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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPIDR-DSCAM (FusionGDB2 ID:85787)

Fusion Gene Summary for SPIDR-DSCAM

check button Fusion gene summary
Fusion gene informationFusion gene name: SPIDR-DSCAM
Fusion gene ID: 85787
HgeneTgene
Gene symbol

SPIDR

DSCAM

Gene ID

23514

1826

Gene namescaffold protein involved in DNA repairDS cell adhesion molecule
SynonymsKIAA0146CHD2|CHD2-42|CHD2-52
Cytomap

8q11.21

21q22.2

Type of geneprotein-codingprotein-coding
DescriptionDNA repair-scaffolding proteinscaffolding protein involved in DNA repairDown syndrome cell adhesion molecule
Modification date2020032020200313
UniProtAcc

Q14159

Q8TD84

Ensembl transtripts involved in fusion geneENST00000521214, ENST00000297423, 
ENST00000518074, ENST00000541342, 
ENST00000517693, ENST00000518060, 
ENST00000400454, 
Fusion gene scores* DoF score24 X 12 X 15=432013 X 11 X 6=858
# samples 2715
** MAII scorelog2(27/4320*10)=-4
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/858*10)=-2.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPIDR [Title/Abstract] AND DSCAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPIDR(48206619)-DSCAM(41559914), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPIDR

GO:0006974

cellular response to DNA damage stimulus

23509288

HgeneSPIDR

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

HgeneSPIDR

GO:0031334

positive regulation of protein complex assembly

23509288

HgeneSPIDR

GO:0070202

regulation of establishment of protein localization to chromosome

23509288

HgeneSPIDR

GO:0071479

cellular response to ionizing radiation

23509288|23754376

HgeneSPIDR

GO:0072711

cellular response to hydroxyurea

23509288

HgeneSPIDR

GO:0072757

cellular response to camptothecin

23509288

TgeneDSCAM

GO:0042327

positive regulation of phosphorylation

19196994

TgeneDSCAM

GO:0048842

positive regulation of axon extension involved in axon guidance

18585357


check buttonFusion gene breakpoints across SPIDR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DSCAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-36-1577-01ASPIDRchr8

48206619

+DSCAMchr21

41559914

-


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Fusion Gene ORF analysis for SPIDR-DSCAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000521214ENST00000400454SPIDRchr8

48206619

+DSCAMchr21

41559914

-
In-frameENST00000297423ENST00000400454SPIDRchr8

48206619

+DSCAMchr21

41559914

-
In-frameENST00000518074ENST00000400454SPIDRchr8

48206619

+DSCAMchr21

41559914

-
In-frameENST00000541342ENST00000400454SPIDRchr8

48206619

+DSCAMchr21

41559914

-
intron-3CDSENST00000517693ENST00000400454SPIDRchr8

48206619

+DSCAMchr21

41559914

-
intron-3CDSENST00000518060ENST00000400454SPIDRchr8

48206619

+DSCAMchr21

41559914

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297423SPIDRchr848206619+ENST00000400454DSCAMchr2141559914-64309095143941447
ENST00000518074SPIDRchr848206619+ENST00000400454DSCAMchr2141559914-603751617140011276
ENST00000541342SPIDRchr848206619+ENST00000400454DSCAMchr2141559914-598246114639461266

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297423ENST00000400454SPIDRchr848206619+DSCAMchr2141559914-0.0016151270.99838483
ENST00000518074ENST00000400454SPIDRchr848206619+DSCAMchr2141559914-0.0011189110.99888104
ENST00000541342ENST00000400454SPIDRchr848206619+DSCAMchr2141559914-0.0010387140.9989613

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Fusion Genomic Features for SPIDR-DSCAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPIDR-DSCAM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:48206619/chr21:41559914)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPIDR

Q14159

DSCAM

Q8TD84

FUNCTION: Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. {ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}.FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:E1C8P7, ECO:0000250|UniProtKB:Q4VA61, ECO:0000269|PubMed:11453658}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDSCAMchr8:48206619chr21:41559914ENST0000040045411331091_11878512013.0DomainFibronectin type-III 3
TgeneDSCAMchr8:48206619chr21:41559914ENST0000040045411331191_12858512013.0DomainFibronectin type-III 4
TgeneDSCAMchr8:48206619chr21:41559914ENST0000040045411331285_13778512013.0DomainNote=Ig-like C2-type 10
TgeneDSCAMchr8:48206619chr21:41559914ENST0000040045411331379_14738512013.0DomainFibronectin type-III 5
TgeneDSCAMchr8:48206619chr21:41559914ENST0000040045411331474_15758512013.0DomainFibronectin type-III 6
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133885_9828512013.0DomainFibronectin type-III 1
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133987_10868512013.0DomainFibronectin type-III 2
TgeneDSCAMchr8:48206619chr21:41559914ENST0000040045411331617_20128512013.0RegionRequired for netrin-mediated axon repulsion of neuronal growth cones
TgeneDSCAMchr8:48206619chr21:41559914ENST0000040045411331596_16168512013.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133125_2168512013.0DomainNote=Ig-like C2-type 2
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133225_3058512013.0DomainNote=Ig-like C2-type 3
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133313_4018512013.0DomainNote=Ig-like C2-type 4
TgeneDSCAMchr8:48206619chr21:41559914ENST00000400454113339_1298512013.0DomainNote=Ig-like C2-type 1
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133407_5008512013.0DomainNote=Ig-like C2-type 5
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133504_5928512013.0DomainNote=Ig-like C2-type 6
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133596_6858512013.0DomainNote=Ig-like C2-type 7
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133690_7838512013.0DomainNote=Ig-like C2-type 8
TgeneDSCAMchr8:48206619chr21:41559914ENST000004004541133787_8838512013.0DomainNote=Ig-like C2-type 9
TgeneDSCAMchr8:48206619chr21:41559914ENST00000400454113318_15958512013.0Topological domainExtracellular


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Fusion Gene Sequence for SPIDR-DSCAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85787_85787_1_SPIDR-DSCAM_SPIDR_chr8_48206619_ENST00000297423_DSCAM_chr21_41559914_ENST00000400454_length(transcript)=6430nt_BP=909nt
AGTTGTTGCCTGACAACACAGACGACAGTAACTTAATTCGAAAGACAATACTTGGAGGCGGCCCCCGCTCCAGGCACCAGCCCAGCAGCT
CCCCCGAACTCCCCAGGAGCTCGCGGGCGAGCAACGCCACAGCCCAGAGCGAGCTCCGCGGAACCCCCAGCCCCGGGGAAGGAAGCTCGA
CTCTCCGCGGGGCACTCCTTCCGGGCTCCGGGCCCGACTAGGCCATCCGGGAGGCCCTGGAGCGCCGGGGCCGGAGAAGCCCTGCCCCCC
GCCGAAGCCCCGCCCTGCGCCCGAGCGCCCGCCAATGGCAGGGCGCGGTGCGGCGCGCCGAGGTGGGACGGCGGCGCGCTGAGGAGGCGG
TGCGCTCAGGCGGCGCTCCCGGAGATGCCCCGCGGCAGCCGCGCTCGGGGCTCTAAGAGAAAAAGGAGTTGGAATACAGAATGCCCATCC
TTTCCAGGAGAAAGACCACTGCAGGTCAGAAGAGCAGGTCTCAGGACAGCAGGGGCAGCTGCCTCTCTCTCTGAAGCATGGCTCAGGTGT
GGAGAAGGGTTTCAGAACACTTCTGGGAATCCGTCATTAACAGCTGAAGAGAAGACGATTACAGAAAAGCACCTTGAATTATGCCCTAGA
CCCAAGCAAGAAACCACCACATCTAAAAGCACCAGTGGGCTTACAGACATAACATGGAGCTCCAGTGGAAGTGATTTGTCGGATGAAGAT
AAGACACTTTCTCAGTTACAGAGAGATGAATTACAGTTTATCGACTGGGAGATTGACAGTGACAGGGCAGAGGCTAGTGACTGTGATGAA
TTTGAAGATGACGAGGGTGCTGTGGAAATCTCAGACTGTGCTTCTTGTGCAAGTAATCAGTCTTTGACAAGTGATGAGAAGCTGTCGGAG
CTTCCCAAGATTTTGCCAACTGTGAGAGAAGATTCTGGTTTCTTTTCCTGCCATGCTATTAATTCTTATGGGGAGGACCGTGGAATAATT
CAGCTCACAGTGCAAGAGCCCCCAGACCCTCCCGAAATTGAGATCAAAGATGTCAAAGCACGCACAATTACGCTCAGGTGGACCATGGGG
TTTGATGGAAACAGTCCCATCACAGGCTACGATATTGAATGCAAAAATAAATCAGACTCCTGGGATTCTGCTCAGAGAACCAAAGATGTT
TCCCCTCAGCTGAACTCGGCCACCATCATTGATATCCACCCTTCCTCCACCTACAGCATCCGCATGTACGCCAAGAACCGGATTGGCAAG
AGCGAGCCCAGCAACGAGCTCACCATCACGGCGGACGAGGCAGCTCCTGATGGTCCACCTCAGGAAGTTCACCTGGAGCCTATATCATCT
CAGAGCATCAGGGTCACATGGAAGGCTCCCAAGAAACATTTGCAAAATGGGATTATCCGTGGCTACCAAATAGGTTACCGAGAGTACAGC
ACTGGGGGTAACTTCCAATTCAACATTATCAGTGTCGACACCAGCGGGGACAGTGAGGTTTACACCCTGGACAACCTGAATAAGTTCACT
CAGTACGGCCTGGTGGTGCAGGCCTGTAACCGGGCCGGCACGGGGCCTTCTTCTCAGGAAATCATCACCACCACTCTCGAGGATGTGCCC
AGTTACCCCCCCGAAAATGTCCAAGCCATAGCAACATCACCAGAAAGCATATCAATATCCTGGTCCACACTTTCCAAGGAAGCCTTGAAT
GGAATTCTCCAGGGGTTCAGAGTCATTTACTGGGCCAACCTCATGGACGGAGAGCTGGGTGAGATTAAAAACATCACCACCACACAGCCT
TCACTGGAGCTGGACGGGCTGGAAAAGTACACCAACTACAGCATCCAGGTGCTGGCCTTCACCCGCGCAGGAGACGGGGTCAGGAGTGAG
CAGATCTTCACCCGGACCAAAGAGGATGTTCCAGGTCCTCCCGCGGGTGTGAAGGCAGCGGCGGCCTCAGCCTCCATGGTCTTTGTGTCC
TGGCTTCCCCCTCTCAAGCTGAACGGCATCATCCGAAAGTACACTGTATTCTGCTCCCACCCCTATCCCACAGTGATCAGCGAGTTTGAG
GCCTCTCCCGACTCGTTTTCCTACAGAATTCCCAACCTGAGTAGGAATCGTCAGTACAGCGTCTGGGTGGTGGCTGTTACTTCAGCCGGA
AGAGGCAACAGCAGTGAAATCATCACAGTCGAGCCACTAGCAAAAGCTCCTGCACGAATCCTGACCTTCAGTGGGACAGTGACTACTCCA
TGGATGAAAGACATTGTCTTGCCTTGTAAGGCTGTTGGGGACCCTTCTCCTGCAGTCAAATGGATGAAAGACAGTAACGGGACACCCAGT
CTAGTAACGATTGATGGGCGGAGGAGCATCTTTAGCAACGGAAGCTTCATTATTCGCACGGTGAAAGCAGAAGACTCCGGCTATTACAGC
TGCATTGCCAATAACAACTGGGGATCTGATGAAATTATTTTAAACTTACAAGTACAAGTTCCACCAGATCAGCCTCGGCTTACAGTCTCC
AAGACCACGTCTTCCTCCATCACCCTTTCTTGGCTCCCTGGAGACAACGGGGGCAGCTCTATCAGAGGATACATACTGCAGTACTCCGAG
GACAATAGTGAGCAGTGGGGGAGTTTTCCAATCAGCCCCAGCGAACGTTCCTATCGCTTGGAAAATCTCAAATGTGGGACTTGGTATAAG
TTCACACTGACAGCCCAAAATGGAGTGGGCCCAGGGCGCATAAGTGAAATCATAGAAGCAAAGACCTTAGGAAAAGAGCCCCAGTTCTCA
AAGGAGCAGGAGCTGTTTGCCAGCATCAACACCACACGCGTGAGGCTGAACCTCATTGGCTGGAATGATGGCGGCTGCCCCATCACCTCC
TTCACACTAGAGTACAGGCCCTTTGGGACCACAGTTTGGACCACAGCTCAGAGGACCTCTCTCTCCAAGTCCTACATCCTGTATGACCTG
CAGGAAGCCACCTGGTATGAGCTGCAGATGCGGGTGTGCAACAGTGCGGGCTGCGCGGAGAAGCAGGCCAACTTCGCTACGCTGAACTAC
GATGGCAGTACAATTCCTCCACTCATTAAGTCAGTTGTCCAAAACGAAGAAGGGCTGACGACCAACGAGGGGCTCAAGATGCTGGTGACC
ATCTCCTGTATCCTGGTGGGGGTCTTGCTGCTGTTTGTGCTCCTGCTGGTTGTGCGGAGGAGGCGGCGGGAGCAGAGGCTAAAGAGGCTG
CGAGATGCAAAGAGTTTAGCTGAAATGCTCATGAGTAAGAATACCCGGACTTCAGATACGTTAAGCAAGCAACAGCAGACCCTGCGAATG
CACATCGACATACCCAGGGCTCAGCTTTTGATTGAAGAGAGAGACACGATGGAGACCATTGATGATCGCTCCACGGTTCTGTTGACGGAT
GCTGACTTTGGAGAGGCAGCTAAGCAGAAGTCCCTGACGGTCACTCACACGGTCCATTACCAATCGGTGTCTCAGGCCACTGGGCCCTTA
GTGGATGTTTCAGACGCTCGGCCGGGAACGAATCCCACCACCAGGAGGAATGCCAAGGCTGGGCCCACAGCGAGAAACCGCTATGCCAGC
CAGTGGACCCTCAACCGACCCCACCCCACCATCTCAGCACACACCCTCACCACAGACTGGAGGCTGCCAACACCCAGGGCTGCAGGATCA
GTAGACAAAGAGAGCGACAGTTACAGCGTCAGCCCCTCGCAAGACACAGATCGAGCAAGAAGCAGCATGGTCTCCACAGAAAGTGCCTCC
TCCACTTACGAAGAACTGGCCAGGGCCTACGAACACGCCAAGATGGAAGAGCAACTGAGGCACGCCAAGTTCACCATCACGGAGTGCTTC
ATATCAGACACGTCATCGGAGCAGTTGACGGCAGGGACAAATGAGTACACGGACAGTCTGACCTCCAGCACCCCTTCCGAATCGGGAATC
TGCAGGTTCACTGCATCTCCCCCCAAACCTCAGGATGGAGGAAGAGTAATGAATATGGCAGTTCCAAAGGCACATCGGCCAGGTGACCTC
ATACATTTGCCTCCATACCTTAGAATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGAGCTTAGGACAAGCATGC
TTGGAACCTCAGAAAAGCCGGACCCTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCTCCGCCTCCTCCACGAGA
GAAGGACAGTCGTGGCAGCCGGGGGCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAGCTAAAATGAGCAGCTCC
CAAGAATCACTGCTCGACTCCCGGGGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTATAACAGACAGCATGACTG
GACAGCGGTTGTAAATACAATTCAAACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATAATTAAAGAAAATTGCCA
AAATATATTAAAAAAAAAAAAGAGAAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTGTCTGAGTGTGAGCTCCA
TCCGCCTGGGCATCTGATTTTTTGGGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTGATTTTCTACAAAAGTGC
ATGGGGGGGATTAATTAAACCTTCTGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGTGGGAAATCAGCCTATTT
GTGAATTTAAAAGGAACACCGATTTGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCATTAGAAACCGGGTTCTCA
ATTTGGTCTTCTTTTGTTGTTAATTAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTCTCTCTTGTTTCTTTTTT
AATTTAATGAGACACTCTTTGCATTTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCATGTCTGCTTCTCTCGTCT
TCTGCCAGTGGCCTGGTCCTCCTTCCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAATTCAATAAACCAGAGTC
GATACTAACACCCTGAACTCCTCAGGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGGAGAGGACAAAATGCAGG
CTGGTCTCCACCGCAACCAGAGGCCAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCCATGGCCAGAGTTCAACT
GACTGTGGCCTATGGGCCAAATCCAGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATGCACTATTTGCTATTGTC
TATGGCTGCTTTCATGGCACAATGGTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAAATATTTATTACCTGGCC
CATTACAGGAAACATTTGCCAGACCCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCAAGATCGTGCATCTTACC
CTCCATGACTTTTCCTATCTCCACTATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCTGAATCCTCTGTAACCAG
AGGAAAGTGATGTTCCTCTAAAATCTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATCCTAAGAGAGAATTTACT
CATAAATAGTCGGAACTGCATTCTTTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCCTCCCCTGGCTGCAACAC
TCCATTCCAGGCTCACTTCCATAAAATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGAAAACATGATCAAATATC
CACAGCTGCTCAGTCTCCCAGGCTGAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCCAGTTATTACCATCTTGG
GAACATATTCAGAAATGTCTTTCCTTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTTTCCAGGCAGGCCCATTT
GTCTGCTTAGATTCAGTGACACAGAATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGATGACTCCAGGAATGTGAG
GTGTGCATCCATGGTTTCAGAATGTAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTTTTATGCAAAAGAAATGT
TACTTTCTGGGGGAAAAAATTAAAAGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAGTTTACCTTTTTAACATT

>85787_85787_1_SPIDR-DSCAM_SPIDR_chr8_48206619_ENST00000297423_DSCAM_chr21_41559914_ENST00000400454_length(amino acids)=1447AA_BP=280
MEAAPAPGTSPAAPPNSPGARGRATPQPRASSAEPPAPGKEARLSAGHSFRAPGPTRPSGRPWSAGAGEALPPAEAPPCARAPANGRARC
GAPRWDGGALRRRCAQAALPEMPRGSRARGSKRKRSWNTECPSFPGERPLQVRRAGLRTAGAAASLSEAWLRCGEGFQNTSGNPSLTAEE
KTITEKHLELCPRPKQETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQRDELQFIDWEIDSDRAEASDCDEFEDDEGAVEISDCASCA
SNQSLTSDEKLSELPKILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNK
SDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNG
IIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI
SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGV
KAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAP
ARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQ
VQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI
IEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG
CAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRT
SDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRN
AKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEE
QLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGG
PGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPY

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>85787_85787_2_SPIDR-DSCAM_SPIDR_chr8_48206619_ENST00000518074_DSCAM_chr21_41559914_ENST00000400454_length(transcript)=6037nt_BP=516nt
GCGGTGCGCTCAGGCGGCGCTCCCGGAGATGCCCCGCGGCAGCCGCGCTCGGGGCTCTAAGAGAAAAAGGAGTTGGAATACAGAATGCCC
ATCCTTTCCAGGAGAAAGACCACTGCAGGTCAGAAGAGCAGGTCTCAGGACAGCAGGGGCAGCTGCCTCTCTCTCTGAAGCATGGCTCAG
TCATTAACAGCTGAAGAGAAGACGATTACAGAAAAGCACCTTGAATTATGCCCTAGACCCAAGCAAGAAACCACCACATCTAAAAGCACC
AGTGGGCTTACAGACATAACATGGAGCTCCAGTGGAAGTGATTTGTCGGATGAAGATAAGACACTTTCTCAGTTACAGAGAGATGAATTA
CAGTTTATCGACTGGGAGATTGACAGTGACAGGGCAGAGGCTAGTGACTGTGATGAATTTGAAGATGACGAGGGTGCTGTGGAAATCTCA
GACTGTGCTTCTTGTGCAAGTAATCAGTCTTTGACAAGTGATGAGAAGCTGTCGGAGCTTCCCAAGATTTTGCCAACTGTGAGAGAAGAT
TCTGGTTTCTTTTCCTGCCATGCTATTAATTCTTATGGGGAGGACCGTGGAATAATTCAGCTCACAGTGCAAGAGCCCCCAGACCCTCCC
GAAATTGAGATCAAAGATGTCAAAGCACGCACAATTACGCTCAGGTGGACCATGGGGTTTGATGGAAACAGTCCCATCACAGGCTACGAT
ATTGAATGCAAAAATAAATCAGACTCCTGGGATTCTGCTCAGAGAACCAAAGATGTTTCCCCTCAGCTGAACTCGGCCACCATCATTGAT
ATCCACCCTTCCTCCACCTACAGCATCCGCATGTACGCCAAGAACCGGATTGGCAAGAGCGAGCCCAGCAACGAGCTCACCATCACGGCG
GACGAGGCAGCTCCTGATGGTCCACCTCAGGAAGTTCACCTGGAGCCTATATCATCTCAGAGCATCAGGGTCACATGGAAGGCTCCCAAG
AAACATTTGCAAAATGGGATTATCCGTGGCTACCAAATAGGTTACCGAGAGTACAGCACTGGGGGTAACTTCCAATTCAACATTATCAGT
GTCGACACCAGCGGGGACAGTGAGGTTTACACCCTGGACAACCTGAATAAGTTCACTCAGTACGGCCTGGTGGTGCAGGCCTGTAACCGG
GCCGGCACGGGGCCTTCTTCTCAGGAAATCATCACCACCACTCTCGAGGATGTGCCCAGTTACCCCCCCGAAAATGTCCAAGCCATAGCA
ACATCACCAGAAAGCATATCAATATCCTGGTCCACACTTTCCAAGGAAGCCTTGAATGGAATTCTCCAGGGGTTCAGAGTCATTTACTGG
GCCAACCTCATGGACGGAGAGCTGGGTGAGATTAAAAACATCACCACCACACAGCCTTCACTGGAGCTGGACGGGCTGGAAAAGTACACC
AACTACAGCATCCAGGTGCTGGCCTTCACCCGCGCAGGAGACGGGGTCAGGAGTGAGCAGATCTTCACCCGGACCAAAGAGGATGTTCCA
GGTCCTCCCGCGGGTGTGAAGGCAGCGGCGGCCTCAGCCTCCATGGTCTTTGTGTCCTGGCTTCCCCCTCTCAAGCTGAACGGCATCATC
CGAAAGTACACTGTATTCTGCTCCCACCCCTATCCCACAGTGATCAGCGAGTTTGAGGCCTCTCCCGACTCGTTTTCCTACAGAATTCCC
AACCTGAGTAGGAATCGTCAGTACAGCGTCTGGGTGGTGGCTGTTACTTCAGCCGGAAGAGGCAACAGCAGTGAAATCATCACAGTCGAG
CCACTAGCAAAAGCTCCTGCACGAATCCTGACCTTCAGTGGGACAGTGACTACTCCATGGATGAAAGACATTGTCTTGCCTTGTAAGGCT
GTTGGGGACCCTTCTCCTGCAGTCAAATGGATGAAAGACAGTAACGGGACACCCAGTCTAGTAACGATTGATGGGCGGAGGAGCATCTTT
AGCAACGGAAGCTTCATTATTCGCACGGTGAAAGCAGAAGACTCCGGCTATTACAGCTGCATTGCCAATAACAACTGGGGATCTGATGAA
ATTATTTTAAACTTACAAGTACAAGTTCCACCAGATCAGCCTCGGCTTACAGTCTCCAAGACCACGTCTTCCTCCATCACCCTTTCTTGG
CTCCCTGGAGACAACGGGGGCAGCTCTATCAGAGGATACATACTGCAGTACTCCGAGGACAATAGTGAGCAGTGGGGGAGTTTTCCAATC
AGCCCCAGCGAACGTTCCTATCGCTTGGAAAATCTCAAATGTGGGACTTGGTATAAGTTCACACTGACAGCCCAAAATGGAGTGGGCCCA
GGGCGCATAAGTGAAATCATAGAAGCAAAGACCTTAGGAAAAGAGCCCCAGTTCTCAAAGGAGCAGGAGCTGTTTGCCAGCATCAACACC
ACACGCGTGAGGCTGAACCTCATTGGCTGGAATGATGGCGGCTGCCCCATCACCTCCTTCACACTAGAGTACAGGCCCTTTGGGACCACA
GTTTGGACCACAGCTCAGAGGACCTCTCTCTCCAAGTCCTACATCCTGTATGACCTGCAGGAAGCCACCTGGTATGAGCTGCAGATGCGG
GTGTGCAACAGTGCGGGCTGCGCGGAGAAGCAGGCCAACTTCGCTACGCTGAACTACGATGGCAGTACAATTCCTCCACTCATTAAGTCA
GTTGTCCAAAACGAAGAAGGGCTGACGACCAACGAGGGGCTCAAGATGCTGGTGACCATCTCCTGTATCCTGGTGGGGGTCTTGCTGCTG
TTTGTGCTCCTGCTGGTTGTGCGGAGGAGGCGGCGGGAGCAGAGGCTAAAGAGGCTGCGAGATGCAAAGAGTTTAGCTGAAATGCTCATG
AGTAAGAATACCCGGACTTCAGATACGTTAAGCAAGCAACAGCAGACCCTGCGAATGCACATCGACATACCCAGGGCTCAGCTTTTGATT
GAAGAGAGAGACACGATGGAGACCATTGATGATCGCTCCACGGTTCTGTTGACGGATGCTGACTTTGGAGAGGCAGCTAAGCAGAAGTCC
CTGACGGTCACTCACACGGTCCATTACCAATCGGTGTCTCAGGCCACTGGGCCCTTAGTGGATGTTTCAGACGCTCGGCCGGGAACGAAT
CCCACCACCAGGAGGAATGCCAAGGCTGGGCCCACAGCGAGAAACCGCTATGCCAGCCAGTGGACCCTCAACCGACCCCACCCCACCATC
TCAGCACACACCCTCACCACAGACTGGAGGCTGCCAACACCCAGGGCTGCAGGATCAGTAGACAAAGAGAGCGACAGTTACAGCGTCAGC
CCCTCGCAAGACACAGATCGAGCAAGAAGCAGCATGGTCTCCACAGAAAGTGCCTCCTCCACTTACGAAGAACTGGCCAGGGCCTACGAA
CACGCCAAGATGGAAGAGCAACTGAGGCACGCCAAGTTCACCATCACGGAGTGCTTCATATCAGACACGTCATCGGAGCAGTTGACGGCA
GGGACAAATGAGTACACGGACAGTCTGACCTCCAGCACCCCTTCCGAATCGGGAATCTGCAGGTTCACTGCATCTCCCCCCAAACCTCAG
GATGGAGGAAGAGTAATGAATATGGCAGTTCCAAAGGCACATCGGCCAGGTGACCTCATACATTTGCCTCCATACCTTAGAATGGACTTT
TTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGAGCTTAGGACAAGCATGCTTGGAACCTCAGAAAAGCCGGACCCTGAAGCGC
CCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCTCCGCCTCCTCCACGAGAGAAGGACAGTCGTGGCAGCCGGGGGCCGTGGCC
ACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAGCTAAAATGAGCAGCTCCCAAGAATCACTGCTCGACTCCCGGGGCCATTTG
AAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTATAACAGACAGCATGACTGGACAGCGGTTGTAAATACAATTCAAACAATTCA
ATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATAATTAAAGAAAATTGCCAAAATATATTAAAAAAAAAAAAGAGAAAATACTG
AAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTGTCTGAGTGTGAGCTCCATCCGCCTGGGCATCTGATTTTTTGGGAAAGAAG
TCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTGATTTTCTACAAAAGTGCATGGGGGGGATTAATTAAACCTTCTGACTGGAA
GTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGTGGGAAATCAGCCTATTTGTGAATTTAAAAGGAACACCGATTTGCGGGCAG
GGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCATTAGAAACCGGGTTCTCAATTTGGTCTTCTTTTGTTGTTAATTAGGATGAG
TGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTCTCTCTTGTTTCTTTTTTAATTTAATGAGACACTCTTTGCATTTTGTCTAA
GCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCATGTCTGCTTCTCTCGTCTTCTGCCAGTGGCCTGGTCCTCCTTCCCATTGAC
ACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAATTCAATAAACCAGAGTCGATACTAACACCCTGAACTCCTCAGGAATCTCC
AGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGGAGAGGACAAAATGCAGGCTGGTCTCCACCGCAACCAGAGGCCAGCCCAAG
TATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCCATGGCCAGAGTTCAACTGACTGTGGCCTATGGGCCAAATCCAGCCTCCTG
CTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATGCACTATTTGCTATTGTCTATGGCTGCTTTCATGGCACAATGGTAGAGCTG
AATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAAATATTTATTACCTGGCCCATTACAGGAAACATTTGCCAGACCCGTGCTCT
GGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCAAGATCGTGCATCTTACCCTCCATGACTTTTCCTATCTCCACTATGCCTGG
TATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCTGAATCCTCTGTAACCAGAGGAAAGTGATGTTCCTCTAAAATCTAAGTTTT
TACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATCCTAAGAGAGAATTTACTCATAAATAGTCGGAACTGCATTCTTTATCCCAC
AACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCCTCCCCTGGCTGCAACACTCCATTCCAGGCTCACTTCCATAAAATGGAAAG
ATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGAAAACATGATCAAATATCCACAGCTGCTCAGTCTCCCAGGCTGAAGATTCT
CTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCCAGTTATTACCATCTTGGGAACATATTCAGAAATGTCTTTCCTTCCCTCCC
TCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTTTCCAGGCAGGCCCATTTGTCTGCTTAGATTCAGTGACACAGAATGGGTCC
AGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGATGACTCCAGGAATGTGAGGTGTGCATCCATGGTTTCAGAATGTAATCCGTG
TTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTTTTATGCAAAAGAAATGTTACTTTCTGGGGGAAAAAATTAAAAGTCTATCT
TTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAGTTTACCTTTTTAACATTTTTCTCTCAACCTGTACAAAAATAAAAAAATTC

>85787_85787_2_SPIDR-DSCAM_SPIDR_chr8_48206619_ENST00000518074_DSCAM_chr21_41559914_ENST00000400454_length(amino acids)=1276AA_BP=109
MAQSLTAEEKTITEKHLELCPRPKQETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQRDELQFIDWEIDSDRAEASDCDEFEDDEGAV
EISDCASCASNQSLTSDEKLSELPKILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPIT
GYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWK
APKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQ
AIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE
DVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII
TVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG
SDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNG
VGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYEL
QMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAE
MLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARP
GTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELAR
AYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLR
MDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDSR

--------------------------------------------------------------
>85787_85787_3_SPIDR-DSCAM_SPIDR_chr8_48206619_ENST00000541342_DSCAM_chr21_41559914_ENST00000400454_length(transcript)=5982nt_BP=461nt
GAGATGCCCCGCGGCAGCCGCGCTCGGGGCTCTAAGAGAAAAAGGAGTTGGAATACAGAATGCCCATCCTTTCCAGGAGAAAGACCACTG
CAGGTCAGAAGAGCAGGTCTCAGGACAGCAGGGGCAGCTGCCTCTCTCTCTGAAGCATGGCTCAGGTGTGGAGAAGGGTTTCAGAACACT
TCTGGGAATCCGAAACCACCACATCTAAAAGCACCAGTGGGCTTACAGACATAACATGGAGCTCCAGTGGAAGTGATTTGTCGGATGAAG
ATAAGACACTTTCTCAGTTACAGAGAGATGAATTACAGTTTATCGACTGGGAGATTGACAGTGACAGGGCAGAGGCTAGTGACTGTGATG
AATTTGAAGATGACGAGGGTGCTGTGGAAATCTCAGACTGTGCTTCTTGTGCAAGTAATCAGTCTTTGACAAGTGATGAGAAGCTGTCGG
AGCTTCCCAAGATTTTGCCAACTGTGAGAGAAGATTCTGGTTTCTTTTCCTGCCATGCTATTAATTCTTATGGGGAGGACCGTGGAATAA
TTCAGCTCACAGTGCAAGAGCCCCCAGACCCTCCCGAAATTGAGATCAAAGATGTCAAAGCACGCACAATTACGCTCAGGTGGACCATGG
GGTTTGATGGAAACAGTCCCATCACAGGCTACGATATTGAATGCAAAAATAAATCAGACTCCTGGGATTCTGCTCAGAGAACCAAAGATG
TTTCCCCTCAGCTGAACTCGGCCACCATCATTGATATCCACCCTTCCTCCACCTACAGCATCCGCATGTACGCCAAGAACCGGATTGGCA
AGAGCGAGCCCAGCAACGAGCTCACCATCACGGCGGACGAGGCAGCTCCTGATGGTCCACCTCAGGAAGTTCACCTGGAGCCTATATCAT
CTCAGAGCATCAGGGTCACATGGAAGGCTCCCAAGAAACATTTGCAAAATGGGATTATCCGTGGCTACCAAATAGGTTACCGAGAGTACA
GCACTGGGGGTAACTTCCAATTCAACATTATCAGTGTCGACACCAGCGGGGACAGTGAGGTTTACACCCTGGACAACCTGAATAAGTTCA
CTCAGTACGGCCTGGTGGTGCAGGCCTGTAACCGGGCCGGCACGGGGCCTTCTTCTCAGGAAATCATCACCACCACTCTCGAGGATGTGC
CCAGTTACCCCCCCGAAAATGTCCAAGCCATAGCAACATCACCAGAAAGCATATCAATATCCTGGTCCACACTTTCCAAGGAAGCCTTGA
ATGGAATTCTCCAGGGGTTCAGAGTCATTTACTGGGCCAACCTCATGGACGGAGAGCTGGGTGAGATTAAAAACATCACCACCACACAGC
CTTCACTGGAGCTGGACGGGCTGGAAAAGTACACCAACTACAGCATCCAGGTGCTGGCCTTCACCCGCGCAGGAGACGGGGTCAGGAGTG
AGCAGATCTTCACCCGGACCAAAGAGGATGTTCCAGGTCCTCCCGCGGGTGTGAAGGCAGCGGCGGCCTCAGCCTCCATGGTCTTTGTGT
CCTGGCTTCCCCCTCTCAAGCTGAACGGCATCATCCGAAAGTACACTGTATTCTGCTCCCACCCCTATCCCACAGTGATCAGCGAGTTTG
AGGCCTCTCCCGACTCGTTTTCCTACAGAATTCCCAACCTGAGTAGGAATCGTCAGTACAGCGTCTGGGTGGTGGCTGTTACTTCAGCCG
GAAGAGGCAACAGCAGTGAAATCATCACAGTCGAGCCACTAGCAAAAGCTCCTGCACGAATCCTGACCTTCAGTGGGACAGTGACTACTC
CATGGATGAAAGACATTGTCTTGCCTTGTAAGGCTGTTGGGGACCCTTCTCCTGCAGTCAAATGGATGAAAGACAGTAACGGGACACCCA
GTCTAGTAACGATTGATGGGCGGAGGAGCATCTTTAGCAACGGAAGCTTCATTATTCGCACGGTGAAAGCAGAAGACTCCGGCTATTACA
GCTGCATTGCCAATAACAACTGGGGATCTGATGAAATTATTTTAAACTTACAAGTACAAGTTCCACCAGATCAGCCTCGGCTTACAGTCT
CCAAGACCACGTCTTCCTCCATCACCCTTTCTTGGCTCCCTGGAGACAACGGGGGCAGCTCTATCAGAGGATACATACTGCAGTACTCCG
AGGACAATAGTGAGCAGTGGGGGAGTTTTCCAATCAGCCCCAGCGAACGTTCCTATCGCTTGGAAAATCTCAAATGTGGGACTTGGTATA
AGTTCACACTGACAGCCCAAAATGGAGTGGGCCCAGGGCGCATAAGTGAAATCATAGAAGCAAAGACCTTAGGAAAAGAGCCCCAGTTCT
CAAAGGAGCAGGAGCTGTTTGCCAGCATCAACACCACACGCGTGAGGCTGAACCTCATTGGCTGGAATGATGGCGGCTGCCCCATCACCT
CCTTCACACTAGAGTACAGGCCCTTTGGGACCACAGTTTGGACCACAGCTCAGAGGACCTCTCTCTCCAAGTCCTACATCCTGTATGACC
TGCAGGAAGCCACCTGGTATGAGCTGCAGATGCGGGTGTGCAACAGTGCGGGCTGCGCGGAGAAGCAGGCCAACTTCGCTACGCTGAACT
ACGATGGCAGTACAATTCCTCCACTCATTAAGTCAGTTGTCCAAAACGAAGAAGGGCTGACGACCAACGAGGGGCTCAAGATGCTGGTGA
CCATCTCCTGTATCCTGGTGGGGGTCTTGCTGCTGTTTGTGCTCCTGCTGGTTGTGCGGAGGAGGCGGCGGGAGCAGAGGCTAAAGAGGC
TGCGAGATGCAAAGAGTTTAGCTGAAATGCTCATGAGTAAGAATACCCGGACTTCAGATACGTTAAGCAAGCAACAGCAGACCCTGCGAA
TGCACATCGACATACCCAGGGCTCAGCTTTTGATTGAAGAGAGAGACACGATGGAGACCATTGATGATCGCTCCACGGTTCTGTTGACGG
ATGCTGACTTTGGAGAGGCAGCTAAGCAGAAGTCCCTGACGGTCACTCACACGGTCCATTACCAATCGGTGTCTCAGGCCACTGGGCCCT
TAGTGGATGTTTCAGACGCTCGGCCGGGAACGAATCCCACCACCAGGAGGAATGCCAAGGCTGGGCCCACAGCGAGAAACCGCTATGCCA
GCCAGTGGACCCTCAACCGACCCCACCCCACCATCTCAGCACACACCCTCACCACAGACTGGAGGCTGCCAACACCCAGGGCTGCAGGAT
CAGTAGACAAAGAGAGCGACAGTTACAGCGTCAGCCCCTCGCAAGACACAGATCGAGCAAGAAGCAGCATGGTCTCCACAGAAAGTGCCT
CCTCCACTTACGAAGAACTGGCCAGGGCCTACGAACACGCCAAGATGGAAGAGCAACTGAGGCACGCCAAGTTCACCATCACGGAGTGCT
TCATATCAGACACGTCATCGGAGCAGTTGACGGCAGGGACAAATGAGTACACGGACAGTCTGACCTCCAGCACCCCTTCCGAATCGGGAA
TCTGCAGGTTCACTGCATCTCCCCCCAAACCTCAGGATGGAGGAAGAGTAATGAATATGGCAGTTCCAAAGGCACATCGGCCAGGTGACC
TCATACATTTGCCTCCATACCTTAGAATGGACTTTTTGTTAAACCGAGGTGGTCCAGGCACCAGCAGGGACCTGAGCTTAGGACAAGCAT
GCTTGGAACCTCAGAAAAGCCGGACCCTGAAGCGCCCCACGGTCCTGGAGCCCATCCCGATGGAAGCCGCCTCCTCCGCCTCCTCCACGA
GAGAAGGACAGTCGTGGCAGCCGGGGGCCGTGGCCACATTACCTCAGCGGGAGGGAGCAGAGCTGGGACAGGCAGCTAAAATGAGCAGCT
CCCAAGAATCACTGCTCGACTCCCGGGGCCATTTGAAAGGAAACAATCCTTACGCAAAATCTTACACCCTGGTATAACAGACAGCATGAC
TGGACAGCGGTTGTAAATACAATTCAAACAATTCAATCAAAGCTACCTTTTTTTTACGGAATTCCAATATTTATAATTAAAGAAAATTGC
CAAAATATATTAAAAAAAAAAAAGAGAAAATACTGAAACCACAGACAGTGCAAAGACTCTCCTGCTTTTTTTCTGTCTGAGTGTGAGCTC
CATCCGCCTGGGCATCTGATTTTTTGGGAAAGAAGTCCAGTTTTATGATCTTCACAGGCTATTGCATTTTTACTGATTTTCTACAAAAGT
GCATGGGGGGGATTAATTAAACCTTCTGACTGGAAGTTCTATCACACAAGAGGCAAGAAAGAAAACAGGGTGGGTGGGAAATCAGCCTAT
TTGTGAATTTAAAAGGAACACCGATTTGCGGGCAGGGGAAAACTTCAGTCACGTTTGCACACCTTTCTTTCCCATTAGAAACCGGGTTCT
CAATTTGGTCTTCTTTTGTTGTTAATTAGGATGAGTGCCGTCAGTGAAGGGGTGGGGGGAATCAATTTGGTTTTCTCTCTTGTTTCTTTT
TTAATTTAATGAGACACTCTTTGCATTTTGTCTAAGCGAAATAAAAAAGAAAAGGTTGTCTGCCTTTATTTCCATGTCTGCTTCTCTCGT
CTTCTGCCAGTGGCCTGGTCCTCCTTCCCATTGACACTTCTGTTTGGAAACACCAGGCCTGAACCCAGAGCCCAATTCAATAAACCAGAG
TCGATACTAACACCCTGAACTCCTCAGGAATCTCCAGGAAGCACAAAGAAGGTGCAGCTCCTGCTCTCAAGCTGGAGAGGACAAAATGCA
GGCTGGTCTCCACCGCAACCAGAGGCCAGCCCAAGTATTCGAAGCCCGTCGCAAAGCTCTGCCCCTTGCCTGCCCATGGCCAGAGTTCAA
CTGACTGTGGCCTATGGGCCAAATCCAGCCTCCTGCTGTTTTTTAAATAAAGTTTTATTGAAACAAGGCCACATGCACTATTTGCTATTG
TCTATGGCTGCTTTCATGGCACAATGGTAGAGCTGAATAGTTGCAGCAGAGATGGTATAGCCCATGAAGCCTAAAATATTTATTACCTGG
CCCATTACAGGAAACATTTGCCAGACCCGTGCTCTGGAGTCTGAAATGTAGCCCCAGCTTGCGTGACAAGGGGCAAGATCGTGCATCTTA
CCCTCCATGACTTTTCCTATCTCCACTATGCCTGGTATGCAAATTTGTGATAGACCATCTTAATAAACATTGCCTGAATCCTCTGTAACC
AGAGGAAAGTGATGTTCCTCTAAAATCTAAGTTTTTACTTTCCTTTCCCTCACTTTATCTCCCATGTGGCTCATCCTAAGAGAGAATTTA
CTCATAAATAGTCGGAACTGCATTCTTTATCCCACAACCCTCACAGGGTTTGCTTTATGAAAGAGGATGTAATCCTCCCCTGGCTGCAAC
ACTCCATTCCAGGCTCACTTCCATAAAATGGAAAGATAAACAGGTCTTTGTGTCAGAGATTTGGCATTAACCAGAAAACATGATCAAATA
TCCACAGCTGCTCAGTCTCCCAGGCTGAAGATTCTCTACAGGCTTCCATTAAGGCCACCAACATAGACTGGTGCCAGTTATTACCATCTT
GGGAACATATTCAGAAATGTCTTTCCTTCCCTCCCTCCCTCCTTCTTTCCCATCCTTTCTTCCTTCTATTTATTTTCCAGGCAGGCCCAT
TTGTCTGCTTAGATTCAGTGACACAGAATGGGTCCAGGACCATGTCAAGACCACCTGCTGATGCTAGTGTTAGATGACTCCAGGAATGTG
AGGTGTGCATCCATGGTTTCAGAATGTAATCCGTGTTGACGTGTACTGTTTGCATACTCTCAGACTGTTTTTTTTTTATGCAAAAGAAAT
GTTACTTTCTGGGGGAAAAAATTAAAAGTCTATCTTTCATCAACCTAAAACTTCTATATCCCCCAAACATAGAAGTTTACCTTTTTAACA

>85787_85787_3_SPIDR-DSCAM_SPIDR_chr8_48206619_ENST00000541342_DSCAM_chr21_41559914_ENST00000400454_length(amino acids)=1266AA_BP=99
MAQVWRRVSEHFWESETTTSKSTSGLTDITWSSSGSDLSDEDKTLSQLQRDELQFIDWEIDSDRAEASDCDEFEDDEGAVEISDCASCAS
NQSLTSDEKLSELPKILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKS
DSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGI
IRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESIS
ISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVK
AAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPA
RILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV
QVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEII
EAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGC
AEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTS
DTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNA
KAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQ
LRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGP
GTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPYA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPIDR-DSCAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPIDR-DSCAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPIDR-DSCAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource