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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPOCK1-WDR19 (FusionGDB2 ID:85895)

Fusion Gene Summary for SPOCK1-WDR19

check button Fusion gene summary
Fusion gene informationFusion gene name: SPOCK1-WDR19
Fusion gene ID: 85895
HgeneTgene
Gene symbol

SPOCK1

WDR19

Gene ID

6695

57728

Gene nameSPARC (osteonectin), cwcv and kazal like domains proteoglycan 1WD repeat domain 19
SynonymsSPOCK|TESTICAN|TIC1ATD5|CED4|DYF-2|FAP66|IFT144|NPHP13|ORF26|Oseg6|PWDMP|SRTD5
Cytomap

5q31.2

4p14

Type of geneprotein-codingprotein-coding
Descriptiontestican-1SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1WD repeat-containing protein 19WD repeat membrane protein PWDMPintraflagellar transport 144 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282223, ENST00000394945, 
ENST00000509978, 
ENST00000506503, 
ENST00000515631, ENST00000288634, 
ENST00000399820, 
Fusion gene scores* DoF score11 X 9 X 5=4957 X 8 X 7=392
# samples 118
** MAII scorelog2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/392*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPOCK1 [Title/Abstract] AND WDR19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPOCK1(136834062)-WDR19(39229830), # samples:1
Anticipated loss of major functional domain due to fusion event.SPOCK1-WDR19 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPOCK1

GO:0010812

negative regulation of cell-substrate adhesion

12853036

HgeneSPOCK1

GO:0010951

negative regulation of endopeptidase activity

14511383

HgeneSPOCK1

GO:0010977

negative regulation of neuron projection development

12853036


check buttonFusion gene breakpoints across SPOCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WDR19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8080-01ASPOCK1chr5

136834062

-WDR19chr4

39229830

+


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Fusion Gene ORF analysis for SPOCK1-WDR19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000282223ENST00000506503SPOCK1chr5

136834062

-WDR19chr4

39229830

+
5CDS-intronENST00000282223ENST00000515631SPOCK1chr5

136834062

-WDR19chr4

39229830

+
5CDS-intronENST00000394945ENST00000506503SPOCK1chr5

136834062

-WDR19chr4

39229830

+
5CDS-intronENST00000394945ENST00000515631SPOCK1chr5

136834062

-WDR19chr4

39229830

+
Frame-shiftENST00000394945ENST00000288634SPOCK1chr5

136834062

-WDR19chr4

39229830

+
Frame-shiftENST00000394945ENST00000399820SPOCK1chr5

136834062

-WDR19chr4

39229830

+
In-frameENST00000282223ENST00000288634SPOCK1chr5

136834062

-WDR19chr4

39229830

+
In-frameENST00000282223ENST00000399820SPOCK1chr5

136834062

-WDR19chr4

39229830

+
intron-3CDSENST00000509978ENST00000288634SPOCK1chr5

136834062

-WDR19chr4

39229830

+
intron-3CDSENST00000509978ENST00000399820SPOCK1chr5

136834062

-WDR19chr4

39229830

+
intron-intronENST00000509978ENST00000506503SPOCK1chr5

136834062

-WDR19chr4

39229830

+
intron-intronENST00000509978ENST00000515631SPOCK1chr5

136834062

-WDR19chr4

39229830

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000282223SPOCK1chr5136834062-ENST00000399820WDR19chr439229830+292318602585861
ENST00000282223SPOCK1chr5136834062-ENST00000288634WDR19chr439229830+289318602585861

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282223ENST00000399820SPOCK1chr5136834062-WDR19chr439229830+0.001034090.99896586
ENST00000282223ENST00000288634SPOCK1chr5136834062-WDR19chr439229830+0.0011097740.9988902

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Fusion Genomic Features for SPOCK1-WDR19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPOCK1chr5136834061-WDR19chr439229829+8.12E-070.99999917
SPOCK1chr5136834061-WDR19chr439229829+8.12E-070.99999917

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPOCK1-WDR19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:136834062/chr4:39229830)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR19chr5:136834062chr4:39229830ENST0000039982014371020_10535431397.6666666666667RepeatNote=TPR 6
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437736_7695431397.6666666666667RepeatNote=TPR 1
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437775_8085431397.6666666666667RepeatNote=TPR 2
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437840_8735431397.6666666666667RepeatNote=TPR 3
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437895_9285431397.6666666666667RepeatNote=TPR 4
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437951_9845431397.6666666666667RepeatNote=TPR 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPOCK1chr5:136834062chr4:39229830ENST00000282223-110130_18262440.0DomainKazal-like
HgeneSPOCK1chr5:136834062chr4:39229830ENST00000282223-110310_37662440.0DomainThyroglobulin type-1
HgeneSPOCK1chr5:136834062chr4:39229830ENST00000394945-211130_18262440.0DomainKazal-like
HgeneSPOCK1chr5:136834062chr4:39229830ENST00000394945-211310_37662440.0DomainThyroglobulin type-1
TgeneWDR19chr5:136834062chr4:39229830ENST00000399820143711_515431397.6666666666667RepeatNote=WD 1
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437137_1755431397.6666666666667RepeatNote=WD 4
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437273_3115431397.6666666666667RepeatNote=WD 5
TgeneWDR19chr5:136834062chr4:39229830ENST000003998201437317_3565431397.6666666666667RepeatNote=WD 6
TgeneWDR19chr5:136834062chr4:39229830ENST00000399820143752_925431397.6666666666667RepeatNote=WD 2
TgeneWDR19chr5:136834062chr4:39229830ENST00000399820143795_1345431397.6666666666667RepeatNote=WD 3


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Fusion Gene Sequence for SPOCK1-WDR19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85895_85895_1_SPOCK1-WDR19_SPOCK1_chr5_136834062_ENST00000282223_WDR19_chr4_39229830_ENST00000288634_length(transcript)=2893nt_BP=186nt
ATGCCGGCGATCGCGGTGTTGGCGGCGGCCGCCGCGGCGTGGTGCTTCCTCCAAGTCGAGAGCCGGCACCTGGACGCGCTCGCCGGAGGC
GCGGGCCCCAACCACGGCAATTTCCTAGACAATGACCAGTGGCTGAGCACCGTCTCCCAGTACGACCGGGACAAGTACTGGAACCGCTTT
CGAGACGTCAATGACGCTACCTATGAGATTCCAGATTTTTCACCAACCATTAAAGGTGTTCTTTGGGAAAACTGGCCAATGGATAAAGGT
GTATTTATTGCTTATGATGATGATAAGGTGTACACTTATGTCTTTCACAAGGACACTATACAAGGAGCCAAGGTTATTTTGGCTGGTAGC
ACCAAAGTTCCTTTTGCTCATAAACCTTTGCTGCTATATAATGGAGAGCTGACCTGCCAAACACAGAGTGGAAAAGTAAACAACATCTAC
CTTAGCACCCATGGCTTTCTCAGCAACTTAAAAGATACGGGGCCTGACGAACTGAGACCAATGCTGGCACAGAATTTAATGCTAAAGAGG
TTTTCTGATGCTTGGGAAATGTGCAGGATTCTGAATGATGAGGCTGCCTGGAATGAGTTGGCCAGAGCTTGTCTACATCACATGGAAGTG
GAGTTTGCAATCCGTGTTTATCGGAGAATTGGAAATGTTGGCATAGTGATGTCCTTGGAACAAATAAAGGGAATAGAGGACTACAATCTT
TTGGCAGGACACCTTGCCATGTTTACCAACGATTATAACCTGGCTCAGGACTTGTACCTTGCATCCAGCTGTCCTATTGCTGCCCTGGAG
ATGAGAAGGGATTTACAGCATTGGGACAGTGCTCTACAACTGGCAAAGCATTTGGCCCCAGACCAGATACCTTTTATATCAAAAGAATAT
GCTATTCAGCTTGAATTCGCGGGTGATTATGTAAATGCTTTGGCTCATTATGAGAAAGGAATAACAGGTGATAATAAGGAACATGATGAA
GCTTGTCTGGCTGGAGTGGCCCAGATGTCCATAAGAATGGGAGACATACGTCGAGGGGTTAACCAAGCCCTCAAGCATCCCAGCAGGGTC
CTTAAAAGAGACTGTGGAGCCATATTGGAGAATATGAAGCAATTTTCAGAAGCGGCCCAACTGTATGAAAAAGGTCTCTACTACGATAAA
GCAGCATCTGTTTACATCCGCTCTAAGAATTGGGCAAAAGTTGGTGATCTTCTGCCCCACGTTTCTTCTCCTAAGATCCATTTGCAGTAT
GCCAAAGCCAAGGAAGCAGATGGAAGATACAAAGAAGCTGTTGTAGCTTATGAAAATGCAAAACAGTGGCAAAGTGTAATCCGCATCTAT
CTGGATCACCTCAATAATCCTGAAAAAGCTGTCAATATTGTTAGAGAGACCCAGTCTCTGGATGGAGCCAAAATGGTAGCCAGGTTTTTT
CTACAGCTTGGTGACTATGGGTCTGCCATCCAGTTTCTTGTCATGTCCAAATGCAACAATGAAGCTTTCACACTGGCTCAGCAACACAAC
AAAATGGAAATCTATGCAGATATTATTGGTTCTGAAGACACTACTAATGAAGACTATCAAAGCATTGCCTTATACTTTGAAGGAGAAAAG
AGATATCTTCAGGCTGGAAAATTCTTCTTGCTGTGTGGCCAATATTCACGAGCACTTAAACACTTCCTGAAATGCCCAAGCTCGGAAGAT
AATGTGGCAATAGAAATGGCAATTGAAACTGTTGGTCAGGCCAAAGATGAACTGCTGACCAATCAGCTGATAGACCATCTCCTGGGGGAG
AACGATGGCATGCCTAAGGATGCCAAGTACCTGTTCCGCTTGTACATGGCTCTGAAGCAATACCGAGAAGCTGCCCAGACTGCCATCATC
ATTGCCAGAGAAGAGCAGTCTGCAGGCAACTACCGGAATGCACACGATGTTCTCTTCAGTATGTATGCAGAACTGAAATCCCAGAAGATC
AAAATTCCCTCCGAGATGGCCACCAACCTCATGATTCTGCACAGCTATATACTAGTAAAGATTCATGTTAAAAATGGAGATCACATGAAA
GGGGCTCGCATGCTCATTCGGGTGGCCAACAACATCAGCAAATTTCCATCACACATTGTACCCATCCTGACGTCAACTGTGATTGAGTGT
CACAGGGCAGGCCTGAAGAACTCTGCTTTCAGCTTCGCAGCTATGTTGATGAGGCCTGAATACCGCAGCAAAATAGATGCCAAATACAAA
AAGAAGATCGAGGGAATGGTCAGGAGACCCGATATATCTGAGATAGAAGAGGCCACGACTCCATGTCCATTCTGCAAATTTCTTCTCCCA
GAGTGTGAACTCCTCTGTCCTGGATGTAAAAACAGTATCCCATATTGCATTGCAACAGGTCGACACATGTTGAAAGATGACTGGACGGTG
TGTCCACATTGTGACTTCCCTGCTCTATACTCAGAATTGAAGATCATGCTAAACACTGAAAGCACATGTCCTATGTGTTCAGAAAGATTA
AACGCTGCTCAGCTGAAAAAGATTTCAGACTGTACCCAGTACCTGCGAACGGAGGAGGAACTGTGATTGGCACGTGCAGATACAATGCTC
CTGAGAAGACAGCATTTTCCACAGGAGGCTGTTTCCTCCCCTGGTGGATTTAAGAGACGGTCCTTTCTGGATACAGAGAAATGAAACAAC
GGTGACCTCTCCAGGTCGGCACTTTCCACTTCTGTACGGTGGCAAAACGATGACATGTAACCTTGCTGTTTATTGTACTTTGTATATTAT
TTCCTCTTCAAAGTCTTTCTTACACACTCTATCCTCTGCACTGTTAATAGTAACCTATGACATAATTGTAAATATTCAGCTTTTTGCTAA

>85895_85895_1_SPOCK1-WDR19_SPOCK1_chr5_136834062_ENST00000282223_WDR19_chr4_39229830_ENST00000288634_length(amino acids)=861AA_BP=62
MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDKYWNRFRDVNDATYEIPDFSPTIKGVLWENWPMDKG
VFIAYDDDKVYTYVFHKDTIQGAKVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLKR
FSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALE
MRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRV
LKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIY
LDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGEK
RYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLYMALKQYREAAQTAII
IAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIEC
HRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLLPECELLCPGCKNSIPYCIATGRHMLKDDWTV

--------------------------------------------------------------
>85895_85895_2_SPOCK1-WDR19_SPOCK1_chr5_136834062_ENST00000282223_WDR19_chr4_39229830_ENST00000399820_length(transcript)=2923nt_BP=186nt
ATGCCGGCGATCGCGGTGTTGGCGGCGGCCGCCGCGGCGTGGTGCTTCCTCCAAGTCGAGAGCCGGCACCTGGACGCGCTCGCCGGAGGC
GCGGGCCCCAACCACGGCAATTTCCTAGACAATGACCAGTGGCTGAGCACCGTCTCCCAGTACGACCGGGACAAGTACTGGAACCGCTTT
CGAGACGTCAATGACGCTACCTATGAGATTCCAGATTTTTCACCAACCATTAAAGGTGTTCTTTGGGAAAACTGGCCAATGGATAAAGGT
GTATTTATTGCTTATGATGATGATAAGGTGTACACTTATGTCTTTCACAAGGACACTATACAAGGAGCCAAGGTTATTTTGGCTGGTAGC
ACCAAAGTTCCTTTTGCTCATAAACCTTTGCTGCTATATAATGGAGAGCTGACCTGCCAAACACAGAGTGGAAAAGTAAACAACATCTAC
CTTAGCACCCATGGCTTTCTCAGCAACTTAAAAGATACGGGGCCTGACGAACTGAGACCAATGCTGGCACAGAATTTAATGCTAAAGAGG
TTTTCTGATGCTTGGGAAATGTGCAGGATTCTGAATGATGAGGCTGCCTGGAATGAGTTGGCCAGAGCTTGTCTACATCACATGGAAGTG
GAGTTTGCAATCCGTGTTTATCGGAGAATTGGAAATGTTGGCATAGTGATGTCCTTGGAACAAATAAAGGGAATAGAGGACTACAATCTT
TTGGCAGGACACCTTGCCATGTTTACCAACGATTATAACCTGGCTCAGGACTTGTACCTTGCATCCAGCTGTCCTATTGCTGCCCTGGAG
ATGAGAAGGGATTTACAGCATTGGGACAGTGCTCTACAACTGGCAAAGCATTTGGCCCCAGACCAGATACCTTTTATATCAAAAGAATAT
GCTATTCAGCTTGAATTCGCGGGTGATTATGTAAATGCTTTGGCTCATTATGAGAAAGGAATAACAGGTGATAATAAGGAACATGATGAA
GCTTGTCTGGCTGGAGTGGCCCAGATGTCCATAAGAATGGGAGACATACGTCGAGGGGTTAACCAAGCCCTCAAGCATCCCAGCAGGGTC
CTTAAAAGAGACTGTGGAGCCATATTGGAGAATATGAAGCAATTTTCAGAAGCGGCCCAACTGTATGAAAAAGGTCTCTACTACGATAAA
GCAGCATCTGTTTACATCCGCTCTAAGAATTGGGCAAAAGTTGGTGATCTTCTGCCCCACGTTTCTTCTCCTAAGATCCATTTGCAGTAT
GCCAAAGCCAAGGAAGCAGATGGAAGATACAAAGAAGCTGTTGTAGCTTATGAAAATGCAAAACAGTGGCAAAGTGTAATCCGCATCTAT
CTGGATCACCTCAATAATCCTGAAAAAGCTGTCAATATTGTTAGAGAGACCCAGTCTCTGGATGGAGCCAAAATGGTAGCCAGGTTTTTT
CTACAGCTTGGTGACTATGGGTCTGCCATCCAGTTTCTTGTCATGTCCAAATGCAACAATGAAGCTTTCACACTGGCTCAGCAACACAAC
AAAATGGAAATCTATGCAGATATTATTGGTTCTGAAGACACTACTAATGAAGACTATCAAAGCATTGCCTTATACTTTGAAGGAGAAAAG
AGATATCTTCAGGCTGGAAAATTCTTCTTGCTGTGTGGCCAATATTCACGAGCACTTAAACACTTCCTGAAATGCCCAAGCTCGGAAGAT
AATGTGGCAATAGAAATGGCAATTGAAACTGTTGGTCAGGCCAAAGATGAACTGCTGACCAATCAGCTGATAGACCATCTCCTGGGGGAG
AACGATGGCATGCCTAAGGATGCCAAGTACCTGTTCCGCTTGTACATGGCTCTGAAGCAATACCGAGAAGCTGCCCAGACTGCCATCATC
ATTGCCAGAGAAGAGCAGTCTGCAGGCAACTACCGGAATGCACACGATGTTCTCTTCAGTATGTATGCAGAACTGAAATCCCAGAAGATC
AAAATTCCCTCCGAGATGGCCACCAACCTCATGATTCTGCACAGCTATATACTAGTAAAGATTCATGTTAAAAATGGAGATCACATGAAA
GGGGCTCGCATGCTCATTCGGGTGGCCAACAACATCAGCAAATTTCCATCACACATTGTACCCATCCTGACGTCAACTGTGATTGAGTGT
CACAGGGCAGGCCTGAAGAACTCTGCTTTCAGCTTCGCAGCTATGTTGATGAGGCCTGAATACCGCAGCAAAATAGATGCCAAATACAAA
AAGAAGATCGAGGGAATGGTCAGGAGACCCGATATATCTGAGATAGAAGAGGCCACGACTCCATGTCCATTCTGCAAATTTCTTCTCCCA
GAGTGTGAACTCCTCTGTCCTGGATGTAAAAACAGTATCCCATATTGCATTGCAACAGGTCGACACATGTTGAAAGATGACTGGACGGTG
TGTCCACATTGTGACTTCCCTGCTCTATACTCAGAATTGAAGATCATGCTAAACACTGAAAGCACATGTCCTATGTGTTCAGAAAGATTA
AACGCTGCTCAGCTGAAAAAGATTTCAGACTGTACCCAGTACCTGCGAACGGAGGAGGAACTGTGATTGGCACGTGCAGATACAATGCTC
CTGAGAAGACAGCATTTTCCACAGGAGGCTGTTTCCTCCCCTGGTGGATTTAAGAGACGGTCCTTTCTGGATACAGAGAAATGAAACAAC
GGTGACCTCTCCAGGTCGGCACTTTCCACTTCTGTACGGTGGCAAAACGATGACATGTAACCTTGCTGTTTATTGTACTTTGTATATTAT
TTCCTCTTCAAAGTCTTTCTTACACACTCTATCCTCTGCACTGTTAATAGTAACCTATGACATAATTGTAAATATTCAGCTTTTTGCTAA

>85895_85895_2_SPOCK1-WDR19_SPOCK1_chr5_136834062_ENST00000282223_WDR19_chr4_39229830_ENST00000399820_length(amino acids)=861AA_BP=62
MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDKYWNRFRDVNDATYEIPDFSPTIKGVLWENWPMDKG
VFIAYDDDKVYTYVFHKDTIQGAKVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLKR
FSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALE
MRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRV
LKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIY
LDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGEK
RYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLYMALKQYREAAQTAII
IAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIEC
HRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLLPECELLCPGCKNSIPYCIATGRHMLKDDWTV

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Fusion Gene PPI Analysis for SPOCK1-WDR19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPOCK1-WDR19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPOCK1-WDR19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource