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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SP4-GPNMB (FusionGDB2 ID:85407)

Fusion Gene Summary for SP4-GPNMB

check button Fusion gene summary
Fusion gene informationFusion gene name: SP4-GPNMB
Fusion gene ID: 85407
HgeneTgene
Gene symbol

SP4

GPNMB

Gene ID

6671

10457

Gene nameSp4 transcription factorglycoprotein nmb
SynonymsHF1B|SPR-1HGFIN|NMB|PLCA3
Cytomap

7p15.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor Sp4transmembrane glycoprotein NMBglycoprotein (transmembrane) nmbglycoprotein nmb-like proteinglycoprotein nonmetastatic melanoma protein Bhematopoietic growth factor inducible neurokinin-1hematopoietic growth factor inducible neurokinin-1 typeosteoact
Modification date2020031320200315
UniProtAcc.

Q14956

Ensembl transtripts involved in fusion geneENST00000222584, ENST00000478451, 
ENST00000409458, ENST00000453162, 
ENST00000539136, ENST00000258733, 
ENST00000381990, 
Fusion gene scores* DoF score2 X 3 X 2=127 X 8 X 4=224
# samples 27
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/224*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SP4 [Title/Abstract] AND GPNMB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSP4(21469210)-GPNMB(23313140), # samples:2
Anticipated loss of major functional domain due to fusion event.SP4-GPNMB seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSP4

GO:0006357

regulation of transcription by RNA polymerase II

12560508

TgeneGPNMB

GO:0001818

negative regulation of cytokine production

19350579

TgeneGPNMB

GO:0001934

positive regulation of protein phosphorylation

22891158

TgeneGPNMB

GO:0030335

positive regulation of cell migration

20711474

TgeneGPNMB

GO:0031954

positive regulation of protein autophosphorylation

19350579

TgeneGPNMB

GO:0034103

regulation of tissue remodeling

25010402

TgeneGPNMB

GO:0042130

negative regulation of T cell proliferation

19350579

TgeneGPNMB

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

19350579


check buttonFusion gene breakpoints across SP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPNMB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-1747-01CSP4chr7

21468410

-GPNMBchr7

23313140

+
ChimerDB4GBMTCGA-28-1747-01CSP4chr7

21469210

+GPNMBchr7

23313140

+


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Fusion Gene ORF analysis for SP4-GPNMB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000222584ENST00000478451SP4chr7

21468410

-GPNMBchr7

23313140

+
5CDS-3UTRENST00000222584ENST00000478451SP4chr7

21469210

+GPNMBchr7

23313140

+
5CDS-intronENST00000222584ENST00000409458SP4chr7

21468410

-GPNMBchr7

23313140

+
5CDS-intronENST00000222584ENST00000409458SP4chr7

21469210

+GPNMBchr7

23313140

+
5CDS-intronENST00000222584ENST00000453162SP4chr7

21468410

-GPNMBchr7

23313140

+
5CDS-intronENST00000222584ENST00000453162SP4chr7

21469210

+GPNMBchr7

23313140

+
5CDS-intronENST00000222584ENST00000539136SP4chr7

21468410

-GPNMBchr7

23313140

+
5CDS-intronENST00000222584ENST00000539136SP4chr7

21469210

+GPNMBchr7

23313140

+
Frame-shiftENST00000222584ENST00000258733SP4chr7

21468410

-GPNMBchr7

23313140

+
Frame-shiftENST00000222584ENST00000381990SP4chr7

21468410

-GPNMBchr7

23313140

+
In-frameENST00000222584ENST00000258733SP4chr7

21469210

+GPNMBchr7

23313140

+
In-frameENST00000222584ENST00000381990SP4chr7

21469210

+GPNMBchr7

23313140

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222584SP4chr721469210+ENST00000258733GPNMBchr723313140+273015924871845452
ENST00000222584SP4chr721469210+ENST00000381990GPNMBchr723313140+272915924871845452

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222584ENST00000258733SP4chr721469210+GPNMBchr723313140+0.0010728760.99892706
ENST00000222584ENST00000381990SP4chr721469210+GPNMBchr723313140+0.0010693850.99893063

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Fusion Genomic Features for SP4-GPNMB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SP4-GPNMB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:21469210/chr7:23313140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GPNMB

Q14956

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Could be a melanogenic enzyme. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPNMBchr7:21469210chr7:23313140ENST00000258733811520_572476561.0Topological domainCytoplasmic
TgeneGPNMBchr7:21469210chr7:23313140ENST00000381990811520_572488573.0Topological domainCytoplasmic
TgeneGPNMBchr7:21469210chr7:23313140ENST00000258733811499_519476561.0TransmembraneHelical
TgeneGPNMBchr7:21469210chr7:23313140ENST00000381990811499_519488573.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+16122_1300785.0Compositional biasNote=Poly-Ser
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+1612_190785.0Compositional biasNote=Poly-Ala
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+16185_1880785.0Compositional biasNote=Poly-Ser
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+167_110785.0Compositional biasNote=Poly-Glu
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+16467_4750785.0Motif9aaTAD%3B inactive
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+16647_6710785.0Zinc fingerC2H2-type 1
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+16677_7010785.0Zinc fingerC2H2-type 2
HgeneSP4chr7:21469210chr7:23313140ENST00000222584+16707_7290785.0Zinc fingerC2H2-type 3
TgeneGPNMBchr7:21469210chr7:23313140ENST00000258733811320_332476561.0Compositional biasNote=Poly-Pro
TgeneGPNMBchr7:21469210chr7:23313140ENST00000381990811320_332488573.0Compositional biasNote=Poly-Pro
TgeneGPNMBchr7:21469210chr7:23313140ENST00000258733811240_327476561.0DomainPKD
TgeneGPNMBchr7:21469210chr7:23313140ENST00000381990811240_327488573.0DomainPKD
TgeneGPNMBchr7:21469210chr7:23313140ENST0000025873381164_66476561.0MotifCell attachment site
TgeneGPNMBchr7:21469210chr7:23313140ENST0000038199081164_66488573.0MotifCell attachment site
TgeneGPNMBchr7:21469210chr7:23313140ENST0000025873381123_498476561.0Topological domainExtracellular
TgeneGPNMBchr7:21469210chr7:23313140ENST0000038199081123_498488573.0Topological domainExtracellular


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Fusion Gene Sequence for SP4-GPNMB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85407_85407_1_SP4-GPNMB_SP4_chr7_21469210_ENST00000222584_GPNMB_chr7_23313140_ENST00000258733_length(transcript)=2730nt_BP=1592nt
ATCAAGGGCGAGTCAGCCGGGCTCGGGCGGAGAGAGGAGCTGCTACGCCACAGCCCAGCGGCGGCCATTCGCGGAAAAAGAGGCAGAGCC
TGTGCCAGCTACAGCCTCCTCCGAGCCACCGCGGGCGGGCGGGACCGGCCTCTCCTCCCGCCTCGCCCCCACCCCCACCCACCTCTATCC
CAGTGTCTCCGTCTGAGGGTTTGTCCTGTTAATGCGGGATGAGCGATCAGAAGAAGGAGGAGGAGGAGGAGGCGGCAGCGGCAGCGGCGA
TGGCTACAGAAGGAGGGAAAACCTCTGAGCCAGAGAATAACAATAAAAAACCCAAAACCTCAGGCTCCCAGGTAATTCTTCCACCCCTGG
TCAATTTCAAGTCATACAAGTACAAAATCCAAGTGGTAGTGTACAGTACCAAGTAATTCCACAACTTCAGACAGTGGAAGGTCAACAAAT
TCAAATCAATCCAACTAGTAGTTCATCTCTACAGGATTTGCAGGGTCAAATTCAGCTCATTTCTGCAGGTAATAATCAAGCTATACTCAC
AGCTGCTAACAGGACAGCTTCTGGGAATATTCTTGCTCAAAACCTGGCAAATCAGACAGTTCCGGTCCAAATTAGACCTGGTGTTTCAAT
ACCACTGCAGTTACAGACTCTTCCTGGTACTCAGGCTCAAGTTGTAACAACCCTACCAATTAACATTGGAGGAGTGACTCTAGCTTTGCC
AGTGATAAACAACGTGGCTGCCGGAGGAGGGACTGGGCAGGTTGGCCAGCCTGCTGCTACTGCTGATAGTGGGACTTCCAATGGGAATCA
ATTAGTTTCCACACCCACCAACACCACTACTTCTGCCAGTACTATGCCAGAATCTCCCTCCTCCTCCACTACCTGCACAACCACTGCTTC
AACGTCTTTGACAAGCAGTGACACATTAGTGAGCTCAGCAGATACTGGCCAGTATGCAAGCACATCAGCCAGTAGTTCTGAACGCACCAT
TGAAGAATCTCAAACACCTGCTGCTACTGAGTCTGAAGCCCAGAGCTCCAGTCAGCTTCAGCCTAATGGAATGCAGAATGCACAGGATCA
ATCAAATTCTCTTCAGCAGGTGCAAATTGTAGGCCAACCTATCTTACAGCAGATCCAGATCCAACAGCCTCAGCAACAGATCATTCAGGC
TATTCCACCACAGTCGTTTCAACTCCAGTCAGGGCAGACGATTCAGACCATCCAGCAGCAGCCTTTACAGAATGTTCAACTTCAAGCAGT
AAATCCGACTCAGGTGCTTATCAGGGCTCCAACTTTAACACCTTCAGGGCAAATCAGTTGGCAAACTGTACAGGTTCAGAATATTCAGAG
TCTTTCAAATTTGCAAGTTCAGAATGCTGGGTTATCCCAACAATTAACCATCACCCCAGTGTCTTCAAGTGGTGGCACAACTCTTGCTCA
GATTGCTCCTGTGGCTGTTGCTGGTGCCCCAATAACTTTGAATACTGCCCAGCTTGCATCAGTGCCTAACCTTCAGACAGTGAGCGTTGC
CAACCTGGGTGCTGCAGGTGTTCAAGTGCAGGGAGTTCCCGTTACAATCACTAGTGTTGCAGACCCAGCCTCGCCTTTAAGGATGGCAAA
CAGTGCCCTGATCTCCGTTGGCTGCTTGGCCATATTTGTCACTGTGATCTCCCTCTTGGTGTACAAAAAACACAAGGAATACAACCCAAT
AGAAAATAGTCCTGGGAATGTGGTCAGAAGCAAAGGCCTGAGTGTCTTTCTCAACCGTGCAAAAGCCGTGTTCTTCCCGGGAAACCAGGA
AAAGGATCCGCTACTCAAAAACCAAGAATTTAAAGGAGTTTCTTAAATTTCGACCTTGTTTCTGAAGCTCACTTTTCAGTGCCATTGATG
TGAGATGTGCTGGAGTGGCTATTAACCTTTTTTTCCTAAAGATTATTGTTAAATAGATATTGTGGTTTGGGGAAGTTGAATTTTTTATAG
GTTAAATGTCATTTTAGAGATGGGGAGAGGGATTATACTGCAGGCAGCTTCAGCCATGTTGTGAAACTGATAAAAGCAACTTAGCAAGGC
TTCTTTTCATTATTTTTTATGTTTCACTTATAAAGTCTTAGGTAACTAGTAGGATAGAAACACTGTGTCCCGAGAGTAAGGAGAGAAGCT
ACTATTGATTAGAGCCTAACCCAGGTTAACTGCAAGAAGAGGCGGGATACTTTCAGCTTTCCATGTAACTGTATGCATAAAGCCAATGTA
GTCCAGTTTCTAAGATCATGTTCCAAGCTAACTGAATCCCACTTCAATACACACTCATGAACTCCTGATGGAACAATAACAGGCCCAAGC
CTGTGGTATGATGTGCACACTTGCTAGACTCAGAAAAAATACTACTCTCATAAATGGGTGGGAGTATTTTGGTGACAACCTACTTTGCTT
GGCTGAGTGAAGGAATGATATTCATATATTCATTTATTCCATGGACATTTAGTTAGTGCTTTTTATATACCAGGCATGATGCTGAGTGAC
ACTCTTGTGTATATTTCCAAATTTTTGTACAGTCGCTGCACATATTTGAAATCATATATTAAGACTTTCCAAAGATGAGGTCCCTGGTTT
TTCATGGCAACTTGATCAGTAAGGATTTCACCTCTGTTTGTAACTAAAACCATCTACTATATGTTAGACATGACATTCTTTTTCTCTCCT

>85407_85407_1_SP4-GPNMB_SP4_chr7_21469210_ENST00000222584_GPNMB_chr7_23313140_ENST00000258733_length(amino acids)=452AA_BP=368
MQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGTG
QVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESE
AQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTL
TPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGV
PVTITSVADPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKG

--------------------------------------------------------------
>85407_85407_2_SP4-GPNMB_SP4_chr7_21469210_ENST00000222584_GPNMB_chr7_23313140_ENST00000381990_length(transcript)=2729nt_BP=1592nt
ATCAAGGGCGAGTCAGCCGGGCTCGGGCGGAGAGAGGAGCTGCTACGCCACAGCCCAGCGGCGGCCATTCGCGGAAAAAGAGGCAGAGCC
TGTGCCAGCTACAGCCTCCTCCGAGCCACCGCGGGCGGGCGGGACCGGCCTCTCCTCCCGCCTCGCCCCCACCCCCACCCACCTCTATCC
CAGTGTCTCCGTCTGAGGGTTTGTCCTGTTAATGCGGGATGAGCGATCAGAAGAAGGAGGAGGAGGAGGAGGCGGCAGCGGCAGCGGCGA
TGGCTACAGAAGGAGGGAAAACCTCTGAGCCAGAGAATAACAATAAAAAACCCAAAACCTCAGGCTCCCAGGTAATTCTTCCACCCCTGG
TCAATTTCAAGTCATACAAGTACAAAATCCAAGTGGTAGTGTACAGTACCAAGTAATTCCACAACTTCAGACAGTGGAAGGTCAACAAAT
TCAAATCAATCCAACTAGTAGTTCATCTCTACAGGATTTGCAGGGTCAAATTCAGCTCATTTCTGCAGGTAATAATCAAGCTATACTCAC
AGCTGCTAACAGGACAGCTTCTGGGAATATTCTTGCTCAAAACCTGGCAAATCAGACAGTTCCGGTCCAAATTAGACCTGGTGTTTCAAT
ACCACTGCAGTTACAGACTCTTCCTGGTACTCAGGCTCAAGTTGTAACAACCCTACCAATTAACATTGGAGGAGTGACTCTAGCTTTGCC
AGTGATAAACAACGTGGCTGCCGGAGGAGGGACTGGGCAGGTTGGCCAGCCTGCTGCTACTGCTGATAGTGGGACTTCCAATGGGAATCA
ATTAGTTTCCACACCCACCAACACCACTACTTCTGCCAGTACTATGCCAGAATCTCCCTCCTCCTCCACTACCTGCACAACCACTGCTTC
AACGTCTTTGACAAGCAGTGACACATTAGTGAGCTCAGCAGATACTGGCCAGTATGCAAGCACATCAGCCAGTAGTTCTGAACGCACCAT
TGAAGAATCTCAAACACCTGCTGCTACTGAGTCTGAAGCCCAGAGCTCCAGTCAGCTTCAGCCTAATGGAATGCAGAATGCACAGGATCA
ATCAAATTCTCTTCAGCAGGTGCAAATTGTAGGCCAACCTATCTTACAGCAGATCCAGATCCAACAGCCTCAGCAACAGATCATTCAGGC
TATTCCACCACAGTCGTTTCAACTCCAGTCAGGGCAGACGATTCAGACCATCCAGCAGCAGCCTTTACAGAATGTTCAACTTCAAGCAGT
AAATCCGACTCAGGTGCTTATCAGGGCTCCAACTTTAACACCTTCAGGGCAAATCAGTTGGCAAACTGTACAGGTTCAGAATATTCAGAG
TCTTTCAAATTTGCAAGTTCAGAATGCTGGGTTATCCCAACAATTAACCATCACCCCAGTGTCTTCAAGTGGTGGCACAACTCTTGCTCA
GATTGCTCCTGTGGCTGTTGCTGGTGCCCCAATAACTTTGAATACTGCCCAGCTTGCATCAGTGCCTAACCTTCAGACAGTGAGCGTTGC
CAACCTGGGTGCTGCAGGTGTTCAAGTGCAGGGAGTTCCCGTTACAATCACTAGTGTTGCAGACCCAGCCTCGCCTTTAAGGATGGCAAA
CAGTGCCCTGATCTCCGTTGGCTGCTTGGCCATATTTGTCACTGTGATCTCCCTCTTGGTGTACAAAAAACACAAGGAATACAACCCAAT
AGAAAATAGTCCTGGGAATGTGGTCAGAAGCAAAGGCCTGAGTGTCTTTCTCAACCGTGCAAAAGCCGTGTTCTTCCCGGGAAACCAGGA
AAAGGATCCGCTACTCAAAAACCAAGAATTTAAAGGAGTTTCTTAAATTTCGACCTTGTTTCTGAAGCTCACTTTTCAGTGCCATTGATG
TGAGATGTGCTGGAGTGGCTATTAACCTTTTTTTCCTAAAGATTATTGTTAAATAGATATTGTGGTTTGGGGAAGTTGAATTTTTTATAG
GTTAAATGTCATTTTAGAGATGGGGAGAGGGATTATACTGCAGGCAGCTTCAGCCATGTTGTGAAACTGATAAAAGCAACTTAGCAAGGC
TTCTTTTCATTATTTTTTATGTTTCACTTATAAAGTCTTAGGTAACTAGTAGGATAGAAACACTGTGTCCCGAGAGTAAGGAGAGAAGCT
ACTATTGATTAGAGCCTAACCCAGGTTAACTGCAAGAAGAGGCGGGATACTTTCAGCTTTCCATGTAACTGTATGCATAAAGCCAATGTA
GTCCAGTTTCTAAGATCATGTTCCAAGCTAACTGAATCCCACTTCAATACACACTCATGAACTCCTGATGGAACAATAACAGGCCCAAGC
CTGTGGTATGATGTGCACACTTGCTAGACTCAGAAAAAATACTACTCTCATAAATGGGTGGGAGTATTTTGGTGACAACCTACTTTGCTT
GGCTGAGTGAAGGAATGATATTCATATATTCATTTATTCCATGGACATTTAGTTAGTGCTTTTTATATACCAGGCATGATGCTGAGTGAC
ACTCTTGTGTATATTTCCAAATTTTTGTACAGTCGCTGCACATATTTGAAATCATATATTAAGACTTTCCAAAGATGAGGTCCCTGGTTT
TTCATGGCAACTTGATCAGTAAGGATTTCACCTCTGTTTGTAACTAAAACCATCTACTATATGTTAGACATGACATTCTTTTTCTCTCCT

>85407_85407_2_SP4-GPNMB_SP4_chr7_21469210_ENST00000222584_GPNMB_chr7_23313140_ENST00000381990_length(amino acids)=452AA_BP=368
MQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGTG
QVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESE
AQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTL
TPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGV
PVTITSVADPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SP4-GPNMB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SP4-GPNMB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SP4-GPNMB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource