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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SPATA6L-GLIS3 (FusionGDB2 ID:85579)

Fusion Gene Summary for SPATA6L-GLIS3

Fusion gene summary

Fusion gene information	Fusion gene name: SPATA6L-GLIS3
	Fusion gene ID: 85579
		Hgene	Tgene
	Gene symbol	SPATA6L	GLIS3
	Gene ID	55064	169792
	Gene name	spermatogenesis associated 6 like	GLIS family zinc finger 3
	Synonyms	C9orf68\|bA6J24.2	NDH\|ZNF515
	Cytomap	9p24.2-p24.1	9p24.2
	Type of gene	protein-coding	protein-coding
	Description	spermatogenesis associated 6-like protein	zinc finger protein GLIS3GLI-similar 3OK/KNS-cl.4zinc finger protein 515
	Modification date	20200313	20200313
	UniProtAcc	.	Q8NEA6
	Ensembl transtripts involved in fusion gene	ENST00000381890, ENST00000454239, ENST00000475086, ENST00000223517, ENST00000381895,	ENST00000461870, ENST00000324333, ENST00000381971,
Fusion gene scores	* DoF score	2 X 2 X 2=8	10 X 7 X 7=490
	# samples	2	10
	** MAII score	log2(2/8*10)=1.32192809488736	log2(10/490*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SPATA6L [Title/Abstract] AND GLIS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SPATA6L(4661899)-GLIS3(3937189), # samples:2
Anticipated loss of major functional domain due to fusion event.	SPATA6L-GLIS3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SPATA6L-GLIS3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SPATA6L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GLIS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-BP-4983-01A	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-

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Fusion Gene ORF analysis for SPATA6L-GLIS3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000381890	ENST00000461870	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5CDS-5UTR	ENST00000454239	ENST00000461870	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5CDS-5UTR	ENST00000475086	ENST00000461870	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5UTR-3CDS	ENST00000223517	ENST00000324333	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5UTR-3CDS	ENST00000223517	ENST00000381971	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5UTR-3CDS	ENST00000381895	ENST00000324333	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5UTR-3CDS	ENST00000381895	ENST00000381971	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5UTR-5UTR	ENST00000223517	ENST00000461870	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
5UTR-5UTR	ENST00000381895	ENST00000461870	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
Frame-shift	ENST00000454239	ENST00000324333	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
Frame-shift	ENST00000454239	ENST00000381971	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
Frame-shift	ENST00000475086	ENST00000324333	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
Frame-shift	ENST00000475086	ENST00000381971	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
In-frame	ENST00000381890	ENST00000324333	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-
In-frame	ENST00000381890	ENST00000381971	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000381890	SPATA6L	chr9	4661899	-	ENST00000381971	GLIS3	chr9	3937189	-	1931	274	34	1356	440
ENST00000381890	SPATA6L	chr9	4661899	-	ENST00000324333	GLIS3	chr9	3937189	-	5502	274	34	1356	440

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000381890	ENST00000381971	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-	0.045285285	0.9547148
ENST00000381890	ENST00000324333	SPATA6L	chr9	4661899	-	GLIS3	chr9	3937189	-	0.002331265	0.9976687

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Fusion Genomic Features for SPATA6L-GLIS3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPATA6L-GLIS3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:4661899/chr9:3937189)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GLIS3 Q8NEA6
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

491_507

415

776.0

Motif

Bipartite nuclear localization signal

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

412_436

415

776.0

Zinc finger

C2H2-type 3

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

442_466

415

776.0

Zinc finger

C2H2-type 4

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

472_496

415

776.0

Zinc finger

C2H2-type 5

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

289_306

415

776.0

Compositional bias

Note=Pro-rich

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

41_154

415

776.0

Compositional bias

Note=Ser-rich

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

289_306

570

931.0

Compositional bias

Note=Pro-rich

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

41_154

570

931.0

Compositional bias

Note=Ser-rich

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

491_507

570

931.0

Motif

Bipartite nuclear localization signal

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

345_370

415

776.0

Zinc finger

C2H2-type 1

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000324333

379_406

415

776.0

Zinc finger

C2H2-type 2%3B atypical

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

345_370

570

931.0

Zinc finger

C2H2-type 1

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

379_406

570

931.0

Zinc finger

C2H2-type 2%3B atypical

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

412_436

570

931.0

Zinc finger

C2H2-type 3

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

442_466

570

931.0

Zinc finger

C2H2-type 4

Tgene

GLIS3

chr9:4661899

chr9:3937189

ENST00000381971

472_496

570

931.0

Zinc finger

C2H2-type 5

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Fusion Gene Sequence for SPATA6L-GLIS3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>85579_85579_1_SPATA6L-GLIS3_SPATA6L_chr9_4661899_ENST00000381890_GLIS3_chr9_3937189_ENST00000324333_length(transcript)=5502nt_BP=274nt
ATTTGCTCTAGGTATTCAGCTAAACTAAGAAAAATTGGTCCAAGGCTCGGCACAAAAGGATCTTCTCATTCCAGTCCTTTCGCCCACGCA
GGGAACGATGCCTCTGGAGGTGGTGGTGGAGCTGCAGATCCGGGCGATTTCTTGCCCAGGAGTGTTCCTGCCTGGCAAACAAGATGTGTA
CCTCGGGGTCTACCTCATGAATCAGTACCTGGAGACCAACAGCTTTCCCTCTGCGTTCCCCATTATGATTCAGGAGAGCATGAGATTTGA
AAAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGAAAATCTCAAGATCCACTTGCGGAGCCACACAGGCGAGAAGCCGTATTTGTG
CCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAGTGACCGCGCCAAACACCAGCGGACGCATCTGGACACCAAACCTTATGCTTG
TCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAGTTCCCTAAGAAAGCATGTGAAGGCACATTCTTCCAAAGAGCAACAAGCAAG
GAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCTGCTCACAGATTGCCTCACCGTGCAGTCCCTGCAGCCGGCCACTTCCCCTAG
AGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGGACCCGGGCCTGACCTCTATTCAGCTCCCATTTTCTCCAGCAATTATTCAAG
CCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACATCCTGTCAGTCACCCTTCTCCAGGACATAATGTACAGGGGAGCCCTCACAA
CCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGCAGGAGCTGAGAGGTTTGCACCTTCTGCTCCATCTCCTCACCACATCAGCCC
CCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAACACAGCCTCCCTATACCCAGCAGCCATCAGGTTCACACCTGAAGTCCTATCA
GCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCATGTCCATGGATTTTATGGGCAGCTGCAGAAGTTCTGTCCCCCACACTACCC
CGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAGTGTGGTGCCTTCGTTTGAGGACTGCCTAGTCCCTACATCCATGGGCCAGGC
CAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTCGGGCATTACAGTGTATGATTTACCTTCAAGTTCCTCGAGCCTCTTTGGGGA
GTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCAGATCAGCACCGTGGACCGCTGTCCTAGCCAGCTCTCCTCTGTCTACACCGA
AGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGACCTTGATGTTGCTTGCCACCTTTTGTTTTCGTACTCTCACAGACTGCTTGA
GGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTACTGATGTTCTTTCAGAAGGCAGGACTGAATGGCAGAGCTAGCTTTGCAGGA
ATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGGACTATGTGACCAGGAGGACTGTCTTTTCAAAGGGAATTTAGAGCCTCACTC
TCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAAGGACCCCAGTGAAATGATGTGCATATGAAAATGTAGTTTGGGGATGACTCT
ACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACGAGAGGCATAGTGACCTGCCTCACCTAATCCTCACCCTTGCTGCTCCTGATG
CAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCATAGTGTGGTCTCAACTCTTAGAAACTCCCTGGGTTTCCCTTTTCTCTTAGC
CACATGCTAACCAGTTGCTTCTCAGTGTTTCTCTTCAATAGAAAAATAAGGTTTTATATGCCAGCAGCCTATCCTTGTTTTTGCATTTTA
AAGACTTAGTTATTTATACGTATTTTAAAATGAAAAAAAAATGTAAAGGTCTGTGCTTTGGATGGAAATCATTATTATTGTAATCACCCC
AGCTATAGACATTTTGCACAGCTGTGGTTCTGCCTGGCCCCACCTCTAGCATGTTAGTTTTGCAGTTAGCAAAGGTTACCTGAGGGAAAT
GGAGTGGGCACCTCCCGCACCAACAGTCCTGTAGCTGGAACCTTCCTGAGTTGACTGTTTAGTAACTCCACCTCAAAGACTGTGTTCAAA
GAAAAATGTTGTTTGACTGGTTTACCCATTGCCTCCACTCTGGTGCTGCACCCAGAGAAGTGCCAGATGTGAGAACTGGGACAGACTGAG
TCATGTGCCAGCTTCCCTTGGAAAACCAAACCTAGTGATACTTGACTTCCAGTGCTCAGATTTTACTAACGTTTTTCAGGATATCCACTC
ATCTGTCTGTCTCTTCCCTACACTTCTCTCCACCCTCTTTTTGCATCCCTCTTACCCTCTTCCTGACTGTGGTTCATATATCCCCACCAG
CCGCCATTGTCTGATCATCTTGGGAAGGTAGAGGTGACAGTTCTCGAAAAGTCTACAGAAAGAGGCAATTCTTTTTCTGAGTTCCAGTTT
GAAGGCCTGGAATTTTCACATAGCACTTGGTCGAAAATATCAAGCCTAAATAGGAAGTCATTTTCTGTGACACCTCTACATAGCTATTAC
AGATCCTAAGTCCTAGGGCATCAGCTATAAAAATTGGCCAGTCCCAAAGACACAGTAAGTTCTAACATTCTGGTACTATCATATTTCAAG
TATTTTTTCTCACTTTTTAAAAATGTTTTTCTGAACAAAAGTGAAACAATGCCATTTATCAAACTGAGATCATTACAATCTTCAACAAGA
CAACTAAAACAGCTTGATGTTAGATGGGATTCTGTGACAGTTTGTATACTGACAGGTCCTTCCAGTCTCCCTCCACAGTCCCACAAGCGG
AAGTATTCTACCTGATTCCAGAGTTCATTCCAACATGCAGTAGAATGAGGTGAATGAAGAACCAAGTGTGGGTTTTGTTTTCACAGTGCA
CTTGGTCAATCTAGTTTCTCTGAGTAGTGGGCTGTATTCTAAGAAAAGCTTTCACGTAGACGTCAAAGTCTGCAAAAGAGATGAGTTAGC
CACTTTAAAAAACCTGCTCTGCTTTACAAAAGATGCACACCAGGCTTCCTTTACAAGTGAACTCCAAGGCTGCTTGTAAAGTACCACCCT
TCCTGCAGACTTTGTGGGTCGTGTCACTTGGCCTAAACAAGTGGCCTAACATATGCATGCTCACAGCTAGTAGCATCCCTCATGCGTCCT
TTGTCATACTCTGGAAAGAAAAAAACTCTGCTATCTTCAGAGAAACCATCTATTCATACTTAAATATGGAAGCCTTTACAAGGAACTCAA
AATACATTTCATTTCATTTGTACAATGAGAAAAAAGATGAAAAGGCAAGGTTGTTATTGCAGTTGACATTGTCAGCCCTGCCTTTTGGCT
TTATGTAATTTAAAATAGAAAGGGGGAAGGAGGACAAGACAGAAGCTCAACTTTAGAAACCATGGACATCACCTCCCTCTTTGAGAGGAG
CTGCTTGTGAACCAGGCTCCAGTCTTCCTGTGGCCTCTCACAGTAACCCTGCCCCTTTCTTACCTCACAGGGGCAAGAGGGACTCTAAAG
AGGGCGTAAGCAATAGAGGCACCTGCAGCCCTCCTTCCTCAGCAGGAAATCAATGTGGAGCCCCAGAGGGACATTTTATCTCAGAGAGAG
CATGCTGGCCACAGGACCCAGTGCAGCCCTGCTTCCCGCACCGTGGGTCTTTCCTGATAGCTGCAGGCTTGAGATTGCAGCCTCAGGATA
GGACACGTTCAGATGCCTTCCAGACTACACACACTATGCTTAGATTCGAGAGTCTTTCCTGACCTTAAAATTTGTCCCTTGCTTACTTTC
ACACTGCAGAAGATTTATATATATATTCATCATTATTTTTGCAGCAGTACAAGTGGAAACTTCAAAAAAATCATTCCCTTTCATGTCCTG
GTCTTTTTAAGTCTTGATATGTAACCATTTTCATAAATGTCCAAACAGAGATTGTCATTCCCCTTAAAAACAGAAACAAAACACAAAACT
AGTGCTTGTGAAAACACACAGCGCAAAGACAATTATCCTATTGCATTAAAAAAAAAATCAGTCTGCCTAGAGACATTTCATTGGCTGCAT
TGTCTTAATTCCCTAACGAAACTGCATCAAAATGTCAGTTGTAATTTAGCCTCTGATCAGCTGTTAAATATTATTTAAATATTTACAGGT
CCTGTGGGGTATCTCCCATTACCCATGTCGCCCTCAAATTACATAAGCGATCATAAAATAAGAAGAAAAAAAAAGGTCTTTAGTAGATCA
CAGCAGAGTTACCACTGATAAGAGTGTTGGCTTTGTTCAGTTGTTTCTAAATTACCAGCCGTCAAGCACAGTAGCCCCTAAAACCAATTT
TGAGCAAGGATAAATTCAACTCCCTCATCTGAGAACCTTGACTTTCCAGTTGCCTTGAAGTATTGGGAATAGTAACTGTACATTTTCAAT
TTAATTATTTGGTATTTTATTTGACTGTCTTGGCCATGTCATTTTATGGAAGCATTTTTAAATAGCACTTTTTGTTAGTGGTGTGGAATT
TCTGCGGTTATTATTTTTTTTTTTTTTTGCAACAGATGAAGCAAAAAAAAAAAAGCACTCATTGGAGAAATAGTGAGTGTAAAAAGAGAT
TTATTTTGTACAGACAGCAAAGTATCCTGTGTAATGTTGCTGACATAAAGCACTTTGGGGGAAAAAAGTGGAAATCTGTTTTCCATAAAT
CACACAGACTCTTGTACATAGTTATATACACTCACGTAGAGAAATGAACTGCATATATCATACTGGATATGGGGCCGATTTTACTCTAGA
GGCACATCTGGTGCTTATTGTCATAAATCTTTTAAAGAATTAGGTACACTTTTTTCTATTAATATGTATAGTTTTGTGATTTGTCACAGT
TATGTTTCATATAATCATAAGTTATTTTGTCTTGTTCATGAAGTCCTTTTTTTATGTCAAAAGTAAAATGAAGGGATTGTGCACTTGGTA
CAGAATAAAACTGGAAATAGAGAAGACGCCCTCCTGCCTAAAATCCTCCTTCAGCCTGTCGGTTTAAAACACAATGGCAACCATCATTGT
TTGTTTGTTTGTTTTTTTGTTTTGTTTTACCATCAGCCTCTTACATACTGGGAATGGTAATTATAATTAAAGGCAGATGATGCGGGAGGG
AATGTTCAAGTCCAGCTTTAAAATGCTGCATTGCTTTGGGCCAGAGCTGTAGCCTGGATTTAATTATAGATATGAGGAGGAAATGGCAGT
AAAAATGAATGTCTCCCTGAGTCCTTTACATGTTGGGAGTGTCCATAAATAAAACATGAAGTTTTATTTCATCAGATTTAATTAAAGCTT

>85579_85579_1_SPATA6L-GLIS3_SPATA6L_chr9_4661899_ENST00000381890_GLIS3_chr9_3937189_ENST00000324333_length(amino acids)=440AA_BP=1
MVQGSAQKDLLIPVLSPTQGTMPLEVVVELQIRAISCPGVFLPGKQDVYLGVYLMNQYLETNSFPSAFPIMIQESMRFEKFEGCEKAFSR
LENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHP
DLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAV
DAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSS

--------------------------------------------------------------
>85579_85579_2_SPATA6L-GLIS3_SPATA6L_chr9_4661899_ENST00000381890_GLIS3_chr9_3937189_ENST00000381971_length(transcript)=1931nt_BP=274nt
ATTTGCTCTAGGTATTCAGCTAAACTAAGAAAAATTGGTCCAAGGCTCGGCACAAAAGGATCTTCTCATTCCAGTCCTTTCGCCCACGCA
GGGAACGATGCCTCTGGAGGTGGTGGTGGAGCTGCAGATCCGGGCGATTTCTTGCCCAGGAGTGTTCCTGCCTGGCAAACAAGATGTGTA
CCTCGGGGTCTACCTCATGAATCAGTACCTGGAGACCAACAGCTTTCCCTCTGCGTTCCCCATTATGATTCAGGAGAGCATGAGATTTGA
AAAGTTTGAAGGTTGCGAGAAGGCCTTTTCAAGGCTTGAAAATCTCAAGATCCACTTGCGGAGCCACACAGGCGAGAAGCCGTATTTGTG
CCAGCATCCGGGTTGTCAGAAGGCCTTCAGTAACTCCAGTGACCGCGCCAAACACCAGCGGACGCATCTGGACACCAAACCTTATGCTTG
TCAAATTCCAGGATGTACCAAACGCTACACAGACCCAAGTTCCCTAAGAAAGCATGTGAAGGCACATTCTTCCAAAGAGCAACAAGCAAG
GAAAAAGTTGCGGTCCAGCACAGAGCTCCATCCAGACCTGCTCACAGATTGCCTCACCGTGCAGTCCCTGCAGCCGGCCACTTCCCCTAG
AGATGCTGCTGCTGAAGGGACCGTGGGACGCTCCCCTGGACCCGGGCCTGACCTCTATTCAGCTCCCATTTTCTCCAGCAATTATTCAAG
CCGAAGTGGAACAGCTGCTGGGGCCGTACCACCCCCACATCCTGTCAGTCACCCTTCTCCAGGACATAATGTACAGGGGAGCCCTCACAA
CCCCTCCTCCCAGTTACCTCCACTCACAGCTGTGGACGCAGGAGCTGAGAGGTTTGCACCTTCTGCTCCATCTCCTCACCACATCAGCCC
CCGGAGAGTTCCAGCTCCTTCTTCAATACTGCAAAGAACACAGCCTCCCTATACCCAGCAGCCATCAGGTTCACACCTGAAGTCCTATCA
GCCAGAAACAAACTCTTCTTTTCAACCAAATGGTATCCATGTCCATGGATTTTATGGGCAGCTGCAGAAGTTCTGTCCCCCACACTACCC
CGATTCCCAGAGAATTGTGCCGCCTGTCAGCTCCTGCAGTGTGGTGCCTTCGTTTGAGGACTGCCTAGTCCCTACATCCATGGGCCAGGC
CAGTTTTGATGTTTTCCACAGAGCCTTCTCGACTCACTCGGGCATTACAGTGTATGATTTACCTTCAAGTTCCTCGAGCCTCTTTGGGGA
GTCTCTCCGCAGCGGGGCTGAAGATGCTACCTTCTTGCAGATCAGCACCGTGGACCGCTGTCCTAGCCAGCTCTCCTCTGTCTACACCGA
AGGCTAAAAGCTCTCTTGGCCACTCCTGCACACCCAGGACCTTGATGTTGCTTGCCACCTTTTGTTTTCGTACTCTCACAGACTGCTTGA
GGAAGGATGTCAGCCCAATCAGCGGGCCCTGCAGAGTTACTGATGTTCTTTCAGAAGGCAGGACTGAATGGCAGAGCTAGCTTTGCAGGA
ATCATTACAGTTGCTCCTTTTTCTCTCTGGTTTTCCTGGACTATGTGACCAGGAGGACTGTCTTTTCAAAGGGAATTTAGAGCCTCACTC
TCCTGGATACCTGTTACTTCCTGGCTGTCAACCCTTAAAGGACCCCAGTGAAATGATGTGCATATGAAAATGTAGTTTGGGGATGACTCT
ACCTGAAAACTCCAAACAGGGAAAAAGACCTCAATTACGAGAGGCATAGTGACCTGCCTCACCTAATCCTCACCCTTGCTGCTCCTGATG
CAAAGCCAGGCACAACAAGGGAAATCCATGTCCAAAGCATAGTGTGGTCTCAACTCTTAGAAACTCCCTGGGTTTCCCTTTTCTCTTAGC

>85579_85579_2_SPATA6L-GLIS3_SPATA6L_chr9_4661899_ENST00000381890_GLIS3_chr9_3937189_ENST00000381971_length(amino acids)=440AA_BP=1
MVQGSAQKDLLIPVLSPTQGTMPLEVVVELQIRAISCPGVFLPGKQDVYLGVYLMNQYLETNSFPSAFPIMIQESMRFEKFEGCEKAFSR
LENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHP
DLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAV
DAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSS

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Fusion Gene PPI Analysis for SPATA6L-GLIS3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SPATA6L-GLIS3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SPATA6L-GLIS3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source