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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SORL1-SYTL2 (FusionGDB2 ID:85247)

Fusion Gene Summary for SORL1-SYTL2

check button Fusion gene summary
Fusion gene informationFusion gene name: SORL1-SYTL2
Fusion gene ID: 85247
HgeneTgene
Gene symbol

SORL1

SYTL2

Gene ID

6653

54843

Gene namesortilin related receptor 1synaptotagmin like 2
SynonymsC11orf32|LR11|LRP9|SORLA|SorLA-1|gp250CHR11SYT|EXO4|PPP1R151|SGA72M|SLP2|SLP2A
Cytomap

11q24.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionsortilin-related receptorLDLR relative with 11 ligand-binding repeatslow-density lipoprotein receptor relative with 11 ligand-binding repeatsmosaic protein LR11sortilin-related receptor, L(DLR class) A repeats containingsorting protein-related receptsynaptotagmin-like protein 2breast cancer-associated antigen SGA-72Mchromosome 11 synaptotagminexophilin-4protein phosphatase 1, regulatory subunit 151
Modification date2020032720200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000260197, ENST00000525532, 
ENST00000527934, ENST00000532694, 
ENST00000534286, ENST00000532451, 
ENST00000529581, ENST00000533892, 
ENST00000316356, ENST00000354566, 
ENST00000359152, ENST00000389958, 
ENST00000524452, ENST00000525423, 
ENST00000525702, ENST00000527523, 
ENST00000528231, ENST00000528566, 
ENST00000389960, 
Fusion gene scores* DoF score17 X 17 X 8=231215 X 13 X 9=1755
# samples 2318
** MAII scorelog2(23/2312*10)=-3.3294356315563
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1755*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORL1 [Title/Abstract] AND SYTL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSORL1(121466481)-SYTL2(85428573), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSORL1

GO:0006605

protein targeting

16407538|21385844|27322061

HgeneSORL1

GO:0006622

protein targeting to lysosome

24523320

HgeneSORL1

GO:0006892

post-Golgi vesicle-mediated transport

17855360

HgeneSORL1

GO:0014910

regulation of smooth muscle cell migration

14764453

HgeneSORL1

GO:0032091

negative regulation of protein binding

16407538

HgeneSORL1

GO:0034067

protein localization to Golgi apparatus

17855360

HgeneSORL1

GO:0038020

insulin receptor recycling

27322061

HgeneSORL1

GO:0045053

protein retention in Golgi apparatus

17855360

HgeneSORL1

GO:0045732

positive regulation of protein catabolic process

24523320

HgeneSORL1

GO:0046628

positive regulation of insulin receptor signaling pathway

27322061

HgeneSORL1

GO:0051604

protein maturation

17855360

HgeneSORL1

GO:1900168

positive regulation of glial cell-derived neurotrophic factor secretion

21994944

HgeneSORL1

GO:1902430

negative regulation of amyloid-beta formation

16407538|22621900

HgeneSORL1

GO:1902960

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

16407538

HgeneSORL1

GO:1904179

positive regulation of adipose tissue development

27322061

TgeneSYTL2

GO:0006887

exocytosis

18812475

TgeneSYTL2

GO:0006904

vesicle docking involved in exocytosis

18812475

TgeneSYTL2

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across SORL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SYTL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4632-01ASORL1chr11

121466481

-SYTL2chr11

85428573

-
ChimerDB4LUADTCGA-38-4632-01ASORL1chr11

121466481

+SYTL2chr11

85428573

-


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Fusion Gene ORF analysis for SORL1-SYTL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000260197ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000260197ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000525532ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000525532ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000527934ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000527934ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000532694ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000532694ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000534286ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000534286ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000260197ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000525532ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000527934ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000532694ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000534286ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-3CDSENST00000532451ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-5UTRENST00000532451ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-5UTRENST00000532451ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260197SORL1chr11121466481+ENST00000389960SYTL2chr1185428573-673746486657651899
ENST00000525532SORL1chr11121466481+ENST00000389960SYTL2chr1185428573-36781589942706870
ENST00000532694SORL1chr11121466481+ENST00000389960SYTL2chr1185428573-352714383812555724
ENST00000534286SORL1chr11121466481+ENST00000389960SYTL2chr1185428573-33491260112377788
ENST00000527934SORL1chr11121466481+ENST00000389960SYTL2chr1185428573-28747854211902493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260197ENST00000389960SORL1chr11121466481+SYTL2chr1185428573-0.0002281470.9997719
ENST00000525532ENST00000389960SORL1chr11121466481+SYTL2chr1185428573-0.0002788130.9997211
ENST00000532694ENST00000389960SORL1chr11121466481+SYTL2chr1185428573-0.0004048430.9995952
ENST00000534286ENST00000389960SORL1chr11121466481+SYTL2chr1185428573-0.0005442610.99945575
ENST00000527934ENST00000389960SORL1chr11121466481+SYTL2chr1185428573-0.0003737220.9996263

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Fusion Genomic Features for SORL1-SYTL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SORL1-SYTL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:121466481/chr11:85428573)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481026_107215062215.0DomainNote=EGF-like
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481076_111415062215.0DomainLDL-receptor class A 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481115_115515062215.0DomainLDL-receptor class A 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481156_119415062215.0DomainLDL-receptor class A 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481198_123615062215.0DomainLDL-receptor class A 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481238_127215062215.0DomainLDL-receptor class A 5
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481273_131715062215.0DomainLDL-receptor class A 6
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481323_136115062215.0DomainLDL-receptor class A 7
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481366_140515062215.0DomainLDL-receptor class A 8
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481417_145515062215.0DomainLDL-receptor class A 9
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481469_150815062215.0DomainLDL-receptor class A 10
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+324863_6515062215.0MotifCell attachment site
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248136_14715062215.0RepeatNote=BNR 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248232_24315062215.0RepeatNote=BNR 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248441_45215062215.0RepeatNote=BNR 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248521_53215062215.0RepeatNote=BNR 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248562_57315062215.0RepeatNote=BNR 5
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248800_84315062215.0RepeatNote=LDL-receptor class B 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248844_88715062215.0RepeatNote=LDL-receptor class B 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248888_93215062215.0RepeatNote=LDL-receptor class B 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248933_97015062215.0RepeatNote=LDL-receptor class B 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248971_101315062215.0RepeatNote=LDL-receptor class B 5
TgeneSYTL2chr11:121466481chr11:85428573ENST00000316356019579_6190936.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST0000038995809579_6190366.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389960919579_619538911.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000524452818579_619538911.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525423012579_61901257.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST0000052570209579_6190377.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000527523819579_619490903.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000528231018579_6190935.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000529581112579_6190377.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000533892111579_6190337.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST000003163560191_570936.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000316356019628_7530936.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000316356019768_8970936.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389958091_570366.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST0000038995809628_7530366.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST0000038995809768_8970366.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389960919628_753538911.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389960919768_897538911.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000524452818628_753538911.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000524452818768_897538911.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST000005254230121_5701257.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525423012628_75301257.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525423012768_89701257.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525702091_570377.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST0000052570209628_7530377.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST0000052570209768_8970377.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000527523819628_753490903.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000527523819768_897490903.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST000005282310181_570935.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000528231018628_7530935.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000528231018768_8970935.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST000005295811121_570377.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000529581112628_7530377.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000529581112768_8970377.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST000005338921111_570337.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000533892111628_7530337.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000533892111768_8970337.0DomainC2 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481512_155115062215.0DomainLDL-receptor class A 11
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481557_164915062215.0DomainFibronectin type-III 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481653_174515062215.0DomainFibronectin type-III 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481749_184415062215.0DomainFibronectin type-III 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481843_192715062215.0DomainFibronectin type-III 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481934_202915062215.0DomainFibronectin type-III 5
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482030_211815062215.0DomainFibronectin type-III 6
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482161_216415062215.0MotifPotential nuclear localization signal for the C-terminal fragment generated by PSEN1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482159_221415062215.0Topological domainCytoplasmic
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+324882_213715062215.0Topological domainLumenal
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482138_215815062215.0TransmembraneHelical
TgeneSYTL2chr11:121466481chr11:85428573ENST00000354566213579_6198601273.0Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST000003545662131_578601273.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000354566213628_7538601273.0DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000354566213768_8978601273.0DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST000003899609191_57538911.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST000005244528181_57538911.0DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST000005275238191_57490903.0DomainRabBD


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Fusion Gene Sequence for SORL1-SYTL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85247_85247_1_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000260197_SYTL2_chr11_85428573_ENST00000389960_length(transcript)=6737nt_BP=4648nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCC
TATGACAAACCAAATACCATCTACATTGAACGACATGAACCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGG
GAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTTCAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGCATCTCTTGGGC
AGTGAACAGCAGTCTTCTGTCCAGCTCTGGGTCTCCTTTGGCCGGAAGCCCATGAGAGCAGCCCAGTTTGTCACAAGACATCCTATTAAT
GAATATTACATCGCAGATGCCTCCGAGGACCAGGTGTTTGTGTGTGTCAGCCACAGTAACAACCGCACCAATTTATACATCTCAGAGGCA
GAGGGGCTGAAGTTCTCCCTGTCCTTGGAGAACGTGCTCTATTACAGCCCAGGAGGGGCCGGCAGTGACACCTTGGTGAGGTATTTTGCA
AATGAACCATTTGCTGACTTCCACCGAGTGGAAGGATTGCAAGGAGTCTACATTGCTACTCTGATTAATGGTTCTATGAATGAGGAGAAC
ATGAGATCGGTCATCACCTTTGACAAAGGGGGAACCTGGGAGTTTCTTCAGGCTCCAGCCTTCACGGGATATGGAGAGAAAATCAATTGT
GAGCTTTCCCAGGGCTGTTCCCTTCATCTGGCTCAGCGCCTCAGTCAGCTCCTCAACCTCCAGCTCCGGAGAATGCCCATCCTGTCCAAG
GAGTCGGCTCCAGGCCTCATCATCGCCACTGGCTCAGTGGGAAAGAACTTGGCTAGCAAGACAAACGTGTACATCTCTAGCAGTGCTGGA
GCCAGGTGGCGAGAGGCACTTCCTGGACCTCACTACTACACATGGGGAGACCACGGCGGAATCATCACGGCTATTGCCCAGGGCATGGAA
ACCAACGAGCTAAAATACAGTACCAATGAAGGGGAGACCTGGAAAACATTCATCTTCTCTGAGAAGCCAGTGTTTGTGTATGGCCTCCTC
ACAGAACCTGGGGAGAAGAGCACTGTCTTCACCATCTTTGGCTCGAACAAAGAGAATGTCCACAGCTGGCTGATCCTCCAGGTCAATGCC
ACGGATGCCTTGGGAGTTCCCTGCACAGAGAATGACTACAAGCTGTGGTCACCATCTGATGAGCGGGGGAATGAGTGTTTGCTGGGACAC
AAGACTGTTTTCAAACGGCGGACCCCCCATGCCACATGCTTCAATGGAGAGGACTTTGACAGGCCGGTGGTCGTGTCCAACTGCTCCTGC
ACCCGGGAGGACTATGAGTGTGACTTCGGTTTCAAGATGAGTGAAGATTTGTCATTAGAGGTTTGTGTTCCAGATCCGGAATTTTCTGGA
AAGTCATACTCCCCTCCTGTGCCTTGCCCTGTGGGTTCTACTTACAGGAGAACGAGAGGCTACCGGAAGATTTCTGGGGACACTTGTAGC
GGAGGAGATGTTGAAGCGCGACTGGAAGGAGAGCTGGTCCCCTGTCCCCTGGCAGAAGAGAACGAGTTCATTCTGTATGCTGTGAGGAAA
TCCATCTACCGCTATGACCTGGCCTCGGGAGCCACCGAGCAGTTGCCTCTCACCGGGCTACGGGCAGCAGTGGCCCTGGACTTTGACTAT
GAGCACAACTGTTTGTATTGGTCCGACCTGGCCTTGGACGTCATCCAGCGCCTCTGTTTGAATGGAAGCACAGGGCAAGAGGTGATCATC
AATTCTGGCCTGGAGACAGTAGAAGCTTTGGCTTTTGAACCCCTCAGCCAGCTGCTTTACTGGGTAGATGCAGGCTTCAAAAAGATTGAG
GTAGCTAATCCAGATGGCGACTTCCGACTCACAATCGTCAATTCCTCTGTGCTTGATCGTCCCAGGGCTCTGGTCCTCGTGCCCCAAGAG
GGGGTGATGTTCTGGACAGACTGGGGAGACCTGAAGCCTGGGATTTATCGGAGCAATATGGATGGTTCTGCTGCCTATCACCTGGTGTCT
GAGGATGTGAAGTGGCCCAATGGCATCTCTGTGGACGACCAGTGGATTTACTGGACGGATGCCTACCTGGAGTGCATAGAGCGGATCACG
TTCAGTGGCCAGCAGCGCTCTGTCATTCTGGACAACCTCCCGCACCCCTATGCCATTGCTGTCTTTAAGAATGAAATCTACTGGGATGAC
TGGTCACAGCTCAGCATATTCCGAGCTTCCAAATACAGTGGGTCCCAGATGGAGATTCTGGCAAACCAGCTCACGGGGCTCATGGACATG
AAGATTTTCTACAAGGGGAAGAACACTGGAAGCAATGCCTGTGTGCCCAGGCCATGCAGCCTGCTGTGCCTGCCCAAGGCCAACAACAGT
AGAAGCTGCAGGTGTCCAGAGGATGTGTCCAGCAGTGTGCTTCCATCAGGGGACCTGATGTGTGACTGCCCTCAGGGCTATCAGCTCAAG
AACAATACCTGTGTCAAACAAGAGAACACCTGTCTTCGCAACCAGTATCGCTGCAGCAACGGGAACTGTATCAACAGCATTTGGTGGTGT
GACTTTGACAACGACTGTGGAGACATGAGCGATGAGAGAAACTGCCCTACCACCATCTGTGACCTGGACACCCAGTTTCGTTGCCAGGAG
TCTGGGACTTGTATCCCACTGTCCTATAAATGTGACCTTGAGGATGACTGTGGAGACAACAGTGATGAAAGTCATTGTGAAATGCACCAG
TGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGTGACGGGGACAACGACTGCAGGGACTGGTCT
GATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGAAACGGGCACTGCATCCCCCAGCGGTGGGCG
TGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAGAAGTGCAATGGATTCCGCTGCCCAAACGGC
ACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGATGAACAGCACTGCGAGCCCCTCTGTACGCAC
TTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGACGGAATCATCCAGTGCCGCGACGGGTCCGAT
GAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAGTTCGGTTTCCAGTGTCAGAATGGAGTGTGC
ATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCCAACTGCGAAAACCCCACAGAAGCCCCAAAC
TGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAATGTGACAGGGAGAACGACTGTGGGGACTGG
TCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTACCGCTGCAGC
AGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCCTTGCTTGCA
AACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGTATTCCCAAC
TGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCAGTTACAAAT
GAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTT
CCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAG
TTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAG
CGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAAT
CCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACA
TTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTAC
CCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTC
CCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAAT
TCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTC
AACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACC
AACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAA
GTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCC
AAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATC
CTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGAT
TTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCA
AAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTC
TGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGG
AATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCAT
ATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACC
CACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTT
TAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAG
TTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTAT

>85247_85247_1_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000260197_SYTL2_chr11_85428573_ENST00000389960_length(amino acids)=1899AA_BP=1528
MASRCTFSPGGGATCSSVRPNMATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGA
SRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNR
SEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVK
SFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQ
FVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLI
NGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTN
VYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHS
WLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVC
VPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRA
AVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPR
ALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVF
KNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCD
CPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSD
ESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKC
NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFG
FQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTC
LPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEK
PDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDL
AAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNK
QNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAV
GKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR

--------------------------------------------------------------
>85247_85247_2_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000525532_SYTL2_chr11_85428573_ENST00000389960_length(transcript)=3678nt_BP=1589nt
AGTCTGATCTGGCTGAAGACAGGATGCAAGTCACTGGTTATACTGAGCAGAAGTTTTCAGCACAGTAGGCGCCCCAAAGCTTGCCACTTG
ACCCTTGAGAGCTTCTCGCTGTCCTTTCCGAAGCAATGCCTGTGTGCCCAGGCCATGCAGCCTGCTGTGCCTGCCCAAGGCCAACAACAG
TAGAAGCTGCAGGTGTCCAGAGGATGTGTCCAGCAGTGTGCTTCCATCAGGGGACCTGATGTGTGACTGCCCTCAGGGCTATCAGCTCAA
GAACAATACCTGTGTCAAACAAGAGAACACCTGTCTTCGCAACCAGTATCGCTGCAGCAACGGGAACTGTATCAACAGCATTTGGTGGTG
TGACTTTGACAACGACTGTGGAGACATGAGCGATGAGAGAAACTGCCCTACCACCATCTGTGACCTGGACACCCAGTTTCGTTGCCAGGA
GTCTGGGACTTGTATCCCACTGTCCTATAAATGTGACCTTGAGGATGACTGTGGAGACAACAGTGATGAAAGTCATTGTGAAATGCACCA
GTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGTGACGGGGACAACGACTGCAGGGACTGGTC
TGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGAAACGGGCACTGCATCCCCCAGCGGTGGGC
GTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAGAAGTGCAATGGATTCCGCTGCCCAAACGG
CACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGATGAACAGCACTGCGAGCCCCTCTGTACGCA
CTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGACGGAATCATCCAGTGCCGCGACGGGTCCGA
TGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAGTTCGGTTTCCAGTGTCAGAATGGAGTGTG
CATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCCAACTGCGAAAACCCCACAGAAGCCCCAAA
CTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAATGTGACAGGGAGAACGACTGTGGGGACTG
GTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTACCGCTGCAG
CAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCCTTGCTTGC
AAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGTATTCCCAA
CTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCAGTTACAAA
TGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGT
TCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCA
GTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACA
GCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAA
TCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATAC
ATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTA
CCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGT
CCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAA
TTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTT
CAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAAC
CAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGA
AGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTC
CAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATAT
CCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGA
TTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTC
AAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATT
CTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGG
GAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCA
TATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCAC
CCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTT
TTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAA
GTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTA

>85247_85247_2_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000525532_SYTL2_chr11_85428573_ENST00000389960_length(amino acids)=870AA_BP=499
MRASRCPFRSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCD
FDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSD
EANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF
MDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNC
SRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLAN
VTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVP
AFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNP
VYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVP
GKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTN

--------------------------------------------------------------
>85247_85247_3_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000527934_SYTL2_chr11_85428573_ENST00000389960_length(transcript)=2874nt_BP=785nt
AAAGTATGGTTTGCAACCAGTAGCATCTGCATCTCCTTGGAACTTGTTAGAAATGTAGAATCTCTGACCTCACCCCAGACCTACAGAGTC
AGAATCTGCATGCTAATAAGCCCCCAGGTCCTGTGTGCTCCACAATGCATTTGAGGAGCACTCATGTGGAATGCAGACTTGCCCCTTTCC
TTTCTGGCATTCTCATCTCTGAACCAGGTCGTGGAGTAGTTGCGGTTGAATTAACTAGAACACAATGCTTTGCCTCAGTAGGAATTCTCT
TAGCCACCCTGTGCCTCCTCAGCCACCTGTTTCTTTCACCAGCCCCTGCAAAAGCAAACTTATCTGAATATTAACCGAAATCAAATATAG
TAAGGGAAATCTACTCCCCAAAAGGGAAAAGAATATTGCCTCTTCTGACAACCCATTATACATGATTTCTAGATTAGCCGCTGCTCAGAG
CTGTGCCAGTCACTGGCCTCCCTCAGCAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTACCG
CTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCCTT
GCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGTAT
TCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCAGT
TACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAA
GTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAA
TATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAA
AAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAAC
CTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCG
GGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAG
ATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGA
GCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCA
TCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCC
TATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAA
ATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTC
AGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAA
GATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGAC
AAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCC
AAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGC
TGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACC
ACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGG
AGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGA
ATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAG
TGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTT
ATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGC
AACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAAT

>85247_85247_3_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000527934_SYTL2_chr11_85428573_ENST00000389960_length(amino acids)=493AA_BP=122
MISRLAAAQSCASHWPPSADSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFE
FECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSG
DFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKT
QKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKEC
LDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYG

--------------------------------------------------------------
>85247_85247_4_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000532694_SYTL2_chr11_85428573_ENST00000389960_length(transcript)=3527nt_BP=1438nt
ACAGAAAGTCCCGAGTTATGTTTCCTCCGTTTTGGGAGCTCAGCACTGATTTTACTCTCTCTGACTGAGCATCTCACGGTGATCAGCTCA
TGCAGACCTCTCGGCACTCCTTTTCTCAAACCACAGGCTGTGTCTGTAGGAGTCCTCTGTTTCTTGAAAGTTCTACTTCCTGGCCTCCTC
TATCACTGCTTCCTAACCTTCTTCCCATCATAGCAAGCATAGAAAATAATATATGTGGAGAGCACTGGGATGAATGGACAAGGATGCTGT
TGTCAAGAGGCAAGCAGCTCTAAGGGTCTGAGGGTCTCAGAATCTCAGCCCACCTGTAACCCATTTGCAGCACACTGACTGGAAGCTGTT
AAATGACCTTTTGTCCCTGAAATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGT
GACGGGGACAACGACTGCAGGGACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGA
AACGGGCACTGCATCCCCCAGCGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAG
AAGTGCAATGGATTCCGCTGCCCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGAT
GAACAGCACTGCGAGCCCCTCTGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGAC
GGAATCATCCAGTGCCGCGACGGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAG
TTCGGTTTCCAGTGTCAGAATGGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCC
AACTGCGAAAACCCCACAGAAGCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAA
TGTGACAGGGAGAACGACTGTGGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCC
ACGTGTCTGCCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGC
TCTGACGAGGAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAA
TGCCACCAACCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCAT
GAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCT
GACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTT
GGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAG
GACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAG
AAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAA
TTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGAT
AACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAA
CTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGAT
CTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGA
GCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAG
CTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAA
GTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCT
CTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGAT
CTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCAT
GTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGC
TAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTG
TTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAG
TCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTC
TGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAA
AACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCT
CAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAA
GAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCG
TATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTT

>85247_85247_4_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000532694_SYTL2_chr11_85428573_ENST00000389960_length(amino acids)=724AA_BP=353
MHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC
PNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQN
GVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYY
RCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKP
VTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADV
KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQL
RWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTN
PIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIA

--------------------------------------------------------------
>85247_85247_5_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000534286_SYTL2_chr11_85428573_ENST00000389960_length(transcript)=3349nt_BP=1260nt
GTGATCAGCTCATGCAGACCTCTCGGCACTCCTTTTCTCAAACCACAGGCTGTGTCTGTAGGAGTCCTCTGTTTCTTGAAAGTTCTACTT
CCTGGCCTCCTCTATCACTGCTTCCTAACCTTCTTCCCATCATAGCAAGCATAGAAAATAATATATGTGGAGAGCACTGGGATGAATGGA
CAAGGATGCTGTTGTCAAGAGAAATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTAT
GTGACGGGGACAACGACTGCAGGGACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCC
GAAACGGGCACTGCATCCCCCAGCGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGA
AGAAGTGCAATGGATTCCGCTGCCCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCG
ATGAACAGCACTGCGAGCCCCTCTGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTG
ACGGAATCATCCAGTGCCGCGACGGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATG
AGTTCGGTTTCCAGTGTCAGAATGGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAG
CCAACTGCGAAAACCCCACAGAAGCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGA
AATGTGACAGGGAGAACGACTGTGGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCT
CCACGTGTCTGCCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATG
GCTCTGACGAGGAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCG
AATGCCACCAACCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCC
ATGAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACC
CTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACT
TTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTA
AGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGA
AGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGA
AATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGG
ATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGA
AACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTG
ATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAA
GAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAG
AGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTG
AAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGC
CTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTG
ATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGC
ATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAA
GCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCT
TGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAA
AGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTAC
TCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTT
AAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGT
CTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCAT
AAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTT
CGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATT

>85247_85247_5_SORL1-SYTL2_SORL1_chr11_121466481_ENST00000534286_SYTL2_chr11_85428573_ENST00000389960_length(amino acids)=788AA_BP=417
MQTSRHSFSQTTGCVCRSPLFLESSTSWPPLSLLPNLLPIIASIENNICGEHWDEWTRMLLSREMHQCRSDEYNCSSGMCIRSSWVCDGD
NDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQH
CEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCE
NPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDE
EACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKL
KRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTL
VVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLAL
QYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SORL1-SYTL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SORL1-SYTL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SORL1-SYTL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource