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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPAG9-CLYBL (FusionGDB2 ID:85455)

Fusion Gene Summary for SPAG9-CLYBL

check button Fusion gene summary
Fusion gene informationFusion gene name: SPAG9-CLYBL
Fusion gene ID: 85455
HgeneTgene
Gene symbol

SPAG9

CLYBL

Gene ID

9043

171425

Gene namesperm associated antigen 9citramalyl-CoA lyase
SynonymsCT89|HLC-6|HLC4|HLC6|JIP-4|JIP4|JLP|PHET|PIG6CLB
Cytomap

17q21.33

13q32.3

Type of geneprotein-codingprotein-coding
DescriptionC-Jun-amino-terminal kinase-interacting protein 4JNK interacting proteinJNK/SAPK-associated proteinMax-binding proteinc-Jun NH2-terminal kinase-associated leucine zipper proteincancer/testis antigen 89human lung cancer oncogene 6 proteinlung cancercitramalyl-CoA lyase, mitochondrial(3S)-malyl-CoA thioesterasebeta-methylmalate synthasecitrate lyase beta likecitrate lyase subunit beta-like protein, mitochondrialmalate synthase
Modification date2020031520200313
UniProtAcc.

Q8N0X4

Ensembl transtripts involved in fusion geneENST00000262013, ENST00000357122, 
ENST00000505279, ENST00000509724, 
ENST00000510283, 		ENST00000339105, 
ENST00000376354, ENST00000376360, 
ENST00000444838, ENST00000376355, 
Fusion gene scores* DoF score20 X 21 X 10=42008 X 7 X 7=392
# samples 2513
** MAII scorelog2(25/4200*10)=-4.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/392*10)=-1.59234203108675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPAG9 [Title/Abstract] AND CLYBL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPAG9(49197715)-CLYBL(100518494), # samples:1
SPAG9(49197715)-CLYBL(100543572), # samples:1
Anticipated loss of major functional domain due to fusion event.SPAG9-CLYBL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPAG9

GO:0042147

retrograde transport, endosome to Golgi

19056739

TgeneCLYBL

GO:0070207

protein homotrimerization

29056341

TgeneCLYBL

GO:0106064

regulation of cobalamin metabolic process

29056341


check buttonFusion gene breakpoints across SPAG9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLYBL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-5275-01ASPAG9chr17

49197715

-CLYBLchr13

100518494

+
ChimerDB4LGGTCGA-DB-5275-01ASPAG9chr17

49197715

-CLYBLchr13

100543572

+


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Fusion Gene ORF analysis for SPAG9-CLYBL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262013ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000262013ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000262013ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000262013ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000357122ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000357122ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000357122ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000357122ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000505279ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000505279ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000505279ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100543572

+
5CDS-intronENST00000505279ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100543572

+
Frame-shiftENST00000262013ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000262013ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000262013ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000262013ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000262013ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000357122ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000357122ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000357122ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000357122ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000357122ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000505279ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000505279ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000505279ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000505279ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100518494

+
Frame-shiftENST00000505279ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100518494

+
In-frameENST00000262013ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100543572

+
In-frameENST00000357122ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100543572

+
In-frameENST00000505279ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-3CDSENST00000509724ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000509724ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000509724ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000509724ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-3CDSENST00000509724ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000509724ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000510283ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000510283ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000510283ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000510283ENST00000376355SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-3CDSENST00000510283ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-3CDSENST00000510283ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100518494

+
intron-intronENST00000509724ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-intronENST00000509724ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-intronENST00000509724ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-intronENST00000509724ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-intronENST00000510283ENST00000339105SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-intronENST00000510283ENST00000376354SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-intronENST00000510283ENST00000376360SPAG9chr17

49197715

-CLYBLchr13

100543572

+
intron-intronENST00000510283ENST00000444838SPAG9chr17

49197715

-CLYBLchr13

100543572

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262013SPAG9chr1749197715-ENST00000376355CLYBLchr13100543572+532351243864889167
ENST00000505279SPAG9chr1749197715-ENST00000376355CLYBLchr13100543572+519238142554758167
ENST00000357122SPAG9chr1749197715-ENST00000376355CLYBLchr13100543572+532351243864889167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262013ENST00000376355SPAG9chr1749197715-CLYBLchr13100543572+0.570641640.4293583
ENST00000505279ENST00000376355SPAG9chr1749197715-CLYBLchr13100543572+0.5533170.44668296
ENST00000357122ENST00000376355SPAG9chr1749197715-CLYBLchr13100543572+0.570641640.4293583

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Fusion Genomic Features for SPAG9-CLYBL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPAG9chr1749197714-CLYBLchr13100518493+2.94E-121
SPAG9chr1749197714-CLYBLchr13100543571+4.78E-171
SPAG9chr1749197714-CLYBLchr13100518493+2.94E-121
SPAG9chr1749197714-CLYBLchr13100543571+4.78E-171

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPAG9-CLYBL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:49197715/chr13:100518494)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLYBL

Q8N0X4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). {ECO:0000269|PubMed:24334609, ECO:0000269|PubMed:29056341}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG9chr17:49197715chr13:100543572ENST00000262013-1307_951011322.0DomainRH1
HgeneSPAG9chr17:49197715chr13:100543572ENST00000357122-1297_951011308.0DomainRH1
HgeneSPAG9chr17:49197715chr13:100543572ENST00000505279-1307_951011312.0DomainRH1
TgeneCLYBLchr17:49197715chr13:100543572ENST0000037635457272_273275307.0RegionSubstrate binding
TgeneCLYBLchr17:49197715chr13:100543572ENST0000037635558272_2732751839.6666666666667RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG9chr17:49197715chr13:100543572ENST00000262013-130408_5341011322.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49197715chr13:100543572ENST00000262013-13066_1661011322.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000262013-130724_7581011322.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000357122-129408_5341011308.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49197715chr13:100543572ENST00000357122-12966_1661011308.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000357122-129724_7581011308.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000505279-130408_5341011312.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49197715chr13:100543572ENST00000505279-13066_1661011312.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000505279-130724_7581011312.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000510283-127408_53401178.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49197715chr13:100543572ENST00000510283-12766_16601178.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000510283-127724_75801178.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49197715chr13:100543572ENST00000262013-130500_5711011322.0DomainRH2
HgeneSPAG9chr17:49197715chr13:100543572ENST00000357122-129500_5711011308.0DomainRH2
HgeneSPAG9chr17:49197715chr13:100543572ENST00000505279-130500_5711011312.0DomainRH2
HgeneSPAG9chr17:49197715chr13:100543572ENST00000510283-127500_57101178.0DomainRH2
HgeneSPAG9chr17:49197715chr13:100543572ENST00000510283-1277_9501178.0DomainRH1
TgeneCLYBLchr17:49197715chr13:100543572ENST0000033910569272_273309361.0RegionSubstrate binding
TgeneCLYBLchr17:49197715chr13:100543572ENST0000037636068272_273309341.0RegionSubstrate binding


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Fusion Gene Sequence for SPAG9-CLYBL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85455_85455_1_SPAG9-CLYBL_SPAG9_chr17_49197715_ENST00000262013_CLYBL_chr13_100543572_ENST00000376355_length(transcript)=5323nt_BP=512nt
AGTTGGTGCAGCGGCGGTTGGGGTGAGAGCGCCTACGCCACCCCTCCCCTCCTCCGGCCCCGGCCCCCACCCCGCCGGGCCCAGCCCCAG
CCCCGGCCCGGGCTCCAGCCCTAGTACCCGTCCCAGCCCGAGTCGGGTCCGTCCCGTGCGGGCAGGTGCCGCCCCTCTGCCGGCGACGCC
CCGGGCCGCCCGCCCGTCCGCTTGCCACCATGGAGCTGGAGGACGGTGTGGTGTATCAGGAGGAGCCCGGCGGCTCCGGGGCCGTGATGT
CGGAGCGGGTGTCCGGCCTGGCCGGCTCCATCTACCGCGAGTTCGAGCGGCTTATCGGGCGCTATGACGAGGAGGTGGTCAAAGAGCTGA
TGCCGCTGGTGGTGGCTGTGCTGGAGAACCTGGACTCGGTGTTCGCGCAGGACCAGGAGCACCAGGTGGAGCTGGAGCTGCTGCGGGACG
ACAACGAGCAGCTCATCACCCAGTACGAGCGGGAGAAGGCGCTGCGCAAGCACGCTGAGGAGGGGGCCTTTACTTTCCAAGGGAGTATGA
TCGACATGCCATTACTGAAGCAGGCCCAGAACACTGTTACGCTTGCCACCTCCATCAAGGAAAAATGATCTGTTAAATGAAGCTGTCATC
AGGCTAAAGGGTATTGAAGCTGCAGAGGGATCAACTTGTGCTTGCCAGAGGACGCCAATGAAGTTTGAAACACCAACAATCAGAGATTTT
GTTTCTGTTCCTCATTAAATCATGAGCTTTTGTGCCGAGACTCTGGACGACTGTTCCTTAAGAAATTAACAGAATGGGAAGTTTTAAACT
CTACACCAACCTTTTCATGACCTACACAGCAGCAACGCTGCTACTCTTAGACAAACACCGCGGGGAAGGCTGTTCTGTTTATTTAAATTT
GTAAATAGAAAACAGTTGTTTTTTACTTTCATTTTTCACCTCCTCCTACGCCCTTTTGGATTATTTCCTCTGCGGCCCCTAGCATGAGCC
CCAACCAGGCCTCCCCTTTTCCCCACTTCTCTCAATTCCCACAGGAAGCCCGAGAGGTGAGGAGCTGAGGTTAGACACCAGGAGAGGCAC
CATCACACAAAAGCGCGGCCGCAGAGTCCCACCGCCACCAGGCGACCCCCACCCAGAGAGGGACAGACATGCGGGGAGCCAGCACCGGGC
AAGATGGCTCTGGGGATCCTCATTCTGTGAAGACACCAACTCATTTCTCAAACACAGGATCCAGGAGACAGATAGCTCCTAAATGGAGAT
GGCACATGCTCCGTGGGGTCCCTCATAGAGGAGTGCCACCCTCCACACTGGCCACGCTGGGCTGCCCCAGAGCGGCCAGAAAGGAAGGTG
GGAGCTAGCCCCATCCTCACTCAGAGGCCGGAAGGAGGAAGATGGCATCTCGCCAACTTCAGAGCCGAATGGCCTCTAGCCACACTGCTT
CCAGACCCCAGACGGGGCAGCAGCAGCAGTTCCCAGAGGAGCACCCATTGTTGCAGCTAGGACCCACCAAGGATGGGACTCCTGGAGTCA
GGTGCACACCAGGTAACCCAGGACCACGCTGTGCACCCCCAGTCTGCCCCTCTGCTCAGAACACAGAGGGATGGGAGGATGGCTTGGCAG
TGGGAAGGCAAAAGAAGGCCTCTCTCACTCTGCCCCTGCCATACGCACCCGCTGAGGGTGTTAGAAGCAGTGGAGGCAGAGCTGGCCCTA
AGCAAAAGAAGAAAATAAACCTCACCTTGTCCTTCCTATGGGCAGCCCTCACCCCAATCTAACTAACCTTCCCATCCTCCAGCCTAATCC
AAAGAAGCCCTTGGCTTGAGGGGATGAAGGGCTTGCGTTCTAGTCTCCACCCCAGCCCCACAGGCAGCCAGCCAGCCAGCCCCACACAGA
GGGGCCTCCTCAAGGCCTCACTGGGAGCCTCCTGTCCCCAGCCAAGGAGCCCTACAGACCTGGGGAAAAGCAGGCCCCTCCGCAAGGCCC
CTGGGTGGTGCGGAGGCCGGACCGGCTAGGCCTCCCGCTGCTGGCCACTCCCAGGCCACGGGTTCCTAGGTCCCAACCACATTGGACTGC
TCGCCACGCCACTGCCCTCATCCCAAACTGCTTTGTTCAAACAAAACCACCTTGTTTCAGTCTCCCCAAATGTCCAGTTCATTATCTTCC
TCATAACCCATGGTCCCTATTAGGGTAGGATCATGAGACTAAGACCTATGAGAGCCACAAATCTGGACCAAAGTCCCATTCCCTGAACAG
AGACCCAAACGACGAGGGTCCCAGAAGAGAGTTCAGTCCTGATCAGAAACCCATGGTGCCTTAGTCCTTGAAGAACAAAACTCTAGGAAG
AAGATGCTGGAAGGCAAAGGGTATTCCCCCTCTTTCCCCACCCGCGTCTCTGTGGTGCCATGGGTGGGCCCAGGTACCCTGGGAAAGGTG
GGAGAGCAGTCAAGGGTGGGTGTGTGATCTCCACTGGGCTCACTGGGCACCCCCGACACGGGGAAGTGAGAGCTGCCCGACTCCTGAGCC
AGGCGTGGGTGACAGGAAGAGGACCTTGCAGCTAATCTGATTCATTAGAAACCATACCTGTTTATGTTTTGTGTAGCTCATCACAAGCCG
CTTAGCCATATCACCCCCGTTATTAATTCTTGGGGTCTAAATTATGGGTAACACTATTAAAACATTATCAGAACTAATGAGAAACAATTA
CTTAGAAAATGAGCCGGGACAAGACTGAGTTGGGAACATCAGTGGTGATCACTGTAGATTAGTTTAATAAATCATCAGGTGCAAGGCAAG
ACTGACTGTATGTATGCAAAGCCCCGTCACGGGAAAATGAAATTGAGATTTTTTTTTTTTGCATAATTTTTTCATTAATCTCAATAGGAC
CCGTGTGGTGTAGATTGCTTTATTCCCCTAATACCTTGCCTGAGGCGGGGGGGGGGGGGGGTGCCCAATAATGTCTTCATTGTTTTACTG
AGGTCTTAATGACAATCTGTGACAACCTCATTTTAATGTATAGAGGATTATATCAATACAGTCATGTTTTATTGAAATGGTGAAGGGAAC
TCCAGTCAGAGTCAGGCAGTGTCTGTGAGCACAAGTTAGGAAGTTTCTCGGCATCCGGGAGCGTTCCCGTCTGATGTCCCAGTGTTAGTC
CTCCCGGCCGCCCTCCCCTCCTCTCCTCCAGGGACGGCTGGGAAAACAGTCCTGCGGGATGAAGACTTCACCGCCTCCGATTTGAATTTG
AAAGTAACTCCTTCCGTGGCATATTTCGCTGGGCAGATAGAACAAACCATGTCGTTTTCCCCCGTCTCTAAAATAGACATATTATTATCA
TTCACACTTTTGCACCCGGTCGTTTTGCGGGAGTTCGGGAAACTGACTTTCTTCATTGGGGACATTGTAATTTTCTGATGATGCCACGAG
GAGAAAAAAAATACGGGTTTGTTTTAATTGGAAGGACCTTCCGCTTTTATGATTTCGGTTTACCTTGGAAAACTGAATCTTCTGTGTTTT
ATTTCTTTCCTCTAGTACTAGAAAAGCAATGAATTAATTGCACAAAACAGGTTCTGAGACGGCCCGCAGGCCCCGAGCTCGTGGACGCGG
CCGAGGGTCGGGTGTGACCCGCGGAGCCGCTGCCAGGCTTCCCAGCTCGTCTTCGCGGGGAGGCGGGAGGCAGGACCAGACCCCAGCATT
TCAGCGTGAAAGTCTTCGCCTTTCTTTCCGCGCTGTCTTTCCCGCGGGCGGAGCGGCGTACCTGAGCGCGGTCCCCACGGAGGATCAGTG
ACTTTCCCAGACCCCGCGGGCGAGCCCGCGCTTGGGACCCGGCAGCTCTGCGCGGGCTGGTTTTGGAGGGGGTGGTGTTCGTTTGTTTAA
ATTCCAGTTGTTATTTGGCAGCATATCGCCTTCCGAGTCAGTAAGAATTGCCCACGACGTAAAGAGCGACTTGCAGGAAGGGGCCGAAGC
CGTCGTTAGCGCCCGGGCGGCGGCGGCCACTCGAACCCCGTTTCCGCCAAGCGCGCTGCAACCTGCGGGGCGAGTTCGTTTTGTTTTGCC
AAAATCATTTGGGGACTTCTTTGTCATTCATGCCCTTCCTTTTAAATGATTTTTATTTTTTTCCACTGTAAGTGACCGGCTGGGTTTGAC
TTTTGCTTCTTCCGACGGAAGGGCACCGCGAGCCGGGGTGGGCGGCCCCGCGGGCAGGAGGAGCGCGGGGTACACGCGGTGGCCGCAGAC
GCCGAGCCCTGCGGAGCCCCGAGGCCTCGTCGCCCGCGCCCCCGGTGCGCGCGGAGCCGGGGCCGAGGCCGGGCCAGGAGGAGTGTGGCG
GCCCAGGAGGCCTGGACTGTGGGCCCTGCTCGCCCGCCCGCCGCGGGCCGCCCGGAGCCCGCGCGCCTGTCGCGCAGCCCGGCTGTAATG
GTGGCAGATCAAAGGCGGCCCCGTGTCCCCGCGGAGCCCGGGACAATCCCGCGCCTTTGTGCGCTGTTGCTAGGAGCCCGAGAAACTAAG
AGAAAGTGTCAGGAGCATGTTAATCAGACTCGTTACACTGTAACAATAACGTCTCTCTCGGGTCTCCCAGGCCCCAGTACCCCCGCGCAC
CCTGCGCGCAGGCCGGACACCTGCGCAGGGCCCTTGCGCCCGCCCTGGGGTCCCGCCGGCCCTGGGGTCCCTGCAGCCCCGAATCCGCAC
CCGAGCCACGCGGAACGACTAGCCCCGAGGGGCCCCGCAGGCTCCCGGTGCAGCTCCCTGGTCGTGGTCTCCTTGACCGAAGCCCCGGCC
TCACACCGCCTGGCCGCGAGCCCGAGGGACGCAGGGACGATCCCGGTCCCCTGCTTTTCAGTCCTCCAGTCGAATCGCCCACTTTGTTCA
ATCACAGTATTCGAATCAAGAGGAAAATGAACATTCCCTTTATGGTAGCTTTTTGGTTATGAGTTTTGGCAAAACTGTTAAATCAACTTT
GCCGATTTCCCTTGGGAATCCCTGGAGGCCACTCTAAGTGGTAATCCCAAGTTTAAGAAGGAAATGGGGAAATTTTGCTGAGAGTAAAGA
TGTCGCCGAACTTTTTGAAGGGATTTGCTTCATTCATTCATTTAGTCATTCAACAGACACCTGTTGAACCCGACTGGGTGCCAGAGGGGC
CAGTCACAGGACTTATTCCAGATGAACTTTTCTTTTGAAATTAGAATGCCCTTGTGGAAGCCAAAGGAGGAGCAGAGGCCTAAAATAATG
TCAAGTGTCAAAGCAAAAAGAAGTGCCATTGGCTACTACAGTGTGTGATGATAACAAGAGAGGTGCGAATTAGGAATTAAAAACGTTTGA

>85455_85455_1_SPAG9-CLYBL_SPAG9_chr17_49197715_ENST00000262013_CLYBL_chr13_100543572_ENST00000376355_length(amino acids)=167AA_BP=
MSRSPAVMVADQRRPRVPAEPGTIPRLCALLLGARETKRKCQEHVNQTRYTVTITSLSGLPGPSTPAHPARRPDTCAGPLRPPWGPAGPG

--------------------------------------------------------------
>85455_85455_2_SPAG9-CLYBL_SPAG9_chr17_49197715_ENST00000357122_CLYBL_chr13_100543572_ENST00000376355_length(transcript)=5323nt_BP=512nt
AGTTGGTGCAGCGGCGGTTGGGGTGAGAGCGCCTACGCCACCCCTCCCCTCCTCCGGCCCCGGCCCCCACCCCGCCGGGCCCAGCCCCAG
CCCCGGCCCGGGCTCCAGCCCTAGTACCCGTCCCAGCCCGAGTCGGGTCCGTCCCGTGCGGGCAGGTGCCGCCCCTCTGCCGGCGACGCC
CCGGGCCGCCCGCCCGTCCGCTTGCCACCATGGAGCTGGAGGACGGTGTGGTGTATCAGGAGGAGCCCGGCGGCTCCGGGGCCGTGATGT
CGGAGCGGGTGTCCGGCCTGGCCGGCTCCATCTACCGCGAGTTCGAGCGGCTTATCGGGCGCTATGACGAGGAGGTGGTCAAAGAGCTGA
TGCCGCTGGTGGTGGCTGTGCTGGAGAACCTGGACTCGGTGTTCGCGCAGGACCAGGAGCACCAGGTGGAGCTGGAGCTGCTGCGGGACG
ACAACGAGCAGCTCATCACCCAGTACGAGCGGGAGAAGGCGCTGCGCAAGCACGCTGAGGAGGGGGCCTTTACTTTCCAAGGGAGTATGA
TCGACATGCCATTACTGAAGCAGGCCCAGAACACTGTTACGCTTGCCACCTCCATCAAGGAAAAATGATCTGTTAAATGAAGCTGTCATC
AGGCTAAAGGGTATTGAAGCTGCAGAGGGATCAACTTGTGCTTGCCAGAGGACGCCAATGAAGTTTGAAACACCAACAATCAGAGATTTT
GTTTCTGTTCCTCATTAAATCATGAGCTTTTGTGCCGAGACTCTGGACGACTGTTCCTTAAGAAATTAACAGAATGGGAAGTTTTAAACT
CTACACCAACCTTTTCATGACCTACACAGCAGCAACGCTGCTACTCTTAGACAAACACCGCGGGGAAGGCTGTTCTGTTTATTTAAATTT
GTAAATAGAAAACAGTTGTTTTTTACTTTCATTTTTCACCTCCTCCTACGCCCTTTTGGATTATTTCCTCTGCGGCCCCTAGCATGAGCC
CCAACCAGGCCTCCCCTTTTCCCCACTTCTCTCAATTCCCACAGGAAGCCCGAGAGGTGAGGAGCTGAGGTTAGACACCAGGAGAGGCAC
CATCACACAAAAGCGCGGCCGCAGAGTCCCACCGCCACCAGGCGACCCCCACCCAGAGAGGGACAGACATGCGGGGAGCCAGCACCGGGC
AAGATGGCTCTGGGGATCCTCATTCTGTGAAGACACCAACTCATTTCTCAAACACAGGATCCAGGAGACAGATAGCTCCTAAATGGAGAT
GGCACATGCTCCGTGGGGTCCCTCATAGAGGAGTGCCACCCTCCACACTGGCCACGCTGGGCTGCCCCAGAGCGGCCAGAAAGGAAGGTG
GGAGCTAGCCCCATCCTCACTCAGAGGCCGGAAGGAGGAAGATGGCATCTCGCCAACTTCAGAGCCGAATGGCCTCTAGCCACACTGCTT
CCAGACCCCAGACGGGGCAGCAGCAGCAGTTCCCAGAGGAGCACCCATTGTTGCAGCTAGGACCCACCAAGGATGGGACTCCTGGAGTCA
GGTGCACACCAGGTAACCCAGGACCACGCTGTGCACCCCCAGTCTGCCCCTCTGCTCAGAACACAGAGGGATGGGAGGATGGCTTGGCAG
TGGGAAGGCAAAAGAAGGCCTCTCTCACTCTGCCCCTGCCATACGCACCCGCTGAGGGTGTTAGAAGCAGTGGAGGCAGAGCTGGCCCTA
AGCAAAAGAAGAAAATAAACCTCACCTTGTCCTTCCTATGGGCAGCCCTCACCCCAATCTAACTAACCTTCCCATCCTCCAGCCTAATCC
AAAGAAGCCCTTGGCTTGAGGGGATGAAGGGCTTGCGTTCTAGTCTCCACCCCAGCCCCACAGGCAGCCAGCCAGCCAGCCCCACACAGA
GGGGCCTCCTCAAGGCCTCACTGGGAGCCTCCTGTCCCCAGCCAAGGAGCCCTACAGACCTGGGGAAAAGCAGGCCCCTCCGCAAGGCCC
CTGGGTGGTGCGGAGGCCGGACCGGCTAGGCCTCCCGCTGCTGGCCACTCCCAGGCCACGGGTTCCTAGGTCCCAACCACATTGGACTGC
TCGCCACGCCACTGCCCTCATCCCAAACTGCTTTGTTCAAACAAAACCACCTTGTTTCAGTCTCCCCAAATGTCCAGTTCATTATCTTCC
TCATAACCCATGGTCCCTATTAGGGTAGGATCATGAGACTAAGACCTATGAGAGCCACAAATCTGGACCAAAGTCCCATTCCCTGAACAG
AGACCCAAACGACGAGGGTCCCAGAAGAGAGTTCAGTCCTGATCAGAAACCCATGGTGCCTTAGTCCTTGAAGAACAAAACTCTAGGAAG
AAGATGCTGGAAGGCAAAGGGTATTCCCCCTCTTTCCCCACCCGCGTCTCTGTGGTGCCATGGGTGGGCCCAGGTACCCTGGGAAAGGTG
GGAGAGCAGTCAAGGGTGGGTGTGTGATCTCCACTGGGCTCACTGGGCACCCCCGACACGGGGAAGTGAGAGCTGCCCGACTCCTGAGCC
AGGCGTGGGTGACAGGAAGAGGACCTTGCAGCTAATCTGATTCATTAGAAACCATACCTGTTTATGTTTTGTGTAGCTCATCACAAGCCG
CTTAGCCATATCACCCCCGTTATTAATTCTTGGGGTCTAAATTATGGGTAACACTATTAAAACATTATCAGAACTAATGAGAAACAATTA
CTTAGAAAATGAGCCGGGACAAGACTGAGTTGGGAACATCAGTGGTGATCACTGTAGATTAGTTTAATAAATCATCAGGTGCAAGGCAAG
ACTGACTGTATGTATGCAAAGCCCCGTCACGGGAAAATGAAATTGAGATTTTTTTTTTTTGCATAATTTTTTCATTAATCTCAATAGGAC
CCGTGTGGTGTAGATTGCTTTATTCCCCTAATACCTTGCCTGAGGCGGGGGGGGGGGGGGGTGCCCAATAATGTCTTCATTGTTTTACTG
AGGTCTTAATGACAATCTGTGACAACCTCATTTTAATGTATAGAGGATTATATCAATACAGTCATGTTTTATTGAAATGGTGAAGGGAAC
TCCAGTCAGAGTCAGGCAGTGTCTGTGAGCACAAGTTAGGAAGTTTCTCGGCATCCGGGAGCGTTCCCGTCTGATGTCCCAGTGTTAGTC
CTCCCGGCCGCCCTCCCCTCCTCTCCTCCAGGGACGGCTGGGAAAACAGTCCTGCGGGATGAAGACTTCACCGCCTCCGATTTGAATTTG
AAAGTAACTCCTTCCGTGGCATATTTCGCTGGGCAGATAGAACAAACCATGTCGTTTTCCCCCGTCTCTAAAATAGACATATTATTATCA
TTCACACTTTTGCACCCGGTCGTTTTGCGGGAGTTCGGGAAACTGACTTTCTTCATTGGGGACATTGTAATTTTCTGATGATGCCACGAG
GAGAAAAAAAATACGGGTTTGTTTTAATTGGAAGGACCTTCCGCTTTTATGATTTCGGTTTACCTTGGAAAACTGAATCTTCTGTGTTTT
ATTTCTTTCCTCTAGTACTAGAAAAGCAATGAATTAATTGCACAAAACAGGTTCTGAGACGGCCCGCAGGCCCCGAGCTCGTGGACGCGG
CCGAGGGTCGGGTGTGACCCGCGGAGCCGCTGCCAGGCTTCCCAGCTCGTCTTCGCGGGGAGGCGGGAGGCAGGACCAGACCCCAGCATT
TCAGCGTGAAAGTCTTCGCCTTTCTTTCCGCGCTGTCTTTCCCGCGGGCGGAGCGGCGTACCTGAGCGCGGTCCCCACGGAGGATCAGTG
ACTTTCCCAGACCCCGCGGGCGAGCCCGCGCTTGGGACCCGGCAGCTCTGCGCGGGCTGGTTTTGGAGGGGGTGGTGTTCGTTTGTTTAA
ATTCCAGTTGTTATTTGGCAGCATATCGCCTTCCGAGTCAGTAAGAATTGCCCACGACGTAAAGAGCGACTTGCAGGAAGGGGCCGAAGC
CGTCGTTAGCGCCCGGGCGGCGGCGGCCACTCGAACCCCGTTTCCGCCAAGCGCGCTGCAACCTGCGGGGCGAGTTCGTTTTGTTTTGCC
AAAATCATTTGGGGACTTCTTTGTCATTCATGCCCTTCCTTTTAAATGATTTTTATTTTTTTCCACTGTAAGTGACCGGCTGGGTTTGAC
TTTTGCTTCTTCCGACGGAAGGGCACCGCGAGCCGGGGTGGGCGGCCCCGCGGGCAGGAGGAGCGCGGGGTACACGCGGTGGCCGCAGAC
GCCGAGCCCTGCGGAGCCCCGAGGCCTCGTCGCCCGCGCCCCCGGTGCGCGCGGAGCCGGGGCCGAGGCCGGGCCAGGAGGAGTGTGGCG
GCCCAGGAGGCCTGGACTGTGGGCCCTGCTCGCCCGCCCGCCGCGGGCCGCCCGGAGCCCGCGCGCCTGTCGCGCAGCCCGGCTGTAATG
GTGGCAGATCAAAGGCGGCCCCGTGTCCCCGCGGAGCCCGGGACAATCCCGCGCCTTTGTGCGCTGTTGCTAGGAGCCCGAGAAACTAAG
AGAAAGTGTCAGGAGCATGTTAATCAGACTCGTTACACTGTAACAATAACGTCTCTCTCGGGTCTCCCAGGCCCCAGTACCCCCGCGCAC
CCTGCGCGCAGGCCGGACACCTGCGCAGGGCCCTTGCGCCCGCCCTGGGGTCCCGCCGGCCCTGGGGTCCCTGCAGCCCCGAATCCGCAC
CCGAGCCACGCGGAACGACTAGCCCCGAGGGGCCCCGCAGGCTCCCGGTGCAGCTCCCTGGTCGTGGTCTCCTTGACCGAAGCCCCGGCC
TCACACCGCCTGGCCGCGAGCCCGAGGGACGCAGGGACGATCCCGGTCCCCTGCTTTTCAGTCCTCCAGTCGAATCGCCCACTTTGTTCA
ATCACAGTATTCGAATCAAGAGGAAAATGAACATTCCCTTTATGGTAGCTTTTTGGTTATGAGTTTTGGCAAAACTGTTAAATCAACTTT
GCCGATTTCCCTTGGGAATCCCTGGAGGCCACTCTAAGTGGTAATCCCAAGTTTAAGAAGGAAATGGGGAAATTTTGCTGAGAGTAAAGA
TGTCGCCGAACTTTTTGAAGGGATTTGCTTCATTCATTCATTTAGTCATTCAACAGACACCTGTTGAACCCGACTGGGTGCCAGAGGGGC
CAGTCACAGGACTTATTCCAGATGAACTTTTCTTTTGAAATTAGAATGCCCTTGTGGAAGCCAAAGGAGGAGCAGAGGCCTAAAATAATG
TCAAGTGTCAAAGCAAAAAGAAGTGCCATTGGCTACTACAGTGTGTGATGATAACAAGAGAGGTGCGAATTAGGAATTAAAAACGTTTGA

>85455_85455_2_SPAG9-CLYBL_SPAG9_chr17_49197715_ENST00000357122_CLYBL_chr13_100543572_ENST00000376355_length(amino acids)=167AA_BP=
MSRSPAVMVADQRRPRVPAEPGTIPRLCALLLGARETKRKCQEHVNQTRYTVTITSLSGLPGPSTPAHPARRPDTCAGPLRPPWGPAGPG

--------------------------------------------------------------
>85455_85455_3_SPAG9-CLYBL_SPAG9_chr17_49197715_ENST00000505279_CLYBL_chr13_100543572_ENST00000376355_length(transcript)=5192nt_BP=381nt
GTCGGGTCCGTCCCGTGCGGGCAGGTGCCGCCCCTCTGCCGGCGACGCCCCGGGCCGCCCGCCCGTCCGCTTGCCACCATGGAGCTGGAG
GACGGTGTGGTGTATCAGGAGGAGCCCGGCGGCTCCGGGGCCGTGATGTCGGAGCGGGTGTCCGGCCTGGCCGGCTCCATCTACCGCGAG
TTCGAGCGGCTTATCGGGCGCTATGACGAGGAGGTGGTCAAAGAGCTGATGCCGCTGGTGGTGGCTGTGCTGGAGAACCTGGACTCGGTG
TTCGCGCAGGACCAGGAGCACCAGGTGGAGCTGGAGCTGCTGCGGGACGACAACGAGCAGCTCATCACCCAGTACGAGCGGGAGAAGGCG
CTGCGCAAGCACGCTGAGGAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACATGCCATTACTGAAGCAGGCCCAGAACACTGTTACG
CTTGCCACCTCCATCAAGGAAAAATGATCTGTTAAATGAAGCTGTCATCAGGCTAAAGGGTATTGAAGCTGCAGAGGGATCAACTTGTGC
TTGCCAGAGGACGCCAATGAAGTTTGAAACACCAACAATCAGAGATTTTGTTTCTGTTCCTCATTAAATCATGAGCTTTTGTGCCGAGAC
TCTGGACGACTGTTCCTTAAGAAATTAACAGAATGGGAAGTTTTAAACTCTACACCAACCTTTTCATGACCTACACAGCAGCAACGCTGC
TACTCTTAGACAAACACCGCGGGGAAGGCTGTTCTGTTTATTTAAATTTGTAAATAGAAAACAGTTGTTTTTTACTTTCATTTTTCACCT
CCTCCTACGCCCTTTTGGATTATTTCCTCTGCGGCCCCTAGCATGAGCCCCAACCAGGCCTCCCCTTTTCCCCACTTCTCTCAATTCCCA
CAGGAAGCCCGAGAGGTGAGGAGCTGAGGTTAGACACCAGGAGAGGCACCATCACACAAAAGCGCGGCCGCAGAGTCCCACCGCCACCAG
GCGACCCCCACCCAGAGAGGGACAGACATGCGGGGAGCCAGCACCGGGCAAGATGGCTCTGGGGATCCTCATTCTGTGAAGACACCAACT
CATTTCTCAAACACAGGATCCAGGAGACAGATAGCTCCTAAATGGAGATGGCACATGCTCCGTGGGGTCCCTCATAGAGGAGTGCCACCC
TCCACACTGGCCACGCTGGGCTGCCCCAGAGCGGCCAGAAAGGAAGGTGGGAGCTAGCCCCATCCTCACTCAGAGGCCGGAAGGAGGAAG
ATGGCATCTCGCCAACTTCAGAGCCGAATGGCCTCTAGCCACACTGCTTCCAGACCCCAGACGGGGCAGCAGCAGCAGTTCCCAGAGGAG
CACCCATTGTTGCAGCTAGGACCCACCAAGGATGGGACTCCTGGAGTCAGGTGCACACCAGGTAACCCAGGACCACGCTGTGCACCCCCA
GTCTGCCCCTCTGCTCAGAACACAGAGGGATGGGAGGATGGCTTGGCAGTGGGAAGGCAAAAGAAGGCCTCTCTCACTCTGCCCCTGCCA
TACGCACCCGCTGAGGGTGTTAGAAGCAGTGGAGGCAGAGCTGGCCCTAAGCAAAAGAAGAAAATAAACCTCACCTTGTCCTTCCTATGG
GCAGCCCTCACCCCAATCTAACTAACCTTCCCATCCTCCAGCCTAATCCAAAGAAGCCCTTGGCTTGAGGGGATGAAGGGCTTGCGTTCT
AGTCTCCACCCCAGCCCCACAGGCAGCCAGCCAGCCAGCCCCACACAGAGGGGCCTCCTCAAGGCCTCACTGGGAGCCTCCTGTCCCCAG
CCAAGGAGCCCTACAGACCTGGGGAAAAGCAGGCCCCTCCGCAAGGCCCCTGGGTGGTGCGGAGGCCGGACCGGCTAGGCCTCCCGCTGC
TGGCCACTCCCAGGCCACGGGTTCCTAGGTCCCAACCACATTGGACTGCTCGCCACGCCACTGCCCTCATCCCAAACTGCTTTGTTCAAA
CAAAACCACCTTGTTTCAGTCTCCCCAAATGTCCAGTTCATTATCTTCCTCATAACCCATGGTCCCTATTAGGGTAGGATCATGAGACTA
AGACCTATGAGAGCCACAAATCTGGACCAAAGTCCCATTCCCTGAACAGAGACCCAAACGACGAGGGTCCCAGAAGAGAGTTCAGTCCTG
ATCAGAAACCCATGGTGCCTTAGTCCTTGAAGAACAAAACTCTAGGAAGAAGATGCTGGAAGGCAAAGGGTATTCCCCCTCTTTCCCCAC
CCGCGTCTCTGTGGTGCCATGGGTGGGCCCAGGTACCCTGGGAAAGGTGGGAGAGCAGTCAAGGGTGGGTGTGTGATCTCCACTGGGCTC
ACTGGGCACCCCCGACACGGGGAAGTGAGAGCTGCCCGACTCCTGAGCCAGGCGTGGGTGACAGGAAGAGGACCTTGCAGCTAATCTGAT
TCATTAGAAACCATACCTGTTTATGTTTTGTGTAGCTCATCACAAGCCGCTTAGCCATATCACCCCCGTTATTAATTCTTGGGGTCTAAA
TTATGGGTAACACTATTAAAACATTATCAGAACTAATGAGAAACAATTACTTAGAAAATGAGCCGGGACAAGACTGAGTTGGGAACATCA
GTGGTGATCACTGTAGATTAGTTTAATAAATCATCAGGTGCAAGGCAAGACTGACTGTATGTATGCAAAGCCCCGTCACGGGAAAATGAA
ATTGAGATTTTTTTTTTTTGCATAATTTTTTCATTAATCTCAATAGGACCCGTGTGGTGTAGATTGCTTTATTCCCCTAATACCTTGCCT
GAGGCGGGGGGGGGGGGGGGTGCCCAATAATGTCTTCATTGTTTTACTGAGGTCTTAATGACAATCTGTGACAACCTCATTTTAATGTAT
AGAGGATTATATCAATACAGTCATGTTTTATTGAAATGGTGAAGGGAACTCCAGTCAGAGTCAGGCAGTGTCTGTGAGCACAAGTTAGGA
AGTTTCTCGGCATCCGGGAGCGTTCCCGTCTGATGTCCCAGTGTTAGTCCTCCCGGCCGCCCTCCCCTCCTCTCCTCCAGGGACGGCTGG
GAAAACAGTCCTGCGGGATGAAGACTTCACCGCCTCCGATTTGAATTTGAAAGTAACTCCTTCCGTGGCATATTTCGCTGGGCAGATAGA
ACAAACCATGTCGTTTTCCCCCGTCTCTAAAATAGACATATTATTATCATTCACACTTTTGCACCCGGTCGTTTTGCGGGAGTTCGGGAA
ACTGACTTTCTTCATTGGGGACATTGTAATTTTCTGATGATGCCACGAGGAGAAAAAAAATACGGGTTTGTTTTAATTGGAAGGACCTTC
CGCTTTTATGATTTCGGTTTACCTTGGAAAACTGAATCTTCTGTGTTTTATTTCTTTCCTCTAGTACTAGAAAAGCAATGAATTAATTGC
ACAAAACAGGTTCTGAGACGGCCCGCAGGCCCCGAGCTCGTGGACGCGGCCGAGGGTCGGGTGTGACCCGCGGAGCCGCTGCCAGGCTTC
CCAGCTCGTCTTCGCGGGGAGGCGGGAGGCAGGACCAGACCCCAGCATTTCAGCGTGAAAGTCTTCGCCTTTCTTTCCGCGCTGTCTTTC
CCGCGGGCGGAGCGGCGTACCTGAGCGCGGTCCCCACGGAGGATCAGTGACTTTCCCAGACCCCGCGGGCGAGCCCGCGCTTGGGACCCG
GCAGCTCTGCGCGGGCTGGTTTTGGAGGGGGTGGTGTTCGTTTGTTTAAATTCCAGTTGTTATTTGGCAGCATATCGCCTTCCGAGTCAG
TAAGAATTGCCCACGACGTAAAGAGCGACTTGCAGGAAGGGGCCGAAGCCGTCGTTAGCGCCCGGGCGGCGGCGGCCACTCGAACCCCGT
TTCCGCCAAGCGCGCTGCAACCTGCGGGGCGAGTTCGTTTTGTTTTGCCAAAATCATTTGGGGACTTCTTTGTCATTCATGCCCTTCCTT
TTAAATGATTTTTATTTTTTTCCACTGTAAGTGACCGGCTGGGTTTGACTTTTGCTTCTTCCGACGGAAGGGCACCGCGAGCCGGGGTGG
GCGGCCCCGCGGGCAGGAGGAGCGCGGGGTACACGCGGTGGCCGCAGACGCCGAGCCCTGCGGAGCCCCGAGGCCTCGTCGCCCGCGCCC
CCGGTGCGCGCGGAGCCGGGGCCGAGGCCGGGCCAGGAGGAGTGTGGCGGCCCAGGAGGCCTGGACTGTGGGCCCTGCTCGCCCGCCCGC
CGCGGGCCGCCCGGAGCCCGCGCGCCTGTCGCGCAGCCCGGCTGTAATGGTGGCAGATCAAAGGCGGCCCCGTGTCCCCGCGGAGCCCGG
GACAATCCCGCGCCTTTGTGCGCTGTTGCTAGGAGCCCGAGAAACTAAGAGAAAGTGTCAGGAGCATGTTAATCAGACTCGTTACACTGT
AACAATAACGTCTCTCTCGGGTCTCCCAGGCCCCAGTACCCCCGCGCACCCTGCGCGCAGGCCGGACACCTGCGCAGGGCCCTTGCGCCC
GCCCTGGGGTCCCGCCGGCCCTGGGGTCCCTGCAGCCCCGAATCCGCACCCGAGCCACGCGGAACGACTAGCCCCGAGGGGCCCCGCAGG
CTCCCGGTGCAGCTCCCTGGTCGTGGTCTCCTTGACCGAAGCCCCGGCCTCACACCGCCTGGCCGCGAGCCCGAGGGACGCAGGGACGAT
CCCGGTCCCCTGCTTTTCAGTCCTCCAGTCGAATCGCCCACTTTGTTCAATCACAGTATTCGAATCAAGAGGAAAATGAACATTCCCTTT
ATGGTAGCTTTTTGGTTATGAGTTTTGGCAAAACTGTTAAATCAACTTTGCCGATTTCCCTTGGGAATCCCTGGAGGCCACTCTAAGTGG
TAATCCCAAGTTTAAGAAGGAAATGGGGAAATTTTGCTGAGAGTAAAGATGTCGCCGAACTTTTTGAAGGGATTTGCTTCATTCATTCAT
TTAGTCATTCAACAGACACCTGTTGAACCCGACTGGGTGCCAGAGGGGCCAGTCACAGGACTTATTCCAGATGAACTTTTCTTTTGAAAT
TAGAATGCCCTTGTGGAAGCCAAAGGAGGAGCAGAGGCCTAAAATAATGTCAAGTGTCAAAGCAAAAAGAAGTGCCATTGGCTACTACAG

>85455_85455_3_SPAG9-CLYBL_SPAG9_chr17_49197715_ENST00000505279_CLYBL_chr13_100543572_ENST00000376355_length(amino acids)=167AA_BP=
MSRSPAVMVADQRRPRVPAEPGTIPRLCALLLGARETKRKCQEHVNQTRYTVTITSLSGLPGPSTPAHPARRPDTCAGPLRPPWGPAGPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPAG9-CLYBL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPAG9-CLYBL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPAG9-CLYBL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource