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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AZIN1-YME1L1 (FusionGDB2 ID:8610)

Fusion Gene Summary for AZIN1-YME1L1

Fusion gene summary

Fusion gene information	Fusion gene name: AZIN1-YME1L1
	Fusion gene ID: 8610
		Hgene	Tgene
	Gene symbol	AZIN1	YME1L1
	Gene ID	51582	10730
	Gene name	antizyme inhibitor 1	YME1 like 1 ATPase
	Synonyms	AZI\|AZI1\|AZIA1\|OAZI\|OAZIN\|ODC1L	FTSH\|MEG4\|OPA11\|PAMP\|YME1L
	Cytomap	8q22.3	10p12.1
	Type of gene	protein-coding	protein-coding
	Description	antizyme inhibitor 1ornithine decarboxylase antizyme inhibitor	ATP-dependent zinc metalloprotease YME1L1ATP-dependent metalloprotease FtsH1 homologYME1-like protein 1meg-4presenilin-associated metalloprotease
	Modification date	20200313	20200313
	UniProtAcc	O14977	.
	Ensembl transtripts involved in fusion gene	ENST00000337198, ENST00000347770, ENST00000522311,	ENST00000463270, ENST00000477432, ENST00000326799, ENST00000375972, ENST00000376016,
Fusion gene scores	* DoF score	18 X 12 X 9=1944	5 X 4 X 4=80
	# samples	19	5
	** MAII score	log2(19/1944*10)=-3.35495689527483 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AZIN1 [Title/Abstract] AND YME1L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AZIN1(103851878)-YME1L1(27412628), # samples:1
Anticipated loss of major functional domain due to fusion event.	AZIN1-YME1L1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. AZIN1-YME1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. AZIN1-YME1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AZIN1	GO:0042177	negative regulation of protein catabolic process	17900240
Hgene	AZIN1	GO:1902269	positive regulation of polyamine transmembrane transport	18508777
Tgene	YME1L1	GO:0034214	protein hexamerization	27786171

Fusion gene breakpoints across AZIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across YME1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A09D-01A	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-

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Fusion Gene ORF analysis for AZIN1-YME1L1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000337198	ENST00000463270	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5CDS-5UTR	ENST00000347770	ENST00000463270	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5CDS-intron	ENST00000337198	ENST00000477432	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5CDS-intron	ENST00000347770	ENST00000477432	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5UTR-3CDS	ENST00000522311	ENST00000326799	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5UTR-3CDS	ENST00000522311	ENST00000375972	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5UTR-3CDS	ENST00000522311	ENST00000376016	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5UTR-5UTR	ENST00000522311	ENST00000463270	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
5UTR-intron	ENST00000522311	ENST00000477432	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
Frame-shift	ENST00000337198	ENST00000326799	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
Frame-shift	ENST00000337198	ENST00000375972	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
Frame-shift	ENST00000337198	ENST00000376016	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
In-frame	ENST00000347770	ENST00000326799	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
In-frame	ENST00000347770	ENST00000375972	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-
In-frame	ENST00000347770	ENST00000376016	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000347770	AZIN1	chr8	103851878	-	ENST00000326799	YME1L1	chr10	27412628	-	3767	1042	1152	2243	363
ENST00000347770	AZIN1	chr8	103851878	-	ENST00000376016	YME1L1	chr10	27412628	-	3767	1042	1152	2243	363
ENST00000347770	AZIN1	chr8	103851878	-	ENST00000375972	YME1L1	chr10	27412628	-	2487	1042	1152	2243	363

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000347770	ENST00000326799	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-	0.000317374	0.99968266
ENST00000347770	ENST00000376016	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-	0.000317374	0.99968266
ENST00000347770	ENST00000375972	AZIN1	chr8	103851878	-	YME1L1	chr10	27412628	-	0.000391559	0.99960846

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Fusion Genomic Features for AZIN1-YME1L1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AZIN1-YME1L1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:103851878/chr10:27412628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AZIN1 O14977	.
FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). {ECO:0000269\|PubMed:17900240, ECO:0000269\|PubMed:26305948}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000326799

379_386

373

774.0

Nucleotide binding

ATP

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000375972

379_386

283

684.0

Nucleotide binding

ATP

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000376016

379_386

316

717.0

Nucleotide binding

ATP

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000375972

317_773

283

684.0

Topological domain

Mitochondrial intermembrane

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000376016

317_773

316

717.0

Topological domain

Mitochondrial intermembrane

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000375972

296_316

283

684.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000326799

1_295

373

774.0

Topological domain

Mitochondrial matrix

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000326799

317_773

373

774.0

Topological domain

Mitochondrial intermembrane

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000375972

1_295

283

684.0

Topological domain

Mitochondrial matrix

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000376016

1_295

316

717.0

Topological domain

Mitochondrial matrix

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000326799

296_316

373

774.0

Transmembrane

Helical

Tgene

YME1L1

chr8:103851878

chr10:27412628

ENST00000376016

296_316

316

717.0

Transmembrane

Helical

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Fusion Gene Sequence for AZIN1-YME1L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8610_8610_1_AZIN1-YME1L1_AZIN1_chr8_103851878_ENST00000347770_YME1L1_chr10_27412628_ENST00000326799_length(transcript)=3767nt_BP=1042nt
AAATACTGGCGTCGCTGGCGCCGCCTTCTCACACTTTCAGGCTCTGATCGCGGCCGCAGTTTTTCCTTTTTTCTTCTGCCGTCGCCTTCT
CTGCCTCTTCTCATCCTTTCTCGCTCTGCTGCTCTGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCGCCTTTCTTCTTTTG
CCTGCGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCACACAGCTGGTGTCGGTGCCGCGCTTTTACCCCCAAGTCGTTCCC
GCAGCCTATGGCCCAGGCCGCCTTGGGTATTTCTGCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGACGCTTT
ACCCGACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAGTATACAACTACCCAGAGGGCCTAGGAGAAGTGCTGTATAGAGAG
CAGTTCGACTTCAACGCTGAGCCACCTTGGGAACCTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATGGAGGTCTTCACTTC
AGAAATCCAAGACTCATATTCATCCAGCTTGGTGTCAAGTGGGCTGTTGCTGCCAGAATTATCTTGTGATTATTTGAGAGATGTATCAGT
TTCTTCTGAAGTACAATCAACTGTAGAAGCCTTTGTAGCAGTTTGTTGCATATTCTAAGGACCCAGACATAGGCTTGGTGGCCCGTCTCT
TGTCTTTCCTGGTTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGGATTTATTGATGATGCAAACTACTCCGTTGGCCTGTT
GGATGAAGGAACAAACCTTGGAAATGTTATTGATAACTATGTTTATGAACATACCCTGACAGGGAAAAATGCATTTTTTGTGGGAGATCT
TGGAAAGATTGTGAAGAAACACAGTCAATGGCAGAATGTAGTGGCTCAGATAAAGCCATTCTACACAGTGAAGTGCAACTCTGCTCCAGC
TGTACTTGAGATTTTGGCAGCTCTTGGAACCGGATTTGCTTGTTCCAGTAAAGAATTCTTTTAGTTGGACCCCCAGGGACTGGAAAGACA
CTTCTTGCCCGAGCTGTGGCGGGAGAAGCTGATGTTCCTTTTTATTATGCTTCTGGATCCGAATTTGATGAGATGTTTGTGGGTGTGGGA
GCCAGCCGTATCAGAAATCTTTTTAGGGAAGCAAAGGCGAATGCTCCTTGTGTTATATTTATTGATGAATTAGATTCTGTTGGTGGGAAG
AGAATTGAATCTCCAATGCATCCATATTCAAGGCAGACCATAAATCAACTTCTTGCTGAAATGGATGGTTTTAAACCCAATGAAGGAGTT
ATCATAATAGGAGCCACAAACTTCCCAGAGGCATTAGATAATGCCTTAATACGTCCTGGTCGTTTTGACATGCAAGTTACAGTTCCAAGG
CCAGATGTAAAAGGTCGAACAGAAATTTTGAAATGGTATCTCAATAAAATAAAGTTTGATCAATCCGTTGATCCAGAAATTATAGCTCGA
GGTACTGTTGGCTTTTCCGGAGCAGAGTTGGAGAATCTTGTGAACCAGGCTGCATTAAAAGCAGCTGTTGATGGAAAAGAAATGGTTACC
ATGAAGGAGCTGGAGTTTTCCAAAGACAAAATTCTAATGGGGCCTGAAAGAAGAAGTGTGGAAATTGATAACAAAAACAAAACCATCACA
GCATATCATGAATCTGGTCATGCCATTATTGCATATTACACAAAAGATGCAATGCCTATCAACAAAGCTACAATCATGCCACGGGGGCCA
ACACTTGGACATGTGTCCCTGTTACCTGAGAATGACAGATGGAATGAAACTAGAGCCCAGCTGCTTGCACAAATGGATGTTAGTATGGGA
GGAAGAGTGGCAGAGGAGCTTATATTTGGAACCGACCATATTACAACAGGTGCTTCCAGTGATTTTGATAATGCCACTAAAATAGCAAAG
CGGATGGTTACCAAATTTGGAATGAGTGAAAAGCTTGGAGTTATGACCTACAGTGATACAGGGAAACTAAGTCCAGAAACCCAATCTGCC
ATCGAACAAGAAATAAGAATCCTTCTAAGGGACTCATATGAACGAGCAAAACATATCTTGAAAACTCATGCAAAGGAGCATAAGAATCTC
GCAGAAGCTTTATTGACCTATGAGACTTTGGATGCCAAAGAGATTCAAATTGTTCTTGAGGGGAAAAAGTTGGAAGTGAGATGATAACTC
TCTTGATATGGATGCTTGCTGGTTTTATTGCAAGAATACAAGTAGCATTGCAGTAGTCTACTTTTACAACGCTTTCCCCTCATTCTTGAT
GTGGTGTAATTGAAGGGTGTGAAATGCTTTGTCAATCATTTGTCACATTTATCCAGTTTGGGTTATTCTCATTATGACACCTATTGCAAA
TTAGCATCCCATGGCAAATATATTTTGAAAAAATAAAGAACTATCAGGATTGAAAACAGCTCTTTTGAGGAATGTCAATTAGTTATTAAG
TTGAAAGTAATTAATGATTTTATGTTTGGTTACTCTACTAGATTTGATAAAAATTGTGCCTTTAGCCTTCTATATACATCAGTGGAAACT
TAAGATGCAGTAATTATGTTCCAGATTGACCATGAATAAAATATTTTTTAATCTAAATGTAGAGAAGTTGGGATTAAAAGCAGTCTCGGA
AACACAGAGCCAGGAATATAGCCTTTTGGCATGGTGCCATGGCTCACATCTGTAATCCCAGCACTTTTGGAGGCTGAGGCGGGTGGATTG
CTTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACGTGGTGAAACGCTGTCTCTACTAAAATACAAAAAAATAGGGCTGGGCGCGGTTGC
TCACGCCTGTAATCCCAGCACTTTTCAGAGGCCAAGGCGGGCAAATCACCTGAGGTCAAGAGTTTGAGACCAGCCTGGCCAACATGGTGA
AACCCCATCTCTACTAAACATGCAAAAATTACCTGGGCATGGTGGCAGGTGCTTATAATCCCAGCTACTCTGGGGGCCAAGGCAGGAGAA
TTGCTTGAGCCTGGGAGATGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGCCTCAAA
AAAAAATTAAAATAAATTTAAATACAAAAAAAAATAGCCAGGTGTGGGGTGCATGCCTGGAATCCCAGCTACTTGAGAGGCTGAGGCACG
AGAATTGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCACAGGAGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCT
GTCTCAAAAAAAAATTAAATAAATTATTATAACCTTTCAGAAATGCTGTGTGCATTTTCATGTTCTTTTTTTTAGCATTACTGTCACTCT
CCCTAATGAAATGTACTTCAGAGAAGCAGTATTTTGTTAAATAAATACATAACCTCATTCTGAATAATGTCCCTCATTTTGACTATAACT
GTGCTTGGTTTCAAAAGCAAAATTAAACAAAAATCTCAGTCCCCTCCGAAGTGAACTTTGTGTTACCCTGCGTCAGAAATGCCAAGTTGT
GTTTACTTTTCATTCAGATTTTGTGAATATGAACATGCTGTTATAGGATCTACAGATGAATATTTAACTCAATAGAAAAATTATTTTAGA

>8610_8610_1_AZIN1-YME1L1_AZIN1_chr8_103851878_ENST00000347770_YME1L1_chr10_27412628_ENST00000326799_length(amino acids)=363AA_BP=
MFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDM
QVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDN
KNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDN
ATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKL

--------------------------------------------------------------
>8610_8610_2_AZIN1-YME1L1_AZIN1_chr8_103851878_ENST00000347770_YME1L1_chr10_27412628_ENST00000375972_length(transcript)=2487nt_BP=1042nt
AAATACTGGCGTCGCTGGCGCCGCCTTCTCACACTTTCAGGCTCTGATCGCGGCCGCAGTTTTTCCTTTTTTCTTCTGCCGTCGCCTTCT
CTGCCTCTTCTCATCCTTTCTCGCTCTGCTGCTCTGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCGCCTTTCTTCTTTTG
CCTGCGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCACACAGCTGGTGTCGGTGCCGCGCTTTTACCCCCAAGTCGTTCCC
GCAGCCTATGGCCCAGGCCGCCTTGGGTATTTCTGCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGACGCTTT
ACCCGACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAGTATACAACTACCCAGAGGGCCTAGGAGAAGTGCTGTATAGAGAG
CAGTTCGACTTCAACGCTGAGCCACCTTGGGAACCTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATGGAGGTCTTCACTTC
AGAAATCCAAGACTCATATTCATCCAGCTTGGTGTCAAGTGGGCTGTTGCTGCCAGAATTATCTTGTGATTATTTGAGAGATGTATCAGT
TTCTTCTGAAGTACAATCAACTGTAGAAGCCTTTGTAGCAGTTTGTTGCATATTCTAAGGACCCAGACATAGGCTTGGTGGCCCGTCTCT
TGTCTTTCCTGGTTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGGATTTATTGATGATGCAAACTACTCCGTTGGCCTGTT
GGATGAAGGAACAAACCTTGGAAATGTTATTGATAACTATGTTTATGAACATACCCTGACAGGGAAAAATGCATTTTTTGTGGGAGATCT
TGGAAAGATTGTGAAGAAACACAGTCAATGGCAGAATGTAGTGGCTCAGATAAAGCCATTCTACACAGTGAAGTGCAACTCTGCTCCAGC
TGTACTTGAGATTTTGGCAGCTCTTGGAACCGGATTTGCTTGTTCCAGTAAAGAATTCTTTTAGTTGGACCCCCAGGGACTGGAAAGACA
CTTCTTGCCCGAGCTGTGGCGGGAGAAGCTGATGTTCCTTTTTATTATGCTTCTGGATCCGAATTTGATGAGATGTTTGTGGGTGTGGGA
GCCAGCCGTATCAGAAATCTTTTTAGGGAAGCAAAGGCGAATGCTCCTTGTGTTATATTTATTGATGAATTAGATTCTGTTGGTGGGAAG
AGAATTGAATCTCCAATGCATCCATATTCAAGGCAGACCATAAATCAACTTCTTGCTGAAATGGATGGTTTTAAACCCAATGAAGGAGTT
ATCATAATAGGAGCCACAAACTTCCCAGAGGCATTAGATAATGCCTTAATACGTCCTGGTCGTTTTGACATGCAAGTTACAGTTCCAAGG
CCAGATGTAAAAGGTCGAACAGAAATTTTGAAATGGTATCTCAATAAAATAAAGTTTGATCAATCCGTTGATCCAGAAATTATAGCTCGA
GGTACTGTTGGCTTTTCCGGAGCAGAGTTGGAGAATCTTGTGAACCAGGCTGCATTAAAAGCAGCTGTTGATGGAAAAGAAATGGTTACC
ATGAAGGAGCTGGAGTTTTCCAAAGACAAAATTCTAATGGGGCCTGAAAGAAGAAGTGTGGAAATTGATAACAAAAACAAAACCATCACA
GCATATCATGAATCTGGTCATGCCATTATTGCATATTACACAAAAGATGCAATGCCTATCAACAAAGCTACAATCATGCCACGGGGGCCA
ACACTTGGACATGTGTCCCTGTTACCTGAGAATGACAGATGGAATGAAACTAGAGCCCAGCTGCTTGCACAAATGGATGTTAGTATGGGA
GGAAGAGTGGCAGAGGAGCTTATATTTGGAACCGACCATATTACAACAGGTGCTTCCAGTGATTTTGATAATGCCACTAAAATAGCAAAG
CGGATGGTTACCAAATTTGGAATGAGTGAAAAGCTTGGAGTTATGACCTACAGTGATACAGGGAAACTAAGTCCAGAAACCCAATCTGCC
ATCGAACAAGAAATAAGAATCCTTCTAAGGGACTCATATGAACGAGCAAAACATATCTTGAAAACTCATGCAAAGGAGCATAAGAATCTC
GCAGAAGCTTTATTGACCTATGAGACTTTGGATGCCAAAGAGATTCAAATTGTTCTTGAGGGGAAAAAGTTGGAAGTGAGATGATAACTC
TCTTGATATGGATGCTTGCTGGTTTTATTGCAAGAATACAAGTAGCATTGCAGTAGTCTACTTTTACAACGCTTTCCCCTCATTCTTGAT
GTGGTGTAATTGAAGGGTGTGAAATGCTTTGTCAATCATTTGTCACATTTATCCAGTTTGGGTTATTCTCATTATGACACCTATTGCAAA

>8610_8610_2_AZIN1-YME1L1_AZIN1_chr8_103851878_ENST00000347770_YME1L1_chr10_27412628_ENST00000375972_length(amino acids)=363AA_BP=
MFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDM
QVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDN
KNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDN
ATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKL

--------------------------------------------------------------
>8610_8610_3_AZIN1-YME1L1_AZIN1_chr8_103851878_ENST00000347770_YME1L1_chr10_27412628_ENST00000376016_length(transcript)=3767nt_BP=1042nt
AAATACTGGCGTCGCTGGCGCCGCCTTCTCACACTTTCAGGCTCTGATCGCGGCCGCAGTTTTTCCTTTTTTCTTCTGCCGTCGCCTTCT
CTGCCTCTTCTCATCCTTTCTCGCTCTGCTGCTCTGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCGCCTTTCTTCTTTTG
CCTGCGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCACACAGCTGGTGTCGGTGCCGCGCTTTTACCCCCAAGTCGTTCCC
GCAGCCTATGGCCCAGGCCGCCTTGGGTATTTCTGCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGACGCTTT
ACCCGACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAGTATACAACTACCCAGAGGGCCTAGGAGAAGTGCTGTATAGAGAG
CAGTTCGACTTCAACGCTGAGCCACCTTGGGAACCTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATGGAGGTCTTCACTTC
AGAAATCCAAGACTCATATTCATCCAGCTTGGTGTCAAGTGGGCTGTTGCTGCCAGAATTATCTTGTGATTATTTGAGAGATGTATCAGT
TTCTTCTGAAGTACAATCAACTGTAGAAGCCTTTGTAGCAGTTTGTTGCATATTCTAAGGACCCAGACATAGGCTTGGTGGCCCGTCTCT
TGTCTTTCCTGGTTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGGATTTATTGATGATGCAAACTACTCCGTTGGCCTGTT
GGATGAAGGAACAAACCTTGGAAATGTTATTGATAACTATGTTTATGAACATACCCTGACAGGGAAAAATGCATTTTTTGTGGGAGATCT
TGGAAAGATTGTGAAGAAACACAGTCAATGGCAGAATGTAGTGGCTCAGATAAAGCCATTCTACACAGTGAAGTGCAACTCTGCTCCAGC
TGTACTTGAGATTTTGGCAGCTCTTGGAACCGGATTTGCTTGTTCCAGTAAAGAATTCTTTTAGTTGGACCCCCAGGGACTGGAAAGACA
CTTCTTGCCCGAGCTGTGGCGGGAGAAGCTGATGTTCCTTTTTATTATGCTTCTGGATCCGAATTTGATGAGATGTTTGTGGGTGTGGGA
GCCAGCCGTATCAGAAATCTTTTTAGGGAAGCAAAGGCGAATGCTCCTTGTGTTATATTTATTGATGAATTAGATTCTGTTGGTGGGAAG
AGAATTGAATCTCCAATGCATCCATATTCAAGGCAGACCATAAATCAACTTCTTGCTGAAATGGATGGTTTTAAACCCAATGAAGGAGTT
ATCATAATAGGAGCCACAAACTTCCCAGAGGCATTAGATAATGCCTTAATACGTCCTGGTCGTTTTGACATGCAAGTTACAGTTCCAAGG
CCAGATGTAAAAGGTCGAACAGAAATTTTGAAATGGTATCTCAATAAAATAAAGTTTGATCAATCCGTTGATCCAGAAATTATAGCTCGA
GGTACTGTTGGCTTTTCCGGAGCAGAGTTGGAGAATCTTGTGAACCAGGCTGCATTAAAAGCAGCTGTTGATGGAAAAGAAATGGTTACC
ATGAAGGAGCTGGAGTTTTCCAAAGACAAAATTCTAATGGGGCCTGAAAGAAGAAGTGTGGAAATTGATAACAAAAACAAAACCATCACA
GCATATCATGAATCTGGTCATGCCATTATTGCATATTACACAAAAGATGCAATGCCTATCAACAAAGCTACAATCATGCCACGGGGGCCA
ACACTTGGACATGTGTCCCTGTTACCTGAGAATGACAGATGGAATGAAACTAGAGCCCAGCTGCTTGCACAAATGGATGTTAGTATGGGA
GGAAGAGTGGCAGAGGAGCTTATATTTGGAACCGACCATATTACAACAGGTGCTTCCAGTGATTTTGATAATGCCACTAAAATAGCAAAG
CGGATGGTTACCAAATTTGGAATGAGTGAAAAGCTTGGAGTTATGACCTACAGTGATACAGGGAAACTAAGTCCAGAAACCCAATCTGCC
ATCGAACAAGAAATAAGAATCCTTCTAAGGGACTCATATGAACGAGCAAAACATATCTTGAAAACTCATGCAAAGGAGCATAAGAATCTC
GCAGAAGCTTTATTGACCTATGAGACTTTGGATGCCAAAGAGATTCAAATTGTTCTTGAGGGGAAAAAGTTGGAAGTGAGATGATAACTC
TCTTGATATGGATGCTTGCTGGTTTTATTGCAAGAATACAAGTAGCATTGCAGTAGTCTACTTTTACAACGCTTTCCCCTCATTCTTGAT
GTGGTGTAATTGAAGGGTGTGAAATGCTTTGTCAATCATTTGTCACATTTATCCAGTTTGGGTTATTCTCATTATGACACCTATTGCAAA
TTAGCATCCCATGGCAAATATATTTTGAAAAAATAAAGAACTATCAGGATTGAAAACAGCTCTTTTGAGGAATGTCAATTAGTTATTAAG
TTGAAAGTAATTAATGATTTTATGTTTGGTTACTCTACTAGATTTGATAAAAATTGTGCCTTTAGCCTTCTATATACATCAGTGGAAACT
TAAGATGCAGTAATTATGTTCCAGATTGACCATGAATAAAATATTTTTTAATCTAAATGTAGAGAAGTTGGGATTAAAAGCAGTCTCGGA
AACACAGAGCCAGGAATATAGCCTTTTGGCATGGTGCCATGGCTCACATCTGTAATCCCAGCACTTTTGGAGGCTGAGGCGGGTGGATTG
CTTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACGTGGTGAAACGCTGTCTCTACTAAAATACAAAAAAATAGGGCTGGGCGCGGTTGC
TCACGCCTGTAATCCCAGCACTTTTCAGAGGCCAAGGCGGGCAAATCACCTGAGGTCAAGAGTTTGAGACCAGCCTGGCCAACATGGTGA
AACCCCATCTCTACTAAACATGCAAAAATTACCTGGGCATGGTGGCAGGTGCTTATAATCCCAGCTACTCTGGGGGCCAAGGCAGGAGAA
TTGCTTGAGCCTGGGAGATGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGCCTCAAA
AAAAAATTAAAATAAATTTAAATACAAAAAAAAATAGCCAGGTGTGGGGTGCATGCCTGGAATCCCAGCTACTTGAGAGGCTGAGGCACG
AGAATTGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCACAGGAGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCT
GTCTCAAAAAAAAATTAAATAAATTATTATAACCTTTCAGAAATGCTGTGTGCATTTTCATGTTCTTTTTTTTAGCATTACTGTCACTCT
CCCTAATGAAATGTACTTCAGAGAAGCAGTATTTTGTTAAATAAATACATAACCTCATTCTGAATAATGTCCCTCATTTTGACTATAACT
GTGCTTGGTTTCAAAAGCAAAATTAAACAAAAATCTCAGTCCCCTCCGAAGTGAACTTTGTGTTACCCTGCGTCAGAAATGCCAAGTTGT
GTTTACTTTTCATTCAGATTTTGTGAATATGAACATGCTGTTATAGGATCTACAGATGAATATTTAACTCAATAGAAAAATTATTTTAGA

>8610_8610_3_AZIN1-YME1L1_AZIN1_chr8_103851878_ENST00000347770_YME1L1_chr10_27412628_ENST00000376016_length(amino acids)=363AA_BP=
MFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDM
QVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDN
KNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDN
ATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AZIN1-YME1L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AZIN1-YME1L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AZIN1-YME1L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source