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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPECC1L-TM4SF1 (FusionGDB2 ID:85693)

Fusion Gene Summary for SPECC1L-TM4SF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPECC1L-TM4SF1
Fusion gene ID: 85693
HgeneTgene
Gene symbol

SPECC1L

TM4SF1

Gene ID

23384

4071

Gene namesperm antigen with calponin homology and coiled-coil domains 1 liketransmembrane 4 L six family member 1
SynonymsCYTSA|GBBB2|OBLFC1|TBHSH-L6|L6|M3S1|TAAL6
Cytomap

22q11.23

3q25.1

Type of geneprotein-codingprotein-coding
Descriptioncytospin-ASPECC1-like proteincytokinesis and spindle organization Arenal carcinoma antigen NY-REN-22transmembrane 4 L6 family member 1membrane component, chromosome 3, surface marker 1transmembrane 4 superfamily member 1tumor-associated antigen L6
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314328, ENST00000437398, 
ENST00000541492, ENST00000416735, 
ENST00000305366, ENST00000472441, 
Fusion gene scores* DoF score24 X 9 X 16=345610 X 6 X 5=300
# samples 3710
** MAII scorelog2(37/3456*10)=-3.22350604164716
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPECC1L [Title/Abstract] AND TM4SF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPECC1L(24765288)-TM4SF1(149089654), # samples:1
Anticipated loss of major functional domain due to fusion event.SPECC1L-TM4SF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SPECC1L-TM4SF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPECC1L

GO:0007155

cell adhesion

21703590


check buttonFusion gene breakpoints across SPECC1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TM4SF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A1FM-11BSPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-


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Fusion Gene ORF analysis for SPECC1L-TM4SF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000314328ENST00000305366SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-
Frame-shiftENST00000437398ENST00000305366SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-
Frame-shiftENST00000541492ENST00000305366SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-
In-frameENST00000314328ENST00000472441SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-
In-frameENST00000437398ENST00000472441SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-
In-frameENST00000541492ENST00000472441SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-
intron-3CDSENST00000416735ENST00000305366SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-
intron-3CDSENST00000416735ENST00000472441SPECC1Lchr22

24765288

+TM4SF1chr3

149089654

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437398SPECC1Lchr2224765288+ENST00000472441TM4SF1chr3149089654-613532909533281077
ENST00000314328SPECC1Lchr2224765288+ENST00000472441TM4SF1chr3149089654-6217337228534101041
ENST00000541492SPECC1Lchr2224765288+ENST00000472441TM4SF1chr3149089654-607032253032631077

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437398ENST00000472441SPECC1Lchr2224765288+TM4SF1chr3149089654-0.000154340.9998456
ENST00000314328ENST00000472441SPECC1Lchr2224765288+TM4SF1chr3149089654-0.0001667280.9998332
ENST00000541492ENST00000472441SPECC1Lchr2224765288+TM4SF1chr3149089654-0.00014330.9998567

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Fusion Genomic Features for SPECC1L-TM4SF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPECC1L-TM4SF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24765288/chr3:149089654)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000314328+1417168_28010291118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000314328+1417394_44910291118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000314328+1417487_80710291118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000437398+1316168_28010291118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000437398+1316394_44910291118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000437398+1316487_80710291118.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000541492+1315168_28010291079.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000541492+1315394_44910291079.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000541492+1315487_80710291079.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000314328+1417858_86110291118.0Compositional biasNote=Poly-Ala
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000437398+1316858_86110291118.0Compositional biasNote=Poly-Ala
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000541492+1315858_86110291079.0Compositional biasNote=Poly-Ala
TgeneTM4SF1chr22:24765288chr3:149089654ENST0000030536625183_202137203.0Topological domainCytoplasmic
TgeneTM4SF1chr22:24765288chr3:149089654ENST0000030536625162_182137203.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000314328+14171011_111610291118.0DomainCalponin-homology (CH)
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000437398+13161011_111610291118.0DomainCalponin-homology (CH)
HgeneSPECC1Lchr22:24765288chr3:149089654ENST00000541492+13151011_111610291079.0DomainCalponin-homology (CH)
TgeneTM4SF1chr22:24765288chr3:149089654ENST0000030536625115_161137203.0Topological domainExtracellular
TgeneTM4SF1chr22:24765288chr3:149089654ENST00000305366251_9137203.0Topological domainCytoplasmic
TgeneTM4SF1chr22:24765288chr3:149089654ENST000003053662531_49137203.0Topological domainExtracellular
TgeneTM4SF1chr22:24765288chr3:149089654ENST000003053662571_93137203.0Topological domainCytoplasmic
TgeneTM4SF1chr22:24765288chr3:149089654ENST000003053662510_30137203.0TransmembraneHelical
TgeneTM4SF1chr22:24765288chr3:149089654ENST000003053662550_70137203.0TransmembraneHelical
TgeneTM4SF1chr22:24765288chr3:149089654ENST000003053662594_114137203.0TransmembraneHelical


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Fusion Gene Sequence for SPECC1L-TM4SF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85693_85693_1_SPECC1L-TM4SF1_SPECC1L_chr22_24765288_ENST00000314328_TM4SF1_chr3_149089654_ENST00000472441_length(transcript)=6217nt_BP=3372nt
GGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAG
CTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGTGTTCTTGGGGAAGATCCCGACTAAGCCATTTTCCA
GTGGCACCTCTTCCATCATGAGTTCCTGAGGCAGTCCGATGGGGCTACTTTATTCCAGAACAATCACAATTTGCTTGTAAATGCATCACG
AAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAGCAGAAAAA
ATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCAAGAGCAGT
GATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAGCACCTTCA
GCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTTCTACAGGT
AATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTCAGGGAGCT
AATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACAATCAGATC
AGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGAGAAATGAA
CTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGGCTCACCAG
CCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATGAAAACAGA
ATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGTCCCTGAGC
CCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTC
TTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCTACCAGCCC
CTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGC
GGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGGAACTCCAG
GCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGGTTATTCTG
ATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGCATCACATT
TCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCCGTTTTGAA
CGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAATGATAGGG
GCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAGAGGAATAC
AAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGCTGTATTCT
ATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGGCTAGTAGC
TTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAGCCTTCCAA
GAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAAGGAGTGAC
ATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTGATCTAGAG
AATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAATCTGCGGAA
TGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTGATCTAAAG
CGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGC
CGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGACTTCCTCA
GAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTCCTCGAACG
CCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGAGACATTCCATAAGTGGACCAATCTCAACATCC
AAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAAGAGCATCTGTTAAGAACATCTTCAGCCAGCCGG
CCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCTCGACGAAGTAGTGAAGAAGTGAAACGGGACATT
TCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCACAGCTTTCCCTGTCCTCTTCTCCAACGGCATCT
GTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCATTGGCCAGAGAATATGGAGGATCAAAGAGGAAC
GCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGGTACCTTCTGGATACCTCCACATGGTCCGAGTGCACTGAACCCAAGCA
CATTGTGGAATGGAATGTATCTCTGTTTTCTATCCTCTTGGCTCTTGGTGGAATTGAATTCATCTTGTGTCTTATTCAAGTAATAAATGG
AGTGCTTGGAGGCATATGTGGCTTTTGCTGCTCTCACCAACAGGTAAGAACCTGCATGAAAATGTCGTAGTCTGGCCCTGGTGTTAATAT
ACCATTGTTTTCATCATAAAGAAAAAGGCAAAACCAAACATGCTCGACCTACCAGCATTTATTCTGATATCATCTTTGTAGCAACACAAT
TATAGCATTCACTTTAGCTGTCAGTAACAAGCTTCCTCGAGTCTCACAGTCACAGGATTGTCTTAGTTCTTTGCAGTTGGCTCTATGTAC
ACAAGAACATGCTGCCCATAGACACAGCGCTCCCTTCAGGATCTAATTCACTGCCTCTGCTCTCGCTGCAGAGACAGAAAAAAAAGTGAT
GTCTGCTCTTTGTTTGCTGTTATATTCCCAACTAGTATACATAAGTAATAGCCAACCATTCAATGCATCAGGCACTATGCTAAACCCATA
TGACTCAAATATTAAGCAATAGGCTTAAGATCACCTACTCAGGAAATAACAGGCTTCAAACCTTGAGTCGCTCTGTGCAAAAGCTCCTAC
TTTTAACCTGTATTCCACACTTGCTGTTTGGTTGGATTTTCTGCAATTCCTTCCTAATAAGGAGTCATAAAAATGCCTAAGCAGTAAGTA
TGGAGAATCACTAGCAATCTTTGAACAGCAGCTCATGAAAAGCCTTTCGTTGTGAAAGAAAACCAGGAAGCACTTGTTTCCTGGGGATAT
GATTTAGGAGAAAAAAATGCATTTGTTTGTAGCAGTGAAAGTTCTTGTTTCTATATCCTCCTAAAATATATATATTATTGAATTAATGAA
AGTCCAGCTTTGATCCTATCTTTGAGAGGGTTATTTTATGTCTTATATTTTTCAAACCATTTACTCCTCTGGTGCCAGATCTGTTAACTT
TCTTTTAAAAATAAGACAAAAACCTAATGAAAACTGAAAGCCCATTGCTACCATGAAAAACTTTGCTGAAAATAAAAGGAAACTTTCTGT
AATTTTGGGGGAAGGTTAAAATGAAAATCTAGTTTTCCTTATCAGGCAAGTATAGCAAGATTAATAATTTCTTTGGCAAATTTCCAAGAA
AATAAGGGAATGGGAAACCTTCAATATGGAGCTTCTTTCAAGCAGTACGGTTGGGGAAGGGCAGAGAAGTATCCTCTAGGGATTGCTGTC
ATGCAGCTTACCTTTAGCCTTGAATTTCATACAAGGCAGAGTTCAAAGTAAGTGATTACTTGTACTAAATGTACTCACTTAGTACGTTTT
GGGGACAGGCATAAAGAGCCAATGACCAAAATGGCTGAAGTGATTTGGCAGGGAATGATACTCTCCTCTGATTTGGGGTAGTAAATACAC
CAGGTTTCCCAGCTGAGTCACTGTAGGGATGGCTTCTTCCCAGATACTACAGGGAAGATCTGTTACCTTTGTTTATAAGACAAAAGACAC
TTTCAAAGGGCAGGTCTTTTCATGTAGAAGAGTCAGGTCCATAACTCGGTAGCATTTAATTTGAAAGGTTACCCACATTGAGCTCATACC
AGTGTGAAACTTCCATGGCATTATCTTTTAAATCCCTAAGATTAAAACCCCACACAAATGCACTCAAAGCAACCCAATATCAGTATCCTG
CAGTTTCTATGGGCCCTTTCTGCAGCCTTTACTCATGGAAGACAAGGGATCTGGGTTTGTTTAGGAAACATTTTGTGAGCATTGTCCAAG
CCCTAAGTATGGTTGGCCTAAGCTTTGCTGAAGCTAAGATCAGTCTGTTTATGTTTGCTTAAAATAGGAACTTAAAGGACTAAAATGTCA
TCATTATTTATCCTGATTATAGCCTAATGGTATTTTATTTTCTCTACAGCAATATGACTGCTAAAAGAACCAACCCAGGACAGAGCCACA
ATCTTCCTCTATTTCATTGTAATTTATATATTTCACTTGTATTCATTTGTAAAACTTTGTATTAGTGTAACATACTCCCCACAGTCTACT
TTTACAAACGCCTGTAAAGACTGGCATCTTCACAGGATGTCAGTGTTTAAATTTAGTAAACTTCTTTTTTGTTTGTTTATTTGTTTTTGT
TTTTTTTTAAGGAATGAGGAAACAAACCACCCTCTGGGGGTAATTTACAGACTGAGTGACAGTACTCAGTATATCTGAGATAAACTCTAT
AATGTTTTGGATAAAAATAACATTCCAATCACTATTGTATATATGTGCATGTATTTTTTAAATTAAAGATGTCTAGTTGCTTTTTATAAG
ACCAAGAAGGAGAAAATCCGACAACCTGGAAAGATTTTTGTTTTCACTGCTTGTATGATGTTTCCCATTCATACACCTATAAATCTCTAA
CAAGAGGCCCTTTGAACTGCCTTGTGTTCTGTGAGAAACAAATATTTACTTAGAGTGGAAGGACTGATTGAGAATGTTCCAATCCAAATG
AATGCATCACAACTTACAATGCTGCTCATTGTTGTGAGTACTATGAGATTCAAATTTTTCTAACATATGGAAAGCCTTTTGTCCTCCAAA
GATGAGTACTAGGGATCATGTGTTTAAAAAAAGAAAGGCTACGATGACTGGGCAAGAAGAAAGATGGGAAACTGAATAAAGCAGTTGATC
AGCATCATTGGAACATGGGGACGAGTGACGGCAGGAGGACCACGAGGAAATACCCTCAAAACTAACTTGTTTACAACAAAATAAAGTATT

>85693_85693_1_SPECC1L-TM4SF1_SPECC1L_chr22_24765288_ENST00000314328_TM4SF1_chr3_149089654_ENST00000472441_length(amino acids)=1041AA_BP=
MKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPA
MTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAA
LEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDR
LNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD
DALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLC
QQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKER
SHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDL
AHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKK
LQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNY
MNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTA
LSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTTSPQLSLSSSPTASVTPTT

--------------------------------------------------------------
>85693_85693_2_SPECC1L-TM4SF1_SPECC1L_chr22_24765288_ENST00000437398_TM4SF1_chr3_149089654_ENST00000472441_length(transcript)=6135nt_BP=3290nt
GGCCAAGGGCGGGGCCCGCGAGGGAGGCCGGGCGGCCCGGCAAGCGGCGCTGCGGGGTAGGCTGCTTTCCTGAGGCCGGACTCAACGGGT
CTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGCGGTGCAGCGCGATTTGCTTGTAAAT
GCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTGTCTGCAATAAGTAAAACGCAAACAG
CAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGAACAGCAGCATCATTGTCAAAGACCA
AGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGAAAGAAAAGCACCTGCCCATCTGCAG
CACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACAGCTTCTTCAACCAAGCGGAGCACTT
CTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAGAGCAAAAAACTACCTTCTGCAGGTC
AGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTTCGTATGAGCAAGTCTAAGTCAGACA
ATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACCAAAGACGTAGAAATTTTACATTTGA
GAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAAAAATCTGAGAAGGAAACTATTATGG
CTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGTGAAGAACTCAACCAGCTGAAAAATG
AAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAATTCTGAAAAACTGTTTGGCTATCAGT
CCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTGGAAGGCTCTGCCCCTGGCTCAGTGG
AGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAATTTAGACAGTGAGTGCAGTGAGGTCT
ACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATCCCCAGCATAGAGCGCTCCCGGAAGG
GGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAAGAGAACCAACACAGTACAAGTGAGG
AACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAAAACGAAAGGCTTGGAGAAGAGAAGG
TTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAATACTTCCGCTCTCTTCTAGATGAGC
ATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGTTACATGGACCTCGCTGAGAATGCCC
GTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAACAAGACAATAAGGAAGCTCAAGAAA
TGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGAAAAGCAGCCTTGGCAGCCACGTTAG
AGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAGAATGAAAAGCAGAAAGTGGCAGAGC
TGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTGGACAAAGAAAAAGCAGAGACTTTGG
CTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATTGCTAAGGTAGAGGATGAATACCGAG
CCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCAGACCTGGATGAAAAAGAAACAGAAA
GGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAACTTCATGACAACCTCATTATTTCTG
ATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACACTCCACAGAAGACTTCGGGAAGAAT
CTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAATCTGAAGCCCAAGAGGAGATTGGTG
ATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAAATAAAGTCACGCAAGCAAGAGGAGG
AGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGAATGGGACTGAGTAGAAGGTCCTCGA
CTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTACCAAACCCTGCTGCAGCTGCAATTC
CTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAGAGACATTCCATAAGTGGACCAATCT
CAACATCCAAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAAGAGCATCTGTTAAGAACATCTTCAG
CCAGCCGGCCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCTCGACGAAGTAGTGAAGAAGTGAAAC
GGGACATTTCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCACAGCTTTCCCTGTCCTCTTCTCCAA
CGGCATCTGTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCATTGGCCAGAGAATATGGAGGATCAA
AGAGGAACGCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGGTACCTTCTGGATACCTCCACATGGTCCGAGTGCACTGAA
CCCAAGCACATTGTGGAATGGAATGTATCTCTGTTTTCTATCCTCTTGGCTCTTGGTGGAATTGAATTCATCTTGTGTCTTATTCAAGTA
ATAAATGGAGTGCTTGGAGGCATATGTGGCTTTTGCTGCTCTCACCAACAGGTAAGAACCTGCATGAAAATGTCGTAGTCTGGCCCTGGT
GTTAATATACCATTGTTTTCATCATAAAGAAAAAGGCAAAACCAAACATGCTCGACCTACCAGCATTTATTCTGATATCATCTTTGTAGC
AACACAATTATAGCATTCACTTTAGCTGTCAGTAACAAGCTTCCTCGAGTCTCACAGTCACAGGATTGTCTTAGTTCTTTGCAGTTGGCT
CTATGTACACAAGAACATGCTGCCCATAGACACAGCGCTCCCTTCAGGATCTAATTCACTGCCTCTGCTCTCGCTGCAGAGACAGAAAAA
AAAGTGATGTCTGCTCTTTGTTTGCTGTTATATTCCCAACTAGTATACATAAGTAATAGCCAACCATTCAATGCATCAGGCACTATGCTA
AACCCATATGACTCAAATATTAAGCAATAGGCTTAAGATCACCTACTCAGGAAATAACAGGCTTCAAACCTTGAGTCGCTCTGTGCAAAA
GCTCCTACTTTTAACCTGTATTCCACACTTGCTGTTTGGTTGGATTTTCTGCAATTCCTTCCTAATAAGGAGTCATAAAAATGCCTAAGC
AGTAAGTATGGAGAATCACTAGCAATCTTTGAACAGCAGCTCATGAAAAGCCTTTCGTTGTGAAAGAAAACCAGGAAGCACTTGTTTCCT
GGGGATATGATTTAGGAGAAAAAAATGCATTTGTTTGTAGCAGTGAAAGTTCTTGTTTCTATATCCTCCTAAAATATATATATTATTGAA
TTAATGAAAGTCCAGCTTTGATCCTATCTTTGAGAGGGTTATTTTATGTCTTATATTTTTCAAACCATTTACTCCTCTGGTGCCAGATCT
GTTAACTTTCTTTTAAAAATAAGACAAAAACCTAATGAAAACTGAAAGCCCATTGCTACCATGAAAAACTTTGCTGAAAATAAAAGGAAA
CTTTCTGTAATTTTGGGGGAAGGTTAAAATGAAAATCTAGTTTTCCTTATCAGGCAAGTATAGCAAGATTAATAATTTCTTTGGCAAATT
TCCAAGAAAATAAGGGAATGGGAAACCTTCAATATGGAGCTTCTTTCAAGCAGTACGGTTGGGGAAGGGCAGAGAAGTATCCTCTAGGGA
TTGCTGTCATGCAGCTTACCTTTAGCCTTGAATTTCATACAAGGCAGAGTTCAAAGTAAGTGATTACTTGTACTAAATGTACTCACTTAG
TACGTTTTGGGGACAGGCATAAAGAGCCAATGACCAAAATGGCTGAAGTGATTTGGCAGGGAATGATACTCTCCTCTGATTTGGGGTAGT
AAATACACCAGGTTTCCCAGCTGAGTCACTGTAGGGATGGCTTCTTCCCAGATACTACAGGGAAGATCTGTTACCTTTGTTTATAAGACA
AAAGACACTTTCAAAGGGCAGGTCTTTTCATGTAGAAGAGTCAGGTCCATAACTCGGTAGCATTTAATTTGAAAGGTTACCCACATTGAG
CTCATACCAGTGTGAAACTTCCATGGCATTATCTTTTAAATCCCTAAGATTAAAACCCCACACAAATGCACTCAAAGCAACCCAATATCA
GTATCCTGCAGTTTCTATGGGCCCTTTCTGCAGCCTTTACTCATGGAAGACAAGGGATCTGGGTTTGTTTAGGAAACATTTTGTGAGCAT
TGTCCAAGCCCTAAGTATGGTTGGCCTAAGCTTTGCTGAAGCTAAGATCAGTCTGTTTATGTTTGCTTAAAATAGGAACTTAAAGGACTA
AAATGTCATCATTATTTATCCTGATTATAGCCTAATGGTATTTTATTTTCTCTACAGCAATATGACTGCTAAAAGAACCAACCCAGGACA
GAGCCACAATCTTCCTCTATTTCATTGTAATTTATATATTTCACTTGTATTCATTTGTAAAACTTTGTATTAGTGTAACATACTCCCCAC
AGTCTACTTTTACAAACGCCTGTAAAGACTGGCATCTTCACAGGATGTCAGTGTTTAAATTTAGTAAACTTCTTTTTTGTTTGTTTATTT
GTTTTTGTTTTTTTTTAAGGAATGAGGAAACAAACCACCCTCTGGGGGTAATTTACAGACTGAGTGACAGTACTCAGTATATCTGAGATA
AACTCTATAATGTTTTGGATAAAAATAACATTCCAATCACTATTGTATATATGTGCATGTATTTTTTAAATTAAAGATGTCTAGTTGCTT
TTTATAAGACCAAGAAGGAGAAAATCCGACAACCTGGAAAGATTTTTGTTTTCACTGCTTGTATGATGTTTCCCATTCATACACCTATAA
ATCTCTAACAAGAGGCCCTTTGAACTGCCTTGTGTTCTGTGAGAAACAAATATTTACTTAGAGTGGAAGGACTGATTGAGAATGTTCCAA
TCCAAATGAATGCATCACAACTTACAATGCTGCTCATTGTTGTGAGTACTATGAGATTCAAATTTTTCTAACATATGGAAAGCCTTTTGT
CCTCCAAAGATGAGTACTAGGGATCATGTGTTTAAAAAAAGAAAGGCTACGATGACTGGGCAAGAAGAAAGATGGGAAACTGAATAAAGC
AGTTGATCAGCATCATTGGAACATGGGGACGAGTGACGGCAGGAGGACCACGAGGAAATACCCTCAAAACTAACTTGTTTACAACAAAAT

>85693_85693_2_SPECC1L-TM4SF1_SPECC1L_chr22_24765288_ENST00000437398_TM4SF1_chr3_149089654_ENST00000472441_length(amino acids)=1077AA_BP=
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRD

--------------------------------------------------------------
>85693_85693_3_SPECC1L-TM4SF1_SPECC1L_chr22_24765288_ENST00000541492_TM4SF1_chr3_149089654_ENST00000472441_length(transcript)=6070nt_BP=3225nt
TTTCCTGAGGCCGGACTCAACGGGTCTCGGCTGAGCCACCGGGTGAGCTCACCGCCCAGCCCAAACCAGGAGATTGCGAGGGAGCGATGC
GGTGCAGCGCGATTTGCTTGTAAATGCATCACGAAGAGGCAGCCCAGAATGAAGAAAGCAAGCAGGAGTGTTGGCTCAGTGCCTAAAGTG
TCTGCAATAAGTAAAACGCAAACAGCAGAAAAAATTAAACCTGAAAACAGCTCTTCAGCATCTACGGGAGGCAAACTTGTAAAACCTGGA
ACAGCAGCATCATTGTCAAAGACCAAGAGCAGTGATGACCTTTTAGCTGGAATGGCCGGAGGGGTAACGGTGACTAATGGTGTTAAAGGA
AAGAAAAGCACCTGCCCATCTGCAGCACCTTCAGCATCTGCCCCTGCCATGACCACCGTGGAGAACAAATCCAAGATTAGCACAGGCACA
GCTTCTTCAACCAAGCGGAGCACTTCTACAGGTAATAAAGAATCCAGTTCTACTAGAGAAAGATTACGTGAACGTACCCGATTAAACCAG
AGCAAAAAACTACCTTCTGCAGGTCAGGGAGCTAATGACATGGCATTGGCCAAACGTTCCCGCAGTCGAACTGCTACAGAATGTGACGTT
CGTATGAGCAAGTCTAAGTCAGACAATCAGATCAGTGACAGAGCTGCTTTGGAGGCCAAAGTGAAGGATCTTCTCACGCTGGCAAAAACC
AAAGACGTAGAAATTTTACATTTGAGAAATGAACTGCGAGACATGCGTGCCCAGCTGGGCATTAATGAGGATCATTCTGAGGGTGATGAA
AAATCTGAGAAGGAAACTATTATGGCTCACCAGCCGACTGATGTGGAGTCCACTTTATTGCAGTTGCAGGAACAGAATACTGCCATCCGT
GAAGAACTCAACCAGCTGAAAAATGAAAACAGAATGTTAAAGGACAGGTTGAATGCATTGGGCTTTTCCCTAGAGCAGAGGTTAGACAAT
TCTGAAAAACTGTTTGGCTATCAGTCCCTGAGCCCAGAAATCACCCCTGATAACCAGAGCGATGGAGGAGGAACTCTGACTTCTTCAGTG
GAAGGCTCTGCCCCTGGCTCAGTGGAGGATCTCTTGAGTCAGGATGAAAATACACTAATGGACCATCAGCACAGTAACTCCATGGACAAT
TTAGACAGTGAGTGCAGTGAGGTCTACCAGCCCCTCACATCGAGCGATGATGCGCTGGATGCACCATCCTCCTCAGAGTCGGAAGGCATC
CCCAGCATAGAGCGCTCCCGGAAGGGGAGCAGCGGGAATGCCAGTGAAGTGTCCGTGGCTTGCCTGACTGAACGGATACACCAGATGGAA
GAGAACCAACACAGTACAAGTGAGGAACTCCAGGCAACCCTGCAAGAGCTAGCTGATTTACAGCAGATTACCCAGGAACTGAATAGTGAA
AACGAAAGGCTTGGAGAAGAGAAGGTTATTCTGATGGAGTCTTTATGTCAGCAGAGCGATAAGTTGGAACACTTTAGTCGACAGATTGAA
TACTTCCGCTCTCTTCTAGATGAGCATCACATTTCTTATGTCATAGATGAAGATGTAAAAAGTGGGCGCTATATGGAATTAGAGCAACGT
TACATGGACCTCGCTGAGAATGCCCGTTTTGAACGGGAGCAGCTTCTTGGTGTCCAGCAGCATTTAAGCAATACTTTGAAAATGGCAGAA
CAAGACAATAAGGAAGCTCAAGAAATGATAGGGGCACTCAAAGAACGCAGTCACCATATGGAGCGAATTATTGAGTCTGAGCAGAAAGGA
AAAGCAGCCTTGGCAGCCACGTTAGAGGAATACAAAGCCACAGTGGCCAGTGACCAGATAGAGATGAATCGCCTGAAGGCTCAGCTGGAG
AATGAAAAGCAGAAAGTGGCAGAGCTGTATTCTATCCATAACTCTGGAGACAAATCTGATATTCAGGACCTCCTGGAGAGTGTCAGGCTG
GACAAAGAAAAAGCAGAGACTTTGGCTAGTAGCTTGCAGGAAGATCTGGCTCATACCCGAAATGATGCCAATCGATTACAGGATGCCATT
GCTAAGGTAGAGGATGAATACCGAGCCTTCCAAGAAGAAGCTAAGAAACAAATTGAAGATTTGAATATGACGTTAGAAAAATTAAGATCA
GACCTGGATGAAAAAGAAACAGAAAGGAGTGACATGAAAGAAACCATCTTTGAACTTGAAGATGAAGTAGAACAACATCGTGCTGTGAAA
CTTCATGACAACCTCATTATTTCTGATCTAGAGAATACAGTTAAAAAACTCCAGGACCAAAAGCACGACATGGAAAGAGAAATAAAGACA
CTCCACAGAAGACTTCGGGAAGAATCTGCGGAATGGCGGCAGTTTCAGGCTGATCTCCAGACTGCAGTAGTCATTGCAAATGACATTAAA
TCTGAAGCCCAAGAGGAGATTGGTGATCTAAAGCGCCGGTTACATGAGGCTCAAGAAAAAAATGAGAAACTCACAAAAGAATTGGAGGAA
ATAAAGTCACGCAAGCAAGAGGAGGAGCGAGGCCGGGTATACAATTACATGAATGCCGTTGAGAGAGATTTGGCAGCCTTAAGGCAGGGA
ATGGGACTGAGTAGAAGGTCCTCGACTTCCTCAGAGCCAACTCCTACAGTAAAAACCCTCATCAAGTCCTTTGACAGTGCATCTCAAGTA
CCAAACCCTGCTGCAGCTGCAATTCCTCGAACGCCCCTGAGCCCAAGTCCTATGAAAACCCCTCCTGCAGCAGCTGTGTCCCCTATGCAG
AGACATTCCATAAGTGGACCAATCTCAACATCCAAACCCCTGACAGCCCTGTCAGATAAGAGACCAAACTATGGGGAAATCCCTGTTCAA
GAGCATCTGTTAAGAACATCTTCAGCCAGCCGGCCTGCTTCCCTGCCAAGAGTGCCTGCGATGGAAAGTGCCAAGACCCTCTCAGTGTCT
CGACGAAGTAGTGAAGAAGTGAAACGGGACATTTCTGCACAGGAGGGAGCGTCGCCAGCCTCTCTGATGGCTATGGGAACCACGTCTCCA
CAGCTTTCCCTGTCCTCTTCTCCAACGGCATCTGTGACTCCCACCACCCGAAGCCGAATAAGAGAAGAAAGGAAAGACCCTCTCTCAGCA
TTGGCCAGAGAATATGGAGGATCAAAGAGGAACGCCTTGCTGAAGTGGTGTCAGAAGAAAACAGAAGGCTATCAGGTACCTTCTGGATAC
CTCCACATGGTCCGAGTGCACTGAACCCAAGCACATTGTGGAATGGAATGTATCTCTGTTTTCTATCCTCTTGGCTCTTGGTGGAATTGA
ATTCATCTTGTGTCTTATTCAAGTAATAAATGGAGTGCTTGGAGGCATATGTGGCTTTTGCTGCTCTCACCAACAGGTAAGAACCTGCAT
GAAAATGTCGTAGTCTGGCCCTGGTGTTAATATACCATTGTTTTCATCATAAAGAAAAAGGCAAAACCAAACATGCTCGACCTACCAGCA
TTTATTCTGATATCATCTTTGTAGCAACACAATTATAGCATTCACTTTAGCTGTCAGTAACAAGCTTCCTCGAGTCTCACAGTCACAGGA
TTGTCTTAGTTCTTTGCAGTTGGCTCTATGTACACAAGAACATGCTGCCCATAGACACAGCGCTCCCTTCAGGATCTAATTCACTGCCTC
TGCTCTCGCTGCAGAGACAGAAAAAAAAGTGATGTCTGCTCTTTGTTTGCTGTTATATTCCCAACTAGTATACATAAGTAATAGCCAACC
ATTCAATGCATCAGGCACTATGCTAAACCCATATGACTCAAATATTAAGCAATAGGCTTAAGATCACCTACTCAGGAAATAACAGGCTTC
AAACCTTGAGTCGCTCTGTGCAAAAGCTCCTACTTTTAACCTGTATTCCACACTTGCTGTTTGGTTGGATTTTCTGCAATTCCTTCCTAA
TAAGGAGTCATAAAAATGCCTAAGCAGTAAGTATGGAGAATCACTAGCAATCTTTGAACAGCAGCTCATGAAAAGCCTTTCGTTGTGAAA
GAAAACCAGGAAGCACTTGTTTCCTGGGGATATGATTTAGGAGAAAAAAATGCATTTGTTTGTAGCAGTGAAAGTTCTTGTTTCTATATC
CTCCTAAAATATATATATTATTGAATTAATGAAAGTCCAGCTTTGATCCTATCTTTGAGAGGGTTATTTTATGTCTTATATTTTTCAAAC
CATTTACTCCTCTGGTGCCAGATCTGTTAACTTTCTTTTAAAAATAAGACAAAAACCTAATGAAAACTGAAAGCCCATTGCTACCATGAA
AAACTTTGCTGAAAATAAAAGGAAACTTTCTGTAATTTTGGGGGAAGGTTAAAATGAAAATCTAGTTTTCCTTATCAGGCAAGTATAGCA
AGATTAATAATTTCTTTGGCAAATTTCCAAGAAAATAAGGGAATGGGAAACCTTCAATATGGAGCTTCTTTCAAGCAGTACGGTTGGGGA
AGGGCAGAGAAGTATCCTCTAGGGATTGCTGTCATGCAGCTTACCTTTAGCCTTGAATTTCATACAAGGCAGAGTTCAAAGTAAGTGATT
ACTTGTACTAAATGTACTCACTTAGTACGTTTTGGGGACAGGCATAAAGAGCCAATGACCAAAATGGCTGAAGTGATTTGGCAGGGAATG
ATACTCTCCTCTGATTTGGGGTAGTAAATACACCAGGTTTCCCAGCTGAGTCACTGTAGGGATGGCTTCTTCCCAGATACTACAGGGAAG
ATCTGTTACCTTTGTTTATAAGACAAAAGACACTTTCAAAGGGCAGGTCTTTTCATGTAGAAGAGTCAGGTCCATAACTCGGTAGCATTT
AATTTGAAAGGTTACCCACATTGAGCTCATACCAGTGTGAAACTTCCATGGCATTATCTTTTAAATCCCTAAGATTAAAACCCCACACAA
ATGCACTCAAAGCAACCCAATATCAGTATCCTGCAGTTTCTATGGGCCCTTTCTGCAGCCTTTACTCATGGAAGACAAGGGATCTGGGTT
TGTTTAGGAAACATTTTGTGAGCATTGTCCAAGCCCTAAGTATGGTTGGCCTAAGCTTTGCTGAAGCTAAGATCAGTCTGTTTATGTTTG
CTTAAAATAGGAACTTAAAGGACTAAAATGTCATCATTATTTATCCTGATTATAGCCTAATGGTATTTTATTTTCTCTACAGCAATATGA
CTGCTAAAAGAACCAACCCAGGACAGAGCCACAATCTTCCTCTATTTCATTGTAATTTATATATTTCACTTGTATTCATTTGTAAAACTT
TGTATTAGTGTAACATACTCCCCACAGTCTACTTTTACAAACGCCTGTAAAGACTGGCATCTTCACAGGATGTCAGTGTTTAAATTTAGT
AAACTTCTTTTTTGTTTGTTTATTTGTTTTTGTTTTTTTTTAAGGAATGAGGAAACAAACCACCCTCTGGGGGTAATTTACAGACTGAGT
GACAGTACTCAGTATATCTGAGATAAACTCTATAATGTTTTGGATAAAAATAACATTCCAATCACTATTGTATATATGTGCATGTATTTT
TTAAATTAAAGATGTCTAGTTGCTTTTTATAAGACCAAGAAGGAGAAAATCCGACAACCTGGAAAGATTTTTGTTTTCACTGCTTGTATG
ATGTTTCCCATTCATACACCTATAAATCTCTAACAAGAGGCCCTTTGAACTGCCTTGTGTTCTGTGAGAAACAAATATTTACTTAGAGTG
GAAGGACTGATTGAGAATGTTCCAATCCAAATGAATGCATCACAACTTACAATGCTGCTCATTGTTGTGAGTACTATGAGATTCAAATTT
TTCTAACATATGGAAAGCCTTTTGTCCTCCAAAGATGAGTACTAGGGATCATGTGTTTAAAAAAAGAAAGGCTACGATGACTGGGCAAGA
AGAAAGATGGGAAACTGAATAAAGCAGTTGATCAGCATCATTGGAACATGGGGACGAGTGACGGCAGGAGGACCACGAGGAAATACCCTC

>85693_85693_3_SPECC1L-TM4SF1_SPECC1L_chr22_24765288_ENST00000541492_TM4SF1_chr3_149089654_ENST00000472441_length(amino acids)=1077AA_BP=
MSHRVSSPPSPNQEIARERCGAARFACKCITKRQPRMKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKS
SDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQG
ANDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSEGDEKSEKETIMAH
QPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVED
LLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEEL
QATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARF
EREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELY
SIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERS
DMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDL
KRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPR
TPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPECC1L-TM4SF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPECC1L-TM4SF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPECC1L-TM4SF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource