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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPAST-MEMO1 (FusionGDB2 ID:85531)

Fusion Gene Summary for SPAST-MEMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPAST-MEMO1
Fusion gene ID: 85531
HgeneTgene
Gene symbol

SPAST

MEMO1

Gene ID

6683

51072

Gene namespastinmediator of cell motility 1
SynonymsADPSP|FSP2|SPG4C2orf4|CGI-27|MEMO|NS5ATP7
Cytomap

2p22.3

2p22.3

Type of geneprotein-codingprotein-coding
Descriptionspastinspastic paraplegia 4 (autosomal dominant; spastin)spastic paraplegia 4 proteinprotein MEMO1C21orf19-like proteinHCV NS5A-transactivated protein 7hepatitis C virus NS5A-transactivated protein 7mediator of ErbB2-driven cell motility 1
Modification date2020032220200329
UniProtAcc.

Q9Y316

Ensembl transtripts involved in fusion geneENST00000315285, ENST00000345662, 
ENST00000407893, ENST00000426310, 
ENST00000490459, ENST00000295065, 
ENST00000379383, ENST00000404530, 
Fusion gene scores* DoF score6 X 4 X 7=1683 X 3 X 3=27
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPAST [Title/Abstract] AND MEMO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPAST(32289315)-MEMO1(32168452), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPAST

GO:0001578

microtubule bundle formation

16219033

HgeneSPAST

GO:0034214

protein hexamerization

17389232

HgeneSPAST

GO:0051013

microtubule severing

15716377|16219033|17389232|23745751|26875866

HgeneSPAST

GO:0051260

protein homooligomerization

17389232


check buttonFusion gene breakpoints across SPAST (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MEMO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7737SPASTchr2

32314674

+MEMO1chr2

32168452

-
ChimerDB4STADTCGA-HU-A4GF-01ASPASTchr2

32289315

+MEMO1chr2

32168452

-
ChimerDB4STADTCGA-HU-A4GFSPASTchr2

32289315

+MEMO1chr2

32168452

-


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Fusion Gene ORF analysis for SPAST-MEMO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000315285ENST00000407893SPASTchr2

32314674

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000407893SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000426310SPASTchr2

32314674

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000426310SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000490459SPASTchr2

32314674

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000315285ENST00000490459SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000407893SPASTchr2

32314674

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000407893SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000426310SPASTchr2

32314674

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000426310SPASTchr2

32289315

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000490459SPASTchr2

32314674

+MEMO1chr2

32168452

-
5CDS-5UTRENST00000345662ENST00000490459SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000295065SPASTchr2

32314674

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000295065SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000379383SPASTchr2

32314674

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000379383SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000404530SPASTchr2

32314674

+MEMO1chr2

32168452

-
In-frameENST00000315285ENST00000404530SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000295065SPASTchr2

32314674

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000295065SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000379383SPASTchr2

32314674

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000379383SPASTchr2

32289315

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000404530SPASTchr2

32314674

+MEMO1chr2

32168452

-
In-frameENST00000345662ENST00000404530SPASTchr2

32289315

+MEMO1chr2

32168452

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345662SPASTchr232289315+ENST00000295065MEMO1chr232168452-47706362211468415
ENST00000345662SPASTchr232289315+ENST00000379383MEMO1chr232168452-20076362211468415
ENST00000345662SPASTchr232289315+ENST00000404530MEMO1chr232168452-20076362211468415
ENST00000315285SPASTchr232289315+ENST00000295065MEMO1chr232168452-46745401251372415
ENST00000315285SPASTchr232289315+ENST00000379383MEMO1chr232168452-19115401251372415
ENST00000315285SPASTchr232289315+ENST00000404530MEMO1chr232168452-19115401251372415
ENST00000345662SPASTchr232314674+ENST00000295065MEMO1chr232168452-49418072211639472
ENST00000345662SPASTchr232314674+ENST00000379383MEMO1chr232168452-21788072211639472
ENST00000345662SPASTchr232314674+ENST00000404530MEMO1chr232168452-21788072211639472
ENST00000315285SPASTchr232314674+ENST00000295065MEMO1chr232168452-48457111251543472
ENST00000315285SPASTchr232314674+ENST00000379383MEMO1chr232168452-20827111251543472
ENST00000315285SPASTchr232314674+ENST00000404530MEMO1chr232168452-20827111251543472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345662ENST00000295065SPASTchr232289315+MEMO1chr232168452-0.0003160710.999684
ENST00000345662ENST00000379383SPASTchr232289315+MEMO1chr232168452-0.0024136810.99758637
ENST00000345662ENST00000404530SPASTchr232289315+MEMO1chr232168452-0.0024136810.99758637
ENST00000315285ENST00000295065SPASTchr232289315+MEMO1chr232168452-0.0003069220.99969316
ENST00000315285ENST00000379383SPASTchr232289315+MEMO1chr232168452-0.0019410190.998059
ENST00000315285ENST00000404530SPASTchr232289315+MEMO1chr232168452-0.0019410190.998059
ENST00000345662ENST00000295065SPASTchr232314674+MEMO1chr232168452-0.000355150.9996449
ENST00000345662ENST00000379383SPASTchr232314674+MEMO1chr232168452-0.0029197840.99708015
ENST00000345662ENST00000404530SPASTchr232314674+MEMO1chr232168452-0.0029197840.99708015
ENST00000315285ENST00000295065SPASTchr232314674+MEMO1chr232168452-0.0003453550.99965465
ENST00000315285ENST00000379383SPASTchr232314674+MEMO1chr232168452-0.0023506550.9976494
ENST00000315285ENST00000404530SPASTchr232314674+MEMO1chr232168452-0.0023506550.9976494

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Fusion Genomic Features for SPAST-MEMO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPAST-MEMO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:32289315/chr2:32168452)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MEMO1

Q9Y316

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+317120_195195617.0DomainMIT
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+316120_195195585.0DomainMIT
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+11757_77138617.0IntramembraneHelical
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+11657_77138585.0IntramembraneHelical
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+31757_77195617.0IntramembraneHelical
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+31657_77195585.0IntramembraneHelical
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1174_11138617.0MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+11759_67138617.0MotifNuclear export signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1164_11138585.0MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+11659_67138585.0MotifNuclear export signal
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+3174_11195617.0MotifNuclear localization signal
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+31759_67195617.0MotifNuclear export signal
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+3164_11195585.0MotifNuclear localization signal
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+31659_67195585.0MotifNuclear export signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1171_50138617.0RegionRequired for nuclear localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1161_50138585.0RegionRequired for nuclear localization
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+3171_194195617.0RegionRequired for midbody localization
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+3171_50195617.0RegionRequired for nuclear localization
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+3161_194195585.0RegionRequired for midbody localization
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+3161_50195585.0RegionRequired for nuclear localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1171_56138617.0Topological domainCytoplasmic
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1161_56138585.0Topological domainCytoplasmic
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+3171_56195617.0Topological domainCytoplasmic
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+3161_56195585.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117120_195138617.0DomainMIT
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116120_195138585.0DomainMIT
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117309_312138617.0MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116309_312138585.0MotifNuclear localization signal
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+317309_312195617.0MotifNuclear localization signal
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+316309_312195585.0MotifNuclear localization signal
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117382_389138617.0Nucleotide bindingATP
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116382_389138585.0Nucleotide bindingATP
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+317382_389195617.0Nucleotide bindingATP
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+316382_389195585.0Nucleotide bindingATP
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+1171_194138617.0RegionRequired for midbody localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+117228_616138617.0RegionSufficient for microtubule severing
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+1161_194138585.0RegionRequired for midbody localization
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+116228_616138585.0RegionSufficient for microtubule severing
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+317228_616195617.0RegionSufficient for microtubule severing
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+316228_616195585.0RegionSufficient for microtubule severing
HgeneSPASTchr2:32289315chr2:32168452ENST00000315285+11778_616138617.0Topological domainCytoplasmic
HgeneSPASTchr2:32289315chr2:32168452ENST00000345662+11678_616138585.0Topological domainCytoplasmic
HgeneSPASTchr2:32314674chr2:32168452ENST00000315285+31778_616195617.0Topological domainCytoplasmic
HgeneSPASTchr2:32314674chr2:32168452ENST00000345662+31678_616195585.0Topological domainCytoplasmic


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Fusion Gene Sequence for SPAST-MEMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85531_85531_1_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000315285_MEMO1_chr2_32168452_ENST00000295065_length(transcript)=4674nt_BP=540nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
GACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAG
GATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTC
ATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACG
GAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAG
CTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAA
AACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTT
ACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTAT
CTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGA
AGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAG
CTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTT
TACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTC
CTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAA
TGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTG
CACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATA
AATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAAT
AAAGGGCTACACAACTCAAAATAGTCTGATTTAAACTTATTGCTCTGTGGTATATATGAAAATTGTTTTTTATTAATTCCATCTCAGAAT
TTTTGTTAAAAATGGTAAACCTCAGCTCTTATGTAAAAATATATTAGGATGTATTTTATATTTTATATATTTGTATGATTTTTTTAAATC
AGAAATTAGAATCATATGATCTTAAAGTTAACTTTTTAAATTACATGCAGTTTGCCTTTTTGTCTGTGACATCCCTTTGTGTCATTACTA
TATTGTAACAGAATATATATTCAAGATTGGTAAAAGAACGTAGATGTAATCCTTGACTTCAAAGATCATGTTTGATAGTCTGCAAATGAG
GAAACATTGAAGAGTGTTCTTAGTGTTTTTCAAATCATTGCAGACCTTACACTGCTGTGCTTTTTTAATGCTTTAAGCAGTTTGACTCTT
TTACTTGAATTTTTAGCCAGAGATCATTAACATCATCAACAACAACAAGCCACTGGATTTTCTTATGGTTACACAATTTTTTTTGTCATG
ATTTTTGGTGCGGCTCTTCCAACTAAAATAATGGTATGATGTTGTATTTCTTTCTTTCTTTAGCATAGACCAATTCTAGTCACTTTCGCC
AAAAAAAAAAAAAAAAAAAAAAAAAAGATATAATTTAGTTAATAATTCAGTTACCATGTATGTACTGCATTATACCTATTTTAACCTAAC
AGTGTCTACATTATATTAGAGAGTGTTTATATCTCCAGTGTTATGCCAGAGTAGCACAATTTTTAGATGCCTTGCACCAATTTTATTTAA
AGATTTATGTTTCTTATTTATTAAATATCAACTTTCTATACTCGAGTGAAATAAAATAATGTTACCTTTTAGATTCAAAGTCGCCCACCT
ATGTATGTGTGGAAATTATATTCTTACACATTAGTGATTTATTTTCCGTAATTTAGATACACTTTTTAGTACTATTAATATTTATTTCTT
GTTTAATATGAACTATAAAATTTTAAAATGGACAACAGTGAATTTTTAAAATAATGTTTTCTGAGTATAAGACTAATACATGATTATTTT
AGAAAATTTGAAAATTACTGAAAAGTTATAAAGAGAAAAAATTATCTGCAATCTCACTACCCAGAGATAACCCTGTTAATATTTTTCTGT
ATTTCTTTTCAGTCTTTGTCTGTGCTATTTCTATGTATGAGTGTGTATACATGTGTTTGTGTGTGTGTGTAATAACAAACTTGAGATTAT
ACTGACCATATAGTTATGTACCCTGTTTTTTATAACCTAACTTCATACATATTTACCCATGTCTATGAAAATGTGACTTTTAAAAATGGC
TGCCTAATATTCTATTGTATGAATATGCCACAATTTAACTACTTCTCTCTTTGGATATTAGGTTGTTCTAATCTTTCACCATTATAAATA
ATAGTGGGATAGACATCCTTGTTTGTAAAATTTCATCTCTATATTAGACTCTTTAGGATATACTCATGTACATGGAATAAGTGGTTTAGA
CAGTGAGAACTTTTTAGGCTCTTTAAAATATTTCCAAGTTATAACCCTTTAGAAAGATTGTACTAAATTAACAATGTATGAGTACCCATC
ATTCTGCCCCTTCACCAGTATCATTATTTTTTTAATCTTTGACAGTTGGTTAACATAACAATCGGTTGTTTCTTTGACCATTCTAATAAG
AGTTGCTTTATAATGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGA
TCGAGACCATCCCGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGTGGCGGAGCCTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCT
GGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGCTTTATAATTAATTATTTTTGTCTTTCTATAA
TTTTATAGTTGATTGATTTTTAAAAAGACAAGAGGGTTGCCTAAGTTGGGTGGACTATAGTACAAGTATGGTTCTTGCACTTTTAAAACT
GTAGAAGCTGGACACGATGGTATGCACCTGTAGTCCCAGCTACTTTGACTGTGGAGGCAGGAGGATCACTTGACAGTTTGAGACCAGCCT
GGGCAATGTAGTGAGCCCCCCAAAACCCTCTAAACAAACAAACAAATCTGCAGAATATTTCAGCATCACTCTACACTTTCCTAGAATATC
AACATACCTGATAATGAAGTAGAAAGAGTTCCAAATTGATGATTGAGTGTTGGGTTCTAGTTCTATTTCTGCCACTAATTAGTTCTCTGA
ACTTAAGTGTTTCATGTCATATTGAAACTTTCTCATTTGTAAAATGTGGAGGGGATCTCTTAAGTGCTTTCTAGTTTCAAAGTACTTTGA
TACTGTGACTTTATTTTGTAGAGGTTCTGGTGTCATTTATTTTTAATAGCTACATGAATAATGTAGAGATACTATCTTTTGATTTCAACT
TCACATACATGGAAATGAAAGTCTTGTTATTTAACACAAAAGGAAATTTAATTTGCATTATTTAATGCAGTTAATATTACCTAAAATGTT

>85531_85531_1_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000315285_MEMO1_chr2_32168452_ENST00000295065_length(amino acids)=415AA_BP=138
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

--------------------------------------------------------------
>85531_85531_2_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000315285_MEMO1_chr2_32168452_ENST00000379383_length(transcript)=1911nt_BP=540nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
GACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAG
GATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTC
ATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACG
GAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAG
CTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAA
AACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTT
ACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTAT
CTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGA
AGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAG
CTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTT
TACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTC
CTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAA
TGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTG
CACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATA
AATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAAT

>85531_85531_2_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000315285_MEMO1_chr2_32168452_ENST00000379383_length(amino acids)=415AA_BP=138
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

--------------------------------------------------------------
>85531_85531_3_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000315285_MEMO1_chr2_32168452_ENST00000404530_length(transcript)=1911nt_BP=540nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
GACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAG
GATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTC
ATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACG
GAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAG
CTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAA
AACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTT
ACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTAT
CTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGA
AGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAG
CTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTT
TACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTC
CTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAA
TGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTG
CACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATA
AATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAAT

>85531_85531_3_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000315285_MEMO1_chr2_32168452_ENST00000404530_length(amino acids)=415AA_BP=138
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

--------------------------------------------------------------
>85531_85531_4_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000345662_MEMO1_chr2_32168452_ENST00000295065_length(transcript)=4770nt_BP=636nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCC
ATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGC
CTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGA
TTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTT
ATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAAT
TCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTT
ACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACC
CTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGC
TCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTT
ATGCAGCTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCT
AGCCTTTACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAG
TCCTTCCTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGA
TGACAATGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGA
CTTGTGCACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCA
TTTATAAATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTT
GCTAATAAAGGGCTACACAACTCAAAATAGTCTGATTTAAACTTATTGCTCTGTGGTATATATGAAAATTGTTTTTTATTAATTCCATCT
CAGAATTTTTGTTAAAAATGGTAAACCTCAGCTCTTATGTAAAAATATATTAGGATGTATTTTATATTTTATATATTTGTATGATTTTTT
TAAATCAGAAATTAGAATCATATGATCTTAAAGTTAACTTTTTAAATTACATGCAGTTTGCCTTTTTGTCTGTGACATCCCTTTGTGTCA
TTACTATATTGTAACAGAATATATATTCAAGATTGGTAAAAGAACGTAGATGTAATCCTTGACTTCAAAGATCATGTTTGATAGTCTGCA
AATGAGGAAACATTGAAGAGTGTTCTTAGTGTTTTTCAAATCATTGCAGACCTTACACTGCTGTGCTTTTTTAATGCTTTAAGCAGTTTG
ACTCTTTTACTTGAATTTTTAGCCAGAGATCATTAACATCATCAACAACAACAAGCCACTGGATTTTCTTATGGTTACACAATTTTTTTT
GTCATGATTTTTGGTGCGGCTCTTCCAACTAAAATAATGGTATGATGTTGTATTTCTTTCTTTCTTTAGCATAGACCAATTCTAGTCACT
TTCGCCAAAAAAAAAAAAAAAAAAAAAAAAAAGATATAATTTAGTTAATAATTCAGTTACCATGTATGTACTGCATTATACCTATTTTAA
CCTAACAGTGTCTACATTATATTAGAGAGTGTTTATATCTCCAGTGTTATGCCAGAGTAGCACAATTTTTAGATGCCTTGCACCAATTTT
ATTTAAAGATTTATGTTTCTTATTTATTAAATATCAACTTTCTATACTCGAGTGAAATAAAATAATGTTACCTTTTAGATTCAAAGTCGC
CCACCTATGTATGTGTGGAAATTATATTCTTACACATTAGTGATTTATTTTCCGTAATTTAGATACACTTTTTAGTACTATTAATATTTA
TTTCTTGTTTAATATGAACTATAAAATTTTAAAATGGACAACAGTGAATTTTTAAAATAATGTTTTCTGAGTATAAGACTAATACATGAT
TATTTTAGAAAATTTGAAAATTACTGAAAAGTTATAAAGAGAAAAAATTATCTGCAATCTCACTACCCAGAGATAACCCTGTTAATATTT
TTCTGTATTTCTTTTCAGTCTTTGTCTGTGCTATTTCTATGTATGAGTGTGTATACATGTGTTTGTGTGTGTGTGTAATAACAAACTTGA
GATTATACTGACCATATAGTTATGTACCCTGTTTTTTATAACCTAACTTCATACATATTTACCCATGTCTATGAAAATGTGACTTTTAAA
AATGGCTGCCTAATATTCTATTGTATGAATATGCCACAATTTAACTACTTCTCTCTTTGGATATTAGGTTGTTCTAATCTTTCACCATTA
TAAATAATAGTGGGATAGACATCCTTGTTTGTAAAATTTCATCTCTATATTAGACTCTTTAGGATATACTCATGTACATGGAATAAGTGG
TTTAGACAGTGAGAACTTTTTAGGCTCTTTAAAATATTTCCAAGTTATAACCCTTTAGAAAGATTGTACTAAATTAACAATGTATGAGTA
CCCATCATTCTGCCCCTTCACCAGTATCATTATTTTTTTAATCTTTGACAGTTGGTTAACATAACAATCGGTTGTTTCTTTGACCATTCT
AATAAGAGTTGCTTTATAATGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTC
AGGAGATCGAGACCATCCCGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGT
AGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGTGGCGGAGCCTGCAGTGAGCCGAGATCCCGCCACTGCACTC
CAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGCTTTATAATTAATTATTTTTGTCTTT
CTATAATTTTATAGTTGATTGATTTTTAAAAAGACAAGAGGGTTGCCTAAGTTGGGTGGACTATAGTACAAGTATGGTTCTTGCACTTTT
AAAACTGTAGAAGCTGGACACGATGGTATGCACCTGTAGTCCCAGCTACTTTGACTGTGGAGGCAGGAGGATCACTTGACAGTTTGAGAC
CAGCCTGGGCAATGTAGTGAGCCCCCCAAAACCCTCTAAACAAACAAACAAATCTGCAGAATATTTCAGCATCACTCTACACTTTCCTAG
AATATCAACATACCTGATAATGAAGTAGAAAGAGTTCCAAATTGATGATTGAGTGTTGGGTTCTAGTTCTATTTCTGCCACTAATTAGTT
CTCTGAACTTAAGTGTTTCATGTCATATTGAAACTTTCTCATTTGTAAAATGTGGAGGGGATCTCTTAAGTGCTTTCTAGTTTCAAAGTA
CTTTGATACTGTGACTTTATTTTGTAGAGGTTCTGGTGTCATTTATTTTTAATAGCTACATGAATAATGTAGAGATACTATCTTTTGATT
TCAACTTCACATACATGGAAATGAAAGTCTTGTTATTTAACACAAAAGGAAATTTAATTTGCATTATTTAATGCAGTTAATATTACCTAA
AATGTTGAACTTAAGCTTTTCTACTTTAAGTGCCTTTAAAAGTTTTGTATTTGGAATCTAAAATATAAAGGAAATTCTTATGTAGCTCTA

>85531_85531_4_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000345662_MEMO1_chr2_32168452_ENST00000295065_length(amino acids)=415AA_BP=138
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

--------------------------------------------------------------
>85531_85531_5_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000345662_MEMO1_chr2_32168452_ENST00000379383_length(transcript)=2007nt_BP=636nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCC
ATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGC
CTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGA
TTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTT
ATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAAT
TCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTT
ACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACC
CTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGC
TCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTT
ATGCAGCTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCT
AGCCTTTACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAG
TCCTTCCTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGA
TGACAATGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGA
CTTGTGCACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCA
TTTATAAATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTT

>85531_85531_5_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000345662_MEMO1_chr2_32168452_ENST00000379383_length(amino acids)=415AA_BP=138
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

--------------------------------------------------------------
>85531_85531_6_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000345662_MEMO1_chr2_32168452_ENST00000404530_length(transcript)=2007nt_BP=636nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGGACCGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCC
ATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGC
CTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGA
TTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTT
ATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAAT
TCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTT
ACAGTTACTATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACC
CTGTATCTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGC
TCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTT
ATGCAGCTGGAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCT
AGCCTTTACCACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAG
TCCTTCCTTAATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGA
TGACAATGTAAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGA
CTTGTGCACATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCA
TTTATAAATGATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTT

>85531_85531_6_SPAST-MEMO1_SPAST_chr2_32289315_ENST00000345662_MEMO1_chr2_32168452_ENST00000404530_length(amino acids)=415AA_BP=138
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHA
YKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFT
IIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNT

--------------------------------------------------------------
>85531_85531_7_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000315285_MEMO1_chr2_32168452_ENST00000295065_length(transcript)=4845nt_BP=711nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
CAGGACAGAAGGAGCAAGCTGTGGAATGGTATAAGAAAGGTATTGAAGAACTGGAAAAAGGAATAGCTGTTATAGTTACAGGACAAGGTG
AACAGTGTGAAAGAGCTAGACGCCTTCAAGCTAAAATGATGACTAATTTGGTTATGGCCAAGGACCGCTTACAACTTCTAGGACCGCAGC
TGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGT
ACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGC
CCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGT
GGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCA
TGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCA
GTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATG
AATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCA
ATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAA
TGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAGCTGGAGCAC
TCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTTTACCACGAT
ACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTCCTTAATTTC
AACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAATGTAAAGGC
TCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTGCACATATAT
TCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATAAATGATCTG
TATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAATAAAGGGCTA
CACAACTCAAAATAGTCTGATTTAAACTTATTGCTCTGTGGTATATATGAAAATTGTTTTTTATTAATTCCATCTCAGAATTTTTGTTAA
AAATGGTAAACCTCAGCTCTTATGTAAAAATATATTAGGATGTATTTTATATTTTATATATTTGTATGATTTTTTTAAATCAGAAATTAG
AATCATATGATCTTAAAGTTAACTTTTTAAATTACATGCAGTTTGCCTTTTTGTCTGTGACATCCCTTTGTGTCATTACTATATTGTAAC
AGAATATATATTCAAGATTGGTAAAAGAACGTAGATGTAATCCTTGACTTCAAAGATCATGTTTGATAGTCTGCAAATGAGGAAACATTG
AAGAGTGTTCTTAGTGTTTTTCAAATCATTGCAGACCTTACACTGCTGTGCTTTTTTAATGCTTTAAGCAGTTTGACTCTTTTACTTGAA
TTTTTAGCCAGAGATCATTAACATCATCAACAACAACAAGCCACTGGATTTTCTTATGGTTACACAATTTTTTTTGTCATGATTTTTGGT
GCGGCTCTTCCAACTAAAATAATGGTATGATGTTGTATTTCTTTCTTTCTTTAGCATAGACCAATTCTAGTCACTTTCGCCAAAAAAAAA
AAAAAAAAAAAAAAAAAGATATAATTTAGTTAATAATTCAGTTACCATGTATGTACTGCATTATACCTATTTTAACCTAACAGTGTCTAC
ATTATATTAGAGAGTGTTTATATCTCCAGTGTTATGCCAGAGTAGCACAATTTTTAGATGCCTTGCACCAATTTTATTTAAAGATTTATG
TTTCTTATTTATTAAATATCAACTTTCTATACTCGAGTGAAATAAAATAATGTTACCTTTTAGATTCAAAGTCGCCCACCTATGTATGTG
TGGAAATTATATTCTTACACATTAGTGATTTATTTTCCGTAATTTAGATACACTTTTTAGTACTATTAATATTTATTTCTTGTTTAATAT
GAACTATAAAATTTTAAAATGGACAACAGTGAATTTTTAAAATAATGTTTTCTGAGTATAAGACTAATACATGATTATTTTAGAAAATTT
GAAAATTACTGAAAAGTTATAAAGAGAAAAAATTATCTGCAATCTCACTACCCAGAGATAACCCTGTTAATATTTTTCTGTATTTCTTTT
CAGTCTTTGTCTGTGCTATTTCTATGTATGAGTGTGTATACATGTGTTTGTGTGTGTGTGTAATAACAAACTTGAGATTATACTGACCAT
ATAGTTATGTACCCTGTTTTTTATAACCTAACTTCATACATATTTACCCATGTCTATGAAAATGTGACTTTTAAAAATGGCTGCCTAATA
TTCTATTGTATGAATATGCCACAATTTAACTACTTCTCTCTTTGGATATTAGGTTGTTCTAATCTTTCACCATTATAAATAATAGTGGGA
TAGACATCCTTGTTTGTAAAATTTCATCTCTATATTAGACTCTTTAGGATATACTCATGTACATGGAATAAGTGGTTTAGACAGTGAGAA
CTTTTTAGGCTCTTTAAAATATTTCCAAGTTATAACCCTTTAGAAAGATTGTACTAAATTAACAATGTATGAGTACCCATCATTCTGCCC
CTTCACCAGTATCATTATTTTTTTAATCTTTGACAGTTGGTTAACATAACAATCGGTTGTTTCTTTGACCATTCTAATAAGAGTTGCTTT
ATAATGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCA
TCCCGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGTAGTCCCAGCTACTTG
GGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGTGGCGGAGCCTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCTGGGCGACAG
AGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGCTTTATAATTAATTATTTTTGTCTTTCTATAATTTTATAGT
TGATTGATTTTTAAAAAGACAAGAGGGTTGCCTAAGTTGGGTGGACTATAGTACAAGTATGGTTCTTGCACTTTTAAAACTGTAGAAGCT
GGACACGATGGTATGCACCTGTAGTCCCAGCTACTTTGACTGTGGAGGCAGGAGGATCACTTGACAGTTTGAGACCAGCCTGGGCAATGT
AGTGAGCCCCCCAAAACCCTCTAAACAAACAAACAAATCTGCAGAATATTTCAGCATCACTCTACACTTTCCTAGAATATCAACATACCT
GATAATGAAGTAGAAAGAGTTCCAAATTGATGATTGAGTGTTGGGTTCTAGTTCTATTTCTGCCACTAATTAGTTCTCTGAACTTAAGTG
TTTCATGTCATATTGAAACTTTCTCATTTGTAAAATGTGGAGGGGATCTCTTAAGTGCTTTCTAGTTTCAAAGTACTTTGATACTGTGAC
TTTATTTTGTAGAGGTTCTGGTGTCATTTATTTTTAATAGCTACATGAATAATGTAGAGATACTATCTTTTGATTTCAACTTCACATACA
TGGAAATGAAAGTCTTGTTATTTAACACAAAAGGAAATTTAATTTGCATTATTTAATGCAGTTAATATTACCTAAAATGTTGAACTTAAG

>85531_85531_7_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000315285_MEMO1_chr2_32168452_ENST00000295065_length(amino acids)=472AA_BP=195
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
MMTNLVMAKDRLQLLGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDI
YRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFV
VSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQ

--------------------------------------------------------------
>85531_85531_8_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000315285_MEMO1_chr2_32168452_ENST00000379383_length(transcript)=2082nt_BP=711nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
CAGGACAGAAGGAGCAAGCTGTGGAATGGTATAAGAAAGGTATTGAAGAACTGGAAAAAGGAATAGCTGTTATAGTTACAGGACAAGGTG
AACAGTGTGAAAGAGCTAGACGCCTTCAAGCTAAAATGATGACTAATTTGGTTATGGCCAAGGACCGCTTACAACTTCTAGGACCGCAGC
TGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGT
ACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGC
CCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGT
GGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCA
TGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCA
GTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATG
AATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCA
ATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAA
TGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAGCTGGAGCAC
TCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTTTACCACGAT
ACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTCCTTAATTTC
AACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAATGTAAAGGC
TCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTGCACATATAT
TCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATAAATGATCTG
TATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAATAAAGGGCTA

>85531_85531_8_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000315285_MEMO1_chr2_32168452_ENST00000379383_length(amino acids)=472AA_BP=195
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
MMTNLVMAKDRLQLLGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDI
YRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFV
VSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQ

--------------------------------------------------------------
>85531_85531_9_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000315285_MEMO1_chr2_32168452_ENST00000404530_length(transcript)=2082nt_BP=711nt
GCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTGCGGGAG
GCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCAGCAACC
CGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATAAGCGGA
ACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGTGGCTCT
GCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGCCGGTGC
CGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATGAGAAAG
CAGGACAGAAGGAGCAAGCTGTGGAATGGTATAAGAAAGGTATTGAAGAACTGGAAAAAGGAATAGCTGTTATAGTTACAGGACAAGGTG
AACAGTGTGAAAGAGCTAGACGCCTTCAAGCTAAAATGATGACTAATTTGGTTATGGCCAAGGACCGCTTACAACTTCTAGGACCGCAGC
TGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGATATACGT
ACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGC
CCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGT
GGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCA
TGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCA
GTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATG
AATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTTTTAGCA
ATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGAATGGAA
TGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAGCTGGAGCAC
TCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTTTACCACGAT
ACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTCCTTAATTTC
AACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAATGTAAAGGC
TCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTGCACATATAT
TCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATAAATGATCTG
TATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAATAAAGGGCTA

>85531_85531_9_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000315285_MEMO1_chr2_32168452_ENST00000404530_length(amino acids)=472AA_BP=195
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
MMTNLVMAKDRLQLLGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDI
YRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFV
VSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQ

--------------------------------------------------------------
>85531_85531_10_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000345662_MEMO1_chr2_32168452_ENST00000295065_length(transcript)=4941nt_BP=807nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGCAGGACAGAAGGAGCAAGCTGTGGAATGGTATAAGAAAGGTATTGAAGAACTGGAAAAAGGAATAGCTGTTATAGTTACAGGAC
AAGGTGAACAGTGTGAAAGAGCTAGACGCCTTCAAGCTAAAATGATGACTAATTTGGTTATGGCCAAGGACCGCTTACAACTTCTAGGAC
CGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGAT
ATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATC
ATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAG
AACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTA
AAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAAC
TCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACT
ATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTT
TTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGA
ATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAGCTG
GAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTTTAC
CACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTCCTT
AATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAATGT
AAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTGCAC
ATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATAAAT
GATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAATAAA
GGGCTACACAACTCAAAATAGTCTGATTTAAACTTATTGCTCTGTGGTATATATGAAAATTGTTTTTTATTAATTCCATCTCAGAATTTT
TGTTAAAAATGGTAAACCTCAGCTCTTATGTAAAAATATATTAGGATGTATTTTATATTTTATATATTTGTATGATTTTTTTAAATCAGA
AATTAGAATCATATGATCTTAAAGTTAACTTTTTAAATTACATGCAGTTTGCCTTTTTGTCTGTGACATCCCTTTGTGTCATTACTATAT
TGTAACAGAATATATATTCAAGATTGGTAAAAGAACGTAGATGTAATCCTTGACTTCAAAGATCATGTTTGATAGTCTGCAAATGAGGAA
ACATTGAAGAGTGTTCTTAGTGTTTTTCAAATCATTGCAGACCTTACACTGCTGTGCTTTTTTAATGCTTTAAGCAGTTTGACTCTTTTA
CTTGAATTTTTAGCCAGAGATCATTAACATCATCAACAACAACAAGCCACTGGATTTTCTTATGGTTACACAATTTTTTTTGTCATGATT
TTTGGTGCGGCTCTTCCAACTAAAATAATGGTATGATGTTGTATTTCTTTCTTTCTTTAGCATAGACCAATTCTAGTCACTTTCGCCAAA
AAAAAAAAAAAAAAAAAAAAAAAGATATAATTTAGTTAATAATTCAGTTACCATGTATGTACTGCATTATACCTATTTTAACCTAACAGT
GTCTACATTATATTAGAGAGTGTTTATATCTCCAGTGTTATGCCAGAGTAGCACAATTTTTAGATGCCTTGCACCAATTTTATTTAAAGA
TTTATGTTTCTTATTTATTAAATATCAACTTTCTATACTCGAGTGAAATAAAATAATGTTACCTTTTAGATTCAAAGTCGCCCACCTATG
TATGTGTGGAAATTATATTCTTACACATTAGTGATTTATTTTCCGTAATTTAGATACACTTTTTAGTACTATTAATATTTATTTCTTGTT
TAATATGAACTATAAAATTTTAAAATGGACAACAGTGAATTTTTAAAATAATGTTTTCTGAGTATAAGACTAATACATGATTATTTTAGA
AAATTTGAAAATTACTGAAAAGTTATAAAGAGAAAAAATTATCTGCAATCTCACTACCCAGAGATAACCCTGTTAATATTTTTCTGTATT
TCTTTTCAGTCTTTGTCTGTGCTATTTCTATGTATGAGTGTGTATACATGTGTTTGTGTGTGTGTGTAATAACAAACTTGAGATTATACT
GACCATATAGTTATGTACCCTGTTTTTTATAACCTAACTTCATACATATTTACCCATGTCTATGAAAATGTGACTTTTAAAAATGGCTGC
CTAATATTCTATTGTATGAATATGCCACAATTTAACTACTTCTCTCTTTGGATATTAGGTTGTTCTAATCTTTCACCATTATAAATAATA
GTGGGATAGACATCCTTGTTTGTAAAATTTCATCTCTATATTAGACTCTTTAGGATATACTCATGTACATGGAATAAGTGGTTTAGACAG
TGAGAACTTTTTAGGCTCTTTAAAATATTTCCAAGTTATAACCCTTTAGAAAGATTGTACTAAATTAACAATGTATGAGTACCCATCATT
CTGCCCCTTCACCAGTATCATTATTTTTTTAATCTTTGACAGTTGGTTAACATAACAATCGGTTGTTTCTTTGACCATTCTAATAAGAGT
TGCTTTATAATGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCG
AGACCATCCCGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGTAGTCCCAGC
TACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGTGGCGGAGCCTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCTGGG
CGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGCTTTATAATTAATTATTTTTGTCTTTCTATAATTT
TATAGTTGATTGATTTTTAAAAAGACAAGAGGGTTGCCTAAGTTGGGTGGACTATAGTACAAGTATGGTTCTTGCACTTTTAAAACTGTA
GAAGCTGGACACGATGGTATGCACCTGTAGTCCCAGCTACTTTGACTGTGGAGGCAGGAGGATCACTTGACAGTTTGAGACCAGCCTGGG
CAATGTAGTGAGCCCCCCAAAACCCTCTAAACAAACAAACAAATCTGCAGAATATTTCAGCATCACTCTACACTTTCCTAGAATATCAAC
ATACCTGATAATGAAGTAGAAAGAGTTCCAAATTGATGATTGAGTGTTGGGTTCTAGTTCTATTTCTGCCACTAATTAGTTCTCTGAACT
TAAGTGTTTCATGTCATATTGAAACTTTCTCATTTGTAAAATGTGGAGGGGATCTCTTAAGTGCTTTCTAGTTTCAAAGTACTTTGATAC
TGTGACTTTATTTTGTAGAGGTTCTGGTGTCATTTATTTTTAATAGCTACATGAATAATGTAGAGATACTATCTTTTGATTTCAACTTCA
CATACATGGAAATGAAAGTCTTGTTATTTAACACAAAAGGAAATTTAATTTGCATTATTTAATGCAGTTAATATTACCTAAAATGTTGAA

>85531_85531_10_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000345662_MEMO1_chr2_32168452_ENST00000295065_length(amino acids)=472AA_BP=195
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
MMTNLVMAKDRLQLLGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDI
YRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFV
VSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQ

--------------------------------------------------------------
>85531_85531_11_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000345662_MEMO1_chr2_32168452_ENST00000379383_length(transcript)=2178nt_BP=807nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGCAGGACAGAAGGAGCAAGCTGTGGAATGGTATAAGAAAGGTATTGAAGAACTGGAAAAAGGAATAGCTGTTATAGTTACAGGAC
AAGGTGAACAGTGTGAAAGAGCTAGACGCCTTCAAGCTAAAATGATGACTAATTTGGTTATGGCCAAGGACCGCTTACAACTTCTAGGAC
CGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGAT
ATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATC
ATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAG
AACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTA
AAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAAC
TCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACT
ATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTT
TTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGA
ATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAGCTG
GAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTTTAC
CACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTCCTT
AATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAATGT
AAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTGCAC
ATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATAAAT
GATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAATAAA

>85531_85531_11_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000345662_MEMO1_chr2_32168452_ENST00000379383_length(amino acids)=472AA_BP=195
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
MMTNLVMAKDRLQLLGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDI
YRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFV
VSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQ

--------------------------------------------------------------
>85531_85531_12_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000345662_MEMO1_chr2_32168452_ENST00000404530_length(transcript)=2178nt_BP=807nt
GGCCCGAGCCACCGACTGCAGGAGGAGAAGGGGTTGTGCTCCTGGCCGAGGAAGGAGAAAGGGGCGGGGCCGGCGGGCAGCGTGCGGCAG
TGCGGAGCTCCTGAGACCGGCGGGCACACGGGGGTCTGTGGCCCCCGCCGTAGCAGTGGCTGCCGCCGTCGCTTGGTTCCCGTCGGTCTG
CGGGAGGCGGGTTATGGCGGCGGCGGCAGTGAGAGCTGTGAATGAATTCTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCGCCA
GCAACCCGGTGCCTCCCAGGCCTCCGCCCCCTTGCCTGGCCCCCGCCCCTCCCGCCGCCGGGCCGGCCCCTCCGCCCGAGTCGCCGCATA
AGCGGAACCTGTACTATTTCTCCTACCCGCTGTTTGTAGGCTTCGCGCTGCTGCGTTTGGTCGCCTTCCACCTGGGGCTCCTCTTCGTGT
GGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCAGCCAAGAGGAGCTCCGGGGCCGCGCCAGCACCTGCCTCGGCCTCGGCCCCGGCGC
CGGTGCCGGGCGGCGAGGCCGAGCGCGTCCGAGTCTTCCACAAACAGGCCTTCGAGTACATCTCCATTGCCCTGCGCATCGATGAGGATG
AGAAAGCAGGACAGAAGGAGCAAGCTGTGGAATGGTATAAGAAAGGTATTGAAGAACTGGAAAAAGGAATAGCTGTTATAGTTACAGGAC
AAGGTGAACAGTGTGAAAGAGCTAGACGCCTTCAAGCTAAAATGATGACTAATTTGGTTATGGCCAAGGACCGCTTACAACTTCTAGGAC
CGCAGCTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATTGCCCCCCATGCAGGAT
ATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATC
ATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAG
AACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTA
AAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTGAGTGAGTCAAAAGAACAGGAATTCGGAAAAC
TCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTTGTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACT
ATGATGAATCCCAGGGGGAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTATCTT
TTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTAAATGCTATCACAGAGCTCCAGAAGA
ATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCGAGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAGCTG
GAGCACTCACGGTCCACTGAAGCTCTGAATCCTCAGGGATGCCACCTGCACATTCTCATACTCTGTCCGGGGTCCCAGCCTAGCCTTTAC
CACGATACTGGTCCTGGTTTGGGGGGATTCTGAAACCTCAAACTAATAGAACTTTCTTCTCTTTTTTTCTAGTAGGTGTAGTCCTTCCTT
AATTTCAACTCATTAAAAAATGCTTTATAGTTTAGGGCAGTGGAAGGAAGGCTGGCATCAAAATATTTTGATCAAAAAAGATGACAATGT
AAAGGCTCAGTTGTGGCAGACAGTTTTTTGAAAGTAACTTGTAAAGCATTTACCATATCCTAAATTTGCACTCTTTGCAGACTTGTGCAC
ATATATTCCGCTTTCAGAATAGTTTTGCAAATTGTACACAAACAAACAAAAAGGTGGAAGCTTTTTAATAAAGAAATTGCATTTATAAAT
GATCTGTATTAGAATATAATAAATCTCCAGTTATAGTCAATTACTACCCATGTTGTACAACAGATACCTTCTATTTTAGTTGCTAATAAA

>85531_85531_12_SPAST-MEMO1_SPAST_chr2_32314674_ENST00000345662_MEMO1_chr2_32168452_ENST00000404530_length(amino acids)=472AA_BP=195
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLGLLFVWLCQRFSRALMAAK
RSSGAAPAPASASAPAPVPGGEAERVRVFHKQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
MMTNLVMAKDRLQLLGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDI
YRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFV
VSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPAST-MEMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPAST-MEMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPAST-MEMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource