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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:SPTBN2-PRIM2 (FusionGDB2 ID:86151)

Fusion Gene Summary for SPTBN2-PRIM2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTBN2-PRIM2
Fusion gene ID: 86151
HgeneTgene
Gene symbol

SPTBN2

PRIM2

Gene ID

6712

5558

Gene namespectrin beta, non-erythrocytic 2DNA primase subunit 2
SynonymsGTRAP41|SCA5|SCAR14PRIM2A|p58
Cytomap

11q13.2

6p11.2

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 2beta-III spectringlutamate transporter EAAT4-associated protein 41spectrin beta III sigma 2spectrin beta chain, brain 2spectrin, non-erythroid beta chain 2spinocerebellar ataxia 5 proteinDNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000309996, ENST00000529997, 
ENST00000533211, 		ENST00000389488, 
ENST00000607273, 
Fusion gene scores* DoF score8 X 10 X 4=32015 X 17 X 6=1530
# samples 1123
** MAII scorelog2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/1530*10)=-2.73382588663564
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTBN2 [Title/Abstract] AND PRIM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPTBN2(66472068)-PRIM2(57467079), # samples:1
SPTBN2(66472069)-PRIM2(57467080), # samples:1
Anticipated loss of major functional domain due to fusion event.SPTBN2-PRIM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SPTBN2-PRIM2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SPTBN2-PRIM2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPTBN2

GO:0016192

vesicle-mediated transport

9826670


check buttonFusion gene breakpoints across SPTBN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRIM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A4ZE-01ASPTBN2chr11

66472069

-PRIM2chr6

57467080

+
ChimerDB4BRCATCGA-AC-A4ZESPTBN2chr11

66472068

-PRIM2chr6

57467079

+


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Fusion Gene ORF analysis for SPTBN2-PRIM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000309996ENST00000389488SPTBN2chr11

66472069

-PRIM2chr6

57467080

+
5CDS-3UTRENST00000309996ENST00000389488SPTBN2chr11

66472068

-PRIM2chr6

57467079

+
5CDS-3UTRENST00000529997ENST00000389488SPTBN2chr11

66472069

-PRIM2chr6

57467080

+
5CDS-3UTRENST00000529997ENST00000389488SPTBN2chr11

66472068

-PRIM2chr6

57467079

+
5CDS-3UTRENST00000533211ENST00000389488SPTBN2chr11

66472069

-PRIM2chr6

57467080

+
5CDS-3UTRENST00000533211ENST00000389488SPTBN2chr11

66472068

-PRIM2chr6

57467079

+
Frame-shiftENST00000533211ENST00000607273SPTBN2chr11

66472069

-PRIM2chr6

57467080

+
Frame-shiftENST00000533211ENST00000607273SPTBN2chr11

66472068

-PRIM2chr6

57467079

+
In-frameENST00000309996ENST00000607273SPTBN2chr11

66472069

-PRIM2chr6

57467080

+
In-frameENST00000309996ENST00000607273SPTBN2chr11

66472068

-PRIM2chr6

57467079

+
In-frameENST00000529997ENST00000607273SPTBN2chr11

66472069

-PRIM2chr6

57467080

+
In-frameENST00000529997ENST00000607273SPTBN2chr11

66472068

-PRIM2chr6

57467079

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309996SPTBN2chr1166472068-ENST00000607273PRIM2chr657467079+3933275032834943
ENST00000529997SPTBN2chr1166472068-ENST00000607273PRIM2chr657467079+3861267802762920
ENST00000309996SPTBN2chr1166472069-ENST00000607273PRIM2chr657467080+3933275032834943
ENST00000529997SPTBN2chr1166472069-ENST00000607273PRIM2chr657467080+3861267802762920

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309996ENST00000607273SPTBN2chr1166472068-PRIM2chr657467079+0.0068423390.9931577
ENST00000529997ENST00000607273SPTBN2chr1166472068-PRIM2chr657467079+0.0063046050.99369544
ENST00000309996ENST00000607273SPTBN2chr1166472069-PRIM2chr657467080+0.0068423390.9931577
ENST00000529997ENST00000607273SPTBN2chr1166472069-PRIM2chr657467080+0.0063046050.99369544

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Fusion Genomic Features for SPTBN2-PRIM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPTBN2chr1166472068-PRIM2chr657467079+0.073216610.92678344
SPTBN2chr1166472068-PRIM2chr657467079+0.073216610.92678344
SPTBN2chr1166472068-PRIM2chr657467079+0.073216610.92678344
SPTBN2chr1166472068-PRIM2chr657467079+0.073216610.92678344

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SPTBN2-PRIM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:66472068/chr6:57467079)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437176_2818922391.0DomainCalponin-homology (CH) 2
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-143757_1618922391.0DomainCalponin-homology (CH) 1
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335176_2818922366.0DomainCalponin-homology (CH) 2
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-133557_1618922366.0DomainCalponin-homology (CH) 1
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538176_2818922391.0DomainCalponin-homology (CH) 2
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-153857_1618922391.0DomainCalponin-homology (CH) 1
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437176_2818922391.0DomainCalponin-homology (CH) 2
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-143757_1618922391.0DomainCalponin-homology (CH) 1
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335176_2818922366.0DomainCalponin-homology (CH) 2
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-133557_1618922366.0DomainCalponin-homology (CH) 1
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538176_2818922391.0DomainCalponin-homology (CH) 2
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-153857_1618922391.0DomainCalponin-homology (CH) 1
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14372_2788922391.0RegionNote=Actin-binding
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13352_2788922366.0RegionNote=Actin-binding
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15382_2788922391.0RegionNote=Actin-binding
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14372_2788922391.0RegionNote=Actin-binding
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13352_2788922366.0RegionNote=Actin-binding
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15382_2788922391.0RegionNote=Actin-binding
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437306_4148922391.0RepeatSpectrin 1
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437427_5278922391.0RepeatSpectrin 2
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437532_6398922391.0RepeatSpectrin 3
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437642_7448922391.0RepeatSpectrin 4
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437749_8498922391.0RepeatSpectrin 5
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335306_4148922366.0RepeatSpectrin 1
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335427_5278922366.0RepeatSpectrin 2
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335532_6398922366.0RepeatSpectrin 3
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335642_7448922366.0RepeatSpectrin 4
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335749_8498922366.0RepeatSpectrin 5
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538306_4148922391.0RepeatSpectrin 1
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538427_5278922391.0RepeatSpectrin 2
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538532_6398922391.0RepeatSpectrin 3
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538642_7448922391.0RepeatSpectrin 4
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538749_8498922391.0RepeatSpectrin 5
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437306_4148922391.0RepeatSpectrin 1
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437427_5278922391.0RepeatSpectrin 2
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437532_6398922391.0RepeatSpectrin 3
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437642_7448922391.0RepeatSpectrin 4
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437749_8498922391.0RepeatSpectrin 5
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335306_4148922366.0RepeatSpectrin 1
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335427_5278922366.0RepeatSpectrin 2
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335532_6398922366.0RepeatSpectrin 3
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335642_7448922366.0RepeatSpectrin 4
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335749_8498922366.0RepeatSpectrin 5
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538306_4148922391.0RepeatSpectrin 1
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538427_5278922391.0RepeatSpectrin 2
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538532_6398922391.0RepeatSpectrin 3
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538642_7448922391.0RepeatSpectrin 4
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538749_8498922391.0RepeatSpectrin 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14372218_23288922391.0DomainPH
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13352218_23288922366.0DomainPH
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15382218_23288922391.0DomainPH
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14372218_23288922391.0DomainPH
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13352218_23288922366.0DomainPH
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15382218_23288922391.0DomainPH
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371066_11698922391.0RepeatSpectrin 8
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371174_12628922391.0RepeatSpectrin 9
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371279_13798922391.0RepeatSpectrin 10
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371384_14858922391.0RepeatSpectrin 11
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371489_15868922391.0RepeatSpectrin 12
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371589_16928922391.0RepeatSpectrin 13
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371696_17978922391.0RepeatSpectrin 14
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371801_19048922391.0RepeatSpectrin 15
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14371910_20108922391.0RepeatSpectrin 16
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-14372017_20768922391.0RepeatSpectrin 17
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437855_9548922391.0RepeatSpectrin 6
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000309996-1437960_10638922391.0RepeatSpectrin 7
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351066_11698922366.0RepeatSpectrin 8
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351174_12628922366.0RepeatSpectrin 9
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351279_13798922366.0RepeatSpectrin 10
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351384_14858922366.0RepeatSpectrin 11
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351489_15868922366.0RepeatSpectrin 12
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351589_16928922366.0RepeatSpectrin 13
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351696_17978922366.0RepeatSpectrin 14
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351801_19048922366.0RepeatSpectrin 15
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13351910_20108922366.0RepeatSpectrin 16
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-13352017_20768922366.0RepeatSpectrin 17
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335855_9548922366.0RepeatSpectrin 6
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000529997-1335960_10638922366.0RepeatSpectrin 7
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381066_11698922391.0RepeatSpectrin 8
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381174_12628922391.0RepeatSpectrin 9
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381279_13798922391.0RepeatSpectrin 10
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381384_14858922391.0RepeatSpectrin 11
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381489_15868922391.0RepeatSpectrin 12
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381589_16928922391.0RepeatSpectrin 13
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381696_17978922391.0RepeatSpectrin 14
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381801_19048922391.0RepeatSpectrin 15
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15381910_20108922391.0RepeatSpectrin 16
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-15382017_20768922391.0RepeatSpectrin 17
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538855_9548922391.0RepeatSpectrin 6
HgeneSPTBN2chr11:66472068chr6:57467079ENST00000533211-1538960_10638922391.0RepeatSpectrin 7
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371066_11698922391.0RepeatSpectrin 8
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371174_12628922391.0RepeatSpectrin 9
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371279_13798922391.0RepeatSpectrin 10
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371384_14858922391.0RepeatSpectrin 11
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371489_15868922391.0RepeatSpectrin 12
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371589_16928922391.0RepeatSpectrin 13
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371696_17978922391.0RepeatSpectrin 14
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371801_19048922391.0RepeatSpectrin 15
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14371910_20108922391.0RepeatSpectrin 16
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-14372017_20768922391.0RepeatSpectrin 17
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437855_9548922391.0RepeatSpectrin 6
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000309996-1437960_10638922391.0RepeatSpectrin 7
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351066_11698922366.0RepeatSpectrin 8
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351174_12628922366.0RepeatSpectrin 9
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351279_13798922366.0RepeatSpectrin 10
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351384_14858922366.0RepeatSpectrin 11
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351489_15868922366.0RepeatSpectrin 12
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351589_16928922366.0RepeatSpectrin 13
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351696_17978922366.0RepeatSpectrin 14
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351801_19048922366.0RepeatSpectrin 15
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13351910_20108922366.0RepeatSpectrin 16
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-13352017_20768922366.0RepeatSpectrin 17
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335855_9548922366.0RepeatSpectrin 6
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000529997-1335960_10638922366.0RepeatSpectrin 7
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381066_11698922391.0RepeatSpectrin 8
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381174_12628922391.0RepeatSpectrin 9
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381279_13798922391.0RepeatSpectrin 10
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381384_14858922391.0RepeatSpectrin 11
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381489_15868922391.0RepeatSpectrin 12
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381589_16928922391.0RepeatSpectrin 13
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381696_17978922391.0RepeatSpectrin 14
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381801_19048922391.0RepeatSpectrin 15
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15381910_20108922391.0RepeatSpectrin 16
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-15382017_20768922391.0RepeatSpectrin 17
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538855_9548922391.0RepeatSpectrin 6
HgeneSPTBN2chr11:66472069chr6:57467080ENST00000533211-1538960_10638922391.0RepeatSpectrin 7


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Fusion Gene Sequence for SPTBN2-PRIM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86151_86151_1_SPTBN2-PRIM2_SPTBN2_chr11_66472068_ENST00000309996_PRIM2_chr6_57467079_ENST00000607273_length(transcript)=3933nt_BP=2750nt
CCACTGAGCAGCCAACCGCAGCCTCTGGCCACAAGGAGAGCGGAGCACAGGAGCAGGAAGCCGCCTACCACCATGAGCAGCACGCTGTCA
CCCACAGACTTTGACAGCTTGGAAATCCAGGGCCAGTACAGTGACATCAACAACCGCTGGGACCTTCCTGACTCGGACTGGGACAATGAC
AGCAGCTCGGCCCGCCTCTTTGAGAGGTCTCGCATTAAGGCTCTGGCAGATGAACGAGAAGCTGTGCAGAAGAAAACCTTCACCAAGTGG
GTAAACTCGCACCTGGCCCGGGTCACGTGCCGGGTGGGGGACCTGTACAGCGACCTCCGGGACGGACGCAACCTGCTGAGGCTCCTCGAG
GTGCTCTCGGGAGAGATACTGCCAAAGCCTACAAAGGGCCGCATGCGGATCCACTGCCTGGAGAACGTGGACAAGGCACTGCAGTTCCTC
AAGGAGCAGAAAGTGCACTTGGAAAACATGGGCTCCCATGACATTGTGGACGGAAACCACCGACTGACCCTTGGGCTGGTCTGGACCATC
ATCCTTCGATTCCAGATCCAAGACATCAGTGTGGAGACAGAAGACAACAAGGAGAAGAAGTCAGCCAAGGATGCCCTGCTTCTGTGGTGC
CAGATGAAGACTGCAGGTTATCCCAACGTCAATGTACACAACTTCACCACCAGCTGGAGAGATGGACTAGCTTTCAACGCCATCGTGCAT
AAACACCGGCCAGACCTGCTGGATTTTGAGTCTCTGAAGAAGTGTAATGCACACTATAATCTGCAGAATGCATTCAATCTGGCTGAAAAG
GAACTGGGACTTACCAAGCTGCTGGATCCCGAAGACGTGAATGTGGACCAGCCAGATGAGAAGTCAATCATTACCTATGTGGCTACTTAC
TACCATTACTTCTCCAAGATGAAGGCCCTGGCCGTGGAAGGCAAGAGAATTGGCAAGGTGCTGGACCATGCCATGGAGGCAGAGCGCCTG
GTGGAGAAATACGAGTCCCTGGCCTCGGAGCTGCTGCAGTGGATCGAGCAAACGATCGTGACCCTCAATGACCGGCAGTTGGCCAACTCC
CTTAGCGGGGTCCAGAACCAGCTGCAGTCCTTCAACTCCTACCGCACCGTGGAGAAGCCGCCCAAGTTTACCGAGAAAGGGAACTTGGAA
GTGCTGCTCTTCACCATCCAGAGCAAGCTTCGGGCCAACAACCAGAAGGTCTACACGCCCCGCGAGGGCCGGCTCATCTCGGACATCAAC
AAGGCTTGGGAGCGGCTGGAGAAGGCGGAGCACGAGCGTGAGCTGGCCCTGCGCACCGAGCTCATCCGCCAGGAGAAGCTGGAGCAGCTG
GCCGCCCGCTTCGACCGCAAGGCTGCCATGCGGGAGACCTGGCTCAGCGAGAACCAGCGCCTCGTGTCCCAGGACAACTTTGGGCTGGAG
CTGGCAGCTGTCGAGGCAGCAGTACGGAAGCACGAAGCCATTGAGACGGACATCGTGGCCTACAGCGGCCGGGTGCAGGCAGTGGACGCC
GTGGCTGCAGAGCTGGCCGCCGAGCGCTACCACGACATCAAGCGCATCGCCGCTCGGCAGCACAACGTGGCACGGCTCTGGGACTTCTTG
CGGCAGATGGTGGCCGCCCGGCGGGAGCGGCTCCTCCTCAACCTGGAGCTGCAGAAGGTGTTCCAGGACCTGCTCTACCTCATGGACTGG
ATGGAAGAGATGAAGGGCCGGCTGCAGTCTCAGGACCTGGGCAGGCACCTAGCAGGAGTGGAGGACCTGCTGCAGCTGCACGAGCTGGTG
GAGGCAGACATCGCCGTGCAGGCCGAGAGGGTGCGGGCCGTCAGCGCCTCTGCCCTGCGCTTCTGCAACCCAGGGAAAGAGTATAGACCT
TGCGACCCGCAGCTGGTGTCGGAGCGGGTGGCCAAGCTAGAGCAGAGCTATGAGGCACTGTGCGAGTTGGCAGCGGCGCGGCGGGCCCGG
CTGGAGGAATCACGGCGGCTCTGGCGTTTCCTCTGGGAGGTGGGTGAAGCTGAGGCCTGGGTGCGGGAGCAGCAGCACCTCCTGGCCTCA
GCCGACACGGGCCGAGACCTGACCGGTGCCCTCCGCCTGCTCAACAAGCACACAGCCCTGCGGGGCGAGATGAGCGGCCGGCTGGGGCCC
CTGAAGCTCACCCTGGAGCAGGGCCAGCAGTTGGTGGCCGAGGGTCACCCTGGGGCAAGCCAGGCCTCTGCCCGTGCAGCTGAACTCCAA
GCCCAGTGGGAGCGGCTAGAGGCCCTGGCCGAGGAGCGTGCCCAGCGGCTGGCCCAAGCCGCCAGCCTCTACCAGTTCCAGGCCGATGCA
AACGACATGGAGGCCTGGTTGGTTGACGCACTGCGCCTGGTGTCCAGCCCCGAGCTGGGGCACGACGAGTTCTCCACGCAGGCTCTAGCC
AGGCAGCATCGGGCCCTGGAGGAGGAGATTCGAAGCCACCGGCCAACCCTGGACGCCTTGAGGGAACAGGCAGCAGCCCTGCCCCCCACA
CTGAGCCGCACGCCCGAGGTGCAGAGCCGGGTGCCCACCCTGGAGCGGCACTACGAGGAGCTGCAGGCCCGGGCAGGCGAGCGAGCGCGG
GCCTTGGAGGCAGCCCTGGCGCTCTACACCATGCTCAGCGAGGCCGGGGCCTGTGGACTCTGGGTGGAGGAGAAGGAGCAGTGGCTCAAC
GGGCTGGCCCTGCCTGAACGCCTGGAGGACCTGGAGGTCGTGCAGCAGAGTTTGATAAAGGTTACTCTTAGAACATCCGTCACAGCTTTG
GAAAGGAAGGCAAGAGGACAGACTATACACCTTTCAGTTGCCTGAAGATTATTCTATCCAATCCACCAAGCCAAGGGGATTATCATGGGT
GCCCATTCCGTCACAGTGATCCAGAGCTGCTGAAGCAAAAGTTGCAGTCATACAAGATCTCTCCTGGAGGGATAAGCCAGATTTTGGATT
TAGTAAAGGGGACACATTACCAGGTAGCCTGTCAAAAATACTTTGAGATGATACACAATGTGGGTGATTGTGGCTTTTCTTTGAATCATC
CTAATCATTTCTTTTGTGAGAGCCAACGTATTCTAAATGGTGGTAAAGACATAAAGAAGGAATCTATCCAACCAGAAACTCCTCAACCCA
AACCAAGTGTCCAGAAAACCAAGGATGCATCATCTGCTCTGGCCTCTTTAAATTCCTCTCTGGAAATGGATATGGAAGGACTAGAGGATT
ACTTTAGTGAAGATTCTTAGGCAGTTTTGTAACCCTTTTTCCTCAATAGCCTGTTTCCTGTTTTTAAGATTTTGCCTTTGTTGTTGAAAA
AGTGTTGCACTCTGTTGTGTAATTGTGACACAATTACAGCTGATTGCAGCCTCAACCTTCCCAGCTCAAGTGATCCTCCTACCTCAGCCT
CCCAAGTAGTTGGGACCACAGGTGTGCACCCCATATCCAGCTATTTTTTTTCAATTTTTTTTGTAGAGGGGGGGTCTCCCTATGTTGCCC
AGGCAGATCTCAGACTGCTGGGCTCAAGCGATCCTCACACCTCAGCCTCCCAGAGTGCTGGGATTACAGTTGTGAGCCACTGTGCCTGGC
CTTTCTTTTTTTAACCTTTTTGTTTAACTTCTCTCTTCACTGCATCCCAATCCATCTACAGGCATGCACACTTATTAGGAAAGCAGGTTT
GAGGTAACGAGACTTTCACTATATTTTGCTTTGACAGAAGGAAAGAGGAAGAGTTTCTATTAAAATCTGTCACTTGAGTGATGTCATTCA
AGTCCTATTTTAGGAGATAAAAACACCTTTGGGGACTGGTTAAAGTCCCCCAGAAACTACAATAAAGAACAACTTTTGTTTTAACTCTTA

>86151_86151_1_SPTBN2-PRIM2_SPTBN2_chr11_66472068_ENST00000309996_PRIM2_chr6_57467079_ENST00000607273_length(amino acids)=943AA_BP=915
MSSQPQPLATRRAEHRSRKPPTTMSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWV
NSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTII
LRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKE
LGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSL
SGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLA
ARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLR
QMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPC
DPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPL
KLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALAR
QHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG

--------------------------------------------------------------
>86151_86151_2_SPTBN2-PRIM2_SPTBN2_chr11_66472068_ENST00000529997_PRIM2_chr6_57467079_ENST00000607273_length(transcript)=3861nt_BP=2678nt
ATGAGCAGCACGCTGTCACCCACAGACTTTGACAGCTTGGAAATCCAGGGCCAGTACAGTGACATCAACAACCGCTGGGACCTTCCTGAC
TCGGACTGGGACAATGACAGCAGCTCGGCCCGCCTCTTTGAGAGGTCTCGCATTAAGGCTCTGGCAGATGAACGAGAAGCTGTGCAGAAG
AAAACCTTCACCAAGTGGGTAAACTCGCACCTGGCCCGGGTCACGTGCCGGGTGGGGGACCTGTACAGCGACCTCCGGGACGGACGCAAC
CTGCTGAGGCTCCTCGAGGTGCTCTCGGGAGAGATACTGCCAAAGCCTACAAAGGGCCGCATGCGGATCCACTGCCTGGAGAACGTGGAC
AAGGCACTGCAGTTCCTCAAGGAGCAGAAAGTGCACTTGGAAAACATGGGCTCCCATGACATTGTGGACGGAAACCACCGACTGACCCTT
GGGCTGGTCTGGACCATCATCCTTCGATTCCAGATCCAAGACATCAGTGTGGAGACAGAAGACAACAAGGAGAAGAAGTCAGCCAAGGAT
GCCCTGCTTCTGTGGTGCCAGATGAAGACTGCAGGTTATCCCAACGTCAATGTACACAACTTCACCACCAGCTGGAGAGATGGACTAGCT
TTCAACGCCATCGTGCATAAACACCGGCCAGACCTGCTGGATTTTGAGTCTCTGAAGAAGTGTAATGCACACTATAATCTGCAGAATGCA
TTCAATCTGGCTGAAAAGGAACTGGGACTTACCAAGCTGCTGGATCCCGAAGACGTGAATGTGGACCAGCCAGATGAGAAGTCAATCATT
ACCTATGTGGCTACTTACTACCATTACTTCTCCAAGATGAAGGCCCTGGCCGTGGAAGGCAAGAGAATTGGCAAGGTGCTGGACCATGCC
ATGGAGGCAGAGCGCCTGGTGGAGAAATACGAGTCCCTGGCCTCGGAGCTGCTGCAGTGGATCGAGCAAACGATCGTGACCCTCAATGAC
CGGCAGTTGGCCAACTCCCTTAGCGGGGTCCAGAACCAGCTGCAGTCCTTCAACTCCTACCGCACCGTGGAGAAGCCGCCCAAGTTTACC
GAGAAAGGGAACTTGGAAGTGCTGCTCTTCACCATCCAGAGCAAGCTTCGGGCCAACAACCAGAAGGTCTACACGCCCCGCGAGGGCCGG
CTCATCTCGGACATCAACAAGGCTTGGGAGCGGCTGGAGAAGGCGGAGCACGAGCGTGAGCTGGCCCTGCGCACCGAGCTCATCCGCCAG
GAGAAGCTGGAGCAGCTGGCCGCCCGCTTCGACCGCAAGGCTGCCATGCGGGAGACCTGGCTCAGCGAGAACCAGCGCCTCGTGTCCCAG
GACAACTTTGGGCTGGAGCTGGCAGCTGTCGAGGCAGCAGTACGGAAGCACGAAGCCATTGAGACGGACATCGTGGCCTACAGCGGCCGG
GTGCAGGCAGTGGACGCCGTGGCTGCAGAGCTGGCCGCCGAGCGCTACCACGACATCAAGCGCATCGCCGCTCGGCAGCACAACGTGGCA
CGGCTCTGGGACTTCTTGCGGCAGATGGTGGCCGCCCGGCGGGAGCGGCTCCTCCTCAACCTGGAGCTGCAGAAGGTGTTCCAGGACCTG
CTCTACCTCATGGACTGGATGGAAGAGATGAAGGGCCGGCTGCAGTCTCAGGACCTGGGCAGGCACCTAGCAGGAGTGGAGGACCTGCTG
CAGCTGCACGAGCTGGTGGAGGCAGACATCGCCGTGCAGGCCGAGAGGGTGCGGGCCGTCAGCGCCTCTGCCCTGCGCTTCTGCAACCCA
GGGAAAGAGTATAGACCTTGCGACCCGCAGCTGGTGTCGGAGCGGGTGGCCAAGCTAGAGCAGAGCTATGAGGCACTGTGCGAGTTGGCA
GCGGCGCGGCGGGCCCGGCTGGAGGAATCACGGCGGCTCTGGCGTTTCCTCTGGGAGGTGGGTGAAGCTGAGGCCTGGGTGCGGGAGCAG
CAGCACCTCCTGGCCTCAGCCGACACGGGCCGAGACCTGACCGGTGCCCTCCGCCTGCTCAACAAGCACACAGCCCTGCGGGGCGAGATG
AGCGGCCGGCTGGGGCCCCTGAAGCTCACCCTGGAGCAGGGCCAGCAGTTGGTGGCCGAGGGTCACCCTGGGGCAAGCCAGGCCTCTGCC
CGTGCAGCTGAACTCCAAGCCCAGTGGGAGCGGCTAGAGGCCCTGGCCGAGGAGCGTGCCCAGCGGCTGGCCCAAGCCGCCAGCCTCTAC
CAGTTCCAGGCCGATGCAAACGACATGGAGGCCTGGTTGGTTGACGCACTGCGCCTGGTGTCCAGCCCCGAGCTGGGGCACGACGAGTTC
TCCACGCAGGCTCTAGCCAGGCAGCATCGGGCCCTGGAGGAGGAGATTCGAAGCCACCGGCCAACCCTGGACGCCTTGAGGGAACAGGCA
GCAGCCCTGCCCCCCACACTGAGCCGCACGCCCGAGGTGCAGAGCCGGGTGCCCACCCTGGAGCGGCACTACGAGGAGCTGCAGGCCCGG
GCAGGCGAGCGAGCGCGGGCCTTGGAGGCAGCCCTGGCGCTCTACACCATGCTCAGCGAGGCCGGGGCCTGTGGACTCTGGGTGGAGGAG
AAGGAGCAGTGGCTCAACGGGCTGGCCCTGCCTGAACGCCTGGAGGACCTGGAGGTCGTGCAGCAGAGTTTGATAAAGGTTACTCTTAGA
ACATCCGTCACAGCTTTGGAAAGGAAGGCAAGAGGACAGACTATACACCTTTCAGTTGCCTGAAGATTATTCTATCCAATCCACCAAGCC
AAGGGGATTATCATGGGTGCCCATTCCGTCACAGTGATCCAGAGCTGCTGAAGCAAAAGTTGCAGTCATACAAGATCTCTCCTGGAGGGA
TAAGCCAGATTTTGGATTTAGTAAAGGGGACACATTACCAGGTAGCCTGTCAAAAATACTTTGAGATGATACACAATGTGGGTGATTGTG
GCTTTTCTTTGAATCATCCTAATCATTTCTTTTGTGAGAGCCAACGTATTCTAAATGGTGGTAAAGACATAAAGAAGGAATCTATCCAAC
CAGAAACTCCTCAACCCAAACCAAGTGTCCAGAAAACCAAGGATGCATCATCTGCTCTGGCCTCTTTAAATTCCTCTCTGGAAATGGATA
TGGAAGGACTAGAGGATTACTTTAGTGAAGATTCTTAGGCAGTTTTGTAACCCTTTTTCCTCAATAGCCTGTTTCCTGTTTTTAAGATTT
TGCCTTTGTTGTTGAAAAAGTGTTGCACTCTGTTGTGTAATTGTGACACAATTACAGCTGATTGCAGCCTCAACCTTCCCAGCTCAAGTG
ATCCTCCTACCTCAGCCTCCCAAGTAGTTGGGACCACAGGTGTGCACCCCATATCCAGCTATTTTTTTTCAATTTTTTTTGTAGAGGGGG
GGTCTCCCTATGTTGCCCAGGCAGATCTCAGACTGCTGGGCTCAAGCGATCCTCACACCTCAGCCTCCCAGAGTGCTGGGATTACAGTTG
TGAGCCACTGTGCCTGGCCTTTCTTTTTTTAACCTTTTTGTTTAACTTCTCTCTTCACTGCATCCCAATCCATCTACAGGCATGCACACT
TATTAGGAAAGCAGGTTTGAGGTAACGAGACTTTCACTATATTTTGCTTTGACAGAAGGAAAGAGGAAGAGTTTCTATTAAAATCTGTCA
CTTGAGTGATGTCATTCAAGTCCTATTTTAGGAGATAAAAACACCTTTGGGGACTGGTTAAAGTCCCCCAGAAACTACAATAAAGAACAA

>86151_86151_2_SPTBN2-PRIM2_SPTBN2_chr11_66472068_ENST00000529997_PRIM2_chr6_57467079_ENST00000607273_length(amino acids)=920AA_BP=892
MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRN
LLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKD
ALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSII
TYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFT
EKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ
DNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDL
LYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELA
AARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASA
RAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQA
AALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQSLIKVTLR

--------------------------------------------------------------
>86151_86151_3_SPTBN2-PRIM2_SPTBN2_chr11_66472069_ENST00000309996_PRIM2_chr6_57467080_ENST00000607273_length(transcript)=3933nt_BP=2750nt
CCACTGAGCAGCCAACCGCAGCCTCTGGCCACAAGGAGAGCGGAGCACAGGAGCAGGAAGCCGCCTACCACCATGAGCAGCACGCTGTCA
CCCACAGACTTTGACAGCTTGGAAATCCAGGGCCAGTACAGTGACATCAACAACCGCTGGGACCTTCCTGACTCGGACTGGGACAATGAC
AGCAGCTCGGCCCGCCTCTTTGAGAGGTCTCGCATTAAGGCTCTGGCAGATGAACGAGAAGCTGTGCAGAAGAAAACCTTCACCAAGTGG
GTAAACTCGCACCTGGCCCGGGTCACGTGCCGGGTGGGGGACCTGTACAGCGACCTCCGGGACGGACGCAACCTGCTGAGGCTCCTCGAG
GTGCTCTCGGGAGAGATACTGCCAAAGCCTACAAAGGGCCGCATGCGGATCCACTGCCTGGAGAACGTGGACAAGGCACTGCAGTTCCTC
AAGGAGCAGAAAGTGCACTTGGAAAACATGGGCTCCCATGACATTGTGGACGGAAACCACCGACTGACCCTTGGGCTGGTCTGGACCATC
ATCCTTCGATTCCAGATCCAAGACATCAGTGTGGAGACAGAAGACAACAAGGAGAAGAAGTCAGCCAAGGATGCCCTGCTTCTGTGGTGC
CAGATGAAGACTGCAGGTTATCCCAACGTCAATGTACACAACTTCACCACCAGCTGGAGAGATGGACTAGCTTTCAACGCCATCGTGCAT
AAACACCGGCCAGACCTGCTGGATTTTGAGTCTCTGAAGAAGTGTAATGCACACTATAATCTGCAGAATGCATTCAATCTGGCTGAAAAG
GAACTGGGACTTACCAAGCTGCTGGATCCCGAAGACGTGAATGTGGACCAGCCAGATGAGAAGTCAATCATTACCTATGTGGCTACTTAC
TACCATTACTTCTCCAAGATGAAGGCCCTGGCCGTGGAAGGCAAGAGAATTGGCAAGGTGCTGGACCATGCCATGGAGGCAGAGCGCCTG
GTGGAGAAATACGAGTCCCTGGCCTCGGAGCTGCTGCAGTGGATCGAGCAAACGATCGTGACCCTCAATGACCGGCAGTTGGCCAACTCC
CTTAGCGGGGTCCAGAACCAGCTGCAGTCCTTCAACTCCTACCGCACCGTGGAGAAGCCGCCCAAGTTTACCGAGAAAGGGAACTTGGAA
GTGCTGCTCTTCACCATCCAGAGCAAGCTTCGGGCCAACAACCAGAAGGTCTACACGCCCCGCGAGGGCCGGCTCATCTCGGACATCAAC
AAGGCTTGGGAGCGGCTGGAGAAGGCGGAGCACGAGCGTGAGCTGGCCCTGCGCACCGAGCTCATCCGCCAGGAGAAGCTGGAGCAGCTG
GCCGCCCGCTTCGACCGCAAGGCTGCCATGCGGGAGACCTGGCTCAGCGAGAACCAGCGCCTCGTGTCCCAGGACAACTTTGGGCTGGAG
CTGGCAGCTGTCGAGGCAGCAGTACGGAAGCACGAAGCCATTGAGACGGACATCGTGGCCTACAGCGGCCGGGTGCAGGCAGTGGACGCC
GTGGCTGCAGAGCTGGCCGCCGAGCGCTACCACGACATCAAGCGCATCGCCGCTCGGCAGCACAACGTGGCACGGCTCTGGGACTTCTTG
CGGCAGATGGTGGCCGCCCGGCGGGAGCGGCTCCTCCTCAACCTGGAGCTGCAGAAGGTGTTCCAGGACCTGCTCTACCTCATGGACTGG
ATGGAAGAGATGAAGGGCCGGCTGCAGTCTCAGGACCTGGGCAGGCACCTAGCAGGAGTGGAGGACCTGCTGCAGCTGCACGAGCTGGTG
GAGGCAGACATCGCCGTGCAGGCCGAGAGGGTGCGGGCCGTCAGCGCCTCTGCCCTGCGCTTCTGCAACCCAGGGAAAGAGTATAGACCT
TGCGACCCGCAGCTGGTGTCGGAGCGGGTGGCCAAGCTAGAGCAGAGCTATGAGGCACTGTGCGAGTTGGCAGCGGCGCGGCGGGCCCGG
CTGGAGGAATCACGGCGGCTCTGGCGTTTCCTCTGGGAGGTGGGTGAAGCTGAGGCCTGGGTGCGGGAGCAGCAGCACCTCCTGGCCTCA
GCCGACACGGGCCGAGACCTGACCGGTGCCCTCCGCCTGCTCAACAAGCACACAGCCCTGCGGGGCGAGATGAGCGGCCGGCTGGGGCCC
CTGAAGCTCACCCTGGAGCAGGGCCAGCAGTTGGTGGCCGAGGGTCACCCTGGGGCAAGCCAGGCCTCTGCCCGTGCAGCTGAACTCCAA
GCCCAGTGGGAGCGGCTAGAGGCCCTGGCCGAGGAGCGTGCCCAGCGGCTGGCCCAAGCCGCCAGCCTCTACCAGTTCCAGGCCGATGCA
AACGACATGGAGGCCTGGTTGGTTGACGCACTGCGCCTGGTGTCCAGCCCCGAGCTGGGGCACGACGAGTTCTCCACGCAGGCTCTAGCC
AGGCAGCATCGGGCCCTGGAGGAGGAGATTCGAAGCCACCGGCCAACCCTGGACGCCTTGAGGGAACAGGCAGCAGCCCTGCCCCCCACA
CTGAGCCGCACGCCCGAGGTGCAGAGCCGGGTGCCCACCCTGGAGCGGCACTACGAGGAGCTGCAGGCCCGGGCAGGCGAGCGAGCGCGG
GCCTTGGAGGCAGCCCTGGCGCTCTACACCATGCTCAGCGAGGCCGGGGCCTGTGGACTCTGGGTGGAGGAGAAGGAGCAGTGGCTCAAC
GGGCTGGCCCTGCCTGAACGCCTGGAGGACCTGGAGGTCGTGCAGCAGAGTTTGATAAAGGTTACTCTTAGAACATCCGTCACAGCTTTG
GAAAGGAAGGCAAGAGGACAGACTATACACCTTTCAGTTGCCTGAAGATTATTCTATCCAATCCACCAAGCCAAGGGGATTATCATGGGT
GCCCATTCCGTCACAGTGATCCAGAGCTGCTGAAGCAAAAGTTGCAGTCATACAAGATCTCTCCTGGAGGGATAAGCCAGATTTTGGATT
TAGTAAAGGGGACACATTACCAGGTAGCCTGTCAAAAATACTTTGAGATGATACACAATGTGGGTGATTGTGGCTTTTCTTTGAATCATC
CTAATCATTTCTTTTGTGAGAGCCAACGTATTCTAAATGGTGGTAAAGACATAAAGAAGGAATCTATCCAACCAGAAACTCCTCAACCCA
AACCAAGTGTCCAGAAAACCAAGGATGCATCATCTGCTCTGGCCTCTTTAAATTCCTCTCTGGAAATGGATATGGAAGGACTAGAGGATT
ACTTTAGTGAAGATTCTTAGGCAGTTTTGTAACCCTTTTTCCTCAATAGCCTGTTTCCTGTTTTTAAGATTTTGCCTTTGTTGTTGAAAA
AGTGTTGCACTCTGTTGTGTAATTGTGACACAATTACAGCTGATTGCAGCCTCAACCTTCCCAGCTCAAGTGATCCTCCTACCTCAGCCT
CCCAAGTAGTTGGGACCACAGGTGTGCACCCCATATCCAGCTATTTTTTTTCAATTTTTTTTGTAGAGGGGGGGTCTCCCTATGTTGCCC
AGGCAGATCTCAGACTGCTGGGCTCAAGCGATCCTCACACCTCAGCCTCCCAGAGTGCTGGGATTACAGTTGTGAGCCACTGTGCCTGGC
CTTTCTTTTTTTAACCTTTTTGTTTAACTTCTCTCTTCACTGCATCCCAATCCATCTACAGGCATGCACACTTATTAGGAAAGCAGGTTT
GAGGTAACGAGACTTTCACTATATTTTGCTTTGACAGAAGGAAAGAGGAAGAGTTTCTATTAAAATCTGTCACTTGAGTGATGTCATTCA
AGTCCTATTTTAGGAGATAAAAACACCTTTGGGGACTGGTTAAAGTCCCCCAGAAACTACAATAAAGAACAACTTTTGTTTTAACTCTTA

>86151_86151_3_SPTBN2-PRIM2_SPTBN2_chr11_66472069_ENST00000309996_PRIM2_chr6_57467080_ENST00000607273_length(amino acids)=943AA_BP=915
MSSQPQPLATRRAEHRSRKPPTTMSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWV
NSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTII
LRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKE
LGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSL
SGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLA
ARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLR
QMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPC
DPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPL
KLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALAR
QHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG

--------------------------------------------------------------
>86151_86151_4_SPTBN2-PRIM2_SPTBN2_chr11_66472069_ENST00000529997_PRIM2_chr6_57467080_ENST00000607273_length(transcript)=3861nt_BP=2678nt
ATGAGCAGCACGCTGTCACCCACAGACTTTGACAGCTTGGAAATCCAGGGCCAGTACAGTGACATCAACAACCGCTGGGACCTTCCTGAC
TCGGACTGGGACAATGACAGCAGCTCGGCCCGCCTCTTTGAGAGGTCTCGCATTAAGGCTCTGGCAGATGAACGAGAAGCTGTGCAGAAG
AAAACCTTCACCAAGTGGGTAAACTCGCACCTGGCCCGGGTCACGTGCCGGGTGGGGGACCTGTACAGCGACCTCCGGGACGGACGCAAC
CTGCTGAGGCTCCTCGAGGTGCTCTCGGGAGAGATACTGCCAAAGCCTACAAAGGGCCGCATGCGGATCCACTGCCTGGAGAACGTGGAC
AAGGCACTGCAGTTCCTCAAGGAGCAGAAAGTGCACTTGGAAAACATGGGCTCCCATGACATTGTGGACGGAAACCACCGACTGACCCTT
GGGCTGGTCTGGACCATCATCCTTCGATTCCAGATCCAAGACATCAGTGTGGAGACAGAAGACAACAAGGAGAAGAAGTCAGCCAAGGAT
GCCCTGCTTCTGTGGTGCCAGATGAAGACTGCAGGTTATCCCAACGTCAATGTACACAACTTCACCACCAGCTGGAGAGATGGACTAGCT
TTCAACGCCATCGTGCATAAACACCGGCCAGACCTGCTGGATTTTGAGTCTCTGAAGAAGTGTAATGCACACTATAATCTGCAGAATGCA
TTCAATCTGGCTGAAAAGGAACTGGGACTTACCAAGCTGCTGGATCCCGAAGACGTGAATGTGGACCAGCCAGATGAGAAGTCAATCATT
ACCTATGTGGCTACTTACTACCATTACTTCTCCAAGATGAAGGCCCTGGCCGTGGAAGGCAAGAGAATTGGCAAGGTGCTGGACCATGCC
ATGGAGGCAGAGCGCCTGGTGGAGAAATACGAGTCCCTGGCCTCGGAGCTGCTGCAGTGGATCGAGCAAACGATCGTGACCCTCAATGAC
CGGCAGTTGGCCAACTCCCTTAGCGGGGTCCAGAACCAGCTGCAGTCCTTCAACTCCTACCGCACCGTGGAGAAGCCGCCCAAGTTTACC
GAGAAAGGGAACTTGGAAGTGCTGCTCTTCACCATCCAGAGCAAGCTTCGGGCCAACAACCAGAAGGTCTACACGCCCCGCGAGGGCCGG
CTCATCTCGGACATCAACAAGGCTTGGGAGCGGCTGGAGAAGGCGGAGCACGAGCGTGAGCTGGCCCTGCGCACCGAGCTCATCCGCCAG
GAGAAGCTGGAGCAGCTGGCCGCCCGCTTCGACCGCAAGGCTGCCATGCGGGAGACCTGGCTCAGCGAGAACCAGCGCCTCGTGTCCCAG
GACAACTTTGGGCTGGAGCTGGCAGCTGTCGAGGCAGCAGTACGGAAGCACGAAGCCATTGAGACGGACATCGTGGCCTACAGCGGCCGG
GTGCAGGCAGTGGACGCCGTGGCTGCAGAGCTGGCCGCCGAGCGCTACCACGACATCAAGCGCATCGCCGCTCGGCAGCACAACGTGGCA
CGGCTCTGGGACTTCTTGCGGCAGATGGTGGCCGCCCGGCGGGAGCGGCTCCTCCTCAACCTGGAGCTGCAGAAGGTGTTCCAGGACCTG
CTCTACCTCATGGACTGGATGGAAGAGATGAAGGGCCGGCTGCAGTCTCAGGACCTGGGCAGGCACCTAGCAGGAGTGGAGGACCTGCTG
CAGCTGCACGAGCTGGTGGAGGCAGACATCGCCGTGCAGGCCGAGAGGGTGCGGGCCGTCAGCGCCTCTGCCCTGCGCTTCTGCAACCCA
GGGAAAGAGTATAGACCTTGCGACCCGCAGCTGGTGTCGGAGCGGGTGGCCAAGCTAGAGCAGAGCTATGAGGCACTGTGCGAGTTGGCA
GCGGCGCGGCGGGCCCGGCTGGAGGAATCACGGCGGCTCTGGCGTTTCCTCTGGGAGGTGGGTGAAGCTGAGGCCTGGGTGCGGGAGCAG
CAGCACCTCCTGGCCTCAGCCGACACGGGCCGAGACCTGACCGGTGCCCTCCGCCTGCTCAACAAGCACACAGCCCTGCGGGGCGAGATG
AGCGGCCGGCTGGGGCCCCTGAAGCTCACCCTGGAGCAGGGCCAGCAGTTGGTGGCCGAGGGTCACCCTGGGGCAAGCCAGGCCTCTGCC
CGTGCAGCTGAACTCCAAGCCCAGTGGGAGCGGCTAGAGGCCCTGGCCGAGGAGCGTGCCCAGCGGCTGGCCCAAGCCGCCAGCCTCTAC
CAGTTCCAGGCCGATGCAAACGACATGGAGGCCTGGTTGGTTGACGCACTGCGCCTGGTGTCCAGCCCCGAGCTGGGGCACGACGAGTTC
TCCACGCAGGCTCTAGCCAGGCAGCATCGGGCCCTGGAGGAGGAGATTCGAAGCCACCGGCCAACCCTGGACGCCTTGAGGGAACAGGCA
GCAGCCCTGCCCCCCACACTGAGCCGCACGCCCGAGGTGCAGAGCCGGGTGCCCACCCTGGAGCGGCACTACGAGGAGCTGCAGGCCCGG
GCAGGCGAGCGAGCGCGGGCCTTGGAGGCAGCCCTGGCGCTCTACACCATGCTCAGCGAGGCCGGGGCCTGTGGACTCTGGGTGGAGGAG
AAGGAGCAGTGGCTCAACGGGCTGGCCCTGCCTGAACGCCTGGAGGACCTGGAGGTCGTGCAGCAGAGTTTGATAAAGGTTACTCTTAGA
ACATCCGTCACAGCTTTGGAAAGGAAGGCAAGAGGACAGACTATACACCTTTCAGTTGCCTGAAGATTATTCTATCCAATCCACCAAGCC
AAGGGGATTATCATGGGTGCCCATTCCGTCACAGTGATCCAGAGCTGCTGAAGCAAAAGTTGCAGTCATACAAGATCTCTCCTGGAGGGA
TAAGCCAGATTTTGGATTTAGTAAAGGGGACACATTACCAGGTAGCCTGTCAAAAATACTTTGAGATGATACACAATGTGGGTGATTGTG
GCTTTTCTTTGAATCATCCTAATCATTTCTTTTGTGAGAGCCAACGTATTCTAAATGGTGGTAAAGACATAAAGAAGGAATCTATCCAAC
CAGAAACTCCTCAACCCAAACCAAGTGTCCAGAAAACCAAGGATGCATCATCTGCTCTGGCCTCTTTAAATTCCTCTCTGGAAATGGATA
TGGAAGGACTAGAGGATTACTTTAGTGAAGATTCTTAGGCAGTTTTGTAACCCTTTTTCCTCAATAGCCTGTTTCCTGTTTTTAAGATTT
TGCCTTTGTTGTTGAAAAAGTGTTGCACTCTGTTGTGTAATTGTGACACAATTACAGCTGATTGCAGCCTCAACCTTCCCAGCTCAAGTG
ATCCTCCTACCTCAGCCTCCCAAGTAGTTGGGACCACAGGTGTGCACCCCATATCCAGCTATTTTTTTTCAATTTTTTTTGTAGAGGGGG
GGTCTCCCTATGTTGCCCAGGCAGATCTCAGACTGCTGGGCTCAAGCGATCCTCACACCTCAGCCTCCCAGAGTGCTGGGATTACAGTTG
TGAGCCACTGTGCCTGGCCTTTCTTTTTTTAACCTTTTTGTTTAACTTCTCTCTTCACTGCATCCCAATCCATCTACAGGCATGCACACT
TATTAGGAAAGCAGGTTTGAGGTAACGAGACTTTCACTATATTTTGCTTTGACAGAAGGAAAGAGGAAGAGTTTCTATTAAAATCTGTCA
CTTGAGTGATGTCATTCAAGTCCTATTTTAGGAGATAAAAACACCTTTGGGGACTGGTTAAAGTCCCCCAGAAACTACAATAAAGAACAA

>86151_86151_4_SPTBN2-PRIM2_SPTBN2_chr11_66472069_ENST00000529997_PRIM2_chr6_57467080_ENST00000607273_length(amino acids)=920AA_BP=892
MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRN
LLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKD
ALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSII
TYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFT
EKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ
DNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDL
LYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELA
AARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASA
RAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQA
AALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQSLIKVTLR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPTBN2-PRIM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPTBN2-PRIM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPTBN2-PRIM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource