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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPRR3-KRT13 (FusionGDB2 ID:86060)

Fusion Gene Summary for SPRR3-KRT13

check button Fusion gene summary
Fusion gene informationFusion gene name: SPRR3-KRT13
Fusion gene ID: 86060
HgeneTgene
Gene symbol

SPRR3

KRT13

Gene ID

6707

3860

Gene namesmall proline rich protein 3keratin 13
Synonyms-CK13|K13|WSN2
Cytomap

1q21.3

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionsmall proline-rich protein 322 kDa pancornulincornifin betaesophaginkeratin, type I cytoskeletal 13CK-13cytokeratin 13keratin 13, type I
Modification date2020031320200313
UniProtAcc.

P13646

Ensembl transtripts involved in fusion geneENST00000295367, ENST00000331860, 
ENST00000542696, ENST00000495845, 
ENST00000246635, ENST00000336861, 
ENST00000587118, ENST00000587544, 
Fusion gene scores* DoF score5 X 6 X 3=9019 X 33 X 6=3762
# samples 424
** MAII scorelog2(4/90*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3762*10)=-3.97039353791468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPRR3 [Title/Abstract] AND KRT13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPRR3(152976305)-KRT13(39657359), # samples:1
SPRR3(152975574)-KRT13(39661634), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKRT13

GO:0007010

cytoskeleton organization

21371075


check buttonFusion gene breakpoints across SPRR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KRT13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-KH-A6WCSPRR3chr1

152976305

+KRT13chr17

39657359

-
ChimerDB4HNSCTCGA-CV-7103-11ASPRR3chr1

152975574

-KRT13chr17

39661634

-


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Fusion Gene ORF analysis for SPRR3-KRT13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000295367ENST00000246635SPRR3chr1

152976305

+KRT13chr17

39657359

-
3UTR-3UTRENST00000295367ENST00000336861SPRR3chr1

152976305

+KRT13chr17

39657359

-
3UTR-3UTRENST00000331860ENST00000246635SPRR3chr1

152976305

+KRT13chr17

39657359

-
3UTR-3UTRENST00000331860ENST00000336861SPRR3chr1

152976305

+KRT13chr17

39657359

-
3UTR-intronENST00000295367ENST00000587118SPRR3chr1

152976305

+KRT13chr17

39657359

-
3UTR-intronENST00000295367ENST00000587544SPRR3chr1

152976305

+KRT13chr17

39657359

-
3UTR-intronENST00000331860ENST00000587118SPRR3chr1

152976305

+KRT13chr17

39657359

-
3UTR-intronENST00000331860ENST00000587544SPRR3chr1

152976305

+KRT13chr17

39657359

-
5CDS-intronENST00000295367ENST00000587118SPRR3chr1

152975574

-KRT13chr17

39661634

-
5CDS-intronENST00000331860ENST00000587118SPRR3chr1

152975574

-KRT13chr17

39661634

-
5CDS-intronENST00000542696ENST00000587118SPRR3chr1

152975574

-KRT13chr17

39661634

-
Frame-shiftENST00000295367ENST00000246635SPRR3chr1

152975574

-KRT13chr17

39661634

-
Frame-shiftENST00000295367ENST00000336861SPRR3chr1

152975574

-KRT13chr17

39661634

-
Frame-shiftENST00000295367ENST00000587544SPRR3chr1

152975574

-KRT13chr17

39661634

-
Frame-shiftENST00000331860ENST00000246635SPRR3chr1

152975574

-KRT13chr17

39661634

-
Frame-shiftENST00000331860ENST00000336861SPRR3chr1

152975574

-KRT13chr17

39661634

-
Frame-shiftENST00000331860ENST00000587544SPRR3chr1

152975574

-KRT13chr17

39661634

-
In-frameENST00000542696ENST00000246635SPRR3chr1

152975574

-KRT13chr17

39661634

-
In-frameENST00000542696ENST00000336861SPRR3chr1

152975574

-KRT13chr17

39661634

-
In-frameENST00000542696ENST00000587544SPRR3chr1

152975574

-KRT13chr17

39661634

-
intron-3CDSENST00000495845ENST00000246635SPRR3chr1

152975574

-KRT13chr17

39661634

-
intron-3CDSENST00000495845ENST00000336861SPRR3chr1

152975574

-KRT13chr17

39661634

-
intron-3CDSENST00000495845ENST00000587544SPRR3chr1

152975574

-KRT13chr17

39661634

-
intron-3UTRENST00000495845ENST00000246635SPRR3chr1

152976305

+KRT13chr17

39657359

-
intron-3UTRENST00000495845ENST00000336861SPRR3chr1

152976305

+KRT13chr17

39657359

-
intron-3UTRENST00000542696ENST00000246635SPRR3chr1

152976305

+KRT13chr17

39657359

-
intron-3UTRENST00000542696ENST00000336861SPRR3chr1

152976305

+KRT13chr17

39657359

-
intron-intronENST00000495845ENST00000587118SPRR3chr1

152976305

+KRT13chr17

39657359

-
intron-intronENST00000495845ENST00000587118SPRR3chr1

152975574

-KRT13chr17

39661634

-
intron-intronENST00000495845ENST00000587544SPRR3chr1

152976305

+KRT13chr17

39657359

-
intron-intronENST00000542696ENST00000587118SPRR3chr1

152976305

+KRT13chr17

39657359

-
intron-intronENST00000542696ENST00000587544SPRR3chr1

152976305

+KRT13chr17

39657359

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000542696SPRR3chr1152975574-ENST00000336861KRT13chr1739661634-165619810631563166
ENST00000542696SPRR3chr1152975574-ENST00000246635KRT13chr1739661634-168219810891589166
ENST00000542696SPRR3chr1152975574-ENST00000587544KRT13chr1739661634-14231988301330166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000542696ENST00000336861SPRR3chr1152975574-KRT13chr1739661634-0.0069866220.99301344
ENST00000542696ENST00000246635SPRR3chr1152975574-KRT13chr1739661634-0.0074258310.9925742
ENST00000542696ENST00000587544SPRR3chr1152975574-KRT13chr1739661634-0.0037455540.99625444

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Fusion Genomic Features for SPRR3-KRT13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPRR3-KRT13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:152976305/chr17:39657359)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KRT13

P13646

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKRT13chr1:152975574chr17:39661634ENST000002466350813_1020459.0Compositional biasNote=Gly-rich
TgeneKRT13chr1:152975574chr17:39661634ENST000003368610713_1020421.0Compositional biasNote=Gly-rich
TgeneKRT13chr1:152975574chr17:39661634ENST0000024663508104_4160459.0DomainIF rod
TgeneKRT13chr1:152975574chr17:39661634ENST0000033686107104_4160421.0DomainIF rod
TgeneKRT13chr1:152975574chr17:39661634ENST0000024663508104_1390459.0RegionNote=Coil 1A
TgeneKRT13chr1:152975574chr17:39661634ENST0000024663508140_1580459.0RegionNote=Linker 1
TgeneKRT13chr1:152975574chr17:39661634ENST0000024663508159_2500459.0RegionNote=Coil 1B
TgeneKRT13chr1:152975574chr17:39661634ENST00000246635081_1030459.0RegionNote=Head
TgeneKRT13chr1:152975574chr17:39661634ENST0000024663508251_2730459.0RegionNote=Linker 12
TgeneKRT13chr1:152975574chr17:39661634ENST0000024663508274_4120459.0RegionNote=Coil 2
TgeneKRT13chr1:152975574chr17:39661634ENST0000024663508413_4580459.0RegionNote=Tail
TgeneKRT13chr1:152975574chr17:39661634ENST0000033686107104_1390421.0RegionNote=Coil 1A
TgeneKRT13chr1:152975574chr17:39661634ENST0000033686107140_1580421.0RegionNote=Linker 1
TgeneKRT13chr1:152975574chr17:39661634ENST0000033686107159_2500421.0RegionNote=Coil 1B
TgeneKRT13chr1:152975574chr17:39661634ENST00000336861071_1030421.0RegionNote=Head
TgeneKRT13chr1:152975574chr17:39661634ENST0000033686107251_2730421.0RegionNote=Linker 12
TgeneKRT13chr1:152975574chr17:39661634ENST0000033686107274_4120421.0RegionNote=Coil 2
TgeneKRT13chr1:152975574chr17:39661634ENST0000033686107413_4580421.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1243_1540170.0RegionNote=14 X 8 AA approximate tandem repeats
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1343_1540170.0RegionNote=14 X 8 AA approximate tandem repeats
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-12107_1140170.0RepeatNote=9
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-12115_1220170.0RepeatNote=10
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-12123_1300170.0RepeatNote=11
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-12131_1380170.0RepeatNote=12
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-12139_1460170.0RepeatNote=13
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-12147_1540170.0RepeatNote=14
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1243_500170.0RepeatNote=1
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1251_580170.0RepeatNote=2
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1259_660170.0RepeatNote=3
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1267_740170.0RepeatNote=4
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1275_820170.0RepeatNote=5
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1283_900170.0RepeatNote=6
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1291_980170.0RepeatNote=7
HgeneSPRR3chr1:152975574chr17:39661634ENST00000295367-1299_1060170.0RepeatNote=8
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-13107_1140170.0RepeatNote=9
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-13115_1220170.0RepeatNote=10
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-13123_1300170.0RepeatNote=11
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-13131_1380170.0RepeatNote=12
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-13139_1460170.0RepeatNote=13
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-13147_1540170.0RepeatNote=14
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1343_500170.0RepeatNote=1
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1351_580170.0RepeatNote=2
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1359_660170.0RepeatNote=3
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1367_740170.0RepeatNote=4
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1375_820170.0RepeatNote=5
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1383_900170.0RepeatNote=6
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1391_980170.0RepeatNote=7
HgeneSPRR3chr1:152975574chr17:39661634ENST00000331860-1399_1060170.0RepeatNote=8


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Fusion Gene Sequence for SPRR3-KRT13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86060_86060_1_SPRR3-KRT13_SPRR3_chr1_152975574_ENST00000542696_KRT13_chr17_39661634_ENST00000246635_length(transcript)=1682nt_BP=198nt
CCTCCACCTCAGGAAATATTTGTTCCCACAACCAAGGAGCCATGCCACTCAAAGGTTCCACAACCTGGAAACACAAAGATTCCAGAGCCA
GGCTGTACCAAGGTCCCTGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGTTGTACCAAGGTCCCT
GAGCCAGGCTGTACCAAGGAAGCGTCAGCCCCCGTAGCACCTCTGTTACCACGACTTCTAGTGCCTCTGTTACCACCACCTCTAATGCCT
CTGGTCGCCGCACTTCTGATGTCCGTAGGCCTTAAATCTGCCTGGCGTCCCCTCCCTCTGTCTTCAGCACCCAGAGGAGGAGAGAGCCGG
CAGTTCCCTGCAGGAGAGAGGAGGGGCTGCTGGACCCAAGGCTCAGTCCCTCTGCTCTCAGGACCCCCTGTCCTGACTCTCTCCTGATGG
TGGGCCCTCTGTGCTCTTCTCTTCCGGTCGGATCTCTCTCCTCTCTGACCTGGATACGCTTTGGTTTCTCAACTTCTCTACCCCAAAGAA
AAGATTATTCAATAAAGTTTCCTGCCTTTCTGCAAACATAGATGATTGGTTTCCCTTCCTCAGCAGAAAGCGGGGCTGGAGAACACGGTG
GCAGAGACGGAGTGCCGCTATGCCCTGCAGCTGCAGCAGATCCAGGGACTCATCAGCAGCATCGAGGCCCAGCTGAGCGAGCTCCGCAGT
GAGATGGAGTGCCAGAACCAAGAGTACAAGATGCTGCTGGACATCAAGACACGTCTGGAGCAGGAGATCGCCACCTACCGCAGCCTGCTC
GAGGGCCAGGACGCCAAAGTGCAGAGCTGAACAAGGAGGTGTCTACCAACACTGCCATGATTCAGACCAGCAAGACAGAGATCACGGAGC
TCAGGCGCACGCTCCAAGGCCTGGAGATTGAGCTGCAGTCCCAGCTGAGCATGGAGATGAAGGAATTTAGCAACCAGGTGGTCGGCCAGG
TCAACGTGGAGATGGATGCCACCCCAGGCATTGACCTGACCCGCGTGCTGGCAGAGATGAGGGAGCAGTACGAGGCCATGGCAGAGAGGA
ACCGCCGGGATGCTGAGGAATGGTTCCACACCAAGGTATGAGAATGAGCTGGCCCTGCGCCAGAGCGTGGAGGCCGACATCAACGGCCTG
CGCCGGGTGCTGGATGAGCTCACTCTGTCTAAGACTGACCTGGAGATGCAGATCGAGAGCCTGAATGAAGAGCTAGCCTACATGAAGAAG
AACCATGAAGAGATCCTGACCGCCACCATTGAAAACAACCGGGTCATCCTGGAGATTGACAATGCCAGGCTGGCTGCGGACGACTTCAGG
CTCAAGCTGGTAGTGGCTTTGGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTTTGGTGGGGGTT
TTGCTGGTGGCTTTGTTGACTTTGGTGCTTGTGATGGCGGCCTCCTCACTGGCAATGAGAAGATCACCATGCAGAACCTCAACGACCGCC
TGGCTTCCTACCTGGAGAAGGTGCGCGCCCTGGAGGAGGCCAACGCTGACCTGGAGGTGAAGATCCGTGACTGGCACCTGAAGCAGAGCC

>86060_86060_1_SPRR3-KRT13_SPRR3_chr1_152975574_ENST00000542696_KRT13_chr17_39661634_ENST00000246635_length(amino acids)=166AA_BP=8
MLRNGSTPRYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEILTATIENNRVILEIDNARLAADDFRLKL

--------------------------------------------------------------
>86060_86060_2_SPRR3-KRT13_SPRR3_chr1_152975574_ENST00000542696_KRT13_chr17_39661634_ENST00000336861_length(transcript)=1656nt_BP=198nt
CCTCCACCTCAGGAAATATTTGTTCCCACAACCAAGGAGCCATGCCACTCAAAGGTTCCACAACCTGGAAACACAAAGATTCCAGAGCCA
GGCTGTACCAAGGTCCCTGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGTTGTACCAAGGTCCCT
GAGCCAGGCTGTACCAAGGAAGCGTCAGCCCCCGTAGCACCTCTGTTACCACGACTTCTAGTGCCTCTGTTACCACCACCTCTAATGCCT
CTGGTCGCCGCACTTCTGATGTCCGTAGGCCTTAAATCTGCCTGGCGTCCCCTCCCTCTGTCTTCAGCACCCAGAGGAGGAGAGAGCCGG
CAGTTCCCTGCAGGAGAGAGGAGGGGCTGCTGGACCCAAGGCTCAGTCCCTCTGCTCTCAGGACCCCCTGTCCTGACTCTCTCCTGATGG
TGGGCCCTCTGTGCTCTTCTCTTCCGGTCGGATCTCTCTCCTCTCTGACCTGGATACGCTTTGGTTTCTCAACTTCTCTACCCCAAAGAA
AAGATTATTCAATAAAGTTTCCTGCCTTTCTGCAAACATAAAAGCGGGGCTGGAGAACACGGTGGCAGAGACGGAGTGCCGCTATGCCCT
GCAGCTGCAGCAGATCCAGGGACTCATCAGCAGCATCGAGGCCCAGCTGAGCGAGCTCCGCAGTGAGATGGAGTGCCAGAACCAAGAGTA
CAAGATGCTGCTGGACATCAAGACACGTCTGGAGCAGGAGATCGCCACCTACCGCAGCCTGCTCGAGGGCCAGGACGCCAAAGTGCAGAG
CTGAACAAGGAGGTGTCTACCAACACTGCCATGATTCAGACCAGCAAGACAGAGATCACGGAGCTCAGGCGCACGCTCCAAGGCCTGGAG
ATTGAGCTGCAGTCCCAGCTGAGCATGGAGATGAAGGAATTTAGCAACCAGGTGGTCGGCCAGGTCAACGTGGAGATGGATGCCACCCCA
GGCATTGACCTGACCCGCGTGCTGGCAGAGATGAGGGAGCAGTACGAGGCCATGGCAGAGAGGAACCGCCGGGATGCTGAGGAATGGTTC
CACACCAAGGTATGAGAATGAGCTGGCCCTGCGCCAGAGCGTGGAGGCCGACATCAACGGCCTGCGCCGGGTGCTGGATGAGCTCACTCT
GTCTAAGACTGACCTGGAGATGCAGATCGAGAGCCTGAATGAAGAGCTAGCCTACATGAAGAAGAACCATGAAGAGATCCTGACCGCCAC
CATTGAAAACAACCGGGTCATCCTGGAGATTGACAATGCCAGGCTGGCTGCGGACGACTTCAGGCTCAAGCTGGTAGTGGCTTTGGAGGT
GGCTATGGAGGTGGCCTTGGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTTTGGTGGGGGTTTTGCTGGTGGCTTTGTTGACTTTGGT
GCTTGTGATGGCGGCCTCCTCACTGGCAATGAGAAGATCACCATGCAGAACCTCAACGACCGCCTGGCTTCCTACCTGGAGAAGGTGCGC
GCCCTGGAGGAGGCCAACGCTGACCTGGAGGTGAAGATCCGTGACTGGCACCTGAAGCAGAGCCCAGCTAGCCCTGAGCGGGACTACAGC

>86060_86060_2_SPRR3-KRT13_SPRR3_chr1_152975574_ENST00000542696_KRT13_chr17_39661634_ENST00000336861_length(amino acids)=166AA_BP=8
MLRNGSTPRYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEILTATIENNRVILEIDNARLAADDFRLKL

--------------------------------------------------------------
>86060_86060_3_SPRR3-KRT13_SPRR3_chr1_152975574_ENST00000542696_KRT13_chr17_39661634_ENST00000587544_length(transcript)=1423nt_BP=198nt
CCTCCACCTCAGGAAATATTTGTTCCCACAACCAAGGAGCCATGCCACTCAAAGGTTCCACAACCTGGAAACACAAAGATTCCAGAGCCA
GGCTGTACCAAGGTCCCTGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGTTGTACCAAGGTCCCT
GAGCCAGGCTGTACCAAGAAAGCGGGGCTGGAGAACACGGTGGCAGAGACGGAGTGCCGCTATGCCCTGCAGCTGCAGCAGATCCAGGGA
CTCATCAGCAGCATCGAGGCCCAGCTGAGCGAGCTCCGCAGTGAGATGGAGTGCCAGAACCAAGAGTACAAGATGCTGCTGGACATCAAG
ACACGTCTGGAGCAGGAGATCGCCACCTACCGCAGCCTGCTCGAGGGCCAGGACGCCAAGTAGGTCCTCTCCAGCCTCTTTCTTAGGATA
GTGACTGCAGGACCCGTGGGTGTCAGAGCAGGCAGGGCCTTAGAGATCCACCCCCTCATGTCAGAGAGGAGACCCCTCACTGTCTGACTT
TACGGGGACATTTCCTTGGTAGGCTGCAAGTGCAGAGCTGAACAAGGAGGTGTCTACCAACACTGCCATGATTCAGACCAGCAAGACAGA
GATCACGGAGCTCAGGCGCACGCTCCAAGGCCTGGAGATTGAGCTGCAGTCCCAGCTGAGCATGGAGATGAAGGAATTTAGCAACCAGGT
GGTCGGCCAGGTCAACGTGGAGATGGATGCCACCCCAGGCATTGACCTGACCCGCGTGCTGGCAGAGATGAGGGAGCAGTACGAGGCCAT
GGCAGAGAGGAACCGCCGGGATGCTGAGGAATGGTTCCACACCAAGGTATGAGAATGAGCTGGCCCTGCGCCAGAGCGTGGAGGCCGACA
TCAACGGCCTGCGCCGGGTGCTGGATGAGCTCACTCTGTCTAAGACTGACCTGGAGATGCAGATCGAGAGCCTGAATGAAGAGCTAGCCT
ACATGAAGAAGAACCATGAAGAGATCCTGACCGCCACCATTGAAAACAACCGGGTCATCCTGGAGATTGACAATGCCAGGCTGGCTGCGG
ACGACTTCAGGCTCAAGCTGGTAGTGGCTTTGGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTT
TGGTGGGGGTTTTGCTGGTGGCTTTGTTGACTTTGGTGCTTGTGATGGCGGCCTCCTCACTGGCAATGAGAAGATCACCATGCAGAACCT
CAACGACCGCCTGGCTTCCTACCTGGAGAAGGTGCGCGCCCTGGAGGAGGCCAACGCTGACCTGGAGGTGAAGATCCGTGACTGGCACCT

>86060_86060_3_SPRR3-KRT13_SPRR3_chr1_152975574_ENST00000542696_KRT13_chr17_39661634_ENST00000587544_length(amino acids)=166AA_BP=8
MLRNGSTPRYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEILTATIENNRVILEIDNARLAADDFRLKL

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Fusion Gene PPI Analysis for SPRR3-KRT13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPRR3-KRT13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPRR3-KRT13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource