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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPTAN1-CEP250 (FusionGDB2 ID:86097)

Fusion Gene Summary for SPTAN1-CEP250

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTAN1-CEP250
Fusion gene ID: 86097
HgeneTgene
Gene symbol

SPTAN1

CEP250

Gene ID

6709

11190

Gene namespectrin alpha, non-erythrocytic 1centrosomal protein 250
SynonymsEIEE5|NEAS|SPTA2C-NAP1|CEP2|CNAP1|CRDHL2
Cytomap

9q34.11

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionspectrin alpha chain, non-erythrocytic 1alpha-II spectrinalpha-fodrinepididymis secretory sperm binding proteinfodrin alpha chainspectrin, non-erythroid alpha chainspectrin, non-erythroid alpha subunitcentrosome-associated protein CEP250250 kDa centrosomal proteincentrosomal Nek2-associated protein 1
Modification date2020031320200313
UniProtAcc.

Q9BV73

Ensembl transtripts involved in fusion geneENST00000358161, ENST00000372731, 
ENST00000372739, ENST00000475367, 
ENST00000397524, ENST00000476146, 
ENST00000342580, ENST00000397527, 
Fusion gene scores* DoF score20 X 20 X 10=40008 X 9 X 6=432
# samples 269
** MAII scorelog2(26/4000*10)=-3.94341647163363
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTAN1 [Title/Abstract] AND CEP250 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPTAN1(131340524)-CEP250(34090217), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCEP250

GO:0000278

mitotic cell cycle

12140259

TgeneCEP250

GO:0030997

regulation of centriole-centriole cohesion

9647649


check buttonFusion gene breakpoints across SPTAN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP250 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8381SPTAN1chr9

131340524

+CEP250chr20

34090217

+


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Fusion Gene ORF analysis for SPTAN1-CEP250

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358161ENST00000397524SPTAN1chr9

131340524

+CEP250chr20

34090217

+
5CDS-intronENST00000358161ENST00000476146SPTAN1chr9

131340524

+CEP250chr20

34090217

+
5CDS-intronENST00000372731ENST00000397524SPTAN1chr9

131340524

+CEP250chr20

34090217

+
5CDS-intronENST00000372731ENST00000476146SPTAN1chr9

131340524

+CEP250chr20

34090217

+
5CDS-intronENST00000372739ENST00000397524SPTAN1chr9

131340524

+CEP250chr20

34090217

+
5CDS-intronENST00000372739ENST00000476146SPTAN1chr9

131340524

+CEP250chr20

34090217

+
In-frameENST00000358161ENST00000342580SPTAN1chr9

131340524

+CEP250chr20

34090217

+
In-frameENST00000358161ENST00000397527SPTAN1chr9

131340524

+CEP250chr20

34090217

+
In-frameENST00000372731ENST00000342580SPTAN1chr9

131340524

+CEP250chr20

34090217

+
In-frameENST00000372731ENST00000397527SPTAN1chr9

131340524

+CEP250chr20

34090217

+
In-frameENST00000372739ENST00000342580SPTAN1chr9

131340524

+CEP250chr20

34090217

+
In-frameENST00000372739ENST00000397527SPTAN1chr9

131340524

+CEP250chr20

34090217

+
intron-3CDSENST00000475367ENST00000342580SPTAN1chr9

131340524

+CEP250chr20

34090217

+
intron-3CDSENST00000475367ENST00000397527SPTAN1chr9

131340524

+CEP250chr20

34090217

+
intron-intronENST00000475367ENST00000397524SPTAN1chr9

131340524

+CEP250chr20

34090217

+
intron-intronENST00000475367ENST00000476146SPTAN1chr9

131340524

+CEP250chr20

34090217

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358161SPTAN1chr9131340524+ENST00000397527CEP250chr2034090217+499213341146421543
ENST00000358161SPTAN1chr9131340524+ENST00000342580CEP250chr2034090217+499013341146421543
ENST00000372739SPTAN1chr9131340524+ENST00000397527CEP250chr2034090217+49891331846391543
ENST00000372739SPTAN1chr9131340524+ENST00000342580CEP250chr2034090217+49871331846391543
ENST00000372731SPTAN1chr9131340524+ENST00000397527CEP250chr2034090217+49891331846391543
ENST00000372731SPTAN1chr9131340524+ENST00000342580CEP250chr2034090217+49871331846391543

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358161ENST00000397527SPTAN1chr9131340524+CEP250chr2034090217+0.0231575130.9768424
ENST00000358161ENST00000342580SPTAN1chr9131340524+CEP250chr2034090217+0.0231373890.97686255
ENST00000372739ENST00000397527SPTAN1chr9131340524+CEP250chr2034090217+0.0231108390.9768892
ENST00000372739ENST00000342580SPTAN1chr9131340524+CEP250chr2034090217+0.0230907240.97690934
ENST00000372731ENST00000397527SPTAN1chr9131340524+CEP250chr2034090217+0.0231108390.9768892
ENST00000372731ENST00000342580SPTAN1chr9131340524+CEP250chr2034090217+0.0230907240.97690934

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Fusion Genomic Features for SPTAN1-CEP250


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPTAN1chr9131340524+CEP250chr2034090217+4.86E-060.9999951
SPTAN1chr9131340524+CEP250chr2034090217+4.86E-060.9999951

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPTAN1-CEP250


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131340524/chr20:34090217)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP250

Q9BV73

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be involved in ciliogenesis (PubMed:28005958). Probably plays an important role in centrosome cohesion during interphase. {ECO:0000269|PubMed:28005958}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956150_2514072473.0RepeatSpectrin 2
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956256_3584072473.0RepeatSpectrin 3
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+95645_1464072473.0RepeatSpectrin 1
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957150_2514072478.0RepeatSpectrin 2
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957256_3584072478.0RepeatSpectrin 3
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+95745_1464072478.0RepeatSpectrin 1
TgeneCEP250chr9:131340524chr20:34090217ENST0000034258027342262_237612842387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST0000039752728352262_237613402443.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9562336_23474072473.0Calcium binding1
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9562379_23904072473.0Calcium binding2
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9572336_23474072478.0Calcium binding1
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9572379_23904072478.0Calcium binding2
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9562323_23584072473.0DomainEF-hand 1
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9562366_24014072473.0DomainEF-hand 2
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9562404_24394072473.0DomainEF-hand 3
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956967_10264072473.0DomainSH3
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9572323_23584072478.0DomainEF-hand 1
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9572366_24014072478.0DomainEF-hand 2
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9572404_24394072478.0DomainEF-hand 3
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957967_10264072478.0DomainSH3
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561096_11664072473.0RepeatSpectrin 10
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561233_13364072473.0RepeatSpectrin 11
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561339_14424072473.0RepeatSpectrin 12
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561446_15494072473.0RepeatSpectrin 13
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561552_16564072473.0RepeatSpectrin 14
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561659_17624072473.0RepeatSpectrin 15
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561764_18684072473.0RepeatSpectrin 16
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561871_19744072473.0RepeatSpectrin 17
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9561978_20814072473.0RepeatSpectrin 18
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9562092_21944072473.0RepeatSpectrin 19
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+9562206_23104072473.0RepeatSpectrin 20
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956361_4654072473.0RepeatSpectrin 4
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956468_5704072473.0RepeatSpectrin 5
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956574_6764072473.0RepeatSpectrin 6
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956679_7814072473.0RepeatSpectrin 7
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956785_8884072473.0RepeatSpectrin 8
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372731+956891_9694072473.0RepeatSpectrin 9
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571096_11664072478.0RepeatSpectrin 10
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571233_13364072478.0RepeatSpectrin 11
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571339_14424072478.0RepeatSpectrin 12
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571446_15494072478.0RepeatSpectrin 13
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571552_16564072478.0RepeatSpectrin 14
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571659_17624072478.0RepeatSpectrin 15
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571764_18684072478.0RepeatSpectrin 16
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571871_19744072478.0RepeatSpectrin 17
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9571978_20814072478.0RepeatSpectrin 18
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9572092_21944072478.0RepeatSpectrin 19
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+9572206_23104072478.0RepeatSpectrin 20
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957361_4654072478.0RepeatSpectrin 4
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957468_5704072478.0RepeatSpectrin 5
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957574_6764072478.0RepeatSpectrin 6
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957679_7814072478.0RepeatSpectrin 7
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957785_8884072478.0RepeatSpectrin 8
HgeneSPTAN1chr9:131340524chr20:34090217ENST00000372739+957891_9694072478.0RepeatSpectrin 9
TgeneCEP250chr9:131340524chr20:34090217ENST0000034258027341243_222712842387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST000003425802734244_35212842387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST000003425802734395_117212842387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST00000342580273495_15812842387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST0000039752728351243_222713402443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST000003975272835244_35213402443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST000003975272835395_117213402443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST00000397527283595_15813402443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr9:131340524chr20:34090217ENST000003425802734246_25012842387.0Compositional biasNote=Poly-Leu
TgeneCEP250chr9:131340524chr20:34090217ENST000003425802734464_217112842387.0Compositional biasNote=Gln/Glu-rich
TgeneCEP250chr9:131340524chr20:34090217ENST000003975272835246_25013402443.0Compositional biasNote=Poly-Leu
TgeneCEP250chr9:131340524chr20:34090217ENST000003975272835464_217113402443.0Compositional biasNote=Gln/Glu-rich


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Fusion Gene Sequence for SPTAN1-CEP250


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86097_86097_1_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000358161_CEP250_chr20_34090217_ENST00000342580_length(transcript)=4990nt_BP=1334nt
GCCACTACCCGCTGCGGAGTGAACGGTGTGGAGCGGAGGCCGCGGAGGCTCCTCGGTCCTTCAGCACCCCTCGGCCCGACGCACCCACGC
CCCTCACCCCCCGAGAGCCGAAAATGGACCCAAGTGGGGTCAAAGTGCTGGAAACAGCAGAGGACATCCAGGAGAGGCGGCAGCAGGTCC
TAGACCGATACCACCGCTTCAAGGAACTCTCAACCCTTAGGCGTCAGAAGCTGGAAGATTCCTATCGATTCCAGTTCTTTCAAAGAGATG
CTGAAGAGCTGGAGAAATGGATACAGGAAAAACTTCAGATTGCATCTGATGAGAATTATAAAGACCCAACCAACTTGCAGGGAAAGCTTC
AGAAGCATCAAGCATTTGAAGCTGAAGTGCAGGCCAACTCAGGAGCCATTGTTAAGCTGGATGAAACTGGAAACCTGATGATCTCAGAAG
GGCATTTTGCATCTGAAACCATACGGACCCGTTTGATGGAGCTGCACCGCCAGTGGGAATTACTTTTGGAGAAGATGCGAGAAAAAGGAA
TCAAACTGCTGCAGGCCCAGAAGTTGGTGCAGTACTTACGAGAATGTGAGGACGTGATGGACTGGATCAATGACAAGGAAGCAATTGTTA
CTTCTGAAGAGCTGGGCCAGGATCTGGAGCATGTAGAGGTTTTACAGAAGAAATTTGAAGAGTTTCAAACAGATATGGCTGCTCATGAAG
AAAGAGTTAATGAAGTGAACCAGTTTGCTGCCAAACTCATACAGGAGCAGCACCCTGAGGAGGAACTGATCAAGACTAAGCAGGATGAAG
TCAATGCAGCCTGGCAGCGGCTGAAGGGCCTGGCTCTGCAGAGGCAGGGGAAGCTCTTTGGGGCAGCAGAAGTTCAGCGCTTTAACAGGG
ATGTGGATGAGACTATCAGTTGGATTAAGGAAAAGGAGCAGTTAATGGCCTCTGATGATTTTGGCCGAGACCTGGCAAGTGTTCAGGCTC
TGCTTCGGAAGCACGAGGGTCTGGAGAGAGATCTTGCTGCTCTAGAAGACAAGGTCAAAGCCCTGTGTGCTGAGGCTGACCGCCTGCAAC
AGTCCCACCCTCTGAGTGCAACACAGATTCAAGTGAAGCGAGAGGAACTGATTACAAACTGGGAGCAGATCCGCACCTTGGCGGCAGAGA
GACATGCACGGCTCAATGATTCATACAGGCTTCAACGCTTCCTTGCTGACTTCCGTGACCTCACCAGCTGGGTGACTGAGATGAAAGCCC
TCATCAATGCAGATGAGCTTGCCAGTGATGTGGCTGGGGCTGAAGCCCTGCTAGATAGACACCAAGAGCACAAGGGTGAGCGAGAGTTAC
TTCAGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCA
TCCTGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGC
AAGAGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGG
AGGTGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGA
AGAAGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCG
TCCAGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGC
ATCAGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGG
AATGCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCC
AGAGAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGA
GCCACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGA
AAGAGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCC
GGCAGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGA
TGCAGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGA
AGGAGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGG
TAGGTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGC
TGAAGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAAC
AGCAGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGG
AGCGTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGG
AGGAGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGG
AGCATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGC
GGGCAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTG
CCCTGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGG
ATGCCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGACCAGGATCTCCGATACCAGGAGG
ATGTGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGG
CCCAGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTG
TAAGGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTAC
CCCACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTAC
AGGCAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCA
GTGTCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGG
AGCTCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTG
TGCAGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGC
AGCAAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAG
AACGGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCCACGGCTTCTTCACCCACACAGC
AGGATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGG
AGCGGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCACCACAGCCTCTCACACTCACTTC
TTGCCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAG
GGCCAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGAGCACACAGACAGAAGACTGTGT
CATGGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTG
TTCCCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGG
AATCACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTCCTAGCACTTCACCACCTCCTTC

>86097_86097_1_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000358161_CEP250_chr20_34090217_ENST00000342580_length(amino acids)=1543AA_BP=441
MRSERCGAEAAEAPRSFSTPRPDAPTPLTPREPKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEEL
EKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL
QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA
WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP
LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGERELLQAA
KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET
LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL
ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST
VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER
AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ
SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL
GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG
KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV
QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL
RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG
EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGR
GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL

--------------------------------------------------------------
>86097_86097_2_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000358161_CEP250_chr20_34090217_ENST00000397527_length(transcript)=4992nt_BP=1334nt
GCCACTACCCGCTGCGGAGTGAACGGTGTGGAGCGGAGGCCGCGGAGGCTCCTCGGTCCTTCAGCACCCCTCGGCCCGACGCACCCACGC
CCCTCACCCCCCGAGAGCCGAAAATGGACCCAAGTGGGGTCAAAGTGCTGGAAACAGCAGAGGACATCCAGGAGAGGCGGCAGCAGGTCC
TAGACCGATACCACCGCTTCAAGGAACTCTCAACCCTTAGGCGTCAGAAGCTGGAAGATTCCTATCGATTCCAGTTCTTTCAAAGAGATG
CTGAAGAGCTGGAGAAATGGATACAGGAAAAACTTCAGATTGCATCTGATGAGAATTATAAAGACCCAACCAACTTGCAGGGAAAGCTTC
AGAAGCATCAAGCATTTGAAGCTGAAGTGCAGGCCAACTCAGGAGCCATTGTTAAGCTGGATGAAACTGGAAACCTGATGATCTCAGAAG
GGCATTTTGCATCTGAAACCATACGGACCCGTTTGATGGAGCTGCACCGCCAGTGGGAATTACTTTTGGAGAAGATGCGAGAAAAAGGAA
TCAAACTGCTGCAGGCCCAGAAGTTGGTGCAGTACTTACGAGAATGTGAGGACGTGATGGACTGGATCAATGACAAGGAAGCAATTGTTA
CTTCTGAAGAGCTGGGCCAGGATCTGGAGCATGTAGAGGTTTTACAGAAGAAATTTGAAGAGTTTCAAACAGATATGGCTGCTCATGAAG
AAAGAGTTAATGAAGTGAACCAGTTTGCTGCCAAACTCATACAGGAGCAGCACCCTGAGGAGGAACTGATCAAGACTAAGCAGGATGAAG
TCAATGCAGCCTGGCAGCGGCTGAAGGGCCTGGCTCTGCAGAGGCAGGGGAAGCTCTTTGGGGCAGCAGAAGTTCAGCGCTTTAACAGGG
ATGTGGATGAGACTATCAGTTGGATTAAGGAAAAGGAGCAGTTAATGGCCTCTGATGATTTTGGCCGAGACCTGGCAAGTGTTCAGGCTC
TGCTTCGGAAGCACGAGGGTCTGGAGAGAGATCTTGCTGCTCTAGAAGACAAGGTCAAAGCCCTGTGTGCTGAGGCTGACCGCCTGCAAC
AGTCCCACCCTCTGAGTGCAACACAGATTCAAGTGAAGCGAGAGGAACTGATTACAAACTGGGAGCAGATCCGCACCTTGGCGGCAGAGA
GACATGCACGGCTCAATGATTCATACAGGCTTCAACGCTTCCTTGCTGACTTCCGTGACCTCACCAGCTGGGTGACTGAGATGAAAGCCC
TCATCAATGCAGATGAGCTTGCCAGTGATGTGGCTGGGGCTGAAGCCCTGCTAGATAGACACCAAGAGCACAAGGGTGAGCGAGAGTTAC
TTCAGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCA
TCCTGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGC
AAGAGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGG
AGGTGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGA
AGAAGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCG
TCCAGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGC
ATCAGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGG
AATGCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCC
AGAGAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGA
GCCACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGA
AAGAGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCC
GGCAGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGA
TGCAGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGA
AGGAGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGG
TAGGTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGC
TGAAGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAAC
AGCAGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGG
AGCGTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGG
AGGAGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGG
AGCATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGC
GGGCAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTG
CCCTGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGG
ATGCCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGACCAGGATCTCCGATACCAGGAGG
ATGTGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGG
CCCAGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTG
TAAGGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTAC
CCCACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTAC
AGGCAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCA
GTGTCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGG
AGCTCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTG
TGCAGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGC
AGCAAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAG
AACGGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCCACGGCTTCTTCACCCACACAGC
AGGATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGG
AGCGGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCACCACAGCCTCTCACACTCACTTC
TTGCCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAG
GGCCAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGAGCACACAGACAGAAGACTGTGT
CATGGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTG
TTCCCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGG
AATCACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTCCTAGCACTTCACCACCTCCTTC

>86097_86097_2_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000358161_CEP250_chr20_34090217_ENST00000397527_length(amino acids)=1543AA_BP=441
MRSERCGAEAAEAPRSFSTPRPDAPTPLTPREPKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEEL
EKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL
QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA
WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP
LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGERELLQAA
KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET
LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL
ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST
VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER
AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ
SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL
GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG
KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV
QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL
RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG
EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGR
GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL

--------------------------------------------------------------
>86097_86097_3_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372731_CEP250_chr20_34090217_ENST00000342580_length(transcript)=4987nt_BP=1331nt
ACTACCCGCTGCGGAGTGAACGGTGTGGAGCGGAGGCCGCGGAGGCTCCTCGGTCCTTCAGCACCCCTCGGCCCGACGCACCCACGCCCC
TCACCCCCCGAGAGCCGAAAATGGACCCAAGTGGGGTCAAAGTGCTGGAAACAGCAGAGGACATCCAGGAGAGGCGGCAGCAGGTCCTAG
ACCGATACCACCGCTTCAAGGAACTCTCAACCCTTAGGCGTCAGAAGCTGGAAGATTCCTATCGATTCCAGTTCTTTCAAAGAGATGCTG
AAGAGCTGGAGAAATGGATACAGGAAAAACTTCAGATTGCATCTGATGAGAATTATAAAGACCCAACCAACTTGCAGGGAAAGCTTCAGA
AGCATCAAGCATTTGAAGCTGAAGTGCAGGCCAACTCAGGAGCCATTGTTAAGCTGGATGAAACTGGAAACCTGATGATCTCAGAAGGGC
ATTTTGCATCTGAAACCATACGGACCCGTTTGATGGAGCTGCACCGCCAGTGGGAATTACTTTTGGAGAAGATGCGAGAAAAAGGAATCA
AACTGCTGCAGGCCCAGAAGTTGGTGCAGTACTTACGAGAATGTGAGGACGTGATGGACTGGATCAATGACAAGGAAGCAATTGTTACTT
CTGAAGAGCTGGGCCAGGATCTGGAGCATGTAGAGGTTTTACAGAAGAAATTTGAAGAGTTTCAAACAGATATGGCTGCTCATGAAGAAA
GAGTTAATGAAGTGAACCAGTTTGCTGCCAAACTCATACAGGAGCAGCACCCTGAGGAGGAACTGATCAAGACTAAGCAGGATGAAGTCA
ATGCAGCCTGGCAGCGGCTGAAGGGCCTGGCTCTGCAGAGGCAGGGGAAGCTCTTTGGGGCAGCAGAAGTTCAGCGCTTTAACAGGGATG
TGGATGAGACTATCAGTTGGATTAAGGAAAAGGAGCAGTTAATGGCCTCTGATGATTTTGGCCGAGACCTGGCAAGTGTTCAGGCTCTGC
TTCGGAAGCACGAGGGTCTGGAGAGAGATCTTGCTGCTCTAGAAGACAAGGTCAAAGCCCTGTGTGCTGAGGCTGACCGCCTGCAACAGT
CCCACCCTCTGAGTGCAACACAGATTCAAGTGAAGCGAGAGGAACTGATTACAAACTGGGAGCAGATCCGCACCTTGGCGGCAGAGAGAC
ATGCACGGCTCAATGATTCATACAGGCTTCAACGCTTCCTTGCTGACTTCCGTGACCTCACCAGCTGGGTGACTGAGATGAAAGCCCTCA
TCAATGCAGATGAGCTTGCCAGTGATGTGGCTGGGGCTGAAGCCCTGCTAGATAGACACCAAGAGCACAAGGGTGAGCGAGAGTTACTTC
AGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCATCC
TGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGCAAG
AGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGGAGG
TGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGAAGA
AGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCGTCC
AGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGCATC
AGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGGAAT
GCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCCAGA
GAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGAGCC
ACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGAAAG
AGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCCGGC
AGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGATGC
AGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGAAGG
AGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGGTAG
GTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGCTGA
AGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAACAGC
AGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGGAGC
GTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGGAGG
AGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGGAGC
ATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGCGGG
CAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTGCCC
TGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGGATG
CCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGACCAGGATCTCCGATACCAGGAGGATG
TGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGGCCC
AGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTGTAA
GGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTACCCC
ACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTACAGG
CAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCAGTG
TCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGGAGC
TCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTGTGC
AGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGCAGC
AAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAGAAC
GGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCCACGGCTTCTTCACCCACACAGCAGG
ATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGGAGC
GGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCACCACAGCCTCTCACACTCACTTCTTG
CCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAGGGC
CAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGAGCACACAGACAGAAGACTGTGTCAT
GGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTGTTC
CCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGGAAT
CACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTCCTAGCACTTCACCACCTCCTTCATC

>86097_86097_3_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372731_CEP250_chr20_34090217_ENST00000342580_length(amino acids)=1543AA_BP=441
MRSERCGAEAAEAPRSFSTPRPDAPTPLTPREPKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEEL
EKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL
QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA
WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP
LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGERELLQAA
KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET
LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL
ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST
VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER
AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ
SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL
GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG
KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV
QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL
RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG
EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGR
GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL

--------------------------------------------------------------
>86097_86097_4_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372731_CEP250_chr20_34090217_ENST00000397527_length(transcript)=4989nt_BP=1331nt
ACTACCCGCTGCGGAGTGAACGGTGTGGAGCGGAGGCCGCGGAGGCTCCTCGGTCCTTCAGCACCCCTCGGCCCGACGCACCCACGCCCC
TCACCCCCCGAGAGCCGAAAATGGACCCAAGTGGGGTCAAAGTGCTGGAAACAGCAGAGGACATCCAGGAGAGGCGGCAGCAGGTCCTAG
ACCGATACCACCGCTTCAAGGAACTCTCAACCCTTAGGCGTCAGAAGCTGGAAGATTCCTATCGATTCCAGTTCTTTCAAAGAGATGCTG
AAGAGCTGGAGAAATGGATACAGGAAAAACTTCAGATTGCATCTGATGAGAATTATAAAGACCCAACCAACTTGCAGGGAAAGCTTCAGA
AGCATCAAGCATTTGAAGCTGAAGTGCAGGCCAACTCAGGAGCCATTGTTAAGCTGGATGAAACTGGAAACCTGATGATCTCAGAAGGGC
ATTTTGCATCTGAAACCATACGGACCCGTTTGATGGAGCTGCACCGCCAGTGGGAATTACTTTTGGAGAAGATGCGAGAAAAAGGAATCA
AACTGCTGCAGGCCCAGAAGTTGGTGCAGTACTTACGAGAATGTGAGGACGTGATGGACTGGATCAATGACAAGGAAGCAATTGTTACTT
CTGAAGAGCTGGGCCAGGATCTGGAGCATGTAGAGGTTTTACAGAAGAAATTTGAAGAGTTTCAAACAGATATGGCTGCTCATGAAGAAA
GAGTTAATGAAGTGAACCAGTTTGCTGCCAAACTCATACAGGAGCAGCACCCTGAGGAGGAACTGATCAAGACTAAGCAGGATGAAGTCA
ATGCAGCCTGGCAGCGGCTGAAGGGCCTGGCTCTGCAGAGGCAGGGGAAGCTCTTTGGGGCAGCAGAAGTTCAGCGCTTTAACAGGGATG
TGGATGAGACTATCAGTTGGATTAAGGAAAAGGAGCAGTTAATGGCCTCTGATGATTTTGGCCGAGACCTGGCAAGTGTTCAGGCTCTGC
TTCGGAAGCACGAGGGTCTGGAGAGAGATCTTGCTGCTCTAGAAGACAAGGTCAAAGCCCTGTGTGCTGAGGCTGACCGCCTGCAACAGT
CCCACCCTCTGAGTGCAACACAGATTCAAGTGAAGCGAGAGGAACTGATTACAAACTGGGAGCAGATCCGCACCTTGGCGGCAGAGAGAC
ATGCACGGCTCAATGATTCATACAGGCTTCAACGCTTCCTTGCTGACTTCCGTGACCTCACCAGCTGGGTGACTGAGATGAAAGCCCTCA
TCAATGCAGATGAGCTTGCCAGTGATGTGGCTGGGGCTGAAGCCCTGCTAGATAGACACCAAGAGCACAAGGGTGAGCGAGAGTTACTTC
AGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCATCC
TGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGCAAG
AGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGGAGG
TGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGAAGA
AGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCGTCC
AGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGCATC
AGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGGAAT
GCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCCAGA
GAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGAGCC
ACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGAAAG
AGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCCGGC
AGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGATGC
AGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGAAGG
AGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGGTAG
GTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGCTGA
AGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAACAGC
AGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGGAGC
GTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGGAGG
AGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGGAGC
ATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGCGGG
CAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTGCCC
TGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGGATG
CCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGACCAGGATCTCCGATACCAGGAGGATG
TGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGGCCC
AGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTGTAA
GGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTACCCC
ACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTACAGG
CAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCAGTG
TCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGGAGC
TCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTGTGC
AGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGCAGC
AAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAGAAC
GGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCCACGGCTTCTTCACCCACACAGCAGG
ATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGGAGC
GGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCACCACAGCCTCTCACACTCACTTCTTG
CCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAGGGC
CAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGAGCACACAGACAGAAGACTGTGTCAT
GGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTGTTC
CCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGGAAT
CACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTCCTAGCACTTCACCACCTCCTTCATC

>86097_86097_4_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372731_CEP250_chr20_34090217_ENST00000397527_length(amino acids)=1543AA_BP=441
MRSERCGAEAAEAPRSFSTPRPDAPTPLTPREPKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEEL
EKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL
QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA
WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP
LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGERELLQAA
KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET
LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL
ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST
VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER
AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ
SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL
GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG
KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV
QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL
RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG
EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGR
GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL

--------------------------------------------------------------
>86097_86097_5_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372739_CEP250_chr20_34090217_ENST00000342580_length(transcript)=4987nt_BP=1331nt
ACTACCCGCTGCGGAGTGAACGGTGTGGAGCGGAGGCCGCGGAGGCTCCTCGGTCCTTCAGCACCCCTCGGCCCGACGCACCCACGCCCC
TCACCCCCCGAGAGCCGAAAATGGACCCAAGTGGGGTCAAAGTGCTGGAAACAGCAGAGGACATCCAGGAGAGGCGGCAGCAGGTCCTAG
ACCGATACCACCGCTTCAAGGAACTCTCAACCCTTAGGCGTCAGAAGCTGGAAGATTCCTATCGATTCCAGTTCTTTCAAAGAGATGCTG
AAGAGCTGGAGAAATGGATACAGGAAAAACTTCAGATTGCATCTGATGAGAATTATAAAGACCCAACCAACTTGCAGGGAAAGCTTCAGA
AGCATCAAGCATTTGAAGCTGAAGTGCAGGCCAACTCAGGAGCCATTGTTAAGCTGGATGAAACTGGAAACCTGATGATCTCAGAAGGGC
ATTTTGCATCTGAAACCATACGGACCCGTTTGATGGAGCTGCACCGCCAGTGGGAATTACTTTTGGAGAAGATGCGAGAAAAAGGAATCA
AACTGCTGCAGGCCCAGAAGTTGGTGCAGTACTTACGAGAATGTGAGGACGTGATGGACTGGATCAATGACAAGGAAGCAATTGTTACTT
CTGAAGAGCTGGGCCAGGATCTGGAGCATGTAGAGGTTTTACAGAAGAAATTTGAAGAGTTTCAAACAGATATGGCTGCTCATGAAGAAA
GAGTTAATGAAGTGAACCAGTTTGCTGCCAAACTCATACAGGAGCAGCACCCTGAGGAGGAACTGATCAAGACTAAGCAGGATGAAGTCA
ATGCAGCCTGGCAGCGGCTGAAGGGCCTGGCTCTGCAGAGGCAGGGGAAGCTCTTTGGGGCAGCAGAAGTTCAGCGCTTTAACAGGGATG
TGGATGAGACTATCAGTTGGATTAAGGAAAAGGAGCAGTTAATGGCCTCTGATGATTTTGGCCGAGACCTGGCAAGTGTTCAGGCTCTGC
TTCGGAAGCACGAGGGTCTGGAGAGAGATCTTGCTGCTCTAGAAGACAAGGTCAAAGCCCTGTGTGCTGAGGCTGACCGCCTGCAACAGT
CCCACCCTCTGAGTGCAACACAGATTCAAGTGAAGCGAGAGGAACTGATTACAAACTGGGAGCAGATCCGCACCTTGGCGGCAGAGAGAC
ATGCACGGCTCAATGATTCATACAGGCTTCAACGCTTCCTTGCTGACTTCCGTGACCTCACCAGCTGGGTGACTGAGATGAAAGCCCTCA
TCAATGCAGATGAGCTTGCCAGTGATGTGGCTGGGGCTGAAGCCCTGCTAGATAGACACCAAGAGCACAAGGGTGAGCGAGAGTTACTTC
AGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCATCC
TGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGCAAG
AGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGGAGG
TGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGAAGA
AGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCGTCC
AGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGCATC
AGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGGAAT
GCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCCAGA
GAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGAGCC
ACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGAAAG
AGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCCGGC
AGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGATGC
AGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGAAGG
AGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGGTAG
GTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGCTGA
AGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAACAGC
AGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGGAGC
GTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGGAGG
AGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGGAGC
ATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGCGGG
CAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTGCCC
TGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGGATG
CCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGACCAGGATCTCCGATACCAGGAGGATG
TGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGGCCC
AGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTGTAA
GGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTACCCC
ACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTACAGG
CAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCAGTG
TCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGGAGC
TCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTGTGC
AGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGCAGC
AAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAGAAC
GGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCCACGGCTTCTTCACCCACACAGCAGG
ATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGGAGC
GGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCACCACAGCCTCTCACACTCACTTCTTG
CCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAGGGC
CAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGAGCACACAGACAGAAGACTGTGTCAT
GGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTGTTC
CCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGGAAT
CACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTCCTAGCACTTCACCACCTCCTTCATC

>86097_86097_5_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372739_CEP250_chr20_34090217_ENST00000342580_length(amino acids)=1543AA_BP=441
MRSERCGAEAAEAPRSFSTPRPDAPTPLTPREPKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEEL
EKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL
QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA
WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP
LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGERELLQAA
KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET
LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL
ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST
VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER
AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ
SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL
GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG
KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV
QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL
RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG
EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGR
GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL

--------------------------------------------------------------
>86097_86097_6_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372739_CEP250_chr20_34090217_ENST00000397527_length(transcript)=4989nt_BP=1331nt
ACTACCCGCTGCGGAGTGAACGGTGTGGAGCGGAGGCCGCGGAGGCTCCTCGGTCCTTCAGCACCCCTCGGCCCGACGCACCCACGCCCC
TCACCCCCCGAGAGCCGAAAATGGACCCAAGTGGGGTCAAAGTGCTGGAAACAGCAGAGGACATCCAGGAGAGGCGGCAGCAGGTCCTAG
ACCGATACCACCGCTTCAAGGAACTCTCAACCCTTAGGCGTCAGAAGCTGGAAGATTCCTATCGATTCCAGTTCTTTCAAAGAGATGCTG
AAGAGCTGGAGAAATGGATACAGGAAAAACTTCAGATTGCATCTGATGAGAATTATAAAGACCCAACCAACTTGCAGGGAAAGCTTCAGA
AGCATCAAGCATTTGAAGCTGAAGTGCAGGCCAACTCAGGAGCCATTGTTAAGCTGGATGAAACTGGAAACCTGATGATCTCAGAAGGGC
ATTTTGCATCTGAAACCATACGGACCCGTTTGATGGAGCTGCACCGCCAGTGGGAATTACTTTTGGAGAAGATGCGAGAAAAAGGAATCA
AACTGCTGCAGGCCCAGAAGTTGGTGCAGTACTTACGAGAATGTGAGGACGTGATGGACTGGATCAATGACAAGGAAGCAATTGTTACTT
CTGAAGAGCTGGGCCAGGATCTGGAGCATGTAGAGGTTTTACAGAAGAAATTTGAAGAGTTTCAAACAGATATGGCTGCTCATGAAGAAA
GAGTTAATGAAGTGAACCAGTTTGCTGCCAAACTCATACAGGAGCAGCACCCTGAGGAGGAACTGATCAAGACTAAGCAGGATGAAGTCA
ATGCAGCCTGGCAGCGGCTGAAGGGCCTGGCTCTGCAGAGGCAGGGGAAGCTCTTTGGGGCAGCAGAAGTTCAGCGCTTTAACAGGGATG
TGGATGAGACTATCAGTTGGATTAAGGAAAAGGAGCAGTTAATGGCCTCTGATGATTTTGGCCGAGACCTGGCAAGTGTTCAGGCTCTGC
TTCGGAAGCACGAGGGTCTGGAGAGAGATCTTGCTGCTCTAGAAGACAAGGTCAAAGCCCTGTGTGCTGAGGCTGACCGCCTGCAACAGT
CCCACCCTCTGAGTGCAACACAGATTCAAGTGAAGCGAGAGGAACTGATTACAAACTGGGAGCAGATCCGCACCTTGGCGGCAGAGAGAC
ATGCACGGCTCAATGATTCATACAGGCTTCAACGCTTCCTTGCTGACTTCCGTGACCTCACCAGCTGGGTGACTGAGATGAAAGCCCTCA
TCAATGCAGATGAGCTTGCCAGTGATGTGGCTGGGGCTGAAGCCCTGCTAGATAGACACCAAGAGCACAAGGGTGAGCGAGAGTTACTTC
AGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCATCC
TGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGCAAG
AGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGGAGG
TGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGAAGA
AGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCGTCC
AGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGCATC
AGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGGAAT
GCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCCAGA
GAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGAGCC
ACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGAAAG
AGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCCGGC
AGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGATGC
AGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGAAGG
AGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGGTAG
GTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGCTGA
AGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAACAGC
AGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGGAGC
GTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGGAGG
AGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGGAGC
ATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGCGGG
CAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTGCCC
TGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGGATG
CCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGACCAGGATCTCCGATACCAGGAGGATG
TGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGGCCC
AGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTGTAA
GGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTACCCC
ACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTACAGG
CAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCAGTG
TCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGGAGC
TCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTGTGC
AGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGCAGC
AAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAGAAC
GGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCCACGGCTTCTTCACCCACACAGCAGG
ATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGGAGC
GGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCACCACAGCCTCTCACACTCACTTCTTG
CCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAGGGC
CAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGAGCACACAGACAGAAGACTGTGTCAT
GGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTGTTC
CCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGGAAT
CACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTCCTAGCACTTCACCACCTCCTTCATC

>86097_86097_6_SPTAN1-CEP250_SPTAN1_chr9_131340524_ENST00000372739_CEP250_chr20_34090217_ENST00000397527_length(amino acids)=1543AA_BP=441
MRSERCGAEAAEAPRSFSTPRPDAPTPLTPREPKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEEL
EKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL
QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA
WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP
LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGERELLQAA
KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET
LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL
ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST
VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER
AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ
SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL
GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG
KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV
QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL
RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG
EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGR
GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL

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Fusion Gene PPI Analysis for SPTAN1-CEP250


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPTAN1-CEP250


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPTAN1-CEP250


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource