENST00000431808, ENST00000437304, 
ENST00000418609, ENST00000498125, 
ENST00000356457, ENST00000379449, 
ENST00000389204, ENST00000445642, 
ENST00000517661, ENST00000517847, 
ENST00000517856, ENST00000517903, 
ENST00000518068, ENST00000522603, 
ENST00000522835, ENST00000522919, 
ENST00000523897, ENST00000379454, 
ENST00000541428, 
Fusion gene scores* DoF score16 X 20 X 8=256017 X 17 X 5=1445
# samples 2119
** MAII scorelog2(21/2560*10)=-3.60768257722124
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1445*10)=-2.92699816905709
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORBS2 [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSORBS2(186599576)-ASPH(62489417), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

TgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check buttonFusion gene breakpoints across SORBS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7901SORBS2chr4

186599576

-ASPHchr8

62489417

-


Top

Fusion Gene ORF analysis for SORBS2-ASPH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319471ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000319471ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000355634ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000393528ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000448662ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5CDS-intronENST00000449407ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-3CDSENST00000284776ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-3CDSENST00000284776ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-3CDSENST00000431808ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-3CDSENST00000431808ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-3CDSENST00000437304ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-3CDSENST00000437304ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000284776ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000431808ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
5UTR-intronENST00000437304ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000319471ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000319471ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000355634ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000355634ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000448662ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000448662ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000449407ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
Frame-shiftENST00000449407ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
In-frameENST00000393528ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
In-frameENST00000393528ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-3CDSENST00000418609ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-3CDSENST00000418609ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-3CDSENST00000498125ENST00000379454SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-3CDSENST00000498125ENST00000541428SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000418609ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000356457SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000379449SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000389204SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000445642SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000517661SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000517847SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000517856SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000517903SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000518068SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000522603SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000522835SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000522919SORBS2chr4

186599576

-ASPHchr8

62489417

-
intron-intronENST00000498125ENST00000523897SORBS2chr4

186599576

-ASPHchr8

62489417

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393528SORBS2chr4186599576-ENST00000541428ASPHchr862489417-48488316752045456
ENST00000393528SORBS2chr4186599576-ENST00000379454ASPHchr862489417-41768316752045456

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393528ENST00000541428SORBS2chr4186599576-ASPHchr862489417-0.0002900040.99971
ENST00000393528ENST00000379454SORBS2chr4186599576-ASPHchr862489417-0.0005886770.99941134

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Fusion Genomic Features for SORBS2-ASPH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SORBS2-ASPH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:186599576/chr8:62489417)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASPH

Q6ICH7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May function as 2-oxoglutarate-dependent dioxygenase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASPHchr4:186599576chr8:62489417ENST0000035645701490_1020314.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST000003794490590_1020204.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST000003892040690_1020226.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST0000044564201690_1020651.6666666666666Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST0000051784701590_1020300.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST0000051790301590_1020299.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST0000051806801390_1020271.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST000005226030590_1020211.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST0000052283501490_1020257.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST00000356457014111_3120314.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000356457014323_3320314.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST000003564570149_290314.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST0000037944905111_3120204.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST0000037944905323_3320204.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST00000379449059_290204.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST0000038920406111_3120226.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST0000038920406323_3320226.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST00000389204069_290226.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000445642016111_3120651.6666666666666Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000445642016323_3320651.6666666666666Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST000004456420169_290651.6666666666666Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000517847015111_3120300.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000517847015323_3320300.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST000005178470159_290300.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000517903015111_3120299.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000517903015323_3320299.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST000005179030159_290299.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000518068013111_3120271.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000518068013323_3320271.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST000005180680139_290271.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST0000052260305111_3120211.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST0000052260305323_3320211.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST00000522603059_290211.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000522835014111_3120257.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST00000522835014323_3320257.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST000005228350149_290257.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST000005414281425323_332325730.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST00000356457014688_6900314.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST0000037944905688_6900204.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST000003794541425688_690354759.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST0000038920406688_6900226.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST00000445642016688_6900651.6666666666666Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST00000517847015688_6900300.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST00000517903015688_6900299.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST00000518068013688_6900271.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST0000052260305688_6900211.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST00000522835014688_6900257.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST000005414281425688_690325730.0Region2-oxoglutarate binding
TgeneASPHchr4:186599576chr8:62489417ENST00000356457014341_3740314.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST00000356457014454_4870314.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST00000356457014489_5210314.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST00000356457014525_5570314.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST0000037944905341_3740204.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST0000037944905454_4870204.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST0000037944905489_5210204.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST0000037944905525_5570204.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST000003794541425454_487354759.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST000003794541425489_521354759.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST000003794541425525_557354759.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST0000038920406341_3740226.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST0000038920406454_4870226.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST0000038920406489_5210226.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST0000038920406525_5570226.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST00000445642016341_3740651.6666666666666RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST00000445642016454_4870651.6666666666666RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST00000445642016489_5210651.6666666666666RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST00000445642016525_5570651.6666666666666RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST00000517847015341_3740300.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST00000517847015454_4870300.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST00000517847015489_5210300.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST00000517847015525_5570300.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST00000517903015341_3740299.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST00000517903015454_4870299.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST00000517903015489_5210299.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST00000517903015525_5570299.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST00000518068013341_3740271.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST00000518068013454_4870271.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST00000518068013489_5210271.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST00000518068013525_5570271.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST0000052260305341_3740211.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST0000052260305454_4870211.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST0000052260305489_5210211.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST0000052260305525_5570211.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST00000522835014341_3740257.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST00000522835014454_4870257.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST00000522835014489_5210257.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST00000522835014525_5570257.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST000005414281425341_374325730.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST000005414281425454_487325730.0RepeatNote=TPR 2
TgeneASPHchr4:186599576chr8:62489417ENST000005414281425489_521325730.0RepeatNote=TPR 3
TgeneASPHchr4:186599576chr8:62489417ENST000005414281425525_557325730.0RepeatNote=TPR 4
TgeneASPHchr4:186599576chr8:62489417ENST000003564570141_530314.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST0000035645701475_7580314.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST00000379449051_530204.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST000003794490575_7580204.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST00000389204061_530226.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST000003892040675_7580226.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST000004456420161_530651.6666666666666Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST0000044564201675_7580651.6666666666666Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST000005178470151_530300.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST0000051784701575_7580300.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST000005179030151_530299.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST0000051790301575_7580299.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST000005180680131_530271.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST0000051806801375_7580271.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST00000522603051_530211.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST000005226030575_7580211.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST000005228350141_530257.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST0000052283501475_7580257.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST0000035645701454_740314.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST000003794490554_740204.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST000003892040654_740226.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST0000044564201654_740651.6666666666666TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST0000051784701554_740300.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST0000051790301554_740299.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST0000051806801354_740271.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST000005226030554_740211.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST0000052283501454_740257.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORBS2chr4:186599576chr8:62489417ENST00000284776-421167_18201101.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000284776-421640_65201101.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000284776-421931_93401101.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000319471-523167_18271732.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000319471-523640_65271732.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000319471-523931_93471732.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000355634-724167_182851201.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000355634-724640_652851201.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000355634-724931_934851201.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000393528-523167_18231667.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000393528-523640_65231667.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000393528-523931_93431667.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000418609-115167_18201005.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000418609-115640_65201005.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000418609-115931_93401005.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000431808-522167_18201101.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000431808-522640_65201101.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000431808-522931_93401101.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000437304-423167_1820825.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000437304-423640_6520825.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000437304-423931_9340825.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000448662-421167_18254662.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000448662-421640_65254662.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000448662-421931_93454662.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000449407-621167_18271645.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000449407-621640_65271645.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186599576chr8:62489417ENST00000449407-621931_93471645.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186599576chr8:62489417ENST00000284776-4211041_110001101.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000284776-42166_12701101.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000284776-421863_92201101.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000284776-421938_99901101.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000319471-5231041_110071732.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000319471-52366_12771732.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000319471-523863_92271732.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000319471-523938_99971732.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000355634-7241041_1100851201.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000355634-72466_127851201.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000355634-724863_922851201.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000355634-724938_999851201.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000393528-5231041_110031667.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000393528-52366_12731667.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000393528-523863_92231667.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000393528-523938_99931667.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000418609-1151041_110001005.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000418609-11566_12701005.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000418609-115863_92201005.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000418609-115938_99901005.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000431808-5221041_110001101.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000431808-52266_12701101.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000431808-522863_92201101.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000431808-522938_99901101.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000437304-4231041_11000825.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000437304-42366_1270825.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000437304-423863_9220825.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000437304-423938_9990825.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000448662-4211041_110054662.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000448662-42166_12754662.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000448662-421863_92254662.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000448662-421938_99954662.0DomainSH3 2
HgeneSORBS2chr4:186599576chr8:62489417ENST00000449407-6211041_110071645.0DomainSH3 3
HgeneSORBS2chr4:186599576chr8:62489417ENST00000449407-62166_12771645.0DomainSoHo
HgeneSORBS2chr4:186599576chr8:62489417ENST00000449407-621863_92271645.0DomainSH3 1
HgeneSORBS2chr4:186599576chr8:62489417ENST00000449407-621938_99971645.0DomainSH3 2
TgeneASPHchr4:186599576chr8:62489417ENST00000379454142590_102354759.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST00000541428142590_102325730.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr4:186599576chr8:62489417ENST000003794541425111_312354759.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST000003794541425323_332354759.0Compositional biasNote=Poly-Lys
TgeneASPHchr4:186599576chr8:62489417ENST0000037945414259_29354759.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST000005414281425111_312325730.0Compositional biasNote=Glu-rich
TgeneASPHchr4:186599576chr8:62489417ENST0000054142814259_29325730.0Compositional biasNote=Ser-rich
TgeneASPHchr4:186599576chr8:62489417ENST000003794541425341_374354759.0RepeatNote=TPR 1
TgeneASPHchr4:186599576chr8:62489417ENST0000037945414251_53354759.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST00000379454142575_758354759.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST0000054142814251_53325730.0Topological domainCytoplasmic
TgeneASPHchr4:186599576chr8:62489417ENST00000541428142575_758325730.0Topological domainLumenal
TgeneASPHchr4:186599576chr8:62489417ENST00000379454142554_74354759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr4:186599576chr8:62489417ENST00000541428142554_74325730.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for SORBS2-ASPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85185_85185_1_SORBS2-ASPH_SORBS2_chr4_186599576_ENST00000393528_ASPH_chr8_62489417_ENST00000379454_length(transcript)=4176nt_BP=831nt
CATTTTACTTATGGAAAACAGTGTGGCATATTCTGCTGAGCTTCGCCCTGGAAGAAGCCTCTTTTATACATCTCTTCAGGGAAGAGAGAA
GCAATGGGCATGTTAGTATACAATGATCACAGCCACGCAGGCCTGCAAGCTGCCTTTTGGACAGGCTGTTGACTGCCGTTCCAATTAGCT
GATTGGAGAATGTGGAATGCAGAGTGATAATGCTGCATATCTGCTATCAGGCAGCAGCAAAGGTTTTTGTCTTGGGAAGGCAAGCTTTCC
CTGCAATATTATCTCAGCAGCTCCCTAGCTGCTTACCCTGAAAACGAGGGATCCAAACGGAGGGTGTTGCACTCTGCTAACGCTGGTCCT
GTGCGTGGCTGTGGCATATGAGCGGCAGGTCTGAAAAAGCAGGTGTGTGCTGGGACGGGCACTGGACTGGAACGCAGGCGGACGCTCTCG
GGTTTACCTGCTTCCTGTTAACAGATTGTGGGCTCCCAGGGCATATGTCTGCACGCTGAGGCCGAGGCGGAGAAGGGGCTTCCTGAGCGT
CCCAGTACACTGACAGAGACACTTGGATTGGACTTAATCTTAAACCTCTGGAGTTCAAGACCTTTTAAAAAGGGCTAAATAAACAATCTC
TACATGTAAAAGGCCACTGACTCCTACTTCCTCTGTATAGAGCAACTGTTGAACTCAGCTGCCTGTAGGAAAACTGAAGACTTTAATAAC
AAACTCTCCAAGGTGAAAATGAACACAGGGCGTGATTCTCAGTCACCAGACTCAGCAAAAGGTTTTAGAAGCGTTCGACCAAACCTACAA
GATAAAAGATCACCAACTCAGGGAAAAATTGAGGAAGCAGTGAATGCATTTAAAGAACTAGTACGCAAATACCCTCAGAGTCCACGAGCA
AGATATGGGAAGGCGCAGTGTGAGGATGATTTGGCTGAGAAGAGGAGAAGTAATGAGGTGCTACGTGGAGCCATCGAGACCTACCAAGAG
GTGGCCAGCCTACCTGATGTCCCTGCAGACCTGCTGAAGCTGAGTTTGAAGCGTCGCTCAGACAGGCAACAATTTCTAGGTCATATGAGA
GGTTCCCTGCTTACCCTGCAGAGATTAGTTCAACTATTTCCCAATGATACTTCCTTAAAAAATGACCTTGGCGTGGGATACCTCTTGATA
GGAGATAATGACAATGCAAAGAAAGTTTATGAAGAGGTGCTGAGTGTGACACCTAATGATGGCTTTGCTAAAGTCCATTATGGCTTCATC
CTGAAGGCACAGAACAAAATTGCTGAGAGCATCCCATATTTAAAGGAAGGAATAGAATCCGGAGATCCTGGCACTGATGATGGGAGATTT
TATTTCCACCTGGGGGATGCCATGCAGAGGGTTGGGAACAAAGAGGCATATAAGTGGTATGAGCTTGGGCACAAGAGAGGACACTTTGCA
TCTGTCTGGCAACGCTCACTCTACAATGTGAATGGACTGAAAGCACAGCCTTGGTGGACCCCAAAAGAAACGGGCTACACAGAGTTAGTA
AAGTCTTTAGAAAGAAACTGGAAGTTAATCCGAGATGAAGGCCTTGCAGTGATGGATAAAGCCAAAGGTCTCTTCCTGCCTGAGGATGAA
AACCTGAGGGAAAAAGGGGACTGGAGCCAGTTCACGCTGTGGCAGCAAGGAAGAAGAAATGAAAATGCCTGCAAAGGAGCTCCTAAAACC
TGTACCTTACTAGAAAAGTTCCCCGAGACAACAGGATGCAGAAGAGGACAGATCAAATATTCCATCATGCACCCCGGGACTCACGTGTGG
CCGCACACAGGGCCCACAAACTGCAGGCTCCGAATGCACCTGGGCTTGGTGATTCCCAAGGAAGGCTGCAAGATTCGATGTGCCAACGAG
ACCAAGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATA
TTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAA
ACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAG
CCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGT
GTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCA
CATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTAT
ATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCT
AGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTAT
TTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTG
ATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAG
CATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCA
CGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAG
GGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAAT
TCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCT
TTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTA
TCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCAT
TAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCA
TGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTG
TGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTT
GACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAA
TCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTT
GTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGA
ATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAAT
TATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCC
AATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTAT

>85185_85185_1_SORBS2-ASPH_SORBS2_chr4_186599576_ENST00000393528_ASPH_chr8_62489417_ENST00000379454_length(amino acids)=456AA_BP=51
MLNSAACRKTEDFNNKLSKVKMNTGRDSQSPDSAKGFRSVRPNLQDKRSPTQGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKR
RSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLS
VTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKA
QPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRR
GQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQR

--------------------------------------------------------------
>85185_85185_2_SORBS2-ASPH_SORBS2_chr4_186599576_ENST00000393528_ASPH_chr8_62489417_ENST00000541428_length(transcript)=4848nt_BP=831nt
CATTTTACTTATGGAAAACAGTGTGGCATATTCTGCTGAGCTTCGCCCTGGAAGAAGCCTCTTTTATACATCTCTTCAGGGAAGAGAGAA
GCAATGGGCATGTTAGTATACAATGATCACAGCCACGCAGGCCTGCAAGCTGCCTTTTGGACAGGCTGTTGACTGCCGTTCCAATTAGCT
GATTGGAGAATGTGGAATGCAGAGTGATAATGCTGCATATCTGCTATCAGGCAGCAGCAAAGGTTTTTGTCTTGGGAAGGCAAGCTTTCC
CTGCAATATTATCTCAGCAGCTCCCTAGCTGCTTACCCTGAAAACGAGGGATCCAAACGGAGGGTGTTGCACTCTGCTAACGCTGGTCCT
GTGCGTGGCTGTGGCATATGAGCGGCAGGTCTGAAAAAGCAGGTGTGTGCTGGGACGGGCACTGGACTGGAACGCAGGCGGACGCTCTCG
GGTTTACCTGCTTCCTGTTAACAGATTGTGGGCTCCCAGGGCATATGTCTGCACGCTGAGGCCGAGGCGGAGAAGGGGCTTCCTGAGCGT
CCCAGTACACTGACAGAGACACTTGGATTGGACTTAATCTTAAACCTCTGGAGTTCAAGACCTTTTAAAAAGGGCTAAATAAACAATCTC
TACATGTAAAAGGCCACTGACTCCTACTTCCTCTGTATAGAGCAACTGTTGAACTCAGCTGCCTGTAGGAAAACTGAAGACTTTAATAAC
AAACTCTCCAAGGTGAAAATGAACACAGGGCGTGATTCTCAGTCACCAGACTCAGCAAAAGGTTTTAGAAGCGTTCGACCAAACCTACAA
GATAAAAGATCACCAACTCAGGGAAAAATTGAGGAAGCAGTGAATGCATTTAAAGAACTAGTACGCAAATACCCTCAGAGTCCACGAGCA
AGATATGGGAAGGCGCAGTGTGAGGATGATTTGGCTGAGAAGAGGAGAAGTAATGAGGTGCTACGTGGAGCCATCGAGACCTACCAAGAG
GTGGCCAGCCTACCTGATGTCCCTGCAGACCTGCTGAAGCTGAGTTTGAAGCGTCGCTCAGACAGGCAACAATTTCTAGGTCATATGAGA
GGTTCCCTGCTTACCCTGCAGAGATTAGTTCAACTATTTCCCAATGATACTTCCTTAAAAAATGACCTTGGCGTGGGATACCTCTTGATA
GGAGATAATGACAATGCAAAGAAAGTTTATGAAGAGGTGCTGAGTGTGACACCTAATGATGGCTTTGCTAAAGTCCATTATGGCTTCATC
CTGAAGGCACAGAACAAAATTGCTGAGAGCATCCCATATTTAAAGGAAGGAATAGAATCCGGAGATCCTGGCACTGATGATGGGAGATTT
TATTTCCACCTGGGGGATGCCATGCAGAGGGTTGGGAACAAAGAGGCATATAAGTGGTATGAGCTTGGGCACAAGAGAGGACACTTTGCA
TCTGTCTGGCAACGCTCACTCTACAATGTGAATGGACTGAAAGCACAGCCTTGGTGGACCCCAAAAGAAACGGGCTACACAGAGTTAGTA
AAGTCTTTAGAAAGAAACTGGAAGTTAATCCGAGATGAAGGCCTTGCAGTGATGGATAAAGCCAAAGGTCTCTTCCTGCCTGAGGATGAA
AACCTGAGGGAAAAAGGGGACTGGAGCCAGTTCACGCTGTGGCAGCAAGGAAGAAGAAATGAAAATGCCTGCAAAGGAGCTCCTAAAACC
TGTACCTTACTAGAAAAGTTCCCCGAGACAACAGGATGCAGAAGAGGACAGATCAAATATTCCATCATGCACCCCGGGACTCACGTGTGG
CCGCACACAGGGCCCACAAACTGCAGGCTCCGAATGCACCTGGGCTTGGTGATTCCCAAGGAAGGCTGCAAGATTCGATGTGCCAACGAG
ACCAAGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATA
TTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAA
ACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAG
CCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGT
GTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCA
CATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTAT
ATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCT
AGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTAT
TTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTG
ATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAG
CATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCA
CGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAG
GGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAAT
TCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCT
TTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTA
TCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCAT
TAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCA
TGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTG
TGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTT
GACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAA
TCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTT
GTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGA
ATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAAT
TATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCC
AATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTAT
TTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGT
TTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATT
GTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCT
CTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGG
GTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCAT
ATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGC
TGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTAT

>85185_85185_2_SORBS2-ASPH_SORBS2_chr4_186599576_ENST00000393528_ASPH_chr8_62489417_ENST00000541428_length(amino acids)=456AA_BP=51
MLNSAACRKTEDFNNKLSKVKMNTGRDSQSPDSAKGFRSVRPNLQDKRSPTQGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKR
RSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLS
VTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKA
QPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRR
GQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SORBS2-ASPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SORBS2-ASPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SORBS2-ASPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource