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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AZGP1-CAPRIN2 (FusionGDB2 ID:8584)

Fusion Gene Summary for AZGP1-CAPRIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: AZGP1-CAPRIN2
Fusion gene ID: 8584
HgeneTgene
Gene symbol

AZGP1

CAPRIN2

Gene ID

563

65981

Gene namealpha-2-glycoprotein 1, zinc-bindingcaprin family member 2
SynonymsZA2G|ZAGC1QDC1|EEG-1|EEG1|RNG140
Cytomap

7q22.1

12p11.21

Type of geneprotein-codingprotein-coding
Descriptionzinc-alpha-2-glycoproteinAlpha-2-glycoprotein, zincZn-alpha2-glycoproteintesticular tissue protein Li 227zn-alpha-2-GPzn-alpha-2-glycoproteincaprin-2C1q domain-containing protein 1RNA granule protein 140cytoplasmic activation/proliferation-associated protein 2gastric cancer multidrug resistance-associated protein
Modification date2020031320200313
UniProtAcc

P25311

Q6IMN6

Ensembl transtripts involved in fusion geneENST00000292401, ENST00000411734, 
ENST00000483612, 		ENST00000298892, 
ENST00000251071, ENST00000308433, 
ENST00000395805, ENST00000417045, 
ENST00000538387, 
Fusion gene scores* DoF score6 X 6 X 2=724 X 9 X 4=144
# samples 108
** MAII scorelog2(10/72*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AZGP1 [Title/Abstract] AND CAPRIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAZGP1(99573584)-CAPRIN2(30863313), # samples:1
AZGP1(99573584)-CAPRIN2(30863309), # samples:1
AZGP1(99573583)-CAPRIN2(30863267), # samples:1
AZGP1(99573583)-CAPRIN2(30863246), # samples:1
AZGP1(99573584)-CAPRIN2(30863228), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAZGP1

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

24248522

HgeneAZGP1

GO:0007155

cell adhesion

9813179

TgeneCAPRIN2

GO:0030308

negative regulation of cell growth

14593112

TgeneCAPRIN2

GO:0032092

positive regulation of protein binding

18762581

TgeneCAPRIN2

GO:0033138

positive regulation of peptidyl-serine phosphorylation

18762581

TgeneCAPRIN2

GO:0045944

positive regulation of transcription by RNA polymerase II

18762581

TgeneCAPRIN2

GO:0090263

positive regulation of canonical Wnt signaling pathway

18762581


check buttonFusion gene breakpoints across AZGP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAPRIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAX795402AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
ChiTaRS5.0N/AAX795404AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
ChiTaRS5.0N/AAX795406AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
ChiTaRS5.0N/AAX795408AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
ChiTaRS5.0N/AAX795410AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-


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Fusion Gene ORF analysis for AZGP1-CAPRIN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000292401ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000411734ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000483612ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-intronENST00000292401ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000292401ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000292401ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000411734ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000411734ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000411734ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000483612ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000483612ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000483612ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AZGP1-CAPRIN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AZGP1-CAPRIN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:99573584/:30863313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AZGP1

P25311

CAPRIN2

Q6IMN6

FUNCTION: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.FUNCTION: Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). {ECO:0000250|UniProtKB:Q05A80, ECO:0000269|PubMed:14593112, ECO:0000269|PubMed:18762581, ECO:0000269|PubMed:27821587}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AZGP1-CAPRIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AZGP1-CAPRIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AZGP1-CAPRIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AZGP1-CAPRIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource