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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AXIN1-MYO19 (FusionGDB2 ID:8563)

Fusion Gene Summary for AXIN1-MYO19

Fusion gene summary

Fusion gene information	Fusion gene name: AXIN1-MYO19
	Fusion gene ID: 8563
		Hgene	Tgene
	Gene symbol	AXIN1	MYO19
	Gene ID	8312	80179
	Gene name	axin 1	myosin XIX
	Synonyms	AXIN\|PPP1R49	MYOHD1
	Cytomap	16p13.3	17q12
	Type of gene	protein-coding	protein-coding
	Description	axin-1axis inhibition protein 1axis inhibitor 1fused, mouse, homolog ofprotein phosphatase 1, regulatory subunit 49	unconventional myosin-XIXmyosin head domain containing 1myosin head domain-containing protein 1
	Modification date	20200322	20200313
	UniProtAcc	O15169	Q96H55
	Ensembl transtripts involved in fusion gene	ENST00000262320, ENST00000354866, ENST00000481769,	ENST00000544606, ENST00000586007, ENST00000590081, ENST00000268852, ENST00000431794,
Fusion gene scores	* DoF score	16 X 10 X 9=1440	8 X 9 X 5=360
	# samples	23	10
	** MAII score	log2(23/1440*10)=-2.6463630453853 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AXIN1 [Title/Abstract] AND MYO19 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AXIN1(354304)-MYO19(34867294), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AXIN1	GO:0001934	positive regulation of protein phosphorylation	9601641
Hgene	AXIN1	GO:0032147	activation of protein kinase activity	9601641
Hgene	AXIN1	GO:0034622	cellular protein-containing complex assembly	16601693
Hgene	AXIN1	GO:0045732	positive regulation of protein catabolic process	9601641
Hgene	AXIN1	GO:0090090	negative regulation of canonical Wnt signaling pathway	10644691
Tgene	MYO19	GO:0034642	mitochondrion migration along actin filament	19932026

Fusion gene breakpoints across AXIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8296-01A	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-

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Fusion Gene ORF analysis for AXIN1-MYO19

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262320	ENST00000544606	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5CDS-intron	ENST00000262320	ENST00000586007	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5CDS-intron	ENST00000262320	ENST00000590081	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5CDS-intron	ENST00000354866	ENST00000544606	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5CDS-intron	ENST00000354866	ENST00000586007	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5CDS-intron	ENST00000354866	ENST00000590081	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5UTR-3CDS	ENST00000481769	ENST00000268852	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5UTR-3CDS	ENST00000481769	ENST00000431794	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5UTR-intron	ENST00000481769	ENST00000544606	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5UTR-intron	ENST00000481769	ENST00000586007	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
5UTR-intron	ENST00000481769	ENST00000590081	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
In-frame	ENST00000262320	ENST00000268852	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
In-frame	ENST00000262320	ENST00000431794	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
In-frame	ENST00000354866	ENST00000268852	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-
In-frame	ENST00000354866	ENST00000431794	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262320	AXIN1	chr16	354304	-	ENST00000431794	MYO19	chr17	34867294	-	4263	1626	21	3644	1207
ENST00000262320	AXIN1	chr16	354304	-	ENST00000268852	MYO19	chr17	34867294	-	3541	1626	21	3044	1007
ENST00000354866	AXIN1	chr16	354304	-	ENST00000431794	MYO19	chr17	34867294	-	4053	1416	15	3434	1139
ENST00000354866	AXIN1	chr16	354304	-	ENST00000268852	MYO19	chr17	34867294	-	3331	1416	15	2834	939

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262320	ENST00000431794	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-	0.006166686	0.9938333
ENST00000262320	ENST00000268852	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-	0.007560293	0.99243975
ENST00000354866	ENST00000431794	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-	0.004553649	0.99544626
ENST00000354866	ENST00000268852	AXIN1	chr16	354304	-	MYO19	chr17	34867294	-	0.006818679	0.9931813

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Fusion Genomic Features for AXIN1-MYO19

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AXIN1-MYO19

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:354304/chr17:34867294)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AXIN1 O15169	MYO19 Q96H55
FUNCTION: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269\|PubMed:12192039, ECO:0000269\|PubMed:16601693, ECO:0000269\|PubMed:17210684, ECO:0000269\|PubMed:27098453}.	FUNCTION: Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). {ECO:0000250\|UniProtKB:Q5SV80, ECO:0000269\|PubMed:19932026, ECO:0000269\|PubMed:25447992, ECO:0000305\|PubMed:23568824}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AXIN1

chr16:354304

chr17:34867294

ENST00000262320

88_211

418

863.0

Domain

RGS

Hgene

AXIN1

chr16:354304

chr17:34867294

ENST00000354866

88_211

418

827.0

Domain

RGS

Hgene

AXIN1

chr16:354304

chr17:34867294

ENST00000262320

20_29

418

863.0

Motif

Note=Tankyrase-binding motif

Hgene

AXIN1

chr16:354304

chr17:34867294

ENST00000354866

20_29

418

827.0

Motif

Note=Tankyrase-binding motif

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000268852

759_779

298

771.0

Domain

IQ 1

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000268852

783_812

298

771.0

Domain

IQ 2

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000431794

759_779

298

971.0

Domain

IQ 1

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000431794

783_812

298

971.0

Domain

IQ 2

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000586007

35_758

318.0

Domain

Myosin motor

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000586007

759_779

318.0

Domain

IQ 1

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000586007

783_812

318.0

Domain

IQ 2

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000586007

132_139

318.0

Nucleotide binding

ATP

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000268852

602_624

298

771.0

Region

Actin-binding

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000268852

824_970

298

771.0

Region

MyMOMA region

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000431794

602_624

298

971.0

Region

Actin-binding

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000431794

824_970

298

971.0

Region

MyMOMA region

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000586007

602_624

318.0

Region

Actin-binding

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000586007

824_970

318.0

Region

MyMOMA region

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AXIN1

chr16:354304

chr17:34867294

ENST00000262320

780_862

418

863.0

Domain

DIX

Hgene

AXIN1

chr16:354304

chr17:34867294

ENST00000354866

780_862

418

827.0

Domain

DIX

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000268852

35_758

298

771.0

Domain

Myosin motor

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000431794

35_758

298

971.0

Domain

Myosin motor

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000268852

132_139

298

771.0

Nucleotide binding

ATP

Tgene

MYO19

chr16:354304

chr17:34867294

ENST00000431794

132_139

298

971.0

Nucleotide binding

ATP

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Fusion Gene Sequence for AXIN1-MYO19

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8563_8563_1_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000268852_length(transcript)=3541nt_BP=1626nt
CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG
GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG
GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG
TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG
CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT
GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT
TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT
GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC
TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA
AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG
ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT
TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA
CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC
TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG
TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG
CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG
AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG
CGCATGGTCCTAGCTGGACTGCTGCACCTTGGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGAT
GCCAAGTACTCTGTCAGGACGGCAGCCTCGCTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCA
GGCAGACAGCAGCAGGTGTTCCGGAAGCCCTGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGG
TTGTTTGACTGGCTGGTATCAGTGATCAACAGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTAT
GGATTTGAATCATTTCCTGACAACAGTCTGGAACAGTTGTGCATCAACTACGCCAATGAGAAGCTCCAGCTGGAGGCCTGTGGCCTCGTG
GAGACCATCCATATCAGTGCTGCTGGCTTCCCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCAT
CCTTGCACATCCTCTGGCCCCGACAGCCCATATCCTGCCAAAGGGCTCCCTGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACCT
CTCATCCAGGACATTCTCCACACTCTGCCGGTCCTAACTCAGGCAGCAGCCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATG
CACTGTGGCAGGACCAAGGTGTTCATGACTGACTCTATGCTGGAGCTTCTGGAATGTGGGCGTGCCCGGGTGCTGGAGCAGTGTGCCCGC
TGCATCCAGGGTGGCTGGAGGCGACACCGGCACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTCATCCAGGCAGCCATTCGTTCC
TGGTTAACTCGGAAACACATCCAGAGGCTGCATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCAGAATGGCCTGC
CTTGCTGCTAAAGAGCTGGATGGTGTGGAAGAAAAACACTTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCTC
CTGGAGGCAATAATCCGCCTCTGGCCCCTGGGACTGGTCCTGGCCAATACGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTC
TGGGCTTGCCTCCAGCTCCCCAGGGGCAGCCCCAGTAGCTACACTGTCCAGACAGCACAAGACCAGGCTGGTGTCACGTCCATCCGAGCG
CTGCCTCAGGGATCGATAAAGTTTCACTGCAGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAACCTTCACCCTACAGCATTACA
GGCTTTAATCAGATTCTGCTGGAAAGACACAGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCTTGGTGCCTTTG
TTTCCACAAGGCCTTTTCCTGCCCCCTGCCTTGCCAAAGACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATGC
ACATGAACAACAGTGACGGCTCCAGCCTTCGACCCAGAGCCCCGTGCCCAGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCAC
TGATGGTGTCAGGGCTGGTAGTTACCAAATCAGGGTTAAGAAACATCAGGGCCACATTTCACTACCTTCACAGATCAAACTCAGCAGCAG
TCATGACTGTCTGTCACTACACTGGGGATCCCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAAGTTGGCCTAAAATTGGCGCTG
GAATTTGGGCTGGGAAAAATCTTGTGGTTATTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATTTAATGTAATTT

>8563_8563_1_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000268852_length(amino acids)=1007AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMVLAGL
LHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVS
VINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGP
DSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQGGWR
RHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFSQAPCSLSTSPLQTRLLEAIIRL
WPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGFNQILL

--------------------------------------------------------------
>8563_8563_2_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000431794_length(transcript)=4263nt_BP=1626nt
CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG
GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG
GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG
TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG
CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT
GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT
TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT
GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC
TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA
AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG
ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT
TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA
CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC
TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG
TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG
CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG
AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG
CGCATGGTCCTAGCTGGACTGCTGCACCTTGGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGAT
GCCAAGTACTCTGTCAGGACGGCAGCCTCGCTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCA
GGCAGACAGCAGCAGGTGTTCCGGAAGCCCTGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGG
TTGTTTGACTGGCTGGTATCAGTGATCAACAGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTAT
GGATTTGAATCATTTCCTGACAACAGTCTGGAACAGTTGTGCATCAACTACGCCAATGAGAAGCTGCAGCAGCATTTTGTGGCTCACTAC
CTAAGGGCCCAGCAGGAGGAATACGCAGTTGAGGGCCTGGAGTGGTCATTCATCAACTACCAGGACAACCAGCCCTGTTTGGATCTCATT
GAGGGAAGCCCCATCAGCATCTGCTCCCTCATAAATGAGGAATGCCGCCTCAATCGACCCAGCAGCGCAGCCCAGCTCCAGACACGCATT
GAGACTGCCCTGGCAGGCAGCCCCTGCCTGGGCCACAATAAGCTCAGCCGGGAGCCCAGCTTCATTGTGGTGCATTATGCGGGGCCTGTG
CGGTACCACACAGCAGGCCTGGTGGAGAAGAACAAGGACCCTATCCCACCTGAGCTGACCAGGCTCCTGCAGCAATCCCAGGACCCCCTG
CTCATGGGGCTGTTTCCTACTAACCCCAAAGAGAAGACCCAGGAGGAACCCCCTGGCCAGAGCAGGGCCCCTGTGTTGACCGTGGTGTCC
AAGTTCAAGGCCTCACTGGAGCAGCTTCTGCAGGTCCTACACAGCACCACGCCCCACTACATTCGCTGCATCAAGCCCAACAGCCAGGGC
CAGGCGCAGACCTTTCTCCAAGAGGAGGTCCTGAGCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTTC
CCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCA
TATCCTGCCAAAGGGCTCCCTGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACCTCTCATCCAGGACATTCTCCACACTCTGCCG
GTCCTAACTCAGGCAGCAGCCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGCAGGACCAAGGTGTTCATGACT
GACTCTATGCTGGAGCTTCTGGAATGTGGGCGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGAGGCGACACCGG
CACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTCATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCTG
CATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCAGAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAA
GAAAAACACTTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCTCCTGGAGGCAATAATCCGCCTCTGGCCCCTG
GGACTGGTCCTGGCCAATACGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGCCTCCAGCTCCCCAGGGGCAGC
CCCAGTAGCTACACTGTCCAGACAGCACAAGACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAAAGTTTCACTGC
AGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAACCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACAC
AGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCTTGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCC
TTGCCAAAGACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATGCACATGAACAACAGTGACGGCTCCAGCCTTC
GACCCAGAGCCCCGTGCCCAGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGTCAGGGCTGGTAGTTACCAAAT
CAGGGTTAAGAAACATCAGGGCCACATTTCACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTACACTGGGGATC
CCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAAGTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTTA
TTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATTTAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGT
ACAGTAGAATCACGTTTTGATTTTATTAACACTGACCAAGTTTAACTCCATATGAAGTGTAAGCTTGATATCGTTTATGATGTCTATCAA

>8563_8563_2_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000262320_MYO19_chr17_34867294_ENST00000431794_length(amino acids)=1207AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMVLAGL
LHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVS
VINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEWSFINYQDNQPCLDLIEGSPISI
CSLINEECRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQDPLLMGLFPT
NPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHR
NFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELL
ECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFSQA
PCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRY

--------------------------------------------------------------
>8563_8563_3_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000268852_length(transcript)=3331nt_BP=1416nt
GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG
ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG
GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC
CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG
GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA
GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG
CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG
TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG
ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG
AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA
TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT
GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC
AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG
GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG
CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG
GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGTCCTAGCTGGACTGCTGCACCTT
GGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGATGCCAAGTACTCTGTCAGGACGGCAGCCTCG
CTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCAGGCAGACAGCAGCAGGTGTTCCGGAAGCCC
TGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGGTTGTTTGACTGGCTGGTATCAGTGATCAAC
AGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTATGGATTTGAATCATTTCCTGACAACAGTCTG
GAACAGTTGTGCATCAACTACGCCAATGAGAAGCTCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTTC
CCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCA
TATCCTGCCAAAGGGCTCCCTGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACCTCTCATCCAGGACATTCTCCACACTCTGCCG
GTCCTAACTCAGGCAGCAGCCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGCAGGACCAAGGTGTTCATGACT
GACTCTATGCTGGAGCTTCTGGAATGTGGGCGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGAGGCGACACCGG
CACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTCATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCTG
CATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCAGAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAA
GAAAAACACTTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCTCCTGGAGGCAATAATCCGCCTCTGGCCCCTG
GGACTGGTCCTGGCCAATACGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGCCTCCAGCTCCCCAGGGGCAGC
CCCAGTAGCTACACTGTCCAGACAGCACAAGACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAAAGTTTCACTGC
AGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAACCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACAC
AGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCTTGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCC
TTGCCAAAGACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATGCACATGAACAACAGTGACGGCTCCAGCCTTC
GACCCAGAGCCCCGTGCCCAGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGTCAGGGCTGGTAGTTACCAAAT
CAGGGTTAAGAAACATCAGGGCCACATTTCACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTACACTGGGGATC
CCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAAGTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTTA
TTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATTTAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGT

>8563_8563_3_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000268852_length(amino acids)=939AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAE
CDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQLEACGLVETIHISAAGFPIRVS
HRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLE
LLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAKELDGVEEKHFS
QAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPL

--------------------------------------------------------------
>8563_8563_4_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000431794_length(transcript)=4053nt_BP=1416nt
GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG
ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG
GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC
CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG
GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA
GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG
CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG
TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG
ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG
AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA
TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT
GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC
AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG
GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG
CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG
GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGTCCTAGCTGGACTGCTGCACCTT
GGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGCCGATGGATGATGCCAAGTACTCTGTCAGGACGGCAGCCTCG
CTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGCAGGCAGACAGCAGCAGGTGTTCCGGAAGCCC
TGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGGTTGTTTGACTGGCTGGTATCAGTGATCAAC
AGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTATGGATTTGAATCATTTCCTGACAACAGTCTG
GAACAGTTGTGCATCAACTACGCCAATGAGAAGCTGCAGCAGCATTTTGTGGCTCACTACCTAAGGGCCCAGCAGGAGGAATACGCAGTT
GAGGGCCTGGAGTGGTCATTCATCAACTACCAGGACAACCAGCCCTGTTTGGATCTCATTGAGGGAAGCCCCATCAGCATCTGCTCCCTC
ATAAATGAGGAATGCCGCCTCAATCGACCCAGCAGCGCAGCCCAGCTCCAGACACGCATTGAGACTGCCCTGGCAGGCAGCCCCTGCCTG
GGCCACAATAAGCTCAGCCGGGAGCCCAGCTTCATTGTGGTGCATTATGCGGGGCCTGTGCGGTACCACACAGCAGGCCTGGTGGAGAAG
AACAAGGACCCTATCCCACCTGAGCTGACCAGGCTCCTGCAGCAATCCCAGGACCCCCTGCTCATGGGGCTGTTTCCTACTAACCCCAAA
GAGAAGACCCAGGAGGAACCCCCTGGCCAGAGCAGGGCCCCTGTGTTGACCGTGGTGTCCAAGTTCAAGGCCTCACTGGAGCAGCTTCTG
CAGGTCCTACACAGCACCACGCCCCACTACATTCGCTGCATCAAGCCCAACAGCCAGGGCCAGGCGCAGACCTTTCTCCAAGAGGAGGTC
CTGAGCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTTCCCCATCCGGGTCTCTCACCGAAACTTTGTA
GAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCATATCCTGCCAAAGGGCTCCCTGAATGGTGT
CCACACAGCGAGGAAGCCACGCTTGAACCTCTCATCCAGGACATTCTCCACACTCTGCCGGTCCTAACTCAGGCAGCAGCCATAACTGGT
GACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGCAGGACCAAGGTGTTCATGACTGACTCTATGCTGGAGCTTCTGGAATGTGGG
CGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGAGGCGACACCGGCACCGAGAGCAGGAGCGGCAGTGGCGGGCC
GTCATGCTCATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCTGCATGCAGCTGCCACAGTCATCAAGCGTGCA
TGGCAGAAGTGGAGAATCAGAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAAGAAAAACACTTCTCTCAAGCTCCCTGTTCC
CTGAGCACCTCGCCGCTGCAGACCAGGCTCCTGGAGGCAATAATCCGCCTCTGGCCCCTGGGACTGGTCCTGGCCAATACGGCTATGGGT
GTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGCCTCCAGCTCCCCAGGGGCAGCCCCAGTAGCTACACTGTCCAGACAGCACAA
GACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAAAGTTTCACTGCAGAAAGTCTCCACTGCGGTATGCTGACATC
TGCCCTGAACCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACACAGGCTGATCCACGTGACCTCTTCTGCCTTC
ACTGGGCTGGGGTGATCCTTGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCCTTGCCAAAGACATTTAATCAGCACACAGCT
GCCAGACTATTCCCACAGTGCTCCAAATGCACATGAACAACAGTGACGGCTCCAGCCTTCGACCCAGAGCCCCGTGCCCAGTGCGTCAGT
GGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGTCAGGGCTGGTAGTTACCAAATCAGGGTTAAGAAACATCAGGGCCACATTTC
ACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTACACTGGGGATCCCAATTCCACATAAGCACTTTTGGAAGAAA
ACAGCCAAAGTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTTATTTCCTTTAAAAAGGAACAAAACTTTAGTA
TTTAATTAGTTGATTTATTTAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGTACAGTAGAATCACGTTTTGATTTTATTAAC
ACTGACCAAGTTTAACTCCATATGAAGTGTAAGCTTGATATCGTTTATGATGTCTATCAACTGTACCAAAAGTAAAACATTTAAAAACAA

>8563_8563_4_AXIN1-MYO19_AXIN1_chr16_354304_ENST00000354866_MYO19_chr17_34867294_ENST00000431794_length(amino acids)=1139AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMVLAGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAE
CDTRRDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEW
SFINYQDNQPCLDLIEGSPISICSLINEECRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPI
PPELTRLLQQSQDPLLMGLFPTNPKEKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLE
ACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEA
MPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWR
IRMACLAAKELDGVEEKHFSQAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQDQAGV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AXIN1-MYO19

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000262320	-	5	11	209_338	418.0	863.0	TP53
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000354866	-	5	10	209_338	418.0	827.0	TP53

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000262320	-	5	11	434_502	418.0	863.0	CTNNB1
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000354866	-	5	10	434_502	418.0	827.0	CTNNB1
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000262320	-	5	11	348_433	418.0	863.0	GSK3B
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000354866	-	5	10	348_433	418.0	827.0	GSK3B
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000262320	-	5	11	677_752	418.0	863.0	HIPK2
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000354866	-	5	10	677_752	418.0	827.0	HIPK2
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000262320	-	5	11	575_789	418.0	863.0	PPP2CA
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000354866	-	5	10	575_789	418.0	827.0	PPP2CA
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000262320	-	5	11	507_757	418.0	863.0	RNF111
Hgene	AXIN1	chr16:354304	chr17:34867294	ENST00000354866	-	5	10	507_757	418.0	827.0	RNF111

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AXIN1-MYO19

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AXIN1-MYO19

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source