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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPG7-MOB1A (FusionGDB2 ID:85761)

Fusion Gene Summary for SPG7-MOB1A

check button Fusion gene summary
Fusion gene informationFusion gene name: SPG7-MOB1A
Fusion gene ID: 85761
HgeneTgene
Gene symbol

SPG7

MOB1A

Gene ID

6687

55233

Gene nameSPG7 matrix AAA peptidase subunit, parapleginMOB kinase activator 1A
SynonymsCAR|CMAR|PGN|SPG5CC2orf6|MATS1|MOB1|MOBK1B|MOBKL1B|Mob4B
Cytomap

16q24.3

2p13.1

Type of geneprotein-codingprotein-coding
DescriptionparapleginSPG7, paraplegin matrix AAA peptidase subunitcell matrix adhesion regulatorspastic paraplegia 7 (pure and complicated autosomal recessive)spastic paraplegia 7 proteinMOB kinase activator 1AMOB1 Mps One Binder homolog AMOB1, Mps One Binder kinase activator-like 1Bmob1 alphamob1 homolog 1Bmps one binder kinase activator-like 1B
Modification date2020032020200313
UniProtAcc.

Q9H8S9

Ensembl transtripts involved in fusion geneENST00000268704, ENST00000341316, 
ENST00000565891, 		ENST00000409969, 
ENST00000497054, ENST00000396049, 
Fusion gene scores* DoF score10 X 7 X 6=4206 X 6 X 4=144
# samples 106
** MAII scorelog2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPG7 [Title/Abstract] AND MOB1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPG7(89579445)-MOB1A(74394234), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMOB1A

GO:0035329

hippo signaling

19739119


check buttonFusion gene breakpoints across SPG7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MOB1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ASPG7chr16

89579445

+MOB1Achr2

74394234

-


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Fusion Gene ORF analysis for SPG7-MOB1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000268704ENST00000409969SPG7chr16

89579445

+MOB1Achr2

74394234

-
5CDS-5UTRENST00000268704ENST00000497054SPG7chr16

89579445

+MOB1Achr2

74394234

-
5CDS-5UTRENST00000341316ENST00000409969SPG7chr16

89579445

+MOB1Achr2

74394234

-
5CDS-5UTRENST00000341316ENST00000497054SPG7chr16

89579445

+MOB1Achr2

74394234

-
In-frameENST00000268704ENST00000396049SPG7chr16

89579445

+MOB1Achr2

74394234

-
In-frameENST00000341316ENST00000396049SPG7chr16

89579445

+MOB1Achr2

74394234

-
intron-3CDSENST00000565891ENST00000396049SPG7chr16

89579445

+MOB1Achr2

74394234

-
intron-5UTRENST00000565891ENST00000409969SPG7chr16

89579445

+MOB1Achr2

74394234

-
intron-5UTRENST00000565891ENST00000497054SPG7chr16

89579445

+MOB1Achr2

74394234

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268704SPG7chr1689579445+ENST00000396049MOB1Achr274394234-490139115860281
ENST00000341316SPG7chr1689579445+ENST00000396049MOB1Achr274394234-48933837852281

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268704ENST00000396049SPG7chr1689579445+MOB1Achr274394234-0.0003548640.9996451
ENST00000341316ENST00000396049SPG7chr1689579445+MOB1Achr274394234-0.0003521780.99964786

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Fusion Genomic Features for SPG7-MOB1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPG7-MOB1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:89579445/chr2:74394234)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MOB1A

Q9H8S9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPG7chr16:89579445chr2:74394234ENST00000268704+317349_357125796.0Nucleotide bindingATP
HgeneSPG7chr16:89579445chr2:74394234ENST00000341316+310349_357125490.0Nucleotide bindingATP
HgeneSPG7chr16:89579445chr2:74394234ENST00000268704+317106_144125796.0Topological domainMitochondrial matrix
HgeneSPG7chr16:89579445chr2:74394234ENST00000268704+317166_248125796.0Topological domainMitochondrial intermembrane
HgeneSPG7chr16:89579445chr2:74394234ENST00000268704+317270_795125796.0Topological domainMitochondrial matrix
HgeneSPG7chr16:89579445chr2:74394234ENST00000341316+310106_144125490.0Topological domainMitochondrial matrix
HgeneSPG7chr16:89579445chr2:74394234ENST00000341316+310166_248125490.0Topological domainMitochondrial intermembrane
HgeneSPG7chr16:89579445chr2:74394234ENST00000341316+310270_795125490.0Topological domainMitochondrial matrix
HgeneSPG7chr16:89579445chr2:74394234ENST00000268704+317145_165125796.0TransmembraneHelical
HgeneSPG7chr16:89579445chr2:74394234ENST00000268704+317249_269125796.0TransmembraneHelical
HgeneSPG7chr16:89579445chr2:74394234ENST00000341316+310145_165125490.0TransmembraneHelical
HgeneSPG7chr16:89579445chr2:74394234ENST00000341316+310249_269125490.0TransmembraneHelical


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Fusion Gene Sequence for SPG7-MOB1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85761_85761_1_SPG7-MOB1A_SPG7_chr16_89579445_ENST00000268704_MOB1A_chr2_74394234_ENST00000396049_length(transcript)=4901nt_BP=391nt
GGCTTTCAGGCCAACATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCA
GGCCCGGCCTGGAGTCCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCT
GGAGGCCGAGCTCTGCAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTT
CAGAATCCAGTCAGACTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAG
TCGAAGGGGAAGGCGCCTGAAGAGGACGAAGCTGTGGATTTCTTTAACCAGATCAACATGTTATATGGAACTATTACAGAATTCTGCACT
GAAGCAAGCTGTCCAGTCATGTCTGCAGGTCCGAGATATGAATATCACTGGGCAGATGGTACTAATATTAAAAAGCCAATCAAATGTTCT
GCACCAAAATACATTGACTATTTGATGACTTGGGTTCAAGATCAGCTTGATGATGAAACTCTTTTTCCTTCTAAGATTGGTGTCCCATTT
CCCAAAAACTTTATGTCTGTGGCAAAGACTATTCTAAAGCGTCTGTTCAGGGTTTATGCCCATATTTATCACCAGCACTTTGATTCTGTG
ATGCAGCTGCAAGAGGAGGCCCACCTCAACACCTCCTTTAAGCACTTTATTTTCTTTGTTCAGGAGTTTAATCTGATTGATAGGCGTGAG
CTGGCACCTCTTCAAGAATTAATAGAGAAACTTGGATCAAAAGACAGATAAATGTTTCTTCTAGAACACAGTTACCCCCTTGCTTCATCT
ATTGCTAGAACTATCTCATTGCTATCTGTTATAGACTAGTGATACAAACTTTAAGAAAACAGGATAAAAAGATACCCATTGCCTGTGTCT
ACTGATAAAATTATCCCAAAGGTAGGTTGGTGTGATAGTTTCCGAGTAAGACCTTAAGGACACAGCCAAATCTTAAGTACTGTGTGACCA
CTCTTGTTGTTATCACATAGTCATACTTGGTTGTAATATGTGATGGTTAACCTGTAGCTTATAAATTTACTTATTATTCTTTTACTCATT
TACTCAGTCATTTCTTTACAAGAAAATGATTGAATCTGTTTTAGGTGACAGCACAATGGACATTAAGAATTTCCATCAATAATTTATGAA
TAAGTTTCCAGAACAAATTTCCTAATAACACAATCAGATTGGTTTTATTCTTTTATTTTACGAATAAAAAATGTATTTTTCAGTATCCTT
GAGATTTAGAACATCTGTGTCACTTCAGATAACATTTTAGTTTCAAGTTTGTATGGTAGTGTTTTTATAGATAAGATACGTCTATTTTTT
CAAAATTCATGATTGCAGTTTAAATCATCATATGACGTGTGGGTGGGAGCAACCAAAGTTATTTTTACAGGGACTTTATTTTTTGATCTT
TATTTGAGATTGTTTTCATATCTATCTAAATTATTAGGAGTGTGTGTATCAGAAGTAATTTTTTAATGTCTTCTAAGGATGGTCTTCCAG
GCTTTTAAACTGAAAAGCTTAATTCAGATAGTAGCTTTTGGCTGAGAAAAGGAATCCAAAATATTAATAAATTTAGATCTCAAAACCACT
ATTTTTATTATTTCATTATTTTTCAGAGGCCTTAAAATTCTGGATAAGAGAATGGAGGAAAATACTCAGAGTACTTGATTATTTTATTTC
CTTTTATTAAAAAATTACTTCTATGTTTTTATTGTCTCTTGAGCCTTAGTTAAGAGTAGTGTAGAAATGCATGAACTTCATCCTAATAAG
GATAAAACTTAAGGAAAACCACAATAAACCATGAAGGTGTACACATCTTATAACACAGATAAAGTTTTGGTGTGCTACCTATTCTTGAGA
GAGTGAGTGAGTGTATGTGTTTAAAGGAAACAAAATGGGAGAAATAAGTTTTAAAAAAATCCTCATTTTGTTAATATTCAAAAGATGGAC
TGAGCTTCCACTTGGGTTTTATCTTGTTTTAATTGTTTTTGTATCAAAACTTGAAATTCCTCTATTTCTATTGGGATATAAAAGCCTTCC
CCTTCAGTGAAGAAAACATTTATTTTTTATTTGATTCCTAGGATTTAGTAAACTCTAGCTGTCTATTTAAAATGTACTGAGGCACAACAA
GTATTATACTGGAAGACTTGCCAAACTGGCAAAGCTTTAAGTTCATCAGCATTCTATGTGGTTCAGAGCTGTGATTTTTGCAAAGTATTT
TACCAACCTCCTCGATGGCTTTGATAAAGGTTAGATTTGATGTTTTTTTTTAGATTTATTTTTCTTACTCCACTAAACTATAAAGAAAAT
AATTACTTAGAAACTCCATTTTAAATAATCATTTCCTAGAAATTCTTAAATATATACAGAATTTTAAAGAAAACATTTCATCTGATTTAG
TTAGCATCCACATATCATTGAGGAATTAAAGTGTGGGACAGTCATTATTAAAAAAAAGAGAGAAAAGCCCTCTATTAGACATTCCACAAT
CCATGTTTTAAGCTTATCCAAAGGTCCAAATGTCAGCCATTCTGTATGTTCATGTTGATCATTTGCGAACAAGAAAGCAGGTTTCTAGGT
ATCACTTAGGATGTGAACTGCCTCTCAACTTTAAACCCTGTTAGCTTTACTTTTTTAAGTCCACAAGTGATGAAACTAGTTTCTCAGCTA
GGCTTGTACTTTCCTCATTATTTCTAGTATTTCAAATATTCTCAAACAAAAGAGTTACCACTTTTCTCCATTTATTTTCAGTTATGGAAA
TGTTCCCTCTCTTCACCACTAAGCTCCAAAGCAAATGAAAGACGATCACATGTCAGGACAGTAGTAAAGGCAGCTTATAAATGGGACATA
AATCAGAGATGTGTTGGTATTTTGAGACTCAAGACTGTCCTTTTTTAAAATAAAAATAAAAACATTACCAGGTTCCCAAGCCAATCTGGC
TTAACCAACAGTGCACTGAAATATTAGTGTTTACCTCCAAGGCTAGGGAGCCAAGGGGAGGAGGAGAATTGGAGGAAGGGGAGATAATGG
GAAGAGGATGGCGCCTTCCTGAGTTGGCTAGAGGGCCAACCTTTGATAACAGTTTGACGAAATCAATCTTTTTTTTTTTTTTTTTTGAGA
CAGAGTCTCACTCTGTCACCCAGGCTGGAGTACAGTGGTGGGATCTCGGCTCACTGCAAGCTCTGCCTCCCAGGTTCATGCCATTCTCCT
GCCCCAGCCTCTCCTGAGTAGCTGGAACTACAGGTGCCCGCCACCACGCCCAGCTAATTTTTTCTATTTTTAGTCATGCCTGGCTAATTT
TTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCCATCTCCTTACCTCGCAATCCGCCCGCCTCAGCCTCCCA
AAGTGTTGGGATTACAGGCATGAGCCACCGTGCCCGGCCTATAGAAATCAATCTTTTTGACTCTTCTCACTTTTATCTCCCCATGCCCAA
GGTTTGCCTGTTCCATAACACTCACTCCCTTCCCCCTTGCTAATCAGAAGCCATCTCCTCTCAGTGTCTGATCTCTGCTCTTCATACATG
ATTACAGTCATGGGGTAGAGAGTGCTTGCTAAATTATGCAGTTAATCCTATGGTGCTTTAATTTTCAGGCCTTCAAAAAACACTTGTACA
GTGATGTGCAGATTTTTAAACAGTTGAACTTCCTTGTACTACAGTTTTTGTATTGACAGCCAAATTTGTCTTTCATTCTTCAGATTGTGA
ATAAAGTGATTTTTACAGGGCTTCCAGCAAAGTTTTTCCTTTCATCTAAGGCTTGTAGAACCCTAGCTTATATAGCTGCTTACATGAGAA
ATGCAAAATCTGTATTCACCATGACTTTAGTAACAAAGGTAAAGTTTTTTAGTAGTGCCAAGGCAAGAGGAACAATCTTGGTGGTAGTAC
TAAGTTTTGTCAATATTGTGGTTTCCTGATTGTATTGTTGGCTTTCTCTCTGAGCATTGAGGTATACTAGAAGTAGAGCTTCTCAAACAT
AATATCATTACCTCATAAGCATTAACAAATCAGGCCCAAAGAGCGTAAGTCCTAGAAATTTGTTTTAAAGCAGCCCTAGTCATGGTGCTG
GTGCTACCGCCTTGTTTTAGGAGCCTGCCTCCTGTCAGTATGAAACCCTCACCTGAAAAATGCCAGCCTGGACACCAAACACTGAGCCCC
TTCAACAGGCACATTATTTCCCCCTGAGATCCATAAGGGAATTTAGTTTCTACTATTGTAGAGTTCTGAAAAGAGGTAAAATAGTAGTCC
TTTGGTCATCCTATTTTTGCTTTCAATTTTGATATTTCAGACTGTAAAAGGCCTTGGGGGATGATAGTACATGTGGTAGCAGTAATTTTT
TTGAAGCAACTGCACTGACATTCATTTGAGTTTTCTCTCATTATCAGATTCTGTTCCAAACAAGTATTCTGTAGATCCAAATGGATTACC
AGTGTGCTACAGACTTCTTATTATAGAACAGCATTCTATTCTACATCAAAAATAGTTTGTGTAAGTTAGTTTTGGTTACCATCTAAAATA
TTTTTAAATGTTCTTTACATAAAAATTTATGTTGTGTTTTAAAATCCTTAGGGGCTTTATCTATTTTTCTAAGTCAGTTAACTGTACTTC
TAAAAAAAGTATTTTGTATCTACTTTTGTAACTTCGTCAGAATAAAATATATTGAAAGCAAGAAATGACTGATTAAAGTATGTATATCAA

>85761_85761_1_SPG7-MOB1A_SPG7_chr16_89579445_ENST00000268704_MOB1A_chr2_74394234_ENST00000396049_length(amino acids)=281AA_BP=125
MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVR
LWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEAVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYI
DYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQ

--------------------------------------------------------------
>85761_85761_2_SPG7-MOB1A_SPG7_chr16_89579445_ENST00000341316_MOB1A_chr2_74394234_ENST00000396049_length(transcript)=4893nt_BP=383nt
GGCCAACATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCAGGCCCGGC
CTGGAGTCCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCTGGAGGCCG
AGCTCTGCAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTTCAGAATCC
AGTCAGACTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAGTCGAAGGG
GAAGGCGCCTGAAGAGGACGAAGCTGTGGATTTCTTTAACCAGATCAACATGTTATATGGAACTATTACAGAATTCTGCACTGAAGCAAG
CTGTCCAGTCATGTCTGCAGGTCCGAGATATGAATATCACTGGGCAGATGGTACTAATATTAAAAAGCCAATCAAATGTTCTGCACCAAA
ATACATTGACTATTTGATGACTTGGGTTCAAGATCAGCTTGATGATGAAACTCTTTTTCCTTCTAAGATTGGTGTCCCATTTCCCAAAAA
CTTTATGTCTGTGGCAAAGACTATTCTAAAGCGTCTGTTCAGGGTTTATGCCCATATTTATCACCAGCACTTTGATTCTGTGATGCAGCT
GCAAGAGGAGGCCCACCTCAACACCTCCTTTAAGCACTTTATTTTCTTTGTTCAGGAGTTTAATCTGATTGATAGGCGTGAGCTGGCACC
TCTTCAAGAATTAATAGAGAAACTTGGATCAAAAGACAGATAAATGTTTCTTCTAGAACACAGTTACCCCCTTGCTTCATCTATTGCTAG
AACTATCTCATTGCTATCTGTTATAGACTAGTGATACAAACTTTAAGAAAACAGGATAAAAAGATACCCATTGCCTGTGTCTACTGATAA
AATTATCCCAAAGGTAGGTTGGTGTGATAGTTTCCGAGTAAGACCTTAAGGACACAGCCAAATCTTAAGTACTGTGTGACCACTCTTGTT
GTTATCACATAGTCATACTTGGTTGTAATATGTGATGGTTAACCTGTAGCTTATAAATTTACTTATTATTCTTTTACTCATTTACTCAGT
CATTTCTTTACAAGAAAATGATTGAATCTGTTTTAGGTGACAGCACAATGGACATTAAGAATTTCCATCAATAATTTATGAATAAGTTTC
CAGAACAAATTTCCTAATAACACAATCAGATTGGTTTTATTCTTTTATTTTACGAATAAAAAATGTATTTTTCAGTATCCTTGAGATTTA
GAACATCTGTGTCACTTCAGATAACATTTTAGTTTCAAGTTTGTATGGTAGTGTTTTTATAGATAAGATACGTCTATTTTTTCAAAATTC
ATGATTGCAGTTTAAATCATCATATGACGTGTGGGTGGGAGCAACCAAAGTTATTTTTACAGGGACTTTATTTTTTGATCTTTATTTGAG
ATTGTTTTCATATCTATCTAAATTATTAGGAGTGTGTGTATCAGAAGTAATTTTTTAATGTCTTCTAAGGATGGTCTTCCAGGCTTTTAA
ACTGAAAAGCTTAATTCAGATAGTAGCTTTTGGCTGAGAAAAGGAATCCAAAATATTAATAAATTTAGATCTCAAAACCACTATTTTTAT
TATTTCATTATTTTTCAGAGGCCTTAAAATTCTGGATAAGAGAATGGAGGAAAATACTCAGAGTACTTGATTATTTTATTTCCTTTTATT
AAAAAATTACTTCTATGTTTTTATTGTCTCTTGAGCCTTAGTTAAGAGTAGTGTAGAAATGCATGAACTTCATCCTAATAAGGATAAAAC
TTAAGGAAAACCACAATAAACCATGAAGGTGTACACATCTTATAACACAGATAAAGTTTTGGTGTGCTACCTATTCTTGAGAGAGTGAGT
GAGTGTATGTGTTTAAAGGAAACAAAATGGGAGAAATAAGTTTTAAAAAAATCCTCATTTTGTTAATATTCAAAAGATGGACTGAGCTTC
CACTTGGGTTTTATCTTGTTTTAATTGTTTTTGTATCAAAACTTGAAATTCCTCTATTTCTATTGGGATATAAAAGCCTTCCCCTTCAGT
GAAGAAAACATTTATTTTTTATTTGATTCCTAGGATTTAGTAAACTCTAGCTGTCTATTTAAAATGTACTGAGGCACAACAAGTATTATA
CTGGAAGACTTGCCAAACTGGCAAAGCTTTAAGTTCATCAGCATTCTATGTGGTTCAGAGCTGTGATTTTTGCAAAGTATTTTACCAACC
TCCTCGATGGCTTTGATAAAGGTTAGATTTGATGTTTTTTTTTAGATTTATTTTTCTTACTCCACTAAACTATAAAGAAAATAATTACTT
AGAAACTCCATTTTAAATAATCATTTCCTAGAAATTCTTAAATATATACAGAATTTTAAAGAAAACATTTCATCTGATTTAGTTAGCATC
CACATATCATTGAGGAATTAAAGTGTGGGACAGTCATTATTAAAAAAAAGAGAGAAAAGCCCTCTATTAGACATTCCACAATCCATGTTT
TAAGCTTATCCAAAGGTCCAAATGTCAGCCATTCTGTATGTTCATGTTGATCATTTGCGAACAAGAAAGCAGGTTTCTAGGTATCACTTA
GGATGTGAACTGCCTCTCAACTTTAAACCCTGTTAGCTTTACTTTTTTAAGTCCACAAGTGATGAAACTAGTTTCTCAGCTAGGCTTGTA
CTTTCCTCATTATTTCTAGTATTTCAAATATTCTCAAACAAAAGAGTTACCACTTTTCTCCATTTATTTTCAGTTATGGAAATGTTCCCT
CTCTTCACCACTAAGCTCCAAAGCAAATGAAAGACGATCACATGTCAGGACAGTAGTAAAGGCAGCTTATAAATGGGACATAAATCAGAG
ATGTGTTGGTATTTTGAGACTCAAGACTGTCCTTTTTTAAAATAAAAATAAAAACATTACCAGGTTCCCAAGCCAATCTGGCTTAACCAA
CAGTGCACTGAAATATTAGTGTTTACCTCCAAGGCTAGGGAGCCAAGGGGAGGAGGAGAATTGGAGGAAGGGGAGATAATGGGAAGAGGA
TGGCGCCTTCCTGAGTTGGCTAGAGGGCCAACCTTTGATAACAGTTTGACGAAATCAATCTTTTTTTTTTTTTTTTTTGAGACAGAGTCT
CACTCTGTCACCCAGGCTGGAGTACAGTGGTGGGATCTCGGCTCACTGCAAGCTCTGCCTCCCAGGTTCATGCCATTCTCCTGCCCCAGC
CTCTCCTGAGTAGCTGGAACTACAGGTGCCCGCCACCACGCCCAGCTAATTTTTTCTATTTTTAGTCATGCCTGGCTAATTTTTTGTATT
TTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCCATCTCCTTACCTCGCAATCCGCCCGCCTCAGCCTCCCAAAGTGTTG
GGATTACAGGCATGAGCCACCGTGCCCGGCCTATAGAAATCAATCTTTTTGACTCTTCTCACTTTTATCTCCCCATGCCCAAGGTTTGCC
TGTTCCATAACACTCACTCCCTTCCCCCTTGCTAATCAGAAGCCATCTCCTCTCAGTGTCTGATCTCTGCTCTTCATACATGATTACAGT
CATGGGGTAGAGAGTGCTTGCTAAATTATGCAGTTAATCCTATGGTGCTTTAATTTTCAGGCCTTCAAAAAACACTTGTACAGTGATGTG
CAGATTTTTAAACAGTTGAACTTCCTTGTACTACAGTTTTTGTATTGACAGCCAAATTTGTCTTTCATTCTTCAGATTGTGAATAAAGTG
ATTTTTACAGGGCTTCCAGCAAAGTTTTTCCTTTCATCTAAGGCTTGTAGAACCCTAGCTTATATAGCTGCTTACATGAGAAATGCAAAA
TCTGTATTCACCATGACTTTAGTAACAAAGGTAAAGTTTTTTAGTAGTGCCAAGGCAAGAGGAACAATCTTGGTGGTAGTACTAAGTTTT
GTCAATATTGTGGTTTCCTGATTGTATTGTTGGCTTTCTCTCTGAGCATTGAGGTATACTAGAAGTAGAGCTTCTCAAACATAATATCAT
TACCTCATAAGCATTAACAAATCAGGCCCAAAGAGCGTAAGTCCTAGAAATTTGTTTTAAAGCAGCCCTAGTCATGGTGCTGGTGCTACC
GCCTTGTTTTAGGAGCCTGCCTCCTGTCAGTATGAAACCCTCACCTGAAAAATGCCAGCCTGGACACCAAACACTGAGCCCCTTCAACAG
GCACATTATTTCCCCCTGAGATCCATAAGGGAATTTAGTTTCTACTATTGTAGAGTTCTGAAAAGAGGTAAAATAGTAGTCCTTTGGTCA
TCCTATTTTTGCTTTCAATTTTGATATTTCAGACTGTAAAAGGCCTTGGGGGATGATAGTACATGTGGTAGCAGTAATTTTTTTGAAGCA
ACTGCACTGACATTCATTTGAGTTTTCTCTCATTATCAGATTCTGTTCCAAACAAGTATTCTGTAGATCCAAATGGATTACCAGTGTGCT
ACAGACTTCTTATTATAGAACAGCATTCTATTCTACATCAAAAATAGTTTGTGTAAGTTAGTTTTGGTTACCATCTAAAATATTTTTAAA
TGTTCTTTACATAAAAATTTATGTTGTGTTTTAAAATCCTTAGGGGCTTTATCTATTTTTCTAAGTCAGTTAACTGTACTTCTAAAAAAA
GTATTTTGTATCTACTTTTGTAACTTCGTCAGAATAAAATATATTGAAAGCAAGAAATGACTGATTAAAGTATGTATATCAACACACATT

>85761_85761_2_SPG7-MOB1A_SPG7_chr16_89579445_ENST00000341316_MOB1A_chr2_74394234_ENST00000396049_length(amino acids)=281AA_BP=125
MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVR
LWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEAVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYI
DYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQ

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Fusion Gene PPI Analysis for SPG7-MOB1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPG7chr16:89579445chr2:74394234ENST00000268704+317701_795125.33333333333333796.0PPIF
HgeneSPG7chr16:89579445chr2:74394234ENST00000341316+310701_795125.33333333333333490.0PPIF


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPG7-MOB1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPG7-MOB1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource