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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AVL9-MICU1 (FusionGDB2 ID:8544)

Fusion Gene Summary for AVL9-MICU1

check button Fusion gene summary
Fusion gene informationFusion gene name: AVL9-MICU1
Fusion gene ID: 8544
HgeneTgene
Gene symbol

AVL9

MICU1

Gene ID

23080

10367

Gene nameAVL9 cell migration associatedmitochondrial calcium uptake 1
SynonymsKIAA0241CALC|CBARA1|EFHA3|MPXPS|ara CALC
Cytomap

7p14.3

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionlate secretory pathway protein AVL9 homologAVL9 homolog (S. cerevisiase)calcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1
Modification date2020031320200313
UniProtAcc

Q8NBF6

Q9BPX6

Ensembl transtripts involved in fusion geneENST00000459629, ENST00000318709, 
ENST00000404479, ENST00000409301, 
ENST00000361114, ENST00000398761, 
ENST00000401998, ENST00000398763, 
ENST00000418483, ENST00000604025, 
Fusion gene scores* DoF score10 X 3 X 7=21022 X 15 X 11=3630
# samples 1230
** MAII scorelog2(12/210*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/3630*10)=-3.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AVL9 [Title/Abstract] AND MICU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAVL9(32535414)-MICU1(74268027), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAVL9

GO:0016477

cell migration

22595670

TgeneMICU1

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

TgeneMICU1

GO:0051260

protein homooligomerization

24514027

TgeneMICU1

GO:0051561

positive regulation of mitochondrial calcium ion concentration

24560927

TgeneMICU1

GO:0070509

calcium ion import

20693986


check buttonFusion gene breakpoints across AVL9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MICU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721AVL9chr7

32535414

+MICU1chr10

74268027

-


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Fusion Gene ORF analysis for AVL9-MICU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000459629ENST00000361114AVL9chr7

32535414

+MICU1chr10

74268027

-
3UTR-3CDSENST00000459629ENST00000398761AVL9chr7

32535414

+MICU1chr10

74268027

-
3UTR-3CDSENST00000459629ENST00000401998AVL9chr7

32535414

+MICU1chr10

74268027

-
3UTR-5UTRENST00000459629ENST00000398763AVL9chr7

32535414

+MICU1chr10

74268027

-
3UTR-intronENST00000459629ENST00000418483AVL9chr7

32535414

+MICU1chr10

74268027

-
3UTR-intronENST00000459629ENST00000604025AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-5UTRENST00000318709ENST00000398763AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-5UTRENST00000404479ENST00000398763AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-5UTRENST00000409301ENST00000398763AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-intronENST00000318709ENST00000418483AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-intronENST00000318709ENST00000604025AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-intronENST00000404479ENST00000418483AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-intronENST00000404479ENST00000604025AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-intronENST00000409301ENST00000418483AVL9chr7

32535414

+MICU1chr10

74268027

-
5CDS-intronENST00000409301ENST00000604025AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000318709ENST00000361114AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000318709ENST00000398761AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000318709ENST00000401998AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000404479ENST00000361114AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000404479ENST00000398761AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000404479ENST00000401998AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000409301ENST00000361114AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000409301ENST00000398761AVL9chr7

32535414

+MICU1chr10

74268027

-
In-frameENST00000409301ENST00000401998AVL9chr7

32535414

+MICU1chr10

74268027

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000404479AVL9chr732535414+ENST00000401998MICU1chr1074268027-1842930986328
ENST00000404479AVL9chr732535414+ENST00000361114MICU1chr1074268027-1842930986328
ENST00000404479AVL9chr732535414+ENST00000398761MICU1chr1074268027-1842930986328
ENST00000318709AVL9chr732535414+ENST00000401998MICU1chr1074268027-20633142211207328
ENST00000318709AVL9chr732535414+ENST00000361114MICU1chr1074268027-20633142211207328
ENST00000318709AVL9chr732535414+ENST00000398761MICU1chr1074268027-20633142211207328
ENST00000409301AVL9chr732535414+ENST00000401998MICU1chr1074268027-20262771841170328
ENST00000409301AVL9chr732535414+ENST00000361114MICU1chr1074268027-20262771841170328
ENST00000409301AVL9chr732535414+ENST00000398761MICU1chr1074268027-20262771841170328

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000404479ENST00000401998AVL9chr732535414+MICU1chr1074268027-0.0020247770.9979752
ENST00000404479ENST00000361114AVL9chr732535414+MICU1chr1074268027-0.001946410.99805355
ENST00000404479ENST00000398761AVL9chr732535414+MICU1chr1074268027-0.0020247770.9979752
ENST00000318709ENST00000401998AVL9chr732535414+MICU1chr1074268027-0.0021165880.9978834
ENST00000318709ENST00000361114AVL9chr732535414+MICU1chr1074268027-0.0020525750.9979474
ENST00000318709ENST00000398761AVL9chr732535414+MICU1chr1074268027-0.0021165880.9978834
ENST00000409301ENST00000401998AVL9chr732535414+MICU1chr1074268027-0.0020348990.9979651
ENST00000409301ENST00000361114AVL9chr732535414+MICU1chr1074268027-0.0019833540.9980166
ENST00000409301ENST00000398761AVL9chr732535414+MICU1chr1074268027-0.0020348990.9979651

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Fusion Genomic Features for AVL9-MICU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AVL9-MICU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:32535414/chr10:74268027)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AVL9

Q8NBF6

MICU1

Q9BPX6

FUNCTION: Functions in cell migration. {ECO:0000269|PubMed:22595670}.FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24313810, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26341627, ECO:0000269|PubMed:26903221, ECO:0000269|PubMed:27099988}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMICU1chr7:32535414chr10:74268027ENST00000361114412231_242179477.0Calcium binding1
TgeneMICU1chr7:32535414chr10:74268027ENST00000361114412421_432179477.0Calcium binding2
TgeneMICU1chr7:32535414chr10:74268027ENST0000039876309231_2420279.0Calcium binding1
TgeneMICU1chr7:32535414chr10:74268027ENST0000039876309421_4320279.0Calcium binding2
TgeneMICU1chr7:32535414chr10:74268027ENST0000041848307231_2420279.0Calcium binding1
TgeneMICU1chr7:32535414chr10:74268027ENST0000041848307421_4320279.0Calcium binding2
TgeneMICU1chr7:32535414chr10:74268027ENST00000361114412218_253179477.0DomainEF-hand 1
TgeneMICU1chr7:32535414chr10:74268027ENST00000361114412408_443179477.0DomainEF-hand 2
TgeneMICU1chr7:32535414chr10:74268027ENST0000039876309218_2530279.0DomainEF-hand 1
TgeneMICU1chr7:32535414chr10:74268027ENST0000039876309408_4430279.0DomainEF-hand 2
TgeneMICU1chr7:32535414chr10:74268027ENST0000041848307218_2530279.0DomainEF-hand 1
TgeneMICU1chr7:32535414chr10:74268027ENST0000041848307408_4430279.0DomainEF-hand 2
TgeneMICU1chr7:32535414chr10:74268027ENST00000361114412455_465179477.0RegionC-helix region
TgeneMICU1chr7:32535414chr10:74268027ENST0000039876309455_4650279.0RegionC-helix region
TgeneMICU1chr7:32535414chr10:74268027ENST000003987630999_1100279.0RegionPolybasic region
TgeneMICU1chr7:32535414chr10:74268027ENST0000041848307455_4650279.0RegionC-helix region
TgeneMICU1chr7:32535414chr10:74268027ENST000004184830799_1100279.0RegionPolybasic region
TgeneMICU1chr7:32535414chr10:74268027ENST000003987630953_4760279.0Topological domainMitochondrial intermembrane
TgeneMICU1chr7:32535414chr10:74268027ENST000004184830753_4760279.0Topological domainMitochondrial intermembrane
TgeneMICU1chr7:32535414chr10:74268027ENST000003987630934_520279.0TransmembraneHelical
TgeneMICU1chr7:32535414chr10:74268027ENST000004184830734_520279.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAVL9chr7:32535414chr10:74268027ENST00000318709+116173_34031649.0DomaincDENN
HgeneAVL9chr7:32535414chr10:74268027ENST00000318709+11617_16131649.0DomainuDENN
HgeneAVL9chr7:32535414chr10:74268027ENST00000318709+116342_59331649.0DomaindDENN
HgeneAVL9chr7:32535414chr10:74268027ENST00000318709+116214_23031649.0TransmembraneHelical
TgeneMICU1chr7:32535414chr10:74268027ENST0000036111441299_110179477.0RegionPolybasic region
TgeneMICU1chr7:32535414chr10:74268027ENST0000036111441253_476179477.0Topological domainMitochondrial intermembrane
TgeneMICU1chr7:32535414chr10:74268027ENST0000036111441234_52179477.0TransmembraneHelical


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Fusion Gene Sequence for AVL9-MICU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8544_8544_1_AVL9-MICU1_AVL9_chr7_32535414_ENST00000318709_MICU1_chr10_74268027_ENST00000361114_length(transcript)=2063nt_BP=314nt
GTGTCAGGTGACAGCCCGGAAGCTGCGGAAGCGGATGAGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCG
ATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGACACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCC
TTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCCGCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTAC
TGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGCCAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATAT
TTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAA
TTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCGCTCCCAAACCA
GTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAG
CTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCC
ATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCA
TGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTA
ATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTA
AAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTT
CCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCAC
AGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCC
GCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCC
TCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTG
TAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCA
ACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTA
AAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTG
TGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACA
CAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGA
CCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGG

>8544_8544_1_AVL9-MICU1_AVL9_chr7_32535414_ENST00000318709_MICU1_chr10_74268027_ENST00000361114_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_2_AVL9-MICU1_AVL9_chr7_32535414_ENST00000318709_MICU1_chr10_74268027_ENST00000398761_length(transcript)=2063nt_BP=314nt
GTGTCAGGTGACAGCCCGGAAGCTGCGGAAGCGGATGAGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCG
ATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGACACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCC
TTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCCGCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTAC
TGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGCCAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATAT
TTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAA
TTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCAAACCA
GTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAG
CTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCC
ATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCA
TGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTA
ATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTA
AAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTT
CCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCAC
AGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCC
GCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCC
TCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTG
TAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCA
ACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTA
AAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTG
TGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACA
CAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGA
CCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGG

>8544_8544_2_AVL9-MICU1_AVL9_chr7_32535414_ENST00000318709_MICU1_chr10_74268027_ENST00000398761_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_3_AVL9-MICU1_AVL9_chr7_32535414_ENST00000318709_MICU1_chr10_74268027_ENST00000401998_length(transcript)=2063nt_BP=314nt
GTGTCAGGTGACAGCCCGGAAGCTGCGGAAGCGGATGAGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCG
ATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGACACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCC
TTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCCGCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTAC
TGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGCCAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATAT
TTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAA
TTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCAAACCA
GTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAG
CTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCC
ATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCA
TGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTA
ATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTA
AAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTT
CCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCAC
AGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCC
GCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCC
TCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTG
TAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCA
ACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTA
AAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTG
TGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACA
CAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGA
CCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGG

>8544_8544_3_AVL9-MICU1_AVL9_chr7_32535414_ENST00000318709_MICU1_chr10_74268027_ENST00000401998_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_4_AVL9-MICU1_AVL9_chr7_32535414_ENST00000404479_MICU1_chr10_74268027_ENST00000361114_length(transcript)=1842nt_BP=93nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC
CAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGAC
TACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTA
GATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAAC
ACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAA
TTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGT
GGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGT
CTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGA
GCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCA
CTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCC
AAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCC
CACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAA
GTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGAT
TCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATT
CAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGG
ATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGT
CTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTG
GGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTG
TGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCC
TGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATA

>8544_8544_4_AVL9-MICU1_AVL9_chr7_32535414_ENST00000404479_MICU1_chr10_74268027_ENST00000361114_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_5_AVL9-MICU1_AVL9_chr7_32535414_ENST00000404479_MICU1_chr10_74268027_ENST00000398761_length(transcript)=1842nt_BP=93nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC
CAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGAC
TACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTA
GATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAAC
ACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAA
TTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGT
GGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGT
CTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGA
GCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCA
CTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCC
AAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCC
CACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAA
GTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGAT
TCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATT
CAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGG
ATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGT
CTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTG
GGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTG
TGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCC
TGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATA

>8544_8544_5_AVL9-MICU1_AVL9_chr7_32535414_ENST00000404479_MICU1_chr10_74268027_ENST00000398761_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_6_AVL9-MICU1_AVL9_chr7_32535414_ENST00000404479_MICU1_chr10_74268027_ENST00000401998_length(transcript)=1842nt_BP=93nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC
CAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGAC
TACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTA
GATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAAC
ACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAA
TTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGT
GGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGT
CTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGA
GCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCA
CTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCC
AAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCC
CACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAA
GTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGAT
TCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATT
CAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGG
ATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGT
CTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTG
GGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTG
TGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCC
TGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATA

>8544_8544_6_AVL9-MICU1_AVL9_chr7_32535414_ENST00000404479_MICU1_chr10_74268027_ENST00000401998_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_7_AVL9-MICU1_AVL9_chr7_32535414_ENST00000409301_MICU1_chr10_74268027_ENST00000361114_length(transcript)=2026nt_BP=277nt
AGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCGATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGA
CACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCCTTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCC
GCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGG
CTGCCAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTC
AGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGA
AGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGG
CAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCT
CGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTT
TGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAA
GGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGC
TGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTT
TGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAA
GCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTA
ACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCT
GGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTC
TGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACC
CATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCT
ATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAG
AAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTC
CCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGC
TCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGT
TCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTA

>8544_8544_7_AVL9-MICU1_AVL9_chr7_32535414_ENST00000409301_MICU1_chr10_74268027_ENST00000361114_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_8_AVL9-MICU1_AVL9_chr7_32535414_ENST00000409301_MICU1_chr10_74268027_ENST00000398761_length(transcript)=2026nt_BP=277nt
AGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCGATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGA
CACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCCTTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCC
GCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGG
CTGCCAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTC
AGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGA
AGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGG
CAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCT
CGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTT
TGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAA
GGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGC
TGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTT
TGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAA
GCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTA
ACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCT
GGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTC
TGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACC
CATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCT
ATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAG
AAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTC
CCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGC
TCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGT
TCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTA

>8544_8544_8_AVL9-MICU1_AVL9_chr7_32535414_ENST00000409301_MICU1_chr10_74268027_ENST00000398761_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

--------------------------------------------------------------
>8544_8544_9_AVL9-MICU1_AVL9_chr7_32535414_ENST00000409301_MICU1_chr10_74268027_ENST00000401998_length(transcript)=2026nt_BP=277nt
AGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCGATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGA
CACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCCTTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCC
GCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGG
CTGCCAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTC
AGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGA
AGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGG
CAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCT
CGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTT
TGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAA
GGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGC
TGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTT
TGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAA
GCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTA
ACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCT
GGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTC
TGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACC
CATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCT
ATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAG
AAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTC
CCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGC
TCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGT
TCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTA

>8544_8544_9_AVL9-MICU1_AVL9_chr7_32535414_ENST00000409301_MICU1_chr10_74268027_ENST00000401998_length(amino acids)=328AA_BP=31
MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEV
DMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFG
GMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFA

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Fusion Gene PPI Analysis for AVL9-MICU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AVL9-MICU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AVL9-MICU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource