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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPSB4-ACPL2 (FusionGDB2 ID:86090)

Fusion Gene Summary for SPSB4-ACPL2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPSB4-ACPL2
Fusion gene ID: 86090
HgeneTgene
Gene symbol

SPSB4

ACPL2

Gene ID

92369

92370

Gene namesplA/ryanodine receptor domain and SOCS box containing 42-phosphoxylose phosphatase 1
SynonymsSSB-4|SSB4ACPL2|HEL124|XYLP
Cytomap

3q23

3q23

Type of geneprotein-codingprotein-coding
DescriptionSPRY domain-containing SOCS box protein 4SPRY domain-containing SOCS box protein SSB-42-phosphoxylose phosphatase 1acid phosphatase-like 2acid phosphatase-like protein 2epididymis luminal protein 124xylosyl phosphatase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310546, ENST00000507895, 
ENST00000286353, ENST00000393010, 
ENST00000502783, ENST00000393007, 
ENST00000504264, ENST00000505502, 
ENST00000508812, 
Fusion gene scores* DoF score2 X 3 X 3=185 X 4 X 6=120
# samples 49
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/120*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPSB4 [Title/Abstract] AND ACPL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPSB4(140785640)-ACPL2(140978965), # samples:51
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPSB4

GO:0006511

ubiquitin-dependent protein catabolic process

21199876

HgeneSPSB4

GO:0016567

protein ubiquitination

21199876

HgeneSPSB4

GO:1902916

positive regulation of protein polyubiquitination

28931592

TgeneACPL2

GO:0006024

glycosaminoglycan biosynthetic process

24425863


check buttonFusion gene breakpoints across SPSB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ACPL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SK-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4BRCATCGA-A8-A08L-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4BRCATCGA-AR-A0TP-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-02-0055-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-02-2483-01ASPSB4chr3

140770834

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-0129-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-0152-02ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-0158-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-0211-01BSPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-0211SPSB4chr3

140785640

+ACPL2chr3

140978964

+
ChimerDB4GBMTCGA-06-0221-02ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-0646-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-0745-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-2562-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-2565-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-5413-01ASPSB4chr3

140770834

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-06-5413-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-19-2619-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-19-2624-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-19-5960-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-26-1442-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-27-2528-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-28-2514-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-28-5204-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-28-5208-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-28-5208SPSB4chr3

140785640

+ACPL2chr3

140978964

+
ChimerDB4GBMTCGA-41-2571-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-41-5651-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4GBMTCGA-76-4927-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4KICHTCGA-KL-8330-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4KICHTCGA-KL-8336-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4KICHTCGA-KM-8443-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4KICHTCGA-KN-8418-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-CS-4943SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-DB-A64WSPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-DU-5852SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-DU-6392SPSB4chr3

140770834

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-DU-6392SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-DU-6396SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-DU-7302SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-DU-8166SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-E1-5304SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-E1-5318SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-HT-8564SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-S9-A6WESPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-S9-A89VSPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LGGTCGA-TM-A84ISPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LUSCTCGA-22-5480SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4LUSCTCGA-56-8307SPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4PCPGTCGA-P7-A5NY-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4PCPGTCGA-QR-A70E-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4PCPGTCGA-QT-A7U0-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4PCPGTCGA-SR-A6MT-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4PCPGTCGA-TT-A6YN-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4PCPGTCGA-WB-A817-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+
ChimerDB4PCPGTCGA-WB-A81Q-01ASPSB4chr3

140785640

+ACPL2chr3

140978965

+


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Fusion Gene ORF analysis for SPSB4-ACPL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000310546ENST00000286353SPSB4chr3

140785640

+ACPL2chr3

140978965

+
5CDS-5UTRENST00000310546ENST00000286353SPSB4chr3

140785640

+ACPL2chr3

140978964

+
5CDS-5UTRENST00000310546ENST00000393010SPSB4chr3

140785640

+ACPL2chr3

140978965

+
5CDS-5UTRENST00000310546ENST00000393010SPSB4chr3

140785640

+ACPL2chr3

140978964

+
5CDS-5UTRENST00000310546ENST00000502783SPSB4chr3

140785640

+ACPL2chr3

140978965

+
5CDS-5UTRENST00000310546ENST00000502783SPSB4chr3

140785640

+ACPL2chr3

140978964

+
5CDS-intronENST00000310546ENST00000393007SPSB4chr3

140785640

+ACPL2chr3

140978965

+
5CDS-intronENST00000310546ENST00000393007SPSB4chr3

140785640

+ACPL2chr3

140978964

+
5CDS-intronENST00000310546ENST00000504264SPSB4chr3

140785640

+ACPL2chr3

140978965

+
5CDS-intronENST00000310546ENST00000504264SPSB4chr3

140785640

+ACPL2chr3

140978964

+
5CDS-intronENST00000310546ENST00000505502SPSB4chr3

140785640

+ACPL2chr3

140978965

+
5CDS-intronENST00000310546ENST00000505502SPSB4chr3

140785640

+ACPL2chr3

140978964

+
5CDS-intronENST00000310546ENST00000508812SPSB4chr3

140785640

+ACPL2chr3

140978965

+
5CDS-intronENST00000310546ENST00000508812SPSB4chr3

140785640

+ACPL2chr3

140978964

+
5UTR-5UTRENST00000310546ENST00000286353SPSB4chr3

140770834

+ACPL2chr3

140978965

+
5UTR-5UTRENST00000310546ENST00000393010SPSB4chr3

140770834

+ACPL2chr3

140978965

+
5UTR-5UTRENST00000310546ENST00000502783SPSB4chr3

140770834

+ACPL2chr3

140978965

+
5UTR-intronENST00000310546ENST00000393007SPSB4chr3

140770834

+ACPL2chr3

140978965

+
5UTR-intronENST00000310546ENST00000504264SPSB4chr3

140770834

+ACPL2chr3

140978965

+
5UTR-intronENST00000310546ENST00000505502SPSB4chr3

140770834

+ACPL2chr3

140978965

+
5UTR-intronENST00000310546ENST00000508812SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-5UTRENST00000507895ENST00000286353SPSB4chr3

140785640

+ACPL2chr3

140978965

+
intron-5UTRENST00000507895ENST00000286353SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-5UTRENST00000507895ENST00000286353SPSB4chr3

140785640

+ACPL2chr3

140978964

+
intron-5UTRENST00000507895ENST00000393010SPSB4chr3

140785640

+ACPL2chr3

140978965

+
intron-5UTRENST00000507895ENST00000393010SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-5UTRENST00000507895ENST00000393010SPSB4chr3

140785640

+ACPL2chr3

140978964

+
intron-5UTRENST00000507895ENST00000502783SPSB4chr3

140785640

+ACPL2chr3

140978965

+
intron-5UTRENST00000507895ENST00000502783SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-5UTRENST00000507895ENST00000502783SPSB4chr3

140785640

+ACPL2chr3

140978964

+
intron-intronENST00000507895ENST00000393007SPSB4chr3

140785640

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000393007SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000393007SPSB4chr3

140785640

+ACPL2chr3

140978964

+
intron-intronENST00000507895ENST00000504264SPSB4chr3

140785640

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000504264SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000504264SPSB4chr3

140785640

+ACPL2chr3

140978964

+
intron-intronENST00000507895ENST00000505502SPSB4chr3

140785640

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000505502SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000505502SPSB4chr3

140785640

+ACPL2chr3

140978964

+
intron-intronENST00000507895ENST00000508812SPSB4chr3

140785640

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000508812SPSB4chr3

140770834

+ACPL2chr3

140978965

+
intron-intronENST00000507895ENST00000508812SPSB4chr3

140785640

+ACPL2chr3

140978964

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SPSB4-ACPL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPSB4chr3140770834+ACPL2chr3140978964+0.0008980570.999102
SPSB4chr3140785640+ACPL2chr3140978964+6.28E-050.9999372
SPSB4chr3140785640+ACPL2chr3140978964+6.28E-050.9999372
SPSB4chr3140770834+ACPL2chr3140978964+0.0008980570.999102
SPSB4chr3140785640+ACPL2chr3140978964+6.28E-050.9999372
SPSB4chr3140785640+ACPL2chr3140978964+6.28E-050.9999372

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPSB4-ACPL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:140785640/:140978965)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SPSB4-ACPL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SPSB4-ACPL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPSB4-ACPL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPSB4-ACPL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource