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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:AXIN1-DNMT3A (FusionGDB2 ID:8555) |
Fusion Gene Summary for AXIN1-DNMT3A |
Fusion gene summary |
Fusion gene information | Fusion gene name: AXIN1-DNMT3A | Fusion gene ID: 8555 | Hgene | Tgene | Gene symbol | AXIN1 | DNMT3A | Gene ID | 8312 | 1788 |
Gene name | axin 1 | DNA methyltransferase 3 alpha | |
Synonyms | AXIN|PPP1R49 | DNMT3A2|HESJAS|M.HsaIIIA|TBRS | |
Cytomap | 16p13.3 | 2p23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | axin-1axis inhibition protein 1axis inhibitor 1fused, mouse, homolog ofprotein phosphatase 1, regulatory subunit 49 | DNA (cytosine-5)-methyltransferase 3ADNA (cytosine-5-)-methyltransferase 3 alphaDNA MTase HsaIIIADNA cytosine methyltransferase 3A2 | |
Modification date | 20200322 | 20200322 | |
UniProtAcc | O15169 | Q9Y6K1 | |
Ensembl transtripts involved in fusion gene | ENST00000262320, ENST00000354866, ENST00000481769, | ENST00000380746, ENST00000402667, ENST00000474887, ENST00000264709, ENST00000321117, ENST00000406659, | |
Fusion gene scores | * DoF score | 16 X 10 X 9=1440 | 4 X 4 X 3=48 |
# samples | 23 | 4 | |
** MAII score | log2(23/1440*10)=-2.6463630453853 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AXIN1 [Title/Abstract] AND DNMT3A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AXIN1(354303)-DNMT3A(25523112), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AXIN1 | GO:0001934 | positive regulation of protein phosphorylation | 9601641 |
Hgene | AXIN1 | GO:0032147 | activation of protein kinase activity | 9601641 |
Hgene | AXIN1 | GO:0034622 | cellular protein-containing complex assembly | 16601693 |
Hgene | AXIN1 | GO:0045732 | positive regulation of protein catabolic process | 9601641 |
Hgene | AXIN1 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 10644691 |
Tgene | DNMT3A | GO:0006306 | DNA methylation | 12138111|19786833|23042785 |
Fusion gene breakpoints across AXIN1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across DNMT3A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8686 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
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Fusion Gene ORF analysis for AXIN1-DNMT3A |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000262320 | ENST00000380746 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5CDS-intron | ENST00000262320 | ENST00000402667 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5CDS-intron | ENST00000262320 | ENST00000474887 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5CDS-intron | ENST00000354866 | ENST00000380746 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5CDS-intron | ENST00000354866 | ENST00000402667 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5CDS-intron | ENST00000354866 | ENST00000474887 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5UTR-3CDS | ENST00000481769 | ENST00000264709 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5UTR-3CDS | ENST00000481769 | ENST00000321117 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5UTR-3CDS | ENST00000481769 | ENST00000406659 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5UTR-intron | ENST00000481769 | ENST00000380746 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5UTR-intron | ENST00000481769 | ENST00000402667 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
5UTR-intron | ENST00000481769 | ENST00000474887 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
In-frame | ENST00000262320 | ENST00000264709 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
In-frame | ENST00000262320 | ENST00000321117 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
In-frame | ENST00000262320 | ENST00000406659 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
In-frame | ENST00000354866 | ENST00000264709 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
In-frame | ENST00000354866 | ENST00000321117 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
In-frame | ENST00000354866 | ENST00000406659 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000262320 | AXIN1 | chr16 | 354303 | - | ENST00000321117 | DNMT3A | chr2 | 25523112 | - | 5596 | 1626 | 21 | 4292 | 1423 |
ENST00000262320 | AXIN1 | chr16 | 354303 | - | ENST00000264709 | DNMT3A | chr2 | 25523112 | - | 5596 | 1626 | 21 | 4292 | 1423 |
ENST00000262320 | AXIN1 | chr16 | 354303 | - | ENST00000406659 | DNMT3A | chr2 | 25523112 | - | 2991 | 1626 | 21 | 2054 | 677 |
ENST00000354866 | AXIN1 | chr16 | 354303 | - | ENST00000321117 | DNMT3A | chr2 | 25523112 | - | 5386 | 1416 | 15 | 4082 | 1355 |
ENST00000354866 | AXIN1 | chr16 | 354303 | - | ENST00000264709 | DNMT3A | chr2 | 25523112 | - | 5386 | 1416 | 15 | 4082 | 1355 |
ENST00000354866 | AXIN1 | chr16 | 354303 | - | ENST00000406659 | DNMT3A | chr2 | 25523112 | - | 2781 | 1416 | 15 | 1844 | 609 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000262320 | ENST00000321117 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - | 0.000880562 | 0.99911946 |
ENST00000262320 | ENST00000264709 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - | 0.000880562 | 0.99911946 |
ENST00000262320 | ENST00000406659 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - | 0.008465235 | 0.99153477 |
ENST00000354866 | ENST00000321117 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - | 0.000631129 | 0.99936885 |
ENST00000354866 | ENST00000264709 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - | 0.000631129 | 0.99936885 |
ENST00000354866 | ENST00000406659 | AXIN1 | chr16 | 354303 | - | DNMT3A | chr2 | 25523112 | - | 0.006864031 | 0.9931359 |
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Fusion Genomic Features for AXIN1-DNMT3A |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AXIN1-DNMT3A |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:354303/chr2:25523112) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
AXIN1 | DNMT3A |
FUNCTION: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453}. | FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 88_211 | 418 | 863.0 | Domain | RGS |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 88_211 | 418 | 827.0 | Domain | RGS |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 20_29 | 418 | 863.0 | Motif | Note=Tankyrase-binding motif |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 20_29 | 418 | 827.0 | Motif | Note=Tankyrase-binding motif |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 292_350 | 24 | 913.0 | Domain | PWWP | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 482_614 | 24 | 913.0 | Domain | ADD | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 634_912 | 24 | 913.0 | Domain | SAM-dependent MTase C5-type | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 292_350 | 24 | 913.0 | Domain | PWWP | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 482_614 | 24 | 913.0 | Domain | ADD | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 634_912 | 24 | 913.0 | Domain | SAM-dependent MTase C5-type | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 292_350 | 0 | 724.0 | Domain | PWWP | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 482_614 | 0 | 724.0 | Domain | ADD | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 634_912 | 0 | 724.0 | Domain | SAM-dependent MTase C5-type | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 292_350 | 0 | 690.0 | Domain | PWWP | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 482_614 | 0 | 690.0 | Domain | ADD | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 634_912 | 0 | 690.0 | Domain | SAM-dependent MTase C5-type | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 292_350 | 24 | 167.0 | Domain | PWWP | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 482_614 | 24 | 167.0 | Domain | ADD | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 634_912 | 24 | 167.0 | Domain | SAM-dependent MTase C5-type | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 641_645 | 24 | 913.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 686_688 | 24 | 913.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 891_893 | 24 | 913.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 641_645 | 24 | 913.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 686_688 | 24 | 913.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 891_893 | 24 | 913.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 641_645 | 0 | 724.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 686_688 | 0 | 724.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 891_893 | 0 | 724.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 641_645 | 0 | 690.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 686_688 | 0 | 690.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 891_893 | 0 | 690.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 641_645 | 24 | 167.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 686_688 | 24 | 167.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 891_893 | 24 | 167.0 | Region | S-adenosyl-L-methionine binding | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 493_523 | 24 | 913.0 | Zinc finger | GATA-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 534_590 | 24 | 913.0 | Zinc finger | PHD-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 493_523 | 24 | 913.0 | Zinc finger | GATA-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 534_590 | 24 | 913.0 | Zinc finger | PHD-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 493_523 | 0 | 724.0 | Zinc finger | GATA-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 534_590 | 0 | 724.0 | Zinc finger | PHD-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 493_523 | 0 | 690.0 | Zinc finger | GATA-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 534_590 | 0 | 690.0 | Zinc finger | PHD-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 493_523 | 24 | 167.0 | Zinc finger | GATA-type%3B atypical | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 534_590 | 24 | 167.0 | Zinc finger | PHD-type%3B atypical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 780_862 | 418 | 863.0 | Domain | DIX |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 780_862 | 418 | 827.0 | Domain | DIX |
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Fusion Gene Sequence for AXIN1-DNMT3A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>8555_8555_1_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000264709_length(transcript)=5596nt_BP=1626nt CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG CGCATGGACGGAGAGGAGCAGGAGGAGCCGCGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGG AGGAAGCGCAAGCACCCCCCGGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCA GGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGC GGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGC CGAGGAGCCCCTGCAGAAGCGGGCAAAGAACAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGT GGCTTGGGCTGGGAGTCCAGCCTCCGTCAGCGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAG CGGGACGAGTGGCTGGCACGCTGGAAAAGGGAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGG CCCGGGGAGTCTCAGAAGGTGGAGGAGGCCAGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCT GAGCCCGTGGGGTCCGATGCTGGGGACAAGAATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATT GGGGAGCTGGTGTGGGGGAAACTGCGGGGCTTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCT GAAGGCACCCGCTGGGTCATGTGGTTCGGAGACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGT GCGTTCCACCAGGCCACGTACAACAAGCAGCCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAG CTGTTCCCGGTGTGCCACGACAGCGATGAGAGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGG GGCTTCCAGCCTTCTGGCCCTAAGGGCCTGGAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAA CCTGAGGCAGCTGCCTACGCACCACCTCCACCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGAT GAGCGCACAAGAGAGCGGCTGGTGTACGAGGTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTT ACCCTGGAACACCCCCTCTTCGTTGGAGGAATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGC TACCAGTCCTACTGCACCATCTGCTGTGGGGGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGT GTGGACCTCTTGGTGGGGCCGGGGGCTGCCCAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTAC GGGCTGCTGCGGCGGCGAGAGGACTGGCCCTCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTT TACCCACCTGTCCCAGCTGAGAAGAGGAAGCCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGAC TTGGGCATTCAGGTGGACCGCTACATTGCCTCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATG TACGTCGGGGACGTCCGCAGCGTCACACAGAAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGAC CTCTCCATCGTCAACCCTGCTCGCAAGGGCCTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGG CCCAAGGAGGGAGATGATCGCCCCTTCTTCTGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTT CTCGAGTCCAACCCTGTGATGATTGATGCCAAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAAC AGGCCGTTGGCATCCACTGTGAATGATAAGCTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACC ATTACTACGAGGTCAAACTCCATAAAGCAGGGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACT GAAATGGAAAGGGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCA TGGAGCGTGCCAGTCATCCGCCACCTCTTCGCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCG ACACAAAGTTAAACAAACAAACAAAAAACACAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAG AAAAAGGAATTTAAAACAAAAACCACAGAGGCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTC AATGTTATTCTTCAGTCCTATTTAAAAACAAAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTT CTACTCTTTTCAGAGGGGTTTTCTGTTTGTTTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAAC AAAAAATAGTAACAATACCTTGCAGAGGAAAGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTT TTTGTTTTTTGTTTTTTTTTTTTGGGTTTTTTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCA GGGGACGGAAAGAGAGAGACACTCAGGCGGCAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACA GAACCCAGTTAGCAGCAGGGAGACGAGAACACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGA AAATCAGTTTCTAGAAGCCGCTGTTACCTCTTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAA CTACTGTACAACCCGACTTCATAATGGTGCTTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTT TCACCAAGGATGGAGAAAGGGAGACAGCTTGCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGA GAACTTGGGAGCCAGGTTCTCCCTGCCAAAAAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACT CATGCAATAACCCTTTGATTGTTTTCTAAAAGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTT TAGCCAATTCGAGGGCTCCTTGTGGTGGGATCAGAACTAATCCAGAGTGTGGGAAAGTGACAGTCAAAACCCCACCTGGAGCAAATAAAA >8555_8555_1_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000264709_length(amino acids)=1423AA_BP=535 MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE GAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLAR WKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGK LRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHD SDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERL VYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGP GAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDR YIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDR PFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNS -------------------------------------------------------------- >8555_8555_2_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000321117_length(transcript)=5596nt_BP=1626nt CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG CGCATGGACGGAGAGGAGCAGGAGGAGCCGCGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGG AGGAAGCGCAAGCACCCCCCGGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCA GGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGC GGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGC CGAGGAGCCCCTGCAGAAGCGGGCAAAGAACAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGT GGCTTGGGCTGGGAGTCCAGCCTCCGTCAGCGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAG CGGGACGAGTGGCTGGCACGCTGGAAAAGGGAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGG CCCGGGGAGTCTCAGAAGGTGGAGGAGGCCAGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCT GAGCCCGTGGGGTCCGATGCTGGGGACAAGAATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATT GGGGAGCTGGTGTGGGGGAAACTGCGGGGCTTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCT GAAGGCACCCGCTGGGTCATGTGGTTCGGAGACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGT GCGTTCCACCAGGCCACGTACAACAAGCAGCCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAG CTGTTCCCGGTGTGCCACGACAGCGATGAGAGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGG GGCTTCCAGCCTTCTGGCCCTAAGGGCCTGGAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAA CCTGAGGCAGCTGCCTACGCACCACCTCCACCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGAT GAGCGCACAAGAGAGCGGCTGGTGTACGAGGTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTT ACCCTGGAACACCCCCTCTTCGTTGGAGGAATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGC TACCAGTCCTACTGCACCATCTGCTGTGGGGGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGT GTGGACCTCTTGGTGGGGCCGGGGGCTGCCCAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTAC GGGCTGCTGCGGCGGCGAGAGGACTGGCCCTCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTT TACCCACCTGTCCCAGCTGAGAAGAGGAAGCCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGAC TTGGGCATTCAGGTGGACCGCTACATTGCCTCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATG TACGTCGGGGACGTCCGCAGCGTCACACAGAAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGAC CTCTCCATCGTCAACCCTGCTCGCAAGGGCCTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGG CCCAAGGAGGGAGATGATCGCCCCTTCTTCTGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTT CTCGAGTCCAACCCTGTGATGATTGATGCCAAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAAC AGGCCGTTGGCATCCACTGTGAATGATAAGCTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACC ATTACTACGAGGTCAAACTCCATAAAGCAGGGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACT GAAATGGAAAGGGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCA TGGAGCGTGCCAGTCATCCGCCACCTCTTCGCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCG ACACAAAGTTAAACAAACAAACAAAAAACACAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAG AAAAAGGAATTTAAAACAAAAACCACAGAGGCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTC AATGTTATTCTTCAGTCCTATTTAAAAACAAAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTT CTACTCTTTTCAGAGGGGTTTTCTGTTTGTTTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAAC AAAAAATAGTAACAATACCTTGCAGAGGAAAGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTT TTTGTTTTTTGTTTTTTTTTTTTGGGTTTTTTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCA GGGGACGGAAAGAGAGAGACACTCAGGCGGCAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACA GAACCCAGTTAGCAGCAGGGAGACGAGAACACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGA AAATCAGTTTCTAGAAGCCGCTGTTACCTCTTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAA CTACTGTACAACCCGACTTCATAATGGTGCTTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTT TCACCAAGGATGGAGAAAGGGAGACAGCTTGCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGA GAACTTGGGAGCCAGGTTCTCCCTGCCAAAAAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACT CATGCAATAACCCTTTGATTGTTTTCTAAAAGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTT TAGCCAATTCGAGGGCTCCTTGTGGTGGGATCAGAACTAATCCAGAGTGTGGGAAAGTGACAGTCAAAACCCCACCTGGAGCAAATAAAA >8555_8555_2_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000321117_length(amino acids)=1423AA_BP=535 MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE GAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLAR WKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGK LRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHD SDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERL VYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGP GAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDR YIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDR PFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNS -------------------------------------------------------------- >8555_8555_3_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000406659_length(transcript)=2991nt_BP=1626nt CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG CGCATGGACGGAGAGGAGCAGGAGGAGCCGCGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGG AGGAAGCGCAAGCACCCCCCGGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCA GGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGC GGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGC CGAGGAGCCCCTGCAGAAGCGGGTGAGTCCTCAGCACCAGGGGCAGCCTCTTCTGGGCCCACCAGCATACCCTGAGAGTCAGGGACTTGG CTCTCCAGCAGGTCCCAGGAAGGATGGTCTGGGTCGTGGCTAAAGGTCTGCTTGCCAAGGCTATGGCCTGGAGGCTACTGGCTGGATGCA GCCTGCGCATATGTTTTATTTGGCCCATAGAGTGTTTTAAACATTTAAAAAATTAGTTGCCAGTATTTAAAAATCAAAAAATTTCACATA AAAATCTGGAGTTTTGGCTTCTCATGAAAAAAAAAAAAGCTAGATCTGGCAACAGCGGGCTTTCATAACGCCAACGATTGCTAGACTGGG ATAATGGCGGTCCCTCCATCGCCTTCTGTGGCTGGTTGTGGGCCTTAGTTTTCTGCAGCTCTACCTGGCCTGCTTACTCTCCCACGTGCC ATGCAGTTCCTGGGGGTTGCTGTATTTGTAGCCCCTGGCCTGGGCACTCAAGGGCAGCAGATACCCTGTTTGCCTCCCTGAGTGCAGAGG TCCTGAGCCCACCCTAGTTGGGCTGACTCAACTGGAAATTTGGTTGTGACAGTGGCGTGGGGAGAGGGCTGGGTGATTGTATTCTGTGTA CTGCCCAGCCCAGGCCTCTTCATCTGGGGACTTTTTGGCCTAACCCTGGAAGCCTGGAAAGTTGCCCACTTTTCTCTTTCAGGTTAAGCC AGCAATTTCAGGGCCAACCGAGCTGTAAACATGTTAGTAATGAGGACAACTAGCATTTGTACAGGGCTTCACAGTTTACAAAGCGCTTTC TCATACATTATCACATTTGATCCTCCCAGGGCCCTGCCAGGTTGTTTTGCATATGTGCATTTTAATTTCAAAAAGTCTTCCTTCCAAGCG TGTATGATGAAATGAGTAAATTGATTAATTGGCGTAACTTATTTTGCATGGATCCAACCTAATGTTCATGCAGGATAGAGAACATTTCCA >8555_8555_3_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000406659_length(amino acids)=677AA_BP=535 MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE -------------------------------------------------------------- >8555_8555_4_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000264709_length(transcript)=5386nt_BP=1416nt GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGACGGAGAGGAGCAGGAGGAGCCG CGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGGAGGAAGCGCAAGCACCCCCCGGTGGAAAGC GGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGAC TTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCT GAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGCAAAGAA CAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGTGGCTTGGGCTGGGAGTCCAGCCTCCGTCAG CGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAGCGGGACGAGTGGCTGGCACGCTGGAAAAGG GAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGGCCCGGGGAGTCTCAGAAGGTGGAGGAGGCC AGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCTGAGCCCGTGGGGTCCGATGCTGGGGACAAG AATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATTGGGGAGCTGGTGTGGGGGAAACTGCGGGGC TTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCTGAAGGCACCCGCTGGGTCATGTGGTTCGGA GACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGTGCGTTCCACCAGGCCACGTACAACAAGCAG CCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAGCTGTTCCCGGTGTGCCACGACAGCGATGAG AGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGGGGCTTCCAGCCTTCTGGCCCTAAGGGCCTG GAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAACCTGAGGCAGCTGCCTACGCACCACCTCCA CCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGATGAGCGCACAAGAGAGCGGCTGGTGTACGAG GTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTTACCCTGGAACACCCCCTCTTCGTTGGAGGA ATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGCTACCAGTCCTACTGCACCATCTGCTGTGGG GGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGTGTGGACCTCTTGGTGGGGCCGGGGGCTGCC CAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTACGGGCTGCTGCGGCGGCGAGAGGACTGGCCC TCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTTTACCCACCTGTCCCAGCTGAGAAGAGGAAG CCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGACTTGGGCATTCAGGTGGACCGCTACATTGCC TCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATGTACGTCGGGGACGTCCGCAGCGTCACACAG AAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGACCTCTCCATCGTCAACCCTGCTCGCAAGGGC CTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGGCCCAAGGAGGGAGATGATCGCCCCTTCTTC TGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTTCTCGAGTCCAACCCTGTGATGATTGATGCC AAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAACAGGCCGTTGGCATCCACTGTGAATGATAAG CTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACCATTACTACGAGGTCAAACTCCATAAAGCAG GGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACTGAAATGGAAAGGGTATTTGGTTTCCCAGTC CACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCATGGAGCGTGCCAGTCATCCGCCACCTCTTC GCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCGACACAAAGTTAAACAAACAAACAAAAAACA CAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAGAAAAAGGAATTTAAAACAAAAACCACAGAG GCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTCAATGTTATTCTTCAGTCCTATTTAAAAACA AAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTTCTACTCTTTTCAGAGGGGTTTTCTGTTTGT TTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAACAAAAAATAGTAACAATACCTTGCAGAGGAA AGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTTTTTGTTTTTTGTTTTTTTTTTTTGGGTTTT TTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCAGGGGACGGAAAGAGAGAGACACTCAGGCGG CAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACAGAACCCAGTTAGCAGCAGGGAGACGAGAAC ACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGAAAATCAGTTTCTAGAAGCCGCTGTTACCTC TTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAACTACTGTACAACCCGACTTCATAATGGTGC TTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTTTCACCAAGGATGGAGAAAGGGAGACAGCTT GCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGAGAACTTGGGAGCCAGGTTCTCCCTGCCAAA AAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACTCATGCAATAACCCTTTGATTGTTTTCTAAA AGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTTTAGCCAATTCGAGGGCTCCTTGTGGTGGGA >8555_8555_4_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000264709_length(amino acids)=1355AA_BP=467 MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS EPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPR LTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKA GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRK AIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKP RKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVL MCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVL SLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQE CLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKE -------------------------------------------------------------- >8555_8555_5_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000321117_length(transcript)=5386nt_BP=1416nt GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGACGGAGAGGAGCAGGAGGAGCCG CGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGGAGGAAGCGCAAGCACCCCCCGGTGGAAAGC GGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGAC TTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCT GAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGCAAAGAA CAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGTGGCTTGGGCTGGGAGTCCAGCCTCCGTCAG CGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAGCGGGACGAGTGGCTGGCACGCTGGAAAAGG GAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGGCCCGGGGAGTCTCAGAAGGTGGAGGAGGCC AGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCTGAGCCCGTGGGGTCCGATGCTGGGGACAAG AATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATTGGGGAGCTGGTGTGGGGGAAACTGCGGGGC TTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCTGAAGGCACCCGCTGGGTCATGTGGTTCGGA GACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGTGCGTTCCACCAGGCCACGTACAACAAGCAG CCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAGCTGTTCCCGGTGTGCCACGACAGCGATGAG AGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGGGGCTTCCAGCCTTCTGGCCCTAAGGGCCTG GAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAACCTGAGGCAGCTGCCTACGCACCACCTCCA CCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGATGAGCGCACAAGAGAGCGGCTGGTGTACGAG GTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTTACCCTGGAACACCCCCTCTTCGTTGGAGGA ATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGCTACCAGTCCTACTGCACCATCTGCTGTGGG GGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGTGTGGACCTCTTGGTGGGGCCGGGGGCTGCC CAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTACGGGCTGCTGCGGCGGCGAGAGGACTGGCCC TCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTTTACCCACCTGTCCCAGCTGAGAAGAGGAAG CCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGACTTGGGCATTCAGGTGGACCGCTACATTGCC TCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATGTACGTCGGGGACGTCCGCAGCGTCACACAG AAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGACCTCTCCATCGTCAACCCTGCTCGCAAGGGC CTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGGCCCAAGGAGGGAGATGATCGCCCCTTCTTC TGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTTCTCGAGTCCAACCCTGTGATGATTGATGCC AAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAACAGGCCGTTGGCATCCACTGTGAATGATAAG CTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACCATTACTACGAGGTCAAACTCCATAAAGCAG GGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACTGAAATGGAAAGGGTATTTGGTTTCCCAGTC CACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCATGGAGCGTGCCAGTCATCCGCCACCTCTTC GCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCGACACAAAGTTAAACAAACAAACAAAAAACA CAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAGAAAAAGGAATTTAAAACAAAAACCACAGAG GCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTCAATGTTATTCTTCAGTCCTATTTAAAAACA AAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTTCTACTCTTTTCAGAGGGGTTTTCTGTTTGT TTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAACAAAAAATAGTAACAATACCTTGCAGAGGAA AGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTTTTTGTTTTTTGTTTTTTTTTTTTGGGTTTT TTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCAGGGGACGGAAAGAGAGAGACACTCAGGCGG CAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACAGAACCCAGTTAGCAGCAGGGAGACGAGAAC ACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGAAAATCAGTTTCTAGAAGCCGCTGTTACCTC TTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAACTACTGTACAACCCGACTTCATAATGGTGC TTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTTTCACCAAGGATGGAGAAAGGGAGACAGCTT GCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGAGAACTTGGGAGCCAGGTTCTCCCTGCCAAA AAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACTCATGCAATAACCCTTTGATTGTTTTCTAAA AGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTTTAGCCAATTCGAGGGCTCCTTGTGGTGGGA >8555_8555_5_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000321117_length(amino acids)=1355AA_BP=467 MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS EPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPR LTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKA GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRK AIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKP RKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVL MCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVL SLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQE CLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKE -------------------------------------------------------------- >8555_8555_6_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000406659_length(transcript)=2781nt_BP=1416nt GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGACGGAGAGGAGCAGGAGGAGCCG CGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGGAGGAAGCGCAAGCACCCCCCGGTGGAAAGC GGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGAC TTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCT GAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGTGAGTCC TCAGCACCAGGGGCAGCCTCTTCTGGGCCCACCAGCATACCCTGAGAGTCAGGGACTTGGCTCTCCAGCAGGTCCCAGGAAGGATGGTCT GGGTCGTGGCTAAAGGTCTGCTTGCCAAGGCTATGGCCTGGAGGCTACTGGCTGGATGCAGCCTGCGCATATGTTTTATTTGGCCCATAG AGTGTTTTAAACATTTAAAAAATTAGTTGCCAGTATTTAAAAATCAAAAAATTTCACATAAAAATCTGGAGTTTTGGCTTCTCATGAAAA AAAAAAAAGCTAGATCTGGCAACAGCGGGCTTTCATAACGCCAACGATTGCTAGACTGGGATAATGGCGGTCCCTCCATCGCCTTCTGTG GCTGGTTGTGGGCCTTAGTTTTCTGCAGCTCTACCTGGCCTGCTTACTCTCCCACGTGCCATGCAGTTCCTGGGGGTTGCTGTATTTGTA GCCCCTGGCCTGGGCACTCAAGGGCAGCAGATACCCTGTTTGCCTCCCTGAGTGCAGAGGTCCTGAGCCCACCCTAGTTGGGCTGACTCA ACTGGAAATTTGGTTGTGACAGTGGCGTGGGGAGAGGGCTGGGTGATTGTATTCTGTGTACTGCCCAGCCCAGGCCTCTTCATCTGGGGA CTTTTTGGCCTAACCCTGGAAGCCTGGAAAGTTGCCCACTTTTCTCTTTCAGGTTAAGCCAGCAATTTCAGGGCCAACCGAGCTGTAAAC ATGTTAGTAATGAGGACAACTAGCATTTGTACAGGGCTTCACAGTTTACAAAGCGCTTTCTCATACATTATCACATTTGATCCTCCCAGG GCCCTGCCAGGTTGTTTTGCATATGTGCATTTTAATTTCAAAAAGTCTTCCTTCCAAGCGTGTATGATGAAATGAGTAAATTGATTAATT >8555_8555_6_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000406659_length(amino acids)=609AA_BP=467 MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AXIN1-DNMT3A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 209_338 | 418.0 | 863.0 | TP53 |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 209_338 | 418.0 | 827.0 | TP53 |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 199_403 | 24.0 | 913.0 | DNMT1 and DNMT3B | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 199_403 | 24.0 | 913.0 | DNMT1 and DNMT3B | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 199_403 | 0 | 724.0 | DNMT1 and DNMT3B | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 199_403 | 0 | 690.0 | DNMT1 and DNMT3B | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 199_403 | 24.0 | 167.0 | DNMT1 and DNMT3B | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000264709 | 1 | 23 | 494_586 | 24.0 | 913.0 | the PRC2/EED-EZH2 complex | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000321117 | 1 | 23 | 494_586 | 24.0 | 913.0 | the PRC2/EED-EZH2 complex | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000380746 | 0 | 19 | 494_586 | 0 | 724.0 | the PRC2/EED-EZH2 complex | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000402667 | 0 | 18 | 494_586 | 0 | 690.0 | the PRC2/EED-EZH2 complex | |
Tgene | DNMT3A | chr16:354303 | chr2:25523112 | ENST00000406659 | 1 | 4 | 494_586 | 24.0 | 167.0 | the PRC2/EED-EZH2 complex |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 434_502 | 418.0 | 863.0 | CTNNB1 |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 434_502 | 418.0 | 827.0 | CTNNB1 |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 348_433 | 418.0 | 863.0 | GSK3B |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 348_433 | 418.0 | 827.0 | GSK3B |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 677_752 | 418.0 | 863.0 | HIPK2 |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 677_752 | 418.0 | 827.0 | HIPK2 |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 575_789 | 418.0 | 863.0 | PPP2CA |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 575_789 | 418.0 | 827.0 | PPP2CA |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000262320 | - | 5 | 11 | 507_757 | 418.0 | 863.0 | RNF111 |
Hgene | AXIN1 | chr16:354303 | chr2:25523112 | ENST00000354866 | - | 5 | 10 | 507_757 | 418.0 | 827.0 | RNF111 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AXIN1-DNMT3A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AXIN1-DNMT3A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |