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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPINT2-SIPA1L3 (FusionGDB2 ID:85852)

Fusion Gene Summary for SPINT2-SIPA1L3

check button Fusion gene summary
Fusion gene informationFusion gene name: SPINT2-SIPA1L3
Fusion gene ID: 85852
HgeneTgene
Gene symbol

SPINT2

SIPA1L3

Gene ID

10653

23094

Gene nameserine peptidase inhibitor, Kunitz type 2signal induced proliferation associated 1 like 3
SynonymsDIAR3|HAI-2|HAI2|Kop|PBCTRCT45|SPAL3|SPAR3
Cytomap

19q13.2

19q13.13-q13.2

Type of geneprotein-codingprotein-coding
Descriptionkunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183signal-induced proliferation-associated 1-like protein 3SIPA1-like protein 3SPA-1-like protein 3spine-associated RapGAP 3
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000301244, ENST00000587090, 
ENST00000454580, 
ENST00000222345, 
ENST00000476317, 
Fusion gene scores* DoF score16 X 8 X 9=115230 X 26 X 13=10140
# samples 2135
** MAII scorelog2(21/1152*10)=-2.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(35/10140*10)=-4.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPINT2 [Title/Abstract] AND SIPA1L3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPINT2(38774437)-SIPA1L3(38698692), # samples:1
SPINT2(38755638)-SIPA1L3(38689029), # samples:1
SPINT2(38755638)-SIPA1L3(38597177), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPINT2

GO:0022408

negative regulation of cell-cell adhesion

19592578

HgeneSPINT2

GO:2000146

negative regulation of cell motility

19592578

TgeneSIPA1L3

GO:0003382

epithelial cell morphogenesis

26231217

TgeneSIPA1L3

GO:0090162

establishment of epithelial cell polarity

26231217


check buttonFusion gene breakpoints across SPINT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SIPA1L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-AARQSPINT2chr19

38774437

+SIPA1L3chr19

38698692

+
ChimerDB4READTCGA-EI-6506SPINT2chr19

38755638

+SIPA1L3chr19

38689029

+
ChimerDB4STADTCGA-BR-A4PE-01ASPINT2chr19

38755638

+SIPA1L3chr19

38597177

+


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Fusion Gene ORF analysis for SPINT2-SIPA1L3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000301244ENST00000222345SPINT2chr19

38774437

+SIPA1L3chr19

38698692

+
5CDS-3UTRENST00000587090ENST00000222345SPINT2chr19

38774437

+SIPA1L3chr19

38698692

+
5CDS-intronENST00000301244ENST00000476317SPINT2chr19

38774437

+SIPA1L3chr19

38698692

+
5CDS-intronENST00000301244ENST00000476317SPINT2chr19

38755638

+SIPA1L3chr19

38689029

+
5CDS-intronENST00000301244ENST00000476317SPINT2chr19

38755638

+SIPA1L3chr19

38597177

+
5CDS-intronENST00000454580ENST00000476317SPINT2chr19

38755638

+SIPA1L3chr19

38689029

+
5CDS-intronENST00000454580ENST00000476317SPINT2chr19

38755638

+SIPA1L3chr19

38597177

+
5CDS-intronENST00000587090ENST00000476317SPINT2chr19

38774437

+SIPA1L3chr19

38698692

+
In-frameENST00000301244ENST00000222345SPINT2chr19

38755638

+SIPA1L3chr19

38689029

+
In-frameENST00000301244ENST00000222345SPINT2chr19

38755638

+SIPA1L3chr19

38597177

+
In-frameENST00000454580ENST00000222345SPINT2chr19

38755638

+SIPA1L3chr19

38689029

+
In-frameENST00000454580ENST00000222345SPINT2chr19

38755638

+SIPA1L3chr19

38597177

+
intron-3CDSENST00000587090ENST00000222345SPINT2chr19

38755638

+SIPA1L3chr19

38689029

+
intron-3CDSENST00000587090ENST00000222345SPINT2chr19

38755638

+SIPA1L3chr19

38597177

+
intron-3UTRENST00000454580ENST00000222345SPINT2chr19

38774437

+SIPA1L3chr19

38698692

+
intron-intronENST00000454580ENST00000476317SPINT2chr19

38774437

+SIPA1L3chr19

38698692

+
intron-intronENST00000587090ENST00000476317SPINT2chr19

38755638

+SIPA1L3chr19

38689029

+
intron-intronENST00000587090ENST00000476317SPINT2chr19

38755638

+SIPA1L3chr19

38597177

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000301244SPINT2chr1938755638+ENST00000222345SIPA1L3chr1938597177+599054141138571148
ENST00000454580SPINT2chr1938755638+ENST00000222345SIPA1L3chr1938597177+587242329337391148

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000301244ENST00000222345SPINT2chr1938755638+SIPA1L3chr1938597177+0.0057645680.99423546
ENST00000454580ENST00000222345SPINT2chr1938755638+SIPA1L3chr1938597177+0.0048145780.99518543

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Fusion Genomic Features for SPINT2-SIPA1L3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPINT2chr1938755638+SIPA1L3chr1938689028+7.68E-060.9999924
SPINT2chr1938755638+SIPA1L3chr1938597176+1.43E-111
SPINT2chr1938755638+SIPA1L3chr1938689028+7.68E-060.9999924
SPINT2chr1938755638+SIPA1L3chr1938597176+1.43E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPINT2-SIPA1L3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:38774437/chr19:38698692)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSIPA1L3chr19:38755638chr19:38597177ENST000002223455221720_17746761782.0Coiled coilOntology_term=ECO:0000255
TgeneSIPA1L3chr19:38755638chr19:38689029ENST0000022234517221720_177416131782.0Coiled coilOntology_term=ECO:0000255
TgeneSIPA1L3chr19:38755638chr19:38597177ENST00000222345522966_10426761782.0DomainPDZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPINT2chr19:38755638chr19:38597177ENST00000301244+17219_25235253.0Topological domainCytoplasmic
HgeneSPINT2chr19:38755638chr19:38597177ENST00000301244+1728_19735253.0Topological domainExtracellular
HgeneSPINT2chr19:38755638chr19:38597177ENST00000454580+16219_25235196.0Topological domainCytoplasmic
HgeneSPINT2chr19:38755638chr19:38597177ENST00000454580+1628_19735196.0Topological domainExtracellular
HgeneSPINT2chr19:38755638chr19:38689029ENST00000301244+17219_25235253.0Topological domainCytoplasmic
HgeneSPINT2chr19:38755638chr19:38689029ENST00000301244+1728_19735253.0Topological domainExtracellular
HgeneSPINT2chr19:38755638chr19:38689029ENST00000454580+16219_25235196.0Topological domainCytoplasmic
HgeneSPINT2chr19:38755638chr19:38689029ENST00000454580+1628_19735196.0Topological domainExtracellular
HgeneSPINT2chr19:38755638chr19:38597177ENST00000301244+17198_21835253.0TransmembraneHelical
HgeneSPINT2chr19:38755638chr19:38597177ENST00000454580+16198_21835196.0TransmembraneHelical
HgeneSPINT2chr19:38755638chr19:38689029ENST00000301244+17198_21835253.0TransmembraneHelical
HgeneSPINT2chr19:38755638chr19:38689029ENST00000454580+16198_21835196.0TransmembraneHelical
TgeneSIPA1L3chr19:38755638chr19:38597177ENST00000222345522611_8286761782.0DomainRap-GAP
TgeneSIPA1L3chr19:38755638chr19:38689029ENST000002223451722611_82816131782.0DomainRap-GAP
TgeneSIPA1L3chr19:38755638chr19:38689029ENST000002223451722966_104216131782.0DomainPDZ


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Fusion Gene Sequence for SPINT2-SIPA1L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85852_85852_1_SPINT2-SIPA1L3_SPINT2_chr19_38755638_ENST00000301244_SIPA1L3_chr19_38597177_ENST00000222345_length(transcript)=5990nt_BP=541nt
GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT
CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC
GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC
GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT
TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC
GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC
GCCGACTCCACGGGAACCCACTCCCTCTACACGATGTACCAGGACTACGAGATCATGTTCCATGTCTCCACCCTGCTCCCTTACACCCCC
AACAACAGGCAGCAGCTGCTACGGAAGAGGCACATAGGAAATGACATCGTGACGATCATCTTCCAGGAGCCTGGCGCGCTACCGTTCACC
CCCAAGAACATCCGCTCCCACTTCCAGCACGTCTTCATCATTGTCCGAGTCCACAACCCCTGCACTGATAACGTCTGTTACAGTATGGCT
GTGACCCGATCCAAAGACGCTCCTCCTTTCGGCCCCCCCATCCCCAGTGGAACCACATTCCGCAAATCCGACGTCTTCAGAGACTTCTTG
CTGGCCAAGGTGATTAACGCTGAGAACGCCGCGCACAAGTCCGACAAGTTCCACACCATGGCCACCAGGACCCGCCAGGAGTATCTCAAG
GACCTGGCCGAAAACTGTGTCTCCAACACCCCCATCGACTCCACCGGCAAATTCAACCTCATCTCCCTGACCTCCAAGAAGAAGGAAAAG
ACAAAAGCACGGGCTGGCGCTGAGCAGCACAGTGCAGGGGCCATCGCCTGGAGGGTGGTGGCCCAGGACTACGCCCAGGGGGTGGAAATC
GACTGCATTTTGGGAATTTCCAATGAGTTTGTGGTGCTCCTGGACTTACGCACCAAGGAGGTGGTGTTCAACTGCTACTGCGGGGATGTC
ATTGGCTGGACTCCAGACTCCTCCACACTCAAAATCTTCTATGGACGAGGAGACCACATCTTCCTACAGGCGACAGAGGGTTCTGTGGAG
GACATAAGGGAGATAGTGCAGAGACTGAAGGTGATGACCAGTGGCTGGGAGACGGTGGACATGACGCTTCGGCGGAACGGGCTCGGGCAG
CTGGGCTTCCACGTGAAGTACGACGGCACGGTGGCCGAGGTTGAGGACTATGGGTTCGCCTGGCAGGCCGGCCTCCGGCAGGGCAGCCGA
CTAGTGGAGATCTGCAAGGTGGCCGTGGTCACACTGACCCACGACCAGATGATCGACCTGCTGCGCACCTCTGTCACTGTGAAGGTGGTC
ATCATCCCGCCTTTTGAGGACGGCACTCCCCGGAGGGGTTGGCCGGAGACCTACGACATGAATACCTCGGAGCCCAAGACGGAGCAGGAA
AGCATCACTCCTGGGGGCCGGCCCCCCTACCGCAGCAATGCTCCCTGGCAGTGGAGCGGGCCCGCATCCCATAACTCTCTACCAGCCTCC
AAGTGGGCCACTCCAACCACTCCCGGCCATGCCCAGTCCCTGAGCCGGCCCCTGAAGCAGACCCCCATAGTCCCCTTCCGGGAGTCCCAG
CCACTGCACAGCAAGAGGCCTGTCAGCTTCCCAGAAACCCCTTACACAGTATCACCAGCAGGGGCCGACAGAGTCCCTCCCTACCGACAG
CCTTCTGGGAGCTTCTCCACCCCCGGTTCGGCCACCTACGTGAGATACAAGCCATCCCCAGAAAGGTACACGGCTGCCCCACACCCCCTG
CTATCTCTTGATCCCCACTTCAGCCACGATGGGACGTCCAGCGGCGACTCCTCTTCCGGCGGCCTGACCAGCCAGGAGAGCACCATGGAA
CGCCAGAAGCCAGAGCCTTTGTGGCATGTGCCTGCCCAGGCCAGGCTCTCAGCCATAGCCGGAAGCAGCGGGAACAAGCACCCGTCCAGG
CAGGATGCAGCAGGCAAAGATTCCCCCAACAGGCATTCCAAAGGAGAACCTCAATACTCAAGTCATTCCAGCAGCAACACCCTCTCCAGC
AACGCATCCAGCAGCCACAGCGACGACCGCTGGTTCGACCCCCTGGACCCCCTGGAGCCAGAGCAAGACCCCCTCTCCAAGGGTGGCTCT
AGTGACAGCGGCATCGACACCACCCTCTACACCTCCAGCCCTAGCTGCATGTCCCTGGCCAAGGCTCCACGGCCCGCCAAGCCACACAAG
CCCCCTGGAAGTATGGGCCTTTGTGGCGGGGGTCGCGAGGCCGCTGGGAGGTCCCACCACGCAGACAGGCGGCGGGAGGTCTCCCCTGCC
CCCGCAGTTGCCGGCCAAAGCAAGGGCTACCGACCGAAGCTGTACTCCTCCGGCTCCAGCACCCCCACGGGACTGGCGGGGGGCAGCCGA
GACCCACCGAGGCAGCCCAGTGACATGGGCTCGAGGGTTGGCTACCCCGCTCAGGTTTACAAAACTGCCAGTGCAGAGACTCCTCGGCCC
TCCCAGCTGGCCCAGCCCAGCCCCTTTCAGCTCTCCGCCTCCGTCCCCAAGTCCTTCTTCTCCAAGCAGCCTGTACGCAATAAGCACCCA
ACAGGGTGGAAGAGAACGGAGGAGCCCCCACCACGGCCACTCCCCTTCAGTGACCCAAAGAAGCAGGTGGACACGAACACCAAAAATGTC
TTTGGGCAACCGAGGTTGAGGGCATCCCTCCGAGACCTCCGGTCACCACGGAAGAACTACAAATCCACCATCGAGGATGACCTGAAGAAA
CTCATCATCATGGACAACCTGGGGCCAGAGCAGGAGAGAGACACGGGACAGTCACCGCAGAAGGGCCTGCAGCGGACGCTGTCGGACGAG
AGCCTGTGCAGCGGGCGCCGGGAGCCCAGCTTCGCCAGCCCCGCTGGCCTAGAGCCAGGGCTGCCCAGCGACGTGCTCTTCACCAGCACC
TGCGCCTTCCCGTCCAGCACGCTGCCTGCACGCCGCCAGCACCAGCACCCCCACCCGCCCGTCGGCCCCGGTGCCACCCCTGCCGCCGGC
AGCGGCTTTCCCGAGAAGAAATCCACCATCTCAGCCTCGGAGCTCTCGCTGGCTGATGGGCGGGACCGCCCCCTGCGGCGCCTGGACCCT
GGGCTGATGCCCCTGCCTGACACAGCTGCTGGCCTCGAGTGGTCCAGCCTGGTGAACGCAGCCAAGGCATACGAAGTGCAAAGAGCCGTC
TCACTCTTCTCTCTGAACGACCCGGCCCTGAGCCCGGACATCCCGCCTGCACACAGTCCTGTCCACAGCCACCTGAGCCTGGAGAGGGGA
CCCCCGACCCCCAGGACCACCCCTACCATGAGCGAGGAGCCACCCCTGGATCTGACAGGCAAGGTGTACCAGCTGGAGGTGATGCTGAAA
CAGCTGCACACTGACCTGCAGAAGGAGAAGCAGGACAAGGTGGTGCTCCAGTCAGAGGTGGCCAGCCTGCGGCAGAACAACCAGCGGCTG
CAGGAGGAGTCGCAGGCCGCCAGCGAGCAGCTGCGCAAGTTTGCGGAGATCTTCTGCAGGGAGAAGAAGGAGCTCTGAGGTGGGAGGCCG
CCGCCCGCCTTCGCTCCTTCCCCTCAGGCCGTGGCCCTGCTGCCTCTCTCCCTCCACTCAGCTCCCAGCTGCCGGTGTGACCAAGATGAC
CCATCCAGGGCCCTCCCCATGGACACGGAAACTCCGATGGCCTCACTAGGGCTGTGAGTCAGGGTCAGCGCGCACAGCCCTCATGCCCCA
GAGGGCGAAGTGGTCTCAGGCCTCCCTCCAAGCTGCCCAGCTGTGGTCCCGGTGAGCTGGGCTGTGCTTACACCGCTCCCGGGCCTGCCC
CGCTGTCCCCATCTAGCCTCTTCCTGGGACCAGCCCTTCGAAGCTGATGGGGACGGAGAGAGGAGCCAGTCTCCAGACGCCTCGGCTCCA
GGAGGTCACACAGCAGGTTTCTGCACCACGCACAACAAAGTTGCGGCTTGTGGGGCCGAGGCCCCTGCATGAAAAGTACAGCGTGAAAGC
AACCCTTTCTTCCCCACACCCAGAGAGGTGAGGCCCGCGTGGACACAGACCAGGGCGCCTCGGTCCCTAGCACGTGAGCTCCAAAAAGCA
CGAACATGATCCCCTCCCTAACCCCCTCCTCCCAAAAAGCAGCCAGGAGCACTTTCTTAGAGTTTAAATTATTTTCTTGGGGGCCTGAGG
ATAGAGAGAGGCAAGGCTAGCCTCCAGAGCCGATTTATTTGAGAGAGAAACTCTATTTGGATCTCCAGGACGGTTTATACGATCTTTTTC
TATCAGCTCCTCTTCCGCCAGAGGCCACTGCACCTGGGCTAGGGGTCCACAGGCCCCTCCACCTTCCAGCTAACCAGGCCAGGCCGGGGC
GGTGGAGCCACCACACAGCCGACTCTCTCCTCCTCCTCCCGGCACGACCTGGCCCTGACCAGCAGCCTCGGCCTCTTCTGGGTTCCAGGA
GGGGCTCCCGAAGCCCTCAGGACAGGGCTGGAGGAGAACAGCCTTCATCTCCTCCTCTGGTTTTTTTTTCCTTTGCAAGTCTCCCAGCCC
ATCTCTCCGAGCAGCGGCCACCAGACCCCCTCACCATGCTCCCCGGGGAGCACTGCACCCCGCGAACCCCACTGGACGCTGGTTCTCTAA
AGGCAATAAGGGGCGGCCATGCCGGTGTGGTACCACGCTGTTCCTCCAGGAAACCGTTTCTTTTTTTCCTTCTTTAAAAGCAAACAGAAA
AAGATATATATATATATATATATATATTTATTTTTTCATGTAGAGTTGGCGCCAGAACAAGCCTGTATGGCCACAGTCTGTGGATTCATC
CCCCCAACCTCAAGCTGAGGACCAAGGCGTGTCCCCTGTGGGCTGGGGGTCAGTGGGAGGACCAGAGGGATGAAGTCAGGGCAGGCCGGT
GCCCTTTTTGGGAGGCACCAGGCGGGGAGGAGTTGGCGGAGCAGGTCTGGCTGTGAGCCAGCACCAGGCAACCCGGCCCTTGTCCAGGGA
CCTCTGCTGCCTTCTCTCTGGGGTCAGGAACCTCAGAGGAGGGGGCTCTGGGGACTGCATAGGACGCAGGCACTCGGAGGTGCCGGTGTG
GATGGGTGGGGGTGAGAGAAGAGGGTTCTTATCGCGTCTCCTGTGATCAGCCTCTGGCCCCCTGGAGGAGGAAACCTCAGCGCTGCCCCT
GCCCCCACCCTCACCCCCAACACCAAGAGTGAGGTGGGCGTGCCCCAGGCAGCGTCCTCAGCCCTGGCCAGCTACTGTGATGCCATCTTC
TCCCCCATCCCCTTCTCTGGGGGGCCCACCCGTCCCCCACCCCCACCCCTTAGACCCTCATCGGGTCCCTTTTTTTTTTTTTTTTTCAGT
TGTCTCCTCCCATCTTCAGATCATTCGAATCATTTTGGGGACTTAATCATGTACATGGACAAGTGTAAATTATGATTTTTGGTTTTGTTT
TCTGTTATTTTTTAAGGATTTCTGCAAAAACAGATCTATTTAATTTGAGGTTGATGTTCTATCCAATGGCCGAAGATAGCAGCAGGTTTT
TTTTTTCATATGTTGATTTGTTTCATTTGGATTTTTTTTTTATTATTCTTTATTGTCTTTTTTTTTTCCCCATCCCTGTCTTGAGATTTT

>85852_85852_1_SPINT2-SIPA1L3_SPINT2_chr19_38755638_ENST00000301244_SIPA1L3_chr19_38597177_ENST00000222345_length(amino acids)=1148AA_BP=43
MRVSAELAMAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHADSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIV
TIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAENAAHKSDKF
HTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLR
TKEVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDY
GFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQ
WSGPASHNSLPASKWATPTTPGHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFPETPYTVSPAGADRVPPYRQPSGSFSTPGSATYVRYK
PSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQKPEPLWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSKGEP
QYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPLSKGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGR
SHHADRRREVSPAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSRDPPRQPSDMGSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSASVPK
SFFSKQPVRNKHPTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQ
SPQKGLQRTLSDESLCSGRREPSFASPAGLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASELSL
ADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLD

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>85852_85852_2_SPINT2-SIPA1L3_SPINT2_chr19_38755638_ENST00000454580_SIPA1L3_chr19_38597177_ENST00000222345_length(transcript)=5872nt_BP=423nt
ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG
AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA
CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG
ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG
CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGCCGACTCCACGGGAACCCACTCCCTCT
ACACGATGTACCAGGACTACGAGATCATGTTCCATGTCTCCACCCTGCTCCCTTACACCCCCAACAACAGGCAGCAGCTGCTACGGAAGA
GGCACATAGGAAATGACATCGTGACGATCATCTTCCAGGAGCCTGGCGCGCTACCGTTCACCCCCAAGAACATCCGCTCCCACTTCCAGC
ACGTCTTCATCATTGTCCGAGTCCACAACCCCTGCACTGATAACGTCTGTTACAGTATGGCTGTGACCCGATCCAAAGACGCTCCTCCTT
TCGGCCCCCCCATCCCCAGTGGAACCACATTCCGCAAATCCGACGTCTTCAGAGACTTCTTGCTGGCCAAGGTGATTAACGCTGAGAACG
CCGCGCACAAGTCCGACAAGTTCCACACCATGGCCACCAGGACCCGCCAGGAGTATCTCAAGGACCTGGCCGAAAACTGTGTCTCCAACA
CCCCCATCGACTCCACCGGCAAATTCAACCTCATCTCCCTGACCTCCAAGAAGAAGGAAAAGACAAAAGCACGGGCTGGCGCTGAGCAGC
ACAGTGCAGGGGCCATCGCCTGGAGGGTGGTGGCCCAGGACTACGCCCAGGGGGTGGAAATCGACTGCATTTTGGGAATTTCCAATGAGT
TTGTGGTGCTCCTGGACTTACGCACCAAGGAGGTGGTGTTCAACTGCTACTGCGGGGATGTCATTGGCTGGACTCCAGACTCCTCCACAC
TCAAAATCTTCTATGGACGAGGAGACCACATCTTCCTACAGGCGACAGAGGGTTCTGTGGAGGACATAAGGGAGATAGTGCAGAGACTGA
AGGTGATGACCAGTGGCTGGGAGACGGTGGACATGACGCTTCGGCGGAACGGGCTCGGGCAGCTGGGCTTCCACGTGAAGTACGACGGCA
CGGTGGCCGAGGTTGAGGACTATGGGTTCGCCTGGCAGGCCGGCCTCCGGCAGGGCAGCCGACTAGTGGAGATCTGCAAGGTGGCCGTGG
TCACACTGACCCACGACCAGATGATCGACCTGCTGCGCACCTCTGTCACTGTGAAGGTGGTCATCATCCCGCCTTTTGAGGACGGCACTC
CCCGGAGGGGTTGGCCGGAGACCTACGACATGAATACCTCGGAGCCCAAGACGGAGCAGGAAAGCATCACTCCTGGGGGCCGGCCCCCCT
ACCGCAGCAATGCTCCCTGGCAGTGGAGCGGGCCCGCATCCCATAACTCTCTACCAGCCTCCAAGTGGGCCACTCCAACCACTCCCGGCC
ATGCCCAGTCCCTGAGCCGGCCCCTGAAGCAGACCCCCATAGTCCCCTTCCGGGAGTCCCAGCCACTGCACAGCAAGAGGCCTGTCAGCT
TCCCAGAAACCCCTTACACAGTATCACCAGCAGGGGCCGACAGAGTCCCTCCCTACCGACAGCCTTCTGGGAGCTTCTCCACCCCCGGTT
CGGCCACCTACGTGAGATACAAGCCATCCCCAGAAAGGTACACGGCTGCCCCACACCCCCTGCTATCTCTTGATCCCCACTTCAGCCACG
ATGGGACGTCCAGCGGCGACTCCTCTTCCGGCGGCCTGACCAGCCAGGAGAGCACCATGGAACGCCAGAAGCCAGAGCCTTTGTGGCATG
TGCCTGCCCAGGCCAGGCTCTCAGCCATAGCCGGAAGCAGCGGGAACAAGCACCCGTCCAGGCAGGATGCAGCAGGCAAAGATTCCCCCA
ACAGGCATTCCAAAGGAGAACCTCAATACTCAAGTCATTCCAGCAGCAACACCCTCTCCAGCAACGCATCCAGCAGCCACAGCGACGACC
GCTGGTTCGACCCCCTGGACCCCCTGGAGCCAGAGCAAGACCCCCTCTCCAAGGGTGGCTCTAGTGACAGCGGCATCGACACCACCCTCT
ACACCTCCAGCCCTAGCTGCATGTCCCTGGCCAAGGCTCCACGGCCCGCCAAGCCACACAAGCCCCCTGGAAGTATGGGCCTTTGTGGCG
GGGGTCGCGAGGCCGCTGGGAGGTCCCACCACGCAGACAGGCGGCGGGAGGTCTCCCCTGCCCCCGCAGTTGCCGGCCAAAGCAAGGGCT
ACCGACCGAAGCTGTACTCCTCCGGCTCCAGCACCCCCACGGGACTGGCGGGGGGCAGCCGAGACCCACCGAGGCAGCCCAGTGACATGG
GCTCGAGGGTTGGCTACCCCGCTCAGGTTTACAAAACTGCCAGTGCAGAGACTCCTCGGCCCTCCCAGCTGGCCCAGCCCAGCCCCTTTC
AGCTCTCCGCCTCCGTCCCCAAGTCCTTCTTCTCCAAGCAGCCTGTACGCAATAAGCACCCAACAGGGTGGAAGAGAACGGAGGAGCCCC
CACCACGGCCACTCCCCTTCAGTGACCCAAAGAAGCAGGTGGACACGAACACCAAAAATGTCTTTGGGCAACCGAGGTTGAGGGCATCCC
TCCGAGACCTCCGGTCACCACGGAAGAACTACAAATCCACCATCGAGGATGACCTGAAGAAACTCATCATCATGGACAACCTGGGGCCAG
AGCAGGAGAGAGACACGGGACAGTCACCGCAGAAGGGCCTGCAGCGGACGCTGTCGGACGAGAGCCTGTGCAGCGGGCGCCGGGAGCCCA
GCTTCGCCAGCCCCGCTGGCCTAGAGCCAGGGCTGCCCAGCGACGTGCTCTTCACCAGCACCTGCGCCTTCCCGTCCAGCACGCTGCCTG
CACGCCGCCAGCACCAGCACCCCCACCCGCCCGTCGGCCCCGGTGCCACCCCTGCCGCCGGCAGCGGCTTTCCCGAGAAGAAATCCACCA
TCTCAGCCTCGGAGCTCTCGCTGGCTGATGGGCGGGACCGCCCCCTGCGGCGCCTGGACCCTGGGCTGATGCCCCTGCCTGACACAGCTG
CTGGCCTCGAGTGGTCCAGCCTGGTGAACGCAGCCAAGGCATACGAAGTGCAAAGAGCCGTCTCACTCTTCTCTCTGAACGACCCGGCCC
TGAGCCCGGACATCCCGCCTGCACACAGTCCTGTCCACAGCCACCTGAGCCTGGAGAGGGGACCCCCGACCCCCAGGACCACCCCTACCA
TGAGCGAGGAGCCACCCCTGGATCTGACAGGCAAGGTGTACCAGCTGGAGGTGATGCTGAAACAGCTGCACACTGACCTGCAGAAGGAGA
AGCAGGACAAGGTGGTGCTCCAGTCAGAGGTGGCCAGCCTGCGGCAGAACAACCAGCGGCTGCAGGAGGAGTCGCAGGCCGCCAGCGAGC
AGCTGCGCAAGTTTGCGGAGATCTTCTGCAGGGAGAAGAAGGAGCTCTGAGGTGGGAGGCCGCCGCCCGCCTTCGCTCCTTCCCCTCAGG
CCGTGGCCCTGCTGCCTCTCTCCCTCCACTCAGCTCCCAGCTGCCGGTGTGACCAAGATGACCCATCCAGGGCCCTCCCCATGGACACGG
AAACTCCGATGGCCTCACTAGGGCTGTGAGTCAGGGTCAGCGCGCACAGCCCTCATGCCCCAGAGGGCGAAGTGGTCTCAGGCCTCCCTC
CAAGCTGCCCAGCTGTGGTCCCGGTGAGCTGGGCTGTGCTTACACCGCTCCCGGGCCTGCCCCGCTGTCCCCATCTAGCCTCTTCCTGGG
ACCAGCCCTTCGAAGCTGATGGGGACGGAGAGAGGAGCCAGTCTCCAGACGCCTCGGCTCCAGGAGGTCACACAGCAGGTTTCTGCACCA
CGCACAACAAAGTTGCGGCTTGTGGGGCCGAGGCCCCTGCATGAAAAGTACAGCGTGAAAGCAACCCTTTCTTCCCCACACCCAGAGAGG
TGAGGCCCGCGTGGACACAGACCAGGGCGCCTCGGTCCCTAGCACGTGAGCTCCAAAAAGCACGAACATGATCCCCTCCCTAACCCCCTC
CTCCCAAAAAGCAGCCAGGAGCACTTTCTTAGAGTTTAAATTATTTTCTTGGGGGCCTGAGGATAGAGAGAGGCAAGGCTAGCCTCCAGA
GCCGATTTATTTGAGAGAGAAACTCTATTTGGATCTCCAGGACGGTTTATACGATCTTTTTCTATCAGCTCCTCTTCCGCCAGAGGCCAC
TGCACCTGGGCTAGGGGTCCACAGGCCCCTCCACCTTCCAGCTAACCAGGCCAGGCCGGGGCGGTGGAGCCACCACACAGCCGACTCTCT
CCTCCTCCTCCCGGCACGACCTGGCCCTGACCAGCAGCCTCGGCCTCTTCTGGGTTCCAGGAGGGGCTCCCGAAGCCCTCAGGACAGGGC
TGGAGGAGAACAGCCTTCATCTCCTCCTCTGGTTTTTTTTTCCTTTGCAAGTCTCCCAGCCCATCTCTCCGAGCAGCGGCCACCAGACCC
CCTCACCATGCTCCCCGGGGAGCACTGCACCCCGCGAACCCCACTGGACGCTGGTTCTCTAAAGGCAATAAGGGGCGGCCATGCCGGTGT
GGTACCACGCTGTTCCTCCAGGAAACCGTTTCTTTTTTTCCTTCTTTAAAAGCAAACAGAAAAAGATATATATATATATATATATATATT
TATTTTTTCATGTAGAGTTGGCGCCAGAACAAGCCTGTATGGCCACAGTCTGTGGATTCATCCCCCCAACCTCAAGCTGAGGACCAAGGC
GTGTCCCCTGTGGGCTGGGGGTCAGTGGGAGGACCAGAGGGATGAAGTCAGGGCAGGCCGGTGCCCTTTTTGGGAGGCACCAGGCGGGGA
GGAGTTGGCGGAGCAGGTCTGGCTGTGAGCCAGCACCAGGCAACCCGGCCCTTGTCCAGGGACCTCTGCTGCCTTCTCTCTGGGGTCAGG
AACCTCAGAGGAGGGGGCTCTGGGGACTGCATAGGACGCAGGCACTCGGAGGTGCCGGTGTGGATGGGTGGGGGTGAGAGAAGAGGGTTC
TTATCGCGTCTCCTGTGATCAGCCTCTGGCCCCCTGGAGGAGGAAACCTCAGCGCTGCCCCTGCCCCCACCCTCACCCCCAACACCAAGA
GTGAGGTGGGCGTGCCCCAGGCAGCGTCCTCAGCCCTGGCCAGCTACTGTGATGCCATCTTCTCCCCCATCCCCTTCTCTGGGGGGCCCA
CCCGTCCCCCACCCCCACCCCTTAGACCCTCATCGGGTCCCTTTTTTTTTTTTTTTTTCAGTTGTCTCCTCCCATCTTCAGATCATTCGA
ATCATTTTGGGGACTTAATCATGTACATGGACAAGTGTAAATTATGATTTTTGGTTTTGTTTTCTGTTATTTTTTAAGGATTTCTGCAAA
AACAGATCTATTTAATTTGAGGTTGATGTTCTATCCAATGGCCGAAGATAGCAGCAGGTTTTTTTTTTCATATGTTGATTTGTTTCATTT
GGATTTTTTTTTTATTATTCTTTATTGTCTTTTTTTTTTCCCCATCCCTGTCTTGAGATTTTCTGGCATGTTTCTGGAGGTTTCAAAGGA

>85852_85852_2_SPINT2-SIPA1L3_SPINT2_chr19_38755638_ENST00000454580_SIPA1L3_chr19_38597177_ENST00000222345_length(amino acids)=1148AA_BP=43
MRVSAELAMAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHADSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIV
TIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAENAAHKSDKF
HTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLR
TKEVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDY
GFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQ
WSGPASHNSLPASKWATPTTPGHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFPETPYTVSPAGADRVPPYRQPSGSFSTPGSATYVRYK
PSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQKPEPLWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSKGEP
QYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPLSKGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGR
SHHADRRREVSPAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSRDPPRQPSDMGSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSASVPK
SFFSKQPVRNKHPTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQ
SPQKGLQRTLSDESLCSGRREPSFASPAGLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASELSL
ADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLD

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Fusion Gene PPI Analysis for SPINT2-SIPA1L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPINT2-SIPA1L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPINT2-SIPA1L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource