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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPTBN1-RTN4 (FusionGDB2 ID:86137)

Fusion Gene Summary for SPTBN1-RTN4

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTBN1-RTN4
Fusion gene ID: 86137
HgeneTgene
Gene symbol

SPTBN1

RTN4

Gene ID

6711

57142

Gene namespectrin beta, non-erythrocytic 1reticulon 4
SynonymsELF|HEL102|SPTB2|betaSpIIASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
Cytomap

2p16.2

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5
Modification date2020032920200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000356805, ENST00000333896, 
ENST00000354474, ENST00000402434, 
ENST00000486085, ENST00000317610, 
ENST00000337526, ENST00000357376, 
ENST00000357732, ENST00000394609, 
ENST00000394611, ENST00000404909, 
ENST00000405240, 
Fusion gene scores* DoF score24 X 20 X 9=432027 X 28 X 9=6804
# samples 2635
** MAII scorelog2(26/4320*10)=-4.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/6804*10)=-4.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTBN1 [Title/Abstract] AND RTN4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPTBN1(54753703)-RTN4(55214834), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

TgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

TgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365


check buttonFusion gene breakpoints across SPTBN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-MQ-A4LPSPTBN1chr2

54753703

+RTN4chr2

55214834

-


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Fusion Gene ORF analysis for SPTBN1-RTN4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356805ENST00000354474SPTBN1chr2

54753703

+RTN4chr2

55214834

-
5CDS-intronENST00000356805ENST00000402434SPTBN1chr2

54753703

+RTN4chr2

55214834

-
5CDS-intronENST00000356805ENST00000486085SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000317610SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000337526SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000357376SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000357732SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000394609SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000394611SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000404909SPTBN1chr2

54753703

+RTN4chr2

55214834

-
In-frameENST00000356805ENST00000405240SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000317610SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000337526SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000357376SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000357732SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000394609SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000394611SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000404909SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-3CDSENST00000333896ENST00000405240SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-intronENST00000333896ENST00000354474SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-intronENST00000333896ENST00000402434SPTBN1chr2

54753703

+RTN4chr2

55214834

-
intron-intronENST00000333896ENST00000486085SPTBN1chr2

54753703

+RTN4chr2

55214834

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356805SPTBN1chr254753703+ENST00000394609RTN4chr255214834-1962429266994242
ENST00000356805SPTBN1chr254753703+ENST00000405240RTN4chr255214834-1962429266994242
ENST00000356805SPTBN1chr254753703+ENST00000357376RTN4chr255214834-1962429266994242
ENST00000356805SPTBN1chr254753703+ENST00000317610RTN4chr255214834-1962429266994242
ENST00000356805SPTBN1chr254753703+ENST00000357732RTN4chr255214834-1962429266994242
ENST00000356805SPTBN1chr254753703+ENST00000337526RTN4chr255214834-1962429266994242
ENST00000356805SPTBN1chr254753703+ENST00000394611RTN4chr255214834-1962429266994242
ENST00000356805SPTBN1chr254753703+ENST00000404909RTN4chr255214834-1962429266994242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356805ENST00000394609SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622
ENST00000356805ENST00000405240SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622
ENST00000356805ENST00000357376SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622
ENST00000356805ENST00000317610SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622
ENST00000356805ENST00000357732SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622
ENST00000356805ENST00000337526SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622
ENST00000356805ENST00000394611SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622
ENST00000356805ENST00000404909SPTBN1chr254753703+RTN4chr255214834-0.0008378540.9991622

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Fusion Genomic Features for SPTBN1-RTN4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPTBN1-RTN4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:54753703/chr2:55214834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRTN4chr2:54753703chr2:55214834ENST0000039460907143_14811200.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000003946090730_4711200.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST00000317610071005_1192185374.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000337526291005_119210041193.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000357376291005_1192798987.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000357732181005_1192204393.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000394609071005_119211200.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000394611291005_1192798987.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000404909291005_1192798987.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000405240291005_1192798987.0DomainReticulon
TgeneRTN4chr2:54753703chr2:55214834ENST00000317610071040_1133185374.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000317610071155_1192185374.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000337526291040_113310041193.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000337526291155_119210041193.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000357376291040_1133798987.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000357376291155_1192798987.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000357732181040_1133204393.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000357732181155_1192204393.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000394609071040_113311200.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000394609071155_119211200.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000394611291040_1133798987.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000394611291155_1192798987.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000404909291040_1133798987.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000404909291155_1192798987.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000405240291040_1133798987.0Topological domainLumenal
TgeneRTN4chr2:54753703chr2:55214834ENST00000405240291155_1192798987.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000317610071019_1039185374.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000317610071134_1154185374.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000337526291019_103910041193.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000337526291134_115410041193.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000357376291019_1039798987.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000357376291134_1154798987.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000357732181019_1039204393.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000357732181134_1154204393.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000394609071019_103911200.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000394609071134_115411200.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000394611291019_1039798987.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000394611291134_1154798987.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000404909291019_1039798987.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000404909291134_1154798987.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000405240291019_1039798987.0TransmembraneHelical
TgeneRTN4chr2:54753703chr2:55214834ENST00000405240291134_1154798987.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131173_27802156.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1312197_230702156.0DomainPH
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+13154_15802156.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236173_278492365.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2362197_2307492365.0DomainPH
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+23654_158492365.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1312_27502156.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2362_275492365.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311063_116602156.0RepeatSpectrin 8
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311170_125802156.0RepeatSpectrin 9
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311276_137602156.0RepeatSpectrin 10
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311381_148202156.0RepeatSpectrin 11
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311486_159002156.0RepeatSpectrin 12
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311592_169602156.0RepeatSpectrin 13
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311698_180102156.0RepeatSpectrin 14
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311805_190702156.0RepeatSpectrin 15
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311914_201402156.0RepeatSpectrin 16
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1312018_209702156.0RepeatSpectrin 17
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131303_41102156.0RepeatSpectrin 1
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131423_52502156.0RepeatSpectrin 2
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131530_63602156.0RepeatSpectrin 3
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131639_74202156.0RepeatSpectrin 4
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131745_84702156.0RepeatSpectrin 5
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131850_95202156.0RepeatSpectrin 6
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+131957_106002156.0RepeatSpectrin 7
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361063_1166492365.0RepeatSpectrin 8
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361170_1258492365.0RepeatSpectrin 9
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361276_1376492365.0RepeatSpectrin 10
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361381_1482492365.0RepeatSpectrin 11
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361486_1590492365.0RepeatSpectrin 12
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361592_1696492365.0RepeatSpectrin 13
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361698_1801492365.0RepeatSpectrin 14
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361805_1907492365.0RepeatSpectrin 15
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361914_2014492365.0RepeatSpectrin 16
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2362018_2097492365.0RepeatSpectrin 17
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236303_411492365.0RepeatSpectrin 1
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236423_525492365.0RepeatSpectrin 2
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236530_636492365.0RepeatSpectrin 3
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236639_742492365.0RepeatSpectrin 4
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236745_847492365.0RepeatSpectrin 5
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236850_952492365.0RepeatSpectrin 6
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+236957_1060492365.0RepeatSpectrin 7
TgeneRTN4chr2:54753703chr2:55214834ENST0000031761007143_148185374.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000003176100730_47185374.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST0000033752629143_14810041193.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000003375262930_4710041193.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST0000035737629143_148798987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000003573762930_47798987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST0000035773218143_148204393.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000003577321830_47204393.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST0000039461129143_148798987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000003946112930_47798987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST0000040490929143_148798987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000004049092930_47798987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST0000040524029143_148798987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:54753703chr2:55214834ENST000004052402930_47798987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:54753703chr2:55214834ENST00000317610071_1018185374.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000337526291_101810041193.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000357376291_1018798987.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000357732181_1018204393.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000394609071_101811200.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000394611291_1018798987.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000404909291_1018798987.0Topological domainCytoplasmic
TgeneRTN4chr2:54753703chr2:55214834ENST00000405240291_1018798987.0Topological domainCytoplasmic


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Fusion Gene Sequence for SPTBN1-RTN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86137_86137_1_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000317610_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_1_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000317610_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------
>86137_86137_2_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000337526_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_2_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000337526_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------
>86137_86137_3_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000357376_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_3_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000357376_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------
>86137_86137_4_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000357732_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_4_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000357732_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------
>86137_86137_5_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000394609_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_5_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000394609_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------
>86137_86137_6_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000394611_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_6_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000394611_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------
>86137_86137_7_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000404909_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_7_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000404909_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------
>86137_86137_8_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000405240_length(transcript)=1962nt_BP=429nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGTTGTTGACCTCCTGTACTGGA
GAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCT
ACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACC
CATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCA
CGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTG
GTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGA
TAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTG
AATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACC
TTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGC
CATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTG
GAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTGGAGCTAGAAAAAAAAAAA
AAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGTTTGTTTAGACGAGATCAT
ACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATTGCCAATATAAGT
AAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGTCA
TTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCA
CACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCA
AAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTG

>86137_86137_8_SPTBN1-RTN4_SPTBN1_chr2_54753703_ENST00000356805_RTN4_chr2_55214834_ENST00000405240_length(amino acids)=242AA_BP=54
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPTBN1-RTN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000333896+1311563_209302156.0ANK2
HgeneSPTBN1chr2:54753703chr2:55214834ENST00000356805+2361563_209349.3333333333333362365.0ANK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPTBN1-RTN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPTBN1-RTN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource