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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SOX5-DTD2 (FusionGDB2 ID:85325)

Fusion Gene Summary for SOX5-DTD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SOX5-DTD2
Fusion gene ID: 85325
HgeneTgene
Gene symbol

SOX5

DTD2

Gene ID

6660

112487

Gene nameSRY-box transcription factor 5D-aminoacyl-tRNA deacylase 2
SynonymsL-SOX5|L-SOX5B|L-SOX5F|LAMSHFATD|C14orf126
Cytomap

12p12.1

14q12

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor SOX-5SRY (sex determining region Y)-box 5SRY-box 5D-aminoacyl-tRNA deacylase 2D-tyrosyl-tRNA deacylase 2 (putative)D-tyrosyl-tRNA(Tyr) deacylase 2L-alanyl-tRNA deacylaseanimalia-specifc tRNA deacylaseanimalia-specific tRNA deacylaseprobable D-tyrosyl-tRNA(Tyr) deacylase 2putative D-tyrosyl-tRNA de
Modification date2020031320200313
UniProtAcc.

Q96FN9

Ensembl transtripts involved in fusion geneENST00000309359, ENST00000381381, 
ENST00000451604, ENST00000537393, 
ENST00000541536, ENST00000545921, 
ENST00000546136, ENST00000396007, 
ENST00000441133, ENST00000536850, 
ENST00000541847, 		ENST00000310850, 
ENST00000356180, 
Fusion gene scores* DoF score19 X 15 X 10=28502 X 1 X 2=4
# samples 193
** MAII scorelog2(19/2850*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/4*10)=2.90689059560852
Context

PubMed: SOX5 [Title/Abstract] AND DTD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSOX5(23887618)-DTD2(31922550), # samples:1
Anticipated loss of major functional domain due to fusion event.SOX5-DTD2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSOX5

GO:0032332

positive regulation of chondrocyte differentiation

21401405

HgeneSOX5

GO:0061036

positive regulation of cartilage development

21401405

HgeneSOX5

GO:0071560

cellular response to transforming growth factor beta stimulus

21401405

HgeneSOX5

GO:2000741

positive regulation of mesenchymal stem cell differentiation

21401405

TgeneDTD2

GO:0106074

aminoacyl-tRNA metabolism involved in translational fidelity

29410408


check buttonFusion gene breakpoints across SOX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DTD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A27B-01ASOX5chr12

23887618

-DTD2chr14

31922550

-


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Fusion Gene ORF analysis for SOX5-DTD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000309359ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
Frame-shiftENST00000309359ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
Frame-shiftENST00000381381ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
Frame-shiftENST00000381381ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000451604ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000451604ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000537393ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000537393ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000541536ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000541536ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000545921ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000545921ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000546136ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
In-frameENST00000546136ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000396007ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000396007ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000441133ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000441133ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000536850ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000536850ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000541847ENST00000310850SOX5chr12

23887618

-DTD2chr14

31922550

-
intron-3CDSENST00000541847ENST00000356180SOX5chr12

23887618

-DTD2chr14

31922550

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000546136SOX5chr1223887618-ENST00000310850DTD2chr1431922550-326377431169388
ENST00000546136SOX5chr1223887618-ENST00000356180DTD2chr1431922550-203177431169388
ENST00000451604SOX5chr1223887618-ENST00000310850DTD2chr1431922550-3401912481307419
ENST00000451604SOX5chr1223887618-ENST00000356180DTD2chr1431922550-2169912481307419
ENST00000537393SOX5chr1223887618-ENST00000310850DTD2chr1431922550-3240751311146371
ENST00000537393SOX5chr1223887618-ENST00000356180DTD2chr1431922550-2008751311146371
ENST00000541536SOX5chr1223887618-ENST00000310850DTD2chr1431922550-326477541170388
ENST00000541536SOX5chr1223887618-ENST00000356180DTD2chr1431922550-203277541170388
ENST00000545921SOX5chr1223887618-ENST00000310850DTD2chr1431922550-34259361561331391
ENST00000545921SOX5chr1223887618-ENST00000356180DTD2chr1431922550-21939361561331391

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000546136ENST00000310850SOX5chr1223887618-DTD2chr1431922550-0.0006002810.99939966
ENST00000546136ENST00000356180SOX5chr1223887618-DTD2chr1431922550-0.0023545790.99764544
ENST00000451604ENST00000310850SOX5chr1223887618-DTD2chr1431922550-0.0005969370.9994031
ENST00000451604ENST00000356180SOX5chr1223887618-DTD2chr1431922550-0.0021130640.99788696
ENST00000537393ENST00000310850SOX5chr1223887618-DTD2chr1431922550-0.0004534220.9995466
ENST00000537393ENST00000356180SOX5chr1223887618-DTD2chr1431922550-0.0018163360.99818367
ENST00000541536ENST00000310850SOX5chr1223887618-DTD2chr1431922550-0.0006010.99939895
ENST00000541536ENST00000356180SOX5chr1223887618-DTD2chr1431922550-0.0023704090.9976295
ENST00000545921ENST00000310850SOX5chr1223887618-DTD2chr1431922550-0.0005823560.99941766
ENST00000545921ENST00000356180SOX5chr1223887618-DTD2chr1431922550-0.0018649280.9981351

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Fusion Genomic Features for SOX5-DTD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SOX5-DTD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:23887618/chr14:31922550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DTD2

Q96FN9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity). {ECO:0000250|UniProtKB:Q8BHA3, ECO:0000269|PubMed:29410408}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDTD2chr12:23887618chr14:31922550ENST0000031085003160_16137169.0MotifGly-transPro motif%2C allows the protein to recognize chirality of D-amino acids
TgeneDTD2chr12:23887618chr14:31922550ENST0000035618005160_16137243.66666666666666MotifGly-transPro motif%2C allows the protein to recognize chirality of D-amino acids

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOX5chr12:23887618chr14:31922550ENST00000309359-615193_274257751.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000309359-615448_515257751.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000381381-613193_274257643.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000381381-613448_515257643.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000396007-17193_2740378.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000396007-17448_5150378.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000451604-615193_274270764.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000451604-615448_515270764.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000541536-512193_274257643.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000541536-512448_515257643.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000545921-615193_274260754.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000545921-615448_515260754.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000546136-514193_274257751.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000546136-514448_515257751.0Coiled coilOntology_term=ECO:0000255
HgeneSOX5chr12:23887618chr14:31922550ENST00000309359-615556_624257751.0DNA bindingHMG box
HgeneSOX5chr12:23887618chr14:31922550ENST00000381381-613556_624257643.0DNA bindingHMG box
HgeneSOX5chr12:23887618chr14:31922550ENST00000396007-17556_6240378.0DNA bindingHMG box
HgeneSOX5chr12:23887618chr14:31922550ENST00000451604-615556_624270764.0DNA bindingHMG box
HgeneSOX5chr12:23887618chr14:31922550ENST00000541536-512556_624257643.0DNA bindingHMG box
HgeneSOX5chr12:23887618chr14:31922550ENST00000545921-615556_624260754.0DNA bindingHMG box
HgeneSOX5chr12:23887618chr14:31922550ENST00000546136-514556_624257751.0DNA bindingHMG box


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Fusion Gene Sequence for SOX5-DTD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85325_85325_1_SOX5-DTD2_SOX5_chr12_23887618_ENST00000451604_DTD2_chr14_31922550_ENST00000310850_length(transcript)=3401nt_BP=912nt
GAGAAAATCAATTGGTTTAGAAGGTTTGGACTCACTTGACAGGTTCAGTTGGAGACGATCATAGGTGGCTGCTGTGACAAAGGGAAATTG
TGCTTTTCCAGCATGCTTACTGACCCTGATTTACCTCAGGAGTTTGAAAGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCA
GATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTG
AGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAG
CACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGT
GGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTG
AAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAG
CTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATC
AACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAG
CAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAG
CAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTCAAGGGAGCTGATAAAGAACTTCTTCCCAAAATGGTTAATACA
CTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCTATATTGGATCTACCTGGCAACATTCTTATTATCCCTCAAGCT
ACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAACTCTGGAAAAGAAGAAGGGTTTGAACTTTACTCTCAATTTGTG
ACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCTAGGGTTGTAGTGGAACATGGCACTTATGGGAACAGGCAGGTG
TTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGAAAATGAAAAACTAGTTTCTATAGCTGTTTTCTGGTATGAAAT
GATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTAATCTTCAGCATTTTTAGACAGGAAAATCTTGGGTTTCATATA
TAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTCTGGATCTCAGTCACCTTTTGTCCTACATTCCTCTACCCTTCT
ACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGGAAATGTTCTTAATTGTTTTTTTGTTTTTGTTTTTTTTTTGAG
ATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCTGGATTCAAGCGATTCTCCT
GCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCATGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACC
GTGCTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGACTACAGGCATGAGCCACCGT
GCCCGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGTATTTTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCT
TATACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGTATTAAAATTAGGTAAACTTCAGCACAACCCAATTATAACTTTGTT
AATTTTGTTTACTATTTCAGTTTTCTGTATTTCCATATGTAAGTCACCATTTCTTTTAATAATATGCATGAAAATGTAATATAGGGCCAA
ATGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCAGGAGTTTGCGACCAGCCTGGGCA
GAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTAATATAGAAGGGTTATTGTGTGTTATATTACTTTCCAG
GGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACAAAGTATAAGGGTTTAAAAGTTGTTTTTATTAAACATA
CTATATAAATGGGTTAATGGTCTATTTTTCAGTTTTTACCAAAATCATGTGTCTCACTTTTTGTCTTCGCTTTTTAAAGAACTGGTTCAT
GAAATTAGTGTTAGTTCATAAATTGTTTAAGAAGTTCCTTTTCCATTGAATTAGATTGCTGTAAAAGGGAGAAAAAGGGAAGCTTCCCAT
AAGAATAGTTTGAAAACAAATTGACTTGTTCATTTCCATATTATCTGCTTGATGATATGGAGCCAGTGTCAATTTTTCTGTTAGTGAATG
TTTTGGACTAGATGTTCCCGTCCCCAAAATTTATATGTTGAAGCCCTTATTAATGTGATGGTATCTGGAGATGGGGCTCCTCCAACCATC
CCATCCTGGAACATATAAGCCAGAAAGAAAGTAGTCTCCAGAAACAGACCATGCTGACACCTTGAGTTTGAACTTCTAATCACCAGAACT
GTGAGGAAATAAATTTCTGGTGTTTAAACCACCCAGTCCTATGGTATTTTGTTAGGGCAGTCTGAGCTACGACAGTGATATAAGATAGAC
AGCTAGTAAGGTAAACTTTTCAAAGGCAAGAGAGGAAGATATACAAGAAATTGAAAGAATAATTAAGTCAGTAAGAGGTAATATTCAGTT
TTGGCAAACTCCTCTGACTTGAGTTGAAAATACTTTTTTTTTTTAAGAGTAAAAACCAAATAACTAATTCTAATTGGCAAAAAAAGGTAA
ATAAATAAACATCCTAAGTAGCTGCTGAAATTTCCGTTGTGTCTTATAGTTTCTTTAGGTCTGTGTTCCTAAGATGCTTAAAATTTTTAT
CATGAAAAATCCTATTTTCTCTATACCCTTCCTGTACTGTTCTATTTTGGAACCAGAGAATCAATAACTGGCTTGGTAATGAGCTCATTG

>85325_85325_1_SOX5-DTD2_SOX5_chr12_23887618_ENST00000451604_DTD2_chr14_31922550_ENST00000310850_length(amino acids)=419AA_BP=288
METIIGGCCDKGKLCFSSMLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSL
LTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEET
PSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQ
QQLLQQQHKINLLQQQIQVQRGLVIYVCFFKGADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSN

--------------------------------------------------------------
>85325_85325_2_SOX5-DTD2_SOX5_chr12_23887618_ENST00000451604_DTD2_chr14_31922550_ENST00000356180_length(transcript)=2169nt_BP=912nt
GAGAAAATCAATTGGTTTAGAAGGTTTGGACTCACTTGACAGGTTCAGTTGGAGACGATCATAGGTGGCTGCTGTGACAAAGGGAAATTG
TGCTTTTCCAGCATGCTTACTGACCCTGATTTACCTCAGGAGTTTGAAAGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCA
GATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTG
AGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAG
CACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGT
GGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTG
AAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAG
CTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATC
AACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAG
CAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAG
CAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTCAAGGGAGCTGATAAAGAACTTCTTCCCAAAATGGTTAATACA
CTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCTATATTGGATCTACCTGGCAACATTCTTATTATCCCTCAAGCT
ACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAACTCTGGAAAAGAAGAAGGGTTTGAACTTTACTCTCAATTTGTG
ACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCTAGGGTTGTAGTGGAACATGGCACTTATGGGAACAGGCAGGTG
TTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGAAAATGAAAAACTAGTTTCTATAGCTGTTTTCTGGTATGAAAT
GATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTAATCTTCAGCATTTTTAGACAGGAAAATCTTGGGTTTCATATA
TAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTCTGGATCTCAGTCACCTTTTGTCCTACATTCCTCTACCCTTCT
ACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGGAAATGTTCTTAATTGTTTTTTTGTTTTTGTTTTTTTTTTGAG
ATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCTGGATTCAAGCGATTCTCCT
GCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGAGCCACCGTGCCCGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGT
ATTTTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCTTATACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGT
ATTAAAATTAGGTAAACTTCAGCACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCAGGAGTTTGCGACCAGCCTGGGCAGAATAG
CAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTAATATAGAAGGGTTATTGTGTGTTATATTACTTTCCAGGGACAT
TCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACAAAGTATAAGGGTTTAAAAGTTGTTTTTATTAAACATACTATAT

>85325_85325_2_SOX5-DTD2_SOX5_chr12_23887618_ENST00000451604_DTD2_chr14_31922550_ENST00000356180_length(amino acids)=419AA_BP=288
METIIGGCCDKGKLCFSSMLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSL
LTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEET
PSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQ
QQLLQQQHKINLLQQQIQVQRGLVIYVCFFKGADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSN

--------------------------------------------------------------
>85325_85325_3_SOX5-DTD2_SOX5_chr12_23887618_ENST00000537393_DTD2_chr14_31922550_ENST00000310850_length(transcript)=3240nt_BP=751nt
GATCATAGGTGGCTGCTGTGACAAAGGGAAATTGTGCTTTTCCAGCATGCTTACTGACCCTGATTTACCTCAGGAGTTTGAAAGGATGTC
TTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGA
CGGGCTCCCAGCCTTTCACCTTCCCTTGCATGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACC
TCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGC
TGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTC
AAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAG
GCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCA
GATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACA
CAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTCAAGGGAGCTGATAAAGAACTTCT
TCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCTATATTGGATCTACCTGGCAACAT
TCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAACTCTGGAAAAGAAGAAGGGTTTGA
ACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCTAGGGTTGTAGTGGAACATGGCAC
TTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGAAAATGAAAAACTAGTTTCTATAG
CTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTAATCTTCAGCATTTTTAGACAGGA
AAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTCTGGATCTCAGTCACCTTTTGTCC
TACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGGAAATGTTCTTAATTGTTTTTTTG
TTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCT
GGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCATGCCACCATGCCCAGCTAATTTTTTTGTATTTTTA
GTAGAGATGGGGTTTCACCGTGCTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGAC
TACAGGCATGAGCCACCGTGCCCGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGTATTTTGCAATGAAGAAATTCATGCAA
ACAAGAAAAACACATTTCTTATACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGTATTAAAATTAGGTAAACTTCAGCACA
ACCCAATTATAACTTTGTTAATTTTGTTTACTATTTCAGTTTTCTGTATTTCCATATGTAAGTCACCATTTCTTTTAATAATATGCATGA
AAATGTAATATAGGGCCAAATGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCAGGAG
TTTGCGACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTAATATAGAAGGGTTATTGT
GTGTTATATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACAAAGTATAAGGGTTTAAAA
GTTGTTTTTATTAAACATACTATATAAATGGGTTAATGGTCTATTTTTCAGTTTTTACCAAAATCATGTGTCTCACTTTTTGTCTTCGCT
TTTTAAAGAACTGGTTCATGAAATTAGTGTTAGTTCATAAATTGTTTAAGAAGTTCCTTTTCCATTGAATTAGATTGCTGTAAAAGGGAG
AAAAAGGGAAGCTTCCCATAAGAATAGTTTGAAAACAAATTGACTTGTTCATTTCCATATTATCTGCTTGATGATATGGAGCCAGTGTCA
ATTTTTCTGTTAGTGAATGTTTTGGACTAGATGTTCCCGTCCCCAAAATTTATATGTTGAAGCCCTTATTAATGTGATGGTATCTGGAGA
TGGGGCTCCTCCAACCATCCCATCCTGGAACATATAAGCCAGAAAGAAAGTAGTCTCCAGAAACAGACCATGCTGACACCTTGAGTTTGA
ACTTCTAATCACCAGAACTGTGAGGAAATAAATTTCTGGTGTTTAAACCACCCAGTCCTATGGTATTTTGTTAGGGCAGTCTGAGCTACG
ACAGTGATATAAGATAGACAGCTAGTAAGGTAAACTTTTCAAAGGCAAGAGAGGAAGATATACAAGAAATTGAAAGAATAATTAAGTCAG
TAAGAGGTAATATTCAGTTTTGGCAAACTCCTCTGACTTGAGTTGAAAATACTTTTTTTTTTTAAGAGTAAAAACCAAATAACTAATTCT
AATTGGCAAAAAAAGGTAAATAAATAAACATCCTAAGTAGCTGCTGAAATTTCCGTTGTGTCTTATAGTTTCTTTAGGTCTGTGTTCCTA
AGATGCTTAAAATTTTTATCATGAAAAATCCTATTTTCTCTATACCCTTCCTGTACTGTTCTATTTTGGAACCAGAGAATCAATAACTGG
CTTGGTAATGAGCTCATTGTCCTTAACTTTTGCTTTATTGATTCACAATACACTTACTGAAATGTAATAAACTATTCATAAACTTGCAAA

>85325_85325_3_SOX5-DTD2_SOX5_chr12_23887618_ENST00000537393_DTD2_chr14_31922550_ENST00000310850_length(amino acids)=371AA_BP=240
MCFSSMLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHEVDGNKVMSSFAPHNSSTSPQKAEEGGRQS
GESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLT
SLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVCFFKGADKELLPKMVNTLLNV
KLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEARVVVEHGTYGNRQVLKLD

--------------------------------------------------------------
>85325_85325_4_SOX5-DTD2_SOX5_chr12_23887618_ENST00000537393_DTD2_chr14_31922550_ENST00000356180_length(transcript)=2008nt_BP=751nt
GATCATAGGTGGCTGCTGTGACAAAGGGAAATTGTGCTTTTCCAGCATGCTTACTGACCCTGATTTACCTCAGGAGTTTGAAAGGATGTC
TTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGA
CGGGCTCCCAGCCTTTCACCTTCCCTTGCATGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACC
TCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGC
TGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTC
AAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAG
GCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCA
GATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACA
CAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTCAAGGGAGCTGATAAAGAACTTCT
TCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCTATATTGGATCTACCTGGCAACAT
TCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAACTCTGGAAAAGAAGAAGGGTTTGA
ACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCTAGGGTTGTAGTGGAACATGGCAC
TTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGAAAATGAAAAACTAGTTTCTATAG
CTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTAATCTTCAGCATTTTTAGACAGGA
AAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTCTGGATCTCAGTCACCTTTTGTCC
TACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGGAAATGTTCTTAATTGTTTTTTTG
TTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCACCTCCT
GGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGAGCCACCGTGCCCGGCCTCTTAGTTGTTTTTTAAA
AATTATGTACATTTTAAGTATTTTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCTTATACCATCAAATTTGTGTAGCATGT
AATAAAAATAACTATTTGTATTAAAATTAGGTAAACTTCAGCACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCAGGAGTTTGCG
ACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTAATATAGAAGGGTTATTGTGTGTTA
TATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACAAAGTATAAGGGTTTAAAAGTTGTT

>85325_85325_4_SOX5-DTD2_SOX5_chr12_23887618_ENST00000537393_DTD2_chr14_31922550_ENST00000356180_length(amino acids)=371AA_BP=240
MCFSSMLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHEVDGNKVMSSFAPHNSSTSPQKAEEGGRQS
GESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLT
SLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVCFFKGADKELLPKMVNTLLNV
KLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEARVVVEHGTYGNRQVLKLD

--------------------------------------------------------------
>85325_85325_5_SOX5-DTD2_SOX5_chr12_23887618_ENST00000541536_DTD2_chr14_31922550_ENST00000310850_length(transcript)=3264nt_BP=775nt
CAGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGA
GGAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCT
GCTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGC
CCCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCC
TGAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAAC
CCCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCC
CGAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGA
GCAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCA
GCAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTT
CAAGGGAGCTGATAAAGAACTTCTTCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTC
TATATTGGATCTACCTGGCAACATTCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAA
CTCTGGAAAAGAAGAAGGGTTTGAACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGC
TAGGGTTGTAGTGGAACATGGCACTTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTG
AAAATGAAAAACTAGTTTCTATAGCTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACT
AATCTTCAGCATTTTTAGACAGGAAAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACT
CTGGATCTCAGTCACCTTTTGTCCTACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAG
GAAATGTTCTTAATTGTTTTTTTGTTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTC
GGCTCACTGCAACCTCCACCTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCATGCCACCATGC
CCAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGCTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCAC
CTCGGCCTCCCAAAGTGCTGGGACTACAGGCATGAGCCACCGTGCCCGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGTAT
TTTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCTTATACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGTAT
TAAAATTAGGTAAACTTCAGCACAACCCAATTATAACTTTGTTAATTTTGTTTACTATTTCAGTTTTCTGTATTTCCATATGTAAGTCAC
CATTTCTTTTAATAATATGCATGAAAATGTAATATAGGGCCAAATGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGT
GGGAGGATCACTTGAGCCCAGGAGTTTGCGACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATA
TATGTAATATAGAAGGGTTATTGTGTGTTATATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATA
AGAACAAAGTATAAGGGTTTAAAAGTTGTTTTTATTAAACATACTATATAAATGGGTTAATGGTCTATTTTTCAGTTTTTACCAAAATCA
TGTGTCTCACTTTTTGTCTTCGCTTTTTAAAGAACTGGTTCATGAAATTAGTGTTAGTTCATAAATTGTTTAAGAAGTTCCTTTTCCATT
GAATTAGATTGCTGTAAAAGGGAGAAAAAGGGAAGCTTCCCATAAGAATAGTTTGAAAACAAATTGACTTGTTCATTTCCATATTATCTG
CTTGATGATATGGAGCCAGTGTCAATTTTTCTGTTAGTGAATGTTTTGGACTAGATGTTCCCGTCCCCAAAATTTATATGTTGAAGCCCT
TATTAATGTGATGGTATCTGGAGATGGGGCTCCTCCAACCATCCCATCCTGGAACATATAAGCCAGAAAGAAAGTAGTCTCCAGAAACAG
ACCATGCTGACACCTTGAGTTTGAACTTCTAATCACCAGAACTGTGAGGAAATAAATTTCTGGTGTTTAAACCACCCAGTCCTATGGTAT
TTTGTTAGGGCAGTCTGAGCTACGACAGTGATATAAGATAGACAGCTAGTAAGGTAAACTTTTCAAAGGCAAGAGAGGAAGATATACAAG
AAATTGAAAGAATAATTAAGTCAGTAAGAGGTAATATTCAGTTTTGGCAAACTCCTCTGACTTGAGTTGAAAATACTTTTTTTTTTTAAG
AGTAAAAACCAAATAACTAATTCTAATTGGCAAAAAAAGGTAAATAAATAAACATCCTAAGTAGCTGCTGAAATTTCCGTTGTGTCTTAT
AGTTTCTTTAGGTCTGTGTTCCTAAGATGCTTAAAATTTTTATCATGAAAAATCCTATTTTCTCTATACCCTTCCTGTACTGTTCTATTT
TGGAACCAGAGAATCAATAACTGGCTTGGTAATGAGCTCATTGTCCTTAACTTTTGCTTTATTGATTCACAATACACTTACTGAAATGTA

>85325_85325_5_SOX5-DTD2_SOX5_chr12_23887618_ENST00000541536_DTD2_chr14_31922550_ENST00000310850_length(amino acids)=388AA_BP=257
MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAP
HNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPE
SLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVCFFK
GADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEAR

--------------------------------------------------------------
>85325_85325_6_SOX5-DTD2_SOX5_chr12_23887618_ENST00000541536_DTD2_chr14_31922550_ENST00000356180_length(transcript)=2032nt_BP=775nt
CAGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGA
GGAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCT
GCTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGC
CCCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCC
TGAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAAC
CCCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCC
CGAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGA
GCAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCA
GCAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTT
CAAGGGAGCTGATAAAGAACTTCTTCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTC
TATATTGGATCTACCTGGCAACATTCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAA
CTCTGGAAAAGAAGAAGGGTTTGAACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGC
TAGGGTTGTAGTGGAACATGGCACTTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTG
AAAATGAAAAACTAGTTTCTATAGCTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACT
AATCTTCAGCATTTTTAGACAGGAAAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACT
CTGGATCTCAGTCACCTTTTGTCCTACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAG
GAAATGTTCTTAATTGTTTTTTTGTTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTC
GGCTCACTGCAACCTCCACCTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGAGCCACCGTGC
CCGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGTATTTTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCTTA
TACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGTATTAAAATTAGGTAAACTTCAGCACTTTGGGAGGCCGAGGTGGGAGG
ATCACTTGAGCCCAGGAGTTTGCGACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTA
ATATAGAAGGGTTATTGTGTGTTATATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACA

>85325_85325_6_SOX5-DTD2_SOX5_chr12_23887618_ENST00000541536_DTD2_chr14_31922550_ENST00000356180_length(amino acids)=388AA_BP=257
MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAP
HNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPE
SLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVCFFK
GADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEAR

--------------------------------------------------------------
>85325_85325_7_SOX5-DTD2_SOX5_chr12_23887618_ENST00000545921_DTD2_chr14_31922550_ENST00000310850_length(transcript)=3425nt_BP=936nt
AGTAGGAGTGGAGAGCGTGCGTGAGTGAGTGTGTGTGTGTGTGTGTGTGTGTGTGCATGCGTGTGTGAAGAATGCACACTATCTCCTGTT
GGTAAGTGTGTGCTTACTCCCTGACCAGATGCTGCGGTGCACGGGGCAGCCACCATCTCTGCATGCATGTCTGTGATGTCTTCCAAGCGA
CCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCA
GCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGT
GGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACC
TCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGT
TTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTA
CTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAA
GAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCC
TCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAA
CAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTCAAGGGAGCTGATAAAGAA
CTTCTTCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCTATATTGGATCTACCTGGC
AACATTCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAACTCTGGAAAAGAAGAAGGG
TTTGAACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCTAGGGTTGTAGTGGAACAT
GGCACTTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGAAAATGAAAAACTAGTTTC
TATAGCTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTAATCTTCAGCATTTTTAGA
CAGGAAAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTCTGGATCTCAGTCACCTTT
TGTCCTACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGGAAATGTTCTTAATTGTTT
TTTTGTTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCAC
CTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCATGCCACCATGCCCAGCTAATTTTTTTGTAT
TTTTAGTAGAGATGGGGTTTCACCGTGCTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCT
GGGACTACAGGCATGAGCCACCGTGCCCGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGTATTTTGCAATGAAGAAATTCA
TGCAAACAAGAAAAACACATTTCTTATACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGTATTAAAATTAGGTAAACTTCA
GCACAACCCAATTATAACTTTGTTAATTTTGTTTACTATTTCAGTTTTCTGTATTTCCATATGTAAGTCACCATTTCTTTTAATAATATG
CATGAAAATGTAATATAGGGCCAAATGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCC
AGGAGTTTGCGACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTAATATAGAAGGGTT
ATTGTGTGTTATATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACAAAGTATAAGGGTT
TAAAAGTTGTTTTTATTAAACATACTATATAAATGGGTTAATGGTCTATTTTTCAGTTTTTACCAAAATCATGTGTCTCACTTTTTGTCT
TCGCTTTTTAAAGAACTGGTTCATGAAATTAGTGTTAGTTCATAAATTGTTTAAGAAGTTCCTTTTCCATTGAATTAGATTGCTGTAAAA
GGGAGAAAAAGGGAAGCTTCCCATAAGAATAGTTTGAAAACAAATTGACTTGTTCATTTCCATATTATCTGCTTGATGATATGGAGCCAG
TGTCAATTTTTCTGTTAGTGAATGTTTTGGACTAGATGTTCCCGTCCCCAAAATTTATATGTTGAAGCCCTTATTAATGTGATGGTATCT
GGAGATGGGGCTCCTCCAACCATCCCATCCTGGAACATATAAGCCAGAAAGAAAGTAGTCTCCAGAAACAGACCATGCTGACACCTTGAG
TTTGAACTTCTAATCACCAGAACTGTGAGGAAATAAATTTCTGGTGTTTAAACCACCCAGTCCTATGGTATTTTGTTAGGGCAGTCTGAG
CTACGACAGTGATATAAGATAGACAGCTAGTAAGGTAAACTTTTCAAAGGCAAGAGAGGAAGATATACAAGAAATTGAAAGAATAATTAA
GTCAGTAAGAGGTAATATTCAGTTTTGGCAAACTCCTCTGACTTGAGTTGAAAATACTTTTTTTTTTTAAGAGTAAAAACCAAATAACTA
ATTCTAATTGGCAAAAAAAGGTAAATAAATAAACATCCTAAGTAGCTGCTGAAATTTCCGTTGTGTCTTATAGTTTCTTTAGGTCTGTGT
TCCTAAGATGCTTAAAATTTTTATCATGAAAAATCCTATTTTCTCTATACCCTTCCTGTACTGTTCTATTTTGGAACCAGAGAATCAATA
ACTGGCTTGGTAATGAGCTCATTGTCCTTAACTTTTGCTTTATTGATTCACAATACACTTACTGAAATGTAATAAACTATTCATAAACTT

>85325_85325_7_SOX5-DTD2_SOX5_chr12_23887618_ENST00000545921_DTD2_chr14_31922550_ENST00000310850_length(amino acids)=391AA_BP=260
MSVMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSS
FAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKG
TPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVC
FFKGADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCA

--------------------------------------------------------------
>85325_85325_8_SOX5-DTD2_SOX5_chr12_23887618_ENST00000545921_DTD2_chr14_31922550_ENST00000356180_length(transcript)=2193nt_BP=936nt
AGTAGGAGTGGAGAGCGTGCGTGAGTGAGTGTGTGTGTGTGTGTGTGTGTGTGTGCATGCGTGTGTGAAGAATGCACACTATCTCCTGTT
GGTAAGTGTGTGCTTACTCCCTGACCAGATGCTGCGGTGCACGGGGCAGCCACCATCTCTGCATGCATGTCTGTGATGTCTTCCAAGCGA
CCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCA
GCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGT
GGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACC
TCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGT
TTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTA
CTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAA
GAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCC
TCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAA
CAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTCAAGGGAGCTGATAAAGAA
CTTCTTCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCTATATTGGATCTACCTGGC
AACATTCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAACTCTGGAAAAGAAGAAGGG
TTTGAACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCTAGGGTTGTAGTGGAACAT
GGCACTTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGAAAATGAAAAACTAGTTTC
TATAGCTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTAATCTTCAGCATTTTTAGA
CAGGAAAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTCTGGATCTCAGTCACCTTT
TGTCCTACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGGAAATGTTCTTAATTGTTT
TTTTGTTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCCAC
CTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGAGCCACCGTGCCCGGCCTCTTAGTTGTTTT
TTAAAAATTATGTACATTTTAAGTATTTTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCTTATACCATCAAATTTGTGTAG
CATGTAATAAAAATAACTATTTGTATTAAAATTAGGTAAACTTCAGCACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCAGGAGT
TTGCGACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTAATATAGAAGGGTTATTGTG
TGTTATATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACAAAGTATAAGGGTTTAAAAG

>85325_85325_8_SOX5-DTD2_SOX5_chr12_23887618_ENST00000545921_DTD2_chr14_31922550_ENST00000356180_length(amino acids)=391AA_BP=260
MSVMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSS
FAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKG
TPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVC
FFKGADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCA

--------------------------------------------------------------
>85325_85325_9_SOX5-DTD2_SOX5_chr12_23887618_ENST00000546136_DTD2_chr14_31922550_ENST00000310850_length(transcript)=3263nt_BP=774nt
AGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAG
GAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTG
CTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCC
CCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCT
GAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACC
CCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCC
GAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAG
CAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAG
CAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTC
AAGGGAGCTGATAAAGAACTTCTTCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCT
ATATTGGATCTACCTGGCAACATTCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAAC
TCTGGAAAAGAAGAAGGGTTTGAACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCT
AGGGTTGTAGTGGAACATGGCACTTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGA
AAATGAAAAACTAGTTTCTATAGCTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTA
ATCTTCAGCATTTTTAGACAGGAAAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTC
TGGATCTCAGTCACCTTTTGTCCTACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGG
AAATGTTCTTAATTGTTTTTTTGTTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCG
GCTCACTGCAACCTCCACCTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCATGCCACCATGCC
CAGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGCTGGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACC
TCGGCCTCCCAAAGTGCTGGGACTACAGGCATGAGCCACCGTGCCCGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGTATT
TTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCTTATACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGTATT
AAAATTAGGTAAACTTCAGCACAACCCAATTATAACTTTGTTAATTTTGTTTACTATTTCAGTTTTCTGTATTTCCATATGTAAGTCACC
ATTTCTTTTAATAATATGCATGAAAATGTAATATAGGGCCAAATGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGTG
GGAGGATCACTTGAGCCCAGGAGTTTGCGACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATAT
ATGTAATATAGAAGGGTTATTGTGTGTTATATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAA
GAACAAAGTATAAGGGTTTAAAAGTTGTTTTTATTAAACATACTATATAAATGGGTTAATGGTCTATTTTTCAGTTTTTACCAAAATCAT
GTGTCTCACTTTTTGTCTTCGCTTTTTAAAGAACTGGTTCATGAAATTAGTGTTAGTTCATAAATTGTTTAAGAAGTTCCTTTTCCATTG
AATTAGATTGCTGTAAAAGGGAGAAAAAGGGAAGCTTCCCATAAGAATAGTTTGAAAACAAATTGACTTGTTCATTTCCATATTATCTGC
TTGATGATATGGAGCCAGTGTCAATTTTTCTGTTAGTGAATGTTTTGGACTAGATGTTCCCGTCCCCAAAATTTATATGTTGAAGCCCTT
ATTAATGTGATGGTATCTGGAGATGGGGCTCCTCCAACCATCCCATCCTGGAACATATAAGCCAGAAAGAAAGTAGTCTCCAGAAACAGA
CCATGCTGACACCTTGAGTTTGAACTTCTAATCACCAGAACTGTGAGGAAATAAATTTCTGGTGTTTAAACCACCCAGTCCTATGGTATT
TTGTTAGGGCAGTCTGAGCTACGACAGTGATATAAGATAGACAGCTAGTAAGGTAAACTTTTCAAAGGCAAGAGAGGAAGATATACAAGA
AATTGAAAGAATAATTAAGTCAGTAAGAGGTAATATTCAGTTTTGGCAAACTCCTCTGACTTGAGTTGAAAATACTTTTTTTTTTTAAGA
GTAAAAACCAAATAACTAATTCTAATTGGCAAAAAAAGGTAAATAAATAAACATCCTAAGTAGCTGCTGAAATTTCCGTTGTGTCTTATA
GTTTCTTTAGGTCTGTGTTCCTAAGATGCTTAAAATTTTTATCATGAAAAATCCTATTTTCTCTATACCCTTCCTGTACTGTTCTATTTT
GGAACCAGAGAATCAATAACTGGCTTGGTAATGAGCTCATTGTCCTTAACTTTTGCTTTATTGATTCACAATACACTTACTGAAATGTAA

>85325_85325_9_SOX5-DTD2_SOX5_chr12_23887618_ENST00000546136_DTD2_chr14_31922550_ENST00000310850_length(amino acids)=388AA_BP=257
MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAP
HNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPE
SLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVCFFK
GADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEAR

--------------------------------------------------------------
>85325_85325_10_SOX5-DTD2_SOX5_chr12_23887618_ENST00000546136_DTD2_chr14_31922550_ENST00000356180_length(transcript)=2031nt_BP=774nt
AGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAG
GAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTG
CTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCC
CCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCT
GAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACC
CCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCC
GAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAG
CAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAG
CAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTCCAAAGAGGACTGGTGATCTACGTGTGCTTTTTC
AAGGGAGCTGATAAAGAACTTCTTCCCAAAATGGTTAATACACTGTTAAATGTGAAATTAAGTGAGACAGAAAATGGCAAGCATGTCTCT
ATATTGGATCTACCTGGCAACATTCTTATTATCCCTCAAGCTACCCTTGGAGGAAGACTAAAAGGAAGAAACATGCAATATCACTCTAAC
TCTGGAAAAGAAGAAGGGTTTGAACTTTACTCTCAATTTGTGACTCTATGTGAAAAAGAAGTAGCTGCTAATAGCAAGTGTGCTGAAGCT
AGGGTTGTAGTGGAACATGGCACTTATGGGAACAGGCAGGTGTTAAAGCTGGACACCAACGGACCATTCACACACTTAATTGAGTTTTGA
AAATGAAAAACTAGTTTCTATAGCTGTTTTCTGGTATGAAATGATCTAAAGTATAATTAGATTTTCTTCCCCTTAATCTTGAATATACTA
ATCTTCAGCATTTTTAGACAGGAAAATCTTGGGTTTCATATATAACTCTGCACCTGCTAATTGGATGACTTTGCCAAGTCACCTAAACTC
TGGATCTCAGTCACCTTTTGTCCTACATTCCTCTACCCTTCTACTTGAAAATTTGAAATATGCTGTCTATTCACTTCATAGTCATTAAGG
AAATGTTCTTAATTGTTTTTTTGTTTTTGTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCAGACTGGAGTGCAGTGGCGCAATCTCG
GCTCACTGCAACCTCCACCTCCTGGATTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGAGCCACCGTGCC
CGGCCTCTTAGTTGTTTTTTAAAAATTATGTACATTTTAAGTATTTTGCAATGAAGAAATTCATGCAAACAAGAAAAACACATTTCTTAT
ACCATCAAATTTGTGTAGCATGTAATAAAAATAACTATTTGTATTAAAATTAGGTAAACTTCAGCACTTTGGGAGGCCGAGGTGGGAGGA
TCACTTGAGCCCAGGAGTTTGCGACCAGCCTGGGCAGAATAGCAAGACCCAGTCTCTAACATATACATATACATATAGATATATATGTAA
TATAGAAGGGTTATTGTGTGTTATATTACTTTCCAGGGACATTCAAATGTTTTACATTACTTTAAGAATCTTTACTTGATATAAGAACAA

>85325_85325_10_SOX5-DTD2_SOX5_chr12_23887618_ENST00000546136_DTD2_chr14_31922550_ENST00000356180_length(amino acids)=388AA_BP=257
MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAP
HNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPE
SLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQRGLVIYVCFFK
GADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEAR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SOX5-DTD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SOX5-DTD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SOX5-DTD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource