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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPAG6-PLXDC2 (FusionGDB2 ID:85445)

Fusion Gene Summary for SPAG6-PLXDC2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPAG6-PLXDC2
Fusion gene ID: 85445
HgeneTgene
Gene symbol

SPAG6

PLXDC2

Gene ID

9576

84898

Gene namesperm associated antigen 6plexin domain containing 2
SynonymsCFAP194|CT141|FAP194|Repro-SA-1|pf16TEM7R
Cytomap

10p12.2

10p12.31

Type of geneprotein-codingprotein-coding
Descriptionsperm-associated antigen 6axoneme central apparatus proteinprotein PF16 homologsperm flagellar proteintesticular tissue protein Li 176plexin domain-containing protein 21200007L24Riktumor endothelial marker 7-related protein
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313311, ENST00000376603, 
ENST00000376624, ENST00000538630, 
ENST00000376601, ENST00000490361, 
ENST00000377238, ENST00000377242, 
ENST00000377252, 
Fusion gene scores* DoF score2 X 2 X 2=811 X 10 X 5=550
# samples 211
** MAII scorelog2(2/8*10)=1.32192809488736log2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPAG6 [Title/Abstract] AND PLXDC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPAG6(22657607)-PLXDC2(20568632), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SPAG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLXDC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A2I1-01ASPAG6chr10

22657607

-PLXDC2chr10

20568632

+
ChimerDB4BLCATCGA-DK-A2I1-01ASPAG6chr10

22657607

+PLXDC2chr10

20568632

+


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Fusion Gene ORF analysis for SPAG6-PLXDC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000313311ENST00000377238SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
5CDS-3UTRENST00000376603ENST00000377238SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
5CDS-3UTRENST00000376624ENST00000377238SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
5CDS-3UTRENST00000538630ENST00000377238SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
Frame-shiftENST00000313311ENST00000377242SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
Frame-shiftENST00000376603ENST00000377242SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
Frame-shiftENST00000376624ENST00000377242SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
Frame-shiftENST00000538630ENST00000377242SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
In-frameENST00000313311ENST00000377252SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
In-frameENST00000376603ENST00000377252SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
In-frameENST00000376624ENST00000377252SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
In-frameENST00000538630ENST00000377252SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
intron-3CDSENST00000376601ENST00000377242SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
intron-3CDSENST00000376601ENST00000377252SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
intron-3CDSENST00000490361ENST00000377242SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
intron-3CDSENST00000490361ENST00000377252SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
intron-3UTRENST00000376601ENST00000377238SPAG6chr10

22657607

+PLXDC2chr10

20568632

+
intron-3UTRENST00000490361ENST00000377238SPAG6chr10

22657607

+PLXDC2chr10

20568632

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538630SPAG6chr1022657607+ENST00000377252PLXDC2chr1020568632+111239695721003143
ENST00000376603SPAG6chr1022657607+ENST00000377252PLXDC2chr1020568632+10996842142876244
ENST00000376624SPAG6chr1022657607+ENST00000377252PLXDC2chr1020568632+10768614142648168
ENST00000313311SPAG6chr1022657607+ENST00000377252PLXDC2chr1020568632+10741587115621168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538630ENST00000377252SPAG6chr1022657607+PLXDC2chr1020568632+0.0039220.99607795
ENST00000376603ENST00000377252SPAG6chr1022657607+PLXDC2chr1020568632+0.0009670720.999033
ENST00000376624ENST00000377252SPAG6chr1022657607+PLXDC2chr1020568632+0.0014894010.99851054
ENST00000313311ENST00000377252SPAG6chr1022657607+PLXDC2chr1020568632+0.0014888050.99851114

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Fusion Genomic Features for SPAG6-PLXDC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPAG6chr1022657607+PLXDC2chr1020568631+5.30E-050.99994695
SPAG6chr1022657607+PLXDC2chr1020568631+5.30E-050.99994695

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPAG6-PLXDC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:22657607/chr10:20568632)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+410115_154157459.0RepeatNote=ARM 3
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+41031_70157459.0RepeatNote=ARM 1
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+41073_112157459.0RepeatNote=ARM 2
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+411115_154233586.0RepeatNote=ARM 3
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+411157_196233586.0RepeatNote=ARM 4
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+41131_70233586.0RepeatNote=ARM 1
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+41173_112233586.0RepeatNote=ARM 2
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+411115_154157510.0RepeatNote=ARM 3
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+41131_70157510.0RepeatNote=ARM 1
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+41173_112157510.0RepeatNote=ARM 2
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+71431_70132485.0RepeatNote=ARM 1
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+71473_112132485.0RepeatNote=ARM 2
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772421113476_529442481.0Topological domainCytoplasmic
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772421113455_475442481.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+410157_196157459.0RepeatNote=ARM 4
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+410199_238157459.0RepeatNote=ARM 5
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+410241_280157459.0RepeatNote=ARM 6
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+410325_365157459.0RepeatNote=ARM 7
HgeneSPAG6chr10:22657607chr10:20568632ENST00000313311+410368_409157459.0RepeatNote=ARM 8
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+17115_1540271.0RepeatNote=ARM 3
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+17157_1960271.0RepeatNote=ARM 4
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+17199_2380271.0RepeatNote=ARM 5
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+17241_2800271.0RepeatNote=ARM 6
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+1731_700271.0RepeatNote=ARM 1
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+17325_3650271.0RepeatNote=ARM 7
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+17368_4090271.0RepeatNote=ARM 8
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376601+1773_1120271.0RepeatNote=ARM 2
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+411199_238233586.0RepeatNote=ARM 5
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+411241_280233586.0RepeatNote=ARM 6
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+411325_365233586.0RepeatNote=ARM 7
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376603+411368_409233586.0RepeatNote=ARM 8
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+411157_196157510.0RepeatNote=ARM 4
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+411199_238157510.0RepeatNote=ARM 5
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+411241_280157510.0RepeatNote=ARM 6
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+411325_365157510.0RepeatNote=ARM 7
HgeneSPAG6chr10:22657607chr10:20568632ENST00000376624+411368_409157510.0RepeatNote=ARM 8
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+714115_154132485.0RepeatNote=ARM 3
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+714157_196132485.0RepeatNote=ARM 4
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+714199_238132485.0RepeatNote=ARM 5
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+714241_280132485.0RepeatNote=ARM 6
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+714325_365132485.0RepeatNote=ARM 7
HgeneSPAG6chr10:22657607chr10:20568632ENST00000538630+714368_409132485.0RepeatNote=ARM 8
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772421113383_427442481.0Compositional biasNote=Thr-rich
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772521214383_427491530.0Compositional biasNote=Thr-rich
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772421113327_372442481.0DomainNote=PSI
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772521214327_372491530.0DomainNote=PSI
TgenePLXDC2chr10:22657607chr10:20568632ENST00000377242111331_454442481.0Topological domainExtracellular
TgenePLXDC2chr10:22657607chr10:20568632ENST00000377252121431_454491530.0Topological domainExtracellular
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772521214476_529491530.0Topological domainCytoplasmic
TgenePLXDC2chr10:22657607chr10:20568632ENST000003772521214455_475491530.0TransmembraneHelical


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Fusion Gene Sequence for SPAG6-PLXDC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85445_85445_1_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000313311_PLXDC2_chr10_20568632_ENST00000377252_length(transcript)=10741nt_BP=587nt
GAGAAGCGGCTCCCGTCGGAGGCCGAGTCGTCGCCACGATCGCCCCCTTGGTGGACTCGCAGGCCGAGCGGCTTCCCCGCAGAGCTCGAG
GAGGGCAGACGGCGGCGGGGGCGCCATGAGTCAGAGGCAGGTGCTGCAAGTGTTCGAGCAATACCAGAAGGCCAGGACCCAGTTCGTGCA
GATGGTGGCGGAGCTGGCGACTAGACCCCAAAACATCGAGACGCTGCAGAACGCGGGTGTAATGTCTTTGCTGAGAACTCTTCTTCTGGA
CGTGGTCCCAACAATTCAACAGACTGCTGCTTTGGCTCTTGGGAGACTGGCCAATTATAATGATGACCTAGCAGAAGCTGTTGTGAAGTG
CGACATTCTTCCACAGCTTGTTTATTCATTGGCAGAACAGAATCGCTTCTACAAGAAAGCAGCTGCCTTTGTGTTACGAGCAGTTGGTAA
ACATTCTCCCCAGCTAGCTCAGGCAATAGTCGATTGTGGAGCACTGGATACGCTGGTCATATGCTTGGAAGATTTTGACCCTGGAGTCAA
GGAGGCTGCAGCCTGGGCACTTAGATATATTGCAAGACATAATGCAGAGACGCCCAAGCAGATGGCCTGCGATGAAGTTTAGAAGAGGCT
CTGGACATCCTGCCTATGCTGAAGTTGAACCAGTTGGAGAGAAAGAAGGCTTTATTGTATCAGAGCAGTGCTAAAATTTCTAGGACAGAA
CAACACCAGTACTGGTTTACAGGTGTTAAGACTAAAATTTTGCCTATACCTTTAAGACAAACAAACAAACACACACACAAACAAGCTCTA
AGCTGCTGTAGCCTGAAGAAGACAAGATTTCTGGACAAGCTCAGCCCAGGAAACAAAGGGTAAACAAAAAACTAAAACTTATACAAGATA
CCATTTACACTGAACATAGAATTCCCTAGTGGAATGTCATCTATAGTTCACTCGGAACATCTCCCGTGGACTTATCTGAAGTATGACAAG
ATTATAATGCTTTTGGCTTAGGTGCAGGGTTGCAAAGGGATCAGAAAAAAAAAATCATAATAAAGCTTTAGTTCATGAGGGATCGACACC
TTTGGTTCAAATGTTCTCTGATGTCTCAAAGATAACTGTTTTCCAAAGCCTGAACCCTTTCACTCAAAAGAGCAATGATGAATGTCTCAA
GATTGCTAAGAAAAACAGCCCATGCAAGAGTGAGAACAAACACAAAATAAGAGATTTTCTACATTTTCAAAACAGATGTGTGGCAAAAGG
ATGTTGTTTTTCTGGTCTAGATCCATCTGTACCAACAAGTTCATCACTTTACAGAACGAATCTTTTTATCCGTACAGGAGGTTCAAACCA
TGTCTGCCTCTTCCTTTGTAATGAATGACCTTTCTATGAGCTGTGACAAAATTTCCGAACAATTAACTAAGGATTTGGGAAGAGGGGGTG
GCAAACGGGGCTTTCTGTTTTCCTGCCTCAGCATGAAAACATCTGATTTATGCTTTATGGAAGCCTTACCTCCAATCCCCAACTGTTAAG
TCCCATGAAACCACAGTTGCTCTGGGCTGATGGAAACAAAAGGAAACAGTATGAAGAGTTCCTTAATCATTTTTGAAACAAAAATGTTAA
GGGATTTTAAACATATGATTATTTTTAATTTTATGCCTTTTCAGTACTAAACACCCATTTCATTGCTGATTCCTGTCTAAGAAGCCATTC
ACGTCAGCATGGCGATAGAAAGAATGAAAAAACCCTGCTGAATCATACAGTAATTTTCTTTAAAGCACATAGTAGTTACATAAATATATA
TATATAAATATATTTTTGTTTATAACTAACACAAGGCAGGATCTTGTGACTCTAAGAGTGCGTTTTGTCATCAAGGCAAAACAGATGCAA
GATGCATCACTGCATTACTTCCATAGAGTTGTAAAATAATCCTTAATATTAGAATATTTTTCTGTCACTTAGCAAAAGTGGTTCAGTTCA
TTGCCGCGCCCATCATGTTCTTGACTATTTGATCCACTTTTTCGTTTATGTCAACCCCTTCCCTCTCTGGCTAAATAAAGTGGATGCAGA
AAGCTCCTTAAATGGAGATATCGATTGCCTTGGAATCACAATCCTGATTTTGAAAATTCCTCATGAATGAAGAAAGGAATGGCATCCCTT
GAGAAGGAAAGTGGTTAATATACATACTGAGCTCCTAAAGTTTAAATTCAGGTACTGAGTGTACAATTTCACCAACATTCTAACCCATGA
AACTTTTACACTCTGTGCCAAGAAACTGTTGGCTTTTGTAAGGTACAGTGCTCAACATTTGCAGATTCAGGTCTCAAGAAGCAGAGATGT
CTCATAAGCAGCATTTTCCCAACAGTTTAGCATCTGTACACATCTGCCTTGGTCATCAGTCCACTCACAGAGTACCATACTTTATCATCA
CAAGTGTCTGACGTGAACGAATGCCATTTTCTATTCCATATATTTTGCTTTACAATTTTAAGTATTTGATGAAGATGGTAACTTTTTCCT
AACTTAGTTAACTATTAAAAAAAATTTTGAAAAGCAAGGTGATTGAAGGATTGTGATGACAATCTCTTTGCAGCAGCTATGTATGGTTTA
TGTGAAGTATCCCCACTTATTCTTGTGGAGCAGGTTTGGTGAGACAGCAATAACCAAATGACATGCCAATATTACTGGTGCAACTGGTAT
TCTACAAATGCATAAGGAACACATAGACGACTTCCTTTTAGGATAAAATGATGCTTCTTTCACTACCTTTTGTGGTAGCTGTGGCTTCCA
ATAGCAACTGTTTGACAGTTATATAAATCTTGCATGTGTATTCTTAGTTTGTGTCCCTTAAGTACTACTTAATTCTCAAGTAGTAATGTT
ATTCTTATACCCTTCAGCGTTCTATTTTGATTCAAAACAATTGATTCAAAACAATTTTGAATCAATTTTCTATTTTGATTCAAAACAATT
GATAATTCTGTAAAAAAACATAAACACTGAATTCTTCAGTGAACCAAAGCAACAAATAATAGAGAAAACTTCTTGAAACTGGAGTGTGGG
AAAACTTCTTAACAGAACTAAGAGTTAAAGGTAGTGAGAAGTGTGTGGTGTGTGAATTCTTTAGTGGTAAGGGGAAATGTGGGCTAAATC
CTTTTCTTTCATGAAACTCTCATTCTATTTTATATTTCTGGTTTGTTCTTGTTCCCATGTGAGAAAACATACAGTTTCTGAAAATTCAAA
ATGGTCATCAATGCTTTGGACTTTACATAATTATGTATTAGAGAAGGTGCAACTGTACATTACTTAATATACTATGAACATAATAGAATA
ACAAAAAAAGATAACAAAGAGATGCAAACTTCTGGATAAATCAGATAAATGGTGCTACAGAGGAATTTAGTTATTTCAGCTTAATTATTT
GTAAAAATAATAATCAGTGACTAGGTAAAGATACTGAAACTCAAGAAAAATATCTTGACCCATTTATGTCTAGTGTTCCATTATTGGAAC
GCTAAGCTTATGGGAGTTATTTAGAGCCTACTGCTCAAGGTCATCACCAAGGTCTGGTTGCAAAAATTCAAAAAATTGCAACCTCAGGCA
TAAATGGCTTAAGCCCAAGAGATGGCACTGACCATAAATGGTGGCTTGTGTGTGAAGGGTTTGGACTTCAAGATATACTAACACCTAGAA
AACTAAAAGTGCAATTGACCCCCAATTACTATTTTAGTTTGAGGTATCAAGGGCATTTGCCAATCTCTTATATGTAGCTTCTAGAGTTGT
GCTGTCCAATATTATATCCACTAGCCAACGTGGCTTTTGAAATTAAAATTAATTAAAATTAAATTAAAAATGTAATTCTTCAGTCACACC
AGCCACATTTCAAAGGCTCAATAGCCACGCCTGGCTTGTGGCTACCATATTGGATAACAAGAAACACTTCCGTGGTTGAAGAAAATTTTA
ATGGACAATGCTGTGTTTCATTTGAATTCGTTGTCCTTGAAGAAAAGGGAAGAAGAGGAAAGAAACAAGATTTGGTAGCTCTTGGGCATA
TCCAAGCATTTTTGATTTTAGAGAGGCCCTATGGAGTAATGAAAAAAATACAAGCTGACACAGCTTTAAATCCCCACTGTGTTATCTTGG
GAAAATCACTTCAACCTCCTTGAGTCTCAATTTGCAATTTTGGAAAAGAAAAACAATTTTTGTCCTGTCTTTCTTGCAAGATTATTATGC
AACCTGATTAAATGTACAGATGTGCAGACTCTTAAAAACCTTATGTTAATGTAACCCATATAAAGTACGACTTTTGGTCGAGTACCAGCA
CAAATTTGCATTCAAAGGAAGAATAGTTCATCAGTGCAAAAAGCGTTCAAAGGTAATCAGTTCATCACGTATCTTGAGAAAAAGAGAATG
CATTCAAAACACAAAGCAAAATTGCTTCAGTTTCTTTTCTGCCCATCTGAATATTTCCTTTAGTATTTGTCCCACATGACATCCATCCCA
TGTATTTATCCACTCTTTCACAACATTGCCTATGAACATCCTTCAACTGGCTCAGTTCTTTATTGCATAGAGCCACTTAGCTTCTCTAGT
TTCTTATGATTTCCTATTTTACACTTAACAGCAAAAGGAGGCTTCCATTTAGAAGGCACTATCTCAAACATAAATAATTTCATATTTATT
TTATCACTGTAACACTAAGGAGCTATGGCATTAAAATATAAAACTATTTGGAACTTAATGTAAACCTTTGCACATGCAGACTATATAAAG
GGAATAAAATTATTTTAAATTATGCTAATATCCAGATACATATTCTAAGGTTAGTATCATTTATCAGTTTTTCGCAACAGATTCTTATGT
TACATCTTCATGAGGGAGTATAAATTTGATCACGTCCCTAGTGTCTATTGCCCACTTGAGAAAGGTTTTGCCAGGATCCACAGATCGCTT
CAAGATGCTTTCGTTTATGATAGGAAATTAATATTTAAATAAGACTAATTGAAAACTAGATTATCTGGTTCTAATTTCTTCCTCCTGTGA
AATGTTCTTTTGGTTTGTATTTCTTTAGGTATTTTCCAAGTTACTGCTGCTTTTACTTCACGACCTCCAACCCCACTTTTGTTATCAGCG
TCATATGCCAGAGTCATGGCAGATCCAGCCTGGACAACATAGTGAGACCCATCTCTATCAAATATACATATATATATATATATATACACA
CACACACACACACACACAAATATACATATATATCAAATATATATGTATATTTGATAGAGATGATAGCAATTATGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTTAGCCAAGTGTGGTTTCTCATGCCTGTAGTCCCAGCTACTTTGGAGGCTGAAGTGTAAGAGTTGCTTGAGCCCAT
GAGTTAGAGGCTGCTGTGAGCTATGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAAACCCCATCTCTAAATAAAAAAAAAGAA
TCGTGAGACATCATGTAATCCAACCTCTTAATGTTACAGATAAGTAAACTGAGGCCCAAAGAGATATAGTAATAGTCCCAGTGTCAGTAA
ACTGGGTCTTGAACTTAAATGTTTGTTTCAGTTCTCATTGCCTTCATCTCTTAATTGTCGGCACTTAAGGCCAACCAAGCAGCTTAGACA
GCGCAGTCCACTCAACGGTAACTTTATTTGCTATATTGACAATCTGCTCTGTTCTGTAATATAGAACATTGGATCAATCTTTATCTTTTT
GCTGACTTAAGGAGGCTGCTATTGTTGCAATATCCAGAGATTTCAAGTTCTAGCCATTGCGGGGTCTTTGTGGTGTTTTCAATTTCTCCT
CTCTCCACCCCTGCCCCCATCTGTGGCCATCTAAGTTAGCAATACAATTTATTTTGGCCATTTAAAATTTTTCTGCCTTTGTTTTATTTC
TTCCCAAATATATTTGAAAATGAATGATCTATATAGCTGATTTTCTGACCACATATATAATTGCAATTTTTATTTGCTCTTCAAACTATT
ACAACATTTTTGTCCTTATAAGGTTTTTTGGGCAGATAATGCGAGGTCTGTGGTGTTACCTTTTATATACTCCTATTACCTTATGTTTGT
GAAGCATTTTACATTTTACAGAGCACTTTGATTCATCTCCCTATTTGTTCATTTATTTAACTGTTCAGTTCACTGAAATATTTATTGAAC
ACCTACTGGAACCAAGTGACTGTGCTAGTAACTTGTGATATACAGTAGTGAGAGTCCAGGCATGTAACCGATCATTATAATACAATAACA
TCCCTAAACCAGACTTTACAAGTAGATAGGATCAACAATACTCTATCAATTTTCAACTCCAATTTTCTATTCTACTTAAAATGGGAACTA
GAAACTGTTTGCCTGAAGAATGTGTCTGAAACATAATATATCACTGCATGTCTGTGCTGTAGACCTGTTAATTTTATCTGTGAGAAAAAA
AGTTACTCAAAATTCTCCCTGACCTAAGAATACTTTCTAGTTCACTGCAGTCTTACTGACCAGATGCAACAGTTGAAGTTTGATTTCTCG
ACCCAATATTTCTATTGGGTTTTGAATTATTAATATCACTGTTTTGAGGTATTCAGAAACACCAGTGTATCAAAAAAGCATTTGCACTTT
AGGTGTGTGTGGTGGTTATGTCATTTATTAGACCATCCCAGACATAAGACAATCAGGGAAATCAGAAAACTCCAGCCTCAAATGTGTCTA
TAATTTCCTGTTCTACCATTGTCATATCATAACATGGTATTACTTCTTAAGGTTTTGATTAAGTTGATCTAGCCTCAACTTAAATTGTAA
TACATCTGCCTAATTATTGTCTGGAATAACTTTTCAACCATCCAATGCCCACTGCTCTCACAATGATTATTGTAGAGAAGTAAAATGGTA
ATTATTCAAGTAAAGTCACATAATTTCTGGAGTCAGTTTTTCATAACAAGTTTATGGAATACATCATCATTGGCTTCTTCATAATATATT
TATTATGAGTGACCAAATTTTGCCTGGAGGAGCAAAATGCTCAAAACTTGTTATTATAGGTTAATTTCCAGCTCACTGTTGACACTGAAA
GATTCTGTGTTACTTTAAACCCAGGATAAAAGGCTGGAAAAAAAATTAAATGTAAGTCATAAACTAGTACTCAGCTTTTCCTAGTTTCTA
AGGCTTATTAACATTTGCAAATTACTCAATAAATGTCTTTCATAATGGAATAACATAAAAGCTTTTGATTTGGCAGATAGTGATATTTTA
TTTATTTTCATTCTGGTTGAAAAAAATCTCAGTGGCTTCTCTTCATTCCACGAGAATTTTGATTTTTAACAGCAGTCTCTCTTTTTCTCA
GCATTGCAAATATATATGTATATATACATTCATGACCAAAGTATCGCTTACTGACCATGCAGCTGTAAACCTTCTGTGCCTATCAAACAA
ATACATAGCATGAAACTAATTTTAGAAGTTTCATGGGGGAATTTTAGGGGAAAGTATAAACCTAAGAGTGAGTGAATGGAGATGATTCAT
GGAAAAAAAAATAAAAATCTAAATGTGCTATTAGGCAGAGTTATTAACTTCTTTTAGTTGTTGTTTGAGATGGGGTTTTGCTCTTGTTAC
CCAGGCTGGAGTGCAATGGCGTGATCTCGTCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCGCCCAAGTAG
CTGGGATTACAGGCATATGCCACTACAGCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGCTGGTCAGGCTGGTCCCCA
GCTCCCGACCTCAGGTGATCCGCCCACCTCCGCCTCCCAAAGTGCTGGAATTACAGGCCTGAGCCACCGTGCCTGGCCGAGTTATTAACT
TCTTAAGAGCAATGTGCTAATAAATACTCATTGATGACCAGCTCAAATTTAGGTCATTCAGACATCCAGACACTGGGGCACATATTCTGC
AAGCAATGCTGAGACCCCTGACATAGAGAAAGCAAAGGATATGCCTATGATTAGTCTAAAATGCAGCCATCACCCCCCATACCTCTTCTA
TGGCATTCATCCTAACATCATGGAGGCCTTTGTCCTAGAGAATTATGTGACTTGCCCTAGAGAATTAGTGAATGACCAAAAAGAGACTTT
CCATTTATCTTCCTTTGACTTAAAAGGCATGAAAATAAGGCAAAAAAATCAATAAAATAATTTTCCTGAGGAAAGGTTAAGAGATGGCAC
TTTCCTTTCCGGGCCCAGAGCTGGATTTCTCTGAGATTTGACCATCTCAGGACTCAGACAGACTCCAGTGCTATTTTCTGGACATTTGTG
GTGAAGCCTCAGCCACCATGTTCAAGGTGGTTTGAATGAAAACATACTCAGATTGTCACATTTATAGCAGGGAAATAAAAACTCAAATTA
GGCATCCTGCAGCAGGCTACTCTGAAAATAACATTAGGCAACATCAGAGCTTCACTTGCAAAGAAATGTTAAAATCATTTTAGGGAAATC
AGTGAAGTCTCTTTAGAAACAGACATCTTGTGTATGGCGTAACCCAGTCTTGGGGCCCTCACGGAGAAGAGGGGGAAGTCTTTTCATTGA
TTGGTCAAAACAAATCTCTCATTTGCCTGATTTGAAGCATTTCAACAGTGCCTGGAGAGTACATTATTTTCAGGGGAAAAAAAGGAGAGA
GTCTTTTTTATATGCCAGCTGGGATCATGGGAACTTCGAATGCCAGGAATTTACTACTGTTTCTGGTAATTCTGTGTGTAGTCATTTGAA
ATGTTGAAGTGTGAAAAGAGAAGAAATTGGGCACTTCTTGCGGCGGGGGAGGGGGGGGGGGCGGTGGCTTTCCAGATTTTATGCCAGTTG
CACCAGCATGCAGAATATTTGTAATGCATTTCAAAGTGGATATAATGGCACCCTTTGTCAGAATCACAAAGCTCACTGCGGCACTGCTAC
AAGAGGACACTGAGGAAAATCTGGCCCTATGAACCTAGTCAACCCCAAGCAAAAAGAATGACTATGTGTGTGAGTGCAGCACATGGCCAG
TTCGTTTCTCACTGTTTTGGAAAGCCCTGTGTGCCAAACCAAGGACGTGTCTTTCAGGGAAAGGTTAATTTTCCGAAGTTTATTAAAATA
GAACTTGGAAAACCAAGCATTTTGAATTTATTCCAGTCCTCTGGGCATCATTCCTATTTCTTCTGCCATGTCAAGGAGAAATTCCAAGCC
TGCATTCTGTCATGCTAAAATAACCAGCCCATACTTCTCGGTGACCTTCTGTTGAACGTACCTGAGCCTGCAAATGTAAAAATGATTGTA
TCTGAATCTGCACTAATGGTGTCTGAGAGCAAAAAGAGTGTGACCTCTATTGGAAACCTTTGTTCAAATTCAATAATTCAGAGATGCTAC
ATACTTCTGCAAGCTTCCTGATTATGTTCACTGTAATATTAATGACCTAAGTTTGAATGTATTTCCTTACAGTCCATTAATTTGACATCC
ATCTTTTACCTGGGGATTATTACAATTGCAATAAGTCATTAATGTTTTCTTCACACAGCTTCTTAAACCAAGTTTCTCTGCAGCTCTTTC
GGTTCTGCTTACAGTGTGTGGGAAATCTGATTTTTTTCCCCTAGTAATAGTTTGATAAGAAATTTAGTGTATTGACTGCCTCAGTGACAC
AATTTATCTTTAAAGGTGTGGAAGCTGGTGGGGACCAAATGTTACCTGTGTTTTTGCTGTTGATTGCTATTTTCAGAAGCAAACCATGTT
TTTCACTTACAGTAGGAGTCAACAAATTTGGGATTTTAGAAGGGGGAGGAGGGAGCTATTTGTGTAAGACTGCTGTCATATTTGACTACA
TATTAAAAACAGTAAATGAGCATTTTGTTTTAATTTCTTAAATACCTTGTCTTTCAACATACGTTTTGTTTCCTTTCTTCCATTAGTGTT
CAAAAGGTTCTACCCATTGTGGAAGAAATTCTGTGTGCAGAATTCAGAGGCACAAGGCTGATGGCAAGATAGAAAGTTATTTTGCTTCTA
AACCCACCCCGATGTGGAAACTGATACTAGCTAGAGGGAGCTGTAGAAAACAAAGATTTCAGGATTGCACAGTGTGTGGGCAATGGGATG
GAGACTTTTTCCCCTATTCCCAGCCACAGTGCCCAAGCGTTCAAGTCTCCTGGATCAGACAGATGGGATTTTAGCTGCTGCTTTAAATCC
TAGTGCTGGAATAAGTCAAGGTACTTCAGTTCAGCTCTTGCCTCTGTCACTAATCTTGCTTTATGAACTCCTTTGATTTTCTGAATAAGT
TCCAGAAGGTTCTCTATTATTCTGTCCTTCTTCCAAACTGGAAATGGCTGTATCTAATTCTCAGGATATTTTGGATGTGTGCCTCAGGTA
ATTTATGTGGAATGTGTAAAGCAAGATGTCTCCAATTCTGAATATTCCTTCCCCTTTTCCCAATCCTCCACTCTTGGACTACCTTTATAA
CAACACCGAGTACGCACAGACCTGAACCCATGCCCAAGAAGCACACACAATGACTGGAGCTGTCGGGAATTCCTGTCAGTGGCATTCCCT
GAGCACTGGCTCTGTACAACTCAATTATAATTTTTTAAGAATCATACCTCTGTATAGATCTTTTGGACTGTACTGATTAAACTTTGATAT

>85445_85445_1_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000313311_PLXDC2_chr10_20568632_ENST00000377252_length(amino acids)=168AA_BP=
MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVY

--------------------------------------------------------------
>85445_85445_2_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000376603_PLXDC2_chr10_20568632_ENST00000377252_length(transcript)=10996nt_BP=842nt
AGGTTGCCCGGGAGACGCGGGTACACAGAGAAGCGGCTCCCGTCGGAGGCCGAGTCGTCGCCACGATCGCCCCCTTGGTGGACTCGCAGG
CCGAGCGGCTTCCCCGCAGAGCTCGAGGAGGGCAGACGGCGGCGGGGGCGCCATGAGTCAGAGGCAGGTGCTGCAAGTGTTCGAGCAATA
CCAGAAGGCCAGGACCCAGTTCGTGCAGATGGTGGCGGAGCTGGCGACTAGACCCCAAAACATCGAGACGCTGCAGAACGCGGGTGAGCC
CGGAGCCCGAACCCCCGTCGCCCCCCGCGCACTGAGTCCCCGACGCCTCCGCCCCGCTGCCCTGCCCGTGGAGCTCTTGGGGAGCCGCAG
TGTGGGGACCGGAGTTCGCAAAAGCATCCATTCTTTTCAGCGGGTCTTTGGGGGTCAGGCCGAGAGGGTGAAGCTTCCAGATGGTTGTGG
GAGGTGCGCGTTGTCCCTGTTTCCATCTTCATTGCACACAGGTGTAATGTCTTTGCTGAGAACTCTTCTTCTGGACGTGGTCCCAACAAT
TCAACAGACTGCTGCTTTGGCTCTTGGGAGACTGGCCAATTATAATGATGACCTAGCAGAAGCTGTTGTGAAGTGCGACATTCTTCCACA
GCTTGTTTATTCATTGGCAGAACAGAATCGCTTCTACAAGAAAGCAGCTGCCTTTGTGTTACGAGCAGTTGGTAAACATTCTCCCCAGCT
AGCTCAGGCAATAGTCGATTGTGGAGCACTGGATACGCTGGTCATATGCTTGGAAGATTTTGACCCTGGAGTCAAGGAGGCTGCAGCCTG
GGCACTTAGATATATTGCAAGACATAATGCAGAGACGCCCAAGCAGATGGCCTGCGATGAAGTTTAGAAGAGGCTCTGGACATCCTGCCT
ATGCTGAAGTTGAACCAGTTGGAGAGAAAGAAGGCTTTATTGTATCAGAGCAGTGCTAAAATTTCTAGGACAGAACAACACCAGTACTGG
TTTACAGGTGTTAAGACTAAAATTTTGCCTATACCTTTAAGACAAACAAACAAACACACACACAAACAAGCTCTAAGCTGCTGTAGCCTG
AAGAAGACAAGATTTCTGGACAAGCTCAGCCCAGGAAACAAAGGGTAAACAAAAAACTAAAACTTATACAAGATACCATTTACACTGAAC
ATAGAATTCCCTAGTGGAATGTCATCTATAGTTCACTCGGAACATCTCCCGTGGACTTATCTGAAGTATGACAAGATTATAATGCTTTTG
GCTTAGGTGCAGGGTTGCAAAGGGATCAGAAAAAAAAAATCATAATAAAGCTTTAGTTCATGAGGGATCGACACCTTTGGTTCAAATGTT
CTCTGATGTCTCAAAGATAACTGTTTTCCAAAGCCTGAACCCTTTCACTCAAAAGAGCAATGATGAATGTCTCAAGATTGCTAAGAAAAA
CAGCCCATGCAAGAGTGAGAACAAACACAAAATAAGAGATTTTCTACATTTTCAAAACAGATGTGTGGCAAAAGGATGTTGTTTTTCTGG
TCTAGATCCATCTGTACCAACAAGTTCATCACTTTACAGAACGAATCTTTTTATCCGTACAGGAGGTTCAAACCATGTCTGCCTCTTCCT
TTGTAATGAATGACCTTTCTATGAGCTGTGACAAAATTTCCGAACAATTAACTAAGGATTTGGGAAGAGGGGGTGGCAAACGGGGCTTTC
TGTTTTCCTGCCTCAGCATGAAAACATCTGATTTATGCTTTATGGAAGCCTTACCTCCAATCCCCAACTGTTAAGTCCCATGAAACCACA
GTTGCTCTGGGCTGATGGAAACAAAAGGAAACAGTATGAAGAGTTCCTTAATCATTTTTGAAACAAAAATGTTAAGGGATTTTAAACATA
TGATTATTTTTAATTTTATGCCTTTTCAGTACTAAACACCCATTTCATTGCTGATTCCTGTCTAAGAAGCCATTCACGTCAGCATGGCGA
TAGAAAGAATGAAAAAACCCTGCTGAATCATACAGTAATTTTCTTTAAAGCACATAGTAGTTACATAAATATATATATATAAATATATTT
TTGTTTATAACTAACACAAGGCAGGATCTTGTGACTCTAAGAGTGCGTTTTGTCATCAAGGCAAAACAGATGCAAGATGCATCACTGCAT
TACTTCCATAGAGTTGTAAAATAATCCTTAATATTAGAATATTTTTCTGTCACTTAGCAAAAGTGGTTCAGTTCATTGCCGCGCCCATCA
TGTTCTTGACTATTTGATCCACTTTTTCGTTTATGTCAACCCCTTCCCTCTCTGGCTAAATAAAGTGGATGCAGAAAGCTCCTTAAATGG
AGATATCGATTGCCTTGGAATCACAATCCTGATTTTGAAAATTCCTCATGAATGAAGAAAGGAATGGCATCCCTTGAGAAGGAAAGTGGT
TAATATACATACTGAGCTCCTAAAGTTTAAATTCAGGTACTGAGTGTACAATTTCACCAACATTCTAACCCATGAAACTTTTACACTCTG
TGCCAAGAAACTGTTGGCTTTTGTAAGGTACAGTGCTCAACATTTGCAGATTCAGGTCTCAAGAAGCAGAGATGTCTCATAAGCAGCATT
TTCCCAACAGTTTAGCATCTGTACACATCTGCCTTGGTCATCAGTCCACTCACAGAGTACCATACTTTATCATCACAAGTGTCTGACGTG
AACGAATGCCATTTTCTATTCCATATATTTTGCTTTACAATTTTAAGTATTTGATGAAGATGGTAACTTTTTCCTAACTTAGTTAACTAT
TAAAAAAAATTTTGAAAAGCAAGGTGATTGAAGGATTGTGATGACAATCTCTTTGCAGCAGCTATGTATGGTTTATGTGAAGTATCCCCA
CTTATTCTTGTGGAGCAGGTTTGGTGAGACAGCAATAACCAAATGACATGCCAATATTACTGGTGCAACTGGTATTCTACAAATGCATAA
GGAACACATAGACGACTTCCTTTTAGGATAAAATGATGCTTCTTTCACTACCTTTTGTGGTAGCTGTGGCTTCCAATAGCAACTGTTTGA
CAGTTATATAAATCTTGCATGTGTATTCTTAGTTTGTGTCCCTTAAGTACTACTTAATTCTCAAGTAGTAATGTTATTCTTATACCCTTC
AGCGTTCTATTTTGATTCAAAACAATTGATTCAAAACAATTTTGAATCAATTTTCTATTTTGATTCAAAACAATTGATAATTCTGTAAAA
AAACATAAACACTGAATTCTTCAGTGAACCAAAGCAACAAATAATAGAGAAAACTTCTTGAAACTGGAGTGTGGGAAAACTTCTTAACAG
AACTAAGAGTTAAAGGTAGTGAGAAGTGTGTGGTGTGTGAATTCTTTAGTGGTAAGGGGAAATGTGGGCTAAATCCTTTTCTTTCATGAA
ACTCTCATTCTATTTTATATTTCTGGTTTGTTCTTGTTCCCATGTGAGAAAACATACAGTTTCTGAAAATTCAAAATGGTCATCAATGCT
TTGGACTTTACATAATTATGTATTAGAGAAGGTGCAACTGTACATTACTTAATATACTATGAACATAATAGAATAACAAAAAAAGATAAC
AAAGAGATGCAAACTTCTGGATAAATCAGATAAATGGTGCTACAGAGGAATTTAGTTATTTCAGCTTAATTATTTGTAAAAATAATAATC
AGTGACTAGGTAAAGATACTGAAACTCAAGAAAAATATCTTGACCCATTTATGTCTAGTGTTCCATTATTGGAACGCTAAGCTTATGGGA
GTTATTTAGAGCCTACTGCTCAAGGTCATCACCAAGGTCTGGTTGCAAAAATTCAAAAAATTGCAACCTCAGGCATAAATGGCTTAAGCC
CAAGAGATGGCACTGACCATAAATGGTGGCTTGTGTGTGAAGGGTTTGGACTTCAAGATATACTAACACCTAGAAAACTAAAAGTGCAAT
TGACCCCCAATTACTATTTTAGTTTGAGGTATCAAGGGCATTTGCCAATCTCTTATATGTAGCTTCTAGAGTTGTGCTGTCCAATATTAT
ATCCACTAGCCAACGTGGCTTTTGAAATTAAAATTAATTAAAATTAAATTAAAAATGTAATTCTTCAGTCACACCAGCCACATTTCAAAG
GCTCAATAGCCACGCCTGGCTTGTGGCTACCATATTGGATAACAAGAAACACTTCCGTGGTTGAAGAAAATTTTAATGGACAATGCTGTG
TTTCATTTGAATTCGTTGTCCTTGAAGAAAAGGGAAGAAGAGGAAAGAAACAAGATTTGGTAGCTCTTGGGCATATCCAAGCATTTTTGA
TTTTAGAGAGGCCCTATGGAGTAATGAAAAAAATACAAGCTGACACAGCTTTAAATCCCCACTGTGTTATCTTGGGAAAATCACTTCAAC
CTCCTTGAGTCTCAATTTGCAATTTTGGAAAAGAAAAACAATTTTTGTCCTGTCTTTCTTGCAAGATTATTATGCAACCTGATTAAATGT
ACAGATGTGCAGACTCTTAAAAACCTTATGTTAATGTAACCCATATAAAGTACGACTTTTGGTCGAGTACCAGCACAAATTTGCATTCAA
AGGAAGAATAGTTCATCAGTGCAAAAAGCGTTCAAAGGTAATCAGTTCATCACGTATCTTGAGAAAAAGAGAATGCATTCAAAACACAAA
GCAAAATTGCTTCAGTTTCTTTTCTGCCCATCTGAATATTTCCTTTAGTATTTGTCCCACATGACATCCATCCCATGTATTTATCCACTC
TTTCACAACATTGCCTATGAACATCCTTCAACTGGCTCAGTTCTTTATTGCATAGAGCCACTTAGCTTCTCTAGTTTCTTATGATTTCCT
ATTTTACACTTAACAGCAAAAGGAGGCTTCCATTTAGAAGGCACTATCTCAAACATAAATAATTTCATATTTATTTTATCACTGTAACAC
TAAGGAGCTATGGCATTAAAATATAAAACTATTTGGAACTTAATGTAAACCTTTGCACATGCAGACTATATAAAGGGAATAAAATTATTT
TAAATTATGCTAATATCCAGATACATATTCTAAGGTTAGTATCATTTATCAGTTTTTCGCAACAGATTCTTATGTTACATCTTCATGAGG
GAGTATAAATTTGATCACGTCCCTAGTGTCTATTGCCCACTTGAGAAAGGTTTTGCCAGGATCCACAGATCGCTTCAAGATGCTTTCGTT
TATGATAGGAAATTAATATTTAAATAAGACTAATTGAAAACTAGATTATCTGGTTCTAATTTCTTCCTCCTGTGAAATGTTCTTTTGGTT
TGTATTTCTTTAGGTATTTTCCAAGTTACTGCTGCTTTTACTTCACGACCTCCAACCCCACTTTTGTTATCAGCGTCATATGCCAGAGTC
ATGGCAGATCCAGCCTGGACAACATAGTGAGACCCATCTCTATCAAATATACATATATATATATATATATACACACACACACACACACAC
ACAAATATACATATATATCAAATATATATGTATATTTGATAGAGATGATAGCAATTATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
TAGCCAAGTGTGGTTTCTCATGCCTGTAGTCCCAGCTACTTTGGAGGCTGAAGTGTAAGAGTTGCTTGAGCCCATGAGTTAGAGGCTGCT
GTGAGCTATGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAAACCCCATCTCTAAATAAAAAAAAAGAATCGTGAGACATCATG
TAATCCAACCTCTTAATGTTACAGATAAGTAAACTGAGGCCCAAAGAGATATAGTAATAGTCCCAGTGTCAGTAAACTGGGTCTTGAACT
TAAATGTTTGTTTCAGTTCTCATTGCCTTCATCTCTTAATTGTCGGCACTTAAGGCCAACCAAGCAGCTTAGACAGCGCAGTCCACTCAA
CGGTAACTTTATTTGCTATATTGACAATCTGCTCTGTTCTGTAATATAGAACATTGGATCAATCTTTATCTTTTTGCTGACTTAAGGAGG
CTGCTATTGTTGCAATATCCAGAGATTTCAAGTTCTAGCCATTGCGGGGTCTTTGTGGTGTTTTCAATTTCTCCTCTCTCCACCCCTGCC
CCCATCTGTGGCCATCTAAGTTAGCAATACAATTTATTTTGGCCATTTAAAATTTTTCTGCCTTTGTTTTATTTCTTCCCAAATATATTT
GAAAATGAATGATCTATATAGCTGATTTTCTGACCACATATATAATTGCAATTTTTATTTGCTCTTCAAACTATTACAACATTTTTGTCC
TTATAAGGTTTTTTGGGCAGATAATGCGAGGTCTGTGGTGTTACCTTTTATATACTCCTATTACCTTATGTTTGTGAAGCATTTTACATT
TTACAGAGCACTTTGATTCATCTCCCTATTTGTTCATTTATTTAACTGTTCAGTTCACTGAAATATTTATTGAACACCTACTGGAACCAA
GTGACTGTGCTAGTAACTTGTGATATACAGTAGTGAGAGTCCAGGCATGTAACCGATCATTATAATACAATAACATCCCTAAACCAGACT
TTACAAGTAGATAGGATCAACAATACTCTATCAATTTTCAACTCCAATTTTCTATTCTACTTAAAATGGGAACTAGAAACTGTTTGCCTG
AAGAATGTGTCTGAAACATAATATATCACTGCATGTCTGTGCTGTAGACCTGTTAATTTTATCTGTGAGAAAAAAAGTTACTCAAAATTC
TCCCTGACCTAAGAATACTTTCTAGTTCACTGCAGTCTTACTGACCAGATGCAACAGTTGAAGTTTGATTTCTCGACCCAATATTTCTAT
TGGGTTTTGAATTATTAATATCACTGTTTTGAGGTATTCAGAAACACCAGTGTATCAAAAAAGCATTTGCACTTTAGGTGTGTGTGGTGG
TTATGTCATTTATTAGACCATCCCAGACATAAGACAATCAGGGAAATCAGAAAACTCCAGCCTCAAATGTGTCTATAATTTCCTGTTCTA
CCATTGTCATATCATAACATGGTATTACTTCTTAAGGTTTTGATTAAGTTGATCTAGCCTCAACTTAAATTGTAATACATCTGCCTAATT
ATTGTCTGGAATAACTTTTCAACCATCCAATGCCCACTGCTCTCACAATGATTATTGTAGAGAAGTAAAATGGTAATTATTCAAGTAAAG
TCACATAATTTCTGGAGTCAGTTTTTCATAACAAGTTTATGGAATACATCATCATTGGCTTCTTCATAATATATTTATTATGAGTGACCA
AATTTTGCCTGGAGGAGCAAAATGCTCAAAACTTGTTATTATAGGTTAATTTCCAGCTCACTGTTGACACTGAAAGATTCTGTGTTACTT
TAAACCCAGGATAAAAGGCTGGAAAAAAAATTAAATGTAAGTCATAAACTAGTACTCAGCTTTTCCTAGTTTCTAAGGCTTATTAACATT
TGCAAATTACTCAATAAATGTCTTTCATAATGGAATAACATAAAAGCTTTTGATTTGGCAGATAGTGATATTTTATTTATTTTCATTCTG
GTTGAAAAAAATCTCAGTGGCTTCTCTTCATTCCACGAGAATTTTGATTTTTAACAGCAGTCTCTCTTTTTCTCAGCATTGCAAATATAT
ATGTATATATACATTCATGACCAAAGTATCGCTTACTGACCATGCAGCTGTAAACCTTCTGTGCCTATCAAACAAATACATAGCATGAAA
CTAATTTTAGAAGTTTCATGGGGGAATTTTAGGGGAAAGTATAAACCTAAGAGTGAGTGAATGGAGATGATTCATGGAAAAAAAAATAAA
AATCTAAATGTGCTATTAGGCAGAGTTATTAACTTCTTTTAGTTGTTGTTTGAGATGGGGTTTTGCTCTTGTTACCCAGGCTGGAGTGCA
ATGGCGTGATCTCGTCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCGCCCAAGTAGCTGGGATTACAGGCA
TATGCCACTACAGCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGCTGGTCAGGCTGGTCCCCAGCTCCCGACCTCAGG
TGATCCGCCCACCTCCGCCTCCCAAAGTGCTGGAATTACAGGCCTGAGCCACCGTGCCTGGCCGAGTTATTAACTTCTTAAGAGCAATGT
GCTAATAAATACTCATTGATGACCAGCTCAAATTTAGGTCATTCAGACATCCAGACACTGGGGCACATATTCTGCAAGCAATGCTGAGAC
CCCTGACATAGAGAAAGCAAAGGATATGCCTATGATTAGTCTAAAATGCAGCCATCACCCCCCATACCTCTTCTATGGCATTCATCCTAA
CATCATGGAGGCCTTTGTCCTAGAGAATTATGTGACTTGCCCTAGAGAATTAGTGAATGACCAAAAAGAGACTTTCCATTTATCTTCCTT
TGACTTAAAAGGCATGAAAATAAGGCAAAAAAATCAATAAAATAATTTTCCTGAGGAAAGGTTAAGAGATGGCACTTTCCTTTCCGGGCC
CAGAGCTGGATTTCTCTGAGATTTGACCATCTCAGGACTCAGACAGACTCCAGTGCTATTTTCTGGACATTTGTGGTGAAGCCTCAGCCA
CCATGTTCAAGGTGGTTTGAATGAAAACATACTCAGATTGTCACATTTATAGCAGGGAAATAAAAACTCAAATTAGGCATCCTGCAGCAG
GCTACTCTGAAAATAACATTAGGCAACATCAGAGCTTCACTTGCAAAGAAATGTTAAAATCATTTTAGGGAAATCAGTGAAGTCTCTTTA
GAAACAGACATCTTGTGTATGGCGTAACCCAGTCTTGGGGCCCTCACGGAGAAGAGGGGGAAGTCTTTTCATTGATTGGTCAAAACAAAT
CTCTCATTTGCCTGATTTGAAGCATTTCAACAGTGCCTGGAGAGTACATTATTTTCAGGGGAAAAAAAGGAGAGAGTCTTTTTTATATGC
CAGCTGGGATCATGGGAACTTCGAATGCCAGGAATTTACTACTGTTTCTGGTAATTCTGTGTGTAGTCATTTGAAATGTTGAAGTGTGAA
AAGAGAAGAAATTGGGCACTTCTTGCGGCGGGGGAGGGGGGGGGGGCGGTGGCTTTCCAGATTTTATGCCAGTTGCACCAGCATGCAGAA
TATTTGTAATGCATTTCAAAGTGGATATAATGGCACCCTTTGTCAGAATCACAAAGCTCACTGCGGCACTGCTACAAGAGGACACTGAGG
AAAATCTGGCCCTATGAACCTAGTCAACCCCAAGCAAAAAGAATGACTATGTGTGTGAGTGCAGCACATGGCCAGTTCGTTTCTCACTGT
TTTGGAAAGCCCTGTGTGCCAAACCAAGGACGTGTCTTTCAGGGAAAGGTTAATTTTCCGAAGTTTATTAAAATAGAACTTGGAAAACCA
AGCATTTTGAATTTATTCCAGTCCTCTGGGCATCATTCCTATTTCTTCTGCCATGTCAAGGAGAAATTCCAAGCCTGCATTCTGTCATGC
TAAAATAACCAGCCCATACTTCTCGGTGACCTTCTGTTGAACGTACCTGAGCCTGCAAATGTAAAAATGATTGTATCTGAATCTGCACTA
ATGGTGTCTGAGAGCAAAAAGAGTGTGACCTCTATTGGAAACCTTTGTTCAAATTCAATAATTCAGAGATGCTACATACTTCTGCAAGCT
TCCTGATTATGTTCACTGTAATATTAATGACCTAAGTTTGAATGTATTTCCTTACAGTCCATTAATTTGACATCCATCTTTTACCTGGGG
ATTATTACAATTGCAATAAGTCATTAATGTTTTCTTCACACAGCTTCTTAAACCAAGTTTCTCTGCAGCTCTTTCGGTTCTGCTTACAGT
GTGTGGGAAATCTGATTTTTTTCCCCTAGTAATAGTTTGATAAGAAATTTAGTGTATTGACTGCCTCAGTGACACAATTTATCTTTAAAG
GTGTGGAAGCTGGTGGGGACCAAATGTTACCTGTGTTTTTGCTGTTGATTGCTATTTTCAGAAGCAAACCATGTTTTTCACTTACAGTAG
GAGTCAACAAATTTGGGATTTTAGAAGGGGGAGGAGGGAGCTATTTGTGTAAGACTGCTGTCATATTTGACTACATATTAAAAACAGTAA
ATGAGCATTTTGTTTTAATTTCTTAAATACCTTGTCTTTCAACATACGTTTTGTTTCCTTTCTTCCATTAGTGTTCAAAAGGTTCTACCC
ATTGTGGAAGAAATTCTGTGTGCAGAATTCAGAGGCACAAGGCTGATGGCAAGATAGAAAGTTATTTTGCTTCTAAACCCACCCCGATGT
GGAAACTGATACTAGCTAGAGGGAGCTGTAGAAAACAAAGATTTCAGGATTGCACAGTGTGTGGGCAATGGGATGGAGACTTTTTCCCCT
ATTCCCAGCCACAGTGCCCAAGCGTTCAAGTCTCCTGGATCAGACAGATGGGATTTTAGCTGCTGCTTTAAATCCTAGTGCTGGAATAAG
TCAAGGTACTTCAGTTCAGCTCTTGCCTCTGTCACTAATCTTGCTTTATGAACTCCTTTGATTTTCTGAATAAGTTCCAGAAGGTTCTCT
ATTATTCTGTCCTTCTTCCAAACTGGAAATGGCTGTATCTAATTCTCAGGATATTTTGGATGTGTGCCTCAGGTAATTTATGTGGAATGT
GTAAAGCAAGATGTCTCCAATTCTGAATATTCCTTCCCCTTTTCCCAATCCTCCACTCTTGGACTACCTTTATAACAACACCGAGTACGC
ACAGACCTGAACCCATGCCCAAGAAGCACACACAATGACTGGAGCTGTCGGGAATTCCTGTCAGTGGCATTCCCTGAGCACTGGCTCTGT
ACAACTCAATTATAATTTTTTAAGAATCATACCTCTGTATAGATCTTTTGGACTGTACTGATTAAACTTTGATATTGTGGAGTAAATTCA

>85445_85445_2_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000376603_PLXDC2_chr10_20568632_ENST00000377252_length(amino acids)=244AA_BP=
MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGEPGARTPVAPRALSPRRLRPAALPVELLGSRSVGTGVRKSIHSFQRVFG
GQAERVKLPDGCGRCALSLFPSSLHTGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAA

--------------------------------------------------------------
>85445_85445_3_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000376624_PLXDC2_chr10_20568632_ENST00000377252_length(transcript)=10768nt_BP=614nt
AGGTTGCCCGGGAGACGCGGGTACACAGAGAAGCGGCTCCCGTCGGAGGCCGAGTCGTCGCCACGATCGCCCCCTTGGTGGACTCGCAGG
CCGAGCGGCTTCCCCGCAGAGCTCGAGGAGGGCAGACGGCGGCGGGGGCGCCATGAGTCAGAGGCAGGTGCTGCAAGTGTTCGAGCAATA
CCAGAAGGCCAGGACCCAGTTCGTGCAGATGGTGGCGGAGCTGGCGACTAGACCCCAAAACATCGAGACGCTGCAGAACGCGGGTGTAAT
GTCTTTGCTGAGAACTCTTCTTCTGGACGTGGTCCCAACAATTCAACAGACTGCTGCTTTGGCTCTTGGGAGACTGGCCAATTATAATGA
TGACCTAGCAGAAGCTGTTGTGAAGTGCGACATTCTTCCACAGCTTGTTTATTCATTGGCAGAACAGAATCGCTTCTACAAGAAAGCAGC
TGCCTTTGTGTTACGAGCAGTTGGTAAACATTCTCCCCAGCTAGCTCAGGCAATAGTCGATTGTGGAGCACTGGATACGCTGGTCATATG
CTTGGAAGATTTTGACCCTGGAGTCAAGGAGGCTGCAGCCTGGGCACTTAGATATATTGCAAGACATAATGCAGAGACGCCCAAGCAGAT
GGCCTGCGATGAAGTTTAGAAGAGGCTCTGGACATCCTGCCTATGCTGAAGTTGAACCAGTTGGAGAGAAAGAAGGCTTTATTGTATCAG
AGCAGTGCTAAAATTTCTAGGACAGAACAACACCAGTACTGGTTTACAGGTGTTAAGACTAAAATTTTGCCTATACCTTTAAGACAAACA
AACAAACACACACACAAACAAGCTCTAAGCTGCTGTAGCCTGAAGAAGACAAGATTTCTGGACAAGCTCAGCCCAGGAAACAAAGGGTAA
ACAAAAAACTAAAACTTATACAAGATACCATTTACACTGAACATAGAATTCCCTAGTGGAATGTCATCTATAGTTCACTCGGAACATCTC
CCGTGGACTTATCTGAAGTATGACAAGATTATAATGCTTTTGGCTTAGGTGCAGGGTTGCAAAGGGATCAGAAAAAAAAAATCATAATAA
AGCTTTAGTTCATGAGGGATCGACACCTTTGGTTCAAATGTTCTCTGATGTCTCAAAGATAACTGTTTTCCAAAGCCTGAACCCTTTCAC
TCAAAAGAGCAATGATGAATGTCTCAAGATTGCTAAGAAAAACAGCCCATGCAAGAGTGAGAACAAACACAAAATAAGAGATTTTCTACA
TTTTCAAAACAGATGTGTGGCAAAAGGATGTTGTTTTTCTGGTCTAGATCCATCTGTACCAACAAGTTCATCACTTTACAGAACGAATCT
TTTTATCCGTACAGGAGGTTCAAACCATGTCTGCCTCTTCCTTTGTAATGAATGACCTTTCTATGAGCTGTGACAAAATTTCCGAACAAT
TAACTAAGGATTTGGGAAGAGGGGGTGGCAAACGGGGCTTTCTGTTTTCCTGCCTCAGCATGAAAACATCTGATTTATGCTTTATGGAAG
CCTTACCTCCAATCCCCAACTGTTAAGTCCCATGAAACCACAGTTGCTCTGGGCTGATGGAAACAAAAGGAAACAGTATGAAGAGTTCCT
TAATCATTTTTGAAACAAAAATGTTAAGGGATTTTAAACATATGATTATTTTTAATTTTATGCCTTTTCAGTACTAAACACCCATTTCAT
TGCTGATTCCTGTCTAAGAAGCCATTCACGTCAGCATGGCGATAGAAAGAATGAAAAAACCCTGCTGAATCATACAGTAATTTTCTTTAA
AGCACATAGTAGTTACATAAATATATATATATAAATATATTTTTGTTTATAACTAACACAAGGCAGGATCTTGTGACTCTAAGAGTGCGT
TTTGTCATCAAGGCAAAACAGATGCAAGATGCATCACTGCATTACTTCCATAGAGTTGTAAAATAATCCTTAATATTAGAATATTTTTCT
GTCACTTAGCAAAAGTGGTTCAGTTCATTGCCGCGCCCATCATGTTCTTGACTATTTGATCCACTTTTTCGTTTATGTCAACCCCTTCCC
TCTCTGGCTAAATAAAGTGGATGCAGAAAGCTCCTTAAATGGAGATATCGATTGCCTTGGAATCACAATCCTGATTTTGAAAATTCCTCA
TGAATGAAGAAAGGAATGGCATCCCTTGAGAAGGAAAGTGGTTAATATACATACTGAGCTCCTAAAGTTTAAATTCAGGTACTGAGTGTA
CAATTTCACCAACATTCTAACCCATGAAACTTTTACACTCTGTGCCAAGAAACTGTTGGCTTTTGTAAGGTACAGTGCTCAACATTTGCA
GATTCAGGTCTCAAGAAGCAGAGATGTCTCATAAGCAGCATTTTCCCAACAGTTTAGCATCTGTACACATCTGCCTTGGTCATCAGTCCA
CTCACAGAGTACCATACTTTATCATCACAAGTGTCTGACGTGAACGAATGCCATTTTCTATTCCATATATTTTGCTTTACAATTTTAAGT
ATTTGATGAAGATGGTAACTTTTTCCTAACTTAGTTAACTATTAAAAAAAATTTTGAAAAGCAAGGTGATTGAAGGATTGTGATGACAAT
CTCTTTGCAGCAGCTATGTATGGTTTATGTGAAGTATCCCCACTTATTCTTGTGGAGCAGGTTTGGTGAGACAGCAATAACCAAATGACA
TGCCAATATTACTGGTGCAACTGGTATTCTACAAATGCATAAGGAACACATAGACGACTTCCTTTTAGGATAAAATGATGCTTCTTTCAC
TACCTTTTGTGGTAGCTGTGGCTTCCAATAGCAACTGTTTGACAGTTATATAAATCTTGCATGTGTATTCTTAGTTTGTGTCCCTTAAGT
ACTACTTAATTCTCAAGTAGTAATGTTATTCTTATACCCTTCAGCGTTCTATTTTGATTCAAAACAATTGATTCAAAACAATTTTGAATC
AATTTTCTATTTTGATTCAAAACAATTGATAATTCTGTAAAAAAACATAAACACTGAATTCTTCAGTGAACCAAAGCAACAAATAATAGA
GAAAACTTCTTGAAACTGGAGTGTGGGAAAACTTCTTAACAGAACTAAGAGTTAAAGGTAGTGAGAAGTGTGTGGTGTGTGAATTCTTTA
GTGGTAAGGGGAAATGTGGGCTAAATCCTTTTCTTTCATGAAACTCTCATTCTATTTTATATTTCTGGTTTGTTCTTGTTCCCATGTGAG
AAAACATACAGTTTCTGAAAATTCAAAATGGTCATCAATGCTTTGGACTTTACATAATTATGTATTAGAGAAGGTGCAACTGTACATTAC
TTAATATACTATGAACATAATAGAATAACAAAAAAAGATAACAAAGAGATGCAAACTTCTGGATAAATCAGATAAATGGTGCTACAGAGG
AATTTAGTTATTTCAGCTTAATTATTTGTAAAAATAATAATCAGTGACTAGGTAAAGATACTGAAACTCAAGAAAAATATCTTGACCCAT
TTATGTCTAGTGTTCCATTATTGGAACGCTAAGCTTATGGGAGTTATTTAGAGCCTACTGCTCAAGGTCATCACCAAGGTCTGGTTGCAA
AAATTCAAAAAATTGCAACCTCAGGCATAAATGGCTTAAGCCCAAGAGATGGCACTGACCATAAATGGTGGCTTGTGTGTGAAGGGTTTG
GACTTCAAGATATACTAACACCTAGAAAACTAAAAGTGCAATTGACCCCCAATTACTATTTTAGTTTGAGGTATCAAGGGCATTTGCCAA
TCTCTTATATGTAGCTTCTAGAGTTGTGCTGTCCAATATTATATCCACTAGCCAACGTGGCTTTTGAAATTAAAATTAATTAAAATTAAA
TTAAAAATGTAATTCTTCAGTCACACCAGCCACATTTCAAAGGCTCAATAGCCACGCCTGGCTTGTGGCTACCATATTGGATAACAAGAA
ACACTTCCGTGGTTGAAGAAAATTTTAATGGACAATGCTGTGTTTCATTTGAATTCGTTGTCCTTGAAGAAAAGGGAAGAAGAGGAAAGA
AACAAGATTTGGTAGCTCTTGGGCATATCCAAGCATTTTTGATTTTAGAGAGGCCCTATGGAGTAATGAAAAAAATACAAGCTGACACAG
CTTTAAATCCCCACTGTGTTATCTTGGGAAAATCACTTCAACCTCCTTGAGTCTCAATTTGCAATTTTGGAAAAGAAAAACAATTTTTGT
CCTGTCTTTCTTGCAAGATTATTATGCAACCTGATTAAATGTACAGATGTGCAGACTCTTAAAAACCTTATGTTAATGTAACCCATATAA
AGTACGACTTTTGGTCGAGTACCAGCACAAATTTGCATTCAAAGGAAGAATAGTTCATCAGTGCAAAAAGCGTTCAAAGGTAATCAGTTC
ATCACGTATCTTGAGAAAAAGAGAATGCATTCAAAACACAAAGCAAAATTGCTTCAGTTTCTTTTCTGCCCATCTGAATATTTCCTTTAG
TATTTGTCCCACATGACATCCATCCCATGTATTTATCCACTCTTTCACAACATTGCCTATGAACATCCTTCAACTGGCTCAGTTCTTTAT
TGCATAGAGCCACTTAGCTTCTCTAGTTTCTTATGATTTCCTATTTTACACTTAACAGCAAAAGGAGGCTTCCATTTAGAAGGCACTATC
TCAAACATAAATAATTTCATATTTATTTTATCACTGTAACACTAAGGAGCTATGGCATTAAAATATAAAACTATTTGGAACTTAATGTAA
ACCTTTGCACATGCAGACTATATAAAGGGAATAAAATTATTTTAAATTATGCTAATATCCAGATACATATTCTAAGGTTAGTATCATTTA
TCAGTTTTTCGCAACAGATTCTTATGTTACATCTTCATGAGGGAGTATAAATTTGATCACGTCCCTAGTGTCTATTGCCCACTTGAGAAA
GGTTTTGCCAGGATCCACAGATCGCTTCAAGATGCTTTCGTTTATGATAGGAAATTAATATTTAAATAAGACTAATTGAAAACTAGATTA
TCTGGTTCTAATTTCTTCCTCCTGTGAAATGTTCTTTTGGTTTGTATTTCTTTAGGTATTTTCCAAGTTACTGCTGCTTTTACTTCACGA
CCTCCAACCCCACTTTTGTTATCAGCGTCATATGCCAGAGTCATGGCAGATCCAGCCTGGACAACATAGTGAGACCCATCTCTATCAAAT
ATACATATATATATATATATATACACACACACACACACACACACAAATATACATATATATCAAATATATATGTATATTTGATAGAGATGA
TAGCAATTATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTAGCCAAGTGTGGTTTCTCATGCCTGTAGTCCCAGCTACTTTGGAGGC
TGAAGTGTAAGAGTTGCTTGAGCCCATGAGTTAGAGGCTGCTGTGAGCTATGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAA
ACCCCATCTCTAAATAAAAAAAAAGAATCGTGAGACATCATGTAATCCAACCTCTTAATGTTACAGATAAGTAAACTGAGGCCCAAAGAG
ATATAGTAATAGTCCCAGTGTCAGTAAACTGGGTCTTGAACTTAAATGTTTGTTTCAGTTCTCATTGCCTTCATCTCTTAATTGTCGGCA
CTTAAGGCCAACCAAGCAGCTTAGACAGCGCAGTCCACTCAACGGTAACTTTATTTGCTATATTGACAATCTGCTCTGTTCTGTAATATA
GAACATTGGATCAATCTTTATCTTTTTGCTGACTTAAGGAGGCTGCTATTGTTGCAATATCCAGAGATTTCAAGTTCTAGCCATTGCGGG
GTCTTTGTGGTGTTTTCAATTTCTCCTCTCTCCACCCCTGCCCCCATCTGTGGCCATCTAAGTTAGCAATACAATTTATTTTGGCCATTT
AAAATTTTTCTGCCTTTGTTTTATTTCTTCCCAAATATATTTGAAAATGAATGATCTATATAGCTGATTTTCTGACCACATATATAATTG
CAATTTTTATTTGCTCTTCAAACTATTACAACATTTTTGTCCTTATAAGGTTTTTTGGGCAGATAATGCGAGGTCTGTGGTGTTACCTTT
TATATACTCCTATTACCTTATGTTTGTGAAGCATTTTACATTTTACAGAGCACTTTGATTCATCTCCCTATTTGTTCATTTATTTAACTG
TTCAGTTCACTGAAATATTTATTGAACACCTACTGGAACCAAGTGACTGTGCTAGTAACTTGTGATATACAGTAGTGAGAGTCCAGGCAT
GTAACCGATCATTATAATACAATAACATCCCTAAACCAGACTTTACAAGTAGATAGGATCAACAATACTCTATCAATTTTCAACTCCAAT
TTTCTATTCTACTTAAAATGGGAACTAGAAACTGTTTGCCTGAAGAATGTGTCTGAAACATAATATATCACTGCATGTCTGTGCTGTAGA
CCTGTTAATTTTATCTGTGAGAAAAAAAGTTACTCAAAATTCTCCCTGACCTAAGAATACTTTCTAGTTCACTGCAGTCTTACTGACCAG
ATGCAACAGTTGAAGTTTGATTTCTCGACCCAATATTTCTATTGGGTTTTGAATTATTAATATCACTGTTTTGAGGTATTCAGAAACACC
AGTGTATCAAAAAAGCATTTGCACTTTAGGTGTGTGTGGTGGTTATGTCATTTATTAGACCATCCCAGACATAAGACAATCAGGGAAATC
AGAAAACTCCAGCCTCAAATGTGTCTATAATTTCCTGTTCTACCATTGTCATATCATAACATGGTATTACTTCTTAAGGTTTTGATTAAG
TTGATCTAGCCTCAACTTAAATTGTAATACATCTGCCTAATTATTGTCTGGAATAACTTTTCAACCATCCAATGCCCACTGCTCTCACAA
TGATTATTGTAGAGAAGTAAAATGGTAATTATTCAAGTAAAGTCACATAATTTCTGGAGTCAGTTTTTCATAACAAGTTTATGGAATACA
TCATCATTGGCTTCTTCATAATATATTTATTATGAGTGACCAAATTTTGCCTGGAGGAGCAAAATGCTCAAAACTTGTTATTATAGGTTA
ATTTCCAGCTCACTGTTGACACTGAAAGATTCTGTGTTACTTTAAACCCAGGATAAAAGGCTGGAAAAAAAATTAAATGTAAGTCATAAA
CTAGTACTCAGCTTTTCCTAGTTTCTAAGGCTTATTAACATTTGCAAATTACTCAATAAATGTCTTTCATAATGGAATAACATAAAAGCT
TTTGATTTGGCAGATAGTGATATTTTATTTATTTTCATTCTGGTTGAAAAAAATCTCAGTGGCTTCTCTTCATTCCACGAGAATTTTGAT
TTTTAACAGCAGTCTCTCTTTTTCTCAGCATTGCAAATATATATGTATATATACATTCATGACCAAAGTATCGCTTACTGACCATGCAGC
TGTAAACCTTCTGTGCCTATCAAACAAATACATAGCATGAAACTAATTTTAGAAGTTTCATGGGGGAATTTTAGGGGAAAGTATAAACCT
AAGAGTGAGTGAATGGAGATGATTCATGGAAAAAAAAATAAAAATCTAAATGTGCTATTAGGCAGAGTTATTAACTTCTTTTAGTTGTTG
TTTGAGATGGGGTTTTGCTCTTGTTACCCAGGCTGGAGTGCAATGGCGTGATCTCGTCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCG
ATTCTCCTGCCTCAGCCGCCCAAGTAGCTGGGATTACAGGCATATGCCACTACAGCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTT
TCTCCATGCTGGTCAGGCTGGTCCCCAGCTCCCGACCTCAGGTGATCCGCCCACCTCCGCCTCCCAAAGTGCTGGAATTACAGGCCTGAG
CCACCGTGCCTGGCCGAGTTATTAACTTCTTAAGAGCAATGTGCTAATAAATACTCATTGATGACCAGCTCAAATTTAGGTCATTCAGAC
ATCCAGACACTGGGGCACATATTCTGCAAGCAATGCTGAGACCCCTGACATAGAGAAAGCAAAGGATATGCCTATGATTAGTCTAAAATG
CAGCCATCACCCCCCATACCTCTTCTATGGCATTCATCCTAACATCATGGAGGCCTTTGTCCTAGAGAATTATGTGACTTGCCCTAGAGA
ATTAGTGAATGACCAAAAAGAGACTTTCCATTTATCTTCCTTTGACTTAAAAGGCATGAAAATAAGGCAAAAAAATCAATAAAATAATTT
TCCTGAGGAAAGGTTAAGAGATGGCACTTTCCTTTCCGGGCCCAGAGCTGGATTTCTCTGAGATTTGACCATCTCAGGACTCAGACAGAC
TCCAGTGCTATTTTCTGGACATTTGTGGTGAAGCCTCAGCCACCATGTTCAAGGTGGTTTGAATGAAAACATACTCAGATTGTCACATTT
ATAGCAGGGAAATAAAAACTCAAATTAGGCATCCTGCAGCAGGCTACTCTGAAAATAACATTAGGCAACATCAGAGCTTCACTTGCAAAG
AAATGTTAAAATCATTTTAGGGAAATCAGTGAAGTCTCTTTAGAAACAGACATCTTGTGTATGGCGTAACCCAGTCTTGGGGCCCTCACG
GAGAAGAGGGGGAAGTCTTTTCATTGATTGGTCAAAACAAATCTCTCATTTGCCTGATTTGAAGCATTTCAACAGTGCCTGGAGAGTACA
TTATTTTCAGGGGAAAAAAAGGAGAGAGTCTTTTTTATATGCCAGCTGGGATCATGGGAACTTCGAATGCCAGGAATTTACTACTGTTTC
TGGTAATTCTGTGTGTAGTCATTTGAAATGTTGAAGTGTGAAAAGAGAAGAAATTGGGCACTTCTTGCGGCGGGGGAGGGGGGGGGGGCG
GTGGCTTTCCAGATTTTATGCCAGTTGCACCAGCATGCAGAATATTTGTAATGCATTTCAAAGTGGATATAATGGCACCCTTTGTCAGAA
TCACAAAGCTCACTGCGGCACTGCTACAAGAGGACACTGAGGAAAATCTGGCCCTATGAACCTAGTCAACCCCAAGCAAAAAGAATGACT
ATGTGTGTGAGTGCAGCACATGGCCAGTTCGTTTCTCACTGTTTTGGAAAGCCCTGTGTGCCAAACCAAGGACGTGTCTTTCAGGGAAAG
GTTAATTTTCCGAAGTTTATTAAAATAGAACTTGGAAAACCAAGCATTTTGAATTTATTCCAGTCCTCTGGGCATCATTCCTATTTCTTC
TGCCATGTCAAGGAGAAATTCCAAGCCTGCATTCTGTCATGCTAAAATAACCAGCCCATACTTCTCGGTGACCTTCTGTTGAACGTACCT
GAGCCTGCAAATGTAAAAATGATTGTATCTGAATCTGCACTAATGGTGTCTGAGAGCAAAAAGAGTGTGACCTCTATTGGAAACCTTTGT
TCAAATTCAATAATTCAGAGATGCTACATACTTCTGCAAGCTTCCTGATTATGTTCACTGTAATATTAATGACCTAAGTTTGAATGTATT
TCCTTACAGTCCATTAATTTGACATCCATCTTTTACCTGGGGATTATTACAATTGCAATAAGTCATTAATGTTTTCTTCACACAGCTTCT
TAAACCAAGTTTCTCTGCAGCTCTTTCGGTTCTGCTTACAGTGTGTGGGAAATCTGATTTTTTTCCCCTAGTAATAGTTTGATAAGAAAT
TTAGTGTATTGACTGCCTCAGTGACACAATTTATCTTTAAAGGTGTGGAAGCTGGTGGGGACCAAATGTTACCTGTGTTTTTGCTGTTGA
TTGCTATTTTCAGAAGCAAACCATGTTTTTCACTTACAGTAGGAGTCAACAAATTTGGGATTTTAGAAGGGGGAGGAGGGAGCTATTTGT
GTAAGACTGCTGTCATATTTGACTACATATTAAAAACAGTAAATGAGCATTTTGTTTTAATTTCTTAAATACCTTGTCTTTCAACATACG
TTTTGTTTCCTTTCTTCCATTAGTGTTCAAAAGGTTCTACCCATTGTGGAAGAAATTCTGTGTGCAGAATTCAGAGGCACAAGGCTGATG
GCAAGATAGAAAGTTATTTTGCTTCTAAACCCACCCCGATGTGGAAACTGATACTAGCTAGAGGGAGCTGTAGAAAACAAAGATTTCAGG
ATTGCACAGTGTGTGGGCAATGGGATGGAGACTTTTTCCCCTATTCCCAGCCACAGTGCCCAAGCGTTCAAGTCTCCTGGATCAGACAGA
TGGGATTTTAGCTGCTGCTTTAAATCCTAGTGCTGGAATAAGTCAAGGTACTTCAGTTCAGCTCTTGCCTCTGTCACTAATCTTGCTTTA
TGAACTCCTTTGATTTTCTGAATAAGTTCCAGAAGGTTCTCTATTATTCTGTCCTTCTTCCAAACTGGAAATGGCTGTATCTAATTCTCA
GGATATTTTGGATGTGTGCCTCAGGTAATTTATGTGGAATGTGTAAAGCAAGATGTCTCCAATTCTGAATATTCCTTCCCCTTTTCCCAA
TCCTCCACTCTTGGACTACCTTTATAACAACACCGAGTACGCACAGACCTGAACCCATGCCCAAGAAGCACACACAATGACTGGAGCTGT
CGGGAATTCCTGTCAGTGGCATTCCCTGAGCACTGGCTCTGTACAACTCAATTATAATTTTTTAAGAATCATACCTCTGTATAGATCTTT

>85445_85445_3_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000376624_PLXDC2_chr10_20568632_ENST00000377252_length(amino acids)=168AA_BP=
MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVY

--------------------------------------------------------------
>85445_85445_4_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000538630_PLXDC2_chr10_20568632_ENST00000377252_length(transcript)=11123nt_BP=969nt
AGGTTGCCCGGGAGACGCGGGTACACAGAGAAGCGGCTCCCGTCGGAGGCCGAGTCGTCGCCACGATCGCCCCCTTGGTGGACTCGCAGG
CCGAGCGGCTTCCCCGCAGAGCTCGAGGAGGGCAGACGGCGGCGGGGGCGCCATGAGTCAGAGGCAGGTGCTGCAAGTGTTCGAGCAATA
CCAGAAGGCCAGGACCCAGTTCGTGCAGATGGTGGCGGAGCTGGCGACTAGACCCCAAAACATCGAGACGCTGCAGAACGCGGAGTCTTG
CTCTGTTGCCAGGCTAGAGTGCAGTGGCATGATCTCGGCTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTC
CTGAGTAGCTGAGACTACAGATGGAGTCTCATTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCCTTGCCCACTGCAGCCTCCA
CCTCCCCGGATCAAGTGATTCTCCTGCCTCAGTCTCCCAAAGTGCTGGGATTAAAGAGGCCTTGTTTATCAGATATTGTGGCAACTATTC
AGACTGCTTTAATTTGTGAACTCTAAATTTCCATGCATTCACTCACCATGGATCTCTGGATACCTAATGGACAGGCAGGTGTAATGTCTT
TGCTGAGAACTCTTCTTCTGGACGTGGTCCCAACAATTCAACAGACTGCTGCTTTGGCTCTTGGGAGACTGGCCAATTATAATGATGACC
TAGCAGAAGCTGTTGTGAAGTGCGACATTCTTCCACAGCTTGTTTATTCATTGGCAGAACAGAATCGCTTCTACAAGAAAGCAGCTGCCT
TTGTGTTACGAGCAGTTGGTAAACATTCTCCCCAGCTAGCTCAGGCAATAGTCGATTGTGGAGCACTGGATACGCTGGTCATATGCTTGG
AAGATTTTGACCCTGGAGTCAAGGAGGCTGCAGCCTGGGCACTTAGATATATTGCAAGACATAATGCAGAGACGCCCAAGCAGATGGCCT
GCGATGAAGTTTAGAAGAGGCTCTGGACATCCTGCCTATGCTGAAGTTGAACCAGTTGGAGAGAAAGAAGGCTTTATTGTATCAGAGCAG
TGCTAAAATTTCTAGGACAGAACAACACCAGTACTGGTTTACAGGTGTTAAGACTAAAATTTTGCCTATACCTTTAAGACAAACAAACAA
ACACACACACAAACAAGCTCTAAGCTGCTGTAGCCTGAAGAAGACAAGATTTCTGGACAAGCTCAGCCCAGGAAACAAAGGGTAAACAAA
AAACTAAAACTTATACAAGATACCATTTACACTGAACATAGAATTCCCTAGTGGAATGTCATCTATAGTTCACTCGGAACATCTCCCGTG
GACTTATCTGAAGTATGACAAGATTATAATGCTTTTGGCTTAGGTGCAGGGTTGCAAAGGGATCAGAAAAAAAAAATCATAATAAAGCTT
TAGTTCATGAGGGATCGACACCTTTGGTTCAAATGTTCTCTGATGTCTCAAAGATAACTGTTTTCCAAAGCCTGAACCCTTTCACTCAAA
AGAGCAATGATGAATGTCTCAAGATTGCTAAGAAAAACAGCCCATGCAAGAGTGAGAACAAACACAAAATAAGAGATTTTCTACATTTTC
AAAACAGATGTGTGGCAAAAGGATGTTGTTTTTCTGGTCTAGATCCATCTGTACCAACAAGTTCATCACTTTACAGAACGAATCTTTTTA
TCCGTACAGGAGGTTCAAACCATGTCTGCCTCTTCCTTTGTAATGAATGACCTTTCTATGAGCTGTGACAAAATTTCCGAACAATTAACT
AAGGATTTGGGAAGAGGGGGTGGCAAACGGGGCTTTCTGTTTTCCTGCCTCAGCATGAAAACATCTGATTTATGCTTTATGGAAGCCTTA
CCTCCAATCCCCAACTGTTAAGTCCCATGAAACCACAGTTGCTCTGGGCTGATGGAAACAAAAGGAAACAGTATGAAGAGTTCCTTAATC
ATTTTTGAAACAAAAATGTTAAGGGATTTTAAACATATGATTATTTTTAATTTTATGCCTTTTCAGTACTAAACACCCATTTCATTGCTG
ATTCCTGTCTAAGAAGCCATTCACGTCAGCATGGCGATAGAAAGAATGAAAAAACCCTGCTGAATCATACAGTAATTTTCTTTAAAGCAC
ATAGTAGTTACATAAATATATATATATAAATATATTTTTGTTTATAACTAACACAAGGCAGGATCTTGTGACTCTAAGAGTGCGTTTTGT
CATCAAGGCAAAACAGATGCAAGATGCATCACTGCATTACTTCCATAGAGTTGTAAAATAATCCTTAATATTAGAATATTTTTCTGTCAC
TTAGCAAAAGTGGTTCAGTTCATTGCCGCGCCCATCATGTTCTTGACTATTTGATCCACTTTTTCGTTTATGTCAACCCCTTCCCTCTCT
GGCTAAATAAAGTGGATGCAGAAAGCTCCTTAAATGGAGATATCGATTGCCTTGGAATCACAATCCTGATTTTGAAAATTCCTCATGAAT
GAAGAAAGGAATGGCATCCCTTGAGAAGGAAAGTGGTTAATATACATACTGAGCTCCTAAAGTTTAAATTCAGGTACTGAGTGTACAATT
TCACCAACATTCTAACCCATGAAACTTTTACACTCTGTGCCAAGAAACTGTTGGCTTTTGTAAGGTACAGTGCTCAACATTTGCAGATTC
AGGTCTCAAGAAGCAGAGATGTCTCATAAGCAGCATTTTCCCAACAGTTTAGCATCTGTACACATCTGCCTTGGTCATCAGTCCACTCAC
AGAGTACCATACTTTATCATCACAAGTGTCTGACGTGAACGAATGCCATTTTCTATTCCATATATTTTGCTTTACAATTTTAAGTATTTG
ATGAAGATGGTAACTTTTTCCTAACTTAGTTAACTATTAAAAAAAATTTTGAAAAGCAAGGTGATTGAAGGATTGTGATGACAATCTCTT
TGCAGCAGCTATGTATGGTTTATGTGAAGTATCCCCACTTATTCTTGTGGAGCAGGTTTGGTGAGACAGCAATAACCAAATGACATGCCA
ATATTACTGGTGCAACTGGTATTCTACAAATGCATAAGGAACACATAGACGACTTCCTTTTAGGATAAAATGATGCTTCTTTCACTACCT
TTTGTGGTAGCTGTGGCTTCCAATAGCAACTGTTTGACAGTTATATAAATCTTGCATGTGTATTCTTAGTTTGTGTCCCTTAAGTACTAC
TTAATTCTCAAGTAGTAATGTTATTCTTATACCCTTCAGCGTTCTATTTTGATTCAAAACAATTGATTCAAAACAATTTTGAATCAATTT
TCTATTTTGATTCAAAACAATTGATAATTCTGTAAAAAAACATAAACACTGAATTCTTCAGTGAACCAAAGCAACAAATAATAGAGAAAA
CTTCTTGAAACTGGAGTGTGGGAAAACTTCTTAACAGAACTAAGAGTTAAAGGTAGTGAGAAGTGTGTGGTGTGTGAATTCTTTAGTGGT
AAGGGGAAATGTGGGCTAAATCCTTTTCTTTCATGAAACTCTCATTCTATTTTATATTTCTGGTTTGTTCTTGTTCCCATGTGAGAAAAC
ATACAGTTTCTGAAAATTCAAAATGGTCATCAATGCTTTGGACTTTACATAATTATGTATTAGAGAAGGTGCAACTGTACATTACTTAAT
ATACTATGAACATAATAGAATAACAAAAAAAGATAACAAAGAGATGCAAACTTCTGGATAAATCAGATAAATGGTGCTACAGAGGAATTT
AGTTATTTCAGCTTAATTATTTGTAAAAATAATAATCAGTGACTAGGTAAAGATACTGAAACTCAAGAAAAATATCTTGACCCATTTATG
TCTAGTGTTCCATTATTGGAACGCTAAGCTTATGGGAGTTATTTAGAGCCTACTGCTCAAGGTCATCACCAAGGTCTGGTTGCAAAAATT
CAAAAAATTGCAACCTCAGGCATAAATGGCTTAAGCCCAAGAGATGGCACTGACCATAAATGGTGGCTTGTGTGTGAAGGGTTTGGACTT
CAAGATATACTAACACCTAGAAAACTAAAAGTGCAATTGACCCCCAATTACTATTTTAGTTTGAGGTATCAAGGGCATTTGCCAATCTCT
TATATGTAGCTTCTAGAGTTGTGCTGTCCAATATTATATCCACTAGCCAACGTGGCTTTTGAAATTAAAATTAATTAAAATTAAATTAAA
AATGTAATTCTTCAGTCACACCAGCCACATTTCAAAGGCTCAATAGCCACGCCTGGCTTGTGGCTACCATATTGGATAACAAGAAACACT
TCCGTGGTTGAAGAAAATTTTAATGGACAATGCTGTGTTTCATTTGAATTCGTTGTCCTTGAAGAAAAGGGAAGAAGAGGAAAGAAACAA
GATTTGGTAGCTCTTGGGCATATCCAAGCATTTTTGATTTTAGAGAGGCCCTATGGAGTAATGAAAAAAATACAAGCTGACACAGCTTTA
AATCCCCACTGTGTTATCTTGGGAAAATCACTTCAACCTCCTTGAGTCTCAATTTGCAATTTTGGAAAAGAAAAACAATTTTTGTCCTGT
CTTTCTTGCAAGATTATTATGCAACCTGATTAAATGTACAGATGTGCAGACTCTTAAAAACCTTATGTTAATGTAACCCATATAAAGTAC
GACTTTTGGTCGAGTACCAGCACAAATTTGCATTCAAAGGAAGAATAGTTCATCAGTGCAAAAAGCGTTCAAAGGTAATCAGTTCATCAC
GTATCTTGAGAAAAAGAGAATGCATTCAAAACACAAAGCAAAATTGCTTCAGTTTCTTTTCTGCCCATCTGAATATTTCCTTTAGTATTT
GTCCCACATGACATCCATCCCATGTATTTATCCACTCTTTCACAACATTGCCTATGAACATCCTTCAACTGGCTCAGTTCTTTATTGCAT
AGAGCCACTTAGCTTCTCTAGTTTCTTATGATTTCCTATTTTACACTTAACAGCAAAAGGAGGCTTCCATTTAGAAGGCACTATCTCAAA
CATAAATAATTTCATATTTATTTTATCACTGTAACACTAAGGAGCTATGGCATTAAAATATAAAACTATTTGGAACTTAATGTAAACCTT
TGCACATGCAGACTATATAAAGGGAATAAAATTATTTTAAATTATGCTAATATCCAGATACATATTCTAAGGTTAGTATCATTTATCAGT
TTTTCGCAACAGATTCTTATGTTACATCTTCATGAGGGAGTATAAATTTGATCACGTCCCTAGTGTCTATTGCCCACTTGAGAAAGGTTT
TGCCAGGATCCACAGATCGCTTCAAGATGCTTTCGTTTATGATAGGAAATTAATATTTAAATAAGACTAATTGAAAACTAGATTATCTGG
TTCTAATTTCTTCCTCCTGTGAAATGTTCTTTTGGTTTGTATTTCTTTAGGTATTTTCCAAGTTACTGCTGCTTTTACTTCACGACCTCC
AACCCCACTTTTGTTATCAGCGTCATATGCCAGAGTCATGGCAGATCCAGCCTGGACAACATAGTGAGACCCATCTCTATCAAATATACA
TATATATATATATATATACACACACACACACACACACACAAATATACATATATATCAAATATATATGTATATTTGATAGAGATGATAGCA
ATTATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTAGCCAAGTGTGGTTTCTCATGCCTGTAGTCCCAGCTACTTTGGAGGCTGAAG
TGTAAGAGTTGCTTGAGCCCATGAGTTAGAGGCTGCTGTGAGCTATGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAAACCCC
ATCTCTAAATAAAAAAAAAGAATCGTGAGACATCATGTAATCCAACCTCTTAATGTTACAGATAAGTAAACTGAGGCCCAAAGAGATATA
GTAATAGTCCCAGTGTCAGTAAACTGGGTCTTGAACTTAAATGTTTGTTTCAGTTCTCATTGCCTTCATCTCTTAATTGTCGGCACTTAA
GGCCAACCAAGCAGCTTAGACAGCGCAGTCCACTCAACGGTAACTTTATTTGCTATATTGACAATCTGCTCTGTTCTGTAATATAGAACA
TTGGATCAATCTTTATCTTTTTGCTGACTTAAGGAGGCTGCTATTGTTGCAATATCCAGAGATTTCAAGTTCTAGCCATTGCGGGGTCTT
TGTGGTGTTTTCAATTTCTCCTCTCTCCACCCCTGCCCCCATCTGTGGCCATCTAAGTTAGCAATACAATTTATTTTGGCCATTTAAAAT
TTTTCTGCCTTTGTTTTATTTCTTCCCAAATATATTTGAAAATGAATGATCTATATAGCTGATTTTCTGACCACATATATAATTGCAATT
TTTATTTGCTCTTCAAACTATTACAACATTTTTGTCCTTATAAGGTTTTTTGGGCAGATAATGCGAGGTCTGTGGTGTTACCTTTTATAT
ACTCCTATTACCTTATGTTTGTGAAGCATTTTACATTTTACAGAGCACTTTGATTCATCTCCCTATTTGTTCATTTATTTAACTGTTCAG
TTCACTGAAATATTTATTGAACACCTACTGGAACCAAGTGACTGTGCTAGTAACTTGTGATATACAGTAGTGAGAGTCCAGGCATGTAAC
CGATCATTATAATACAATAACATCCCTAAACCAGACTTTACAAGTAGATAGGATCAACAATACTCTATCAATTTTCAACTCCAATTTTCT
ATTCTACTTAAAATGGGAACTAGAAACTGTTTGCCTGAAGAATGTGTCTGAAACATAATATATCACTGCATGTCTGTGCTGTAGACCTGT
TAATTTTATCTGTGAGAAAAAAAGTTACTCAAAATTCTCCCTGACCTAAGAATACTTTCTAGTTCACTGCAGTCTTACTGACCAGATGCA
ACAGTTGAAGTTTGATTTCTCGACCCAATATTTCTATTGGGTTTTGAATTATTAATATCACTGTTTTGAGGTATTCAGAAACACCAGTGT
ATCAAAAAAGCATTTGCACTTTAGGTGTGTGTGGTGGTTATGTCATTTATTAGACCATCCCAGACATAAGACAATCAGGGAAATCAGAAA
ACTCCAGCCTCAAATGTGTCTATAATTTCCTGTTCTACCATTGTCATATCATAACATGGTATTACTTCTTAAGGTTTTGATTAAGTTGAT
CTAGCCTCAACTTAAATTGTAATACATCTGCCTAATTATTGTCTGGAATAACTTTTCAACCATCCAATGCCCACTGCTCTCACAATGATT
ATTGTAGAGAAGTAAAATGGTAATTATTCAAGTAAAGTCACATAATTTCTGGAGTCAGTTTTTCATAACAAGTTTATGGAATACATCATC
ATTGGCTTCTTCATAATATATTTATTATGAGTGACCAAATTTTGCCTGGAGGAGCAAAATGCTCAAAACTTGTTATTATAGGTTAATTTC
CAGCTCACTGTTGACACTGAAAGATTCTGTGTTACTTTAAACCCAGGATAAAAGGCTGGAAAAAAAATTAAATGTAAGTCATAAACTAGT
ACTCAGCTTTTCCTAGTTTCTAAGGCTTATTAACATTTGCAAATTACTCAATAAATGTCTTTCATAATGGAATAACATAAAAGCTTTTGA
TTTGGCAGATAGTGATATTTTATTTATTTTCATTCTGGTTGAAAAAAATCTCAGTGGCTTCTCTTCATTCCACGAGAATTTTGATTTTTA
ACAGCAGTCTCTCTTTTTCTCAGCATTGCAAATATATATGTATATATACATTCATGACCAAAGTATCGCTTACTGACCATGCAGCTGTAA
ACCTTCTGTGCCTATCAAACAAATACATAGCATGAAACTAATTTTAGAAGTTTCATGGGGGAATTTTAGGGGAAAGTATAAACCTAAGAG
TGAGTGAATGGAGATGATTCATGGAAAAAAAAATAAAAATCTAAATGTGCTATTAGGCAGAGTTATTAACTTCTTTTAGTTGTTGTTTGA
GATGGGGTTTTGCTCTTGTTACCCAGGCTGGAGTGCAATGGCGTGATCTCGTCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCT
CCTGCCTCAGCCGCCCAAGTAGCTGGGATTACAGGCATATGCCACTACAGCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCC
ATGCTGGTCAGGCTGGTCCCCAGCTCCCGACCTCAGGTGATCCGCCCACCTCCGCCTCCCAAAGTGCTGGAATTACAGGCCTGAGCCACC
GTGCCTGGCCGAGTTATTAACTTCTTAAGAGCAATGTGCTAATAAATACTCATTGATGACCAGCTCAAATTTAGGTCATTCAGACATCCA
GACACTGGGGCACATATTCTGCAAGCAATGCTGAGACCCCTGACATAGAGAAAGCAAAGGATATGCCTATGATTAGTCTAAAATGCAGCC
ATCACCCCCCATACCTCTTCTATGGCATTCATCCTAACATCATGGAGGCCTTTGTCCTAGAGAATTATGTGACTTGCCCTAGAGAATTAG
TGAATGACCAAAAAGAGACTTTCCATTTATCTTCCTTTGACTTAAAAGGCATGAAAATAAGGCAAAAAAATCAATAAAATAATTTTCCTG
AGGAAAGGTTAAGAGATGGCACTTTCCTTTCCGGGCCCAGAGCTGGATTTCTCTGAGATTTGACCATCTCAGGACTCAGACAGACTCCAG
TGCTATTTTCTGGACATTTGTGGTGAAGCCTCAGCCACCATGTTCAAGGTGGTTTGAATGAAAACATACTCAGATTGTCACATTTATAGC
AGGGAAATAAAAACTCAAATTAGGCATCCTGCAGCAGGCTACTCTGAAAATAACATTAGGCAACATCAGAGCTTCACTTGCAAAGAAATG
TTAAAATCATTTTAGGGAAATCAGTGAAGTCTCTTTAGAAACAGACATCTTGTGTATGGCGTAACCCAGTCTTGGGGCCCTCACGGAGAA
GAGGGGGAAGTCTTTTCATTGATTGGTCAAAACAAATCTCTCATTTGCCTGATTTGAAGCATTTCAACAGTGCCTGGAGAGTACATTATT
TTCAGGGGAAAAAAAGGAGAGAGTCTTTTTTATATGCCAGCTGGGATCATGGGAACTTCGAATGCCAGGAATTTACTACTGTTTCTGGTA
ATTCTGTGTGTAGTCATTTGAAATGTTGAAGTGTGAAAAGAGAAGAAATTGGGCACTTCTTGCGGCGGGGGAGGGGGGGGGGGCGGTGGC
TTTCCAGATTTTATGCCAGTTGCACCAGCATGCAGAATATTTGTAATGCATTTCAAAGTGGATATAATGGCACCCTTTGTCAGAATCACA
AAGCTCACTGCGGCACTGCTACAAGAGGACACTGAGGAAAATCTGGCCCTATGAACCTAGTCAACCCCAAGCAAAAAGAATGACTATGTG
TGTGAGTGCAGCACATGGCCAGTTCGTTTCTCACTGTTTTGGAAAGCCCTGTGTGCCAAACCAAGGACGTGTCTTTCAGGGAAAGGTTAA
TTTTCCGAAGTTTATTAAAATAGAACTTGGAAAACCAAGCATTTTGAATTTATTCCAGTCCTCTGGGCATCATTCCTATTTCTTCTGCCA
TGTCAAGGAGAAATTCCAAGCCTGCATTCTGTCATGCTAAAATAACCAGCCCATACTTCTCGGTGACCTTCTGTTGAACGTACCTGAGCC
TGCAAATGTAAAAATGATTGTATCTGAATCTGCACTAATGGTGTCTGAGAGCAAAAAGAGTGTGACCTCTATTGGAAACCTTTGTTCAAA
TTCAATAATTCAGAGATGCTACATACTTCTGCAAGCTTCCTGATTATGTTCACTGTAATATTAATGACCTAAGTTTGAATGTATTTCCTT
ACAGTCCATTAATTTGACATCCATCTTTTACCTGGGGATTATTACAATTGCAATAAGTCATTAATGTTTTCTTCACACAGCTTCTTAAAC
CAAGTTTCTCTGCAGCTCTTTCGGTTCTGCTTACAGTGTGTGGGAAATCTGATTTTTTTCCCCTAGTAATAGTTTGATAAGAAATTTAGT
GTATTGACTGCCTCAGTGACACAATTTATCTTTAAAGGTGTGGAAGCTGGTGGGGACCAAATGTTACCTGTGTTTTTGCTGTTGATTGCT
ATTTTCAGAAGCAAACCATGTTTTTCACTTACAGTAGGAGTCAACAAATTTGGGATTTTAGAAGGGGGAGGAGGGAGCTATTTGTGTAAG
ACTGCTGTCATATTTGACTACATATTAAAAACAGTAAATGAGCATTTTGTTTTAATTTCTTAAATACCTTGTCTTTCAACATACGTTTTG
TTTCCTTTCTTCCATTAGTGTTCAAAAGGTTCTACCCATTGTGGAAGAAATTCTGTGTGCAGAATTCAGAGGCACAAGGCTGATGGCAAG
ATAGAAAGTTATTTTGCTTCTAAACCCACCCCGATGTGGAAACTGATACTAGCTAGAGGGAGCTGTAGAAAACAAAGATTTCAGGATTGC
ACAGTGTGTGGGCAATGGGATGGAGACTTTTTCCCCTATTCCCAGCCACAGTGCCCAAGCGTTCAAGTCTCCTGGATCAGACAGATGGGA
TTTTAGCTGCTGCTTTAAATCCTAGTGCTGGAATAAGTCAAGGTACTTCAGTTCAGCTCTTGCCTCTGTCACTAATCTTGCTTTATGAAC
TCCTTTGATTTTCTGAATAAGTTCCAGAAGGTTCTCTATTATTCTGTCCTTCTTCCAAACTGGAAATGGCTGTATCTAATTCTCAGGATA
TTTTGGATGTGTGCCTCAGGTAATTTATGTGGAATGTGTAAAGCAAGATGTCTCCAATTCTGAATATTCCTTCCCCTTTTCCCAATCCTC
CACTCTTGGACTACCTTTATAACAACACCGAGTACGCACAGACCTGAACCCATGCCCAAGAAGCACACACAATGACTGGAGCTGTCGGGA
ATTCCTGTCAGTGGCATTCCCTGAGCACTGGCTCTGTACAACTCAATTATAATTTTTTAAGAATCATACCTCTGTATAGATCTTTTGGAC

>85445_85445_4_SPAG6-PLXDC2_SPAG6_chr10_22657607_ENST00000538630_PLXDC2_chr10_20568632_ENST00000377252_length(amino acids)=143AA_BP=
MHSLTMDLWIPNGQAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSP

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Fusion Gene PPI Analysis for SPAG6-PLXDC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPAG6-PLXDC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPAG6-PLXDC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource