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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SORBS2-MRPS35 (FusionGDB2 ID:85191)

Fusion Gene Summary for SORBS2-MRPS35

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2-MRPS35
Fusion gene ID: 85191
HgeneTgene
Gene symbol

SORBS2

MRPS35

Gene ID

8470

60488

Gene namesorbin and SH3 domain containing 2mitochondrial ribosomal protein S35
SynonymsARGBP2|PRO0618HDCMD11P|MDS023|MRP-S28|MRPS28
Cytomap

4q35.1

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 228S ribosomal protein S35, mitochondrial28S ribosomal protein S28, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35
Modification date2020031320200313
UniProtAcc.

P82673

Ensembl transtripts involved in fusion geneENST00000284776, ENST00000319471, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000431808, 
ENST00000437304, ENST00000448662, 
ENST00000449407, ENST00000498125, 
ENST00000538315, ENST00000081029, 
Fusion gene scores* DoF score16 X 20 X 8=256015 X 8 X 7=840
# samples 2120
** MAII scorelog2(21/2560*10)=-3.60768257722124
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/840*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORBS2 [Title/Abstract] AND MRPS35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSORBS2(186570621)-MRPS35(27908114), # samples:3
Anticipated loss of major functional domain due to fusion event.SORBS2-MRPS35 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SORBS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPS35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-4L-AA1F-01ASORBS2chr4

186570621

-MRPS35chr12

27908114

+
ChimerDB4PRADTCGA-4L-AA1FSORBS2chr4

186568286

-MRPS35chr12

27908114

+
ChimerDB4PRADTCGA-4L-AA1FSORBS2chr4

186570621

-MRPS35chr12

27908114

+


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Fusion Gene ORF analysis for SORBS2-MRPS35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000284776ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000319471ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000355634ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000393528ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000418609ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000431808ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000437304ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000448662ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5CDS-3UTRENST00000449407ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5UTR-3CDSENST00000498125ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
5UTR-3UTRENST00000498125ENST00000538315SORBS2chr4

186570621

-MRPS35chr12

27908114

+
Frame-shiftENST00000284776ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
Frame-shiftENST00000319471ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
Frame-shiftENST00000355634ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
Frame-shiftENST00000393528ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
Frame-shiftENST00000418609ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
Frame-shiftENST00000431808ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
In-frameENST00000437304ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
In-frameENST00000448662ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
In-frameENST00000449407ENST00000081029SORBS2chr4

186570621

-MRPS35chr12

27908114

+
intron-3CDSENST00000284776ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000319471ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000355634ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000393528ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000418609ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000431808ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000437304ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000448662ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000449407ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3CDSENST00000498125ENST00000081029SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000284776ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000319471ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000355634ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000393528ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000418609ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000431808ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000437304ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000448662ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000449407ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+
intron-3UTRENST00000498125ENST00000538315SORBS2chr4

186568286

-MRPS35chr12

27908114

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448662SORBS2chr4186570621-ENST00000081029MRPS35chr1227908114+20789631871068293
ENST00000437304SORBS2chr4186570621-ENST00000081029MRPS35chr1227908114+280516903411795484
ENST00000449407SORBS2chr4186570621-ENST00000081029MRPS35chr1227908114+269015757931680295

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448662ENST00000081029SORBS2chr4186570621-MRPS35chr1227908114+0.0009690270.99903095
ENST00000437304ENST00000081029SORBS2chr4186570621-MRPS35chr1227908114+0.0026107210.99738926
ENST00000449407ENST00000081029SORBS2chr4186570621-MRPS35chr1227908114+0.0012723050.99872774

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Fusion Genomic Features for SORBS2-MRPS35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SORBS2chr4186570620-MRPS35chr1227908113+5.96E-070.9999994
SORBS2chr4186570620-MRPS35chr1227908113+5.96E-070.9999994
SORBS2chr4186570620-MRPS35chr1227908113+5.96E-070.9999994
SORBS2chr4186570620-MRPS35chr1227908113+5.96E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SORBS2-MRPS35


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:186570621/chr12:27908114)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MRPS35

P82673

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORBS2chr4:186570621chr12:27908114ENST00000284776-921167_1821891101.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000319471-1023167_182275732.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000355634-1224167_1822891201.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000393528-1023167_182235667.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000431808-1022167_1821891101.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000437304-1023167_182368825.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000448662-921167_182258662.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000449407-1021167_182260645.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000284776-92166_1271891101.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000319471-102366_127275732.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000355634-122466_1272891201.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000393528-102366_127235667.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000431808-102266_1271891101.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000437304-102366_127368825.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000448662-92166_127258662.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000449407-102166_127260645.0DomainSoHo
TgeneMRPS35chr4:186570621chr12:27908114ENST0000008102968257_321234324.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr4:186570621chr12:27908114ENST0000053831557257_321197526.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORBS2chr4:186570621chr12:27908114ENST00000284776-921640_6521891101.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000284776-921931_9341891101.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000319471-1023640_652275732.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000319471-1023931_934275732.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000355634-1224640_6522891201.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000355634-1224931_9342891201.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000393528-1023640_652235667.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000393528-1023931_934235667.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000418609-315167_182931005.0Compositional biasNote=Pro-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000418609-315640_652931005.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000418609-315931_934931005.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000431808-1022640_6521891101.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000431808-1022931_9341891101.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000437304-1023640_652368825.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000437304-1023931_934368825.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000448662-921640_652258662.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000448662-921931_934258662.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000449407-1021640_652260645.0Compositional biasNote=His-rich
HgeneSORBS2chr4:186570621chr12:27908114ENST00000449407-1021931_934260645.0Compositional biasNote=Poly-Pro
HgeneSORBS2chr4:186570621chr12:27908114ENST00000284776-9211041_11001891101.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000284776-921863_9221891101.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000284776-921938_9991891101.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000319471-10231041_1100275732.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000319471-1023863_922275732.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000319471-1023938_999275732.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000355634-12241041_11002891201.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000355634-1224863_9222891201.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000355634-1224938_9992891201.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000393528-10231041_1100235667.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000393528-1023863_922235667.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000393528-1023938_999235667.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000418609-3151041_1100931005.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000418609-31566_127931005.0DomainSoHo
HgeneSORBS2chr4:186570621chr12:27908114ENST00000418609-315863_922931005.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000418609-315938_999931005.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000431808-10221041_11001891101.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000431808-1022863_9221891101.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000431808-1022938_9991891101.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000437304-10231041_1100368825.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000437304-1023863_922368825.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000437304-1023938_999368825.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000448662-9211041_1100258662.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000448662-921863_922258662.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000448662-921938_999258662.0DomainSH3 2
HgeneSORBS2chr4:186570621chr12:27908114ENST00000449407-10211041_1100260645.0DomainSH3 3
HgeneSORBS2chr4:186570621chr12:27908114ENST00000449407-1021863_922260645.0DomainSH3 1
HgeneSORBS2chr4:186570621chr12:27908114ENST00000449407-1021938_999260645.0DomainSH3 2


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Fusion Gene Sequence for SORBS2-MRPS35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85191_85191_1_SORBS2-MRPS35_SORBS2_chr4_186570621_ENST00000437304_MRPS35_chr12_27908114_ENST00000081029_length(transcript)=2805nt_BP=1690nt
AGCTTTCAAAAATAGCATAGTTGATGAAACTGGAAATTTAGGTGCGGGCTCTTTTAAGAAATCATTTGTCTTCAGTCTTAAGAATAGACT
GACAACAGATACTGCTACCAGAGGGCTCTCAACTATTTCTTAAGACCCCCTAGGAAATATCAGAAGAAAAGCCTCCTTCTCAATAAAGCA
TAAGTAGGACATCTCGTTTTCAGTGAATCAGACACTTGGATTGGACTTAATCTTAAACCTCTGGAGTTCAAGACCTTTTAAAAAGGGCTA
AATAAACAATCTCTACATGTAAAAGGCCACTGACTCCTACTTCCTCTGTATAGAGCAACTGTTGAACTCAGCTGCCTGTAGGGCGTGATT
CTCAGTCACCAGACTCAGCAAAAGGTTTTAGAAGCGTTCGACCAAACCTACAAGATAAAAGATCACCAACTCAGGCACCCCCTCCACCAG
AAAGAAAAGAGAGCTTTCATAGCTCTTTGATAACCAGTCACACAAAGGGTGTCATTTTAGACCAGTTAGTAACTAACACACAAATTCCCT
CCAGTACAGAGTACTTTGCTAACAAAAAACCTCTTCAGGGAACTATGTATTCCAATGAAGATTCGAGACAGACAATTGTATATTCTGAAG
AATCTAACACAACCATGTCATATACACAAAAAATCACTAATCCACTACCAGCAGCTTCCAGCACGGATCCTGCACCATTCGCTAACATCA
ACACCCCAGTTCTACAAGAGGACTACAGGCAAGATTCTCAAACTCGGAGGATTTCTACCTTGAAACTAACCCATAACCAGGATCTAGGAA
GTAGCAGCCCCATTAGTACTCCACAGTTCTCCAAATCTGTCGAAGTACCGTCATTTCTCAAAAGGCCCCGCTCACTGACCCCTAATCCAG
TGCCTGAGACACACACAGCATCTCTTTCCATTCAGATAGCTCCCCTTTCAGGACAGGATCTTGAAAGCCACAAACAGCTACCTGAGCTTT
CTCCAGAGACTGCAAAGATACCTCTTCAGCAAGAGAGACAAAAATCTGCAGTTGCAGCGGCCTCTCAGTCCTCAGACTGCAGAGTGAGCC
AGATAACAGTGAATGGAAACTCAGGAGGTGCCGTGAGTCCCATGAGTTACTATCAGAGGCCGTTTTCCCCCTCGGCATATTCTCTCCCAG
CCTCACTCAACTCCAGCATTGTCATGCAGCACGGCACATCCCTCGATTCCACAGACACATATCCCCAGCATGCGCAGTCTCTGGATGGCA
CCACCAGCAGCTCTATCCCCCTGTACCGATCCTCAGAGGAAGAGAAGAGAGTGACAGTCATCAAAGCCCCGCATTACCCAGGGATCGGGC
CCGTGGATGAATCCGGAATCCCCACAGCAATTAGAACGACAGTCGACCGGCCCAAGGACTGGTACAAGACGATGTTTAAGCAAATTCACA
TGGTGCACAAGCCGGATGATGACACAGACATGTATAATACTCCTTATACATACAATGCAGGTCTGTACAACCCACCCTACAGTGCTCAGT
CACACCCTGCTGCAAAGACCCAAACCTACAGACCTCTTTCCAAAAGCCACTCCGACAACAGCCCCAATGCCTTTAAGGATGCGTCCTCCC
CAGTGCCTCCCCCACATGTTCCACCTCCAGTCCCGCCGCTTCGACCAAGAGATCGGTCTTCAACAGAAAAAATACTGAAGAATGGGAAAA
AAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGC
TGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAA
TGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCT
GCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAG
TTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTC
TCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTT
TATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAG
AACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGA
AACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTG
GGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCC
ACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCA
ATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATTAATTTAAAATCAAAATAAAG

>85191_85191_1_SORBS2-MRPS35_SORBS2_chr4_186570621_ENST00000437304_MRPS35_chr12_27908114_ENST00000081029_length(amino acids)=484AA_BP=450
MPVGRDSQSPDSAKGFRSVRPNLQDKRSPTQAPPPPERKESFHSSLITSHTKGVILDQLVTNTQIPSSTEYFANKKPLQGTMYSNEDSRQ
TIVYSEESNTTMSYTQKITNPLPAASSTDPAPFANINTPVLQEDYRQDSQTRRISTLKLTHNQDLGSSSPISTPQFSKSVEVPSFLKRPR
SLTPNPVPETHTASLSIQIAPLSGQDLESHKQLPELSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPMSYYQRPFSP
SAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKT
MFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEK

--------------------------------------------------------------
>85191_85191_2_SORBS2-MRPS35_SORBS2_chr4_186570621_ENST00000448662_MRPS35_chr12_27908114_ENST00000081029_length(transcript)=2078nt_BP=963nt
AAGCAGATAGGTTTCAGAGATAAAGAGTGAAACCAAAAACACCGCACACCTCATCCAAATCTGCGCTCATACTTGCAGCAAATGTTTGCT
GTCAGTTGCTTCATAATAACAGCACAGACCCCGAATTGCAGGAGGAATTGCCTGGTAGAAAACTGAAGACTTTAATAACAAACTCTCCAA
GGTGAAAATGAACACAGGGCGTGATTCTCAGTCACCAGACTCAGCTTGGAGATCTTACAATGATGGCAATCAGGAGACACTGAACGGAGA
TGCTACATATTCCTCTCTTGCAGCAAAAGGTTTTAGAAGCGTTCGACCAAACCTACAAGATAAAAGATCACCAACTCAGAGCCAGATAAC
AGTGAATGGAAACTCAGGAGGTGCCGTGAGTCCCATGAGTTACTATCAGAGGCCGTTTTCCCCCTCGGCATATTCTCTCCCAGCCTCACT
CAACTCCAGCATTGTCATGCAGCACGGCACATCCCTCGATTCCACAGACACATATCCCCAGCATGCGCAGTCTCTGGATGGCACCACCAG
CAGCTCTATCCCCCTGTACCGATCCTCAGAGGAAGAGAAGAGAGTGACAGTCATCAAAGCCCCGCATTACCCAGGGATCGGGCCCGTGGA
TGAATCCGGAATCCCCACAGCAATTAGAACGACAGTCGACCGGCCCAAGGACTGGTACAAGACGATGTTTAAGCAAATTCACATGGTGCA
CAAGCCGGATGATGACACAGACATGTATAATACTCCTTATACATACAATGCAGGTCTGTACAACCCACCCTACAGTGCTCAGTCACACCC
TGCTGCAAAGACCCAAACCTACAGACCTCTTTCCAAAAGCCACTCCGACAACAGCCCCAATGCCTTTAAGGATGCGTCCTCCCCAGTGCC
TCCCCCACATGTTCCACCTCCAGTCCCGCCGCTTCGACCAAGAGATCGGTCTTCAACAGAAAAAATACTGAAGAATGGGAAAAAAGTAAG
ACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAG
AAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAG
GAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGAT
TTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAAT
TATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATT
TCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACC
TTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCAT
TTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGT
CCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCA
TTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTC
AGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGC
TGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATTAATTTAAAATCAAAATAAAGGAATTAC

>85191_85191_2_SORBS2-MRPS35_SORBS2_chr4_186570621_ENST00000448662_MRPS35_chr12_27908114_ENST00000081029_length(amino acids)=293AA_BP=259
MNTGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNS
SIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP
DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKILKNGKKVRLK

--------------------------------------------------------------
>85191_85191_3_SORBS2-MRPS35_SORBS2_chr4_186570621_ENST00000449407_MRPS35_chr12_27908114_ENST00000081029_length(transcript)=2690nt_BP=1575nt
GAGCTGAGAGGACCAGCCATTTTACTTATGGAAAACAGTGTGGCATATTCTGCTGAGCTTCGCCCTGGAAGAAGCCTCTTTTATACATCT
CTTCAGGGAAGAGAGAAGCAATGGGCATGTTAGTATACAATGATCACAGCCACGCAGGCCTGCAAGCTGCCTTTTGGACAGGCTGTTGAC
TGCCGTTCCAATTAGCTGATTGGAGAATGTGGAATGCAGAGTGATAATGCTGCATATCTGCTATCAGGCAGCAGCAAAGGTTTTTGTCTT
GGGAAGGCAAGCTTTCCCTGCAATATTATCTCAGCAGCTCCCTAGCTGCTTACCCTGAAAACGAGGGATCCAAACGGAGGGTGTTGCACT
CTGCTAACGCTGGTCCTGTGCGTGGCTGTGGCATATGAGCGGCAGGTCTGAAAAAGCAGGTGTGTGCTGGGACGGGCACTGGACTGGAAC
GCAGGCGGACGCTCTCGGGTTTACCTGCTTCCTGTTAACAGATTGTGGGCTCCCAGGGCATATGTCTGCACGCTGAGGCCGAGGCGGAGA
AGGGGCTTCCTGAGCGTCCCAGTACACTGACAGAGACACTTGGATTGGACTTAATCTTAAACCTCTGGAGTTCAAGACCTTTTAAAAAGG
GCTAAATAAACAATCTCTACATGTAAAAGGCCACTGACTCCTACTTCCTCTGTATAGAGCAACTGTTGAACTCAGCTGCCTGTAGGAAAA
CTGAAGACTTTAATAACAAACTCTCCAAGGTGAAAATGAACACAGCGGTGGGTGTGCTCGCAAACGTGCCGCCATGTCTGTTACGCTAAC
ATCTGTGAAGAGAGTGCAAAGTTCTCCAAACCTATTGGCTGCAGGGCGTGATTCTCAGTCACCAGACTCAGCTTGGAGATCTTACAATGA
TGGCAATCAGGAGACACTGAACGGAGATGCTACATATTCCTCTCTTGCAGCAAAAGGTTTTAGAAGCGTTCGACCAAACCTACAAGATAA
AAGATCACCAACTCAGAGCCAGATAACAGTGAATGGAAACTCAGGAGGTGCCGTGAGTCCCATGAGTTACTATCAGAGGCCGTTTTCCCC
CTCGGCATATTCTCTCCCAGCCTCACTCAACTCCAGCATTGTCATGCAGCACGGCACATCCCTCGATTCCACAGACACATATCCCCAGCA
TGCGCAGTCTCTGGATGGCACCACCAGCAGCTCTATCCCCCTGTACCGATCCTCAGAGGAAGAGAAGAGAGTGACAGTCATCAAAGCCCC
GCATTACCCAGGGATCGGGCCCGTGGATGAATCCGGAATCCCCACAGCAATTAGAACGACAGTCGACCGGCCCAAGGACTGGTACAAGAC
GATGTTTAAGCAAATTCACATGGTGCACAAGCCGGGTCTGTACAACCCACCCTACAGTGCTCAGTCACACCCTGCTGCAAAGACCCAAAC
CTACAGACCTCTTTCCAAAAGCCACTCCGACAACAGCCCCAATGCCTTTAAGGATGCGTCCTCCCCAGTGCCTCCCCCACATGTTCCACC
TCCAGTCCCGCCGCTTCGACCAAGAGATCGGTCTTCAACAGAAAAAATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAA
GAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAAT
AAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATT
TCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATAT
ATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAAT
GCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTG
TTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCC
ACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTC
CGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTA
ACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCT
ACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCAT
AACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTT

>85191_85191_3_SORBS2-MRPS35_SORBS2_chr4_186570621_ENST00000449407_MRPS35_chr12_27908114_ENST00000081029_length(amino acids)=295AA_BP=261
MSVTLTSVKRVQSSPNLLAAGRDSQSPDSAWRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYY
QRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP
KDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKILKNGKKVR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SORBS2-MRPS35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SORBS2-MRPS35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SORBS2-MRPS35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource