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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPG11-JMJD7 (FusionGDB2 ID:85740)

Fusion Gene Summary for SPG11-JMJD7

check button Fusion gene summary
Fusion gene informationFusion gene name: SPG11-JMJD7
Fusion gene ID: 85740
HgeneTgene
Gene symbol

SPG11

JMJD7

Gene ID

80208

100137047

Gene nameSPG11 vesicle trafficking associated, spatacsinjumonji domain containing 7
SynonymsALS5|CMT2X|KIAA1840-
Cytomap

15q21.1

15q15.1

Type of geneprotein-codingprotein-coding
DescriptionspatacsinSPG11, spatacsin vesicle trafficking associatedamyotrophic lateral sclerosis 5colorectal carcinoma-associated proteinspastic paraplegia 11 (autosomal recessive)spastic paraplegia 11 proteinbifunctional peptidase and (3S)-lysyl hydroxylase JMJD7L-lysine (3S)-hydroxylase JMJD7jmjC domain-containing protein 7jumonji domain-containing protein 7
Modification date2020032920200313
UniProtAcc.

P0C870

Ensembl transtripts involved in fusion geneENST00000261866, ENST00000427534, 
ENST00000535302, ENST00000558319, 
ENST00000558253, ENST00000559193, 
ENST00000405106, ENST00000408047, 
ENST00000397299, 
Fusion gene scores* DoF score11 X 11 X 7=8472 X 1 X 2=4
# samples 123
** MAII scorelog2(12/847*10)=-2.81932756372368
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/4*10)=2.90689059560852
Context

PubMed: SPG11 [Title/Abstract] AND JMJD7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPG11(44880765)-JMJD7(42126938), # samples:1
SPG11(44881450)-JMJD7(42126938), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneJMJD7

GO:0018126

protein hydroxylation

29915238


check buttonFusion gene breakpoints across SPG11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across JMJD7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-4223-01ASPG11chr15

44881450

-JMJD7chr15

42126938

+
ChimerDB4HNSCTCGA-BB-4223SPG11chr15

44880765

-JMJD7chr15

42126938

+


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Fusion Gene ORF analysis for SPG11-JMJD7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261866ENST00000405106SPG11chr15

44881450

-JMJD7chr15

42126938

+
5CDS-3UTRENST00000427534ENST00000405106SPG11chr15

44881450

-JMJD7chr15

42126938

+
5CDS-3UTRENST00000535302ENST00000405106SPG11chr15

44881450

-JMJD7chr15

42126938

+
5CDS-3UTRENST00000558319ENST00000405106SPG11chr15

44881450

-JMJD7chr15

42126938

+
5CDS-intronENST00000261866ENST00000408047SPG11chr15

44881450

-JMJD7chr15

42126938

+
5CDS-intronENST00000427534ENST00000408047SPG11chr15

44881450

-JMJD7chr15

42126938

+
5CDS-intronENST00000535302ENST00000408047SPG11chr15

44881450

-JMJD7chr15

42126938

+
5CDS-intronENST00000558319ENST00000408047SPG11chr15

44881450

-JMJD7chr15

42126938

+
5UTR-3CDSENST00000558253ENST00000397299SPG11chr15

44881450

-JMJD7chr15

42126938

+
5UTR-3UTRENST00000558253ENST00000405106SPG11chr15

44881450

-JMJD7chr15

42126938

+
5UTR-intronENST00000558253ENST00000408047SPG11chr15

44881450

-JMJD7chr15

42126938

+
In-frameENST00000261866ENST00000397299SPG11chr15

44881450

-JMJD7chr15

42126938

+
In-frameENST00000427534ENST00000397299SPG11chr15

44881450

-JMJD7chr15

42126938

+
In-frameENST00000535302ENST00000397299SPG11chr15

44881450

-JMJD7chr15

42126938

+
In-frameENST00000558319ENST00000397299SPG11chr15

44881450

-JMJD7chr15

42126938

+
intron-3CDSENST00000261866ENST00000397299SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3CDSENST00000427534ENST00000397299SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3CDSENST00000535302ENST00000397299SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3CDSENST00000558253ENST00000397299SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3CDSENST00000558319ENST00000397299SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3CDSENST00000559193ENST00000397299SPG11chr15

44881450

-JMJD7chr15

42126938

+
intron-3CDSENST00000559193ENST00000397299SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3UTRENST00000261866ENST00000405106SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3UTRENST00000427534ENST00000405106SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3UTRENST00000535302ENST00000405106SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3UTRENST00000558253ENST00000405106SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3UTRENST00000558319ENST00000405106SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-3UTRENST00000559193ENST00000405106SPG11chr15

44881450

-JMJD7chr15

42126938

+
intron-3UTRENST00000559193ENST00000405106SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-intronENST00000261866ENST00000408047SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-intronENST00000427534ENST00000408047SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-intronENST00000535302ENST00000408047SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-intronENST00000558253ENST00000408047SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-intronENST00000558319ENST00000408047SPG11chr15

44880765

-JMJD7chr15

42126938

+
intron-intronENST00000559193ENST00000408047SPG11chr15

44881450

-JMJD7chr15

42126938

+
intron-intronENST00000559193ENST00000408047SPG11chr15

44880765

-JMJD7chr15

42126938

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261866SPG11chr1544881450-ENST00000397299JMJD7chr1542126938+623549231758091930
ENST00000535302SPG11chr1544881450-ENST00000397299JMJD7chr1542126938+624649342858201930
ENST00000427534SPG11chr1544881450-ENST00000397299JMJD7chr1542126938+62184906057921930
ENST00000558319SPG11chr1544881450-ENST00000397299JMJD7chr1542126938+624949373158231930

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261866ENST00000397299SPG11chr1544881450-JMJD7chr1542126938+0.0008806980.99911934
ENST00000535302ENST00000397299SPG11chr1544881450-JMJD7chr1542126938+0.0008913310.9991086
ENST00000427534ENST00000397299SPG11chr1544881450-JMJD7chr1542126938+0.0008700640.99912995
ENST00000558319ENST00000397299SPG11chr1544881450-JMJD7chr1542126938+0.0008892490.99911076

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Fusion Genomic Features for SPG11-JMJD7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPG11chr1544881449-JMJD7chr1542126937+4.47E-081
SPG11chr1544881449-JMJD7chr1542126937+4.47E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPG11-JMJD7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:44880765/chr15:42126938)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.JMJD7

P0C870

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238). {ECO:0000269|PubMed:28847961, ECO:0000269|PubMed:29915238}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneJMJD7chr15:44881450chr15:42126938ENST0000039729908128_30721317.0DomainJmjC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SPG11-JMJD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85740_85740_1_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000261866_JMJD7_chr15_42126938_ENST00000397299_length(transcript)=6235nt_BP=4923nt
GTAACCGCCGGGCCAAGATGGCTGCAGAGGAAGGGGTCGCGAGTGCTGCTTCCGCCGGCGGTAGCTGGGGCACCGCGGCCATGGGGCGGG
TTCTACCGATGCTGTTGGTGCCAGTCCCCGCCGAGGCGATGGGGCAGCTCGGCTCCCGGGCGCAGCTGCGCACACAGCCGGAGGCTCTGG
GGAGCCTGACGGCTGCGGGCAGCCTCCAAGTGCTTTCTTTGACGCCTGGCAGCCGGGGCGGGGGTCGCTGCTGCCTGGAGGGCCCCTTCT
GGCACTTTCTATGGGAGGATTCTCGTAACAGCAGCACACCAACTGAAAAGCCCAAACTGCTCGCTCTTGGTGAAAATTATGAACTGCTTA
TCTATGAATTTAATTTGAAAGATGGAAGATGTGATGCAACCATTTTGTATAGCTGTAGTAGGGAGGCATTGCAAAAGCTCATTGACGATC
AAGATATCAGTATTTCCTTATTGTCTTTGAGAATCCTGTCATTTCACAATAACACATCATTACTGTTCATCAACAAATGTGTCATCCTAC
ATATTATATTTCCTGAAAGAGATGCTGCAATTAGAGTACTCAACTGTTTCACACTTCCCTTGCCTGCACAGGCAGTGGACATGATTATTG
ACACGCAGCTCTGCAGAGGAATTCTTTTTGTTTTGAGTAGTTTAGGCTGGATCTACATTTTTGATGTTGTGGATGGTACATATGTAGCTC
ATGTGGATTTAGCACTTCACAAAGAAGACATGTGTAATGAGCAGCAACAGGAGCCAGCCAAGATTTCTTCATTTACTTCACTGAAAGTTT
CTCAAGACCTCGATGTTGCAGTGATTGTCAGCTCCTCCAACTCCGCAGTTGCTCTTAACTTAAATTTGTATTTCAGGCAACACCCAGGAC
ACCTACTGTGTGAAAGAATACTAGAAGATCTTCCTATTCAAGGACCTAAGGGCGTAGATGAAGATGATCCTGTTAACTCTGCCTACAACA
TGAAACTGGCCAAGTTTTCCTTCCAAATTGATAGGTCTTGGAAAGCCCAGCTATCATCATTGAATGAAACAATAAAGAACTCCAAACTGG
AGGTTTCCTGTTGTGCTCCATGGTTCCAGGATATTTTGCATTTGGAGTCACCTGAATCTGGTAACCACAGTACAAGTGTGCAGAGCTGGG
CCTTCATTCCACAGGACATAATGCATGGGCAATATAATGTTCTACAGAAAGATCATGCCAAGACCAGTGATCCAGGAAGATCATGGAAAA
TAATGCACATCAGTGAACAAGAGGAACCCATAGAGCTTAAATGTGTGTCTGTGACAGGATTCACTGCACTGTTTACTTGGGAAGTGGAAA
GGATGGGCTATACCATTACCCTCTGGGATTTGGAGACCCAGGGCATGCAGTGTTTTTCCCTTGGCACAAAGTGTATTCCTGTAGACAGTA
GTGGAGACCAGCAGCTGTGCTTTGTTTTGACAGAGAATGGACTCTCTCTGATTTTGTTTGGTTTGACTCAAGAAGAGTTTTTAAACAGAC
TCATGATCCATGGAAGTGCCAGCACTGTGGACACTCTTTGTCATCTCAATGGCTGGGGAAGGTGCTCAATTCCCATACATGCACTAGAGG
CCGGGATAGAAAATCGTCAGCTGGACACAGTAAATTTCTTTTTGAAGAGCAAGGAAAATCTTTTTAATCCATCCTCAAAATCTTCTGTAT
CTGATCAGTTTGATCACTTGTCATCCCATTTATATTTAAGAAATGTGGAAGAGCTGATACCAGCATTGGATTTACTTTGCTCGGCAATTA
GAGAAAGTTATTCTGAACCCCAAAGCAAACACTTTTCAGAACAATTGCTTAATCTTACACTGTCTTTCCTTAACAACCAAATAAAGGAGC
TTTTCATTCACACTGAAGAACTAGATGAACATCTGCAAAAAGGAGTGAACATTTTGACTAGCTACATTAATGAACTTCGAACCTTCATGA
TAAAGTTTCCTTGGAAGCTAACAGATGCTATAGATGAATATGATGTACATGAAAATGTCCCCAAAGTAAAGGAGAGCAATATATGGAAGA
AACTCAGCTTTGAGGAAGTTATTGCCAGCGCCATTTTAAACAACAAAATACCAGAGGCACAGACTTTCTTCAGGATTGATAGTCATTCTG
CTCAAAAACTTGAGGAGCTTATTGGCATAGGCCTAAATTTGGTCTTTGACAATTTAAAAAAGAACAATATAAAGGAAGCCTCTGAACTTT
TGAAGAATATGGGGTTTGATGTAAAAGGCCAATTGCTCAAGATCTGCTTCTATACAACTAATAAAAATATACGTGACTTTTTGGTTGAAA
TTTTAAAAGAAAAAAATTATTTTTCTGAAAAAGAGAAAAGAACTATAGACTTCGTGCATCAAGTTGAGAAGCTTTATTTGGGACATTTCC
AAGAAAATATGCAAATCCAGTCATTTCCCAGGTACTGGATAAAGGAACAAGATTTTTTCAAGCACAAGTCTGTTTTGGACTCATTCCTGA
AATATGATTGTAAAGATGAATTTAACAAACAGGACCATAGAATTGTGTTAAATTGGGCTCTGTGGTGGGATCAACTAACACAAGAATCCA
TCCTTCTCCCCAGGATAAGTCCAGAAGAATACAAATCATATTCCCCTGAAGCCCTCTGGAGATACCTCACAGCTCGCCATGATTGGTTAA
ACATTATCTTATGGATTGGAGAATTTCAAACCCAGCATAGTTATGCTTCACTTCAGCAGAACAAATGGCCCCTTCTGACTGTTGATGTTA
TTAACCAGAATACTTCCTGTAACAACTACATGAGGAATGAAATTTTAGATAAGCTGGCCAGGAATGGGGTTTTTTTGGCATCTGAACTGG
AAGACTTTGAATGCTTCCTCCTAAGACTGAGCCGTATTGGAGGTGTAATACAGGATACCCTCCCTGTTCAAAACTACAAGACCAAAGAAG
GTTGGGATTTCCATTCTCAATTCATTCTCTATTGTTTGGAGCACAGTCTGCAGCATCTTCTTTATGTCTACCTTGACTGTTACAAACTTA
GTCCTGAAAATTGTCCCTTTTTGGAAAAAAAAGAGTTACATGAAGCACACCCTTGGTTTGAATTTTTAGTTCAGTGTCGACAAGTTGCCA
GTAACTTAACAGATCCCAAACTGATCTTCCAGGCTAGCCTTGCAAATGCTCAGATTTTGATTCCCACCAATCAGGCCAGTGTAAGCAGTA
TGCTATTGGAAGGACATACCCTCCTGGCCCTTGCTACTACAATGTATTCTCCTGGGGGTGTCAGTCAGGTTGTTCAGAATGAAGAAAATG
AAAACTGTTTGAAGAAAGTGGATCCCCAGCTATTGAAGATGGCATTAACTCCTTACCCCAAGCTAAAAACTGCTCTCTTCCCACAGTGCA
CTCCTCCTAGTGTCCTGCCATCTGATATTACAATCTACCACCTTATTCAGTCATTATCACCCTTTGATCCTAGCAGATTGTTTGGCTGGC
AGTCTGCTAACACACTAGCTATAGGAGATGCATGGAGTCATCTCCCACATTTCTCTAGCCCTGACCTGGTTAATAAATATGCTATAGTGG
AACGTCTGAATTTTGCTTATTATTTACATAATGGGCGGCCATCATTTGCATTTGGTACTTTTCTGGTCCAGGAATTAATCAAGAGCAAGA
CTCCCAAGCAGCTGATCCAGCAAGTAGGCAATGAAGCCTATGTTATAGGGCTCTCCTCCTTCCACATACCTTCAATAGGAGCTGCATGTG
TTTGTTTCTTAGAATTGCTTGGCCTTGACAGCCTCAAGCTCAGAGTTGATATGAAAGTGGCCAATATAATTTTGAGCTACAAGTGCAGAA
ATGAAGATGCTCAGTACAGCTTTATCAGAGAGTCTGTAGCCGAAAAACTATCTAAACTAGCTGATGGTGAAAAGACAACCACAGAAGAAT
TGCTTGTTCTCTTAGAAGAAGGTACATGGAACAGCATTCAGCAACAGGAAATAAAGAGGTTATCCAGTGAATCTAGCAGCCAATGGGCAT
TAGTGGTGCAGTTCTGCAGGCTACACAATATGAAACTAAGCATATCTTACCTTAGAGAATGTGCCAAAGCAAATGATTGGCTGCAGTTCA
TTATTCACAGCCAACTCCACAACTACCACCCAGCAGAGGTGAAATCCCTTATCCAGTACTTCAGCCCAGTCATTCAAGACCACTTAAGGC
TGGCTTTTGAGAACTTGCCCTCAGTGCCCACCTCCAAAATGGACAGCGATCAAGTCTGCAATAAGTGCCCCCAGGAACTTCAAGGAAGCA
AACAAGAGATGACCGATTTATTTGAAATTCTGCTCCAATGCTCAGAGGAGCCAGACTCCTGGCACTGGCTTCTGGTTGAAGCAGTGAAAC
AACAGGCCCCTATCCTCAGTGTTCTGGCCTCATGTCTCCAGGGTGCCAGTGCCATTTCTTGTCTCTGTGTTTGGATCATCACTTCTGTGG
AGGACAATGTTGCAACTGAAGCAATGGGACACATTCAGGACTCAACAGAGGACCATACCTGGAACCTTGAGGATCTTTCAGTCATCTGGA
GAACATTATTAACAAGACAAAAGAGCAAAACTCTCATCAGAGGTTTCCAGCTTTTCTTTAAGGATTCCCCGTTACTACTGGTGATGGAGA
TGTATGAACTGTGTATGTTCTTCAGGAATTATAAAGAAGCTGAAGCTAAACTTCTGGAGTTTCAGAAGAGCCTTGAAACGCTTAACACAG
CAGCCACAAAGGTCCACCCTGTCATCCCTGCCATGTGGCTGGAGGATCAGGTGTGTTTCCTTTTGAAGCTTATGCTACAGCAGTGTAAGA
CCCAGTATGAGCTGGGGAAGCTTTTACAGCTCTTTGTTGAAAGAGAGCATCTCTTCTCTGATGAGCTCTGCGTGCCTCTTGCTGTGCCCT
ACCTGGACAAACCCCCAACTCCGCTCCACTTCTACCGGGACTGGGTCTGCCCCAACAGGCCGTGCATTATCCGCAACGCTCTGCAGCACT
GGCCGGCCCTCCAGAAGTGGTCCCTCCCCTATTTCAGAGCCACAGTGGGCTCCACAGAGGTGAGTGTGGCCGTGACCCCAGATGGTTACG
CGGATGCCGTGAGAGGGGATCGCTTCATGATGCCAGCTGAGCGCCGCCTGCCCCTGAGCTTCGTGCTGGATGTGCTGGAGGGCCGGGCCC
AGCACCCTGGAGTCCTCTATGTGCAGAAGCAGTGCTCCAACCTGCCCAGCGAGCTGCCCCAGCTGCTGCCTGATCTGGAATCCCATGTGC
CCTGGGCCTCCGAAGCCCTGGGAAAGATGCCCGATGCTGTGAACTTCTGGCTGGGGGAGGCGGCTGCAGTGACTTCTTTGCACAAGGACC
ACTATGAGAACCTCTACTGCGTGGTCTCAGGAGAGAAGCATTTCCTGTTCCATCCGCCCAGCGACCGGCCCTTCATCCCCTATGAGCTGT
ACACGCCGGCAACCTACCAGCTAACTGAAGAGGGCACCTTTAAGGTGGTGGATGAAGAGGCCATGGAGAAGGTGCCCTGGATCCCACTGG
ACCCCTTGGCGCCAGACCTAGCACGGTACCCTAGTTACAGTCAGGCCCAGGCCCTTCGCTGCACGGTGCGGGCCGGTGAGATGCTCTATC
TGCCGGCTCTGTGGTTCCACCACGTCCAGCAGTCCCAGGGCTGCATCGCAGTGAATTTCTGGTATGACATGGAATACGACCTCAAGTATA
GTTACTTCCAGCTGCTCGACTCCCTCACCAAGGCTTCAGGCCTTGACTGATGGAGCACTGGTGAACACCACCAAGCACGCCTCGGGGGAC
GGAGCCAGCCCCTCCCTGGCCAGGTCAATTCTCGAGAGAGCCTGGAGTGTGCATGCTGGCTGCTGGCCCCGGGTCCAGCATGGCTTGAGA
TCAGCTTTGGAGGATCTTGGAATGTGGTCATAAGGACTCAAGGTGCCAGGCAGGTCTGGGTGAGGGTTCTCAGGAAGTTGCCACACAGGT
GAGCAGAGTGGGGATCAGGTGCAGCGGCACCTCTCCCCAGCGCTGTGATGTTGGGCGAGTCACTGCGTCTCGGGCATTGGTGTCCTGTCA
GTAAAGAGATAATAATGGCTGTACCTCGCGGGGCTGTTGTGGGCTTGGAGATGATGTCTATGAGGACCAGCATGGAGCTGGCACACAGGA

>85740_85740_1_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000261866_JMJD7_chr15_42126938_ENST00000397299_length(amino acids)=1930AA_BP=1635
MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSRAQLRTQPEALGSLTAAGSLQVLSLTPGSRGGGRCCLEGPFWHFLWE
DSRNSSTPTEKPKLLALGENYELLIYEFNLKDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFHNNTSLLFINKCVILHIIFPE
RDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSSLGWIYIFDVVDGTYVAHVDLALHKEDMCNEQQQEPAKISSFTSLKVSQDLDV
AVIVSSSNSAVALNLNLYFRQHPGHLLCERILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQIDRSWKAQLSSLNETIKNSKLEVSCCA
PWFQDILHLESPESGNHSTSVQSWAFIPQDIMHGQYNVLQKDHAKTSDPGRSWKIMHISEQEEPIELKCVSVTGFTALFTWEVERMGYTI
TLWDLETQGMQCFSLGTKCIPVDSSGDQQLCFVLTENGLSLILFGLTQEEFLNRLMIHGSASTVDTLCHLNGWGRCSIPIHALEAGIENR
QLDTVNFFLKSKENLFNPSSKSSVSDQFDHLSSHLYLRNVEELIPALDLLCSAIRESYSEPQSKHFSEQLLNLTLSFLNNQIKELFIHTE
ELDEHLQKGVNILTSYINELRTFMIKFPWKLTDAIDEYDVHENVPKVKESNIWKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEE
LIGIGLNLVFDNLKKNNIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKNYFSEKEKRTIDFVHQVEKLYLGHFQENMQI
QSFPRYWIKEQDFFKHKSVLDSFLKYDCKDEFNKQDHRIVLNWALWWDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWI
GEFQTQHSYASLQQNKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECFLLRLSRIGGVIQDTLPVQNYKTKEGWDFHS
QFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHEAHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGH
TLLALATTMYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITIYHLIQSLSPFDPSRLFGWQSANTL
AIGDAWSHLPHFSSPDLVNKYAIVERLNFAYYLHNGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLEL
LGLDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLEEGTWNSIQQQEIKRLSSESSSQWALVVQFC
RLHNMKLSISYLRECAKANDWLQFIIHSQLHNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQEMTD
LFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQGASAISCLCVWIITSVEDNVATEAMGHIQDSTEDHTWNLEDLSVIWRTLLTR
QKSKTLIRGFQLFFKDSPLLLVMEMYELCMFFRNYKEAEAKLLEFQKSLETLNTAATKVHPVIPAMWLEDQVCFLLKLMLQQCKTQYELG
KLLQLFVEREHLFSDELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRG
DRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLY
CVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWF

--------------------------------------------------------------
>85740_85740_2_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000427534_JMJD7_chr15_42126938_ENST00000397299_length(transcript)=6218nt_BP=4906nt
ATGGCTGCAGAGGAAGGGGTCGCGAGTGCTGCTTCCGCCGGCGGTAGCTGGGGCACCGCGGCCATGGGGCGGGTTCTACCGATGCTGTTG
GTGCCAGTCCCCGCCGAGGCGATGGGGCAGCTCGGCTCCCGGGCGCAGCTGCGCACACAGCCGGAGGCTCTGGGGAGCCTGACGGCTGCG
GGCAGCCTCCAAGTGCTTTCTTTGACGCCTGGCAGCCGGGGCGGGGGTCGCTGCTGCCTGGAGGGCCCCTTCTGGCACTTTCTATGGGAG
GATTCTCGTAACAGCAGCACACCAACTGAAAAGCCCAAACTGCTCGCTCTTGGTGAAAATTATGAACTGCTTATCTATGAATTTAATTTG
AAAGATGGAAGATGTGATGCAACCATTTTGTATAGCTGTAGTAGGGAGGCATTGCAAAAGCTCATTGACGATCAAGATATCAGTATTTCC
TTATTGTCTTTGAGAATCCTGTCATTTCACAATAACACATCATTACTGTTCATCAACAAATGTGTCATCCTACATATTATATTTCCTGAA
AGAGATGCTGCAATTAGAGTACTCAACTGTTTCACACTTCCCTTGCCTGCACAGGCAGTGGACATGATTATTGACACGCAGCTCTGCAGA
GGAATTCTTTTTGTTTTGAGTAGTTTAGGCTGGATCTACATTTTTGATGTTGTGGATGGTACATATGTAGCTCATGTGGATTTAGCACTT
CACAAAGAAGACATGTGTAATGAGCAGCAACAGGAGCCAGCCAAGATTTCTTCATTTACTTCACTGAAAGTTTCTCAAGACCTCGATGTT
GCAGTGATTGTCAGCTCCTCCAACTCCGCAGTTGCTCTTAACTTAAATTTGTATTTCAGGCAACACCCAGGACACCTACTGTGTGAAAGA
ATACTAGAAGATCTTCCTATTCAAGGACCTAAGGGCGTAGATGAAGATGATCCTGTTAACTCTGCCTACAACATGAAACTGGCCAAGTTT
TCCTTCCAAATTGATAGGTCTTGGAAAGCCCAGCTATCATCATTGAATGAAACAATAAAGAACTCCAAACTGGAGGTTTCCTGTTGTGCT
CCATGGTTCCAGGATATTTTGCATTTGGAGTCACCTGAATCTGGTAACCACAGTACAAGTGTGCAGAGCTGGGCCTTCATTCCACAGGAC
ATAATGCATGGGCAATATAATGTTCTACAGAAAGATCATGCCAAGACCAGTGATCCAGGAAGATCATGGAAAATAATGCACATCAGTGAA
CAAGAGGAACCCATAGAGCTTAAATGTGTGTCTGTGACAGGATTCACTGCACTGTTTACTTGGGAAGTGGAAAGGATGGGCTATACCATT
ACCCTCTGGGATTTGGAGACCCAGGGCATGCAGTGTTTTTCCCTTGGCACAAAGTGTATTCCTGTAGACAGTAGTGGAGACCAGCAGCTG
TGCTTTGTTTTGACAGAGAATGGACTCTCTCTGATTTTGTTTGGTTTGACTCAAGAAGAGTTTTTAAACAGACTCATGATCCATGGAAGT
GCCAGCACTGTGGACACTCTTTGTCATCTCAATGGCTGGGGAAGGTGCTCAATTCCCATACATGCACTAGAGGCCGGGATAGAAAATCGT
CAGCTGGACACAGTAAATTTCTTTTTGAAGAGCAAGGAAAATCTTTTTAATCCATCCTCAAAATCTTCTGTATCTGATCAGTTTGATCAC
TTGTCATCCCATTTATATTTAAGAAATGTGGAAGAGCTGATACCAGCATTGGATTTACTTTGCTCGGCAATTAGAGAAAGTTATTCTGAA
CCCCAAAGCAAACACTTTTCAGAACAATTGCTTAATCTTACACTGTCTTTCCTTAACAACCAAATAAAGGAGCTTTTCATTCACACTGAA
GAACTAGATGAACATCTGCAAAAAGGAGTGAACATTTTGACTAGCTACATTAATGAACTTCGAACCTTCATGATAAAGTTTCCTTGGAAG
CTAACAGATGCTATAGATGAATATGATGTACATGAAAATGTCCCCAAAGTAAAGGAGAGCAATATATGGAAGAAACTCAGCTTTGAGGAA
GTTATTGCCAGCGCCATTTTAAACAACAAAATACCAGAGGCACAGACTTTCTTCAGGATTGATAGTCATTCTGCTCAAAAACTTGAGGAG
CTTATTGGCATAGGCCTAAATTTGGTCTTTGACAATTTAAAAAAGAACAATATAAAGGAAGCCTCTGAACTTTTGAAGAATATGGGGTTT
GATGTAAAAGGCCAATTGCTCAAGATCTGCTTCTATACAACTAATAAAAATATACGTGACTTTTTGGTTGAAATTTTAAAAGAAAAAAAT
TATTTTTCTGAAAAAGAGAAAAGAACTATAGACTTCGTGCATCAAGTTGAGAAGCTTTATTTGGGACATTTCCAAGAAAATATGCAAATC
CAGTCATTTCCCAGGTACTGGATAAAGGAACAAGATTTTTTCAAGCACAAGTCTGTTTTGGACTCATTCCTGAAATATGATTGTAAAGAT
GAATTTAACAAACAGGACCATAGAATTGTGTTAAATTGGGCTCTGTGGTGGGATCAACTAACACAAGAATCCATCCTTCTCCCCAGGATA
AGTCCAGAAGAATACAAATCATATTCCCCTGAAGCCCTCTGGAGATACCTCACAGCTCGCCATGATTGGTTAAACATTATCTTATGGATT
GGAGAATTTCAAACCCAGCATAGTTATGCTTCACTTCAGCAGAACAAATGGCCCCTTCTGACTGTTGATGTTATTAACCAGAATACTTCC
TGTAACAACTACATGAGGAATGAAATTTTAGATAAGCTGGCCAGGAATGGGGTTTTTTTGGCATCTGAACTGGAAGACTTTGAATGCTTC
CTCCTAAGACTGAGCCGTATTGGAGGTGTAATACAGGATACCCTCCCTGTTCAAAACTACAAGACCAAAGAAGGTTGGGATTTCCATTCT
CAATTCATTCTCTATTGTTTGGAGCACAGTCTGCAGCATCTTCTTTATGTCTACCTTGACTGTTACAAACTTAGTCCTGAAAATTGTCCC
TTTTTGGAAAAAAAAGAGTTACATGAAGCACACCCTTGGTTTGAATTTTTAGTTCAGTGTCGACAAGTTGCCAGTAACTTAACAGATCCC
AAACTGATCTTCCAGGCTAGCCTTGCAAATGCTCAGATTTTGATTCCCACCAATCAGGCCAGTGTAAGCAGTATGCTATTGGAAGGACAT
ACCCTCCTGGCCCTTGCTACTACAATGTATTCTCCTGGGGGTGTCAGTCAGGTTGTTCAGAATGAAGAAAATGAAAACTGTTTGAAGAAA
GTGGATCCCCAGCTATTGAAGATGGCATTAACTCCTTACCCCAAGCTAAAAACTGCTCTCTTCCCACAGTGCACTCCTCCTAGTGTCCTG
CCATCTGATATTACAATCTACCACCTTATTCAGTCATTATCACCCTTTGATCCTAGCAGATTGTTTGGCTGGCAGTCTGCTAACACACTA
GCTATAGGAGATGCATGGAGTCATCTCCCACATTTCTCTAGCCCTGACCTGGTTAATAAATATGCTATAGTGGAACGTCTGAATTTTGCT
TATTATTTACATAATGGGCGGCCATCATTTGCATTTGGTACTTTTCTGGTCCAGGAATTAATCAAGAGCAAGACTCCCAAGCAGCTGATC
CAGCAAGTAGGCAATGAAGCCTATGTTATAGGGCTCTCCTCCTTCCACATACCTTCAATAGGAGCTGCATGTGTTTGTTTCTTAGAATTG
CTTGGCCTTGACAGCCTCAAGCTCAGAGTTGATATGAAAGTGGCCAATATAATTTTGAGCTACAAGTGCAGAAATGAAGATGCTCAGTAC
AGCTTTATCAGAGAGTCTGTAGCCGAAAAACTATCTAAACTAGCTGATGGTGAAAAGACAACCACAGAAGAATTGCTTGTTCTCTTAGAA
GAAGGTACATGGAACAGCATTCAGCAACAGGAAATAAAGAGGTTATCCAGTGAATCTAGCAGCCAATGGGCATTAGTGGTGCAGTTCTGC
AGGCTACACAATATGAAACTAAGCATATCTTACCTTAGAGAATGTGCCAAAGCAAATGATTGGCTGCAGTTCATTATTCACAGCCAACTC
CACAACTACCACCCAGCAGAGGTGAAATCCCTTATCCAGTACTTCAGCCCAGTCATTCAAGACCACTTAAGGCTGGCTTTTGAGAACTTG
CCCTCAGTGCCCACCTCCAAAATGGACAGCGATCAAGTCTGCAATAAGTGCCCCCAGGAACTTCAAGGAAGCAAACAAGAGATGACCGAT
TTATTTGAAATTCTGCTCCAATGCTCAGAGGAGCCAGACTCCTGGCACTGGCTTCTGGTTGAAGCAGTGAAACAACAGGCCCCTATCCTC
AGTGTTCTGGCCTCATGTCTCCAGGGTGCCAGTGCCATTTCTTGTCTCTGTGTTTGGATCATCACTTCTGTGGAGGACAATGTTGCAACT
GAAGCAATGGGACACATTCAGGACTCAACAGAGGACCATACCTGGAACCTTGAGGATCTTTCAGTCATCTGGAGAACATTATTAACAAGA
CAAAAGAGCAAAACTCTCATCAGAGGTTTCCAGCTTTTCTTTAAGGATTCCCCGTTACTACTGGTGATGGAGATGTATGAACTGTGTATG
TTCTTCAGGAATTATAAAGAAGCTGAAGCTAAACTTCTGGAGTTTCAGAAGAGCCTTGAAACGCTTAACACAGCAGCCACAAAGGTCCAC
CCTGTCATCCCTGCCATGTGGCTGGAGGATCAGGTGTGTTTCCTTTTGAAGCTTATGCTACAGCAGTGTAAGACCCAGTATGAGCTGGGG
AAGCTTTTACAGCTCTTTGTTGAAAGAGAGCATCTCTTCTCTGATGAGCTCTGCGTGCCTCTTGCTGTGCCCTACCTGGACAAACCCCCA
ACTCCGCTCCACTTCTACCGGGACTGGGTCTGCCCCAACAGGCCGTGCATTATCCGCAACGCTCTGCAGCACTGGCCGGCCCTCCAGAAG
TGGTCCCTCCCCTATTTCAGAGCCACAGTGGGCTCCACAGAGGTGAGTGTGGCCGTGACCCCAGATGGTTACGCGGATGCCGTGAGAGGG
GATCGCTTCATGATGCCAGCTGAGCGCCGCCTGCCCCTGAGCTTCGTGCTGGATGTGCTGGAGGGCCGGGCCCAGCACCCTGGAGTCCTC
TATGTGCAGAAGCAGTGCTCCAACCTGCCCAGCGAGCTGCCCCAGCTGCTGCCTGATCTGGAATCCCATGTGCCCTGGGCCTCCGAAGCC
CTGGGAAAGATGCCCGATGCTGTGAACTTCTGGCTGGGGGAGGCGGCTGCAGTGACTTCTTTGCACAAGGACCACTATGAGAACCTCTAC
TGCGTGGTCTCAGGAGAGAAGCATTTCCTGTTCCATCCGCCCAGCGACCGGCCCTTCATCCCCTATGAGCTGTACACGCCGGCAACCTAC
CAGCTAACTGAAGAGGGCACCTTTAAGGTGGTGGATGAAGAGGCCATGGAGAAGGTGCCCTGGATCCCACTGGACCCCTTGGCGCCAGAC
CTAGCACGGTACCCTAGTTACAGTCAGGCCCAGGCCCTTCGCTGCACGGTGCGGGCCGGTGAGATGCTCTATCTGCCGGCTCTGTGGTTC
CACCACGTCCAGCAGTCCCAGGGCTGCATCGCAGTGAATTTCTGGTATGACATGGAATACGACCTCAAGTATAGTTACTTCCAGCTGCTC
GACTCCCTCACCAAGGCTTCAGGCCTTGACTGATGGAGCACTGGTGAACACCACCAAGCACGCCTCGGGGGACGGAGCCAGCCCCTCCCT
GGCCAGGTCAATTCTCGAGAGAGCCTGGAGTGTGCATGCTGGCTGCTGGCCCCGGGTCCAGCATGGCTTGAGATCAGCTTTGGAGGATCT
TGGAATGTGGTCATAAGGACTCAAGGTGCCAGGCAGGTCTGGGTGAGGGTTCTCAGGAAGTTGCCACACAGGTGAGCAGAGTGGGGATCA
GGTGCAGCGGCACCTCTCCCCAGCGCTGTGATGTTGGGCGAGTCACTGCGTCTCGGGCATTGGTGTCCTGTCAGTAAAGAGATAATAATG
GCTGTACCTCGCGGGGCTGTTGTGGGCTTGGAGATGATGTCTATGAGGACCAGCATGGAGCTGGCACACAGGACATGTTGAATAAAAGGT

>85740_85740_2_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000427534_JMJD7_chr15_42126938_ENST00000397299_length(amino acids)=1930AA_BP=1635
MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSRAQLRTQPEALGSLTAAGSLQVLSLTPGSRGGGRCCLEGPFWHFLWE
DSRNSSTPTEKPKLLALGENYELLIYEFNLKDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFHNNTSLLFINKCVILHIIFPE
RDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSSLGWIYIFDVVDGTYVAHVDLALHKEDMCNEQQQEPAKISSFTSLKVSQDLDV
AVIVSSSNSAVALNLNLYFRQHPGHLLCERILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQIDRSWKAQLSSLNETIKNSKLEVSCCA
PWFQDILHLESPESGNHSTSVQSWAFIPQDIMHGQYNVLQKDHAKTSDPGRSWKIMHISEQEEPIELKCVSVTGFTALFTWEVERMGYTI
TLWDLETQGMQCFSLGTKCIPVDSSGDQQLCFVLTENGLSLILFGLTQEEFLNRLMIHGSASTVDTLCHLNGWGRCSIPIHALEAGIENR
QLDTVNFFLKSKENLFNPSSKSSVSDQFDHLSSHLYLRNVEELIPALDLLCSAIRESYSEPQSKHFSEQLLNLTLSFLNNQIKELFIHTE
ELDEHLQKGVNILTSYINELRTFMIKFPWKLTDAIDEYDVHENVPKVKESNIWKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEE
LIGIGLNLVFDNLKKNNIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKNYFSEKEKRTIDFVHQVEKLYLGHFQENMQI
QSFPRYWIKEQDFFKHKSVLDSFLKYDCKDEFNKQDHRIVLNWALWWDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWI
GEFQTQHSYASLQQNKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECFLLRLSRIGGVIQDTLPVQNYKTKEGWDFHS
QFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHEAHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGH
TLLALATTMYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITIYHLIQSLSPFDPSRLFGWQSANTL
AIGDAWSHLPHFSSPDLVNKYAIVERLNFAYYLHNGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLEL
LGLDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLEEGTWNSIQQQEIKRLSSESSSQWALVVQFC
RLHNMKLSISYLRECAKANDWLQFIIHSQLHNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQEMTD
LFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQGASAISCLCVWIITSVEDNVATEAMGHIQDSTEDHTWNLEDLSVIWRTLLTR
QKSKTLIRGFQLFFKDSPLLLVMEMYELCMFFRNYKEAEAKLLEFQKSLETLNTAATKVHPVIPAMWLEDQVCFLLKLMLQQCKTQYELG
KLLQLFVEREHLFSDELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRG
DRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLY
CVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWF

--------------------------------------------------------------
>85740_85740_3_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000535302_JMJD7_chr15_42126938_ENST00000397299_length(transcript)=6246nt_BP=4934nt
AGTGACCGGAAGTAACCGCCGGGCCAAGATGGCTGCAGAGGAAGGGGTCGCGAGTGCTGCTTCCGCCGGCGGTAGCTGGGGCACCGCGGC
CATGGGGCGGGTTCTACCGATGCTGTTGGTGCCAGTCCCCGCCGAGGCGATGGGGCAGCTCGGCTCCCGGGCGCAGCTGCGCACACAGCC
GGAGGCTCTGGGGAGCCTGACGGCTGCGGGCAGCCTCCAAGTGCTTTCTTTGACGCCTGGCAGCCGGGGCGGGGGTCGCTGCTGCCTGGA
GGGCCCCTTCTGGCACTTTCTATGGGAGGATTCTCGTAACAGCAGCACACCAACTGAAAAGCCCAAACTGCTCGCTCTTGGTGAAAATTA
TGAACTGCTTATCTATGAATTTAATTTGAAAGATGGAAGATGTGATGCAACCATTTTGTATAGCTGTAGTAGGGAGGCATTGCAAAAGCT
CATTGACGATCAAGATATCAGTATTTCCTTATTGTCTTTGAGAATCCTGTCATTTCACAATAACACATCATTACTGTTCATCAACAAATG
TGTCATCCTACATATTATATTTCCTGAAAGAGATGCTGCAATTAGAGTACTCAACTGTTTCACACTTCCCTTGCCTGCACAGGCAGTGGA
CATGATTATTGACACGCAGCTCTGCAGAGGAATTCTTTTTGTTTTGAGTAGTTTAGGCTGGATCTACATTTTTGATGTTGTGGATGGTAC
ATATGTAGCTCATGTGGATTTAGCACTTCACAAAGAAGACATGTGTAATGAGCAGCAACAGGAGCCAGCCAAGATTTCTTCATTTACTTC
ACTGAAAGTTTCTCAAGACCTCGATGTTGCAGTGATTGTCAGCTCCTCCAACTCCGCAGTTGCTCTTAACTTAAATTTGTATTTCAGGCA
ACACCCAGGACACCTACTGTGTGAAAGAATACTAGAAGATCTTCCTATTCAAGGACCTAAGGGCGTAGATGAAGATGATCCTGTTAACTC
TGCCTACAACATGAAACTGGCCAAGTTTTCCTTCCAAATTGATAGGTCTTGGAAAGCCCAGCTATCATCATTGAATGAAACAATAAAGAA
CTCCAAACTGGAGGTTTCCTGTTGTGCTCCATGGTTCCAGGATATTTTGCATTTGGAGTCACCTGAATCTGGTAACCACAGTACAAGTGT
GCAGAGCTGGGCCTTCATTCCACAGGACATAATGCATGGGCAATATAATGTTCTACAGAAAGATCATGCCAAGACCAGTGATCCAGGAAG
ATCATGGAAAATAATGCACATCAGTGAACAAGAGGAACCCATAGAGCTTAAATGTGTGTCTGTGACAGGATTCACTGCACTGTTTACTTG
GGAAGTGGAAAGGATGGGCTATACCATTACCCTCTGGGATTTGGAGACCCAGGGCATGCAGTGTTTTTCCCTTGGCACAAAGTGTATTCC
TGTAGACAGTAGTGGAGACCAGCAGCTGTGCTTTGTTTTGACAGAGAATGGACTCTCTCTGATTTTGTTTGGTTTGACTCAAGAAGAGTT
TTTAAACAGACTCATGATCCATGGAAGTGCCAGCACTGTGGACACTCTTTGTCATCTCAATGGCTGGGGAAGGTGCTCAATTCCCATACA
TGCACTAGAGGCCGGGATAGAAAATCGTCAGCTGGACACAGTAAATTTCTTTTTGAAGAGCAAGGAAAATCTTTTTAATCCATCCTCAAA
ATCTTCTGTATCTGATCAGTTTGATCACTTGTCATCCCATTTATATTTAAGAAATGTGGAAGAGCTGATACCAGCATTGGATTTACTTTG
CTCGGCAATTAGAGAAAGTTATTCTGAACCCCAAAGCAAACACTTTTCAGAACAATTGCTTAATCTTACACTGTCTTTCCTTAACAACCA
AATAAAGGAGCTTTTCATTCACACTGAAGAACTAGATGAACATCTGCAAAAAGGAGTGAACATTTTGACTAGCTACATTAATGAACTTCG
AACCTTCATGATAAAGTTTCCTTGGAAGCTAACAGATGCTATAGATGAATATGATGTACATGAAAATGTCCCCAAAGTAAAGGAGAGCAA
TATATGGAAGAAACTCAGCTTTGAGGAAGTTATTGCCAGCGCCATTTTAAACAACAAAATACCAGAGGCACAGACTTTCTTCAGGATTGA
TAGTCATTCTGCTCAAAAACTTGAGGAGCTTATTGGCATAGGCCTAAATTTGGTCTTTGACAATTTAAAAAAGAACAATATAAAGGAAGC
CTCTGAACTTTTGAAGAATATGGGGTTTGATGTAAAAGGCCAATTGCTCAAGATCTGCTTCTATACAACTAATAAAAATATACGTGACTT
TTTGGTTGAAATTTTAAAAGAAAAAAATTATTTTTCTGAAAAAGAGAAAAGAACTATAGACTTCGTGCATCAAGTTGAGAAGCTTTATTT
GGGACATTTCCAAGAAAATATGCAAATCCAGTCATTTCCCAGGTACTGGATAAAGGAACAAGATTTTTTCAAGCACAAGTCTGTTTTGGA
CTCATTCCTGAAATATGATTGTAAAGATGAATTTAACAAACAGGACCATAGAATTGTGTTAAATTGGGCTCTGTGGTGGGATCAACTAAC
ACAAGAATCCATCCTTCTCCCCAGGATAAGTCCAGAAGAATACAAATCATATTCCCCTGAAGCCCTCTGGAGATACCTCACAGCTCGCCA
TGATTGGTTAAACATTATCTTATGGATTGGAGAATTTCAAACCCAGCATAGTTATGCTTCACTTCAGCAGAACAAATGGCCCCTTCTGAC
TGTTGATGTTATTAACCAGAATACTTCCTGTAACAACTACATGAGGAATGAAATTTTAGATAAGCTGGCCAGGAATGGGGTTTTTTTGGC
ATCTGAACTGGAAGACTTTGAATGCTTCCTCCTAAGACTGAGCCGTATTGGAGGTGTAATACAGGATACCCTCCCTGTTCAAAACTACAA
GACCAAAGAAGGTTGGGATTTCCATTCTCAATTCATTCTCTATTGTTTGGAGCACAGTCTGCAGCATCTTCTTTATGTCTACCTTGACTG
TTACAAACTTAGTCCTGAAAATTGTCCCTTTTTGGAAAAAAAAGAGTTACATGAAGCACACCCTTGGTTTGAATTTTTAGTTCAGTGTCG
ACAAGTTGCCAGTAACTTAACAGATCCCAAACTGATCTTCCAGGCTAGCCTTGCAAATGCTCAGATTTTGATTCCCACCAATCAGGCCAG
TGTAAGCAGTATGCTATTGGAAGGACATACCCTCCTGGCCCTTGCTACTACAATGTATTCTCCTGGGGGTGTCAGTCAGGTTGTTCAGAA
TGAAGAAAATGAAAACTGTTTGAAGAAAGTGGATCCCCAGCTATTGAAGATGGCATTAACTCCTTACCCCAAGCTAAAAACTGCTCTCTT
CCCACAGTGCACTCCTCCTAGTGTCCTGCCATCTGATATTACAATCTACCACCTTATTCAGTCATTATCACCCTTTGATCCTAGCAGATT
GTTTGGCTGGCAGTCTGCTAACACACTAGCTATAGGAGATGCATGGAGTCATCTCCCACATTTCTCTAGCCCTGACCTGGTTAATAAATA
TGCTATAGTGGAACGTCTGAATTTTGCTTATTATTTACATAATGGGCGGCCATCATTTGCATTTGGTACTTTTCTGGTCCAGGAATTAAT
CAAGAGCAAGACTCCCAAGCAGCTGATCCAGCAAGTAGGCAATGAAGCCTATGTTATAGGGCTCTCCTCCTTCCACATACCTTCAATAGG
AGCTGCATGTGTTTGTTTCTTAGAATTGCTTGGCCTTGACAGCCTCAAGCTCAGAGTTGATATGAAAGTGGCCAATATAATTTTGAGCTA
CAAGTGCAGAAATGAAGATGCTCAGTACAGCTTTATCAGAGAGTCTGTAGCCGAAAAACTATCTAAACTAGCTGATGGTGAAAAGACAAC
CACAGAAGAATTGCTTGTTCTCTTAGAAGAAGGTACATGGAACAGCATTCAGCAACAGGAAATAAAGAGGTTATCCAGTGAATCTAGCAG
CCAATGGGCATTAGTGGTGCAGTTCTGCAGGCTACACAATATGAAACTAAGCATATCTTACCTTAGAGAATGTGCCAAAGCAAATGATTG
GCTGCAGTTCATTATTCACAGCCAACTCCACAACTACCACCCAGCAGAGGTGAAATCCCTTATCCAGTACTTCAGCCCAGTCATTCAAGA
CCACTTAAGGCTGGCTTTTGAGAACTTGCCCTCAGTGCCCACCTCCAAAATGGACAGCGATCAAGTCTGCAATAAGTGCCCCCAGGAACT
TCAAGGAAGCAAACAAGAGATGACCGATTTATTTGAAATTCTGCTCCAATGCTCAGAGGAGCCAGACTCCTGGCACTGGCTTCTGGTTGA
AGCAGTGAAACAACAGGCCCCTATCCTCAGTGTTCTGGCCTCATGTCTCCAGGGTGCCAGTGCCATTTCTTGTCTCTGTGTTTGGATCAT
CACTTCTGTGGAGGACAATGTTGCAACTGAAGCAATGGGACACATTCAGGACTCAACAGAGGACCATACCTGGAACCTTGAGGATCTTTC
AGTCATCTGGAGAACATTATTAACAAGACAAAAGAGCAAAACTCTCATCAGAGGTTTCCAGCTTTTCTTTAAGGATTCCCCGTTACTACT
GGTGATGGAGATGTATGAACTGTGTATGTTCTTCAGGAATTATAAAGAAGCTGAAGCTAAACTTCTGGAGTTTCAGAAGAGCCTTGAAAC
GCTTAACACAGCAGCCACAAAGGTCCACCCTGTCATCCCTGCCATGTGGCTGGAGGATCAGGTGTGTTTCCTTTTGAAGCTTATGCTACA
GCAGTGTAAGACCCAGTATGAGCTGGGGAAGCTTTTACAGCTCTTTGTTGAAAGAGAGCATCTCTTCTCTGATGAGCTCTGCGTGCCTCT
TGCTGTGCCCTACCTGGACAAACCCCCAACTCCGCTCCACTTCTACCGGGACTGGGTCTGCCCCAACAGGCCGTGCATTATCCGCAACGC
TCTGCAGCACTGGCCGGCCCTCCAGAAGTGGTCCCTCCCCTATTTCAGAGCCACAGTGGGCTCCACAGAGGTGAGTGTGGCCGTGACCCC
AGATGGTTACGCGGATGCCGTGAGAGGGGATCGCTTCATGATGCCAGCTGAGCGCCGCCTGCCCCTGAGCTTCGTGCTGGATGTGCTGGA
GGGCCGGGCCCAGCACCCTGGAGTCCTCTATGTGCAGAAGCAGTGCTCCAACCTGCCCAGCGAGCTGCCCCAGCTGCTGCCTGATCTGGA
ATCCCATGTGCCCTGGGCCTCCGAAGCCCTGGGAAAGATGCCCGATGCTGTGAACTTCTGGCTGGGGGAGGCGGCTGCAGTGACTTCTTT
GCACAAGGACCACTATGAGAACCTCTACTGCGTGGTCTCAGGAGAGAAGCATTTCCTGTTCCATCCGCCCAGCGACCGGCCCTTCATCCC
CTATGAGCTGTACACGCCGGCAACCTACCAGCTAACTGAAGAGGGCACCTTTAAGGTGGTGGATGAAGAGGCCATGGAGAAGGTGCCCTG
GATCCCACTGGACCCCTTGGCGCCAGACCTAGCACGGTACCCTAGTTACAGTCAGGCCCAGGCCCTTCGCTGCACGGTGCGGGCCGGTGA
GATGCTCTATCTGCCGGCTCTGTGGTTCCACCACGTCCAGCAGTCCCAGGGCTGCATCGCAGTGAATTTCTGGTATGACATGGAATACGA
CCTCAAGTATAGTTACTTCCAGCTGCTCGACTCCCTCACCAAGGCTTCAGGCCTTGACTGATGGAGCACTGGTGAACACCACCAAGCACG
CCTCGGGGGACGGAGCCAGCCCCTCCCTGGCCAGGTCAATTCTCGAGAGAGCCTGGAGTGTGCATGCTGGCTGCTGGCCCCGGGTCCAGC
ATGGCTTGAGATCAGCTTTGGAGGATCTTGGAATGTGGTCATAAGGACTCAAGGTGCCAGGCAGGTCTGGGTGAGGGTTCTCAGGAAGTT
GCCACACAGGTGAGCAGAGTGGGGATCAGGTGCAGCGGCACCTCTCCCCAGCGCTGTGATGTTGGGCGAGTCACTGCGTCTCGGGCATTG
GTGTCCTGTCAGTAAAGAGATAATAATGGCTGTACCTCGCGGGGCTGTTGTGGGCTTGGAGATGATGTCTATGAGGACCAGCATGGAGCT

>85740_85740_3_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000535302_JMJD7_chr15_42126938_ENST00000397299_length(amino acids)=1930AA_BP=1635
MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSRAQLRTQPEALGSLTAAGSLQVLSLTPGSRGGGRCCLEGPFWHFLWE
DSRNSSTPTEKPKLLALGENYELLIYEFNLKDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFHNNTSLLFINKCVILHIIFPE
RDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSSLGWIYIFDVVDGTYVAHVDLALHKEDMCNEQQQEPAKISSFTSLKVSQDLDV
AVIVSSSNSAVALNLNLYFRQHPGHLLCERILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQIDRSWKAQLSSLNETIKNSKLEVSCCA
PWFQDILHLESPESGNHSTSVQSWAFIPQDIMHGQYNVLQKDHAKTSDPGRSWKIMHISEQEEPIELKCVSVTGFTALFTWEVERMGYTI
TLWDLETQGMQCFSLGTKCIPVDSSGDQQLCFVLTENGLSLILFGLTQEEFLNRLMIHGSASTVDTLCHLNGWGRCSIPIHALEAGIENR
QLDTVNFFLKSKENLFNPSSKSSVSDQFDHLSSHLYLRNVEELIPALDLLCSAIRESYSEPQSKHFSEQLLNLTLSFLNNQIKELFIHTE
ELDEHLQKGVNILTSYINELRTFMIKFPWKLTDAIDEYDVHENVPKVKESNIWKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEE
LIGIGLNLVFDNLKKNNIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKNYFSEKEKRTIDFVHQVEKLYLGHFQENMQI
QSFPRYWIKEQDFFKHKSVLDSFLKYDCKDEFNKQDHRIVLNWALWWDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWI
GEFQTQHSYASLQQNKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECFLLRLSRIGGVIQDTLPVQNYKTKEGWDFHS
QFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHEAHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGH
TLLALATTMYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITIYHLIQSLSPFDPSRLFGWQSANTL
AIGDAWSHLPHFSSPDLVNKYAIVERLNFAYYLHNGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLEL
LGLDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLEEGTWNSIQQQEIKRLSSESSSQWALVVQFC
RLHNMKLSISYLRECAKANDWLQFIIHSQLHNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQEMTD
LFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQGASAISCLCVWIITSVEDNVATEAMGHIQDSTEDHTWNLEDLSVIWRTLLTR
QKSKTLIRGFQLFFKDSPLLLVMEMYELCMFFRNYKEAEAKLLEFQKSLETLNTAATKVHPVIPAMWLEDQVCFLLKLMLQQCKTQYELG
KLLQLFVEREHLFSDELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRG
DRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLY
CVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWF

--------------------------------------------------------------
>85740_85740_4_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000558319_JMJD7_chr15_42126938_ENST00000397299_length(transcript)=6249nt_BP=4937nt
GAAAGTGACCGGAAGTAACCGCCGGGCCAAGATGGCTGCAGAGGAAGGGGTCGCGAGTGCTGCTTCCGCCGGCGGTAGCTGGGGCACCGC
GGCCATGGGGCGGGTTCTACCGATGCTGTTGGTGCCAGTCCCCGCCGAGGCGATGGGGCAGCTCGGCTCCCGGGCGCAGCTGCGCACACA
GCCGGAGGCTCTGGGGAGCCTGACGGCTGCGGGCAGCCTCCAAGTGCTTTCTTTGACGCCTGGCAGCCGGGGCGGGGGTCGCTGCTGCCT
GGAGGGCCCCTTCTGGCACTTTCTATGGGAGGATTCTCGTAACAGCAGCACACCAACTGAAAAGCCCAAACTGCTCGCTCTTGGTGAAAA
TTATGAACTGCTTATCTATGAATTTAATTTGAAAGATGGAAGATGTGATGCAACCATTTTGTATAGCTGTAGTAGGGAGGCATTGCAAAA
GCTCATTGACGATCAAGATATCAGTATTTCCTTATTGTCTTTGAGAATCCTGTCATTTCACAATAACACATCATTACTGTTCATCAACAA
ATGTGTCATCCTACATATTATATTTCCTGAAAGAGATGCTGCAATTAGAGTACTCAACTGTTTCACACTTCCCTTGCCTGCACAGGCAGT
GGACATGATTATTGACACGCAGCTCTGCAGAGGAATTCTTTTTGTTTTGAGTAGTTTAGGCTGGATCTACATTTTTGATGTTGTGGATGG
TACATATGTAGCTCATGTGGATTTAGCACTTCACAAAGAAGACATGTGTAATGAGCAGCAACAGGAGCCAGCCAAGATTTCTTCATTTAC
TTCACTGAAAGTTTCTCAAGACCTCGATGTTGCAGTGATTGTCAGCTCCTCCAACTCCGCAGTTGCTCTTAACTTAAATTTGTATTTCAG
GCAACACCCAGGACACCTACTGTGTGAAAGAATACTAGAAGATCTTCCTATTCAAGGACCTAAGGGCGTAGATGAAGATGATCCTGTTAA
CTCTGCCTACAACATGAAACTGGCCAAGTTTTCCTTCCAAATTGATAGGTCTTGGAAAGCCCAGCTATCATCATTGAATGAAACAATAAA
GAACTCCAAACTGGAGGTTTCCTGTTGTGCTCCATGGTTCCAGGATATTTTGCATTTGGAGTCACCTGAATCTGGTAACCACAGTACAAG
TGTGCAGAGCTGGGCCTTCATTCCACAGGACATAATGCATGGGCAATATAATGTTCTACAGAAAGATCATGCCAAGACCAGTGATCCAGG
AAGATCATGGAAAATAATGCACATCAGTGAACAAGAGGAACCCATAGAGCTTAAATGTGTGTCTGTGACAGGATTCACTGCACTGTTTAC
TTGGGAAGTGGAAAGGATGGGCTATACCATTACCCTCTGGGATTTGGAGACCCAGGGCATGCAGTGTTTTTCCCTTGGCACAAAGTGTAT
TCCTGTAGACAGTAGTGGAGACCAGCAGCTGTGCTTTGTTTTGACAGAGAATGGACTCTCTCTGATTTTGTTTGGTTTGACTCAAGAAGA
GTTTTTAAACAGACTCATGATCCATGGAAGTGCCAGCACTGTGGACACTCTTTGTCATCTCAATGGCTGGGGAAGGTGCTCAATTCCCAT
ACATGCACTAGAGGCCGGGATAGAAAATCGTCAGCTGGACACAGTAAATTTCTTTTTGAAGAGCAAGGAAAATCTTTTTAATCCATCCTC
AAAATCTTCTGTATCTGATCAGTTTGATCACTTGTCATCCCATTTATATTTAAGAAATGTGGAAGAGCTGATACCAGCATTGGATTTACT
TTGCTCGGCAATTAGAGAAAGTTATTCTGAACCCCAAAGCAAACACTTTTCAGAACAATTGCTTAATCTTACACTGTCTTTCCTTAACAA
CCAAATAAAGGAGCTTTTCATTCACACTGAAGAACTAGATGAACATCTGCAAAAAGGAGTGAACATTTTGACTAGCTACATTAATGAACT
TCGAACCTTCATGATAAAGTTTCCTTGGAAGCTAACAGATGCTATAGATGAATATGATGTACATGAAAATGTCCCCAAAGTAAAGGAGAG
CAATATATGGAAGAAACTCAGCTTTGAGGAAGTTATTGCCAGCGCCATTTTAAACAACAAAATACCAGAGGCACAGACTTTCTTCAGGAT
TGATAGTCATTCTGCTCAAAAACTTGAGGAGCTTATTGGCATAGGCCTAAATTTGGTCTTTGACAATTTAAAAAAGAACAATATAAAGGA
AGCCTCTGAACTTTTGAAGAATATGGGGTTTGATGTAAAAGGCCAATTGCTCAAGATCTGCTTCTATACAACTAATAAAAATATACGTGA
CTTTTTGGTTGAAATTTTAAAAGAAAAAAATTATTTTTCTGAAAAAGAGAAAAGAACTATAGACTTCGTGCATCAAGTTGAGAAGCTTTA
TTTGGGACATTTCCAAGAAAATATGCAAATCCAGTCATTTCCCAGGTACTGGATAAAGGAACAAGATTTTTTCAAGCACAAGTCTGTTTT
GGACTCATTCCTGAAATATGATTGTAAAGATGAATTTAACAAACAGGACCATAGAATTGTGTTAAATTGGGCTCTGTGGTGGGATCAACT
AACACAAGAATCCATCCTTCTCCCCAGGATAAGTCCAGAAGAATACAAATCATATTCCCCTGAAGCCCTCTGGAGATACCTCACAGCTCG
CCATGATTGGTTAAACATTATCTTATGGATTGGAGAATTTCAAACCCAGCATAGTTATGCTTCACTTCAGCAGAACAAATGGCCCCTTCT
GACTGTTGATGTTATTAACCAGAATACTTCCTGTAACAACTACATGAGGAATGAAATTTTAGATAAGCTGGCCAGGAATGGGGTTTTTTT
GGCATCTGAACTGGAAGACTTTGAATGCTTCCTCCTAAGACTGAGCCGTATTGGAGGTGTAATACAGGATACCCTCCCTGTTCAAAACTA
CAAGACCAAAGAAGGTTGGGATTTCCATTCTCAATTCATTCTCTATTGTTTGGAGCACAGTCTGCAGCATCTTCTTTATGTCTACCTTGA
CTGTTACAAACTTAGTCCTGAAAATTGTCCCTTTTTGGAAAAAAAAGAGTTACATGAAGCACACCCTTGGTTTGAATTTTTAGTTCAGTG
TCGACAAGTTGCCAGTAACTTAACAGATCCCAAACTGATCTTCCAGGCTAGCCTTGCAAATGCTCAGATTTTGATTCCCACCAATCAGGC
CAGTGTAAGCAGTATGCTATTGGAAGGACATACCCTCCTGGCCCTTGCTACTACAATGTATTCTCCTGGGGGTGTCAGTCAGGTTGTTCA
GAATGAAGAAAATGAAAACTGTTTGAAGAAAGTGGATCCCCAGCTATTGAAGATGGCATTAACTCCTTACCCCAAGCTAAAAACTGCTCT
CTTCCCACAGTGCACTCCTCCTAGTGTCCTGCCATCTGATATTACAATCTACCACCTTATTCAGTCATTATCACCCTTTGATCCTAGCAG
ATTGTTTGGCTGGCAGTCTGCTAACACACTAGCTATAGGAGATGCATGGAGTCATCTCCCACATTTCTCTAGCCCTGACCTGGTTAATAA
ATATGCTATAGTGGAACGTCTGAATTTTGCTTATTATTTACATAATGGGCGGCCATCATTTGCATTTGGTACTTTTCTGGTCCAGGAATT
AATCAAGAGCAAGACTCCCAAGCAGCTGATCCAGCAAGTAGGCAATGAAGCCTATGTTATAGGGCTCTCCTCCTTCCACATACCTTCAAT
AGGAGCTGCATGTGTTTGTTTCTTAGAATTGCTTGGCCTTGACAGCCTCAAGCTCAGAGTTGATATGAAAGTGGCCAATATAATTTTGAG
CTACAAGTGCAGAAATGAAGATGCTCAGTACAGCTTTATCAGAGAGTCTGTAGCCGAAAAACTATCTAAACTAGCTGATGGTGAAAAGAC
AACCACAGAAGAATTGCTTGTTCTCTTAGAAGAAGGTACATGGAACAGCATTCAGCAACAGGAAATAAAGAGGTTATCCAGTGAATCTAG
CAGCCAATGGGCATTAGTGGTGCAGTTCTGCAGGCTACACAATATGAAACTAAGCATATCTTACCTTAGAGAATGTGCCAAAGCAAATGA
TTGGCTGCAGTTCATTATTCACAGCCAACTCCACAACTACCACCCAGCAGAGGTGAAATCCCTTATCCAGTACTTCAGCCCAGTCATTCA
AGACCACTTAAGGCTGGCTTTTGAGAACTTGCCCTCAGTGCCCACCTCCAAAATGGACAGCGATCAAGTCTGCAATAAGTGCCCCCAGGA
ACTTCAAGGAAGCAAACAAGAGATGACCGATTTATTTGAAATTCTGCTCCAATGCTCAGAGGAGCCAGACTCCTGGCACTGGCTTCTGGT
TGAAGCAGTGAAACAACAGGCCCCTATCCTCAGTGTTCTGGCCTCATGTCTCCAGGGTGCCAGTGCCATTTCTTGTCTCTGTGTTTGGAT
CATCACTTCTGTGGAGGACAATGTTGCAACTGAAGCAATGGGACACATTCAGGACTCAACAGAGGACCATACCTGGAACCTTGAGGATCT
TTCAGTCATCTGGAGAACATTATTAACAAGACAAAAGAGCAAAACTCTCATCAGAGGTTTCCAGCTTTTCTTTAAGGATTCCCCGTTACT
ACTGGTGATGGAGATGTATGAACTGTGTATGTTCTTCAGGAATTATAAAGAAGCTGAAGCTAAACTTCTGGAGTTTCAGAAGAGCCTTGA
AACGCTTAACACAGCAGCCACAAAGGTCCACCCTGTCATCCCTGCCATGTGGCTGGAGGATCAGGTGTGTTTCCTTTTGAAGCTTATGCT
ACAGCAGTGTAAGACCCAGTATGAGCTGGGGAAGCTTTTACAGCTCTTTGTTGAAAGAGAGCATCTCTTCTCTGATGAGCTCTGCGTGCC
TCTTGCTGTGCCCTACCTGGACAAACCCCCAACTCCGCTCCACTTCTACCGGGACTGGGTCTGCCCCAACAGGCCGTGCATTATCCGCAA
CGCTCTGCAGCACTGGCCGGCCCTCCAGAAGTGGTCCCTCCCCTATTTCAGAGCCACAGTGGGCTCCACAGAGGTGAGTGTGGCCGTGAC
CCCAGATGGTTACGCGGATGCCGTGAGAGGGGATCGCTTCATGATGCCAGCTGAGCGCCGCCTGCCCCTGAGCTTCGTGCTGGATGTGCT
GGAGGGCCGGGCCCAGCACCCTGGAGTCCTCTATGTGCAGAAGCAGTGCTCCAACCTGCCCAGCGAGCTGCCCCAGCTGCTGCCTGATCT
GGAATCCCATGTGCCCTGGGCCTCCGAAGCCCTGGGAAAGATGCCCGATGCTGTGAACTTCTGGCTGGGGGAGGCGGCTGCAGTGACTTC
TTTGCACAAGGACCACTATGAGAACCTCTACTGCGTGGTCTCAGGAGAGAAGCATTTCCTGTTCCATCCGCCCAGCGACCGGCCCTTCAT
CCCCTATGAGCTGTACACGCCGGCAACCTACCAGCTAACTGAAGAGGGCACCTTTAAGGTGGTGGATGAAGAGGCCATGGAGAAGGTGCC
CTGGATCCCACTGGACCCCTTGGCGCCAGACCTAGCACGGTACCCTAGTTACAGTCAGGCCCAGGCCCTTCGCTGCACGGTGCGGGCCGG
TGAGATGCTCTATCTGCCGGCTCTGTGGTTCCACCACGTCCAGCAGTCCCAGGGCTGCATCGCAGTGAATTTCTGGTATGACATGGAATA
CGACCTCAAGTATAGTTACTTCCAGCTGCTCGACTCCCTCACCAAGGCTTCAGGCCTTGACTGATGGAGCACTGGTGAACACCACCAAGC
ACGCCTCGGGGGACGGAGCCAGCCCCTCCCTGGCCAGGTCAATTCTCGAGAGAGCCTGGAGTGTGCATGCTGGCTGCTGGCCCCGGGTCC
AGCATGGCTTGAGATCAGCTTTGGAGGATCTTGGAATGTGGTCATAAGGACTCAAGGTGCCAGGCAGGTCTGGGTGAGGGTTCTCAGGAA
GTTGCCACACAGGTGAGCAGAGTGGGGATCAGGTGCAGCGGCACCTCTCCCCAGCGCTGTGATGTTGGGCGAGTCACTGCGTCTCGGGCA
TTGGTGTCCTGTCAGTAAAGAGATAATAATGGCTGTACCTCGCGGGGCTGTTGTGGGCTTGGAGATGATGTCTATGAGGACCAGCATGGA

>85740_85740_4_SPG11-JMJD7_SPG11_chr15_44881450_ENST00000558319_JMJD7_chr15_42126938_ENST00000397299_length(amino acids)=1930AA_BP=1635
MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSRAQLRTQPEALGSLTAAGSLQVLSLTPGSRGGGRCCLEGPFWHFLWE
DSRNSSTPTEKPKLLALGENYELLIYEFNLKDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFHNNTSLLFINKCVILHIIFPE
RDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSSLGWIYIFDVVDGTYVAHVDLALHKEDMCNEQQQEPAKISSFTSLKVSQDLDV
AVIVSSSNSAVALNLNLYFRQHPGHLLCERILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQIDRSWKAQLSSLNETIKNSKLEVSCCA
PWFQDILHLESPESGNHSTSVQSWAFIPQDIMHGQYNVLQKDHAKTSDPGRSWKIMHISEQEEPIELKCVSVTGFTALFTWEVERMGYTI
TLWDLETQGMQCFSLGTKCIPVDSSGDQQLCFVLTENGLSLILFGLTQEEFLNRLMIHGSASTVDTLCHLNGWGRCSIPIHALEAGIENR
QLDTVNFFLKSKENLFNPSSKSSVSDQFDHLSSHLYLRNVEELIPALDLLCSAIRESYSEPQSKHFSEQLLNLTLSFLNNQIKELFIHTE
ELDEHLQKGVNILTSYINELRTFMIKFPWKLTDAIDEYDVHENVPKVKESNIWKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEE
LIGIGLNLVFDNLKKNNIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKNYFSEKEKRTIDFVHQVEKLYLGHFQENMQI
QSFPRYWIKEQDFFKHKSVLDSFLKYDCKDEFNKQDHRIVLNWALWWDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWI
GEFQTQHSYASLQQNKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECFLLRLSRIGGVIQDTLPVQNYKTKEGWDFHS
QFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHEAHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGH
TLLALATTMYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITIYHLIQSLSPFDPSRLFGWQSANTL
AIGDAWSHLPHFSSPDLVNKYAIVERLNFAYYLHNGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLEL
LGLDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLEEGTWNSIQQQEIKRLSSESSSQWALVVQFC
RLHNMKLSISYLRECAKANDWLQFIIHSQLHNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQEMTD
LFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQGASAISCLCVWIITSVEDNVATEAMGHIQDSTEDHTWNLEDLSVIWRTLLTR
QKSKTLIRGFQLFFKDSPLLLVMEMYELCMFFRNYKEAEAKLLEFQKSLETLNTAATKVHPVIPAMWLEDQVCFLLKLMLQQCKTQYELG
KLLQLFVEREHLFSDELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRG
DRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLY
CVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPG11-JMJD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPG11-JMJD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPG11-JMJD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource