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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AVEN-MEIS2 (FusionGDB2 ID:8531)

Fusion Gene Summary for AVEN-MEIS2

check button Fusion gene summary
Fusion gene informationFusion gene name: AVEN-MEIS2
Fusion gene ID: 8531
HgeneTgene
Gene symbol

AVEN

MEIS2

Gene ID

57099

4212

Gene nameapoptosis and caspase activation inhibitorMeis homeobox 2
SynonymsPDCD12CPCMR|HsT18361|MRG1
Cytomap

15q14

15q14

Type of geneprotein-codingprotein-coding
Descriptioncell death regulator Avenapoptosis, caspase activation inhibitorprogrammed cell death 12homeobox protein Meis2Meis homolog 2Meis1, myeloid ecotropic viral integration site 1 homolog 2Meis1-related gene 1TALE homeobox protein Meis2meis1-related protein 1
Modification date2020031320200313
UniProtAcc.

O14770

Ensembl transtripts involved in fusion geneENST00000306730, ENST00000558136, 
ENST00000559408, ENST00000219869, 
ENST00000338564, ENST00000340545, 
ENST00000382766, ENST00000397620, 
ENST00000397624, ENST00000424352, 
ENST00000444725, ENST00000557796, 
ENST00000559085, ENST00000559561, 
ENST00000561208, 
Fusion gene scores* DoF score7 X 6 X 5=21015 X 13 X 4=780
# samples 815
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AVEN [Title/Abstract] AND MEIS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAVEN(34330980)-MEIS2(37242601), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAVEN

GO:0043066

negative regulation of apoptotic process

10949025

TgeneMEIS2

GO:0045931

positive regulation of mitotic cell cycle

26512644

TgeneMEIS2

GO:0045944

positive regulation of transcription by RNA polymerase II

10764806

TgeneMEIS2

GO:0110024

positive regulation of cardiac muscle myoblast proliferation

26512644


check buttonFusion gene breakpoints across AVEN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MEIS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5730-11AAVENchr15

34330980

-MEIS2chr15

37242601

-


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Fusion Gene ORF analysis for AVEN-MEIS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306730ENST00000559408AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000219869AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000338564AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000340545AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000382766AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000397620AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000397624AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000424352AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000444725AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000557796AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000559085AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000559561AVENchr15

34330980

-MEIS2chr15

37242601

-
In-frameENST00000306730ENST00000561208AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000219869AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000338564AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000340545AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000382766AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000397620AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000397624AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000424352AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000444725AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000557796AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000559085AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000559561AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-3CDSENST00000558136ENST00000561208AVENchr15

34330980

-MEIS2chr15

37242601

-
intron-intronENST00000558136ENST00000559408AVENchr15

34330980

-MEIS2chr15

37242601

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306730AVENchr1534330980-ENST00000338564MEIS2chr1537242601-3878397130909259
ENST00000306730AVENchr1534330980-ENST00000561208MEIS2chr1537242601-3896397130930266
ENST00000306730AVENchr1534330980-ENST00000397624MEIS2chr1537242601-2148397130681183
ENST00000306730AVENchr1534330980-ENST00000382766MEIS2chr1537242601-2051397130909259
ENST00000306730AVENchr1534330980-ENST00000444725MEIS2chr1537242601-2147397130681183
ENST00000306730AVENchr1534330980-ENST00000340545MEIS2chr1537242601-2147397130681183
ENST00000306730AVENchr1534330980-ENST00000559085MEIS2chr1537242601-1944397130702190
ENST00000306730AVENchr1534330980-ENST00000219869MEIS2chr1537242601-1944397130702190
ENST00000306730AVENchr1534330980-ENST00000557796MEIS2chr1537242601-1769397130681183
ENST00000306730AVENchr1534330980-ENST00000397620MEIS2chr1537242601-1331397130681183
ENST00000306730AVENchr1534330980-ENST00000424352MEIS2chr1537242601-1350397130702190
ENST00000306730AVENchr1534330980-ENST00000559561MEIS2chr1537242601-684397130681183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306730ENST00000338564AVENchr1534330980-MEIS2chr1537242601-0.084025910.9159741
ENST00000306730ENST00000561208AVENchr1534330980-MEIS2chr1537242601-0.0741401760.92585975
ENST00000306730ENST00000397624AVENchr1534330980-MEIS2chr1537242601-0.18703440.8129656
ENST00000306730ENST00000382766AVENchr1534330980-MEIS2chr1537242601-0.164741710.83525825
ENST00000306730ENST00000444725AVENchr1534330980-MEIS2chr1537242601-0.184531440.8154686
ENST00000306730ENST00000340545AVENchr1534330980-MEIS2chr1537242601-0.184531440.8154686
ENST00000306730ENST00000559085AVENchr1534330980-MEIS2chr1537242601-0.242606880.7573931
ENST00000306730ENST00000219869AVENchr1534330980-MEIS2chr1537242601-0.242606880.7573931
ENST00000306730ENST00000557796AVENchr1534330980-MEIS2chr1537242601-0.163418750.8365813
ENST00000306730ENST00000397620AVENchr1534330980-MEIS2chr1537242601-0.147969630.8520304
ENST00000306730ENST00000424352AVENchr1534330980-MEIS2chr1537242601-0.154448240.8455517
ENST00000306730ENST00000559561AVENchr1534330980-MEIS2chr1537242601-0.0961272640.9038727

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Fusion Genomic Features for AVEN-MEIS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AVEN-MEIS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:34330980/chr15:37242601)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MEIS2

O14770

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. {ECO:0000269|PubMed:10764806, ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:21746878}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAVENchr15:34330980chr15:37242601ENST00000306730-165_8589363.0Compositional biasNote=Ala/Gly-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397620713246_273212300.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397620713266_273212300.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397624612246_273212657.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397624612266_273212657.3333333333334Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397620713276_338212300.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397624612276_338212657.3333333333334DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000338564813340_477300471.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000340545713340_477287675.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000382766712340_477300471.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397620713340_477212300.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397624612340_477212657.3333333333334RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000424352713340_477300201.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000444725713340_477300475.6666666666667RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000557796713340_477287551.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559085612340_477287663.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559561712340_477300395.0RegionNote=Transcriptional activation domain
TgeneMEIS2chr15:34330980chr15:37242601ENST00000561208712340_477300478.0RegionNote=Transcriptional activation domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMEIS2chr15:34330980chr15:37242601ENST00000338564813195_244300471.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000338564813246_273300471.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000338564813266_273300471.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000340545713195_244287675.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000340545713246_273287675.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000340545713266_273287675.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000382766712195_244300471.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000382766712246_273300471.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000382766712266_273300471.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397620713195_244212300.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397624612195_244212657.3333333333334Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000424352713195_244300201.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000424352713246_273300201.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000424352713266_273300201.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000444725713195_244300475.6666666666667Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000444725713246_273300475.6666666666667Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000444725713266_273300475.6666666666667Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000557796713195_244287551.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000557796713246_273287551.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000557796713266_273287551.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559085612195_244287663.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559085612246_273287663.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559085612266_273287663.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559561712195_244300395.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559561712246_273300395.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559561712266_273300395.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000561208712195_244300478.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS2chr15:34330980chr15:37242601ENST00000561208712246_273300478.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS2chr15:34330980chr15:37242601ENST00000561208712266_273300478.0Compositional biasNote=Poly-Asp
TgeneMEIS2chr15:34330980chr15:37242601ENST00000338564813276_338300471.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000340545713276_338287675.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000382766712276_338300471.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000424352713276_338300201.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000444725713276_338300475.6666666666667DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000557796713276_338287551.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559085612276_338287663.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559561712276_338300395.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS2chr15:34330980chr15:37242601ENST00000561208712276_338300478.0DNA bindingHomeobox%3B TALE-type


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Fusion Gene Sequence for AVEN-MEIS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8531_8531_1_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000219869_length(transcript)=1944nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGGTTTTCT
TCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGG
GATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGC
AATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAG
TTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCC
AGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAA
TGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTT
TCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAG
AGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGA
GAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTT
AGAAGAGAAAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCA
TCCAGGAGAGACTGTGGTATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACC
TCATCACTCGAACTCCAGCTTCAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTT
ATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCA
GGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAAT
GGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAG

>8531_8531_1_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000219869_length(amino acids)=190AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMN

--------------------------------------------------------------
>8531_8531_2_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000338564_length(transcript)=3878nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGTTTGCA
GAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACA
CCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCC
TACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCA
TGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACACT
TAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACACAAATG
TGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTATAAATAT
AGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATATCCTTGT
TTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATATATTTT
AAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAA
TGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCT
TATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCT
TGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTA
TCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTT
AGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATG
AATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACATTAAAATACTTGTATGA
GGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATATTTCATTTTTGATTTTTTGTTAGGCTTTTG
CGTTTTTAATGGTTTTAGGACAAGACTGCACAATGCCAACTCTATACAGTGTTAAAAGTAGGTTTTTCCCCCCAGCAGTTGAGTATATTT
TAAACTCATCAATAATTTTTAAGGTAATCATCTATAGCCTTTCAATGTCTATTTGACCTATAAGTTCCACCAGCAGAAAACTTCTAAAGG
TACGAAACTATGTGTACATGATGAGCCAGGTTGAAAGATCCCCTTGAACATGCTCAACCTCCTTTTTAGATGCATGACGTTAAAAAATAT
ATACTTTCAGATAAAGCTTTTCATGGGCATCCTCTGCCAGAATAAAGGACTTTTCAGGGTTAATTTTACAACATAAGAAATAATGTCTGT
GCTCAAAGGTAATTTATCTGCCTGTGTTTTTCCTCTGCCTGTCTTACTACAATATTGTTGGATATGTAAATGAAAATTTACATATGGGTG
TTCATAGATAAGTAAACAACTTCTATGGAGTTTGAAATTCTGACTTTAAAAGATTACTTAATCATTAATATTTTATAAATTATATTGTGG
TATATTTTTATTTCAGACACATCCATGTGCAGGGATGCTAGTGTGATGATTTGATAACTAAACTTAAACTTTTTTCTGAAAACAAAACAA
AACAAAATGGACGGTATAATGCCATTTTCAAAATTTTATGCAACATTCCTGGAAATCTATACCATTAGCTTATTGATACTGCACAAACAA
TGTCTGCTAAAGTGTGCAAAAAGGGTGAGGCATGTCCCCTCAATTTTCAAATAAATATACTATCCTGGAATTTTTTAACTCTTAAATTTT
GAATCTTTGTTTAGAAAGAATAATGTCATATACTTTGGCTAGATATGTGATGTCAACCGGCTAAGGAAATTATTCATCATCTCTGCAAAC
TTAAACTTGGAAGAAATCCATAGTTATTATTTGGGGCTCTTCCATCTTTCCATTTCAGACAGCATTTATGGAGGTTCTATATAAATGAAC
GAGGAAATACACTTCTATTGTTTTGTGTTATATTTAGTCAGGTAGAATTTTTACAAATACATTTCAGTTTAAGTGTTGTGTTGCTGTTTA
AACATAGAAATAATGCTTCTGACACAAACTAACTTAATAGAGAAATTCAGTGCCACTTGGGAAAGAGAGATAGCTTCCCTCTCATTTTTG
CTATTCTATTTTACATGAAGTCTTTTTGTAAATTTTAAATATTTGCCTATTTTTACTTTAAATACTTTTATGTAAACTATGAAAATTCCC
CATTATAAATCAACTCTCACATCAGGTGGGAAAAAGAACCTTTTTTTCTTTCCACTCAGTAAATTCTGAAGGGTTTCCTTGGCAATTGGC
TCGTGTTTAGGATGTGTTTTATGCAATTATCAAGTTATCTCATTGAAGTTTAGAGACCAGAGCTCTCAACTCTTGGTTTTAATGAATAAA
GTCATCTCATGCTTAGTTTATTCGTCAAACCCACGTCCTATCATGTTAACTTTAACCTTCTTAAATATTTGGAGATGAATGATAATTGTA
ATATTTGTTTGCATTACCTTGCTCTCCCCCACCCCCAACCCCATGATAACACAGAGAAGTGATAGATTTGTCCAATTTTTATAATGCTTT
TTTTACACCACCCCGGAAGGCACTTGCTCCTATCTCGGGTTTACTATTTAGTGTAAAGAGTTCCGATTTGGGTATATTTAAGAAAGACTC
AGCTGTCAAAAGCAAAGAAACTGGGAATGGTGTTTTGACAACCATATAGTGTTAAAGGAAATACTGTAGTCTGAATAAAATTGCTTATGT

>8531_8531_2_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000338564_length(amino acids)=259AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPM

--------------------------------------------------------------
>8531_8531_3_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000340545_length(transcript)=2147nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTAT
GAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAG
TTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGAC
CCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGG
ACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGA
CATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTT
GACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACA
CAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTAT
AAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATAT
CCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATA
TATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTT
CAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCC
AATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCT
GAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGG
ACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTT
CATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATG
TCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACATTAAAATACTT

>8531_8531_3_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000340545_length(amino acids)=183AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQW

--------------------------------------------------------------
>8531_8531_4_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000382766_length(transcript)=2051nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGTTTGCA
GAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCCCACA
CCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGGACCCCC
TACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGACATTCA
TGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTTGACACT
TAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACACAAATG
TGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTATAAATAT
AGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATATCCTTGT
TTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATATATTTT
AAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTTCAAGAA
TGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCCAATTCT
TATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCTGAGCCT
TGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGGACTTTA
TCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTT
AGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATG
AATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACATTAAAATACTTGTATGA

>8531_8531_4_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000382766_length(amino acids)=259AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPM

--------------------------------------------------------------
>8531_8531_5_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000397620_length(transcript)=1331nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTAT
GAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAG
TTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGAC
CCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGG
ACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGA
CATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTT
GACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACA
CAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTAT

>8531_8531_5_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000397620_length(amino acids)=183AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQW

--------------------------------------------------------------
>8531_8531_6_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000397624_length(transcript)=2148nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTAT
GAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAG
TTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGAC
CCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGG
ACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGA
CATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTT
GACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACA
CAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTAT
AAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATAT
CCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATA
TATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTT
CAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCC
AATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCT
GAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGG
ACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTT
CATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATG
TCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACATTAAAATACTT

>8531_8531_6_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000397624_length(amino acids)=183AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQW

--------------------------------------------------------------
>8531_8531_7_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000424352_length(transcript)=1350nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGGTTTTCT
TCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGG
GATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGC
AATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAG
TTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCC
AGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAA
TGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTT
TCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAG
AGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGA
GAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTT

>8531_8531_7_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000424352_length(amino acids)=190AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMN

--------------------------------------------------------------
>8531_8531_8_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000444725_length(transcript)=2147nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTAT
GAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAG
TTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGAC
CCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGG
ACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGA
CATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTT
GACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACA
CAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTAT
AAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATAT
CCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATA
TATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTT
CAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCC
AATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCT
GAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCATTGAACCATAACTAGG
ACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTT
CATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATG
TCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATTTACATTAAAATACTT

>8531_8531_8_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000444725_length(amino acids)=183AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQW

--------------------------------------------------------------
>8531_8531_9_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000557796_length(transcript)=1769nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTAT
GAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGCAATCGCAAAGCAAGGGGGAAG
TTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGAC
CCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCATGATGATGCACGGAGG
ACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGGCGGACAGGTTATGGA
CATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAACTTTGACCAGATGTT
GACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACCAATGCAACAAGAACA
CAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTATAACTACTGTAGTAT
AAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGAGAAAAAAAAATATAT
CCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGGAGAGACTGTGGTATA
TATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCACTCGAACTCCAGCTT
CAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTTCGTGCTTCATAAGCC
AATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCTTCTTCCAGGAGTTCT

>8531_8531_9_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000557796_length(amino acids)=183AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQW

--------------------------------------------------------------
>8531_8531_10_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000559085_length(transcript)=1944nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGGTTTTCT
TCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGG
GATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGATGGGCAATGGCACTACATGTAACCTTCATCATGTAAAGC
AATCGCAAAGCAAGGGGGAAGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAG
TTACACTCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCC
AGCCATGATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAA
TGTTGGCGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTT
TCTGAACTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAG
AGGACCAATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGA
GAGTTATAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTT
AGAAGAGAAAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCA
TCCAGGAGAGACTGTGGTATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACC
TCATCACTCGAACTCCAGCTTCAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTT
ATAGTTCGTGCTTCATAAGCCAATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCA
GGAGCTTCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAAT
GGTCATTGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAG

>8531_8531_10_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000559085_length(amino acids)=190AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMN

--------------------------------------------------------------
>8531_8531_11_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000559561_length(transcript)=684nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGTGAGCCA
AGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGGGATCCGGCCTGCAGGACCTAT

>8531_8531_11_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000559561_length(amino acids)=183AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQW

--------------------------------------------------------------
>8531_8531_12_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000561208_length(transcript)=3896nt_BP=397nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGCATCCGTACCCTTCCGAAGAGCAGAAGAAACAGTTAGCGCAAGACACAGGACT
TACAATTCTCCAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCCATGATTGACCAGTCAAATCGAGCAGGTTTTCT
TCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTTTGTGTTGGATGGTCAGCAACACATGGG
GATCCGGCCTGCAGGTTTGCAGAGCATGCCAGGGGACTACGTTTCTCAGGGTGGTCCTATGGGAATGAGTATGGCACAGCCAAGTTACAC
TCCTCCCCAGATGACCCCACACCCTACTCAATTAAGACATGGACCCCCAATGCATTCATATTTGCCAAGCCATCCCCACCACCCAGCCAT
GATGATGCACGGAGGACCCCCTACCCACCCTGGAATGACTATGTCAGCACAGAGCCCCACAATGTTAAATTCTGTAGATCCCAATGTTGG
CGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAGGAAACACACGCAAAAACTATTTTAAGACTTTCTGAA
CTTTGACCAGATGTTGACACTTAATATGAAATTCCAGACAGCTGTGATTATTTTTTACTTTTGTCATTTTTCATCAAGCAACAGAGGACC
AATGCAACAAGAACACAAATGTGAAATCATGGGCTGACTGAGACAATTCTGTCCATGTAAAGATCCTCTGGAAAAAGACTCCGAGAGTTA
TAACTACTGTAGTATAAATATAGGAACTAAGTTAAACTTGTACATTTCTGTTGATCACGCCGTTATGTTGCCTCAAATAGTTTTAGAAGA
GAAAAAAAAATATATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTCATCAGTGAATTCACCATCCAGG
AGAGACTGTGGTATATATTTTAAACCTGTTGGGCCAATGAGAAAAGAACCACACTGGAGATCATGATGAACTTTTGGCTGAACCTCATCA
CTCGAACTCCAGCTTCAAGAATGTGTTTTCATGCCCGGCCTTTGTTCCTCCATAAATGTGTCCTTTAGTTTCAAACAGATCTTTATAGTT
CGTGCTTCATAAGCCAATTCTTATTATTATTTTTGGGGGACTCTTCTTCAAAGAGCTTGCCAATGAAGATTTAAAGACAGAGCAGGAGCT
TCTTCCAGGAGTTCTGAGCCTTGGTTGTGGACAAAACAATCTTAAGTTGGGCAGCTTTCCTCAACACAAAAAAAAGTTATTAATGGTCAT
TGAACCATAACTAGGACTTTATCAGAAACTCAAAGCTTGGGGGATAAAAAGGAGCAAGAGAATACTGTAACAAACTTCGTACAGAGTTCG
GTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGG
AATTGGTATTGTATGTCCATGAATTCTTCTTTTCTCAGCACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAATT
TACATTAAAATACTTGTATGAGGACTGTGACGTTATGTTAAAAAAAAAAAGGTGTTAAGTCACAAAAAGCGGTAATAAATATTTCATTTT
TGATTTTTTGTTAGGCTTTTGCGTTTTTAATGGTTTTAGGACAAGACTGCACAATGCCAACTCTATACAGTGTTAAAAGTAGGTTTTTCC
CCCCAGCAGTTGAGTATATTTTAAACTCATCAATAATTTTTAAGGTAATCATCTATAGCCTTTCAATGTCTATTTGACCTATAAGTTCCA
CCAGCAGAAAACTTCTAAAGGTACGAAACTATGTGTACATGATGAGCCAGGTTGAAAGATCCCCTTGAACATGCTCAACCTCCTTTTTAG
ATGCATGACGTTAAAAAATATATACTTTCAGATAAAGCTTTTCATGGGCATCCTCTGCCAGAATAAAGGACTTTTCAGGGTTAATTTTAC
AACATAAGAAATAATGTCTGTGCTCAAAGGTAATTTATCTGCCTGTGTTTTTCCTCTGCCTGTCTTACTACAATATTGTTGGATATGTAA
ATGAAAATTTACATATGGGTGTTCATAGATAAGTAAACAACTTCTATGGAGTTTGAAATTCTGACTTTAAAAGATTACTTAATCATTAAT
ATTTTATAAATTATATTGTGGTATATTTTTATTTCAGACACATCCATGTGCAGGGATGCTAGTGTGATGATTTGATAACTAAACTTAAAC
TTTTTTCTGAAAACAAAACAAAACAAAATGGACGGTATAATGCCATTTTCAAAATTTTATGCAACATTCCTGGAAATCTATACCATTAGC
TTATTGATACTGCACAAACAATGTCTGCTAAAGTGTGCAAAAAGGGTGAGGCATGTCCCCTCAATTTTCAAATAAATATACTATCCTGGA
ATTTTTTAACTCTTAAATTTTGAATCTTTGTTTAGAAAGAATAATGTCATATACTTTGGCTAGATATGTGATGTCAACCGGCTAAGGAAA
TTATTCATCATCTCTGCAAACTTAAACTTGGAAGAAATCCATAGTTATTATTTGGGGCTCTTCCATCTTTCCATTTCAGACAGCATTTAT
GGAGGTTCTATATAAATGAACGAGGAAATACACTTCTATTGTTTTGTGTTATATTTAGTCAGGTAGAATTTTTACAAATACATTTCAGTT
TAAGTGTTGTGTTGCTGTTTAAACATAGAAATAATGCTTCTGACACAAACTAACTTAATAGAGAAATTCAGTGCCACTTGGGAAAGAGAG
ATAGCTTCCCTCTCATTTTTGCTATTCTATTTTACATGAAGTCTTTTTGTAAATTTTAAATATTTGCCTATTTTTACTTTAAATACTTTT
ATGTAAACTATGAAAATTCCCCATTATAAATCAACTCTCACATCAGGTGGGAAAAAGAACCTTTTTTTCTTTCCACTCAGTAAATTCTGA
AGGGTTTCCTTGGCAATTGGCTCGTGTTTAGGATGTGTTTTATGCAATTATCAAGTTATCTCATTGAAGTTTAGAGACCAGAGCTCTCAA
CTCTTGGTTTTAATGAATAAAGTCATCTCATGCTTAGTTTATTCGTCAAACCCACGTCCTATCATGTTAACTTTAACCTTCTTAAATATT
TGGAGATGAATGATAATTGTAATATTTGTTTGCATTACCTTGCTCTCCCCCACCCCCAACCCCATGATAACACAGAGAAGTGATAGATTT
GTCCAATTTTTATAATGCTTTTTTTACACCACCCCGGAAGGCACTTGCTCCTATCTCGGGTTTACTATTTAGTGTAAAGAGTTCCGATTT
GGGTATATTTAAGAAAGACTCAGCTGTCAAAAGCAAAGAAACTGGGAATGGTGTTTTGACAACCATATAGTGTTAAAGGAAATACTGTAG

>8531_8531_12_AVEN-MEIS2_AVEN_chr15_34330980_ENST00000306730_MEIS2_chr15_37242601_ENST00000561208_length(amino acids)=266AA_BP=37
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPH
PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AVEN-MEIS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMEIS2chr15:34330980chr15:37242601ENST00000338564813299_333300.0471.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000340545713299_333287.0675.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000382766712299_333300.0471.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397620713299_333212.0300.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000397624612299_333212.0657.3333333333334DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000424352713299_333300.0201.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000444725713299_333300.0475.6666666666667DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000557796713299_333287.0551.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559085612299_333287.0663.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000559561712299_333300.0395.0DNA
TgeneMEIS2chr15:34330980chr15:37242601ENST00000561208712299_333300.0478.0DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AVEN-MEIS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AVEN-MEIS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource