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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SPATA7-GABRA3 (FusionGDB2 ID:85586)

Fusion Gene Summary for SPATA7-GABRA3

Fusion gene summary

Fusion gene information	Fusion gene name: SPATA7-GABRA3
	Fusion gene ID: 85586
		Hgene	Tgene
	Gene symbol	SPATA7	GABRA3
	Gene ID	55812	2556
	Gene name	spermatogenesis associated 7	gamma-aminobutyric acid type A receptor subunit alpha3
	Synonyms	HEL-S-296\|HSD-3.1\|HSD3\|LCA3	-
	Cytomap	14q31.3	Xq28
	Type of gene	protein-coding	protein-coding
	Description	spermatogenesis-associated protein 7epididymis secretory protein Li 296epididymis secretory sperm binding proteinspermatogenesis-associated protein HSD3	gamma-aminobutyric acid receptor subunit alpha-3GABA(A) receptor subunit alpha-3GABA(A) receptor, alpha 3gamma-aminobutyric acid (GABA) A receptor, alpha 3gamma-aminobutyric acid type A receptor alpha3 subunitgamma-animobutyric acid (GABA) A receptor
	Modification date	20200328	20200313
	UniProtAcc	.	P34903
	Ensembl transtripts involved in fusion gene	ENST00000045347, ENST00000356583, ENST00000393545, ENST00000556553, ENST00000554102,	ENST00000497894, ENST00000535043, ENST00000370314,
Fusion gene scores	* DoF score	3 X 3 X 3=27	8 X 6 X 6=288
	# samples	3	7
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/288*10)=-2.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SPATA7 [Title/Abstract] AND GABRA3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SPATA7(88904247)-GABRA3(151337035), # samples:1
Anticipated loss of major functional domain due to fusion event.	SPATA7-GABRA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SPATA7-GABRA3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SPATA7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GABRA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A4SA-01A	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-

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Fusion Gene ORF analysis for SPATA7-GABRA3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000045347	ENST00000497894	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
5CDS-intron	ENST00000356583	ENST00000497894	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
5CDS-intron	ENST00000393545	ENST00000497894	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
5CDS-intron	ENST00000556553	ENST00000497894	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
Frame-shift	ENST00000045347	ENST00000535043	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
Frame-shift	ENST00000356583	ENST00000535043	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
Frame-shift	ENST00000393545	ENST00000370314	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
Frame-shift	ENST00000556553	ENST00000370314	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
Frame-shift	ENST00000556553	ENST00000535043	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
In-frame	ENST00000045347	ENST00000370314	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
In-frame	ENST00000356583	ENST00000370314	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
In-frame	ENST00000393545	ENST00000535043	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
intron-3CDS	ENST00000554102	ENST00000370314	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
intron-3CDS	ENST00000554102	ENST00000535043	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-
intron-intron	ENST00000554102	ENST00000497894	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393545	SPATA7	chr14	88904247	-	ENST00000535043	GABRA3	chrX	151337035	-	2393	2057	289	2022	577
ENST00000356583	SPATA7	chr14	88904247	-	ENST00000370314	GABRA3	chrX	151337035	-	4179	1849	175	1812	545
ENST00000045347	SPATA7	chr14	88904247	-	ENST00000370314	GABRA3	chrX	151337035	-	3611	1281	0	1616	538

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393545	ENST00000535043	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-	0.002710931	0.99728906
ENST00000356583	ENST00000370314	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-	0.001053594	0.99894637
ENST00000045347	ENST00000370314	SPATA7	chr14	88904247	-	GABRA3	chrX	151337035	-	0.001822319	0.99817765

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Fusion Genomic Features for SPATA7-GABRA3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPATA7-GABRA3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:88904247/chrX:151337035)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GABRA3 P34903
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000370314

458_479

381

493.0

Transmembrane

Helical

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000535043

458_479

381

493.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000370314

29_276

381

493.0

Topological domain

Extracellular

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000370314

360_457

381

493.0

Topological domain

Cytoplasmic

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000535043

29_276

381

493.0

Topological domain

Extracellular

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000535043

360_457

381

493.0

Topological domain

Cytoplasmic

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000370314

277_298

381

493.0

Transmembrane

Helical

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000370314

304_325

381

493.0

Transmembrane

Helical

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000370314

338_359

381

493.0

Transmembrane

Helical

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000535043

277_298

381

493.0

Transmembrane

Helical

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000535043

304_325

381

493.0

Transmembrane

Helical

Tgene

GABRA3

chr14:88904247

chrX:151337035

ENST00000535043

338_359

381

493.0

Transmembrane

Helical

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Fusion Gene Sequence for SPATA7-GABRA3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>85586_85586_1_SPATA7-GABRA3_SPATA7_chr14_88904247_ENST00000045347_GABRA3_chrX_151337035_ENST00000370314_length(transcript)=3611nt_BP=1281nt
ATGGATGGCAGCCGGAGAGTCAGAGCAACCTCTGTCCTTCCCAGATATGGTCCACCGTGCCTATTTAAAGGACACTTGAGCACCAAAAGT
AATGCTTTTTGCACTGACTCCTCTTCTCTCAGACTAAGCACTCTCCAGCTGGTCAAGAATCACATGGCTGTTCACTATAATAAAATCCTT
TCAGCCAAAGCTGCAGTAGACTGCTCGGTTCCAGTAAGCGTGAGTACCAGCATAAAGTATGCAGACCAACAACGAAGAGAGAAACTCAAA
AAGGAATTAGCACAATGTGAAAAAGAGTTCAAATTAACTAAAACTGCAATGCGAGCCAATTATAAAAATAATTCCAAGTCACTTTTTAAT
ACCTTACAAAAGCCCTCAGGCGAACCGCAAATTGAGGATGACATGTTAAAAGAAGAAATGAATGGATTTTCATCCTTTGCAAGGTCACTA
GTACCCTCTTCAGAGAGACTACACCTAAGTCTACATAAATCCAGTAAAGTCATCACAAATGGTCCTGAGAAGAACTCCAGTTCCTCCCCG
TCCAGTGTGGATTATGCAGCCTCCGGGCCCCGGAAACTGAGCTCTGGAGCCCTGTATGGCAGAAGGCCCAGAAGCACATTCCCAAATTCC
CACCGGTTTCAGTTAGTCATTTCGAAAGCACCCAGTGGGGATCTTTTGGATAAACATTCTGAACTCTTTTCTAACAAACAATTGCCATTC
ACTCCTCGCACTTTAAAAACAGAAGCAAAATCTTTCCTGTCACAGTATCGCTATTATACACCTGCCAAAAGAAAAAAGGATTTTACAGAT
CAACGGATAGAAGCTGAAACCCAGACTGAATTAAGCTTTAAATCTGAGTTGGGGACAGCTGAGACTAAAAACATGACAGATTCAGAAATG
AACATAAAGCAGGCATCTAATTGTGTGACATATGATGCCAAAGAAAAAATAGCTCCTTTACCTTTAGAAGGGCATGACTCAACATGGGAT
GAGATTAAGGATGATGCTCTTCAGCATTCCTCACCAAGGGCAATGTGTCAGTATTCCCTGAAGCCCCCTTCAACTCGTAAAATCTACTCT
GATGAAGAAGAACTGTTGTATCTGAGTTTCATTGAAGATGTAACAGATGAAATTTTGAAACTTGGTTTATTTTCAAACAGGTTTTTAGAA
CGACTGTTCGAGCGACATATAAAACAAAATAAACATTTGGAGGAGGAAAAAATGCGCCACCTGCTGCATGTCCTGAAAGTAGACTTAGGC
TGCACATCGGAGGAAAACTCGAAGAAAACACCAGCAGCCCCAGCAAAGAAAACCAGCACTACCTTCAACATCGTGGGGACCACCTATCCC
ATCAACCTGGCCAAGGACACTGAATTTTCCACCATCTCCAAGGGCGCTGCTCCCAGTGCCTCCTCAACCCCAACAATCATTGCTTCACCC
AAGGCCACCTACGTGCAGGACAGCCCGACTGAGACCAAGACCTACAACAGTGTCAGCAAGGTTGACAAAATTTCCCGCATCATCTTTCCT
GTGCTCTTTGCCATATTCAATCTGGTCTATTGGGCCACATATGTCAACCGGGAGTCAGCTATCAAGGGCATGATCCGCAAACAGTAGATA
GTGGTGGCAGTGCAGCAACCAGAGCACTGTATACCCCGTGAAGCATCCAGGCACCCAAACCCCGGGGCTCCCCTTCGCGTATTTCAGGAT
TCTCCTTTTTACCCCTCTACCAAGCTGTGACCCTCAATTCATATTTATGAATCTCTACGCAAAAAATAACTACAGAAAAATTACTTGTCC
CTCCAATATTGCCCAGTATAACCCCATCAAAGCCAAACACTGCCATTTGTCCAGTTGCTCATCTTAGTCTGCCAATCTCCCCTAGCTGAG
GGCACTGCATGTATTTTATTGCACTCTGCCCGCTGCAAAAAGAACAAGAGATTCTACTCTCCATAGTGGAAGCCTTGGCTGTTTGAGAGG
CCCAGAACAAGGAGAATTGTTGACTCCCATCTAGATCAGATGACTCTAACTTACTAGGCAGCCAGGTTAGGCTAGGCCATGTGATCCTGC
GTGCCACCTCCCCTGCCTTCAGCAAGGCCTACTAGGCATAAGTACTGATAGCAAAGGTGGGAGCCAGTTCTACACCCCCAACCCATTTAT
TGGTTTGGAAATTAGTGGGGACAATTGGTACTAACCACCGTCTACCATGTATGGCCAAAATAAATAGAACTAGCTCTGCCAGCCTGGCAC
CAAGATGGCTGGTGCCCTGCCATGTCCAGCCCCTCGGGAAAATAGTCCCCTCCTTGGTACATCTCTCCTCCAGAAAATCTTCTTCCCCCA
CTGCCTTTGGCACCCTTGTAGCCAACTGAGCACTACTTAATTTGGACTCATTACCACCTGTAAACTTTTCAGGAAAAAATGATCAAGCAT
TTTTTATTTATATCGAAAAGTTGCAAATAGAAACAAAGTGATCTAGATTTAAAAAAAACATTTTTTTAAAATATGGGAGAGATACAAAAG
TCACCTCCCTGCCAAGGCAACTAGCCTATACTGGATTGGGTAAGAGGTTTGGAGTGGATGGTAGTTGAGGATTGAAGTCTGGCTCAAAAG
AGAAGGCTACTGGCAGATGAAAGTCAAATTCTTCCTTCCATACACTCCACATTCCACACCCTGGCCCAGGCACTTTTCTCCCACCATATC
GGGAACCTCCGGTCCTCTGTTGATGCCGATTCTATGAGGGGTGAATTGGAAATTCATACAAATAAATATCTCTAGTCAATATTGAGTCAA
CTAGATCATTAACTTTATTGCCAATTTTATAATATATTATTTAGAGGCCATTTGTTCTTAATCTTAATGTGAGTAAAAGACACAGGCATA
AATACGCAATTTTTATAAGGTAGATAAACTGAATCCCAGAAGTTTGAATGATTTGCCTAGGCTCCTTACAAGTGTCTTTAATAAAGAGCT
ATCGTGCGCCCCTTTCCAAAGGCCAAAATAAAGGACTGAGAAGCCAGGTCCACCGTGACCTCAGAATCAGCACAATCTCAGCGGGCCTTC
TGGGTCACTAGTGGAACTTGGTTGGGCACCAAAAAGGTTTTTAGAAAGTCACAATGTGTCACCCAAGAAGATCACTTTTAATAGTCTCAG
CCCAAGAGAATGAGACTGTTTATGATGGCAGCCCCAGCCACTTTGGCTCTGAATACCTGCACTAGTCCAGAGTATCCTAGAAGCCCAGGG
TAAAGCCACAGAGGGCACCACAAGCAGATTCTCCCTGCCCACCGGCTGAACAAAGCTCCTAAGGGGTGTATCATTAGCTGCTGGTTGCCT
TTTCATCCATCCTTTCCCCGTCCCCTGCTTCCTTGCCATTGCTGGGATAATGCATGCCCGTCCCATTATTCCTAAGACTGTGTCTGTAGG
TAAATTCATGACTAGAAGAGTGTAGTCTTGTGGATATGTGGGGATATGGGGGGTGGGAGGGCGGGGCTGTTAATGGTTGTCTTAAGGAAC
TTAGAATGGAAGCCTGATCTTTGCCTCTCTGTAGAAATTGTGTTTCCAAATGCTTTGGTGCAATGTTTAGCTGCTGTTTATTAAACCCTT

>85586_85586_1_SPATA7-GABRA3_SPATA7_chr14_88904247_ENST00000045347_GABRA3_chrX_151337035_ENST00000370314_length(amino acids)=538AA_BP=427
MDGSRRVRATSVLPRYGPPCLFKGHLSTKSNAFCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPVSVSTSIKYADQQRREKLK
KELAQCEKEFKLTKTAMRANYKNNSKSLFNTLQKPSGEPQIEDDMLKEEMNGFSSFARSLVPSSERLHLSLHKSSKVITNGPEKNSSSSP
SSVDYAASGPRKLSSGALYGRRPRSTFPNSHRFQLVISKAPSGDLLDKHSELFSNKQLPFTPRTLKTEAKSFLSQYRYYTPAKRKKDFTD
QRIEAETQTELSFKSELGTAETKNMTDSEMNIKQASNCVTYDAKEKIAPLPLEGHDSTWDEIKDDALQHSSPRAMCQYSLKPPSTRKIYS
DEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHLEEEKMRHLLHVLKVDLGCTSEENSKKTPAAPAKKTSTTFNIVGTTYP

--------------------------------------------------------------
>85586_85586_2_SPATA7-GABRA3_SPATA7_chr14_88904247_ENST00000356583_GABRA3_chrX_151337035_ENST00000370314_length(transcript)=4179nt_BP=1849nt
ACAATAGCGACTCACTGGACCCAGCCCTTAGCAACGGCCTGGCAACGGTTTCCCTGCTGCTGCAGCCCCCGTCGGCTCCTCTTTTCCAGT
CCTCCACTGCCGGGGCTGGGCCCGGCCGCGGGAAGGACCGAAGGGGATACAGCGTGTCCCTGCGGCGGCTGCAAGAGGACTAAGCATGGA
TGGCAGCCGGAGAGTCAGAGCAACCTCTGTCCTTCCCAGATATGGTCCACCGTGCCTATTTAAAGGACACTTGAGCACCAAAAGTAATGC
TGCAGTAGACTGCTCGGTTCCAGTAAGCGTGAGTACCAGCATAAAGTATGCAGACCAACAACGAAGAGAGAAACTCAAAAAGGAATTAGC
ACAATGTGAAAAAGAGTTCAAATTAACTAAAACTGCAATGCGAGCCAATTATAAAAATAATTCCAAGTCACTTTTTAATACCTTACAAAA
GCCCTCAGGCGAACCGCAAATTGAGGATGACATGTTAAAAGAAGAAATGAATGGATTTTCATCCTTTGCAAGGTCACTAGTACCCTCTTC
AGAGAGACTACACCTAAGTCTACATAAATCCAGTAAAGTCATCACAAATGGTCCTGAGAAGAACTCCAGTTCCTCCCCGTCCAGTGTGGA
TTATGCAGCCTCCGGGCCCCGGAAACTGAGCTCTGGAGCCCTGTATGGCAGAAGGCCCAGAAGCACATTCCCAAATTCCCACCGGTTTCA
GTTAGTCATTTCGAAAGCACCCAGTGGGGATCTTTTGGATAAACATTCTGAACTCTTTTCTAACAAACAATTGCCATTCACTCCTCGCAC
TTTAAAAACAGAAGCAAAATCTTTCCTGTCACAGTATCGCTATTATACACCTGCCAAAAGAAAAAAGGATTTTACAGATCAACGGATAGA
AGCTGAAACCCAGACTGAATTAAGCTTTAAATCTGAGTTGGGGACAGCTGAGACTAAAAACATGACAGATTCAGAAATGAACATAAAGCA
GGCATCTAATTGTGTGACATATGATGCCAAAGAAAAAATAGCTCCTTTACCTTTAGAAGGGCATGACTCAACATGGGATGAGATTAAGGA
TGATGCTCTTCAGCATTCCTCACCAAGGGCAATGTGTCAGTATTCCCTGAAGCCCCCTTCAACTCGTAAAATCTACTCTGATGAAGAAGA
ACTGTTGTATCTGAGTTTCATTGAAGATGTAACAGATGAAATTTTGAAACTTGGTTTATTTTCAAACAGGTTTTTAGAACGACTGTTCGA
GCGACATATAAAACAAAATAAACATTTGGAGGAGGTAAAGCAAAATGATGTTGATATGTTGAATGTATTTGATTTTGAAAAGGCTGGGAA
TTCAGAACCAAATGAATTAAAAAATGAAAGTGAAGTAACAATTCAGCAGGAACGTCAACAATACCAAAAGGCTTTGGATATGTTATTGTC
GGCACCAAAGGATGAGAACGAGATATTCCCTTCACCAACTGAATTTTTCATGCCTATTTATAAATCAAAGCATTCAGAAGGGGTTATAAT
TCAACAGGTGAATGATGAAACAAATCTTGAAACTTCAACTTTGGATGAAAATCATCCAAGTATTTCAGACAGTTTAACAGATCGGGAAAC
TTCTGTGAATGTCATTGAAGGTGATAGTGACCCTGAAAAGGTTGAGATTTCAAATGGATTATGTGGTCTTAACACATCACCCTCCCAATC
TGTTCAGTTCTCCAGTGTCAAAGGCGACAATAATCATGACATGGAGTTATCAACTCTTAAAATCATGGAAATGAGCATTGAGGACTGCCC
TTTGGATGTTTAATCTTCATTAATAAATACCTCAAATGGCCAGTAACTCAAGAAAACACCAGCAGCCCCAGCAAAGAAAACCAGCACTAC
CTTCAACATCGTGGGGACCACCTATCCCATCAACCTGGCCAAGGACACTGAATTTTCCACCATCTCCAAGGGCGCTGCTCCCAGTGCCTC
CTCAACCCCAACAATCATTGCTTCACCCAAGGCCACCTACGTGCAGGACAGCCCGACTGAGACCAAGACCTACAACAGTGTCAGCAAGGT
TGACAAAATTTCCCGCATCATCTTTCCTGTGCTCTTTGCCATATTCAATCTGGTCTATTGGGCCACATATGTCAACCGGGAGTCAGCTAT
CAAGGGCATGATCCGCAAACAGTAGATAGTGGTGGCAGTGCAGCAACCAGAGCACTGTATACCCCGTGAAGCATCCAGGCACCCAAACCC
CGGGGCTCCCCTTCGCGTATTTCAGGATTCTCCTTTTTACCCCTCTACCAAGCTGTGACCCTCAATTCATATTTATGAATCTCTACGCAA
AAAATAACTACAGAAAAATTACTTGTCCCTCCAATATTGCCCAGTATAACCCCATCAAAGCCAAACACTGCCATTTGTCCAGTTGCTCAT
CTTAGTCTGCCAATCTCCCCTAGCTGAGGGCACTGCATGTATTTTATTGCACTCTGCCCGCTGCAAAAAGAACAAGAGATTCTACTCTCC
ATAGTGGAAGCCTTGGCTGTTTGAGAGGCCCAGAACAAGGAGAATTGTTGACTCCCATCTAGATCAGATGACTCTAACTTACTAGGCAGC
CAGGTTAGGCTAGGCCATGTGATCCTGCGTGCCACCTCCCCTGCCTTCAGCAAGGCCTACTAGGCATAAGTACTGATAGCAAAGGTGGGA
GCCAGTTCTACACCCCCAACCCATTTATTGGTTTGGAAATTAGTGGGGACAATTGGTACTAACCACCGTCTACCATGTATGGCCAAAATA
AATAGAACTAGCTCTGCCAGCCTGGCACCAAGATGGCTGGTGCCCTGCCATGTCCAGCCCCTCGGGAAAATAGTCCCCTCCTTGGTACAT
CTCTCCTCCAGAAAATCTTCTTCCCCCACTGCCTTTGGCACCCTTGTAGCCAACTGAGCACTACTTAATTTGGACTCATTACCACCTGTA
AACTTTTCAGGAAAAAATGATCAAGCATTTTTTATTTATATCGAAAAGTTGCAAATAGAAACAAAGTGATCTAGATTTAAAAAAAACATT
TTTTTAAAATATGGGAGAGATACAAAAGTCACCTCCCTGCCAAGGCAACTAGCCTATACTGGATTGGGTAAGAGGTTTGGAGTGGATGGT
AGTTGAGGATTGAAGTCTGGCTCAAAAGAGAAGGCTACTGGCAGATGAAAGTCAAATTCTTCCTTCCATACACTCCACATTCCACACCCT
GGCCCAGGCACTTTTCTCCCACCATATCGGGAACCTCCGGTCCTCTGTTGATGCCGATTCTATGAGGGGTGAATTGGAAATTCATACAAA
TAAATATCTCTAGTCAATATTGAGTCAACTAGATCATTAACTTTATTGCCAATTTTATAATATATTATTTAGAGGCCATTTGTTCTTAAT
CTTAATGTGAGTAAAAGACACAGGCATAAATACGCAATTTTTATAAGGTAGATAAACTGAATCCCAGAAGTTTGAATGATTTGCCTAGGC
TCCTTACAAGTGTCTTTAATAAAGAGCTATCGTGCGCCCCTTTCCAAAGGCCAAAATAAAGGACTGAGAAGCCAGGTCCACCGTGACCTC
AGAATCAGCACAATCTCAGCGGGCCTTCTGGGTCACTAGTGGAACTTGGTTGGGCACCAAAAAGGTTTTTAGAAAGTCACAATGTGTCAC
CCAAGAAGATCACTTTTAATAGTCTCAGCCCAAGAGAATGAGACTGTTTATGATGGCAGCCCCAGCCACTTTGGCTCTGAATACCTGCAC
TAGTCCAGAGTATCCTAGAAGCCCAGGGTAAAGCCACAGAGGGCACCACAAGCAGATTCTCCCTGCCCACCGGCTGAACAAAGCTCCTAA
GGGGTGTATCATTAGCTGCTGGTTGCCTTTTCATCCATCCTTTCCCCGTCCCCTGCTTCCTTGCCATTGCTGGGATAATGCATGCCCGTC
CCATTATTCCTAAGACTGTGTCTGTAGGTAAATTCATGACTAGAAGAGTGTAGTCTTGTGGATATGTGGGGATATGGGGGGTGGGAGGGC
GGGGCTGTTAATGGTTGTCTTAAGGAACTTAGAATGGAAGCCTGATCTTTGCCTCTCTGTAGAAATTGTGTTTCCAAATGCTTTGGTGCA

>85586_85586_2_SPATA7-GABRA3_SPATA7_chr14_88904247_ENST00000356583_GABRA3_chrX_151337035_ENST00000370314_length(amino acids)=545AA_BP=
MDGSRRVRATSVLPRYGPPCLFKGHLSTKSNAAVDCSVPVSVSTSIKYADQQRREKLKKELAQCEKEFKLTKTAMRANYKNNSKSLFNTL
QKPSGEPQIEDDMLKEEMNGFSSFARSLVPSSERLHLSLHKSSKVITNGPEKNSSSSPSSVDYAASGPRKLSSGALYGRRPRSTFPNSHR
FQLVISKAPSGDLLDKHSELFSNKQLPFTPRTLKTEAKSFLSQYRYYTPAKRKKDFTDQRIEAETQTELSFKSELGTAETKNMTDSEMNI
KQASNCVTYDAKEKIAPLPLEGHDSTWDEIKDDALQHSSPRAMCQYSLKPPSTRKIYSDEEELLYLSFIEDVTDEILKLGLFSNRFLERL
FERHIKQNKHLEEVKQNDVDMLNVFDFEKAGNSEPNELKNESEVTIQQERQQYQKALDMLLSAPKDENEIFPSPTEFFMPIYKSKHSEGV
IIQQVNDETNLETSTLDENHPSISDSLTDRETSVNVIEGDSDPEKVEISNGLCGLNTSPSQSVQFSSVKGDNNHDMELSTLKIMEMSIED

--------------------------------------------------------------
>85586_85586_3_SPATA7-GABRA3_SPATA7_chr14_88904247_ENST00000393545_GABRA3_chrX_151337035_ENST00000535043_length(transcript)=2393nt_BP=2057nt
GACTGGGGCTCGATGCCCCTTCCCCGCCAGGTCTCTCCGTCCGCAACTGTCCTCCTAGTACCGGGTATCCCGCAGGCGGGGCTGCGGAAC
GCACGTCCCCTGCGCCGTGACGTCACAATAGCGACTCACTGGACCCAGCCCTTAGCAACGGCCTGGCAACGGTTTCCCTGCTGCTGCAGC
CCCCGTCGGCTCCTCTTTTCCAGTCCTCCACTGCCGGGGCTGGGCCCGGCCGCGGGAAGGACCGAAGGGGATACAGCGTGTCCCTGCGGC
GGCTGCAAGAGGACTAAGCATGGATGGCAGCCGGAGAGTCAGAGCAACCTCTGTCCTTCCCAGATATGGTCCACCGTGCCTATTTAAAGG
ACACTTGAGCACCAAAAGTAATGCTTTTTGCACTGACTCCTCTTCTCTCAGACTAAGCACTCTCCAGCTGGTCAAGAATCACATGGCTGT
TCACTATAATAAAATCCTTTCAGCCAAAGCTGCAGTAGACTGCTCGGTTCCAGTAAGCGTGAGTACCAGCATAAAGTATGCAGACCAACA
ACGAAGAGAGAAACTCAAAAAGGAATTAGCACAATGTGAAAAAGAGTTCAAATTAACTAAAACTGCAATGCGAGCCAATTATAAAAATAA
TTCCAAGTCACTTTTTAATACCTTACAAAAGCCCTCAGGCGAACCGCAAATTGAGGATGACATGTTAAAAGAAGAAATGAATGGATTTTC
ATCCTTTGCAAGGTCACTAGTACCCTCTTCAGAGAGACTACACCTAAGTCTACATAAATCCAGTAAAGTCATCACAAATGGTCCTGAGAA
GAACTCCAGTTCCTCCCCGTCCAGTGTGGATTATGCAGCCTCCGGGCCCCGGAAACTGAGCTCTGGAGCCCTGTATGGCAGAAGGCCCAG
AAGCACATTCCCAAATTCCCACCGGTTTCAGTTAGTCATTTCGAAAGCACCCAGTGGGGATCTTTTGGATAAACATTCTGAACTCTTTTC
TAACAAACAATTGCCATTCACTCCTCGCACTTTAAAAACAGAAGCAAAATCTTTCCTGTCACAGTATCGCTATTATACACCTGCCAAAAG
AAAAAAGGATTTTACAGATCAACGGATAGAAGCTGAAACCCAGACTGAATTAAGCTTTAAATCTGAGTTGGGGACAGCTGAGACTAAAAA
CATGACAGATTCAGAAATGAACATAAAGCAGGCATCTAATTGTGTGACATATGATGCCAAAGAAAAAATAGCTCCTTTACCTTTAGAAGG
GCATGACTCAACATGGGATGAGATTAAGGATGATGCTCTTCAGCATTCCTCACCAAGGGCAATGTGTCAGTATTCCCTGAAGCCCCCTTC
AACTCGTAAAATCTACTCTGATGAAGAAGAACTGTTGTATCTGAGTTTCATTGAAGATGTAACAGATGAAATTTTGAAACTTGGTTTATT
TTCAAACAGGTTTTTAGAACGACTGTTCGAGCGACATATAAAACAAAATAAACATTTGGAGGAGGTAAAGCAAAATGATGTTGATATGTT
GAATGTATTTGATTTTGAAAAGGCTGGGAATTCAGAACCAAATGAATTAAAAAATGAAAGTGAAGTAACAATTCAGCAGGAACGTCAACA
ATACCAAAAGGCTTTGGATATGTTATTGTCGGCACCAAAGGATGAGAACGAGATATTCCCTTCACCAACTGAATTTTTCATGCCTATTTA
TAAATCAAAGCATTCAGAAGGGGTTATAATTCAACAGGTGAATGATGAAACAAATCTTGAAACTTCAACTTTGGATGAAAATCATCCAAG
TATTTCAGACAGTTTAACAGATCGGGAAACTTCTGTGAATGTCATTGAAGGTGATAGTGACCCTGAAAAGGTTGAGATTTCAAATGGATT
ATGTGGTCTTAACACATCACCCTCCCAATCTGTTCAGTTCTCCAGTGTCAAAGGCGACAATAATCATGACATGGAGTTATCAACTCTTAA
AATCATGGAAATGAGCATTGAGGACTGCCCTTTGGATGTTTAATCTTCATTAATAAATACCTCAAATGGCCAGTAACAAGAAAACACCAG
CAGCCCCAGCAAAGAAAACCAGCACTACCTTCAACATCGTGGGGACCACCTATCCCATCAACCTGGCCAAGGACACTGAATTTTCCACCA
TCTCCAAGGGCGCTGCTCCCAGTGCCTCCTCAACCCCAACAATCATTGCTTCACCCAAGGCCACCTACGTGCAGGACAGCCCGACTGAGA
CCAAGACCTACAACAGTGTCAGCAAGGTTGACAAAATTTCCCGCATCATCTTTCCTGTGCTCTTTGCCATATTCAATCTGGTCTATTGGG

>85586_85586_3_SPATA7-GABRA3_SPATA7_chr14_88904247_ENST00000393545_GABRA3_chrX_151337035_ENST00000535043_length(amino acids)=577AA_BP=
MDGSRRVRATSVLPRYGPPCLFKGHLSTKSNAFCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPVSVSTSIKYADQQRREKLK
KELAQCEKEFKLTKTAMRANYKNNSKSLFNTLQKPSGEPQIEDDMLKEEMNGFSSFARSLVPSSERLHLSLHKSSKVITNGPEKNSSSSP
SSVDYAASGPRKLSSGALYGRRPRSTFPNSHRFQLVISKAPSGDLLDKHSELFSNKQLPFTPRTLKTEAKSFLSQYRYYTPAKRKKDFTD
QRIEAETQTELSFKSELGTAETKNMTDSEMNIKQASNCVTYDAKEKIAPLPLEGHDSTWDEIKDDALQHSSPRAMCQYSLKPPSTRKIYS
DEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHLEEVKQNDVDMLNVFDFEKAGNSEPNELKNESEVTIQQERQQYQKALD
MLLSAPKDENEIFPSPTEFFMPIYKSKHSEGVIIQQVNDETNLETSTLDENHPSISDSLTDRETSVNVIEGDSDPEKVEISNGLCGLNTS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SPATA7-GABRA3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SPATA7-GABRA3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SPATA7-GABRA3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source