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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPECC1L-RET (FusionGDB2 ID:85687)

Fusion Gene Summary for SPECC1L-RET

check button Fusion gene summary
Fusion gene informationFusion gene name: SPECC1L-RET
Fusion gene ID: 85687
HgeneTgene
Gene symbol

SPECC1L

RET

Gene ID

23384

5979

Gene namesperm antigen with calponin homology and coiled-coil domains 1 likeret proto-oncogene
SynonymsCYTSA|GBBB2|OBLFC1|TBHSCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

22q11.23

10q11.21

Type of geneprotein-codingprotein-coding
Descriptioncytospin-ASPECC1-like proteincytokinesis and spindle organization Arenal carcinoma antigen NY-REN-22proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc.

RTL1

Ensembl transtripts involved in fusion geneENST00000314328, ENST00000437398, 
ENST00000541492, ENST00000416735, 
ENST00000340058, ENST00000355710, 
Fusion gene scores* DoF score24 X 9 X 16=345632 X 31 X 11=10912
# samples 3748
** MAII scorelog2(37/3456*10)=-3.22350604164716
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPECC1L [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPECC1L(24734445)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPECC1L

GO:0007155

cell adhesion

21703590

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across SPECC1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-CE-A485-01ASPECC1Lchr22

24734445

-RETchr10

43612032

+
ChimerDB4THCATCGA-CE-A485-01ASPECC1Lchr22

24734445

+RETchr10

43612032

+


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Fusion Gene ORF analysis for SPECC1L-RET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314328ENST00000340058SPECC1Lchr22

24734445

+RETchr10

43612032

+
In-frameENST00000314328ENST00000355710SPECC1Lchr22

24734445

+RETchr10

43612032

+
In-frameENST00000437398ENST00000340058SPECC1Lchr22

24734445

+RETchr10

43612032

+
In-frameENST00000437398ENST00000355710SPECC1Lchr22

24734445

+RETchr10

43612032

+
In-frameENST00000541492ENST00000340058SPECC1Lchr22

24734445

+RETchr10

43612032

+
In-frameENST00000541492ENST00000355710SPECC1Lchr22

24734445

+RETchr10

43612032

+
intron-3CDSENST00000416735ENST00000340058SPECC1Lchr22

24734445

+RETchr10

43612032

+
intron-3CDSENST00000416735ENST00000355710SPECC1Lchr22

24734445

+RETchr10

43612032

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437398SPECC1Lchr2224734445+ENST00000355710RETchr1043612032+614628559540631322
ENST00000437398SPECC1Lchr2224734445+ENST00000340058RETchr1043612032+468828559539371280
ENST00000314328SPECC1Lchr2224734445+ENST00000355710RETchr1043612032+6228293728541451286
ENST00000314328SPECC1Lchr2224734445+ENST00000340058RETchr1043612032+4770293728540191244
ENST00000541492SPECC1Lchr2224734445+ENST00000355710RETchr1043612032+608127903039981322
ENST00000541492SPECC1Lchr2224734445+ENST00000340058RETchr1043612032+462327903038721280

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437398ENST00000355710SPECC1Lchr2224734445+RETchr1043612032+0.0013590920.99864095
ENST00000437398ENST00000340058SPECC1Lchr2224734445+RETchr1043612032+0.0040130680.9959869
ENST00000314328ENST00000355710SPECC1Lchr2224734445+RETchr1043612032+0.0014882680.99851173
ENST00000314328ENST00000340058SPECC1Lchr2224734445+RETchr1043612032+0.004237640.9957624
ENST00000541492ENST00000355710SPECC1Lchr2224734445+RETchr1043612032+0.0012436460.9987564
ENST00000541492ENST00000340058SPECC1Lchr2224734445+RETchr1043612032+0.0037501780.99624985

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Fusion Genomic Features for SPECC1L-RET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPECC1Lchr2224734445+RETchr1043612031+4.60E-070.9999995
SPECC1Lchr2224734445+RETchr1043612031+4.60E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPECC1L-RET


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24734445/chr10:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RET

RTL1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000314328+1017168_2808841118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000314328+1017394_4498841118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000314328+1017487_8078841118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000437398+916168_2808841118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000437398+916394_4498841118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000437398+916487_8078841118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000541492+915168_2808841079.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000541492+915394_4498841079.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000541492+915487_8078841079.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000314328+1017858_8618841118.0Compositional biasNote=Poly-Ala
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000437398+916858_8618841118.0Compositional biasNote=Poly-Ala
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000541492+915858_8618841079.0Compositional biasNote=Poly-Ala
TgeneRETchr22:24734445chr10:43612032ENST000003400581019724_10167121073.0DomainProtein kinase
TgeneRETchr22:24734445chr10:43612032ENST000003557101020724_10167121115.0DomainProtein kinase
TgeneRETchr22:24734445chr10:43612032ENST000003400581019730_7387121073.0Nucleotide bindingATP
TgeneRETchr22:24734445chr10:43612032ENST000003557101020730_7387121115.0Nucleotide bindingATP
TgeneRETchr22:24734445chr10:43612032ENST000003400581019805_8077121073.0RegionNote=Inhibitors binding
TgeneRETchr22:24734445chr10:43612032ENST000003557101020805_8077121115.0RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000314328+10171011_11168841118.0DomainCalponin-homology (CH)
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000437398+9161011_11168841118.0DomainCalponin-homology (CH)
HgeneSPECC1Lchr22:24734445chr10:43612032ENST00000541492+9151011_11168841079.0DomainCalponin-homology (CH)
TgeneRETchr22:24734445chr10:43612032ENST000003400581019168_2727121073.0DomainCadherin
TgeneRETchr22:24734445chr10:43612032ENST000003557101020168_2727121115.0DomainCadherin
TgeneRETchr22:24734445chr10:43612032ENST00000340058101929_6357121073.0Topological domainExtracellular
TgeneRETchr22:24734445chr10:43612032ENST000003400581019658_11147121073.0Topological domainCytoplasmic
TgeneRETchr22:24734445chr10:43612032ENST00000355710102029_6357121115.0Topological domainExtracellular
TgeneRETchr22:24734445chr10:43612032ENST000003557101020658_11147121115.0Topological domainCytoplasmic
TgeneRETchr22:24734445chr10:43612032ENST000003400581019636_6577121073.0TransmembraneHelical
TgeneRETchr22:24734445chr10:43612032ENST000003557101020636_6577121115.0TransmembraneHelical


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Fusion Gene Sequence for SPECC1L-RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85687_85687_1_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000314328_RET_chr10_43612032_ENST00000340058_length(transcript)=4770nt_BP=2937nt
GGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAG
CTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGTGTTCTTGGGGAAGATCCCGACTAAGCCATTTTCCA
GTGGCACCTCTTCCATCATGAGTTCCTGAGGCAGTCCGATGGGGCTACTTTATTCCAGAACAATCACAATTTGCTTGTAAATGCATCACG
AAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAGCAGAAAAA
ATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCAAGAGCAGT
GATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAGCACCTTCA
GCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTTCTACAGGT
AATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTCAGGGAGCT
AATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACAATCAGATC
AGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGAGAAATGAA
CTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGGCTCACCAG
CCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATGAAAACAGA
ATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGTCCCTGAGC
CCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTC
TTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCTACCAGCCC
CTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGC
GGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGGAACTCCAG
GCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGGTTATTCTG
ATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGCATCACATT
TCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCCGTTTTGAA
CGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAATGATAGGG
GCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAGAGGAATAC
AAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGCTGTATTCT
ATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGGCTAGTAGC
TTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAGCCTTCCAA
GAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAAGGAGTGAC
ATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTGATCTAGAG
AATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAATCTGCGGAA
TGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTGATCTAAAG
CGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGC
CGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGACTTCCTCA
GAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTCCTCGAACG
CCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAAC
TTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACC
ACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAAC
CACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGG
GGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAG
CGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGG
GACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGAT
TCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGAT
GTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTT
CTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGAC
AAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCA
TCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCT
TCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCT
CTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATC
CAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATG
GTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAG
TACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTG
GGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGC
CTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTG
TTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACA
TGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACTAGAAATTT

>85687_85687_1_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000314328_RET_chr10_43612032_ENST00000340058_length(amino acids)=1244AA_BP=884
MKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPA
MTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAA
LEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDR
LNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD
DALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLC
QQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKER
SHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL
AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKK
LQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNY
MNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF

--------------------------------------------------------------
>85687_85687_2_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000314328_RET_chr10_43612032_ENST00000355710_length(transcript)=6228nt_BP=2937nt
GGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAG
CTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGTGTTCTTGGGGAAGATCCCGACTAAGCCATTTTCCA
GTGGCACCTCTTCCATCATGAGTTCCTGAGGCAGTCCGATGGGGCTACTTTATTCCAGAACAATCACAATTTGCTTGTAAATGCATCACG
AAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAGCAGAAAAA
ATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCAAGAGCAGT
GATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAGCACCTTCA
GCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTTCTACAGGT
AATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTCAGGGAGCT
AATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACAATCAGATC
AGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGAGAAATGAA
CTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGGCTCACCAG
CCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATGAAAACAGA
ATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGTCCCTGAGC
CCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTC
TTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCTACCAGCCC
CTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGC
GGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGGAACTCCAG
GCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGGTTATTCTG
ATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGCATCACATT
TCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCCGTTTTGAA
CGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAATGATAGGG
GCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAGAGGAATAC
AAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGCTGTATTCT
ATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGGCTAGTAGC
TTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAGCCTTCCAA
GAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAAGGAGTGAC
ATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTGATCTAGAG
AATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAATCTGCGGAA
TGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTGATCTAAAG
CGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGC
CGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGACTTCCTCA
GAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTCCTCGAACG
CCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAAC
TTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACC
ACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAAC
CACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGG
GGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAG
CGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGG
GACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGAT
TCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGAT
GTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTT
CTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGAC
AAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCA
TCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCT
TCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACT
AACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGAT
AGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACG
TCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAG
CCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGC
AGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAA
TTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGA
AAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGA
GGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAA
GACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTAT
CAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATG
AGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTG
CAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAAT
CTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACA
ATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGC
TGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCAC
AACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGA
GTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGG
CATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACAC
CCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTA
CAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAA
ATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCC
AGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAG
CTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAA
TTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAATA

>85687_85687_2_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000314328_RET_chr10_43612032_ENST00000355710_length(amino acids)=1286AA_BP=884
MKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPA
MTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAA
LEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDR
LNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD
DALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLC
QQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKER
SHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL
AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKK
LQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNY
MNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQEDPKWEFPRKNLVLGK
TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE
SRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR
SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF
ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP

--------------------------------------------------------------
>85687_85687_3_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000437398_RET_chr10_43612032_ENST00000340058_length(transcript)=4688nt_BP=2855nt
GGCCAAGGGCGGGGCCCGCGAGGGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGT
CTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGATTTGCTTGTAAAT
GCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAG
CAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCA
AGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAG
CACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTT
CTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTC
AGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACA
ATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGA
GAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGG
CTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATG
AAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGT
CCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGG
AGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCT
ACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGG
GGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGG
AACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGG
TTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGC
ATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCC
GTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAA
TGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAG
AGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGC
TGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGG
CTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAG
CCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAA
GGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTG
ATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAAT
CTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTG
ATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGG
AGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGA
CTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTC
CTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGGAGGATCCAAAGTGGGAATTCCCTC
GGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAG
GGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGC
AGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCT
CCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACC
CGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCG
TTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATG
AAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGC
AAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCT
TCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGG
AGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGT
CCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAG
CCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTA
TCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGAC
TTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAAC
TTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCA
AGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGC
CTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACT
GGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCC
CACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTG
AAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACT

>85687_85687_3_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000437398_RET_chr10_43612032_ENST00000340058_length(amino acids)=1280AA_BP=920
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

--------------------------------------------------------------
>85687_85687_4_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000437398_RET_chr10_43612032_ENST00000355710_length(transcript)=6146nt_BP=2855nt
GGCCAAGGGCGGGGCCCGCGAGGGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGT
CTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGATTTGCTTGTAAAT
GCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAG
CAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCA
AGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAG
CACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTT
CTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTC
AGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACA
ATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGA
GAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGG
CTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATG
AAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGT
CCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGG
AGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCT
ACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGG
GGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGG
AACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGG
TTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGC
ATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCC
GTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAA
TGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAG
AGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGC
TGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGG
CTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAG
CCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAA
GGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTG
ATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAAT
CTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTG
ATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGG
AGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGA
CTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTC
CTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGGAGGATCCAAAGTGGGAATTCCCTC
GGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAG
GGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGC
AGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCT
CCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACC
CGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCG
TTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATG
AAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGC
AAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCT
TCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGG
AGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGT
CCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAG
CCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTG
ATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACA
CGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTT
TGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACT
TCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAG
TGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGT
GTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGG
CAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCA
GGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTC
CTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGAT
GGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTAC
CCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCA
CCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTA
ATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTC
TGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAA
TTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCAC
AGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGC
AGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTT
TATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGC
GCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAG
TTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAAC
TTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACA
GCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATC
CTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGT
TATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTG

>85687_85687_4_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000437398_RET_chr10_43612032_ENST00000355710_length(amino acids)=1322AA_BP=920
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

--------------------------------------------------------------
>85687_85687_5_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000541492_RET_chr10_43612032_ENST00000340058_length(transcript)=4623nt_BP=2790nt
TTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGC
GGTGCAGCGCGATTTGCTTGTAAATGCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTG
TCTGCAATAAGTAAAACGCAAACAGCAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGA
ACAGCAGCATCATTGTCAAAGACCAAGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGA
AAGAAAAGCACCTGCCCATCTGCAGCACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACA
GCTTCTTCAACCAAGCGGAGCACTTCTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAG
AGCAAAAAACTACCTTCTGCAGGTCAGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTT
CGTATGAGCAAGTCTAAGTCAGACAATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACC
AAAGACGTAGAAATTTTACATTTGAGAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAA
AAATCTGAGAAGGAAACTATTATGGCTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGT
GAAGAACTCAACCAGCTGAAAAATGAAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAAT
TCTGAAAAACTGTTTGGCTATCAGTCCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTG
GAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAAT
TTAGACAGTGAGTGCAGTGAGGTCTACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATC
CCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAA
GAGAACCAACACAGTACAAGTGAGGAACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAA
AACGAAAGGCTTGGAGAAGAGAAGGTTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAA
TACTTCCGCTCTCTTCTAGATGAGCATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGT
TACATGGACCTCGCTGAGAATGCCCGTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAA
CAAGACAATAAGGAAGCTCAAGAAATGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGA
AAAGCAGCCTTGGCAGCCACGTTAGAGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAG
AATGAAAAGCAGAAAGTGGCAGAGCTGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTG
GACAAAGAAAAAGCAGAGACTTTGGCTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATT
GCTAAGGTAGAGGATGAATACCGAGCCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCA
GACCTGGATGAAAAAGAAACAGAAAGGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAA
CTTCATGACAACCTCATTATTTCTGATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACA
CTCCACAGAAGACTTCGGGAAGAATCTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAA
TCTGAAGCCCAAGAGGAGATTGGTGATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAA
ATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGA
ATGGGACTGAGTAGAAGGTCCTCGACTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTA
CCAAACCCTGCTGCAGCTGCAATTCCTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAG
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTC
TAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGA
ACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAG
TGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAA
TAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAG
AAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGC
CACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCT
GGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTG
CTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTC

>85687_85687_5_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000541492_RET_chr10_43612032_ENST00000340058_length(amino acids)=1280AA_BP=920
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

--------------------------------------------------------------
>85687_85687_6_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000541492_RET_chr10_43612032_ENST00000355710_length(transcript)=6081nt_BP=2790nt
TTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGC
GGTGCAGCGCGATTTGCTTGTAAATGCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTG
TCTGCAATAAGTAAAACGCAAACAGCAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGA
ACAGCAGCATCATTGTCAAAGACCAAGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGA
AAGAAAAGCACCTGCCCATCTGCAGCACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACA
GCTTCTTCAACCAAGCGGAGCACTTCTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAG
AGCAAAAAACTACCTTCTGCAGGTCAGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTT
CGTATGAGCAAGTCTAAGTCAGACAATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACC
AAAGACGTAGAAATTTTACATTTGAGAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAA
AAATCTGAGAAGGAAACTATTATGGCTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGT
GAAGAACTCAACCAGCTGAAAAATGAAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAAT
TCTGAAAAACTGTTTGGCTATCAGTCCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTG
GAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAAT
TTAGACAGTGAGTGCAGTGAGGTCTACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATC
CCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAA
GAGAACCAACACAGTACAAGTGAGGAACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAA
AACGAAAGGCTTGGAGAAGAGAAGGTTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAA
TACTTCCGCTCTCTTCTAGATGAGCATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGT
TACATGGACCTCGCTGAGAATGCCCGTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAA
CAAGACAATAAGGAAGCTCAAGAAATGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGA
AAAGCAGCCTTGGCAGCCACGTTAGAGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAG
AATGAAAAGCAGAAAGTGGCAGAGCTGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTG
GACAAAGAAAAAGCAGAGACTTTGGCTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATT
GCTAAGGTAGAGGATGAATACCGAGCCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCA
GACCTGGATGAAAAAGAAACAGAAAGGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAA
CTTCATGACAACCTCATTATTTCTGATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACA
CTCCACAGAAGACTTCGGGAAGAATCTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAA
TCTGAAGCCCAAGAGGAGATTGGTGATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAA
ATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGA
ATGGGACTGAGTAGAAGGTCCTCGACTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTA
CCAAACCCTGCTGCAGCTGCAATTCCTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAG
GAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACG
GCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTG
CTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTC
ATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGC
CGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATG
CAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGAT
TTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCC
CTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTAT
CCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGC
CTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGG
AGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGAC
TGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAG
AGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCA
CCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGA
ATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTG
TTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAG
TGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGT
GTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAA
ACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCC
TGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGA
TTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGAT
TCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCAC
GTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCT
TTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGA
GCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGA
CAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCAT
GGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCA
TTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGC
TGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAA
ATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTG
TGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGC
TGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTT
ACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGG
AGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTA
TTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACT
GAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAA

>85687_85687_6_SPECC1L-RET_SPECC1L_chr22_24734445_ENST00000541492_RET_chr10_43612032_ENST00000355710_length(amino acids)=1322AA_BP=920
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV
NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN
LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL

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Fusion Gene PPI Analysis for SPECC1L-RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPECC1L-RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPECC1L-RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource