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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SPECC1L-SQLE (FusionGDB2 ID:85690)

Fusion Gene Summary for SPECC1L-SQLE

Fusion gene summary

Fusion gene information	Fusion gene name: SPECC1L-SQLE
	Fusion gene ID: 85690
		Hgene	Tgene
	Gene symbol	SPECC1L	SQLE
	Gene ID	23384	6713
	Gene name	sperm antigen with calponin homology and coiled-coil domains 1 like	squalene epoxidase
	Synonyms	CYTSA\|GBBB2\|OBLFC1\|TBHS	-
	Cytomap	22q11.23	8q24.13
	Type of gene	protein-coding	protein-coding
	Description	cytospin-ASPECC1-like proteincytokinesis and spindle organization Arenal carcinoma antigen NY-REN-22	squalene monooxygenaseSE
	Modification date	20200313	20200322
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000314328, ENST00000437398, ENST00000541492, ENST00000416735,	ENST00000265896, ENST00000523430,
Fusion gene scores	* DoF score	24 X 9 X 16=3456	3 X 3 X 2=18
	# samples	37	3
	** MAII score	log2(37/3456*10)=-3.22350604164716 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SPECC1L [Title/Abstract] AND SQLE [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SPECC1L(24765288)-SQLE(126015418), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SPECC1L	GO:0007155	cell adhesion	21703590
Tgene	SQLE	GO:0016126	sterol biosynthetic process	30626872

Fusion gene breakpoints across SPECC1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SQLE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-FS-A1ZK-06A	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+

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Fusion Gene ORF analysis for SPECC1L-SQLE

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000314328	ENST00000265896	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+
In-frame	ENST00000314328	ENST00000523430	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+
In-frame	ENST00000437398	ENST00000265896	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+
In-frame	ENST00000437398	ENST00000523430	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+
In-frame	ENST00000541492	ENST00000265896	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+
In-frame	ENST00000541492	ENST00000523430	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+
intron-3CDS	ENST00000416735	ENST00000265896	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+
intron-3CDS	ENST00000416735	ENST00000523430	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000437398	SPECC1L	chr22	24765288	+	ENST00000523430	SQLE	chr8	126015418	+	5060	3290	95	4723	1542
ENST00000437398	SPECC1L	chr22	24765288	+	ENST00000265896	SQLE	chr8	126015418	+	5062	3290	95	4723	1542
ENST00000314328	SPECC1L	chr22	24765288	+	ENST00000523430	SQLE	chr8	126015418	+	5142	3372	285	4805	1506
ENST00000314328	SPECC1L	chr22	24765288	+	ENST00000265896	SQLE	chr8	126015418	+	5144	3372	285	4805	1506
ENST00000541492	SPECC1L	chr22	24765288	+	ENST00000523430	SQLE	chr8	126015418	+	4995	3225	30	4658	1542
ENST00000541492	SPECC1L	chr22	24765288	+	ENST00000265896	SQLE	chr8	126015418	+	4997	3225	30	4658	1542

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000437398	ENST00000523430	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+	0.001117516	0.9988825
ENST00000437398	ENST00000265896	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+	0.001129624	0.9988703
ENST00000314328	ENST00000523430	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+	0.001220912	0.9987791
ENST00000314328	ENST00000265896	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+	0.001233561	0.9987664
ENST00000541492	ENST00000523430	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+	0.001025686	0.9989743
ENST00000541492	ENST00000265896	SPECC1L	chr22	24765288	+	SQLE	chr8	126015418	+	0.001036896	0.9989631

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Fusion Genomic Features for SPECC1L-SQLE

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SPECC1L	chr22	24765288	+	SQLE	chr8	126015417	+	5.29E-05	0.9999471
SPECC1L	chr22	24765288	+	SQLE	chr8	126015417	+	5.29E-05	0.9999471

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPECC1L-SQLE

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24765288/chr8:126015418)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000314328

168_280

1029

1118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000314328

394_449

1029

1118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000314328

487_807

1029

1118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000437398

168_280

1029

1118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000437398

394_449

1029

1118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000437398

487_807

1029

1118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000541492

168_280

1029

1079.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000541492

394_449

1029

1079.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000541492

487_807

1029

1079.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000314328

858_861

1029

1118.0

Compositional bias

Note=Poly-Ala

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000437398

858_861

1029

1118.0

Compositional bias

Note=Poly-Ala

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000541492

858_861

1029

1079.0

Compositional bias

Note=Poly-Ala

Tgene

SQLE

chr22:24765288

chr8:126015418

ENST00000265896

133_134

575.0

Nucleotide binding

FAD

Tgene

SQLE

chr22:24765288

chr8:126015418

ENST00000265896

153_154

575.0

Nucleotide binding

FAD

Tgene

SQLE

chr22:24765288

chr8:126015418

ENST00000265896

118_574

575.0

Region

Sufficient for enzyme activity

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000314328

1011_1116

1029

1118.0

Domain

Calponin-homology (CH)

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000437398

1011_1116

1029

1118.0

Domain

Calponin-homology (CH)

Hgene

SPECC1L

chr22:24765288

chr8:126015418

ENST00000541492

1011_1116

1029

1079.0

Domain

Calponin-homology (CH)

Tgene

SQLE

chr22:24765288

chr8:126015418

ENST00000265896

21_41

575.0

Intramembrane

Ontology_term=ECO:0000305

Tgene

SQLE

chr22:24765288

chr8:126015418

ENST00000265896

1_20

575.0

Topological domain

Cytoplasmic

Tgene

SQLE

chr22:24765288

chr8:126015418

ENST00000265896

42_574

575.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for SPECC1L-SQLE

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>85690_85690_1_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000314328_SQLE_chr8_126015418_ENST00000265896_length(transcript)=5144nt_BP=3372nt
GGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAG
CTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGTGTTCTTGGGGAAGATCCCGACTAAGCCATTTTCCA
GTGGCACCTCTTCCATCATGAGTTCCTGAGGCAGTCCGATGGGGCTACTTTATTCCAGAACAATCACAATTTGCTTGTAAATGCATCACG
AAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAGCAGAAAAA
ATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCAAGAGCAGT
GATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAGCACCTTCA
GCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTTCTACAGGT
AATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTCAGGGAGCT
AATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACAATCAGATC
AGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGAGAAATGAA
CTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGGCTCACCAG
CCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATGAAAACAGA
ATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGTCCCTGAGC
CCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTC
TTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCTACCAGCCC
CTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGC
GGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGGAACTCCAG
GCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGGTTATTCTG
ATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGCATCACATT
TCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCCGTTTTGAA
CGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAATGATAGGG
GCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAGAGGAATAC
AAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGCTGTATTCT
ATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGGCTAGTAGC
TTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAGCCTTCCAA
GAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAAGGAGTGAC
ATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTGATCTAGAG
AATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAATCTGCGGAA
TGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTGATCTAAAG
CGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGC
CGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGACTTCCTCA
GAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTCCTCGAACG
CCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGAGACATTCCATAAGTGGACCAATCTCAACATCC
AAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAAGAGCATCTGTTAAGAACATCTTCAGCCAGCCGG
CCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCTCGACGAAGTAGTGAAGAAGTGAAACGGGACATT
TCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCACAGCTTTCCCTGTCCTCTTCTCCAACGGCATCT
GTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCATTGGCCAGAGAATATGGAGGATCAAAGAGGAAC
GCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGCGCAGAAAAGGAACCAATATTTCAGAAACAAGCTTAATAGGAACAGCT
GCCTGTACATCAACATCTTCTCAGAATGACCCAGAAGTTATCATCGTGGGAGCTGGCGTGCTTGGCTCTGCTTTGGCAGCTGTGCTTTCC
AGAGATGGAAGAAAGGTGACAGTCATTGAGAGAGACTTAAAAGAGCCTGACAGAATAGTTGGAGAATTCCTGCAGCCGGGTGGTTATCAT
GTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGTCTTGATGCCCAGGTTGTAAATGGTTACATGATTCATGATCAGGAAAGCAAA
TCAGAGGTTCAGATTCCTTACCCTCTGTCAGAAAACAATCAAGTGCAGAGTGGAAGAGCTTTCCATCACGGAAGATTCATCATGAGTCTC
CGGAAAGCAGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTGTTACAGTTATTAGAGGAAGATGATGTTGTGATGGGAGTT
CAGTACAAGGATAAAGAGACTGGAGATATCAAGGAACTCCATGCTCCACTGACTGTTGTTGCAGATGGGCTTTTCTCCAAGTTCAGGAAA
AGCCTGGTCTCCAATAAAGTTTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAGAATGCACCACAGTTTAAAGCAAATCATGCTGAA
CTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACTCGAGTACTTGTTGACATTAGAGGAGAAATGCCA
AGGAATTTAAGAGAATACATGGTTGAAAAAATTTACCCACAAATACCTGATCACCTGAAAGAACCATTCTTAGAAGCCACTGACAATTCT
CATCTGAGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGAAACGAGGTGTTCTTCTTTTGGGAGACGCATATAATATGAGG
CATCCACTTACTGGTGGAGGAATGACTGTTGCTTTTAAAGATATAAAACTATGGAGAAAACTGCTAAAGGGTATCCCTGACCTTTATGAT
GATGCAGCTATTTTCGAGGCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCATTCCTTTGTCGTGAATATCCTTGCTCAGGCTCTT
TATGAATTATTTTCTGCCACAGATGATTCCCTGCATCAACTAAGAAAAGCCTGTTTTCTTTATTTCAAACTTGGTGGCGAATGTGTTGCG
GGTCCTGTTGGGCTGCTTTCTGTATTGTCTCCTAACCCTCTAGTTTTAATTGGACACTTCTTTGCTGTTGCAATCTATGCCGTGTATTTT
TGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAGTAGTGGTGCTGTATTGTACAAAGCGTGTTCTGTAATATTTCCT
CTAATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTTAAAGGGGAACCATTTGTGAATGAATATTTGGAACTTACCAAGTCCTAAGA
GACTTTTGGAAGAGGATATATATAGCATAGTACCATACCACTTATAAAGTGGAAACTCTTGGACCAAGATTTGGATTAATTTGTTTTTGA
AGTTTTTTGTATATAAATATGTAAATACATGCTTTAATTTGCAATTTAAAATGAAGGGGTTAAATAAGTTAGACATTTAAAAGAAATGAT
TGTTACCATAAATTAGTGCTAATGCTGAGGAGAACTACAGTTTTTCTTTTGAATTTAGTATTTGAGATGAGTTGTTGGGACATGCAAATA

>85690_85690_1_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000314328_SQLE_chr8_126015418_ENST00000265896_length(amino acids)=1506AA_BP=1028
MKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPA
MTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAA
LEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDR
LNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD
DALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLC
QQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKER
SHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL
AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKK
LQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNY
MNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTA
LSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTTSPQLSLSSSPTASVTPTT
RSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRK
VTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAM
AEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILAN
PSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTG
GGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGL

--------------------------------------------------------------
>85690_85690_2_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000314328_SQLE_chr8_126015418_ENST00000523430_length(transcript)=5142nt_BP=3372nt
GGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAG
CTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGTGTTCTTGGGGAAGATCCCGACTAAGCCATTTTCCA
GTGGCACCTCTTCCATCATGAGTTCCTGAGGCAGTCCGATGGGGCTACTTTATTCCAGAACAATCACAATTTGCTTGTAAATGCATCACG
AAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAGCAGAAAAA
ATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCAAGAGCAGT
GATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAGCACCTTCA
GCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTTCTACAGGT
AATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTCAGGGAGCT
AATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACAATCAGATC
AGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGAGAAATGAA
CTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGGCTCACCAG
CCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATGAAAACAGA
ATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGTCCCTGAGC
CCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTC
TTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCTACCAGCCC
CTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGC
GGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGGAACTCCAG
GCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGGTTATTCTG
ATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGCATCACATT
TCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCCGTTTTGAA
CGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAATGATAGGG
GCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAGAGGAATAC
AAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGCTGTATTCT
ATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGGCTAGTAGC
TTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAGCCTTCCAA
GAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAAGGAGTGAC
ATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTGATCTAGAG
AATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAATCTGCGGAA
TGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTGATCTAAAG
CGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGC
CGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGACTTCCTCA
GAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTCCTCGAACG
CCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGAGACATTCCATAAGTGGACCAATCTCAACATCC
AAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAAGAGCATCTGTTAAGAACATCTTCAGCCAGCCGG
CCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCTCGACGAAGTAGTGAAGAAGTGAAACGGGACATT
TCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCACAGCTTTCCCTGTCCTCTTCTCCAACGGCATCT
GTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCATTGGCCAGAGAATATGGAGGATCAAAGAGGAAC
GCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGCGCAGAAAAGGAACCAATATTTCAGAAACAAGCTTAATAGGAACAGCT
GCCTGTACATCAACATCTTCTCAGAATGACCCAGAAGTTATCATCGTGGGAGCTGGCGTGCTTGGCTCTGCTTTGGCAGCTGTGCTTTCC
AGAGATGGAAGAAAGGTGACAGTCATTGAGAGAGACTTAAAAGAGCCTGACAGAATAGTTGGAGAATTCCTGCAGCCGGGTGGTTATCAT
GTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGTCTTGATGCCCAGGTTGTAAATGGTTACATGATTCATGATCAGGAAAGCAAA
TCAGAGGTTCAGATTCCTTACCCTCTGTCAGAAAACAATCAAGTGCAGAGTGGAAGAGCTTTCCATCACGGAAGATTCATCATGAGTCTC
CGGAAAGCAGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTGTTACAGTTATTAGAGGAAGATGATGTTGTGATGGGAGTT
CAGTACAAGGATAAAGAGACTGGAGATATCAAGGAACTCCATGCTCCACTGACTGTTGTTGCAGATGGGCTTTTCTCCAAGTTCAGGAAA
AGCCTGGTCTCCAATAAAGTTTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAGAATGCACCACAGTTTAAAGCAAATCATGCTGAA
CTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACTCGAGTACTTGTTGACATTAGAGGAGAAATGCCA
AGGAATTTAAGAGAATACATGGTTGAAAAAATTTACCCACAAATACCTGATCACCTGAAAGAACCATTCTTAGAAGCCACTGACAATTCT
CATCTGAGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGAAACGAGGTGTTCTTCTTTTGGGAGACGCATATAATATGAGG
CATCCACTTACTGGTGGAGGAATGACTGTTGCTTTTAAAGATATAAAACTATGGAGAAAACTGCTAAAGGGTATCCCTGACCTTTATGAT
GATGCAGCTATTTTCGAGGCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCATTCCTTTGTCGTGAATATCCTTGCTCAGGCTCTT
TATGAATTATTTTCTGCCACAGATGATTCCCTGCATCAACTAAGAAAAGCCTGTTTTCTTTATTTCAAACTTGGTGGCGAATGTGTTGCG
GGTCCTGTTGGGCTGCTTTCTGTATTGTCTCCTAACCCTCTAGTTTTAATTGGACACTTCTTTGCTGTTGCAATCTATGCCGTGTATTTT
TGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAGTAGTGGTGCTGTATTGTACAAAGCGTGTTCTGTAATATTTCCT
CTAATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTTAAAGGGGAACCATTTGTGAATGAATATTTGGAACTTACCAAGTCCTAAGA
GACTTTTGGAAGAGGATATATATAGCATAGTACCATACCACTTATAAAGTGGAAACTCTTGGACCAAGATTTGGATTAATTTGTTTTTGA
AGTTTTTTGTATATAAATATGTAAATACATGCTTTAATTTGCAATTTAAAATGAAGGGGTTAAATAAGTTAGACATTTAAAAGAAATGAT
TGTTACCATAAATTAGTGCTAATGCTGAGGAGAACTACAGTTTTTCTTTTGAATTTAGTATTTGAGATGAGTTGTTGGGACATGCAAATA

>85690_85690_2_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000314328_SQLE_chr8_126015418_ENST00000523430_length(amino acids)=1506AA_BP=1028
MKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPA
MTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAA
LEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDR
LNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD
DALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLC
QQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKER
SHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL
AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKK
LQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNY
MNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTA
LSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTTSPQLSLSSSPTASVTPTT
RSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRK
VTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAM
AEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILAN
PSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTG
GGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGL

--------------------------------------------------------------
>85690_85690_3_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000437398_SQLE_chr8_126015418_ENST00000265896_length(transcript)=5062nt_BP=3290nt
GGCCAAGGGCGGGGCCCGCGAGGGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGT
CTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGATTTGCTTGTAAAT
GCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAG
CAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCA
AGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAG
CACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTT
CTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTC
AGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACA
ATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGA
GAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGG
CTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATG
AAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGT
CCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGG
AGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCT
ACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGG
GGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGG
AACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGG
TTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGC
ATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCC
GTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAA
TGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAG
AGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGC
TGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGG
CTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAG
CCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAA
GGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTG
ATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAAT
CTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTG
ATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGG
AGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGA
CTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTC
CTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGAGACATTCCATAAGTGGACCAATCT
CAACATCCAAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAAGAGCATCTGTTAAGAACATCTTCAG
CCAGCCGGCCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCTCGACGAAGTAGTGAAGAAGTGAAAC
GGGACATTTCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCACAGCTTTCCCTGTCCTCTTCTCCAA
CGGCATCTGTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCATTGGCCAGAGAATATGGAGGATCAA
AGAGGAACGCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGCGCAGAAAAGGAACCAATATTTCAGAAACAAGCTTAATAG
GAACAGCTGCCTGTACATCAACATCTTCTCAGAATGACCCAGAAGTTATCATCGTGGGAGCTGGCGTGCTTGGCTCTGCTTTGGCAGCTG
TGCTTTCCAGAGATGGAAGAAAGGTGACAGTCATTGAGAGAGACTTAAAAGAGCCTGACAGAATAGTTGGAGAATTCCTGCAGCCGGGTG
GTTATCATGTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGTCTTGATGCCCAGGTTGTAAATGGTTACATGATTCATGATCAGG
AAAGCAAATCAGAGGTTCAGATTCCTTACCCTCTGTCAGAAAACAATCAAGTGCAGAGTGGAAGAGCTTTCCATCACGGAAGATTCATCA
TGAGTCTCCGGAAAGCAGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTGTTACAGTTATTAGAGGAAGATGATGTTGTGA
TGGGAGTTCAGTACAAGGATAAAGAGACTGGAGATATCAAGGAACTCCATGCTCCACTGACTGTTGTTGCAGATGGGCTTTTCTCCAAGT
TCAGGAAAAGCCTGGTCTCCAATAAAGTTTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAGAATGCACCACAGTTTAAAGCAAATC
ATGCTGAACTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACTCGAGTACTTGTTGACATTAGAGGAG
AAATGCCAAGGAATTTAAGAGAATACATGGTTGAAAAAATTTACCCACAAATACCTGATCACCTGAAAGAACCATTCTTAGAAGCCACTG
ACAATTCTCATCTGAGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGAAACGAGGTGTTCTTCTTTTGGGAGACGCATATA
ATATGAGGCATCCACTTACTGGTGGAGGAATGACTGTTGCTTTTAAAGATATAAAACTATGGAGAAAACTGCTAAAGGGTATCCCTGACC
TTTATGATGATGCAGCTATTTTCGAGGCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCATTCCTTTGTCGTGAATATCCTTGCTC
AGGCTCTTTATGAATTATTTTCTGCCACAGATGATTCCCTGCATCAACTAAGAAAAGCCTGTTTTCTTTATTTCAAACTTGGTGGCGAAT
GTGTTGCGGGTCCTGTTGGGCTGCTTTCTGTATTGTCTCCTAACCCTCTAGTTTTAATTGGACACTTCTTTGCTGTTGCAATCTATGCCG
TGTATTTTTGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAGTAGTGGTGCTGTATTGTACAAAGCGTGTTCTGTAA
TATTTCCTCTAATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTTAAAGGGGAACCATTTGTGAATGAATATTTGGAACTTACCAAG
TCCTAAGAGACTTTTGGAAGAGGATATATATAGCATAGTACCATACCACTTATAAAGTGGAAACTCTTGGACCAAGATTTGGATTAATTT
GTTTTTGAAGTTTTTTGTATATAAATATGTAAATACATGCTTTAATTTGCAATTTAAAATGAAGGGGTTAAATAAGTTAGACATTTAAAA
GAAATGATTGTTACCATAAATTAGTGCTAATGCTGAGGAGAACTACAGTTTTTCTTTTGAATTTAGTATTTGAGATGAGTTGTTGGGACA

>85690_85690_3_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000437398_SQLE_chr8_126015418_ENST00000265896_length(amino acids)=1542AA_BP=1064
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRD
ISAQEGASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQRRKGTNISETSLIGT
AACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQES
KSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFR
KSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDN
SHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQA
LYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIF

--------------------------------------------------------------
>85690_85690_4_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000437398_SQLE_chr8_126015418_ENST00000523430_length(transcript)=5060nt_BP=3290nt
GGCCAAGGGCGGGGCCCGCGAGGGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGT
CTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGATTTGCTTGTAAAT
GCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAG
CAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCA
AGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAG
CACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTT
CTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTC
AGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACA
ATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGA
GAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGG
CTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATG
AAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGT
CCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGG
AGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCT
ACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGG
GGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGG
AACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGG
TTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGC
ATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCC
GTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAA
TGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAG
AGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGC
TGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGG
CTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAG
CCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAA
GGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTG
ATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAAT
CTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTG
ATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGG
AGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGA
CTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTC
CTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGAGACATTCCATAAGTGGACCAATCT
CAACATCCAAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAAGAGCATCTGTTAAGAACATCTTCAG
CCAGCCGGCCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCTCGACGAAGTAGTGAAGAAGTGAAAC
GGGACATTTCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCACAGCTTTCCCTGTCCTCTTCTCCAA
CGGCATCTGTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCATTGGCCAGAGAATATGGAGGATCAA
AGAGGAACGCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGCGCAGAAAAGGAACCAATATTTCAGAAACAAGCTTAATAG
GAACAGCTGCCTGTACATCAACATCTTCTCAGAATGACCCAGAAGTTATCATCGTGGGAGCTGGCGTGCTTGGCTCTGCTTTGGCAGCTG
TGCTTTCCAGAGATGGAAGAAAGGTGACAGTCATTGAGAGAGACTTAAAAGAGCCTGACAGAATAGTTGGAGAATTCCTGCAGCCGGGTG
GTTATCATGTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGTCTTGATGCCCAGGTTGTAAATGGTTACATGATTCATGATCAGG
AAAGCAAATCAGAGGTTCAGATTCCTTACCCTCTGTCAGAAAACAATCAAGTGCAGAGTGGAAGAGCTTTCCATCACGGAAGATTCATCA
TGAGTCTCCGGAAAGCAGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTGTTACAGTTATTAGAGGAAGATGATGTTGTGA
TGGGAGTTCAGTACAAGGATAAAGAGACTGGAGATATCAAGGAACTCCATGCTCCACTGACTGTTGTTGCAGATGGGCTTTTCTCCAAGT
TCAGGAAAAGCCTGGTCTCCAATAAAGTTTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAGAATGCACCACAGTTTAAAGCAAATC
ATGCTGAACTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACTCGAGTACTTGTTGACATTAGAGGAG
AAATGCCAAGGAATTTAAGAGAATACATGGTTGAAAAAATTTACCCACAAATACCTGATCACCTGAAAGAACCATTCTTAGAAGCCACTG
ACAATTCTCATCTGAGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGAAACGAGGTGTTCTTCTTTTGGGAGACGCATATA
ATATGAGGCATCCACTTACTGGTGGAGGAATGACTGTTGCTTTTAAAGATATAAAACTATGGAGAAAACTGCTAAAGGGTATCCCTGACC
TTTATGATGATGCAGCTATTTTCGAGGCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCATTCCTTTGTCGTGAATATCCTTGCTC
AGGCTCTTTATGAATTATTTTCTGCCACAGATGATTCCCTGCATCAACTAAGAAAAGCCTGTTTTCTTTATTTCAAACTTGGTGGCGAAT
GTGTTGCGGGTCCTGTTGGGCTGCTTTCTGTATTGTCTCCTAACCCTCTAGTTTTAATTGGACACTTCTTTGCTGTTGCAATCTATGCCG
TGTATTTTTGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAGTAGTGGTGCTGTATTGTACAAAGCGTGTTCTGTAA
TATTTCCTCTAATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTTAAAGGGGAACCATTTGTGAATGAATATTTGGAACTTACCAAG
TCCTAAGAGACTTTTGGAAGAGGATATATATAGCATAGTACCATACCACTTATAAAGTGGAAACTCTTGGACCAAGATTTGGATTAATTT
GTTTTTGAAGTTTTTTGTATATAAATATGTAAATACATGCTTTAATTTGCAATTTAAAATGAAGGGGTTAAATAAGTTAGACATTTAAAA
GAAATGATTGTTACCATAAATTAGTGCTAATGCTGAGGAGAACTACAGTTTTTCTTTTGAATTTAGTATTTGAGATGAGTTGTTGGGACA

>85690_85690_4_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000437398_SQLE_chr8_126015418_ENST00000523430_length(amino acids)=1542AA_BP=1064
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRD
ISAQEGASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQRRKGTNISETSLIGT
AACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQES
KSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFR
KSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDN
SHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQA
LYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIF

--------------------------------------------------------------
>85690_85690_5_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000541492_SQLE_chr8_126015418_ENST00000265896_length(transcript)=4997nt_BP=3225nt
TTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGC
GGTGCAGCGCGATTTGCTTGTAAATGCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTG
TCTGCAATAAGTAAAACGCAAACAGCAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGA
ACAGCAGCATCATTGTCAAAGACCAAGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGA
AAGAAAAGCACCTGCCCATCTGCAGCACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACA
GCTTCTTCAACCAAGCGGAGCACTTCTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAG
AGCAAAAAACTACCTTCTGCAGGTCAGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTT
CGTATGAGCAAGTCTAAGTCAGACAATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACC
AAAGACGTAGAAATTTTACATTTGAGAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAA
AAATCTGAGAAGGAAACTATTATGGCTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGT
GAAGAACTCAACCAGCTGAAAAATGAAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAAT
TCTGAAAAACTGTTTGGCTATCAGTCCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTG
GAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAAT
TTAGACAGTGAGTGCAGTGAGGTCTACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATC
CCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAA
GAGAACCAACACAGTACAAGTGAGGAACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAA
AACGAAAGGCTTGGAGAAGAGAAGGTTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAA
TACTTCCGCTCTCTTCTAGATGAGCATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGT
TACATGGACCTCGCTGAGAATGCCCGTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAA
CAAGACAATAAGGAAGCTCAAGAAATGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGA
AAAGCAGCCTTGGCAGCCACGTTAGAGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAG
AATGAAAAGCAGAAAGTGGCAGAGCTGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTG
GACAAAGAAAAAGCAGAGACTTTGGCTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATT
GCTAAGGTAGAGGATGAATACCGAGCCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCA
GACCTGGATGAAAAAGAAACAGAAAGGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAA
CTTCATGACAACCTCATTATTTCTGATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACA
CTCCACAGAAGACTTCGGGAAGAATCTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAA
TCTGAAGCCCAAGAGGAGATTGGTGATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAA
ATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGA
ATGGGACTGAGTAGAAGGTCCTCGACTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTA
CCAAACCCTGCTGCAGCTGCAATTCCTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAG
AGACATTCCATAAGTGGACCAATCTCAACATCCAAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAA
GAGCATCTGTTAAGAACATCTTCAGCCAGCCGGCCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCT
CGACGAAGTAGTGAAGAAGTGAAACGGGACATTTCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCA
CAGCTTTCCCTGTCCTCTTCTCCAACGGCATCTGTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCA
TTGGCCAGAGAATATGGAGGATCAAAGAGGAACGCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGCGCAGAAAAGGAACC
AATATTTCAGAAACAAGCTTAATAGGAACAGCTGCCTGTACATCAACATCTTCTCAGAATGACCCAGAAGTTATCATCGTGGGAGCTGGC
GTGCTTGGCTCTGCTTTGGCAGCTGTGCTTTCCAGAGATGGAAGAAAGGTGACAGTCATTGAGAGAGACTTAAAAGAGCCTGACAGAATA
GTTGGAGAATTCCTGCAGCCGGGTGGTTATCATGTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGTCTTGATGCCCAGGTTGTA
AATGGTTACATGATTCATGATCAGGAAAGCAAATCAGAGGTTCAGATTCCTTACCCTCTGTCAGAAAACAATCAAGTGCAGAGTGGAAGA
GCTTTCCATCACGGAAGATTCATCATGAGTCTCCGGAAAGCAGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTGTTACAG
TTATTAGAGGAAGATGATGTTGTGATGGGAGTTCAGTACAAGGATAAAGAGACTGGAGATATCAAGGAACTCCATGCTCCACTGACTGTT
GTTGCAGATGGGCTTTTCTCCAAGTTCAGGAAAAGCCTGGTCTCCAATAAAGTTTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAG
AATGCACCACAGTTTAAAGCAAATCATGCTGAACTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACT
CGAGTACTTGTTGACATTAGAGGAGAAATGCCAAGGAATTTAAGAGAATACATGGTTGAAAAAATTTACCCACAAATACCTGATCACCTG
AAAGAACCATTCTTAGAAGCCACTGACAATTCTCATCTGAGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGAAACGAGGT
GTTCTTCTTTTGGGAGACGCATATAATATGAGGCATCCACTTACTGGTGGAGGAATGACTGTTGCTTTTAAAGATATAAAACTATGGAGA
AAACTGCTAAAGGGTATCCCTGACCTTTATGATGATGCAGCTATTTTCGAGGCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCAT
TCCTTTGTCGTGAATATCCTTGCTCAGGCTCTTTATGAATTATTTTCTGCCACAGATGATTCCCTGCATCAACTAAGAAAAGCCTGTTTT
CTTTATTTCAAACTTGGTGGCGAATGTGTTGCGGGTCCTGTTGGGCTGCTTTCTGTATTGTCTCCTAACCCTCTAGTTTTAATTGGACAC
TTCTTTGCTGTTGCAATCTATGCCGTGTATTTTTGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAGTAGTGGTGCT
GTATTGTACAAAGCGTGTTCTGTAATATTTCCTCTAATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTTAAAGGGGAACCATTTGT
GAATGAATATTTGGAACTTACCAAGTCCTAAGAGACTTTTGGAAGAGGATATATATAGCATAGTACCATACCACTTATAAAGTGGAAACT
CTTGGACCAAGATTTGGATTAATTTGTTTTTGAAGTTTTTTGTATATAAATATGTAAATACATGCTTTAATTTGCAATTTAAAATGAAGG
GGTTAAATAAGTTAGACATTTAAAAGAAATGATTGTTACCATAAATTAGTGCTAATGCTGAGGAGAACTACAGTTTTTCTTTTGAATTTA

>85690_85690_5_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000541492_SQLE_chr8_126015418_ENST00000265896_length(amino acids)=1542AA_BP=1064
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRD
ISAQEGASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQRRKGTNISETSLIGT
AACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQES
KSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFR
KSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDN
SHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQA
LYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIF

--------------------------------------------------------------
>85690_85690_6_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000541492_SQLE_chr8_126015418_ENST00000523430_length(transcript)=4995nt_BP=3225nt
TTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGC
GGTGCAGCGCGATTTGCTTGTAAATGCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTG
TCTGCAATAAGTAAAACGCAAACAGCAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGA
ACAGCAGCATCATTGTCAAAGACCAAGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGA
AAGAAAAGCACCTGCCCATCTGCAGCACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACA
GCTTCTTCAACCAAGCGGAGCACTTCTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAG
AGCAAAAAACTACCTTCTGCAGGTCAGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTT
CGTATGAGCAAGTCTAAGTCAGACAATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACC
AAAGACGTAGAAATTTTACATTTGAGAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAA
AAATCTGAGAAGGAAACTATTATGGCTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGT
GAAGAACTCAACCAGCTGAAAAATGAAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAAT
TCTGAAAAACTGTTTGGCTATCAGTCCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTG
GAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAAT
TTAGACAGTGAGTGCAGTGAGGTCTACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATC
CCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAA
GAGAACCAACACAGTACAAGTGAGGAACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAA
AACGAAAGGCTTGGAGAAGAGAAGGTTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAA
TACTTCCGCTCTCTTCTAGATGAGCATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGT
TACATGGACCTCGCTGAGAATGCCCGTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAA
CAAGACAATAAGGAAGCTCAAGAAATGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGA
AAAGCAGCCTTGGCAGCCACGTTAGAGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAG
AATGAAAAGCAGAAAGTGGCAGAGCTGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTG
GACAAAGAAAAAGCAGAGACTTTGGCTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATT
GCTAAGGTAGAGGATGAATACCGAGCCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCA
GACCTGGATGAAAAAGAAACAGAAAGGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAA
CTTCATGACAACCTCATTATTTCTGATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACA
CTCCACAGAAGACTTCGGGAAGAATCTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAA
TCTGAAGCCCAAGAGGAGATTGGTGATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAA
ATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGA
ATGGGACTGAGTAGAAGGTCCTCGACTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTA
CCAAACCCTGCTGCAGCTGCAATTCCTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAG
AGACATTCCATAAGTGGACCAATCTCAACATCCAAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAA
GAGCATCTGTTAAGAACATCTTCAGCCAGCCGGCCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCT
CGACGAAGTAGTGAAGAAGTGAAACGGGACATTTCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCA
CAGCTTTCCCTGTCCTCTTCTCCAACGGCATCTGTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCA
TTGGCCAGAGAATATGGAGGATCAAAGAGGAACGCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGCGCAGAAAAGGAACC
AATATTTCAGAAACAAGCTTAATAGGAACAGCTGCCTGTACATCAACATCTTCTCAGAATGACCCAGAAGTTATCATCGTGGGAGCTGGC
GTGCTTGGCTCTGCTTTGGCAGCTGTGCTTTCCAGAGATGGAAGAAAGGTGACAGTCATTGAGAGAGACTTAAAAGAGCCTGACAGAATA
GTTGGAGAATTCCTGCAGCCGGGTGGTTATCATGTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGTCTTGATGCCCAGGTTGTA
AATGGTTACATGATTCATGATCAGGAAAGCAAATCAGAGGTTCAGATTCCTTACCCTCTGTCAGAAAACAATCAAGTGCAGAGTGGAAGA
GCTTTCCATCACGGAAGATTCATCATGAGTCTCCGGAAAGCAGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTGTTACAG
TTATTAGAGGAAGATGATGTTGTGATGGGAGTTCAGTACAAGGATAAAGAGACTGGAGATATCAAGGAACTCCATGCTCCACTGACTGTT
GTTGCAGATGGGCTTTTCTCCAAGTTCAGGAAAAGCCTGGTCTCCAATAAAGTTTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAG
AATGCACCACAGTTTAAAGCAAATCATGCTGAACTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACT
CGAGTACTTGTTGACATTAGAGGAGAAATGCCAAGGAATTTAAGAGAATACATGGTTGAAAAAATTTACCCACAAATACCTGATCACCTG
AAAGAACCATTCTTAGAAGCCACTGACAATTCTCATCTGAGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGAAACGAGGT
GTTCTTCTTTTGGGAGACGCATATAATATGAGGCATCCACTTACTGGTGGAGGAATGACTGTTGCTTTTAAAGATATAAAACTATGGAGA
AAACTGCTAAAGGGTATCCCTGACCTTTATGATGATGCAGCTATTTTCGAGGCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCAT
TCCTTTGTCGTGAATATCCTTGCTCAGGCTCTTTATGAATTATTTTCTGCCACAGATGATTCCCTGCATCAACTAAGAAAAGCCTGTTTT
CTTTATTTCAAACTTGGTGGCGAATGTGTTGCGGGTCCTGTTGGGCTGCTTTCTGTATTGTCTCCTAACCCTCTAGTTTTAATTGGACAC
TTCTTTGCTGTTGCAATCTATGCCGTGTATTTTTGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAGTAGTGGTGCT
GTATTGTACAAAGCGTGTTCTGTAATATTTCCTCTAATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTTAAAGGGGAACCATTTGT
GAATGAATATTTGGAACTTACCAAGTCCTAAGAGACTTTTGGAAGAGGATATATATAGCATAGTACCATACCACTTATAAAGTGGAAACT
CTTGGACCAAGATTTGGATTAATTTGTTTTTGAAGTTTTTTGTATATAAATATGTAAATACATGCTTTAATTTGCAATTTAAAATGAAGG
GGTTAAATAAGTTAGACATTTAAAAGAAATGATTGTTACCATAAATTAGTGCTAATGCTGAGGAGAACTACAGTTTTTCTTTTGAATTTA

>85690_85690_6_SPECC1L-SQLE_SPECC1L_chr22_24765288_ENST00000541492_SQLE_chr8_126015418_ENST00000523430_length(amino acids)=1542AA_BP=1064
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRD
ISAQEGASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQRRKGTNISETSLIGT
AACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQES
KSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFR
KSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDN
SHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQA
LYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIF

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Fusion Gene PPI Analysis for SPECC1L-SQLE

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SQLE	chr22:24765288	chr8:126015418	ENST00000265896		0	11	1_100	97.0	575.0	MARCHF6

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SPECC1L-SQLE

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SPECC1L-SQLE

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source