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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPINT2-TYROBP (FusionGDB2 ID:85854)

Fusion Gene Summary for SPINT2-TYROBP

check button Fusion gene summary
Fusion gene informationFusion gene name: SPINT2-TYROBP
Fusion gene ID: 85854
HgeneTgene
Gene symbol

SPINT2

TYROBP

Gene ID

10653

7305

Gene nameserine peptidase inhibitor, Kunitz type 2transmembrane immune signaling adaptor TYROBP
SynonymsDIAR3|HAI-2|HAI2|Kop|PBDAP12|KARAP|PLOSL|PLOSL1
Cytomap

19q13.2

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionkunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183TYRO protein tyrosine kinase-binding proteinDNAX adaptor protein 12DNAX-activation protein 12KAR-associated proteinTYRO protein tyrosine kinase binding proteinkiller-activating receptor-associated proteinpolycystic lipomembranous osteodysplasia with
Modification date2020031520200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000301244, ENST00000454580, 
ENST00000587090, 		ENST00000262629, 
ENST00000424586, ENST00000544690, 
ENST00000585901, ENST00000589517, 
Fusion gene scores* DoF score16 X 8 X 9=11525 X 6 X 4=120
# samples 217
** MAII scorelog2(21/1152*10)=-2.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPINT2 [Title/Abstract] AND TYROBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPINT2(38755638)-TYROBP(36398482), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPINT2

GO:0022408

negative regulation of cell-cell adhesion

19592578

HgeneSPINT2

GO:2000146

negative regulation of cell motility

19592578

TgeneTYROBP

GO:0002274

myeloid leukocyte activation

10604985

TgeneTYROBP

GO:0050821

protein stabilization

25957402


check buttonFusion gene breakpoints across SPINT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TYROBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-57-1994-01ASPINT2chr19

38755638

+TYROBPchr19

36398482

-
ChimerDB4OVTCGA-57-1994-01ASPINT2chr19

38755638

+TYROBPchr19

36399209

-
ChimerDB4OVTCGA-57-1994SPINT2chr19

38755638

+TYROBPchr19

36399211

-


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Fusion Gene ORF analysis for SPINT2-TYROBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000301244ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000301244ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000301244ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000301244ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000301244ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000301244ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000301244ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000301244ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000301244ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000301244ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000454580ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000454580ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000454580ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000454580ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000454580ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000454580ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000454580ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000454580ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36399211

-
5CDS-intronENST00000454580ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36399209

-
5CDS-intronENST00000454580ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36399211

-
In-frameENST00000301244ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000301244ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000301244ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000301244ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000301244ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000454580ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000454580ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000454580ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000454580ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36398482

-
In-frameENST00000454580ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36398482

-
intron-3CDSENST00000587090ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36398482

-
intron-3CDSENST00000587090ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36398482

-
intron-3CDSENST00000587090ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36398482

-
intron-3CDSENST00000587090ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36398482

-
intron-3CDSENST00000587090ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36398482

-
intron-intronENST00000587090ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36399209

-
intron-intronENST00000587090ENST00000262629SPINT2chr19

38755638

+TYROBPchr19

36399211

-
intron-intronENST00000587090ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36399209

-
intron-intronENST00000587090ENST00000424586SPINT2chr19

38755638

+TYROBPchr19

36399211

-
intron-intronENST00000587090ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36399209

-
intron-intronENST00000587090ENST00000544690SPINT2chr19

38755638

+TYROBPchr19

36399211

-
intron-intronENST00000587090ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36399209

-
intron-intronENST00000587090ENST00000585901SPINT2chr19

38755638

+TYROBPchr19

36399211

-
intron-intronENST00000587090ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36399209

-
intron-intronENST00000587090ENST00000589517SPINT2chr19

38755638

+TYROBPchr19

36399211

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000301244SPINT2chr1938755638+ENST00000424586TYROBPchr1936398482-9545418300277
ENST00000301244SPINT2chr1938755638+ENST00000585901TYROBPchr1936398482-1048541411881156
ENST00000301244SPINT2chr1938755638+ENST00000544690TYROBPchr1936398482-9555418330278
ENST00000301244SPINT2chr1938755638+ENST00000262629TYROBPchr1936398482-9485418330278
ENST00000301244SPINT2chr1938755638+ENST00000589517TYROBPchr1936398482-7955417670256
ENST00000454580SPINT2chr1938755638+ENST00000424586TYROBPchr1936398482-8364237122237
ENST00000454580SPINT2chr1938755638+ENST00000585901TYROBPchr1936398482-930423293763156
ENST00000454580SPINT2chr1938755638+ENST00000544690TYROBPchr1936398482-8374237152238
ENST00000454580SPINT2chr1938755638+ENST00000262629TYROBPchr1936398482-8304237152238
ENST00000454580SPINT2chr1938755638+ENST00000589517TYROBPchr1936398482-6774236492216

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000301244ENST00000424586SPINT2chr1938755638+TYROBPchr1936398482-0.114161730.8858382
ENST00000301244ENST00000585901SPINT2chr1938755638+TYROBPchr1936398482-0.208315850.7916842
ENST00000301244ENST00000544690SPINT2chr1938755638+TYROBPchr1936398482-0.093468380.9065317
ENST00000301244ENST00000262629SPINT2chr1938755638+TYROBPchr1936398482-0.0953334640.90466654
ENST00000301244ENST00000589517SPINT2chr1938755638+TYROBPchr1936398482-0.0816135260.91838646
ENST00000454580ENST00000424586SPINT2chr1938755638+TYROBPchr1936398482-0.061796540.9382034
ENST00000454580ENST00000585901SPINT2chr1938755638+TYROBPchr1936398482-0.153067450.8469326
ENST00000454580ENST00000544690SPINT2chr1938755638+TYROBPchr1936398482-0.0588516670.9411484
ENST00000454580ENST00000262629SPINT2chr1938755638+TYROBPchr1936398482-0.06407960.9359204
ENST00000454580ENST00000589517SPINT2chr1938755638+TYROBPchr1936398482-0.04309090.9569091

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Fusion Genomic Features for SPINT2-TYROBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPINT2-TYROBP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:38755638/chr19:36398482)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTYROBPchr19:38755638chr19:36398482ENST000002626291580_10831114.0DomainNote=ITAM
TgeneTYROBPchr19:38755638chr19:36398482ENST000005446900480_10820103.0DomainNote=ITAM
TgeneTYROBPchr19:38755638chr19:36398482ENST000005895171580_10831113.0DomainNote=ITAM
TgeneTYROBPchr19:38755638chr19:36398482ENST000002626291562_11331114.0Topological domainCytoplasmic
TgeneTYROBPchr19:38755638chr19:36398482ENST000005446900422_4020103.0Topological domainExtracellular
TgeneTYROBPchr19:38755638chr19:36398482ENST000005446900462_11320103.0Topological domainCytoplasmic
TgeneTYROBPchr19:38755638chr19:36398482ENST000005895171562_11331113.0Topological domainCytoplasmic
TgeneTYROBPchr19:38755638chr19:36398482ENST000002626291541_6131114.0TransmembraneHelical
TgeneTYROBPchr19:38755638chr19:36398482ENST000005446900441_6120103.0TransmembraneHelical
TgeneTYROBPchr19:38755638chr19:36398482ENST000005895171541_6131113.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPINT2chr19:38755638chr19:36398482ENST00000301244+17219_25235253.0Topological domainCytoplasmic
HgeneSPINT2chr19:38755638chr19:36398482ENST00000301244+1728_19735253.0Topological domainExtracellular
HgeneSPINT2chr19:38755638chr19:36398482ENST00000454580+16219_25235196.0Topological domainCytoplasmic
HgeneSPINT2chr19:38755638chr19:36398482ENST00000454580+1628_19735196.0Topological domainExtracellular
HgeneSPINT2chr19:38755638chr19:36398482ENST00000301244+17198_21835253.0TransmembraneHelical
HgeneSPINT2chr19:38755638chr19:36398482ENST00000454580+16198_21835196.0TransmembraneHelical
TgeneTYROBPchr19:38755638chr19:36398482ENST000002626291522_4031114.0Topological domainExtracellular
TgeneTYROBPchr19:38755638chr19:36398482ENST000005895171522_4031113.0Topological domainExtracellular


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Fusion Gene Sequence for SPINT2-TYROBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85854_85854_1_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000262629_length(transcript)=948nt_BP=541nt
GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT
CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC
GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC
GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT
TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC
GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC
GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG
TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTAT
CAGGAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGC
AACATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCC

>85854_85854_1_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000262629_length(amino acids)=278AA_BP=0
MAGSRYHVADCHDSGSFVIRPLCVEVAVDIRPLTLELLIRRLGLSDTLFPGRCLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHAR
AHRRATAIVDAAFSVGRQDPREEQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGA
KAPGSRLSGPSVWGRPAFSARDAWVCSSLAPSPPATLNGPQRVQSRATPPNARRSPEPMANAYWKRLPKVAGQAGGGAHLARQGELGAGA

--------------------------------------------------------------
>85854_85854_2_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000424586_length(transcript)=954nt_BP=541nt
GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT
CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC
GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC
GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT
TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC
GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC
GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG
TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAG
GAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAAC
ATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGA

>85854_85854_2_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000424586_length(amino acids)=277AA_BP=0
MAGSRYHVADCHDSGSFVIRPLCVEVAVDIRPLTLELLIRRLGLSDTLFPGRLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHARA
HRRATAIVDAAFSVGRQDPREEQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGAK
APGSRLSGPSVWGRPAFSARDAWVCSSLAPSPPATLNGPQRVQSRATPPNARRSPEPMANAYWKRLPKVAGQAGGGAHLARQGELGAGAK

--------------------------------------------------------------
>85854_85854_3_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000544690_length(transcript)=955nt_BP=541nt
GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT
CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC
GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC
GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT
TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC
GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC
GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG
TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTAT
CAGGAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGC
AACATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCC

>85854_85854_3_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000544690_length(amino acids)=278AA_BP=0
MAGSRYHVADCHDSGSFVIRPLCVEVAVDIRPLTLELLIRRLGLSDTLFPGRCLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHAR
AHRRATAIVDAAFSVGRQDPREEQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGA
KAPGSRLSGPSVWGRPAFSARDAWVCSSLAPSPPATLNGPQRVQSRATPPNARRSPEPMANAYWKRLPKVAGQAGGGAHLARQGELGAGA

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>85854_85854_4_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000585901_length(transcript)=1048nt_BP=541nt
GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT
CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC
GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC
GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT
TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC
GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC
GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG
TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGGGATGGTAATGGAGGTGCTGATTTGGAATGACAAAACACCCTCA
ACTCACCACTCTGCCTGTCTCTGCACCCCACAACACCCCTCACCTCCAGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCT
TATCAGGAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTC
AGCAACATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCAT

>85854_85854_4_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000585901_length(amino acids)=156AA_BP=43
MRVSAELAMAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEGM

--------------------------------------------------------------
>85854_85854_5_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000589517_length(transcript)=795nt_BP=541nt
GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT
CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC
GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC
GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT
TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC
GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC
GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG
TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAG

>85854_85854_5_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000301244_TYROBP_chr19_36398482_ENST00000589517_length(amino acids)=256AA_BP=1
MCVEVAVDIRPLTLELLIRRLGLSDTLFPGRLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHARAHRRATAIVDAAFSVGRQDPRE
EQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGAKAPGSRLSGPSVWGRPAFSARD

--------------------------------------------------------------
>85854_85854_6_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000262629_length(transcript)=830nt_BP=423nt
ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG
AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA
CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG
ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG
CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG
GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG
GGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATG
TCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATTCCT
GAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATACTC

>85854_85854_6_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000262629_length(amino acids)=238AA_BP=0
MAGSRYHVADCHDSGSFVIRPLCVEVAVDIRPLTLELLIRRLGLSDTLFPGRCLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHAR
AHRRATAIVDAAFSVGRQDPREEQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGA

--------------------------------------------------------------
>85854_85854_7_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000424586_length(transcript)=836nt_BP=423nt
ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG
AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA
CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG
ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG
CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG
GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG
GGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATGTCT
ACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATTCCTGAA
GCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATACTCTCC

>85854_85854_7_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000424586_length(amino acids)=237AA_BP=0
MAGSRYHVADCHDSGSFVIRPLCVEVAVDIRPLTLELLIRRLGLSDTLFPGRLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHARA
HRRATAIVDAAFSVGRQDPREEQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGAK

--------------------------------------------------------------
>85854_85854_8_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000544690_length(transcript)=837nt_BP=423nt
ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG
AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA
CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG
ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG
CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG
GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG
GGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATG
TCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATTCCT
GAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATACTC

>85854_85854_8_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000544690_length(amino acids)=238AA_BP=0
MAGSRYHVADCHDSGSFVIRPLCVEVAVDIRPLTLELLIRRLGLSDTLFPGRCLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHAR
AHRRATAIVDAAFSVGRQDPREEQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGA

--------------------------------------------------------------
>85854_85854_9_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000585901_length(transcript)=930nt_BP=423nt
ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG
AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA
CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG
ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG
CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG
GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG
GGCGAGGGGCTGCGGAGGGGATGGTAATGGAGGTGCTGATTTGGAATGACAAAACACCCTCAACTCACCACTCTGCCTGTCTCTGCACCC
CACAACACCCCTCACCTCCAGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGG
ATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATT
CCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATA

>85854_85854_9_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000585901_length(amino acids)=156AA_BP=43
MRVSAELAMAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEGM

--------------------------------------------------------------
>85854_85854_10_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000589517_length(transcript)=677nt_BP=423nt
ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG
AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA
CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG
ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG
CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG
GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG
GGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATGTCT

>85854_85854_10_SPINT2-TYROBP_SPINT2_chr19_38755638_ENST00000454580_TYROBP_chr19_36398482_ENST00000589517_length(amino acids)=216AA_BP=1
MCVEVAVDIRPLTLELLIRRLGLSDTLFPGRLRSPSPPRDQPAQEVHGQGNEHCQHQVSHHDPCQHARAHRRATAIVDAAFSVGRQDPRE
EQRSQQGEKRPAPPQPAQLRHGQLSRDAQATPPAVGVSRSGAGSPSTRTRNGAPRVQVPTLREGPPGAKAPGSRLSGPSVWGRPAFSARD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPINT2-TYROBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPINT2-TYROBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPINT2-TYROBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource