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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SOS1-MAP4K3 (FusionGDB2 ID:85262)

Fusion Gene Summary for SOS1-MAP4K3

check button Fusion gene summary
Fusion gene informationFusion gene name: SOS1-MAP4K3
Fusion gene ID: 85262
HgeneTgene
Gene symbol

SOS1

MAP4K3

Gene ID

6654

8491

Gene nameSOS Ras/Rac guanine nucleotide exchange factor 1mitogen-activated protein kinase kinase kinase kinase 3
SynonymsGF1|GGF1|GINGF|HGF|NS4|SOS-1GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1
Cytomap

2p22.1

2p22.1

Type of geneprotein-codingprotein-coding
Descriptionson of sevenless homolog 1gingival fibromatosis, hereditary, 1guanine nucleotide exchange factormitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase
Modification date2020032720200313
UniProtAcc.

Q8IVH8

Ensembl transtripts involved in fusion geneENST00000395038, ENST00000402219, 
ENST00000426016, ENST00000428721, 
ENST00000472480, 		ENST00000341681, 
ENST00000437545, ENST00000484274, 
ENST00000536018, ENST00000474502, 
ENST00000263881, 
Fusion gene scores* DoF score9 X 12 X 9=9728 X 8 X 7=448
# samples 1411
** MAII scorelog2(14/972*10)=-2.79552948666081
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/448*10)=-2.02599520853294
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOS1 [Title/Abstract] AND MAP4K3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSOS1(39278285)-MAP4K3(39605264), # samples:3
SOS1(39283843)-MAP4K3(39605264), # samples:3
Anticipated loss of major functional domain due to fusion event.SOS1-MAP4K3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SOS1-MAP4K3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP4K3

GO:0006468

protein phosphorylation

9275185

TgeneMAP4K3

GO:0009411

response to UV

9275185

TgeneMAP4K3

GO:0034612

response to tumor necrosis factor

9275185

TgeneMAP4K3

GO:0035556

intracellular signal transduction

9275185


check buttonFusion gene breakpoints across SOS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP4K3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8238-01ASOS1chr2

39347477

-MAP4K3chr2

39542529

-
ChimerDB4TGCTTCGA-XE-AANR-01ASOS1chr2

39278285

-MAP4K3chr2

39605264

-
ChimerDB4TGCTTCGA-XE-AANRSOS1chr2

39278285

-MAP4K3chr2

39605264

-
ChimerDB4THCATCGA-EL-A3H8-01ASOS1chr2

39283843

-MAP4K3chr2

39605264

-
ChimerDB4THCATCGA-EL-A3H8SOS1chr2

39283842

-MAP4K3chr2

39605264

-


Top

Fusion Gene ORF analysis for SOS1-MAP4K3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000395038ENST00000341681SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000341681SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000341681SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000437545SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000437545SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000437545SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000484274SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000484274SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000484274SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000395038ENST00000536018SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-5UTRENST00000402219ENST00000341681SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000341681SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000341681SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000437545SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000437545SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000437545SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000484274SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000484274SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000484274SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000402219ENST00000536018SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-5UTRENST00000426016ENST00000341681SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000341681SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000341681SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000437545SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000437545SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000437545SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000484274SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000484274SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000484274SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000426016ENST00000536018SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-5UTRENST00000428721ENST00000341681SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000341681SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000341681SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000437545SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000437545SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000437545SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000484274SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000484274SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-5UTRENST00000428721ENST00000484274SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000395038ENST00000474502SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-intronENST00000395038ENST00000474502SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000395038ENST00000474502SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000395038ENST00000474502SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000395038ENST00000484274SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-intronENST00000395038ENST00000536018SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000395038ENST00000536018SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000395038ENST00000536018SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000402219ENST00000474502SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-intronENST00000402219ENST00000474502SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000402219ENST00000474502SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000402219ENST00000474502SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000402219ENST00000484274SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-intronENST00000402219ENST00000536018SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000402219ENST00000536018SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000402219ENST00000536018SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000426016ENST00000474502SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-intronENST00000426016ENST00000474502SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000426016ENST00000474502SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000426016ENST00000474502SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000426016ENST00000484274SOS1chr2

39347477

-MAP4K3chr2

39542529

-
5CDS-intronENST00000426016ENST00000536018SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000426016ENST00000536018SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000426016ENST00000536018SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000428721ENST00000474502SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000428721ENST00000474502SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000428721ENST00000474502SOS1chr2

39283842

-MAP4K3chr2

39605264

-
5CDS-intronENST00000428721ENST00000536018SOS1chr2

39278285

-MAP4K3chr2

39605264

-
5CDS-intronENST00000428721ENST00000536018SOS1chr2

39283843

-MAP4K3chr2

39605264

-
5CDS-intronENST00000428721ENST00000536018SOS1chr2

39283842

-MAP4K3chr2

39605264

-
Frame-shiftENST00000426016ENST00000263881SOS1chr2

39347477

-MAP4K3chr2

39542529

-
Frame-shiftENST00000426016ENST00000263881SOS1chr2

39278285

-MAP4K3chr2

39605264

-
Frame-shiftENST00000426016ENST00000263881SOS1chr2

39283843

-MAP4K3chr2

39605264

-
Frame-shiftENST00000426016ENST00000263881SOS1chr2

39283842

-MAP4K3chr2

39605264

-
Frame-shiftENST00000426016ENST00000341681SOS1chr2

39347477

-MAP4K3chr2

39542529

-
Frame-shiftENST00000426016ENST00000437545SOS1chr2

39347477

-MAP4K3chr2

39542529

-
Frame-shiftENST00000428721ENST00000263881SOS1chr2

39278285

-MAP4K3chr2

39605264

-
Frame-shiftENST00000428721ENST00000263881SOS1chr2

39283843

-MAP4K3chr2

39605264

-
Frame-shiftENST00000428721ENST00000263881SOS1chr2

39283842

-MAP4K3chr2

39605264

-
In-frameENST00000395038ENST00000263881SOS1chr2

39347477

-MAP4K3chr2

39542529

-
In-frameENST00000395038ENST00000263881SOS1chr2

39278285

-MAP4K3chr2

39605264

-
In-frameENST00000395038ENST00000263881SOS1chr2

39283843

-MAP4K3chr2

39605264

-
In-frameENST00000395038ENST00000263881SOS1chr2

39283842

-MAP4K3chr2

39605264

-
In-frameENST00000395038ENST00000341681SOS1chr2

39347477

-MAP4K3chr2

39542529

-
In-frameENST00000395038ENST00000437545SOS1chr2

39347477

-MAP4K3chr2

39542529

-
In-frameENST00000402219ENST00000263881SOS1chr2

39347477

-MAP4K3chr2

39542529

-
In-frameENST00000402219ENST00000263881SOS1chr2

39278285

-MAP4K3chr2

39605264

-
In-frameENST00000402219ENST00000263881SOS1chr2

39283843

-MAP4K3chr2

39605264

-
In-frameENST00000402219ENST00000263881SOS1chr2

39283842

-MAP4K3chr2

39605264

-
In-frameENST00000402219ENST00000341681SOS1chr2

39347477

-MAP4K3chr2

39542529

-
In-frameENST00000402219ENST00000437545SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-3CDSENST00000428721ENST00000263881SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-3CDSENST00000428721ENST00000341681SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-3CDSENST00000428721ENST00000437545SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-3CDSENST00000472480ENST00000263881SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-3CDSENST00000472480ENST00000263881SOS1chr2

39278285

-MAP4K3chr2

39605264

-
intron-3CDSENST00000472480ENST00000263881SOS1chr2

39283843

-MAP4K3chr2

39605264

-
intron-3CDSENST00000472480ENST00000263881SOS1chr2

39283842

-MAP4K3chr2

39605264

-
intron-3CDSENST00000472480ENST00000341681SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-3CDSENST00000472480ENST00000437545SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-5UTRENST00000428721ENST00000536018SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-5UTRENST00000472480ENST00000341681SOS1chr2

39278285

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000341681SOS1chr2

39283843

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000341681SOS1chr2

39283842

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000437545SOS1chr2

39278285

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000437545SOS1chr2

39283843

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000437545SOS1chr2

39283842

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000484274SOS1chr2

39278285

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000484274SOS1chr2

39283843

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000484274SOS1chr2

39283842

-MAP4K3chr2

39605264

-
intron-5UTRENST00000472480ENST00000536018SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-intronENST00000428721ENST00000474502SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-intronENST00000428721ENST00000484274SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-intronENST00000472480ENST00000474502SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-intronENST00000472480ENST00000474502SOS1chr2

39278285

-MAP4K3chr2

39605264

-
intron-intronENST00000472480ENST00000474502SOS1chr2

39283843

-MAP4K3chr2

39605264

-
intron-intronENST00000472480ENST00000474502SOS1chr2

39283842

-MAP4K3chr2

39605264

-
intron-intronENST00000472480ENST00000484274SOS1chr2

39347477

-MAP4K3chr2

39542529

-
intron-intronENST00000472480ENST00000536018SOS1chr2

39278285

-MAP4K3chr2

39605264

-
intron-intronENST00000472480ENST00000536018SOS1chr2

39283843

-MAP4K3chr2

39605264

-
intron-intronENST00000472480ENST00000536018SOS1chr2

39283842

-MAP4K3chr2

39605264

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402219SOS1chr239278285-ENST00000263881MAP4K3chr239605264-48469054134931150
ENST00000395038SOS1chr239278285-ENST00000263881MAP4K3chr239605264-48338922834801150
ENST00000402219SOS1chr239283843-ENST00000263881MAP4K3chr239605264-44925514131391032
ENST00000395038SOS1chr239283843-ENST00000263881MAP4K3chr239605264-44795382831261032
ENST00000402219SOS1chr239283842-ENST00000263881MAP4K3chr239605264-44925514131391032
ENST00000395038SOS1chr239283842-ENST00000263881MAP4K3chr239605264-44795382831261032
ENST00000402219SOS1chr239347477-ENST00000263881MAP4K3chr239542529-3247128411894617
ENST00000402219SOS1chr239347477-ENST00000437545MAP4K3chr239542529-3172128411831596
ENST00000402219SOS1chr239347477-ENST00000341681MAP4K3chr239542529-3167128411831596
ENST00000395038SOS1chr239347477-ENST00000263881MAP4K3chr239542529-3234115281881617
ENST00000395038SOS1chr239347477-ENST00000437545MAP4K3chr239542529-3159115281818596
ENST00000395038SOS1chr239347477-ENST00000341681MAP4K3chr239542529-3154115281818596

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402219ENST00000263881SOS1chr239278285-MAP4K3chr239605264-4.73E-050.9999528
ENST00000395038ENST00000263881SOS1chr239278285-MAP4K3chr239605264-4.66E-050.9999534
ENST00000402219ENST00000263881SOS1chr239283843-MAP4K3chr239605264-7.14E-050.9999286
ENST00000395038ENST00000263881SOS1chr239283843-MAP4K3chr239605264-7.05E-050.9999294
ENST00000402219ENST00000263881SOS1chr239283842-MAP4K3chr239605264-7.14E-050.9999286
ENST00000395038ENST00000263881SOS1chr239283842-MAP4K3chr239605264-7.05E-050.9999294
ENST00000402219ENST00000263881SOS1chr239347477-MAP4K3chr239542529-0.000354160.9996458
ENST00000402219ENST00000437545SOS1chr239347477-MAP4K3chr239542529-0.0004630590.999537
ENST00000402219ENST00000341681SOS1chr239347477-MAP4K3chr239542529-0.0004505490.99954945
ENST00000395038ENST00000263881SOS1chr239347477-MAP4K3chr239542529-0.0003490580.99965096
ENST00000395038ENST00000437545SOS1chr239347477-MAP4K3chr239542529-0.0004588560.99954116
ENST00000395038ENST00000341681SOS1chr239347477-MAP4K3chr239542529-0.0004474410.99955255

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Fusion Genomic Features for SOS1-MAP4K3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SOS1-MAP4K3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39278285/chr2:39605264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP4K3

Q8IVH8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP4K3chr2:39278285chr2:39605264ENST00000263881034556_86732895.0DomainCNH
TgeneMAP4K3chr2:39278285chr2:39605264ENST00000341681033556_86732874.0DomainCNH
TgeneMAP4K3chr2:39283842chr2:39605264ENST00000263881034556_86732895.0DomainCNH
TgeneMAP4K3chr2:39283842chr2:39605264ENST00000341681033556_86732874.0DomainCNH
TgeneMAP4K3chr2:39283843chr2:39605264ENST00000263881034556_86732895.0DomainCNH
TgeneMAP4K3chr2:39283843chr2:39605264ENST00000341681033556_86732874.0DomainCNH
TgeneMAP4K3chr2:39347477chr2:39542529ENST000002638811134556_867306895.0DomainCNH
TgeneMAP4K3chr2:39347477chr2:39542529ENST000003416811133556_867306874.0DomainCNH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-6231258_12612881334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-7241258_12612881334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-4231258_12611701334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-5241258_12611701334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-4231258_12611701334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-5241258_12611701334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-1231258_1261291334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-2241258_1261291334.0Compositional biasNote=Poly-Pro
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623200_3902881334.0DomainDH
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623444_5482881334.0DomainPH
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623597_7412881334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39278285chr2:39605264ENST00000402219-623780_10192881334.0DomainRas-GEF
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724200_3902881334.0DomainDH
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724444_5482881334.0DomainPH
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724597_7412881334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39278285chr2:39605264ENST00000426016-724780_10192881334.0DomainRas-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423200_3901701334.0DomainDH
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423444_5481701334.0DomainPH
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423597_7411701334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000402219-423780_10191701334.0DomainRas-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524200_3901701334.0DomainDH
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524444_5481701334.0DomainPH
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524597_7411701334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283842chr2:39605264ENST00000426016-524780_10191701334.0DomainRas-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423200_3901701334.0DomainDH
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423444_5481701334.0DomainPH
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423597_7411701334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000402219-423780_10191701334.0DomainRas-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524200_3901701334.0DomainDH
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524444_5481701334.0DomainPH
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524597_7411701334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39283843chr2:39605264ENST00000426016-524780_10191701334.0DomainRas-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123200_390291334.0DomainDH
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123444_548291334.0DomainPH
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123597_741291334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000402219-123780_1019291334.0DomainRas-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224200_390291334.0DomainDH
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224444_548291334.0DomainPH
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224597_741291334.0DomainN-terminal Ras-GEF
HgeneSOS1chr2:39347477chr2:39542529ENST00000426016-224780_1019291334.0DomainRas-GEF
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000026388103416_27332895.0DomainProtein kinase
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000034168103316_27332874.0DomainProtein kinase
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000026388103416_27332895.0DomainProtein kinase
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000034168103316_27332874.0DomainProtein kinase
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000026388103416_27332895.0DomainProtein kinase
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000034168103316_27332874.0DomainProtein kinase
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000263881113416_273306895.0DomainProtein kinase
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000341681113316_273306874.0DomainProtein kinase
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000026388103422_3032895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39278285chr2:39605264ENST0000034168103322_3032874.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000026388103422_3032895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283842chr2:39605264ENST0000034168103322_3032874.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000026388103422_3032895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39283843chr2:39605264ENST0000034168103322_3032874.0Nucleotide bindingATP
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000263881113422_30306895.0Nucleotide bindingATP
TgeneMAP4K3chr2:39347477chr2:39542529ENST00000341681113322_30306874.0Nucleotide bindingATP


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Fusion Gene Sequence for SOS1-MAP4K3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85262_85262_1_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4833nt_BP=892nt
CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG
ACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGTATGTTGAAGAATT
AATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAAGTTTCCCTCATCC
AATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAGTAGAAAAAATTCA
TCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACATTTCTGCAGACAT
TTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGTGTGCTGACAAGGT
ATTGATGGATATGTTTCATCAAGATGTAGAAGATATTAATATATTATCTTTAACTGACGAAGAGCCTTCCACCTCAGGAGAACAAACTTA
CTATGATTTGGTAAAAGCATTTATGGCAGAAATTCGACAATATATAAGGGAACTAAATCTAATTATAAAAGTTTTTAGAGAGCCCTTTGT
CTCCAATTCAAAATTGTTTTCAGCTAATGATGTAGAAAATATATTTAGTCGCATAGTAGATATACATGAACTTAGTGTAAAGTTACTGGG
CCATATAGAAGATACAGTAGAAATGACAGATGAAGGCAGTCCCCATCCACTAGTAGGAAGCTGCTTTGAAGACTTAGCAGAGGCACGGAA
TGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAGAAATTATTATGAT
GAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGGAGTTTTGTGGAGG
TGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACACTGCAGGGATTATA
TTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGAAATTGGCTGATTT
TGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAGAAGTTGCAGCTGT
TGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTCAGCCTCCTATGTT
TGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGAAATGGTCAAATAG
TTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATCCTTTTGTAACACA
ACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCGATGATGATGATCC
TGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTTTGGCCA
AGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACAGTTCAGAAGAAAT
ATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCT
TCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTC
AACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAA
TCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCC
ACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACA
TAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGG
TGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTT
GATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTAC
ATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTA
TGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAA
AATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAG
CATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTT
TGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGA
GACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGA
TACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCAC
CTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATC
TAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAAC
TGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTA
GAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTA
TTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGT
TATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTAC
TTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTA
GTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATT
TAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACAC
TGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACA
AATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATC
CTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTG
TGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTA
ACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGAC
TTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTG
GTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATAT
GTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAA

>85262_85262_1_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1150AA_BP=288
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMT
DEGSPHPLVGSCFEDLAEARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV
TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL
CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE
LLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLD
LQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPM
SGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNG
CPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPV
AIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQE
YPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIV

--------------------------------------------------------------
>85262_85262_2_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4846nt_BP=905nt
CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC
CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGT
ATGTTGAAGAATTAATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAA
GTTTCCCTCATCCAATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAG
TAGAAAAAATTCATCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACA
TTTCTGCAGACATTTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGT
GTGCTGACAAGGTATTGATGGATATGTTTCATCAAGATGTAGAAGATATTAATATATTATCTTTAACTGACGAAGAGCCTTCCACCTCAG
GAGAACAAACTTACTATGATTTGGTAAAAGCATTTATGGCAGAAATTCGACAATATATAAGGGAACTAAATCTAATTATAAAAGTTTTTA
GAGAGCCCTTTGTCTCCAATTCAAAATTGTTTTCAGCTAATGATGTAGAAAATATATTTAGTCGCATAGTAGATATACATGAACTTAGTG
TAAAGTTACTGGGCCATATAGAAGATACAGTAGAAATGACAGATGAAGGCAGTCCCCATCCACTAGTAGGAAGCTGCTTTGAAGACTTAG
CAGAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAG
AAATTATTATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGG
AGTTTTGTGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACAC
TGCAGGGATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGA
AATTGGCTGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAG
AAGTTGCAGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTC
AGCCTCCTATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGA
AATGGTCAAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATC
CTTTTGTAACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCG
ATGATGATGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGA
TAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACA
GTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTG
CAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATG
AATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTA
CTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTC
CCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAAC
AACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTA
AAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAA
GAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCC
CTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAG
GGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTT
CTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAG
CACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTC
CACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAG
TGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCC
AACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGT
CATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTA
GAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGG
AAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTG
ACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTT
ACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTG
CTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTAT
GTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTT
TAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTT
ATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTT
AATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGC
ATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATA
TTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAG
AATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACA
CTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCA
TATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAG
GAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCT
CTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATG

>85262_85262_2_SOS1-MAP4K3_SOS1_chr2_39278285_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1150AA_BP=288
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMT
DEGSPHPLVGSCFEDLAEARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV
TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL
CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE
LLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLD
LQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPM
SGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNG
CPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPV
AIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQE
YPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIV

--------------------------------------------------------------
>85262_85262_3_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4479nt_BP=538nt
CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG
ACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGTATGTTGAAGAATT
AATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAAGTTTCCCTCATCC
AATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAGTAGAAAAAATTCA
TCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACATTTCTGCAGACAT
TTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGTGTGCTGACAAGGC
ACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAGAAATTAT
TATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGGAGTTTTG
TGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACACTGCAGGG
ATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGAAATTGGC
TGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAGAAGTTGC
AGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTCAGCCTCC
TATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGAAATGGTC
AAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATCCTTTTGT
AACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCGATGATGA
TGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTT
TGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACAGTTCAGA
AGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAA
GAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAA
ACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGA
TGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATT
ACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAA
TGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCA
TATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCA
GTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAG
GTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTT
TGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATC
AGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCA
GACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAG
AATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCG
ATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGA
GAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGA
ACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTT
TAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAG
GCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTA
ACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGT
AATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATT
CATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATA
ATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAAT
TCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATAT
GTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAA
GTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGC
TCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGC
AGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTG
CAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGA
ACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCT
TTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTA
GTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTG
GTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGG

>85262_85262_3_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------
>85262_85262_4_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4492nt_BP=551nt
CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC
CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGT
ATGTTGAAGAATTAATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAA
GTTTCCCTCATCCAATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAG
TAGAAAAAATTCATCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACA
TTTCTGCAGACATTTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGT
GTGCTGACAAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGC
AGCAAGAAATTATTATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTT
GCATGGAGTTTTGTGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAG
AAACACTGCAGGGATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTC
ATGTGAAATTGGCTGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGG
CTCCAGAAGTTGCAGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAG
AGCTTCAGCCTCCTATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATA
AAATGAAATGGTCAAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTAC
AGCATCCTTTTGTAACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATG
ATTTCGATGATGATGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCT
CAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTT
TGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTT
TAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATG
ATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGC
ATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCAC
CACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTAT
GTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAA
CACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAG
ATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGC
TATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATT
TACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGA
AATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTAT
GTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATAC
CATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCA
ACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATG
TAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGA
AATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGC
AAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGG
TTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGT
GCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCT
TCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACA
CAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGA
ATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTA
ATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGT
ATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTT
AATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCT
ATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTT
TTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCA
TGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATG
ATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCC
TTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACA
TCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTT
TTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATT

>85262_85262_4_SOS1-MAP4K3_SOS1_chr2_39283842_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------
>85262_85262_5_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4479nt_BP=538nt
CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG
ACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGTATGTTGAAGAATT
AATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAAGTTTCCCTCATCC
AATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAGTAGAAAAAATTCA
TCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACATTTCTGCAGACAT
TTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGTGTGCTGACAAGGC
ACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGCAGCAAGAAATTAT
TATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTTGCATGGAGTTTTG
TGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAGAAACACTGCAGGG
ATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTCATGTGAAATTGGC
TGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGGCTCCAGAAGTTGC
AGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAGAGCTTCAGCCTCC
TATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATAAAATGAAATGGTC
AAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTACAGCATCCTTTTGT
AACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATGATTTCGATGATGA
TGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTT
TGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACAGTTCAGA
AGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAA
GAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAA
ACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGA
TGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATT
ACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAA
TGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCA
TATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCA
GTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAG
GTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTT
TGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATC
AGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCA
GACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAG
AATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCG
ATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGA
GAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGA
ACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTT
TAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAG
GCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTA
ACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGT
AATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATT
CATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATA
ATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAAT
TCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATAT
GTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAA
GTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGC
TCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGC
AGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTG
CAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGA
ACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCT
TTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTA
GTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTG
GTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGG

>85262_85262_5_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000395038_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------
>85262_85262_6_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(transcript)=4492nt_BP=551nt
CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC
CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCTAATGATGATGCTCTTCAGT
ATGTTGAAGAATTAATTTTGCAATTATTAAATATGCTATGCCAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAA
GTTTCCCTCATCCAATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGAAACCCTTTATCTCTCCCAG
TAGAAAAAATTCATCCTTTATTAAAGGAGGTCCTAGGTTATAAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACA
TTTCTGCAGACATTTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAAGATATTAAAGTGGCAATGT
GTGCTGACAAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGGAGAAGACTTTGCAGTTGTGC
AGCAAGAAATTATTATGATGAAAGACTGTAAACACCCAAATATTGTTGCTTATTTTGGAAGCTATCTCAGGCGAGATAAGCTTTGGATTT
GCATGGAGTTTTGTGGAGGTGGTTCTTTACAGGATATTTATCACGTAACTGGACCTCTGTCAGAACTGCAAATTGCATATGTTAGCAGAG
AAACACTGCAGGGATTATATTATCTTCACAGTAAAGGAAAAATGCACAGAGATATAAAGGGAGCTAACATTCTATTAACGGATAATGGTC
ATGTGAAATTGGCTGATTTTGGAGTATCTGCACAGATAACAGCTACAATTGCCAAACGGAAGTCTTTCATTGGCACACCATATTGGATGG
CTCCAGAAGTTGCAGCTGTTGAGAGGAAGGGGGGTTACAATCAACTCTGTGATCTCTGGGCAGTGGGAATCACTGCCATAGAACTTGCAG
AGCTTCAGCCTCCTATGTTTGACTTACACCCAATGAGAGCATTATTTCTAATGACAAAAAGCAATTTTCAGCCTCCTAAACTAAAGGATA
AAATGAAATGGTCAAATAGTTTTCATCACTTTGTGAAAATGGCACTTACCAAAAATCCGAAAAAAAGACCTACTGCTGAAAAATTATTAC
AGCATCCTTTTGTAACACAACATTTGACACGGTCTTTGGCAATCGAGCTGTTGGATAAAGTAAATAATCCAGATCATTCCACTTACCATG
ATTTCGATGATGATGATCCTGAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCT
CAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTT
TGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTT
TAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATG
ATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGC
ATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCAC
CACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTAT
GTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAA
CACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAG
ATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGC
TATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATT
TACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGA
AATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTAT
GTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATAC
CATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCA
ACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATG
TAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGA
AATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGC
AAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGG
TTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGT
GCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCT
TCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACA
CAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGA
ATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTA
ATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGT
ATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTT
AATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCT
ATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTT
TTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCA
TGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATG
ATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCC
TTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACA
TCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTT
TTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATT

>85262_85262_6_SOS1-MAP4K3_SOS1_chr2_39283843_ENST00000402219_MAP4K3_chr2_39605264_ENST00000263881_length(amino acids)=1032AA_BP=170
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADA
QSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKARNVNTGELA
AIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK
MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA
LFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVP
HRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEE
LHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALG
NGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEG
IYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWC
QKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNST
SSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEI

--------------------------------------------------------------
>85262_85262_7_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000263881_length(transcript)=3234nt_BP=115nt
CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG
ACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACG
CTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGACAGTGATGGTTT
TTTGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTT
TTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGA
TGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAAT
GCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACC
ACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATT
ATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCC
AACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCC
AGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACA
GCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAA
TTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAG
GAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCT
ATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTAT
ACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTT
CAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCA
TGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAG
GAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAAT
GCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGT
GGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTT
GTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGT
CTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCA
CACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAA
GAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGT
TAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATT
GTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTT
TTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGT
CTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTC
TTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTAC
CATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATA
TGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGAT
CCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACA
CATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACAC
TTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTA

>85262_85262_7_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=617AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYY
TARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQG
TIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGAC
FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYAR
QMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEM
LVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFD

--------------------------------------------------------------
>85262_85262_8_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000341681_length(transcript)=3154nt_BP=115nt
CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG
ACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACG
CTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATCTGCAACTGGAATA
TGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGT
CGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCC
TAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGC
AAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCA
GTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACC
AAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAAT
TCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAA
TGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGG
TAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACA
CAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAG
AAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTAT
GTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTG
TGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATC
AGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAA
TCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAG
TGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTT
CAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGG
TCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGA
AGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGG
TATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAA
CTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGT
AAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGG
CAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAAT
GGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTA
AGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATA
ATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAA
CATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTAT
TAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTT
TTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCT
CATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTA
TATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAAC
TAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTT

>85262_85262_8_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

--------------------------------------------------------------
>85262_85262_9_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000437545_length(transcript)=3159nt_BP=115nt
CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG
ACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACG
CTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATCTGCAACTGGAATA
TGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGT
CGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCC
TAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGC
AAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCA
GTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACC
AAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAAT
TCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAA
TGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGG
TAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACA
CAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAG
AAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTAT
GTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTG
TGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATC
AGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAA
TCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAG
TGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTT
CAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGG
TCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGA
AGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGG
TATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAA
CTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGT
AAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGG
CAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAAT
GGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTA
AGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATA
ATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAA
CATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTAT
TAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTT
TTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCT
CATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTA
TATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAAC
TAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTT

>85262_85262_9_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000395038_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

--------------------------------------------------------------
>85262_85262_10_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000263881_length(transcript)=3247nt_BP=128nt
CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC
CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAG
AAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCG
ACAGTGATGGTTTTTTGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACC
AAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAG
ATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCA
TACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAG
TTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAAC
GAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTA
ATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCAT
CATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAA
CATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGC
TTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACA
GAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGG
GCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACA
TAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTA
GAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGA
CAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGAT
TAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCT
GGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGAT
CTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTT
ACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGC
TGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTA
GCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGA
AGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAA
ATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATAC
ATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCA
TTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAA
GCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTT
GTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCAC
AGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCAC
TAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGC
CTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATAT
AATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTA
GCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTA
TGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTTTTAACATGCTGTTG

>85262_85262_10_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=617AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYY
TARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQG
TIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGAC
FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYAR
QMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEM
LVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFD

--------------------------------------------------------------
>85262_85262_11_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000341681_length(transcript)=3167nt_BP=128nt
CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC
CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAG
AAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATC
TGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATC
AGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTT
TGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGT
CAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAA
TGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAA
AGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGT
GTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATA
CCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGC
TATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTG
CTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGT
GTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAA
TGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGT
ACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCAT
GGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTA
TAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGT
GCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATA
GCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGT
ACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATT
AATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATT
TTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTAT
TTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTA
TCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAA
AATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTT
TTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGAT
ATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAG
CAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAA
CAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAAT
TAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATT
TCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAAT
TTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCC
AATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATAC
ACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAA

>85262_85262_11_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

--------------------------------------------------------------
>85262_85262_12_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000437545_length(transcript)=3172nt_BP=128nt
CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC
CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAG
AAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATC
TGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATC
AGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTT
TGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGT
CAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAA
TGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAA
AGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGT
GTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATA
CCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGC
TATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTG
CTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGT
GTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAA
TGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGT
ACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCAT
GGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTA
TAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGT
GCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATA
GCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGT
ACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATT
AATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATT
TTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTAT
TTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTA
TCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAA
AATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTT
TTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGAT
ATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAG
CAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAA
CAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAAT
TAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATT
TCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAAT
TTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCC
AATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATAC
ACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAA

>85262_85262_12_SOS1-MAP4K3_SOS1_chr2_39347477_ENST00000402219_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=596AA_BP=29
MQAQQLPYEFFSEENAPKWRGLLVPALKKPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYF
LGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRP
PPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINP
DTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPR
KFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDF
NQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGM

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Fusion Gene PPI Analysis for SOS1-MAP4K3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SOS1-MAP4K3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SOS1-MAP4K3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource